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Turmeric as antioxidant

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https://www.readbyqxmd.com/read/27928704/antioxidant-effects-of-curcuminoids-in-patients-with-type-2-diabetes-mellitus-a-randomized-controlled-trial
#1
Yunes Panahi, Nahid Khalili, Ebrahim Sahebi, Soha Namazi, Maryam Saberi Karimian, Muhammed Majeed, Amirhossein Sahebkar
BACKGROUND: Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals. METHODS: In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks...
December 7, 2016: Inflammopharmacology
https://www.readbyqxmd.com/read/27895783/curcumin-suppresses-colon-cancer-cell-invasion-via-ampk-induced-inhibition-of-nf-%C3%AE%C2%BAb-upa-activator-and-mmp9
#2
Weihua Tong, Quan Wang, Donghui Sun, Jian Suo
Curcumin, an active nontoxic ingredient of turmeric, possesses potent anti-inflammatory, antioxidant and anti-cancer properties; however, the molecular mechanisms of curcumin are not fully understood. The transcription factor nuclear factor-κB (NF-κB) is key in cellular processes, and the expression/activation of urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP9) are crucial for cell invasion. The present study investigated the hypothesis that curcumin inhibits colon cancer cell invasion by modulating NF-κB-mediated expression and activation of uPA and MMP9...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27863601/clinical-efficacy-of-turmeric-use-in-gingivitis-a-comprehensive-review
#3
REVIEW
Karissa A Stoyell, Jennifer L Mappus, Mona A Gandhi
INTRODUCTION: Gingivitis affects an estimated 80% of the population, and is characterized as the world's most predominant inflammatory periodontal disease. Without intervention, gingivitis can advance to alveolar bone loss. Therefore, the primary goal in patients suffering with gingivitis is to control plaque buildup and soft tissue inflammation. Current guidelines consider chlorhexidine as the gold standard in the prevention and treatment of gingivitis. However, negative side effects of chlorhexidine, including oral mucosal erosion, discoloration of teeth, and bitter taste, provide an opportunity for alternative medications...
November 2016: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/27807473/therapeutic-potential-of-curcumin-for-the-treatment-of-brain-tumors
#4
REVIEW
Neil V Klinger, Sandeep Mittal
Brain malignancies currently carry a poor prognosis despite the current multimodal standard of care that includes surgical resection and adjuvant chemotherapy and radiation. As new therapies are desperately needed, naturally occurring chemical compounds have been studied for their potential chemotherapeutic benefits and low toxicity profile. Curcumin, found in the rhizome of turmeric, has extensive therapeutic promise via its antioxidant, anti-inflammatory, and antiproliferative properties. Preclinical in vitro and in vivo data have shown it to be an effective treatment for brain tumors including glioblastoma multiforme...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27792130/vitamin-e-turmeric-and-saffron-in-treatment-of-alzheimer-s-disease
#5
REVIEW
Nur Adalier, Heath Parker
Alzheimer's disease (AD) is a growing epidemic and currently there is no cure for the disease. The disease has a detrimental effect on families and will strain the economy and health care systems of countries worldwide. The paper provides a literature review on a few ongoing possible antioxidant therapy treatments for the disease. The paper highlights use of vitamin E, turmeric and saffron for an alternative antioxidant therapy approach. Clinical studies report their therapeutic abilities as protective agents for nerve cells against free radical damage, moderating acetylcholinesterase (AChE) activity and reducing neurodegeneration, which are found as key factors in Alzheimer's...
October 25, 2016: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/27693453/development-of-a-neuroprotective-potential-algorithm-for-medicinal-plants
#6
Weixi Liu, Hang Ma, Nicholas A DaSilva, Kenneth N Rose, Shelby L Johnson, Lu Zhang, Chunpeng Wan, Joel A Dain, Navindra P Seeram
Medicinal plants are promising candidates for Alzheimer's disease (AD) research but there is lack of systematic algorithms and procedures to guide their selection and evaluation. Herein, we developed a Neuroprotective Potential Algorithm (NPA) by evaluating twenty-three standardized and chemically characterized Ayurvedic medicinal plant extracts in a panel of bioassays targeting oxidative stress, carbonyl stress, protein glycation, amyloid beta (Aβ) fibrillation, acetylcholinesterase (AChE) inhibition, and neuroinflammation...
