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Selenium role as antioxidant

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https://www.readbyqxmd.com/read/28892882/circulating-protein-carbonyls-antioxidant-enzymes-and-related-trace-minerals-among-preterms-with-respiratory-distress-syndrome
#1
Ahmed El-Abd Ahmed, Eman Ahmed Abd-Elmawgood, Mohammed H Hassan
INTRODUCTION: Information about oxidative stress in preterms with Respiratory Distress Syndrome (RDS) is defective, so various researches in this area are required, which may open new roads in understanding the pathogenesis of the disease, hence provide additional helpful therapeutic approaches. AIM: To assess and compare the plasma level of protein carbonyls as a marker for oxidant status and the antioxidant enzymes; Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx) and the related trace minerals in the form of Copper (Cu), Zinc (Zn) and Selenium (Se) as markers for antioxidant status, in preterms with and without RDS...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28880681/synthesis-and-antioxidant-properties-of-lycium-barbarum-polysaccharides-capped-selenium-nanoparticles-using-tea-extract
#2
Wenjing Zhang, Juan Zhang, Dejun Ding, Liping Zhang, Luis Alexandre Muehlmann, Shu-E Deng, Xuedong Wang, Wentong Li, Weifen Zhang
Selenium nanoparticles (SeNPs) have attracted increasing interest over the last decades because of their activities on redox balance in human body. However, the SeNPs tend to aggregate into large clusters, resulting in lower bioactivity, bioavailability and biocompatibility. Surface-capping agents on SeNPs play crucial roles in its stabilization and biological activity. Here, a green synthesis method for the preparation of Lycium barbarum polysaccharides capped SeNPs using green tea extracts as reductants under mild conditions, at room temperature, is reported...
September 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28821244/the-effect-of-dietary-bacterial-organic-selenium-on-growth-performance-antioxidant-capacity-and-selenoproteins-gene-expression-in-broiler-chickens
#3
A M Dalia, T C Loh, A Q Sazili, M F Jahromi, A A Samsudin
BACKGROUND: Selenium (Se) is an essential trace mineral in broilers, which has several important roles in biological processes. Organic forms of Se are more efficient than inorganic forms and can be produced biologically via Se microbial reduction. Hence, the possibility of using Se-enriched bacteria as feed supplement may provide an interesting source of organic Se, and benefit broiler antioxidant system and other biological processes. The objective of this study was to examine the impacts of inorganic Se and different bacterial organic Se sources on the performance, serum and tissues Se status, antioxidant capacity, and liver mRNA expression of selenoproteins in broilers...
August 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28783600/selenium-antagonizes-cadmium-induced-apoptosis-in-chicken-spleen-but-not-involving-nrf2-regulated-antioxidant-response
#4
Menghao Chen, Xiaojing Li, Ruifeng Fan, Changyu Cao, Haidong Yao, Shiwen Xu
The nuclear transcription factor NF-E2-related factor 2 (Nrf2) binds to antioxidant response elements (AREs) and is involved in the regulation of genes participated in defending cells against oxidative damage, which have been confirmed in animal models. Selenium (Se), known as an important element in the regulation of antioxidant activity, can antagonize Cadmium (Cd) toxicity in birds. However, the role of Nrf2 in selenium-cadmium interaction has not been reported in birds. To further explore the mechanism of selenium attenuating spleen toxicity induced by cadmium in chickens, cadmium chloride (CdCl2, 150mg/kg) and sodium selenite (Na2SeO3, 2mg/kg) were co-administrated or individually administered in the diet of chickens for 90 days...
