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JOURNAL ARTICLE
Jing Xie, Xiaoli Long, Jiwen Xie, Dongxia Yang, Jun Yang, Xiaoting Mao
OBJECTIVE: To explore the correlation between left ventricular global longitudinal strain (LVGLS) and major adverse cardiovascular event (MACE) occurrence in patients with end-stage renal disease (ESRD). METHODS: From January 2019 to December 2023, ESRD patients undergoing maintenance dialysis and LVGLS measurement admitted to the First People's Hospital of Lanzhou City were selected as subjects. They were followed up for 12 months to record the occurrence of MACEs, and divided into MACE group and non-MACE group according to MACE presence or absence...
April 17, 2024: International Urology and Nephrology
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JOURNAL ARTICLE
Jagdip Kang, Alexandro Hoyer, Maja-Theresa Dieterlen, Hanna Oetzel, Wolfgang Otto, André Ginther, Bettina PfannmüLler, Martin Misfeld, Thilo Noack, Philipp Kiefer, Michael A Borger
OBJECTIVES: In this study, we evaluated if modified Del Nido cardioplegia delivers comparable cardiac protection in comparison to Custodiol® in patients undergoing isolated minimally invasive mitral valve repair. METHODS: From 01/2018 to 10/2021 all patients undergoing non emergent isolated minimally invasive mitral valve repair were included in this study. The cardioplegia was chosen at the surgeons' discretion. The primary end-points of this study were peak postoperative cardiac enzyme levels...
April 16, 2024: European Journal of Cardio-thoracic Surgery
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JOURNAL ARTICLE
Zhen Zhang, Dongqing Wang
Multiagent reinforcement learning (MARL) has been extensively applied to coordination optimization for its task distribution and scalability. The goal of the MARL algorithms for coordination optimization is to learn the optimal joint strategy that maximizes the expected cumulative reward of all agents. Some cooperative MARL algorithms exhibit exciting characteristics in empirical studies. However, the majority of the convergence results are confined to repeated games. Moreover, few MARL algorithms consider adaptation to the switched environments such as the alternation between peak hours and off-peak hours of urban traffic flow or an obstacle suddenly appearing on the planned route for the automated guided vehicle...
April 16, 2024: IEEE Transactions on Neural Networks and Learning Systems
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JOURNAL ARTICLE
Xiaoling Wen, Yue Gao, Yingkun Guo, Yi Zhang, Yan Zhang, Ke Shi, Yuan Li, Zhigang Yang
BACKGROUND: Although it is known that mitral regurgitation (MR) in patients with myocardial infarction (MI) may increase the right ventricular (RV) afterload, leading to RV dysfunction, the exact detrimental effects on RV function and myocardial peak strain remain unresolved. In this study, we assessed the impact of MR on the impairment of RV myocardial deformation in patients with MI and explored the independent influential factors of RV peak strain. METHODS: A total of 199 MI participants without or with MR were retrospectively assessed in this study...
April 3, 2024: Quantitative Imaging in Medicine and Surgery
#5
JOURNAL ARTICLE
Sarah K Nørgaard, Jens Nielsen, Anne Christine Nordholm, Lukas Richter, Alena Chalupka, Natalia Bustos Sierra, Toon Braeye, Maria Athanasiadou, Theodore Lytras, Gleb Denissov, Oskari Luomala, Anne Fouillet, Isabelle Pontais, Matthias An der Heiden, Benedikt Zacher, Alina Weigel, Ivo Foppa, Kassiani Gkolfinopoulou, Ioannis Panagoulias, Anna Paldy, Tibor Malnasi, Lisa Domegan, Eva Kelly, Naama Rotem, Oksana Rakhlin, Francesca K de'Donato, Chiara Di Blasi, Patrick Hoffmann, Telma Velez, Kathleen England, Neville Calleja, Liselotte van Asten, Femke Jongenotter, Ana Paula Rodrigues, Susana Silva, Petra Klepac, Diana Gomez-Barroso, Inmaculada Leon Gomez, Ilias Galanis, Ahmed Farah, Rolf Weitkunat, Katarina Fehst, Nick Andrews, Tom Clare, Declan T Bradley, Mark G O'Doherty, Naoma William, Mark Hamilton, Bolette Søborg, Tyra G Krause, Nick Bundle, Lasse S Vestergaard
Since the end of November 2023, the European Mortality Monitoring Network (EuroMOMO) has observed excess mortality in Europe. During weeks 48 2023-6 2024, preliminary results show a substantially increased rate of 95.3 (95% CI: 91.7-98.9) excess all-cause deaths per 100,000 person-years for all ages. This excess mortality is seen in adults aged 45 years and older, and coincides with widespread presence of COVID-19, influenza and respiratory syncytial virus (RSV) observed in many European countries during the 2023/24 winter season...
