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Selenium role as antioxidant

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https://www.readbyqxmd.com/read/29778465/roles-for-selenium-and-selenoprotein-p-in-the-development-progression-and-prevention-of-intestinal-disease
#1
REVIEW
Sarah P Short, Jennifer M Pilat, Christopher S Williams
Selenium (Se) is a micronutrient essential to human health, the function of which is mediated in part by incorporation into a class of proteins known as selenoproteins (SePs). As many SePs serve antioxidant functions, Se has long been postulated to protect against inflammation and cancer development in the gut by attenuating oxidative stress. Indeed, numerous studies over the years have correlated Se levels with incidence and severity of intestinal diseases such as inflammatory bowel disease (IBD) and colorectal cancer (CRC)...
May 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29733976/ebselen-protects-mitochondrial-function-and-oxidative-stress-while-inhibiting-the-mitochondrial-apoptosis-pathway-after-acute-spinal-cord-injury
#2
Zhi-Qiang Jia, San-Qiang Li, Wei-Qiang Qiao, Wen-Zhong Xu, Jian-Wu Xing, Jian-Tao Liu, Hui Song, Zhong-Yang Gao, Bing-Wen Xing, Xi-Jing He
Ebselen is a fat-soluble small molecule and organic selenium compound that regulates the activity of glutathione peroxidase to alleviate mitochondrial oxidative stress and improve mitochondrial function. In the present study, we aimed to investigate the effects of ebselen on mitochondrial oxidative stress response, mitochondrial apotosis, and motor behaviors after spinal cord injury (SCI). We found that ebselen significantly increased the BBB score in motor behavior, thus suggesting a rescue effect of ebselen on motor function after SCI in rats...
May 4, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29730412/detoxification-of-mercury-in-soil-by-selenite-and-related-mechanisms
#3
Thi Anh Thu Tran, Fei Zhou, Wenxiao Yang, Mengke Wang, Quang Toan Dinh, Dan Wang, Dongli Liang
A better understanding of the benefits of selenium (Se) fertilization to alleviate the toxicity of mercury (Hg) on plants and of the underlying mechanisms involved in Hg stress is important for the remediation of soils contaminated by Hg. This study is aimed to explore the effects of the application of selenite to alleviate the toxicity of Hg in soils to plants and related mechanisms involved in this process. The chemical (Hg uptake of pak choi), biological (root and shoot length, root and shoot weight) and physiological effects (antioxidant enzyme activities, non-enzymatic antioxidant contents (proline) and lipid peroxidation products (malondialdehyde)) produced over plants by the application of different doses of Hg and Se to soil has been investigated through a pot experiment, which was conducted with exposure to different dosages of mercuric chloride (0, 1...
May 3, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29704205/analysis-of-the-relationship-between-hemorheologic-parameters-aluminum-manganese-and-selenium-in-smokers
#4
Fatma Ates Alkan, Denizhan Karis, Gulfidan Cakmak, Alev Meltem Ercan
Smoking is a significant risk factor in fatal pathologies including cardio-cerebrovascular and respiratory diseases. Aluminum (Al) is a toxic element without known biological function, but with recognized toxic effects. Manganese (Mn) and selenium (Se) are essential trace elements involved in cellular antioxidant defense mechanisms. Al, Mn, and Se carry out their metabolic activities via blood flow and tissue oxygenation. The structure and number of red blood cells (RBC) play important role in tissue oxygenation throughout blood flow...
April 27, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29662007/micrornas-as-potential-regulators-of-glutathione-peroxidases-expression-and-their-role-in-obesity-and-related-pathologies
#5
REVIEW
Petra Matoušková, Barbora Hanousková, Lenka Skálová
Glutathione peroxidases (GPxs) belong to the eight-member family of phylogenetically related enzymes with different cellular localization, but distinct antioxidant function. Several GPxs are important selenoproteins. Dysregulated GPx expression is connected with severe pathologies, including obesity and diabetes. We performed a comprehensive bioinformatic analysis using the programs miRDB, miRanda, TargetScan, and Diana in the search for hypothetical microRNAs targeting 3'untranslated regions (3´UTR) of GPxs...
