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https://www.readbyqxmd.com/read/29671069/a-pharmacokinetics-and-pharmacodynamics-equivalence-trial-of-the-proposed-pegfilgrastim-biosimilar-myl-1401h-versus-reference-pegfilgrastim
#1
Cornelius F Waller, Renger G Tiessen, Tracey E Lawrence, Andrew Shaw, Mark Shiyao Liu, Rajiv Sharma, Mark Baczkowski, Mudgal A Kothekar, Catherine E Micales, Abhijit Barve, Gopinath M Ranganna, Eduardo J Pennella
PURPOSE: Pegfilgrastim is a long-acting granulocyte colony-stimulating factor indicated for prevention of febrile neutropenia in patients receiving myelosuppressive chemotherapy by promoting neutrophil recovery. METHODS: This phase 1, randomized, double-blind, three-way crossover trial in healthy volunteers evaluated the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of the proposed biosimilar, comparing MYL-1401H, reference pegfilgrastim (Neulasta® , Amgen Inc, Thousand Oaks, CA, USA) sourced from the European Union, and reference pegfilgrastim sourced from the USA...
April 18, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29655781/the-hyperopic-effect-of-narrow-band-long-wavelength-light-in-tree-shrews-increases-non-linearly-with-duration
#2
Alexander H Ward, Thomas T Norton, Carrie E Huisingh, Timothy J Gawne
During postnatal refractive development, an emmetropization mechanism uses refractive error to modulate the growth rate of the eye. Hyperopia (image focused behind the retina) produces what has been described as "GO" signaling that increases growth. Myopia (image focused in front of the retina) produces "STOP" signaling that slows growth. The interaction between GO and STOP conditions is non-linear; brief daily exposure to STOP counteracts long periods of GO. In young tree shrews, long-wavelength (red) light, presented 14 h per day, also appears to produce STOP signals...
April 12, 2018: Vision Research
https://www.readbyqxmd.com/read/29628575/hemodynamic-airway-pressure-and-capnometric-changes-and-perioperative-outcome-in-pediatric-laparoscopic-inguinal-herniorrhaphy-a-comparison-with-open-inguinal-herniorrhaphy
#3
Jyoti Garg, Suniti Kale, Nikki Sabharwal, Deepak Bagga, Anoop Raj Gogia
Background: Laparoscopic procedures which are now established in pediatric population as well exposes the child to supplemental cardiorespiratory changes due to increase in intraabdominal pressure (IAP) and hypercarbia. Aims: This study aims to analyze the effects of pneumoperitoneum and postural modifications on cardiorespiratory system (primary outcome) during pediatric laparoscopic herniorrhaphy (LH) and its comparison with open herniorrhaphy (OH) and assessment of overall perioperative outcome (secondary outcome)...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628573/does-restrictive-fluid-strategy-during-robotic-pelvic-surgeries-obtund-intraoperative-rise-in-intraocular-pressure
#4
Pulak Tosh, Saritha Valsala Krishnankutty, Sunil Rajan, Hema Muraleedharan Nair, Nitu Puthanveettil, Lakshmi Kumar
Background: Robotic pelvic surgeries require steep Trendelenburg position which may result in rise in intraocular pressure (IOP). Aim: The aim of this study was to compare the changes that occur in IOP during robotic pelvic surgeries in steep Trendelenburg position with a restrictive intravenous fluid administration. Settings and Design: This prospective observational study was conducted in a tertiary care institution. Subjects and Methods: Twenty consenting patients scheduled for pelvic robotic gynecological surgeries were enrolled...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29623136/the-effects-of-continuous-positive-airway-pressure-on-premature-ventricular-contractions-and-ventricular-wall-stress-in-patients-with-heart-failure-and-sleep-apnea
#5
Sabri Seyis, Adnan Kazım Usalan, Ibrahim Rencuzogullari, Özge Kurmuş, Adil Can Gungen
Background: We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure. Methods: Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29621201/remote-ischemic-preconditioning-does-not-affect-the-release-of-humoral-factors-in-propofol-anesthetized-cardiac-surgery-patients-a-secondary-analysis-of-the-ripheart-study
#6
Julia Ney, Katleen Hoffmann, Patrick Meybohm, Andreas Goetzenich, Sandra Kraemer, Carina Benstöm, Nina C Weber, Johannes Bickenbach, Rolf Rossaint, Gernot Marx, Kai Zacharowski, Jürgen Bernhagen, Christian Stoppe
