keyword
MENU ▼
Read by QxMD icon Read
search

t peak to t end

keyword
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#1
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29422642/in-silico-non-homologous-end-joining-following-ion-induced-dna-double-strand-breaks-predicts-that-repair-fidelity-depends-on-break-density
#2
N T Henthorn, J W Warmenhoven, M Sotiropoulos, R I Mackay, N F Kirkby, K J Kirkby, M J Merchant
This work uses Monte Carlo simulations to investigate the dependence of residual and misrepaired double strand breaks (DSBs) at 24 hours on the initial damage pattern created during ion therapy. We present results from a nanometric DNA damage simulation coupled to a mechanistic model of Non-Homologous End Joining, capable of predicting the position, complexity, and repair of DSBs. The initial damage pattern is scored by calculating the average number of DSBs within 70 nm from every DSB. We show that this local DSB density, referred to as the cluster density, can linearly predict misrepair regardless of ion species...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29402724/effects-of-acute-or-chronic-heat-exposure-exercise-and-dehydration-on-plasma-cortisol-il-6-and-crp-levels-in-trained-males
#3
Joseph T Costello, Rebecca A Rendell, Matthew Furber, Heather C Massey, Michael J Tipton, John S Young, Jo Corbett
This study examined the acute and chronic effects of euhydrated and hypohydrated heat exposure, on biomarkers of stress and inflammation. Eight trained males [mean (SD) age: 21 (3) y; mass: 77.30 (4.88) kg; V̇O2max: 56.9 (7.2) mL kg-1 min-1] undertook two heat acclimation programmes (balanced cross-over design), once drinking to maintain euhydration and once with restricted fluid-intake (permissive dehydration). Days 1, 6, and 11 were 60 min euhydrated exercise-heat stress tests (40 °C; 50% RH, 35% peak power output), days 2-5 and 7-10 were 90 min, isothermal-strain (target rectal temperature: 38...
February 2, 2018: Cytokine
https://www.readbyqxmd.com/read/29402358/-effect-of-early-mobilization-on-diaphragmatic-function-in-patients-with-mechanical-ventilation-a-prospective-randomized-controlled-study
#4
Shengqiang Yang, Jinggang Liu, Wenbao Yang, Jiyin Yuan, Suqiu Meng, Maoling Liang, Qibiao Shi
OBJECTIVE: To investigate the effect of early mobilization on diaphragmatic function in patients with mechanical ventilation (MV). METHODS: Sixty chronic obstructive pulmonary disease with acute exacerbation (AECOPD) patients with respiratory failure (RF) and underwent MV admitted to intensive care unit (ICU) of Huxi Affiliated Hospital of Jining Medical College from January 2016 to January 2017 were enrolled. The patients were divided into treatment group (n = 30) and control group (n = 30) by randomly number table method...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29399929/electrocardiographic-parameters-effectively-predict-ventricular-tachycardia-fibrillation-in-acute-phase-and-abnormal-cardiac-function-in-chronic-phase-of-st-segment-elevation-myocardial-infarction
#5
Ziqing Yu, Zhangwei Chen, Yuan Wu, Ruizhen Chen, Minghui Li, Xueying Chen, Shengmei Qin, Yixiu Liang, Yangang Su, Junbo Ge
BACKGROUND: Abnormal cardiac repolarization is closely associated with ventricular tachycardia/ventricular fibrillation (VT/VF). Myocardial ischemia and infarction aggravate cardiac repolarization dispersion, and VT/VF could be lethal in the early stage of ST-segment elevation myocardial infarction (STEMI). Unfortunately, VT/VF cannot be effectively predicted in current clinical practice. The present study aimed to assess electrocardiographic parameters of the sinus rhythmic complex in relation to cardiac repolarization, e...
February 5, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29396605/composting-of-sewage-sludge-with-a-simple-aeration-method-and-its-utilization-as-a-soil-fertilizer
#6
Thanh-Binh Nguyen, Kazuto Shima
The objective of this study was to examine the feasibility of sewage sludge composting using a simple aeration method. Two consecutive composting trials (run A and run B) using Japanese sludge and woodchips (1:1, v/v) were conducted in cubic boxes (0.45 × 0.45 × 0.45 m3) made by plywood at Okayama University. Air was forced up through small holes perforated on two open-ended parallel PVC pipes (ø 16 mm, 0.25 m apart) laid at the base. The results show that compost temperatures were rapidly increased to the peak points of 47...