April 2024: Euro Surveillance
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JOURNAL ARTICLE
Robert M Gifford, N Taylor, A Carroll, J Sweeting, I T Parsons, M J Stacey, N Z M Homer, A Tsanas, D R Woods, R M Reynolds
INTRODUCTION: Measuring cortisol during military training offers insights into physiological responses to stress. We attempted precisely timed, cortisol awakening response (CAR) and pre-sleep cortisol (PSC), and diurnal slope (peak morning minus evening cortisol), during a British Army exercise. We aimed to understand cortisol dynamics and evaluate the feasibility of CAR and PSC in this environment. METHOD: Setting: high-intensity, 10-day infantry exercise. Participants: regular infantry soldiers exercising (EX, n=25) or headquarters-based (HQ, n=6)...
April 11, 2024: BMJ military health
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JOURNAL ARTICLE
J Cui, W Liu, F Yan, Y Zhao, W Chen, C Luo, X Zhang, T Li
OBJECTIVE: To assess the value of cardiac magnetic resonance (CMR) imaging for predicting adverse left ventricular remodeling in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: We retrospectively analyzed the clinical data and serial CMR (cine and LGE sequences) images of 86 STEMI patients within 1 week and 5 months after percutaneous coronary intervention (PCI), including 25 patients with adverse LV remodeling and 61 without adverse LV remodeling, defined as an increase of left ventricular end-systolic volume (LVESV) over 15% at the second CMR compared to the initial CMR...
March 20, 2024: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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JOURNAL ARTICLE
Daniel Shats, Tara Balasubramanian, Danielle Sidelnikov, Urjita Das, Ndidi-Amaka Onyekaba, He E Forbes, Noela Lu, Kristin Williams, Moran R Levin, Sripriya Sundararajan, Shitiz Vij, Hrishikesh Gadagkar, Abhishek Rege, Osamah Saeedi, Victoria Chen, Janet L Alexander
PURPOSE: To determine the correlation between blood flow metrics measured by intravenous fluorescein angiography (IVFA) and the blood flow velocity index (BFVi) obtained by laser speckle contrast imaging (LSCI) in infants with retinopathy of prematurity (ROP). DESIGN: Prospective comparative pilot study. SUBJECTS: Seven eyes from 7 subjects with ROP. METHODS: Unilateral LSCI and IVFA data were obtained from each subject in the neonatal intensive care unit...
2024: Ophthalmol Sci
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JOURNAL ARTICLE
Nart Zafer Baytugan, Hasan Çağlayan Kandemir
BACKGROUND: The control of the cardiovascular system depends on the autonomic nerve system. Chronic anabolic andorogenic steroids (AAS) use causes sympathovagal imbalance and increases sympathetic nerve activity. OBJECTIVE: The reduction in heart rate from the peak exercise rate following the end of the exercise stress test is known as the heart rate recovery index (HRRI). Several methods have been utilized to assess myocardial repolarization, such as QT interval (QT), corrected QT interval (QTc), and T-wave peak-to-end interval (Tp-e interval)...
April 1, 2024: Journal of Electrocardiology
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REVIEW
Rivka Dresner-Pollak
Advances in monitoring and treatment of people living with Type 1 Diabetes (T1D) have led to longer life expectancy, but with it an ageing population of T1D patients with age-associated conditions. While diabetic macrovascular, brain, eye, nerve and kidney complications are widely recognized, bone fragility with concomitant fracture has received considerably less attention, even though bone fractures lead to very high morbidity and mortality. Hip fracture risk is up to 6-fold higher in T1D compared to age- and sex-matched non-diabetic controls and is significantly higher than in type 2 diabetes...