In contrast to several smaller studies, which demonstrate that remote ischemic preconditioning (RIPC) reduces myocardial injury in patients that undergo cardiovascular surgery, the RIPHeart study failed to demonstrate beneficial effects of troponin release and clinical outcome in propofol-anesthetized cardiac surgery patients. Therefore, we addressed the potential biochemical mechanisms triggered by RIPC. This is a predefined prospective sub-analysis of the randomized and controlled RIPHeart study in cardiac surgery patients ( n = 40) that was recently published...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29593828/electrocardiogram-delineation-in-a-wistar-rat-experimental-model
#7
Pedro David Arini, Sergio Liberczuk, Javier Gustavo Mendieta, Martín Santa María, Guillermo Claudio Bertrán
Background and Objectives: The extensive use of electrocardiogram (ECG) recordings during experimental protocols using small rodents requires an automatic delineation technique in the ECG with high performance. It has been shown that the wavelet transform (WT) based ECG delineator is a suitable tool to delineate electrocardiographic waveforms. The aim of this work is to implement and evaluate the ECG waves delineation in Wistar rats applying WT. We also describe the ECG signal of the Wistar rats giving the characteristics of its spectrum among other useful information...
2018: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/29579014/a-physical-test-to-estimate-suitable-workloads-for-an-exercise-program-in-breast-cancer-survivors
#8
Elisabet Guillamó, Noemie Travier, Guillermo R Oviedo, Ana Fonseca-Nunes, Juan-Mariano Alamo, Francesc Cos, Ariadna Roca, Oscar Niño, Antonio Agudo, Casimiro Javierre
Epidemiologic studies suggest that patients with breast cancer who gain weight after diagnosis have a higher risk of recurrence and death. Regular physical exercise can help minimize post-diagnosis weight gain. The objective of the study was to assess the effectiveness of a physical test for individualizing the workloads used during a fitness program.To continuously individualize the intensity of the training, a test was designed and integrated into the sessions. The test consisted in monitoring heart rate and workload during two bouts of cycling at moderate intensity...
March 22, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29571290/exercise-capacity-in-diabetes-mellitus-is-predicted-by-activity-status-and-cardiac-size-rather-than-cardiac-function-a-case-control-study
#9
Timothy J Roberts, Andrew T Burns, Richard J MacIsaac, Andrew I MacIsaac, David L Prior, André La Gerche
BACKGROUND: The reasons for reduced exercise capacity in diabetes mellitus (DM) remains incompletely understood, although diastolic dysfunction and diabetic cardiomyopathy are often favored explanations. However, there is a paucity of literature detailing cardiac function and reserve during incremental exercise to evaluate its significance and contribution. We sought to determine associations between comprehensive measures of cardiac function during exercise and maximal oxygen consumption ([Formula: see text]peak), with the hypothesis that the reduction in exercise capacity and cardiac function would be associated with co-morbidities and sedentary behavior rather than diabetes itself...
March 23, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29554306/changes-in-hormone-profiles-growth-factors-and-mrna-expression-of-the-related-receptors-in-crop-tissue-relative-organ-weight-and-serum-biochemical-parameters-in-the-domestic-pigeon-columba-livia-during-incubation-and-chick-rearing-periods-under-artificial-farming
#10
P Xie, X P Wan, Z Bu, E J Diao, D Q Gong, X T Zou
The present study was conducted to determine the changes in concentrations of hormones and growth factors and their related receptor gene expressions in crop tissue, relative organ weight, and serum biochemical parameters in male and female pigeons during incubation and chick-rearing periods under artificial farming conditions. Seventy-eight pairs of 60-week-old White King pigeons with 2 fertile eggs per pair were randomly divided into 13 groups by different breeding stages. Serum prolactin and insulin-like growth factor-1 (IGF-1) concentrations in crop tissue homogenates were the highest in both male and female pigeons at 1 d of chick-rearing (R1), while epidermal growth factor (EGF) in female pigeons peaked at d 17 of incubation (I17) (P < 0...