September 29, 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27671811/berberine-and-its-role-in-chronic-disease
#7
Arrigo F G Cicero, Alessandra Baggioni
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis [e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric)], Hydrastis canadensis (goldenseal), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense ([2]) (Amur corktree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia, Argemone mexicana (prickly poppy) and Eschscholzia californica (Californian poppy). In vitro it exerts significant anti-inflammatory and antioxidant activities...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27671810/curcumin-and-its-role-in-chronic-diseases
#8
A Kunwar, K I Priyadarsini
Curcumin, a yellow pigment from the spice turmeric, is used in Indian and Chinese medicine since ancient times for wide range of diseases. Extensive scientific research on this molecule performed over the last 3 to 4 decades has proved its potential as an important pharmacological agent. The antioxidant, anti-inflammatory, antimicrobial and chemopreventive activities of curcumin have been extended to explore this molecule against many chronic diseases with promising results. Further, its multitargeting ability and nontoxic nature to humans even up to 12 g/day have attracted scientists to explore this as an anticancer agent in the clinic, which is in different phases of trials...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27664636/spices-in-the-management-of-diabetes-mellitus
#9
REVIEW
Xinyan Bi, Joseph Lim, Christiani Jeyakumar Henry
Diabetes mellitus (DM) remains a major health care problem worldwide both in developing and developed countries. Many factors, including age, obesity, sex, and diet, are involved in the etiology of DM. Nowadays, drug and dietetic therapies are the two major approaches used for prevention and control of DM. Compared to drug therapy, a resurgence of interest in using diet to manage and treat DM has emerged in recent years. Conventional dietary methods to treat DM include the use of culinary herbs and/or spices...
February 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27640646/wound-healing-effects-of-curcumin-a-short-review
#10
REVIEW
Silvia Tejada, Azadeh Manayi, Maria Daglia, Seyed F Nabavi, Antoni Sureda, Zohreh Hajheydari, Olga Gortzi, Hamidreza Pazoki-Toroudi, Seyed M Nabavi
Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment...
2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27623179/curcumin-modulates-oxidative-stress-and-genotoxicity-induced-by-a-type-ii-fluorinated-pyrethroid-beta-cyfluthrin
#11
Rajbala Verma, Kumud Kant Awasthi, Neelu Kanwar Rajawat, Inderpal Soni, P J John
Present study examines the possibility of β-cyfluthrin (β-CYF) induced oxidative stress, genotoxicity, histopathological alterations and the role of curcumin (CUR) in alleviating its toxic effects. CUR is a naturally occurring phenolic compound of turmeric (Curcuma longa) and is used as a spice, food-coloring agent and in cosmetics and medicines. CUR provides vital protection against many pathological conditions due to its antioxidant and anti-inflammatory properties. Male Swiss albino mice were distributed into six groups, I: control, II: CUR (0...
September 10, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27619637/neuroprotective-effect-of-curcumin-as-evinced-by-abrogation-of-rotenone-induced-motor-deficits-oxidative-and-mitochondrial-dysfunctions-in-mouse-model-of-parkinson-s-disease
#12
Dharmendra K Khatri, Archana R Juvekar
Curcumin, a natural polyphenolic compound extracted from rhizomes of Curcuma longa (turmeric), a plant in the ginger family (Zingiberaceae) has been used worldwide and extensively in Southeast Asia. Curcumin exhibited numerous biological and pharmacological activities including potent antioxidant, cardiovascular disease, anticancer, anti-inflammatory effects and neurodegenerative disorders in cell cultures and animal models. Hence, the present study was designed in order to explore the possible neuroprotective role of curcumin against rotenone induced cognitive impairment, oxidative and mitochondrial dysfunction in mice...
September 9, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27572503/curcumin-inhibits-h2o2-induced-invasion-and-migration-of-human-pancreatic-cancer-via-suppression-of-the-erk-nf-%C3%AE%C2%BAb-pathway
#13
Lei Cao, Jiangbo Liu, Lun Zhang, Xue Xiao, Wei Li
Curcumin (diferuloylmethane), a natural polyphenol present in turmeric, possesses a wide spectrum of pharmacological properties, including antioxidant and antitumor metastatic activities. However, the underlying mechanisms by which curcumin suppresses the metastasis of pancreatic cancer are still not fully elucidated. Our previous study demonstrated that a moderate amount of hydrogen peroxide (H2O2) is able to promote pancreatic cancer invasion. The aim of this study was to determine whether curcumin can suppress H2O2-induced tumor invasive and migratory abilities...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27482284/investigating-the-therapeutic-role-and-molecular-biology-of-curcumin-as-a-treatment-for-glioblastoma
#14
Gregor A Rodriguez, Ashish H Shah, Zachary C Gersey, Sumedh S Shah, Amade Bregy, Ricardo J Komotar, Regina M Graham
OBJECTIVES: Despite the aggressive standard of care for patients with glioblastoma multiforme, survival rates typically do not exceed 2 years. Therefore, current research is focusing on discovering new therapeutics or rediscovering older medications that may increase the overall survival of patients with glioblastoma. Curcumin, a component of the Indian natural spice, turmeric, also known for its antioxidant and anti-inflammatory properties, has been found to be an effective inhibitor of proliferation and inducer of apoptosis in many cancers...