April 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652839/selenium-rich-ricegrass-juice-improves-antioxidant-properties-and-nitric-oxide-inhibition-in-macrophage-cells
#6
Rattanamanee Chomchan, Panupong Puttarak, Adelheid Brantner, Sunisa Siripongvutikorn
Ricegrass juice ( Oryza sativa L.) was introduced as a functional food as the consumption of sprouts or seedlings has been claimed to provide high nutritive value. Selenium (Se) is a trace mineral that plays a key role in the human antioxidation scheme. Supplementation of Se into plants is one strategy to enhance plant bioactivities, and the consumption of Se plant foods may confer superior health benefits. In this study, ricegrass juice extract was analyzed for its major phenolic components. The effect of ricegrass juice extracts bio-fortified with 0, 10 and 40 mg Se/L named as RG0, RG10, and RG40, respectively, were investigated for a percentage of cell viability, changes of endogenous antioxidant enzymes, lipid peroxidation, and nitric oxide inhibition in RAW264...
April 13, 2018: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29626605/mechanisms-of-selenium-hyperaccumulation-in-plants-a-survey-of-molecular-biochemical-and-ecological-cues
#7
REVIEW
Leonardo Warzea Lima, Elizabeth A H Pilon-Smits, Michela Schiavon
BACKGROUND: Selenium (Se) is a micronutrient required for many life forms, but toxic at higher concentration. Plants do not have a Se requirement, but can benefit from Se via enhanced antioxidant activity. Some plant species can accumulate Se to concentrations above 0.1% of dry weight and seem to possess mechanisms that distinguish Se from its analog sulfur (S). Research on these so-called Se hyperaccumulators aims to identify key genes for this remarkable trait and to understand ecological implications...
April 4, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29602134/in-vitro-influence-of-selenium-on-the-proliferation-of-and-steroidogenesis-in-goat-luteinized-granulosa-cells
#8
Xiaolei Yao, M A Ei-Samahy, Lijie Fan, Linfeng Zheng, Yuyue Jin, Jing Pang, Guomin Zhang, Zifei Liu, Feng Wang
In this study, we investigated the effects of Selenium (Se) on the proliferation of and steroidogenesis in goat luteinized granulosa cells (LGCs) and elucidated the mechanisms underlying these effects. Our results showed that proliferating cell nuclear antigen (PCNA), Akt, and phosphoinositide 3-kinase (PI3K) were expressed mainly in ovarian oocytes and granulosa cells (GCs). We observed that 5 ng/mL Se significantly stimulated LGC proliferation, which could be attributed to increases in PCNA, cyclin-dependent kinase 1 (CDK1), phosphorylated adenosine monophosphate-activated protein kinase (p-AMPK; Thr172), and phosphorylated Akt (p-Akt; Ser473) and decreases in p21 (P < 0...
March 20, 2018: Theriogenology
https://www.readbyqxmd.com/read/29542192/cyclic-seleninate-esters-spirodioxyselenuranes-and-related-compounds-new-classes-of-biological-antioxidants-that-emulate-glutathione-peroxidase
#9
Thomas George Back, Kai N Sands, Tyler A Tuck
Selenium compounds play an important role in redox homeostasis in living organisms. One of their major functions is to suppress the harmful effects of hydrogen peroxide, hydroperoxides and downstream reactive oxygen species that lead to oxidative stress, which has in turn been implicated in many diseases and degenerative conditions. The glutathione peroxidase (GPx) family of selenoenzymes plays a key protective role by catalyzing the reduction of peroxides with glutathione. Considerable effort has been expended toward the discovery of small-molecule selenium compounds that mimic GPx...
March 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29536218/pharmacological-mechanisms-underlying-gastroprotective-activities-of-binapthyl-diselenide-in-wistar-rats
#10
Mohammad Ibrahim, Musadiq Ibrahim, Niaz Muhammad, Muhammad Ishaq Ali Shah, Gerlânia de Oliveira Leite, Joao B T Rocha
Selenium (Se) is a dietary essential trace element with important biological roles. It is a nutrient related to the complex metabolic and enzymatic functions. Organoselenium compounds have been reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. The antiulcer activity of binapthyl diselenide (NapSe)2 was investigated in ethanol-induced gastric lesions in rats. A number of markers of oxidative stress were examined in rats stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid...
