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Selenium role as antioxidant

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https://www.readbyqxmd.com/read/27921246/investigation-of-selenium-pretreatment-in-the-attenuation-of-lung-injury-in-rats-induced-by-fine-particulate-matters
#1
Jie Liu, Yingying Yang, Xuejiao Zeng, Liang Bo, Shuo Jiang, Xihao Du, Yuquan Xie, Rongfang Jiang, Jinzhuo Zhao, Weimin Song
Selenium (Se) is vital for health because of its antioxidative and anti-inflammation functions. The aim of this study was to determine if dietary selenium could inhibit the rat lung injury induced by ambient fine particulate matter (PM2.5). Sprague-Dawley rats were randomly allocated in seven groups (n = 8). The rats in PM2.5 exposure group were intratracheally instilled with 40 mg/kg of body weight (b.w.) of PM2.5 suspension. The rats in Se prevention groups were pretreated with 17.5, 35, or 70 μg/kg b...
December 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27914996/long-term-organic-selenium-supplementation-overcomes-the-trade-off-between-immune-and-antioxidant-systems-in-pacu-piaractus-mesopotamicus
#2
Leonardo Susumu Takahashi, Jaqueline Dalbello Biller-Takahashi, Cleber Fernando Menegasso Mansano, Elisabeth Criscuolo Urbinati, Rodrigo Yukihiro Gimbo, Marcos Vinícius Saita
Selenium (Se) is an essential nutrient for antioxidant defenses in fish because of its role in preventing immunosuppression caused by oxidative stress. In this study it was demonstrated the relation between the oxidative stress and immune status after a long Se supplementation period, as a result of the evaluation of immunological, hematological and antioxidant responses, as well as growth performance of pacu fed diets supplemented with different concentrations of organic selenium (0, 0.3, 0.6, 0.9, and 1.8 mg Se-yeast/kg, but the final analyzed selenium concentrations were 0...
November 30, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27908410/elevated-serum-mda-and-depleted-non-enzymatic-antioxidants-macro-minerals-and-trace-elements-are-associated-with-bipolar-disorder
#3
Manjurul Islam Chowdhury, Maimuna Hasan, Mohammad Safiqul Islam, Md Shahid Sarwar, Mohammad Nurul Amin, S M Naim Uddin, Md Zahedur Rahaman, Sujan Banik, Md Saddam Hussain, Kazushige Yokota, Abul Hasnat
Genetic and neurobiological factors are considered to be the major causes of mood and mental disorders. However, over the past few years, increased levels of serum malondialdehyde and altered levels of various non-enzymatic antioxidants and essential minerals involved in abnormal functional activity have been identified as major contributing factors to the pathogenesis of several neurological disorders. The aim of this study was to determine the levels of the serum lipid peroxidation product malondialdehyde (MDA), antioxidants (vitamin A, E and C), macro-minerals (calcium, potassium and sodium) and trace elements (zinc, iron and selenium) in patients with bipolar disorder and to explore their role in disease progression...
January 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27866465/polyphenol-rich-foods-alleviate-pain-and-ameliorate-quality-of-life-in-fibromyalgic-women
#4
Renata Costa de Miranda, Eduardo S Paiva, Silvia Maria Suter Correia Cadena, Anna Paula Brandt, Regina Maria Vilela
OBJECTIVES: The present study aimed to describe the antioxidant dietary intake of patients with fibromyalgia and explore the association of the results with glutathione status, pain, quality of life, and socioeconomic status. METHODS: 38 fibromyalgic female patients and 35 female controls (mean age = 48.6 ± 8.1 and 47.6 ± 10.0 years, respectively) were evaluated. The number of tender points, pain threshold, quality of life, physical activity, socioeconomic status, nutritional status, intake of antioxidant micronutrients and foods with high total antioxidant capacity, and total salivary glutathione were evaluated...
November 21, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27856111/sensitization-of-cancer-cells-to-cyclophosphamide-therapy-by-an-organoselenium-compound-through-ros-mediated-apoptosis
#5
Pramita Chakraborty, Somnath Singha Roy, Abhishek Basu, Sudin Bhattacharya
Induction of apoptosis has been recognized as an excellent therapeutic approach in cancer. Selenium based compounds are well known for their antitumor and synergistic chemotherapeutic efficacy when combined with a standard antineoplastic drug. Previously, we have reported that an organoselenium compound, diphenylmethyl selenocyanate (DMSE) could effectively protect normal organs and tissues from the toxicity induced by a standard chemotherapeutic drug cyclophosphamide in a tumor bearing mouse model. In this study, as a further step, we have evaluated the effect of DMSE in sensitization of tumor cells to cyclophosphamide-induced cell death...