August 4, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28782302/effect-of-in-vitro-selenium-supplementation-on-sperm-quality-in-asthenoteratozoospermic-men
#5
A A Ghafarizadeh, G Vaezi, M A Shariatzadeh, A A Malekirad
Sperm DNA damage, excessive oxidative stress and decrease in motility ‎may lead to low fertilisation or poor‎ assisted reproductive techniques outcomes in asthenoteratozoospermic ‎men. Selenium was considered as essential element for male reproductive functions. Selenium has important role in enzymatic process for elimination of excessive reactive oxygen species and helps to maintain membrane integrity. The aim of this study was to determine the effect of selenium supplementation on sperm quality, DNA fragmentation, mitochondrial membrane potential and membrane lipid peroxidation during sperm sampling in vitro at different times...
August 6, 2017: Andrologia
https://www.readbyqxmd.com/read/28718676/selenium-zinc-copper-cu-zn-ratio-and-total-antioxidant-status-in-the-serum-of-vitiligo-patients-treated-by-narrow-band-ultraviolet-b-phototherapy
#6
Marta Wacewicz, Katarzyna Socha, Jolanta Soroczyńska, Marek Niczyporuk, Piotr Aleksiejczuk, Jolanta Ostrowska, Maria H Borawska
BACKGROUND: Vitiligo is a chronic, depigmenting skin disorder, whose pathogenesis is still unknown. Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used treatment of vitiligo. It was suggested that trace elements may play a role in pathogenesis of vitiligo. AIM: The aim of this study was to estimate the concentration of selenium (Se), zinc (Zn), copper (Cu) and Cu/Zn ratio as well as total antioxidant status (TAS) in the serum of patients with vitiligo...
August 1, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28673426/transcriptional-and-biochemical-analysis-of-antioxidant-enzymes-in-the-mussel-mytilus-galloprovincialis-during-experimental-exposures-to-the-toxic-dinoflagellate-prorocentrum-lima
#7
M V Prego-Faraldo, L R Vieira, J M Eirin-Lopez, J Méndez, L Guilhermino
The genotoxic and cytotoxic effects of Diarrhetic Shellfish Poisoning (DSP) toxins have been widely investigated in bivalve molluscs, representing the main vectors of these compounds in the Atlantic coast of Europe. DSP toxins are produced by Harmful Algal Blooms (HABs) of Dinophysis and Prorocentrum dinoflagellates, being subsequently accumulated by marine organisms and biomagnified throughout trophic webs. Yet, bivalves display increased resistance to the harmful effects of these toxins during HAB episodes...
August 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28650663/overexpression-and-low-expression-of-selenoprotein-s-impact-ochratoxin-a-induced-porcine-cytotoxicity-and-apoptosis-in-vitro
#8
Fang Gan, Zhihua Hu, Yajiao Zhou, Kehe Huang
Our previous study demonstrated that selenium could alleviate ochratoxin A (OTA)-induced nephrotoxicity in PK15 cells. Selenoprotein S (SelS) has antioxidant activities, but it is unclear whether SelS plays a role in the alleviating effects of selenium on OTA-induced nephrotoxicity. We previously have stably transfected pig pCDNA3.1-SelS to PK15 cells to overexpress SelS. Here, we demonstrated that SelS overexpression alleviated OTA-induced cytotoxicity and apoptosis as demonstrated by cell viabilities, LDH activities, Annexin V-bing, caspase 3 activities, and apoptotic nuclei...
August 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28587216/selenium-enrichment-of-horticultural-crops
#9
REVIEW
Martina Puccinelli, Fernando Malorgio, Beatrice Pezzarossa
The ability of some crops to accumulate selenium (Se) is crucial for human nutrition and health. Selenium has been identified as a cofactor of the enzyme glutathione peroxidase, which is a catalyzer in the reduction of peroxides that can damage cells and tissues, and can act as an antioxidant. Plants are the first link in the food chain, which ends with humans. Increasing the Se quantity in plant products, including leafy and fruity vegetables, and fruit crops, without exceeding the toxic threshold, is thus a good way to increase animal and human Se intake, with positive effects on long-term health...