March 13, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29532247/ameliorative-effects-of-selenium-in-zno-np-induced-oxidative-stress-and-hematological-alterations-in-catla-catla
#11
Muhammad Saleem Asghar, Naureen Aziz Qureshi, Farhat Jabeen, Muhammad Saleem Khan, Muhammad Shakeel, Abdul Shakoor Chaudhry
Various applications of zinc oxide nanoparticles (ZnO NPs) can increase pollution in aquatic environments. Consequently, pollution can cause toxicity in fish as indicated by oxidative stress, hematotoxicity, and changes in gill and liver histology. Selenium is known for its antioxidant potential in scavenging the free radicals generated during ZnO NP-induced oxidative stress. This study tested the ameliorative role of selenium against ZnO NP-induced toxicity in freshwater fish Catla catla. Four groups of replicated fish, representing control, selenium-treated, ZnO NP-treated, and ZnO NPs+selenium-treated, were used in this study...
March 12, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29517182/influence-of-selected-dietary-components-on-the-functioning-of-the-human-nervous-system
#12
Agnieszka Wendołowicz, Ewa Stefańska, Lucyna Ostrowska
The diet is directly connected not only with the physical status but also with the functioning of the brain and the mental status. The potentially beneficial nutrients with a protective effect on the nervous system function include amino acids (tryptophan, phenylalanine, tyrosine, taurine), glucose and vitamins C, E, D and beta-carotene, B group vitamins (vitamin B12, vitamin B6, vitamin B4, vitamin B1) and minerals (selenium, zinc, magnesium, sodium, iron, copper, manganese, iodine). The presence of antioxidants in the diet protects against oxidative damage to nervous system cells...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29512029/the-protective-role-of-selenium-in-afb-1-induced-tissue-damage-and-cell-cycle-arrest-in-chicken-s-bursa-of-fabricius
#13
Ping Hu, Zhicai Zuo, Fengyuan Wang, Xi Peng, Ke Guan, Hang Li, Jing Fang, Hengmin Cui, Gang Su, Ping Ouyang, Yi Zhou
Aflatoxin B1 (AFB1 ) is a naturally occurring secondary metabolites of Aspergillus flavus and Aspergillus parasiticus, and is the most toxic form of aflatoxins. Selenium (Se) with antioxidant and detoxification functions is one of the essential trace elements for human beings and animals. This study aims to evaluate the protective effects of Se on AFB1 -induced tissue damage and cell cycle arrest in bursa of Fabricius (BF) of chickens. The results showed that a dietary supplement of 0.4 mg·kg-1 Se alleviated the histological lesions induced by AFB1 , as demonstrated by decreasing vacuoles and nuclear debris, and relieving oxidative stress...
March 6, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29481840/selenium-selenoprotein-p-and-alzheimer-s-disease-is-there-a-link
#14
REVIEW
Nikolay Solovyev, Evgenii Drobyshev, Geir Bjørklund, Yaroslav Dubrovskii, Roman Lysiuk, Margaret P Rayman
The essential trace element, selenium (Se), is crucial to the brain but it may be potentially neurotoxic, depending on dosage and speciation; Se has been discussed for decades in relation to Alzheimer's disease (AD). Selenoprotein P (SELENOP) is a secreted heparin-binding glycoprotein which serves as the main Se transport protein in mammals. In vivo studies showed that this protein might have additional functions such as a contribution to redox regulation. The current review focuses on recent research on the possible role of SELENOP in AD pathology, based on model and human studies...