November 14, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27818732/evaluation-of-some-biochemical-parameters-and-brain-oxidative-stress-in-experimental-rats-exposed-chronically-to-silver-nitrate-and-the-protective-role-of-vitamin-e-and-selenium
#6
Mouna Gueroui, Zine Kechrid
Due to undesirable hazardous interactions with biological systems, this investigation was undertaken to evaluate the effect of chronic exposure to silver on certain biochemical and some oxidative stress parameters with histopathological examination of brain, as well as the possible protective role of selenium and/or vitamin E as nutritional supplements. Thirty six male rats were divided into six groups of six each: the first group used as a control group. Group II given both vitamin E (400 mg/kg) of diet and selenium (Se) (1 mg/L) in their drinking water...
October 2016: Toxicological Research
https://www.readbyqxmd.com/read/27730079/oxidative-stress-in-hypothyroid-patients-and-the-role-of-antioxidant-supplementation
#7
Sumit Kumar Chakrabarti, Sujoy Ghosh, Sandip Banerjee, Satinath Mukherjee, Subhankar Chowdhury
CONTEXT: The available data concerning oxidant stress and antioxidant capacity in hypothyroidism are scanty and inconclusive. While some authors suggest that tissues may be protected from oxidant damage because of a hypometabolic state in hypothyroidism, others report increased oxidative stress in hypothyroidism. Selenium acts as a cofactor for the thyroid hormone (TH) deiodinases that activate and then deactivate various THs and their metabolites. Selenium may inhibit thyroid autoimmunity...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27696310/chemoprotective-and-chemosensitizing-properties-of-selenium-nanoparticle-nano-se-during-adjuvant-therapy-with-cyclophosphamide-in-tumor-bearing-mice
#8
Arin Bhattacharjee, Abhishek Basu, Jaydip Biswas, Tuhinadri Sen, Sudin Bhattacharya
Cyclophosphamide (CP) is one of the widely used anticancer agents; however, it has serious deleterious effects on normal host cells due to its nonspecific action. The essential trace element Selenium (Se) is suggested to have chemopreventive and chemotherapeutic efficacy and currently used in pharmaceutical formulations. Previous report had shown Nano-Se could protect CP-induced hepatotoxicity and genotoxicity in normal Swiss albino mice; however, its role in cancer management is still not clear. The aim of present study is to investigate the chemoprotective efficacy of Nano-Se against CP-induced toxicity as well as its chemoenhancing capability when used along with CP in Swiss albino mice against Ehrlich's ascites carcinoma (EAC) cells...
October 1, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27620958/protective-role-of-selenium-in-the-activities-of-antioxidant-enzymes-in-piglet-splenic-lymphocytes-exposed-to-deoxynivalenol
#9
Xuemei Wang, Zhicai Zuo, Chuanping Zhao, Zhuo Zhang, Guangneng Peng, Suizhong Cao, Yanchun Hu, Shumin Yu, Zhijun Zhong, Junliang Deng, Zhihua Ren
We evaluated the effects of selenium (Se) on antioxidant enzymes of piglet splenic lymphocytes exposed to deoxynivalenol (DON). We measured cell viability, the activities of several antioxidant enzymes, and lactate dehydrogenase (LDH), as well as total antioxidant capacity (T-AOC) and the levels of malonaldehyde (MDA) and hydrogen peroxide (H2O2). We found that DON exposure increased the concentrations of LDH, MDA, and H2O2 in all experimental groups in a dose-dependent manner, while the concentrations of other antioxidant enzymes were decreased...
September 6, 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27600929/selenium-ameliorate-peripheral-nerve-ischemic-reperfusion-injury-via-decreased-tnf-%C3%AE
#10
Abolfazl Zendedel, Zahra Gharibi, Khatereh Anbari, Abolfazl Abbaszadeh, Zahra Khanipour Khayat, Reza Mohammadrezaei Khorramabadi, Maryam Soleymaninejad, Mohammadreza Gholami
Selenium is considered as a trace element that plays antioxidant role in the body. So, the aim of this study was to evaluate the effect of selenium on ameliorating of sciatic nerve ischemia-reperfusion injury. Eighty (80) adult male Wistar rats weighing 250-300 g were used. They were divided into 10 groups (n = 8). Then, femoral vessels were obstructed by using 4/0 silk and splitknot techniques. After 3-h ischemia for all the groups, reperfusion was applied for different periods: 3, 7, 14, and 28 days. In half of each experimental group, 0...