March 29, 2024: Endocrine Practice
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JOURNAL ARTICLE
Tao Liu, Shubhangi Vairagar, Sushadevi Adagale, T Karthick, Catherine Esther Karunya, John Blesswin A, Selva Mary G
The secure authentication of user data is crucial in various sectors, including digital banking, medical applications and e-governance, especially for images. Secure communication protects against data tampering and forgery, thereby bolstering the foundation for informed decision-making, whether managing traffic, enhancing public safety, or monitoring environmental conditions. Conventional visual cryptographic protocols offer solutions, particularly for color images, though they grapple with challenges such as high computational demands and reliance on multiple cover images...
February 29, 2024: Mathematical Biosciences and Engineering: MBE
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RANDOMIZED CONTROLLED TRIAL
Wen Zhang, Hai-Tao Jin, Fei Wang, Jing-Lan Zhang, Yuan Bao, Song Wang
BACKGROUND: Swallowing rehabilitation behavioral therapy and traditional Chinese acupuncture therapy are widely used in the treatment of post-stroke dysphagia (PSD). This study investigated the therapeutic effect of electro-acupuncture combined with exercise-based swallowing rehabilitation on PSD and its effect on brainstem auditory evoked potential (BAEP) and cerebral blood flow. METHODS: The 120 PSD patients were divided into 2 groups (n = 60 each) by simple random grouping method, that is, an experimental and control group, receiving routine swallowing training, or additional intervention with electro-acupuncture at a frequency of 5 times/week...
March 15, 2024: Medicine (Baltimore)
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JOURNAL ARTICLE
Osman Akdag, Pim T S Borman, Stefano Mandija, Peter L Woodhead, Prescilla Uijtewaal, Bas W Raaymakers, Martin F Fast
BACKGROUND: Cardiac radioablation is a noninvasive stereotactic body radiation therapy (SBRT) technique to treat patients with refractory ventricular tachycardia (VT) by delivering a single high-dose fraction to the VT isthmus. Cardiorespiratory motion induces position uncertainties resulting in decreased dose conformality. Electocardiograms (ECG) are typically used during cardiac MRI (CMR) to acquire images in a predefined cardiac phase, thus mitigating cardiac motion during image acquisition...
March 13, 2024: Medical Physics
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JOURNAL ARTICLE
Sara Latrofa, Valentina Hartwig, Lorenzo Bachi, Pasquale Notarstefano, Silvia Garibaldi, Luca Panchetti, Martina Nesti, Paolo Seghetti, Umberto Startari, Gianluca Mirizzi, Maria Sole Morelli, Martina Modena, Andrea Mazzanti, Michele Emdin, Alberto Giannoni, Andrea Rossi
INTRODUCTION: Repolarization dispersion in the right ventricular outflow tract (RVOT) contributes to the type-1 electrocardiographic (ECG) phenotype of Brugada syndrome (BrS), while data on the significance and feasibility of mapping repolarization dispersion in BrS patients are scarce. Moreover, the role of endocardial repolarization dispersion in BrS is poorly investigated. We aimed to assess endocardial repolarization patterns through an automated calculation of activation recovery interval (ARI) estimated on unipolar electrograms (UEGs) in spontaneous type-1 BrS patients and controls; we also investigated the relation between ARI and right ventricle activation time (RVAT), and T-wave peak-to-end interval (Tpe) in BrS patients...
March 13, 2024: Journal of Cardiovascular Electrophysiology
#15
JOURNAL ARTICLE
Alessandra Cipriano, Ram P Kapil, Mingyan Zhou, Manjunath S Shet, Garth T Whiteside, Sandra K Willsie, Stephen C Harris
Sunobinop is an investigational, potent, selective partial agonist at the nociceptin/orphanin FQ peptide receptor in vitro. Three phase 1 studies were conducted to evaluate the safety, tolerability, and pharmacokinetics (PK) of escalating single- and multiple-dose administration of sunobinop in healthy participants. Study 1 was a randomized, double-blind, placebo-controlled, single-ascending dose study. Study 2 was a randomized, double-blind, placebo-controlled, multiple-ascending dose study. Study 3 was a randomized, open-label, single-dose, 4-way crossover study of oral and sublingual sunobinop comparing morning (AM) and bedtime (PM) administration...