June 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28579252/biological-implications-of-selenium-in-adolescent-rats-exposed-to-binge-drinking-oxidative-immunologic-and-apoptotic-balance
#10
M Luisa Ojeda, Olimpia Carreras, Paula Sobrino, M Luisa Murillo, Fátima Nogales
Alcohol intermittent binge drinking (BD) during adolescence decreases the levels of selenium (Se), a trace element that plays a key biological role against oxidative damage in hepatocytes through different selenoproteins such as the antioxidant enzymes glutathione peroxidases (GPx1 and Gpx4) and selenoprotein P (SelP). In this context, it has been found that GPx4 has an essential antioxidant role in mitochondria modulating the apoptosis and NF-kB activation (a factor intimately related to apoptosis and immune function)...
August 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28574428/reduced-dietary-selenium-impairs-vascular-function-by-increasing-oxidative-stress-in-sprague-dawley-rat-aortas
#11
Ana Stupin, Anita Cosic, Sanja Novak, Monika Vesel, Ivana Jukic, Brigita Popovic, Krunoslav Karalic, Zdenko Loncaric, Ines Drenjancevic
This study aimed to determine whether low dietary Se content affects the function and mechanisms mediating the vascular relaxation of rat aortas, and to test the role of oxidative stress in observed differences. Male Sprague Dawley (SD) rats were maintained for 10 weeks on low Se (low-Se group; N = 20) or normal Se content (norm-Se group; N = 20) rat chow. Dose responses to acetylcholine (ACh; 10(-9)-10(-5)M) and the response to reduced pO₂ were tested in noradrenaline-precontracted aortic rings in the absence/presence of the nitric oxide synthase (NOS) inhibitor nitro-l-arginine methyl ester (l-NAME), the cyclooxygenase 1 and 2 (COX-1, 2) inhibitor Indomethacin, and the antioxidative agent Tempol in tissue bath...
June 2, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28463572/nanoparticles-as-potential-clinical-therapeutic-agents-in-alzheimer-s-disease-focus-on-selenium-nanoparticles
#12
REVIEW
Mustafa Nazıroğlu, Salina Muhamad, Laszlo Pecze
In etiology of Alzheimer's disease (AD), involvement of amyloid β (Aβ) plaque accumulation and oxidative stress in the brain have important roles. Several nanoparticles such as titanium dioxide, silica dioxide, silver and zinc oxide have been experimentally using for treatment of neurological disease. In the last decade, there has been a great interest on combination of antioxidant bioactive compounds such as selenium (Se) and flavonoids with the oxidant nanoparticles in AD. We evaluated the most current data available on the physiological effects of oxidant and antioxidant nanoparticles...
July 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28443587/role-of-trace-elements-for-oxidative-status-and-quality-of-human-sperm
#13
Galina Nenkova, Lubomir Petrov, Albena Alexandrova
BACKGROUND: Oxidative stress affects negatively the sperm quality. For maintaining the pro/antioxidative balance, some metal ions (e.g. copper, zinc, iron, selenium), which are co-factors of the antioxidant enzymes, are essential. However, iron and copper could act as prooxidants inducing oxidative damage of spermatozoa. AIMS: This study aims to reveal a possible correlation between the concentrations of some metal ions (iron, copper, zinc, and selenium) in human seminal plasma, oxidative stress, assessed by malondialdehyde (MDA) and total glutathione (tGSH) levels, and semen quality, assessed by the parameters count, motility, and morphology...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28378115/tracing-tellurium-and-its-nanostructures-in-biology
#14
REVIEW
Bijan Zare, Mohammad Nami, Ahmad-Reza Shahverdi
Tellurium (Te) is a semimetal rare element in nature. Together with oxygen, sulfur (S), and selenium (Se), Te is considered a member of chalcogen group. Over recent decades, Te applications continued to emerge in different fields including metallurgy, glass industry, electronics, and applied chemical industries. Along these lines, Te has recently attracted research attention in various fields. Though Te exists in biologic organisms such as microbes, yeast, and human body, its importance and role and some of its potential implications have long been ignored...
