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Selenium role as antioxidant

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https://www.readbyqxmd.com/read/28718676/selenium-zinc-copper-cu-zn-ratio-and-total-antioxidant-status-in-the-serum-of-vitiligo-patients-treated-by-narrow-band-ultraviolet-b-phototherapy
#1
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, which pathogenesis is still unknown. Narrow band ultraviolet-B is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. PURPOSE: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo...
July 18, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28673426/transcriptional-and-biochemical-analysis-of-antioxidant-enzymes-in-the-mussel-mytilus-galloprovincialis-during-experimental-exposures-to-the-toxic-dinoflagellate-prorocentrum-lima
#2
M V Prego-Faraldo, L R Vieira, J M Eirin-Lopez, J Méndez, L Guilhermino
The genotoxic and cytotoxic effects of Diarrhetic Shellfish Poisoning (DSP) toxins have been widely investigated in bivalve molluscs, representing the main vectors of these compounds in the Atlantic coast of Europe. DSP toxins are produced by Harmful Algal Blooms (HABs) of Dinophysis and Prorocentrum dinoflagellates, being subsequently accumulated by marine organisms and biomagnified throughout trophic webs. Yet, bivalves display increased resistance to the harmful effects of these toxins during HAB episodes...
June 15, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28650663/overexpression-and-lowexpression-of-selenoprotein-s-impact-ochratoxin-a-induced-porcine-cytotoxicity-and-apoptosis-in-vitro
#3
Fang Gan, Zhihua Hu, Yajiao Zhou, Kehe Huang
Our previous study demonstrated that selenium could alleviate ochratoxin A (OTA)-induced nephrotoxicity in PK15 cells. Selenoprotein S (SelS) has antioxidant activities, but it is unclear whether SelS plays a role in the alleviating effects of selenium on OTA-induced nephrotoxicity. We previously have stably transfected pig pCDNA3.1-SelS to PK15 cells to over-express SelS. Here, we demonstrated that SelS overexpression alleviated OTA-induced cytotoxicity and apoptosis as demonstrated by cell viabilities, LDH activities, Annexin V-bing, caspase 3 activities and apoptotic nuclei...
June 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28587216/selenium-enrichment-of-horticultural-crops
#4
REVIEW
Martina Puccinelli, Fernando Malorgio, Beatrice Pezzarossa
The ability of some crops to accumulate selenium (Se) is crucial for human nutrition and health. Selenium has been identified as a cofactor of the enzyme glutathione peroxidase, which is a catalyzer in the reduction of peroxides that can damage cells and tissues, and can act as an antioxidant. Plants are the first link in the food chain, which ends with humans. Increasing the Se quantity in plant products, including leafy and fruity vegetables, and fruit crops, without exceeding the toxic threshold, is thus a good way to increase animal and human Se intake, with positive effects on long-term health...
June 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28579252/biological-implications-of-selenium-in-adolescent-rats-exposed-to-binge-drinking-oxidative-immunologic-and-apoptotic-balance
#5
M Luisa Ojeda, Olimpia Carreras, Paula Sobrino, M Luisa Murillo, Fátima Nogales
Alcohol intermittent binge drinking (BD) during adolescence decreases the levels of selenium (Se), a trace element that plays a key biological role against oxidative damage in hepatocytes through different selenoproteins such as the antioxidant enzymes glutathione peroxidases (GPx1 and Gpx4) and selenoprotein P (SelP). In this context, it has been found that GPx4 has an essential antioxidant role in mitochondria modulating the apoptosis and NF-kB activation (a factor intimately related to apoptosis and immune function)...
June 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28574428/reduced-dietary-selenium-impairs-vascular-function-by-increasing-oxidative-stress-in-sprague-dawley-rat-aortas
#6
Ana Stupin, Anita Cosic, Sanja Novak, Monika Vesel, Ivana Jukic, Brigita Popovic, Krunoslav Karalic, Zdenko Loncaric, Ines Drenjancevic
This study aimed to determine whether low dietary Se content affects the function and mechanisms mediating the vascular relaxation of rat aortas, and to test the role of oxidative stress in observed differences. Male Sprague Dawley (SD) rats were maintained for 10 weeks on low Se (low-Se group; N = 20) or normal Se content (norm-Se group; N = 20) rat chow. Dose responses to acetylcholine (ACh; 10(-9)-10(-5)M) and the response to reduced pO₂ were tested in noradrenaline-precontracted aortic rings in the absence/presence of the nitric oxide synthase (NOS) inhibitor nitro-l-arginine methyl ester (l-NAME), the cyclooxygenase 1 and 2 (COX-1, 2) inhibitor Indomethacin, and the antioxidative agent Tempol in tissue bath...
