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https://www.readbyqxmd.com/read/29230860/cardiac-gating-using-scattering-of-an-8-channel-parallel-transmit-coil-at-7t
#1
Sven H F Jaeschke, Matthew D Robson, Aaron T Hess
PURPOSE: To establish a cardiac signal from scattering matrix or scattering coefficient measurements made on a 7T 8-channel parallel transmit (pTx) system, and to evaluate its use for cardiac gating. METHODS: Measurements of the scattering matrix and scattering coefficients were acquired using a monitoring pulse sequence and during a standard cine acquisition, respectively. Postprocessing used an independent component analysis and gating feature identification. The effect of the phase of the excitation radiofrequency (RF) field ( B1+ shim) on the cardiac signal was simulated for multiple B1+ shim configurations, and cine images were reconstructed from both the scattering coefficients and electrocardiogram (ECG)...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29227281/targeting-mcl-1-enhances-dna-replication-stress-sensitivity-to-cancer-therapy
#2
Guo Chen, Andrew T Magis, Ke Xu, Dongkyoo Park, David S Yu, Taofeek K Owonikoko, Gabriel L Sica, Sarah W Satola, Suresh S Ramalingam, Walter J Curran, Paul W Doetsch, Xingming Deng
DNA double-strand breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways. Here, we showed that myeloid cell leukemia sequence 1 (Mcl-1) acts as a functional switch in selecting between HR and NHEJ pathways. Mcl-1 was cell cycle-regulated during HR, with its expression peaking in S/G2 phase. While endogenous Mcl-1 depletion reduced HR and enhanced NHEJ, Mcl-1 overexpression resulted in a net increase in HR over NHEJ. Mcl-1 directly interacted with the dimeric Ku protein complex via its Bcl-2 homology 1 and 3 (BH1 and BH3) domains, which are required for Mcl-1 to inhibit Ku-mediated NHEJ...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29225104/evaluation-of-qt-dispersion-and-t-peak-to-t-end-interval-in-patients-with-early-stage-sarcoidosis
#3
Hacı Ahmet Kasapkara, Ayşegül Şentürk, Emine Bilen, Hüseyin Ayhan, Bilge Duran Karaduman, Zeynep Şeyma Turinay, Murat Can Güney, Tahir Durmaz, Telat Keleş, Engin Bozkurt
INTRODUCTION AND AIM: Sarcoidosis increases inhomogeneity in ventricular repolarization due to the presence of sarcoid granuloma, which significantly correlates with ventricular fibrillation. Various studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (T-peak to T-end [Tpe] interval) may correspond to the transmural dispersion of repolarization and that increased Tpe interval and Tpe/QT ratio are associated with malignant ventricular arrhythmias...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29220728/assessment-of-long-term-exposure-to-airborne-dioxin-and-cadmium-concentrations-in-the-lyon-metropolitan-area-france
#4
T Coudon, H Hourani, C Nguyen, E Faure, F R Mancini, B Fervers, P Salizzoni
Identifying the long-term effects of airborne pollutants requires the computation of the spatial and temporal variability of their concentration in air to estimate the exposure of the population. To estimate exposure levels of individuals in a breast cancer case control study nested in a national prospective cohort, we determine here the differential impact of a variety of cadmium and dioxin sources on urban air over a large urban area and over a period of almost 20years. To that end, we couple an emission model, to estimate dioxin and cadmium atmospheric annual releases, with an urban dispersion model in order to compute pollutant concentration fields at a fine temporal (1h) and spatial (25m) resolution...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29214506/pharmacokinetics-of-oral-and-intravenous-paracetamol-acetaminophen-when-co-administered-with-intravenous-morphine-in-healthy-adult-subjects
#5
Robert B Raffa, Jayne Pawasauskas, Joseph V Pergolizzi, Luke Lu, Yin Chen, Sutan Wu, Brant Jarrett, Randi Fain, Lawrence Hill, Krishna Devarakonda
BACKGROUND AND OBJECTIVE: Several features favor paracetamol (acetaminophen) administration by the intravenous rather than the oral route in the postoperative setting. This study compared the pharmacokinetics and bioavailability of oral and intravenous paracetamol when given with or without an opioid, morphine. METHODS: In this randomized, single-blind, parallel, repeat-dose study in healthy adults, subjects received four repeat doses of oral or intravenous 1000 mg paracetamol at 6-h intervals, and morphine infusions (0...