February 2, 2018: Environmental Management
https://www.readbyqxmd.com/read/29393744/lack-of-effectiveness-of-tramadol-hydrochloride-for-the-treatment-of-pain-and-joint-dysfunction-in-dogs-with-chronic-osteoarthritis
#7
Steven C Budsberg, Bryan T Torres, Stephanie A Kleine, Gabriella S Sandberg, Amanda K Berjeski
OBJECTIVE To investigate the effectiveness of tramadol for treatment of osteoarthritis in dogs. DESIGN Randomized, blinded, placebo-controlled crossover study. ANIMALS 40 dogs with clinical osteoarthritis of the elbow or stifle joint. PROCEDURES Dogs orally received 3 times/d (morning, midday, and night) for a 10-day period each of 3 identically appearing treatments (placebo; carprofen at 2.2 mg/kg [1 mg/lb], q 12 h [morning and night], with placebo at midday; or tramadol hydrochloride at 5 mg/kg [2.3 mg/lb], q 8 h) in random order, with treatment sessions separated by a minimum 7-day washout period...
February 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29382211/depression-associated-with-transitions-into-and-out-of-spousal-caregiving
#8
Jennifer E Kaufman, Yeonjung Lee, Wendy Vaughon, Aig Unuigbe, William T Gallo
This study investigates depressive symptoms among spousal caregivers in three groups: those who become caregivers, those who continue care, and those who exit caregiving, compared with those who remain non-caregivers. We also examine depressive symptoms among widowed caregivers by length of bereavement. We use four waves of the U.S. Health and Retirement Study (2006, 2008, 2010, and 2012), for a total of 43,262 observations. Findings show elevated levels of depressive symptoms for new caregivers, continuing caregivers, and exit caregivers...
January 1, 2018: International Journal of Aging & Human Development
https://www.readbyqxmd.com/read/29369370/evaluation-of-qt-dispersion-and-tp-e-interval-in-children-with-subclinical-hypothyroidism
#9
Alper Akın, Edip Unal, Ruken Yıldırım, Mehmet Türe, Hasan Balık, Yusuf Kenan Haspolat
BACKGROUND: Studies on adults, have shown increased dispersion of QT and corrected QT (cQT), peak-to-end interval of the T wave (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio in subclinical hypothyroidism (SH), but there have been no paediatric studies MATERIALS AND METHODS: A total of 40 SH patients were compared with 40 healthy children in respect of serum thyroid stimulating hormone (TSH), serum free level of triiodothyronine (fT3) and free level of thyroxine (fT4). SH diagnosis was accepted as TSH above the laboratory accepted upper limit (> 4...
January 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29361256/the-effect-of-sevoflurane-on-the-transmural-dispersion-of-repolarisation-in-patients-with-type-2-diabetes-mellitus-a-prospective-observational-study
#10
V Thiruvenkatarajan, J Jeyadoss, V Rao Kadam, L Y Du, W-M Liu, R M Van Wijk
The 'torsadogenic' property of a drug is linked to its ability to increase the transmural dispersion of repolarisation, represented by the interval between the peak of, and the end of, the T-wave (Tp-e interval) in an electrocardiogram. Reports have consistently shown that sevoflurane does not increase the Tp-e interval. Type 2 diabetes is a risk factor for increased QTc (rate-corrected QT interval), QTcd (rate-corrected QTc dispersion: difference between the maximum and the minimum QTc interval), and Tp-e, as well as the rate-corrected Tp-e (Tp-e/QTc ratio)...