June 2, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28463572/nanoparticles-as-potential-clinical-therapeutic-agents-in-alzheimer-s-disease-focus-on-selenium-nanoparticles
#7
REVIEW
Mustafa Nazıroğlu, Salina Muhamad, Laszlo Pecze
In etiology of Alzheimer's disease (AD), involvement of amyloid β (Aβ) plaque accumulation and oxidative stress in the brain have important roles. Several nanoparticles such as titanium dioxide, silica dioxide, silver and zinc oxide have been experimentally using for treatment of neurological disease. In the last decade, there has been a great interest on combination of antioxidant bioactive compounds such as selenium (Se) and flavonoids with the oxidant nanoparticles in AD. We evaluated the most current data available on the physiological effects of oxidant and antioxidant nanoparticles...
July 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28443587/role-of-trace-elements-for-oxidative-status-and-quality-of-human-sperm
#8
Galina Nenkova, Lubomir Petrov, Albena Alexandrova
BACKGROUND: Oxidative stress affects negatively the sperm quality. For maintaining the pro/antioxidative balance, some metal ions (e.g. copper, zinc, iron, selenium), which are co-factors of the antioxidant enzymes, are essential. However, iron and copper could act as prooxidants inducing oxidative damage of spermatozoa. AIMS: This study aims to reveal a possible correlation between the concentrations of some metal ions (iron, copper, zinc, and selenium) in human seminal plasma, oxidative stress, assessed by malondialdehyde (MDA) and total glutathione (tGSH) levels, and semen quality, assessed by the parameters count, motility, and morphology...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28378115/tracing-tellurium-and-its-nanostructures-in-biology
#9
REVIEW
Bijan Zare, Mohammad Nami, Ahmad-Reza Shahverdi
Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te applications continued to emerge in different fields including metallurgy, glass industry, electronics, and applied chemical industries. Along these lines, Te has recently attracted research attention in various fields. Though Te exists in biologic organisms such as microbes, yeast, and human body, its importance and role and some of its potential implications have long been ignored...
April 4, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28362118/dietary-antioxidants-potential-anticancer-agents
#10
REVIEW
Xiayu Wu, Jiaoni Cheng, Xu Wang
There are several extrinsic and intrinsic factors involving reactive oxygen species that play critical roles in tumor development and progression by inducing DNA mutations, genomic instability, and aberrant pro-tumorigenic signaling. There are various essential micronutrients including minerals and vitamins in the diet, which play pivotal roles in maintaining and reinforcing antioxidant performance, affecting the complex network of genes (nutrigenomic approach) and encoding proteins for carcinogenesis. A lot of these antioxidant agents are available as dietary supplements and are predominant worldwide...
May 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28347459/selenium-mediated-protection-in-reversing-the-sensitivity-of-bacterium-to-the-bactericidal-antibiotics
#11
Zhonglei Li, Jun Tan, Lei Shao, Xiaojing Dong, Richard D Ye, Daijie Chen
Inducing production of damaging reactive oxygen species (ROS) is an important criterion to distinguish the bactericidal antibiotics from bacteriostatic antibiotics. Selenoenzymes were generally recognized to be a powerful antioxidant capable of scavenging free radicals, protecting the cells from the harmful effects of ROS. Therefore, the present study was carried out to investigate the selenium (Se)-mediated protection in reversing antibiotic sensitivity and the role of selenoenzymes in alleviating the negative effects of oxidative stress...
May 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28325649/elemental-analysis-of-serum-and-hair-from-pre-eclamptic-south-african-women
#12
K Maduray, J Moodley, C Soobramoney, R Moodley, T Naicker
Pre-eclampsia is a hypertensive disorder that is associated with adverse maternal and perinatal outcomes. It has been proposed that specific trace and macro elements associated with antioxidant activities may also play a contributory role in aetiology of pre-eclampsia. The aim of this study was to measure the concentrations of thirteen different elements in hair and serum samples from women with a diagnosis of pre-eclampsia and compare them with normotensive controls. Venous blood and pubic hair samples were collected from forty-three pre-eclamptic and twenty-three normotensive pregnant women...
September 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28317078/role-of-selenium-from-different-sources-in-prevention-of-pulmonary-arterial-hypertension-syndrome-in-broiler-chickens
#13
A K Zamani Moghaddam, M H Mehraei Hamzekolaei, F Khajali, H Hassanpour
Pulmonary arterial hypertension (PAH) syndrome in broilers is associated with hypoxia, which prevails at high altitude. Oxidative stress is the pathogenic mechanism underlying PAH. Because selenium is key element in the structure of antioxidant enzymes, we evaluated pulmonary hypertensive responses in broiler chickens fed with diets supplemented with organic or nano-selenium. One hundred forty-four broilers (starting at 5 days old) were fed with (i) control group: birds received a standard diet; (ii) nano-selenium group: birds were fed with basal diet supplemented with nano-selenium at 0...