April 4, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28362118/dietary-antioxidants-potential-anticancer-agents
#15
REVIEW
Xiayu Wu, Jiaoni Cheng, Xu Wang
There are several extrinsic and intrinsic factors involving reactive oxygen species that play critical roles in tumor development and progression by inducing DNA mutations, genomic instability, and aberrant pro-tumorigenic signaling. There are various essential micronutrients including minerals and vitamins in the diet, which play pivotal roles in maintaining and reinforcing antioxidant performance, affecting the complex network of genes (nutrigenomic approach) and encoding proteins for carcinogenesis. A lot of these antioxidant agents are available as dietary supplements and are predominant worldwide...
May 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28347459/selenium-mediated-protection-in-reversing-the-sensitivity-of-bacterium-to-the-bactericidal-antibiotics
#16
Zhonglei Li, Jun Tan, Lei Shao, Xiaojing Dong, Richard D Ye, Daijie Chen
Inducing production of damaging reactive oxygen species (ROS) is an important criterion to distinguish the bactericidal antibiotics from bacteriostatic antibiotics. Selenoenzymes were generally recognized to be a powerful antioxidant capable of scavenging free radicals, protecting the cells from the harmful effects of ROS. Therefore, the present study was carried out to investigate the selenium (Se)-mediated protection in reversing antibiotic sensitivity and the role of selenoenzymes in alleviating the negative effects of oxidative stress...
May 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28325649/elemental-analysis-of-serum-and-hair-from-pre-eclamptic-south-african-women
#17
K Maduray, J Moodley, C Soobramoney, R Moodley, T Naicker
Pre-eclampsia is a hypertensive disorder that is associated with adverse maternal and perinatal outcomes. It has been proposed that specific trace and macro elements associated with antioxidant activities may also play a contributory role in aetiology of pre-eclampsia. The aim of this study was to measure the concentrations of thirteen different elements in hair and serum samples from women with a diagnosis of pre-eclampsia and compare them with normotensive controls. Venous blood and pubic hair samples were collected from forty-three pre-eclamptic and twenty-three normotensive pregnant women...
September 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28317078/role-of-selenium-from-different-sources-in-prevention-of-pulmonary-arterial-hypertension-syndrome-in-broiler-chickens
#18
A K Zamani Moghaddam, M H Mehraei Hamzekolaei, F Khajali, H Hassanpour
Pulmonary arterial hypertension (PAH) syndrome in broilers is associated with hypoxia, which prevails at high altitude. Oxidative stress is the pathogenic mechanism underlying PAH. Because selenium is key element in the structure of antioxidant enzymes, we evaluated pulmonary hypertensive responses in broiler chickens fed with diets supplemented with organic or nano-selenium. One hundred forty-four broilers (starting at 5 days old) were fed with (i) control group: birds received a standard diet; (ii) nano-selenium group: birds were fed with basal diet supplemented with nano-selenium at 0...
March 20, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28274870/construction-of-a-cordyceps-sinensis-exopolysaccharide-conjugated-selenium-nanoparticles-and-enhancement-of-their-antioxidant-activities
#19
Yidong Xiao, Qilin Huang, Zhaomin Zheng, Han Guan, Shiyu Liu
A Cordyceps sinensis exopolysaccharide (EPS)-conjugated selenium nanoparticles (SeNPs) were successfully constructed through the reduction of SeO3(2-). The EPS-SeNPs were characterized in terms of formation, morphology, size, Se distribution and phase by UV-vis, FT-IR, transmission electron microscopy (TEM), dynamic light scattering (DLS), energy dispersive X-ray (EDX) and wide angle X-ray diffraction (WAXD) measurements. Results revealed that the SeNPs conjugated to EPS were amorphous and could be well dispersed at a size range of 80-125nm...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#20
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
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