March 2, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29429736/effect-of-ultrasound-on-size-morphology-stability-and-antioxidant-activity-of-selenium-nanoparticles-dispersed-by-a-hyperbranched-polysaccharide-from-lignosus-rhinocerotis
#15
Wenfei Cai, Ting Hu, Amr M Bakry, Zhaomin Zheng, Yidong Xiao, Qilin Huang
The differences between ultrasonic and non-ultrasonic approaches in synthesizing Lignosus rhinocerotis polysaccharide-selenium nanoparticles (LRP-SeNPs) were compared in terms of size, morphology, stability and antioxidant activity by UV-VIS, FT-IR, X-ray diffraction (XRD), dynamic light scattering (DLS), transmission electron microscopy (TEM), and energy dispersive X-ray (EDX) with high resolution TEM. Results indicated that the SeNPs were associated with the LRP macromolecules in a physical adsorption pattern without breaking chemical bonds, and the ultrasonic treatment reduced the size of SeNPs, narrowed the size distribution as well as improved the stability...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29384387/racial-differences-in-dietary-antioxidant-intake-and-cardiac-event-free-survival-in-patients-with-heart-failure
#16
Jia-Rong Wu, Eun Kyeung Song, Debra K Moser, Terry A Lennie
BACKGROUND: Heart failure is a chronic, burdensome condition with higher re-hospitalization rates in African Americans than Whites. Higher dietary antioxidant intake is associated with lower oxidative stress and improved endothelial function. Lower dietary antioxidant intake in African Americans may play a role in the re-hospitalization disparity between African American and White patients with heart failure. OBJECTIVE: The objective of this study was to examine the associations among race, dietary antioxidant intake, and cardiac event-free survival in patients with heart failure...
April 2018: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29348054/evaluation-of-sulfane-sulfur-bioeffects-via-a-mitochondria-targeting-selenium-containing-near-infrared-fluorescent-probe
#17
Min Gao, Rui Wang, Fabiao Yu, Lingxin Chen
As a crucial member in antioxidant regulatory systems, sulfane sulfur plays essential roles in cytoprotective mechanisms by directly eliminating ROS and altering ROS-mediated redox signaling. Despite the rising interests in sulfane sulfur, there only a few bio-compatible methods are available for its direct detection. Moreover, most of the existing methods cannot meet the requirements of real-time detection due to the reactive and labile chemical properties of sulfane sulfur. Therefore, we strive to clarify the mutual relationship between mitochondria sulfane sulfur and ROS under hypoxia stress...
April 2018: Biomaterials
https://www.readbyqxmd.com/read/29298985/selenium-implications-for-outcomes-in-extremely-preterm-infants
#18
REVIEW
Rachael Tindell, Trent Tipple
Extremely preterm infants are at high risk for morbidities including bronchopulmonary dysplasia, intraventricular hemorrhage, and retinopathy of prematurity likely related to their exposure to reactive oxygen and nitrogen species early in life. Selenium is a trace mineral contributes to the proper function of multiple systems including immunity, redox regulation, and inflammation via the "selenoenzymes" glutathione peroxidase, thioredoxin reductase, and selenoprotein P. Given that selenium accretion via the placenta occurs primarily during the third trimester, preterm neonates are born selenium deficient...
January 3, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29278740/the-a-to-z-of-modulated-cell-patterning-by-mammalian-thioredoxin-reductases
#19
REVIEW
Markus Dagnell, Edward E Schmidt, Elias S J Arnér
Mammalian thioredoxin reductases (TrxRs) are selenocysteine-containing proteins (selenoproteins) that propel a large number of functions through reduction of several substrates including the active site disulfide of thioredoxins (Trxs). Well-known enzymatic systems that in turn are supported by Trxs and TrxRs include deoxyribonucleotide synthesis through ribonucleotide reductase, antioxidant defense through peroxiredoxins and methionine sulfoxide reductases, and redox modulation of a number of transcription factors...
February 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29236516/trace-minerals-intake-risks-and-benefits-for-cardiovascular-health
#20
Noushin Mohammadifard, Karin H Humphries, Carolyn Gotay, Guillermo Mena-Sánchez, Jordi Salas-Salvadó, Ahmad Esmaillzadeh, Andrew Ignaszewski, Nizal Sarrafzadegan
Minerals play a major role in regulating cardiovascular function. Imbalances in electrolyte minerals are frequent and potentially hazardous occurrences that may lead to the development of cardiovascular diseases (CVDs). Transition metals, such as iron, zinc, copper and selenium, play a major role in cell metabolism. However, there is controversy over the effects of dietary and supplemental intake of these metals on cardiovascular risk factors and events. Since their pro-oxidant or antioxidant functions can have different effects on cardiovascular health...
December 13, 2017: Critical Reviews in Food Science and Nutrition
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