March 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29552737/test-retest-reliability-of-internal-pudendal-artery-blood-flow-using-color-doppler-ultrasound-in-healthy-women
#11
Joanie Mercier, An Tang, Mélanie Morin, Marie-Claude Lemieux, Samir Khalifé, Barbara Reichetzer, Chantale Dumoulin
INTRODUCTION AND HYPOTHESIS: The internal pudendal artery (IPA) is one of the main arteries supplying the pelvic floor muscles (PFMs) and vulvo-vaginal tissues. Its assessment with color Doppler ultrasound has been documented previously, but the reliability of IPA measurements has never been assessed. This study evaluates the test-retest reliability of IPA blood flow parameters measured by color Doppler ultrasound under two conditions: at rest and after a PFM contraction task. METHODS: Twenty healthy women participated in this study...
March 19, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29550106/meta-analysis-of-t-peak-t-end-and-t-peak-t-end-qt-ratio-for-risk-stratification-in-congenital-long-qt-syndrome
#12
Gary Tse, Mengqi Gong, Lei Meng, Cheuk Wai Wong, Stamatis Georgopoulos, George Bazoukis, Martin C S Wong, Konstantinos P Letsas, Vassilios S Vassiliou, Yunlong Xia, Adrian M Baranchuk, Gan-Xin Yan, Tong Liu
BACKGROUND AND OBJECTIVES: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak -Tend interval and the Tpeak -Tend /QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpeak -Tend intervals and Tpeak -Tend /QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS...
March 6, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29505406/receiver-operating-characteristic-analysis-of-eigen-based-clutter-filters-for-ultrasound-color-flow-imaging
#13
Adrian J Y Chee, Alfred C H Yu
The eigen-based filter has theoretically established itself as a potent solution in ultrasound color flow imaging (CFI) for combating against clutter arising from moving tissues. Yet, it remains poorly understood on how much gain in flow detection sensitivity and specificity can be delivered by this adaptive clutter filter. Here, we investigated the receiver operating characteristic (ROC) of the eigen-based clutter filter to statistically evaluate its efficacy. Our investigation was conducted using a new vascular phantom testbed that incorporated both intrinsic tissue motion (vessel pulsation: 7...
March 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29500315/delivery-of-positive-end-expiratory-pressure-to-preterm-lambs-using-common-resuscitation-devices
#14
Marta Thio, Jennifer A Dawson, Kelly J Crossley, Timothy J Moss, Charles C Roehr, Graeme R Polglase, Peter G Davis, Stuart B Hooper
BACKGROUND: In neonatal resuscitation, a ventilation device providing positive end-expiratory pressure (PEEP) is recommended. There is limited information about PEEP delivery in vivo, using different models of self-inflating bag (SIB) at different inflation rates and PEEP settings. METHODS: We compared PEEP delivery to intubated preterm lambs using four commonly available models of paired SIBs and PEEP valves, with a T-piece, with gas flow of 8 L/min. Peak inspiratory pressure inflations of 30 cmH2 O, combined with set PEEP of 5, 7 and 10 cmH2 O, were delivered at rates of 20, 40 and 60/min...
March 2, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29497704/atypical-localization-and-dissociation-between-glucose-uptake-and-amyloid-deposition-in-cognitively-normal-apoe-e4-homozygotic-elders-compared-with-patients-with-late-onset-alzheimer-s-disease
#15
José V Pardo, Joel T Lee
Alzheimer's disease (AD) progresses insidiously over decades. Therefore, study of preclinical AD is critical to identify early pathophysiological changes as potential targets for prevention or treatment. The brain processes at the preclinical stage remain minimally understood. Aside from age, the E4 allele of APOE flags a group at particularly high risk of late-onset AD (LOAD). Studies of these individuals could provide insights about the ontogenesis of AD offering clues for novel treatment strategies. To this end, cognitively normal, APOE*E4 homozygotes from the Alzheimer's Diseases Neuroimaging Research Initiative database (ADNI-LONI) provided fluorodeoxyglucose and amyloid (florbetapir) PET scans ( n = 8 and 7, respectively; mean age 76 years)...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29481950/methylglyoxal-induced-glycation-and-aggregation-of-human-serum-albumin-biochemical-and-biophysical-approach
#16
Azaj Ahmed, Anas Shamsi, Mohd Shahnawaz Khan, Fohad Mabood Husain, Bilqees Bano
Serum protein glycation and formation of advanced glycation end products (AGEs) correlates with many diseases viz. diabetes signifying the importance of studying the glycation pattern of serum proteins. In our present study, methylglyoxal was investigated for its effect on the structure of human serum albumin (HSA); exploring the formation of AGEs and aggregates of HSA. The analytical tools employed includes intrinsic and extrinsic fluorescence, UV spectroscopy, far UV circular dichroism, Thioflavin T fluorescence, congo red binding, polyacrylamide gel electrophoresis (PAGE)...