December 6, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29202847/effects-of-adenosine-and-regadenoson-on-hemodynamics-measured-using-cardiovascular-magnetic-resonance-imaging
#6
Dustin M Thomas, Matthew R Minor, James K Aden, Christopher J Lisanti, Kevin E Steel
BACKGROUND: Adenosine or regadenoson vasodilator stress cardiovascular magnetic resonance (CMR) is an effective non-invasive strategy for evaluating symptomatic coronary artery disease. Vasodilator injection typically precedes ventricular functional sequences to efficiently reduce overall scanning times, though the effects of vasodilators on CMR-derived ventricular volumes and function are unknown. METHODS: We prospectively enrolled 25 healthy subjects to undergo consecutive adenosine and regadenoson administration...
December 4, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29201434/influence-of-longitudinal-position-on-the-evolution-of-steady-state-signal-in-cardiac-cine-balanced-steady-state-free-precession-imaging
#7
Tyler J Spear, Tori A Stromp, Steve W Leung, Moriel H Vandsburger
Background: Emerging quantitative cardiac magnetic resonance imaging (CMRI) techniques use cine balanced steady-state free precession (bSSFP) to measure myocardial signal intensity and probe underlying physiological parameters. This correlation assumes that steady-state is maintained uniformly throughout the heart in space and time. Purpose: To determine the effects of longitudinal cardiac motion and initial slice position on signal deviation in cine bSSFP imaging by comparing two-dimensional (2D) and three-dimensional (3D) acquisitions...
November 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/29197146/is-myocardial-repolarization-duration-associated-with-repolarization-heterogeneity
#8
Keith A Marill, Pat Dorsey, Anthony Holmes, Ketaki Muthal, Emily S Miller, Joel Xue
BACKGROUND: Dispersion of repolarization is theorized as one mechanism by which myocardial repolarization prolongation causes lethal torsades de pointes, (TdP). Our primary purpose was to determine whether prolongation of myocardial repolarization as measured by the heart rate-corrected J-to-T peak interval (JTpkc), is associated with repolarization heterogeneity as measured by transmural dispersion, defined as the median duration from the peak to the end of the T wave (TpTe). METHODS: A retrospective cohort study was performed at a single urban tertiary ED from July 2011-September 2012...
December 2, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29194862/a-case-report-is-mexiletine-usage-effective-in-the-shortening-of-qtc-interval-and-improving-the-t-wave-alternans-in-timothy-syndrome
#9
Gulhan Tunca Sahin, Yakup Ergul
Timothy syndrome (TS) is a multisystemic disease that occurs because of a mutation in CACN1C gene and is characterized by prolonged QT interval. Mexiletine is a Class 1B antiarrhythmic drug that causes the disappearance of T-wave alternans by shortening QTc and peak-to-end of the T wave. It may block the development of torsades de pointes in a prolonged QT. This study presented the case of a patient diagnosed with TS and had a cardiac arrest history, prolonged QT, and T-wave alternans. After mexiletine treatment, the QTc interval shortened and T-wave alternans disappeared...
November 30, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29194447/sevoflurane-causes-greater-qtc-interval-prolongation-in-chronically-hyperglycemic-patients-than-in-normoglycemic-patients
#10
Seishi Kimura, Shinichi Nakao, Atsuhiro Kitaura, Tatushige Iwamoto, Kei Houri, Mayuka Matsushima, Shinichi Hamasaki
QTc interval prolongation is a serious diabetic complication and increases mortality rate. Hyperglycemia inhibits the rapid component of delayed rectifier potassium channel currents (Ikr) and prolongs the QTc interval on electrocardiograms. Sevoflurane also inhibits the Ikr and causes QTc interval prolongation. In fact, torsade de pointes occurred in a patient with poorly controlled diabetes mellitus during sevoflurane anesthesia. We enrolled 74 patients, including 37 normoglycemic patients (glycated hemoglobin [HbA1c]: <6...