September 6, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27580897/trace-mineral-micronutrients-and-chronic-periodontitis-a-review
#11
Sumit Gaur, Rupali Agnihotri
Trace mineral micronutrients are imperative for optimum host response. Populations worldwide are prone to their insufficiency owing to lifestyle changes or poor nutritional intake. Balanced levels of trace minerals like iron (Fe), zinc (Zn), selenium (Se) and copper (Cu) are essential to prevent progression of chronic conditions like periodontitis. Their excess as well as deficiency is detrimental to periodontal health. This is specifically true in relation to Fe. Furthermore, some trace elements, e.g. Se, Zn and Cu are integral components of antioxidant enzymes and prevent reactive oxygen species induced destruction of tissues...
August 31, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27574687/the-role-of-antioxidant-micronutrients-in-the-rate-of-recovery-of-burn-patients-a-systematic-review
#12
REVIEW
Mary Adjepong, Pius Agbenorku, Patricia Brown, Ibok Oduro
Burn injury can be detrimental to the health of individuals, meanwhile victims lose proteins and micronutrients in wound exudates. Victims also experience extensive protein catabolism. These make them prone to malnutrition. Burn patients also suffer a lot of emotional trauma that reduce nutrient intake. The aim of this paper was to review primary evidence on the effect of antioxidant micronutrients on the recovery rate of burn patients. Electronic databases such as PubMed, BioMed, and Cochrane were systematically searched between January 1, 2014, and January 30, 2014...
2016: Burns and trauma
https://www.readbyqxmd.com/read/27503592/intake-of-antioxidant-nutrients-and-coefficients-of-variation-in-pregnant-women-with-preeclampsia
#13
Alane Cabral Menezes de Oliveira, Arianne Albuquerque Santos, Alexandra Rodrigues Bezerra, Myrian Cicyanne Machado Tavares, Amanda Maria Rocha de Barros, Raphaela Costa Ferreira
INTRODUCTION AND OBJECTIVE: Oxidative stress appears to play a critical role in the pathogenesis of preeclampsia. Evidence suggests that adequate intake of antioxidants can modulate this condition. The objective of this study was to assess the intake of antioxidant nutrients and coefficients of variation in pregnant women with preeclampsia. METHODS: In a cross-sectional study in the public health network of the city of Maceió, Brazil, a dietary survey was performed consisting of 24-hour food recalls, with subsequent adjustment of nutrients using the estimated average requirement as the cutoff point, and a questionnaire on frequency of consumption of antioxidants...
September 2016: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/27350709/selenium-supplementation-for-the-preterm-indian-neonate
#14
Geeta Gathwala, Rahul Aggarwal
Deficient antioxidant defenses in preterm infants have been implicated in diseases such as bronchopulmonary dysplasia, retinopathy of prematurity, necrotizing enterocolitis, periventricular leukomalacia, and intraventricular hemorrhage. The antioxidant properties of selenium make it important in the nutrition of very low-birth weight (VLBW) infants. Selenium is a component of glutathione peroxidase (GPX), an enzyme that prevents the production of free radicals. Preterm infants have low selenium stores and require supplementation by parenteral and enteral routes...
April 2016: Indian Journal of Public Health
https://www.readbyqxmd.com/read/27334437/association-between-antioxidant-intake-status-and-obesity-a-systematic-review-of-observational-studies
#15
Banafshe Hosseini, Ahmad Saedisomeolia, Margaret Allman-Farinelli
The global prevalence of obesity has doubled in recent decades. Compelling evidences indicated that obesity was associated with lower concentrations of specific antioxidants which may play a role in the development of obesity-related diseases such as cardiovascular disease. The present review aimed to synthesize the evidence from studies on the association between obesity and antioxidant micronutrients in a systematic manner. Data bases including MEDLINE, Science Direct, and Cochrane were searched from inception to October 2015...
