keyword
https://read.qxmd.com/read/38518404/medical-properties-market-potential-and-microbial-production-of-golden-polyketide-curcumin-for-food-biomedical-and-cosmetic-applications
#1
REVIEW
Selma Beganovic, Christoph Wittmann
Curcumin, a potent plant polyketide in turmeric, has gained recognition for its outstanding health benefits, including anti-inflammatory, antioxidant, and anticancer effects. Classical turmeric farming, which is widely used to produce curcumin, is linked to deforestation, soil degradation, excessive water use, and reduced biodiversity. In recent years, the microbial synthesis of curcumin has been achieved and optimized through novel strategies, offering increased safety, improved sustainability, and the potential to revolutionize production...
March 21, 2024: Current Opinion in Biotechnology
https://read.qxmd.com/read/38473770/how-does-radiation-affect-curcumin-raw-material
#2
JOURNAL ARTICLE
Natalia Rosiak, Ewa Garbiec, Waldemar Bednarski, Robert Skibiński, Kornelia Lewandowska, Aleksandra Bazan-Woźniak, Robert Pietrzak, Judyta Cielecka-Piontek, Przemysław Zalewski
Turmeric, known for its curcuminoid-rich rhizome, particularly curcumin, exhibits notable antioxidant and antiviral properties. The likelihood of microbial contamination necessitates finding reliable techniques for subjecting the sample to radiation from this plant-based raw material. One alternative is to expose curcumin to radiation (e-beam), which was carried out as part of this research. Confirmation of the lack of curcumin decomposition was carried out using HPLC-DAD/MS techniques. Additionally, using the EPR technique, the generated free radicals were defined as radiation effects...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38454972/phenotypical-and-molecular-assessments-on-the-pharmacological-effects-of-curcumin-in-drosophila-melanogaster
#3
JOURNAL ARTICLE
Nur R Rumata, Dewi Purwaningsih, Asbah Asbah, Muh Fadhil As'ad, Deepak Chadran, Talha B Emran, Firzan Nainu
Curcumin, a dietary polyphenol derived from turmeric's rhizome, exhibits a range of pharmacological activities, such as antioxidant, analgesic, antipyretic, and anti-inflammatory effects. It has been investigated for its therapeutic potential in chronic obstructive pulmonary disease (COPD) due to its ability to inhibit nuclear factor kappa B (NF-κB), modulate oxidative stress, impact cell viability, and regulate gene expression. However, most studies have been limited to in vitro conditions. To address this gap, we conducted in vivo experiments using the fruit fly Drosophila melanogaster to explore the antioxidant activities and biological significance of curcumin...
August 2023: Narra J
https://read.qxmd.com/read/38435752/development-of-curcumin-and-turmerone-loaded-solid-lipid-nanoparticle-for-topical-delivery-optimization-characterization-and-skin-irritation-evaluation-with-3d-tissue-model
#4
JOURNAL ARTICLE
Beyza Sümeyye Aydin, Ali Asram Sagiroglu, Dilek Ozturk Civelek, Mustafa Gokce, Fatemeh Bahadori
BACKGROUND: Curcuma longa L., commonly known as turmeric, is renowned for its therapeutic benefits attributed to bioactive compounds, namely curcumin (Cur) and aromatic turmerone (Tur), present in its rhizome. These compounds exhibit diverse therapeutic properties, including anti-inflammatory, antioxidant, and anti-tumor effects. However, the topical application of these compounds has a significant potential for inducing skin irritation. This study focuses on formulating solid lipid nanoparticle (SLN) carriers encapsulating both Cur and Tur for reduced irritation and enhanced stability...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38414990/turmeric-extract-mediated-biogenic-synthesis-of-ag-seo-2-magnetic-nanoparticles-characterization-optimization-antibacterial-and-antioxidant-activities
#5
JOURNAL ARTICLE
Abeer A Ghoniem, Khaled M Elattar, Fatimah O Al-Otibi, Ashraf Elsayed, Mohammed S El-Hersh, Ayman Y El-Khateeb, Yosra A Helmy, WesamEldin I A Saber
This study bio-synthesized Ag@SeO2 bmNPs successfully, using turmeric ethanol extract, and characterized them using various techniques. The FT-IR analysis reveals the involvement of these plant-derived compounds, especially phenolics, in the reduction process by acting as electron donors and stabilizing/capping agents. Zeta potential analysis showed a slight negative surface charge for the stability of Ag@SeO2 NPs, where TEM revealed spherical nanoparticles with an average size of 20 nm. The XRD confirmed crystallinity and a core-shell structure, and EDX identified elements consistent with Ag@SeO2 and a 3 : 1 Ag/Se atomic ratio...