March 13, 2024: Clinical Pharmacology in Drug Development
#16
JOURNAL ARTICLE
Vasilis G Rodovitis, Eleni Verykouki, Kostas D Zarpas, Stella A Papanastasiou, Cleopatra A Moraiti, Nikos Patronis, Nikos T Papadopoulos
The Mediterranean fruit fly (medfly) (Ceratitis capitata, Diptera: Tephritidae), is an extremely polyphagous pest that threatens the fruit production and trading industry worldwide. Monitoring C. capitata populations and analysing its dynamics and phenology is considered of outmost importance for designing and implementing sound management approaches. The aim of this study was to investigate the factors regulating the population dynamics of the C. capitata in a coastal and semi-mountainous area. We focused on effects of topography (e...
March 12, 2024: Scientific Reports
#17
JOURNAL ARTICLE
Colby S Shemesh, Yongsheng Wang, Andrew An, Hao Ding, Phyllis Chan, Qi Liu, Yih-Wen Chen, Benjamin Wu, Qiong Wu, Xian Wang
PURPOSE: Tiragolumab is an immunoglobulin G1 monoclonal antibody targeting the immune checkpoint T cell immunoreceptor with immunoglobulin and immunoreceptor ITIM domains. Targeting multiple immune pathways may improve anti-tumor responses. The phase I YP42514 study assessed the pharmacokinetics (PK), safety, and preliminary efficacy of tiragolumab plus atezolizumab in Chinese patients with advanced solid tumors. METHODS: Adult patients from mainland China with Eastern Cooperative Oncology Group performance score 0/1, life expectancy of ≥ 12 weeks, and adequate hematologic/end organ function were eligible...
March 7, 2024: Cancer Chemotherapy and Pharmacology
#18
JOURNAL ARTICLE
Xue-Ming Li, Wei-Feng Yan, Ke Shi, Rui Shi, Li Jiang, Yue Gao, Chen-Yan Min, Xiao-Jing Liu, Ying-Kun Guo, Zhi-Gang Yang
BACKGROUND: Atrial fibrillation (AF) has been linked to an increased risk of cardiovascular death, overall mortality and heart failure in patients with type 2 diabetes mellitus (T2DM). The present study investigated the additive effects of paroxysmal AF on left ventricular (LV) function and deformation in T2DM patients with or without AF using the cardiovascular magnetic resonance feature tracking (CMR-FT) technique. METHODS: The present study encompassed 225 T2DM patients differentiated by the presence or absence of paroxysmal AF [T2DM(AF+) and T2DM(AF-), respectively], along with 75 age and sex matched controls, all of whom underwent CMR examination...
March 6, 2024: Cardiovascular Diabetology
#19
JOURNAL ARTICLE
Fouad A Alshaban, Iman Ghazal, Sanaa T Al-Harahsheh, Mustafa Lotfy, Hawraa Al-Shammari, Fatema Al-Faraj, I Richard Thompson, Allison B Ratto, Assal Nasir, Mohamed Tolefat
INTRODUCTION: The unprecedented impact of the coronavirus pandemic (COVID-19) has had profound implications on the ASD community, including disrupting daily life, increasing stress and emotional dysregulation in autistic children, and worsening individual and family well-being. METHODS: This study used quantitative and qualitative survey data from parents in Qatar (n=271), to understand the impact of the COVID-19 pandemic on autistic children and their families in Qatar...
2024: Frontiers in Psychiatry
#20
JOURNAL ARTICLE
Julieta Leone, Michael J Hassett, Rachel A Freedman, Sara M Tolaney, Noah Graham, Nabihah Tayob, Carlos T Vallejo, Eric P Winer, Nancy U Lin, José P Leone
IMPORTANCE: In women with hormone receptor-positive (HR+) breast cancer, the risk of distant recurrence and death persists for at least 20 years from diagnosis. The risk of late mortality in men with HR+ breast cancer has not been reported. OBJECTIVE: To report 20-year risks of breast cancer-specific mortality (BCSM) and non-BCSM in men with stage I to III HR+ breast cancer and identify factors associated with late BCSM. DESIGN, SETTING, AND PARTICIPANTS: An observational cohort study was conducted of men diagnosed with HR+ breast cancer from 1990 to 2008, using population-based data from the Surveillance, Epidemiology, and End Results program...
February 29, 2024: JAMA Oncology
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