2017: PloS One
https://www.readbyqxmd.com/read/29184789/effect-of-collagenase-clostridium-histolyticum-on-penile-vascular-and-morphological-parameters-in-patients-with-peyronie-s-disease
#11
Linley Diao, James Anaissie, Hoang Minh Tue Nguyen, Faysal A Yafi, Nora M Haney, Kenneth J DeLay, Taylor C Peak, Suresh C Sikka, Wayne J G Hellstrom
Background: To examine the changes in penile vascular parameters after the administration of collagenase Clostridium histolyticum (CCH) in patients with Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017 who underwent penile duplex Doppler ultrasound (PDDU) after pharmacologically induced erection both before and after four cycles of CCH treatment. The primary outcomes measured were changes in peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) after CCH treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29183815/bioscavenger-is-effective-as-a-delayed-therapeutic-intervention-following-percutaneous-vx-poisoning-in-the-guinea-pig
#12
T M Mann, M E Price, C L Whitmore, R L Perrott, T R Laws, R R McColm, E R Emery, J E H Tattersall, A C Green, H Rice
The prolonged systemic exposure that follows skin contamination with low volatility nerve agents, such as VX, requires treatment to be given over a long time due to the relatively short half-lives of the therapeutic compounds used. Bioscavengers, such as butyrylcholinesterase (BChE), have been shown to provide effective post-exposure protection against percutaneous nerve agent when given immediately on signs of poisoning and to reduce reliance on additional treatments. In order to assess the benefits of administration of bioscavenger at later times, its effectiveness was assessed when administration was delayed for 2h after the appearance of signs of poisoning in guinea-pigs challenged with VX (4×LD50)...
November 25, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29170001/heightened-cortisol-response-to-exercise-challenge-in-women-with-functional-hypothalamic-amenorrhea
#13
Kristen M Sanders, Jennifer F Kawwas, Tammy Loucks, Sarah L Berga
BACKGROUND: Functional hypothalamic amenorrhea is characterized by anovulation due to reduced gonadotropin-releasing hormone drive and is associated with hypercortisolemia that has been linked to heightened hypothalamic-pituitary-adrenal reactivity to common psychological and metabolic challenges. OBJECTIVE: We hypothesized that women with functional hypothalamic amenorrhea would display greater cortisol responses to exercise challenge than ovulatory, eumenorrheic women...
November 20, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29168072/estimates-for-the-acoustical-stimulation-and-heating-of-multiphase-biotissue
#14
T I Zohdi, R Krone
Low-intensity, unfocused, ultrasound-induced diathermy can produce undesired temperature increases at the interface of adjacent tissues within the body; particularly, at the interface of soft tissue and bone. This study provides a computational framework for predicting an upper bound on the temperature profile within a multiphase system composed of gel pad (water), tissue and bone from an input of acoustic energy, at frequencies and power levels consistent with applications of therapeutic hyperthermia. The model consists of solving a (one-dimensional) spatially discretized bioheat transfer equation via finite-difference method and updating the solution in time with a forward-Euler scheme...