February 21, 2024: RSC Advances
https://read.qxmd.com/read/38400893/curcumin-attenuates-aflatoxin-b1-induced-ileum-injury-in-ducks-by-inhibiting-nlrp3-inflammasome-and-regulating-tlr4-nf-%C3%AE%C2%BAb-signaling-pathway
#6
JOURNAL ARTICLE
Hang Pan, Ting Hu, Ying He, Gaolong Zhong, Shaofeng Wu, Xuanxuan Jiang, Gan Rao, Yanli You, Zhiyan Ruan, Zhaoxin Tang, Lianmei Hu
Aflatoxin B1 (AFB1) is a widespread toxic contamination in feed for animals. The primary active component of turmeric, curcumin (Cur), is an antioxidant and an anti-inflammatory. However, it is yet unknown how AFB1 affects the intestinal epithelial barrier and whether Cur acts as a protective mechanism when exposed to AFB1. Here, we explored the mechanism of AFB1-induced intestinal injury from intestinal epithelial barrier, inflammation, pyroptosis, and intestinal flora, and evaluated the protective role of Cur...
February 24, 2024: Mycotoxin Research
https://read.qxmd.com/read/38399221/the-fabrication-of-polymer-based-curcumin-loaded-formulation-as-a-drug-delivery-system-an-updated-review-from-2017-to-the-present
#7
REVIEW
Abul Kalam Azad, Joanne Lai, Wan Mohd Azizi Wan Sulaiman, Hassan Almoustafa, Salah Abdalrazak Alshehade, Vinoth Kumarasamy, Vetriselvan Subramaniyan
Turmeric contains curcumin, a naturally occurring compound with noted anti-inflammatory and antioxidant properties that may help fight cancer. Curcumin is readily available, nontoxic, and inexpensive. At high doses, it has minimal side effects, suggesting it is safe for human use. However, curcumin has extremely poor bioavailability and biodistribution, which further hamper its clinical applications. It is commonly administered through oral and transdermal routes in different forms, where the particle size is one of the most common barriers that decreases its absorption through biological membranes on the targeted sites and limits its clinical effectiveness...
January 24, 2024: Pharmaceutics
https://read.qxmd.com/read/38396341/the-ameliorative-effect-of-turmeric-curcuma-longa-linn-extract-and-its-major-constituent-curcumin-and-its-analogs-on-ethanol-toxicity
#8
REVIEW
Mahboobeh Ghasemzadeh Rahbardar, Hossein Hosseinzadeh
Ethanol toxicity is a major public health problem that can cause damage to various organs in the body by several mechanisms inducing oxidative stress, inflammation, and apoptosis. Recently, there has been a growing interest in the potential of herbal medicines as therapeutic agents for the prevention and treatment of various disorders. Turmeric (Curcuma longa) extracts and its main components including curcumin have antioxidant, anti-inflammatory, and anti-apoptotic properties. This review aims to evaluate the literature on the ameliorative effects of turmeric extracts and their main components on ethanol toxicity...
February 23, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38337251/electrochemical-analysis-of-curcumin-in-real-samples-using-intelligent-materials
#9
JOURNAL ARTICLE
Eduardo Jara-Cornejo, Erick Peña-Bedón, Mahely Torres Moya, Sergio Espinoza-Torres, Maria D P T Sotomayor, Gino Picasso, Juan C Tuesta, Rosario López, Sabir Khan
Curcumin is a compound of great importance in the food industry due to its biological and pharmacological properties, which include being an antioxidant, anti-inflammatory, antibacterial, antiviral, and anticarcinogenic. This paper proposes the synthesis of an electrochemical sensor based on molecularly imprinted polymers (MIPs) and MWCNT by drop casting deposited on a glassy carbon electrode (GCE) for the selective quantification of curcumin in food samples. The synthesized compounds are characterized by Fourier transform infrared (IR), Brunauer-Emmett-Teller (BET), and electrochemical techniques such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV)...
January 29, 2024: Polymers
https://read.qxmd.com/read/38298864/-curcuma-xanthorrhiza-extract-and-xanthorrhizol-ameliorate-cancer-induced-adipose-wasting-in-ct26-bearing-mice-by-regulating-lipid-metabolism-and-adipose-tissue-browning
#10
JOURNAL ARTICLE
Haeun Kim, Dong-Woo Lee, Jae-Kwan Hwang
BACKGROUND: Cancer cachexia-characterized by anorexia, body weight loss, skeletal muscle atrophy, and fat loss-affects nearly 80% of cancer patients and accounts for 20% of cancer deaths. Curcuma xanthorrhiza , known as Java turmeric, and its active compound xanthorrhizol (XAN) exhibit anticancer, anti-inflammatory, and antioxidant properties. However, the ameliorative effects of C. xanthorrhiza extract (CXE) and XAN on cancer-associated adipose atrophy remain unexplored. This study aimed to evaluate the therapeutic effects of CXE and XAN on cancer cachexia-induced adipose tissue wasting in CT26 tumor-bearing mice...