February 23, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29477501/evaluation-of-ventricular-repolarization-features-with-tp-e-tp-e-qtc-jtc-and-jtd-during-electroconvulsive-therapy
#17
Fatma Yilmaz Coşkun, Gülçin Elboğa, Gökhan Altunbaş, Ertan Vuruşkan, Berna Kaya Uğur, Murat Sucu
OBJECTIVE: The purpose of this study was to investigate the influence of electrical stimulation transmitted through the body during electroconvulsive therapy on traditional and relatively new ventricular repolarization parameters (Rate corrected QT interval (QTc), QT dispersion (QTd), rate corrected JT interval (JTc), JT dispersion (JTd), T-peak to T-end interval (Tp-e) and Tp-e/QTc ratio) under propofol anaesthesia. METHODS: Twenty-two patients (aged 18-50 years) who were each scheduled for ECT for major depression, bipolar disorder or schizophrenia enrolled to the study...
February 12, 2018: Journal of Electrocardiology
https://www.readbyqxmd.com/read/29471032/results-of-an-asthma-education-program-delivered-via-telemedicine-in-rural-schools
#18
Tamara T Perry, Jill S Halterman, Rita H Brown, Chunqiao Luo, Shemeka M Randle, Cassandra R Hunter, Mallikarjuna Rettiganti
BACKGROUND: Asthma morbidity is high among low-income children living in rural U.S. regions, yet few interventions have been designed to reduce asthma burden among rural populations. OBJECTIVE: Examine the impact of a school-based asthma education program delivered via telemedicine among children living in an impoverished, rural region. METHODS: We conducted a cluster randomized trial with rural children, ages 7-14 years, comparing a school-based telemedicine asthma education intervention to usual care...
February 19, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29466049/use-of-pressure-mapping-for-quantitative-analysis-of-pressure-points-induced-by-external-coaptation-of-the-distal-portion-of-the-pelvic-limb-of-dogs
#19
Ashley E Iodence, Anastasia M Olsen, Kirk C McGilvray, Colleen G Duncan, Felix M Duerr
OBJECTIVE To quantitatively measure the amount of pressure induced at the calcaneus and cranial tibial surface of dogs by use of 2 cast configurations. ANIMALS 13 client- or student-owned dogs. PROCEDURES Pressure sensors were placed over the calcaneus and cranial tibial surface. Dogs then were fitted with a fiberglass cast on a pelvic limb extending from the digits to the stifle joint (tall cast). Pressure induced over the calcaneus and proximal edge of the cast at the level of the cranial tibial surface was simultaneously recorded during ambulation...
March 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29459176/variations-of-t-and-b-lymphocytes-of-flounder-paralichthys-olivaceus-after-hirame-novirhabdovirus-infection-and-immunization
#20
Jing Xing, Lei Wang, Mengxiao Zhen, Xiaoqian Tang, Wenbin Zhan
T and B lymphocytes are closely related to immunization and pathogen infection. Our previous study confirmed the CD3+ , CD4-1+ , CD4-2+ , CD8β+ T lymphocytes and IgM+ B lymphocytes presented in the peripheral blood leukocytes (PBLs) of flounder (Paralichthys olivaceus), in this paper, the variations of T and B lymphocytes of flounder after Hirame novirhabdovirus (HIRRV) infection or immunization were investigated. The flounders were injected with live or inactivated HIRRV, then the percentages of T and B lymphocytes in PBLs were analyzed by Flow cytometry (FCM), total antibodies and HIRRV-specific antibodies in serum were detected by Enzyme-linked immunosorbent assay (ELISA), and expression of twelve immune-related genes in the head kidneys were determined using q-PCR...
February 16, 2018: Molecular Immunology
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