June 22, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27291351/response-of-selenium-dependent-glutathione-peroxidase-in-the-freshwater-bivalve-anodonta-woodiana-exposed-to-2-4-dichlorophenol-2-4-6-trichlorophenol-and-pentachlorophenol
#16
Xichao Xia, Chunxiu Hua, Shipeng Xue, Bingqin Shi, Gaixia Gui, Dongxian Zhang, Xiying Wang, Lianghong Guo
2,4-dichlorophenol (2,4-DCP), 2,4,6-trichlorophenol (2,4,6-TCP), and pentachlorophenol (PCP) pose a health risk to aquatic organism and humans, and are recognized as persistent priority pollutants. Selenium dependent glutathione peroxidase (Se-GPx) belongs to the family of selenoprotein, which acts mainly as an antioxidant role in the cellular defense system. In the current study, a Se-GPx full length cDNA was cloned from Anodonta woodiana and named as AwSeGPx. It had a characteristic codon at 165TGA167 that corresponds to selenocysteine(Sec) amino acid as U44...
August 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27282980/nf-%C3%AE%C2%BAb-in-acute-pancreatitis-mechanisms-and-therapeutic-potential
#17
REVIEW
Aparna Jakkampudi, Ramaiah Jangala, B Ratnakar Reddy, Sasikala Mitnala, D Nageshwar Reddy, Rupjyoti Talukdar
The incidence of acute pancreatitis (AP) is increasing globally and mortality could be high among patients with organ failure and infected necrosis. The predominant factors responsible for the morbidity and mortality of AP are systemic inflammatory response syndrome and multiorgan dysfunction. Even though preclinical studies have shown antisecretory agents (somatostatin), antioxidants (S-adenosyl methionine [SAM], selenium), protease inhibitors, platelet activating factor inhibitor (Lexipafant), and anti-inflammatory immunomodulators (eg...
July 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27272715/association-of-serum-selenium-zinc-and-magnesium-levels-with-glycaemic-indices-and-insulin-resistance-in-pre-diabetes-a-cross-sectional-study-from-south-india
#18
Charu Yadav, Poornima A Manjrekar, Ashish Agarwal, Afzal Ahmad, Anupama Hegde, Rukmini Mysore Srikantiah
A growing understanding of antioxidant mechanisms and insulin-like actions of trace elements selenium and zinc has rekindled researchers' interest towards their role in diabetes mellitus, nutritional management of which concentrates predominantly on macronutrient intake. However, selenium studies limiting largely to diabetes have yielded inconsistent results with sparse knowledge in the pre-diabetes population. This hospital-based cross-sectional study screened 300 people who came to the institutional hospital laboratory with fasting plasma glucose and glycosylated haemoglobin requisition over a period of 6 months...
June 6, 2016: Biological Trace Element Research
https://www.readbyqxmd.com/read/27222019/effects-of-il-33-st2-pathway-in-acute-inflammation-on-tissue-damage-antioxidative-parameters-magnesium-concentration-and-cytokines-profile
#19
Marija S Stankovic, Kristina Janjetovic, Milica Velimirovic, Marina Milenkovic, Tihomir Stojkovic, Nela Puskas, Ivan Zaletel, Silvio R De Luka, Sasa Jankovic, Srdjan Stefanovic, Nina Japundzic-Zigon, Natasa D Petronijevic, Vladimir Trajkovic, Alexander M Trbovich
AIM: The aim of this study was to examine the role of IL-33/ST2 pathway in a pathogenesis of acute inflammation and its effects on tissue damage, antioxidative capacity, magnesium concentration and cytokine profile in acutely inflamed tissue. MATERIAL AND METHODS: Male mice were randomly divided in four groups: wild-type control group (WT-C), ST2 knockout control group (KO-C), wild-type inflammatory group (WT-I), and ST2 knockout inflammatory group (KO-I). Acute inflammation was induced in WT-I and KO-I by intramuscular injection of turpentine oil, while mice in WT-C and KO-C were treated with saline...
August 2016: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/27147084/protective-role-of-biogenic-selenium-nanoparticles-in-immunological-and-oxidative-stress-generated-by-enrofloxacin-in-broiler-chicken
#20
Shubhangi Shirsat, Ambadas Kadam, Rajaram S Mane, Vijaykumar V Jadhav, Manohar K Zate, Mu Naushad, Kwang Ho Kim
Presently most bacteria are becoming antibiotic resistant. Due to this there is a deficiency of potent antibiotics, therefore we have to preserve and improve the efficiency of existing antibiotics by mitigating the side effects. Enrofloxacin (EFX) is an important antimicrobial used in veterinary practice but it is known to exert immune suppression antioxidant stress. In the present study, we report on: (a) the biosynthesis of selenium nanoparticles (Se NPs), and (b) their protective effect in reducing adverse effects of EFX on broiler chicken...
June 7, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
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