March 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28274870/construction-of-a-cordyceps-sinensis-exopolysaccharide-conjugated-selenium-nanoparticles-and-enhancement-of-their-antioxidant-activities
#14
Yidong Xiao, Qilin Huang, Zhaomin Zheng, Han Guan, Shiyu Liu
A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO3(2-). The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic light scattering (DLS), energy dispersive X-ray (EDX) and wide angle X-ray diffraction (WAXD) measurements. Results revealed that the SeNPs conjugated to EPS were amorphous and could be well dispersed at a size range of 80-125nm...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#15
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28216602/selenium-and-tellurium-based-antioxidants-for-modulating-inflammation-and-effects-on-osteoblastic-activity
#16
Xi Lu, Gemma Mestres, Vijay Pal Singh, Pedram Effati, Jia-Fei Poon, Lars Engman, Marjam Karlsson Ott
Increased oxidative stress plays a significant role in the etiology of bone diseases. Heightened levels of H2O2 disrupt bone homeostasis, leading to greater bone resorption than bone formation. Organochalcogen compounds could act as free radical trapping agents or glutathione peroxidase mimetics, reducing oxidative stress in inflammatory diseases. In this report, we synthesized and screened a library of organoselenium and organotellurium compounds for hydrogen peroxide scavenging activity, using macrophagic cell lines RAW264...
February 14, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28108278/comparison-of-the-redox-chemistry-of-sulfur-and-selenium-containing-analogs-of-uracil
#17
N Connor Payne, Andrew Geissler, Aileen Button, Alexandru R Sasuclark, Alayne L Schroll, Erik L Ruggles, Vadim N Gladyshev, Robert J Hondal
Selenium is present in proteins in the form of selenocysteine, where this amino acid serves catalytic oxidoreductase functions. The use of selenocysteine in nature is strongly associated with redox catalysis. However, selenium is also found in a 2-selenouridine moiety at the wobble position of tRNA(Glu), tRNA(Gln) and tRNA(Lys). It is thought that the modifications of the wobble position of the tRNA improves the selectivity of the codon-anticodon pair as a result of the physico-chemical changes that result from substitution of sulfur and selenium for oxygen...
March 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28087256/manganese-superoxide-dismutase-and-glutathione-peroxidase-1-contribute-to-the-rise-and-fall-of-mitochondrial-reactive-oxygen-species-which-drive-oncogenesis
#18
REVIEW
Dede N Ekoue, Chenxia He, Alan M Diamond, Marcelo G Bonini
Reactive oxygen species (ROS) largely originating in the mitochondria play essential roles in the metabolic and (epi)genetic reprogramming of cancer cell evolution towards more aggressive phenotypes. Recent studies have indicated that the activity of superoxide dismutase (SOD2) may promote tumor progression by serving as a source of hydrogen peroxide (H2O2). H2O2 is a form of ROS that is particularly active as a redox agent affecting cell signaling due to its ability to freely diffuse out of the mitochondria and alter redox active amino acid residues on regulatory proteins...
August 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28074891/intake-of-vitamin-c-vitamin-e-selenium-zinc-and-polyunsaturated-fatty-acids-and-upper-respiratory-tract-infection-a-prospective-cohort-study
#19
S E Raposo, E Fondell, P Ström, O Bälter, S E Bonn, O Nyrén, A Plymoth, K Bälter
BACKGROUND/OBJECTIVES: Antioxidants and polyunsaturated fatty acids (PUFAs) have a role in the human immune defense and may affect the susceptibility to upper respiratory tract infection (URTI). To examine dietary intake of vitamin C, vitamin E, selenium, zinc and PUFAs in relation to URTI incidence in a prospective cohort study. SUBJECTS/METHODS: A total of 1533 Swedish women and men aged 25-64 years were followed for nine months during 2011-2012. Information on dietary intake was assessed through a web-based food frequency questionnaire, and events of URTI were self-reported prospectively as they occurred...
April 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28056992/antioxidant-capacities-of-the-selenium-nanoparticles-stabilized-by-chitosan
#20
Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren, Xiaojing Leng
BACKGROUNDS: Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with zero oxidation state (Se(0)) has captured our attention because of its low toxicity and excellent bioavailability. However, Se(0) is very unstable and easily changes into the inactive form. By now many efforts have been done to protect its stability. And this work was conducted to explore the antioxidant capacities of the stable Se(0) nanoparticles (SeNPs) stabilized using chitosan (CS) with different molecular weights (Mws) (CS-SeNPs)...
January 5, 2017: Journal of Nanobiotechnology
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