November 22, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29163532/biodistribution-and-immunogenicity-of-allogeneic-mesenchymal-stem-cells-in-a-rat-model-of-intraarticular-chondrocyte-xenotransplantation
#15
Maribel Marquina, Javier A Collado, Magdiel Pérez-Cruz, Pablo Fernández-Pernas, Juan Fafián-Labora, Francisco J Blanco, Rafael Máñez, María C Arufe, Cristina Costa
Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic chondrocytes when injected intraarticularly, as well as the immunoregulatory effect of allogeneic bone marrow-derived MSC after systemic administration. To this end, a discordant xenotransplantation model was established by injecting three million porcine articular chondrocytes (PAC) into the femorotibial joint of Lewis rats and monitoring the immune response...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29151301/assessment-of-repolarization-abnormalities-in-baseline-electrocardiograms-of-patients-with-myocarditis
#16
Hacı Murat Güneş, Gamze Babur Güler, Ekrem Güler, Gültekin Günhan Demir, Mehmet Kamil Teber, Filiz Kızılırmak, Beytullah Çakal, Bilal Boztosun
Background/aim: Myocarditis in the acute phase usually presents with sinus tachycardia but many other arrhythmias might be seen as well. In this study we aimed to investigate repolarization abnormalities in baseline ECG of patients with myocarditis for the first time.Materials and methods: Thirty patients diagnosed with myocarditis and 25 healthy age-matched controls were included. Two different cardiologists measured corrected QT (QTc), QT dispersion (QTd), QT peak (QTp), T wave peak to T wave end (TpTe), TpTe/QT ratio, and TpTe/QTc ratio in 12-lead ECG...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29139031/in-vivo-analysis-of-the-anti-atrial-fibrillatory-proarrhythmic-and-cardiodepressive-profiles-of-dronedarone-as-a-guide-for-safety-pharmacological-evaluation-of-antiarrhythmic-drugs
#17
Yoshiyuki Motokawa, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T Naito, Hiroshi Yamazaki, Atsushi Sugiyama
Anti-atrial fibrillatory, proarrhythmic and cardiodepressive profiles of dronedarone were analyzed using the halothane-anesthetized beagle dogs (n = 4) to create a standard protocol for clarifying both efficacy and adverse effects of anti-atrial fibrillatory drugs. Intravenous administration of dronedarone hydrochloride in doses of 0.3 and 3 mg/kg over 30 s attained the peak plasma concentrations of 61 and 1248 ng/mL, respectively, reflecting sub- to supra-therapeutic ones. The low dose decreased the left ventricular contraction and mean blood pressure, which were enhanced at the high dose...
November 14, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29125109/impact-of-myocardial-bridge-mural-coronary-artery-on-myocardial-functions
#18
Xin-Bin Zhao, Yu Fu, Jie Li, Meng Sun, He-Liang Zhao
Objective To study the impact of myocardial bridge (MB)-mural coronary artery (MCA) on myocardial functions.Methods Totally 82 patients presenting with chest tightness and chest pain who were diagnosed with the MB in the left anterior descending artery by CT coronary angiography were enrolled as the MB group,in which the thickness and length of MB and the systolic stenosis degree of MCA were measured.In addition,82 healthy subjects,as confirmed by health check-up,were set as the control group.The age,gender,body mass index (BMI),heart rate (HR),smoking history,interventricular septal thickness,left ventricular posterior wall thickness,diameter of left atrium,left ventricular end-diastolic diameter,left ventricular end-systolic diameter,left ventricular ejection fraction,and the cases of E'/A'<1 were compared between MB group and control group...
October 30, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29122952/organ-level-validation-of-a-cross-bridge-cycling-descriptor-in-a-left-ventricular-finite-element-model-effects-of-ventricular-loading-on-myocardial-strains
#19
Sheikh Mohammad Shavik, Samuel T Wall, Joakim Sundnes, Daniel Burkhoff, Lik Chuan Lee
Although detailed cell-based descriptors of cross-bridge cycling have been applied in finite element (FE) heart models to describe ventricular mechanics, these multiscale models have never been tested rigorously to determine if these descriptors, when scaled up to the organ-level, are able to reproduce well-established organ-level physiological behaviors. To address this void, we here validate a left ventricular (LV) FE model that is driven by a cell-based cross-bridge cycling descriptor against key organ-level heart physiology...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29115949/neurally-adjusted-ventilatory-assist-nava-or-pressure-support-ventilation-psv-during-spontaneous-breathing-trials-in-critically-ill-patients-a-crossover-trial
#20
Juliana C Ferreira, Fabia Diniz-Silva, Henrique T Moriya, Adriano M Alencar, Marcelo B P Amato, Carlos R R Carvalho
BACKGROUND: Neurally Adjusted Ventilatory Assist (NAVA) is a proportional ventilatory mode that uses the electrical activity of the diaphragm (EAdi) to offer ventilatory assistance in proportion to patient effort. NAVA has been increasingly used for critically ill patients, but it has not been evaluated during spontaneous breathing trials (SBT). We designed a pilot trial to assess the feasibility of using NAVA during SBTs, and to compare the breathing pattern and patient-ventilator asynchrony of NAVA with Pressure Support (PSV) during SBTs...
November 7, 2017: BMC Pulmonary Medicine
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