March 2024: Integrative Medicine Research
https://read.qxmd.com/read/38290997/phytotherapy-in-periodontics-as-an-effective-and-sustainable-supplemental-treatment-a-narrative-review
#11
REVIEW
Abeer Saad Gawish, Mohammed Sherif ElMofty, Safa Jambi, Doaa Felemban, Yassmeen SalahEldin Ragheb, Shadia Abdelhameed Elsayed
PURPOSE: Periodontal disease is a chronic condition caused by microbial infection and mediated by the host's immune response. Phytotherapy is a therapeutic approach that utilizes a renewable resource capable of supplying less expensive medicines for the world's growing population. This review aimed to present clinical evidence on the use of complementary medicinal herbs in the treatment of periodontal diseases. METHODS: Different databases were searched using the terms "herbal" and "periodontitis...
December 11, 2023: Journal of Periodontal & Implant Science
https://read.qxmd.com/read/38272248/mitigation-of-lens-opacification-by-a-functional-food-in-a-diabetic-rodent-model
#12
JOURNAL ARTICLE
Krishna K Kalahasti, Ch Uday Kumar, Marka Nagaraju, J Mark Petrash, S Sreenivasa Reddy, G Bhanuprakash Reddy
The current study was designed to test a functional food (FF) mixture containing aldose reductase inhibitors and anti-glycation bioactive compounds for suppressing the onset and progression of cataracts in a diabetic rat model. Two-month-old Sprague Dawley rats were grouped as control (C), diabetes untreated (D), and diabetic rats treated with FF at two doses (FF1 = 1.35 g and FF2 = 6.25 g/100g of diet). Diabetes was induced by a single injection of streptozotocin. The FF is a mixture of amla, turmeric, black pepper, cinnamon, ginger, and fenugreek added to the rodent diet...
January 23, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38232906/curcumin-effects-on-glycaemic-indices-lipid-profile-blood-pressure-inflammatory-markers-and-anthropometric-measurements-of-non-alcoholic-fatty-liver-disease-patients-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#13
REVIEW
Armin Ebrahimzadeh, Shokouh Mohseni, Mohammad Safargar, Abbas Mohtashamian, Sara Niknam, Mohammadreza Bakhoda, Sanaz Afshari, Amirhossein Jafari, Anahita Ebrahimzadeh, Sara Fooladshekan, Alireza Mohtashami, Gordon A Ferns, Siavash Babajafari, Zahra Sohrabi
OBJECTIVES: Curcumin has antioxidant properties and has been proposed as a potential treatment for NAFLD. The aim of current systematic review and meta-analysis was to evaluate previous findings for the effect of curcumin supplementation on glycaemic indices, lipid profile, blood pressure, inflammatory markers, and anthropometric measurements of NAFLD patients. METHODS: Relevant studies published up to January 2024 were searched systematically using the following databases: PubMed, SCOPUS, WOS, Science Direct, Ovid and Cochrane...
January 15, 2024: Complementary Therapies in Medicine
https://read.qxmd.com/read/38213574/curcumin-loaded-nanostructured-systems-for-treatment-of-leishmaniasis-a-review
#14
REVIEW
Douglas Dourado, Thayse Silva Medeiros, Éverton do Nascimento Alencar, Edijane Matos Sales, Fábio Rocha Formiga
Leishmaniasis is a neglected tropical disease that has affected more than 350 million people worldwide and can manifest itself in three different forms: cutaneous, mucocutaneous, or visceral. Furthermore, the current treatment options have drawbacks which compromise efficacy and patient compliance. To face this global health concern, new alternatives for the treatment of leishmaniasis have been explored. Curcumin, a polyphenol obtained from the rhizome of turmeric, exhibits leishmanicidal activity against different species of Leishmania spp ...
2024: Beilstein Journal of Nanotechnology
https://read.qxmd.com/read/38202711/therapeutic-potential-of-curcumin-a-bioactive-compound-of-turmeric-in-prevention-of-streptozotocin-induced-diabetes-through-the-modulation-of-oxidative-stress-and-inflammation
#15
JOURNAL ARTICLE
Abdullah Khalid Alsulaim, Turki Hussain Almutaz, Abdulaziz Ahmed Albati, Arshad Husain Rahmani
This study evaluates the anti-diabetic potential and underlying mechanisms of curcumin in streptozotocin (STZ)-induced type 2 diabetes mellitus (T2DM) rats. The rats were randomly divided into four groups: normal control, negative control (diabetic group), diabetic group receiving glibenclamide (positive control group), and curcumin plus STZ (treatment group). The anti-diabetic activities of curcumin were examined at a dose of 50 mg/kg body weight through physiological, biochemical, and histopathological analysis...