July 2016: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/27448550/wound-healing-effects-of-curcumin-a-short-review
#15
Silvia Tejada, Azadeh Manayi, Maria Daglia, Seyed Fazel Nabavi, Antoni Sureda, Zohreh Hajheydari, Olga Gortzi, Hamidreza Pazoki-Toroudi, Seyed Mohammad Nabavi
Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment...
July 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27439410/wound-healing-effect-of-curcumin-a-review
#16
Silvia Tejada, Azadeh Manayi, Maria Daglia, Seyed Fazel Nabavi, Antoni Sureda, Zohreh Hajheydari, Olga Gortzi, Hamidreza Pazoki-Toroudi, Seyed Mohammad Nabavi
Wound healing is a complex process that consists of several phases that range from coagulation, inflammation, accumulation of radical substances, to proliferation, formation of fibrous tissues and collagen, contraction of wound with formation of granulation tissue and scar. Since antiquity, vegetable substances have been used as phytotherapeutic agents for wound healing, and more recently natural substances of vegetable origin have been studied with the attempt to show their beneficial effect on wound treatment...
July 21, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27416804/evaluation-of-ubtan-a-traditional-indian-skin-care-formulation
#17
Rajarshi Biswas, Pulok K Mukherjee, Amit Kar, Shiv Bahadur, Ranjit K Harwansh, Sayan Biswas, Naif Abdullah Al-Dhabi, V Duraipandiyan
ETHNOPHARMACOLOGICAL RELEVANCE: 'Ubtan' is a traditional herbal formulation in the Indian system of medicine being used in India and its subcontinent for a long time. Several commercial skin care formulations are marketed throughout this region as the name of Ubtan. Therefore, it is worthwhile to evaluate Ubtan in respect of its efficacy as skin care formulation. AIM OF THE STUDY: The present study was designed for the preparation of Ubtan and standardization through the chromatographic techniques by using suitable phyto-markers...
July 11, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27393429/screening-for-antibiofilm-and-antioxidant-potential-of-turmeric-curcuma-longa-extracts
#18
Sumreen Hayat, Anjum Nasim Sabri
The antibiofilm and antioxidant activities associated with turmeric were the main focus of the study. Antibacterial activity was explored against bacteria isolated from dental plaques and dental unit water lines exhibiting resistance against antibiotics and biocides respectively. This study provides a comparison of the natural plant extract against synthetic mouthwash, chemicals and commonly prescribed antibiotics. Methanol extract was more effective as compared to other extracts. Minimum inhibitory concentrations (MIC) ranged from 2...
July 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27383838/evidence-for-the-participation-of-acid-sensing-ion-channels-asics-in-the-antinociceptive-effect-of-curcumin-in-a-formalin-induced-orofacial-inflammatory-model
#19
Yongfu Wu, Dongyun Qin, Huiling Yang, Hui Fu
Curcumin, a major bioactive component of turmeric, has diverse therapeutic effects such as anti-inflammatory, antioxidant, anticancer, and antinociceptive activities. The acid-sensing ion channels (ASICs), which can be activated by acute drops in the extracellular pH, play an important role in nociception. However, very little is known about the interaction between ASICs and curcumin in nociception of inflammation. In our study, we investigated whether the antinociceptive effects of curcumin are mediated via ASICs using an orofacial nociceptive model and in vitro western blotting, immunofluorescence, whole-cell patch-clamp recordings in the trigeminal system...
July 6, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27325504/curcumin-and-insulin-resistance-molecular-targets-and-clinical-evidences
#20
Angélica Saraí Jiménez-Osorio, Adriana Monroy, Silvestre Alavez
Curcumin ((1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the main component of the Indian spice turmeric, has been used in traditional medicine to improve diabetes and its comorbidities. Since the last two decades, scientific research has shown that in addition to its antioxidant properties, curcumin could also work as protein homeostasis regulator and it is able to modulate other intracellular pathways. Curcumin supplementation has been proposed to improve insulin resistance (IR) through the activation of the insulin receptor and its downstream pathways in several experimental models, pointing out that its clinical use may be a good and innocuous strategy to improve IR-related diseases...
June 21, 2016: BioFactors
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