December 25, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38201943/oxidative-stress-and-natural-products-in-orthodontic-treatment-a-systematic-review
#16
REVIEW
Francesco Inchingolo, Angelo Michele Inchingolo, Giulia Latini, Laura Ferrante, Irma Trilli, Gaetano Del Vecchio, Giulia Palmieri, Giuseppina Malcangi, Alessio Danilo Inchingolo, Gianna Dipalma
In recent years, orthodontics, a specialized branch of dentistry, has evolved considerably in terms of both techniques and materials used. Aimed at correcting dental malocclusions and craniofacial anomalies, it improves the functionality and aesthetics of the face and oral cavity. However, orthodontic treatment, in its developmental stages, may induce oxidative stress (O.S.) phenomena, with an increase in the production of reactive oxygen species (ROS), damaging the dental and periodontal tissues involved, affecting the short-, medium- and long-term results...
December 28, 2023: Nutrients
https://read.qxmd.com/read/38192657/antioxidant-curcumin-induces-oxidative-stress-to-kill-tumor-cells-review
#17
REVIEW
Ye Hu, Lei Cheng, Shuguang Du, Kesi Wang, Shuangping Liu
Curcumin is a plant polyphenol in turmeric root and a potent antioxidant. It binds to antioxidant response elements for gene regulation by nuclear factor erythroid 2-related factor 2, thereby suppressing reactive oxygen species (ROS) and exerting anti-inflammatory, anti-infective and other pharmacological effects. Of note, curcumin induces oxidative stress in tumors. It binds to several enzymes in tumors, such as carbonyl reductases, glutathione S-transferase P1 and nicotinamide adenine dinucleotide phosphate to induce mitochondrial damage, increase ROS production and ultimately induce tumor cell death...
February 2024: Oncology Letters
https://read.qxmd.com/read/38183601/curcumin-and-ferroptosis-a-promising-target-for-disease-prevention-and-treatment
#18
REVIEW
Zahra Foroutan, Alexandra E Butler, Gokhan Zengin, Amirhossein Sahebkar
Ferroptosis is a recently identified form of cell death characterized by iron accumulation and lipid peroxidation. Unlike apoptosis, necrosis, and autophagy, ferroptosis operates through a distinct molecular pathway. Curcumin, derived from turmeric rhizomes, is a natural compound with diverse therapeutic benefits, including neuroprotective, anti-metabolic syndrome, anti-inflammatory, and anti-cancer properties. Growing evidence suggests that curcumin possesses both pro-oxidant and antioxidant properties, which can vary depending on the cell type...
January 6, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38141737/promotion-of-transcription-factor-eb-dependent-autophagic-process-by-curcumin-alleviates-arsenic-caused-lung-oxidative-stress-and-inflammation-in-mice
#19
JOURNAL ARTICLE
Guowei Xu, Haiyang Chen, Zheng Cong, Ruiqiang Wang, Xiangping Li, Yuxuan Xie, Yi Wang, Bing Li
Arsenic is a human carcinogen widely distributed in the environment, and arsenic exposure from drinking water has received widespread attention as a global public health problem. Curcumin is a natural bioactive substance with high efficiency and low toxicity extracted from turmeric, which has a variety of biological properties such as anti-oxidation, anti-inflammation, anti-cancer, and immuno-modulatory activities. Curcumin is widely used in daily life as a food additive and dietary supplement. However, its protective effects in lung injuries by chronic arsenic exposure orally remain unexplored...
December 21, 2023: Journal of Nutritional Biochemistry
https://read.qxmd.com/read/38141282/targeted-therapies-of-curcumin-focus-on-its-therapeutic-benefits-in-cancers-and-human-health-molecular-signaling-pathway-based-approaches-and-future-perspectives
#20
REVIEW
Md Rezaul Islam, Abdur Rauf, Shopnil Akash, Sadiya Islam Trisha, Akram Hossain Nasim, Muniya Akter, Puja Sutro Dhar, Hanan A Ogaly, Hassan A Hemeg, Polrat Wilairatana, Muthu Thiruvengadam
The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orange-yellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement...
December 22, 2023: Biomedicine & Pharmacotherapy
keyword
keyword
119207
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.