January 2018: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/29339700/assessment-of-the-relationship-between-reperfusion-success-and-t-peak-to-t-end-interval-in-patients-with-st-elevation-myocardial-infarction-treated-with-percutaneous-coronary-intervention
#11
Metin Çağdaş, Süleyman Karakoyun, İbrahim Rencüzoğulları, Yavuz Karabağ, Mahmut Yesin, Yalçın Velibey, İnanç Artaç, Doğan İliş, Süleyman Çağan Efe, Onur Taşar, Halil İbrahim Tanboğa
OBJECTIVE: T-peak-T-end (TPE) interval, which represents the dispersion of repolarization, is defined as the interval between the peak and end of the T-wave, and is associated with increased malignant ventricular arrhythmia and sudden cardiac death (SCD) in patients with ST elevation myocardial infarction (STEMI). Although prolonged TPE interval is associated with poor short- and long-term outcomes, even in patients with STEMI treated with successful primary percutaneous coronary intervention (pPCI), clinical, angiographic, and laboratory parameters that affect TPE remain to be elucidated...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29301798/enhanced-elimination-of-cyclophosphamide-by-high-cut-off-haemodialysis-single-dose-pharmacokinetics-in-a-patient-with-cast-nephropathy
#12
Gabriele Eden, W Nikolaus Kühn-Velten, Carsten Hafer, Jan T Kielstein
High cut-off (HCO) haemodialysis removes free light chains in patients with multiple myeloma. This is possible as HCO dialysers allow clearance of molecules up to a molecular weight of 65 kDa. In contrast, high-flux dialysers, which are used in routine haemodialysis, only remove molecules up to a molecular weight of 20 kDa. Even though patients with advanced myeloma frequently need dialysis and alkylating agents, drug dosing recommendations in this patient population are scarce at best or absent as for cyclophosphamide dosing in patients with myeloma undergoing HCO dialysis...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29298692/an-in-vivo-comparison-of-stimulated-echo-and-motion-compensated-spin-echo-sequences-for-3%C3%A2-t-diffusion-tensor-cardiovascular-magnetic-resonance-at-multiple-cardiac-phases
#13
Andrew D Scott, Sonia Nielles-Vallespin, Pedro F Ferreira, Zohya Khalique, Peter D Gatehouse, Philip Kilner, Dudley J Pennell, David N Firmin
BACKGROUND: Stimulated-echo (STEAM) and, more recently, motion-compensated spin-echo (M2-SE) techniques have been used for in-vivo diffusion tensor cardiovascular magnetic resonance (DT-CMR) assessment of cardiac microstructure. The two techniques differ in the length scales of diffusion interrogated, their signal-to-noise ratio efficiency and sensitivity to both motion and strain. Previous comparisons of the techniques have used high performance gradients at 1.5 T in a single cardiac phase...
January 3, 2018: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/29258502/impaired-ventricular-filling-limits-cardiac-reserve-during-submaximal-exercise-in-people-with-type-2-diabetes
#14
Genevieve A Wilson, Gerard T Wilkins, Jim D Cotter, Regis R Lamberts, Sudish Lal, James C Baldi
BACKGROUND: Attenuated increases in ventricular stroke volume during exercise are common in type 2 diabetes and contribute to reduced aerobic capacity. The purpose of this study was to determine whether impaired ventricular filling or reduced systolic ejection were responsible for the attenuated stroke volume reserve in people with uncomplicated type 2 diabetes. METHODS: Peak aerobic capacity and total blood volume were measured in 17 people with diabetes and 16 non-diabetic controls with no evidence of cardiovascular disease...
December 19, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29251645/dopamine-d2-receptor-antagonist-droperidol-deepens-sevoflurane-anesthesia
#15
Ryuhei Araki, Kazuko Hayashi, Teiji Sawa
BACKGROUND: Although midbrain dopaminergic pathways are known to contribute to arousal and emergence from anesthesia, few reports exist regarding the anesthetic effects of dopamine D2 receptor antagonism in humans. This study examined the effect of the D2 receptor antagonist droperidol on sevoflurane anesthesia by examining α and slow wave electroencephalogram oscillations. METHODS: Forty-five patients, age 20 to 60 yr, were enrolled. Frontal electroencephalograms were continuously collected for offline analysis via Bispectral Index monitoring...
December 15, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29230860/cardiac-gating-using-scattering-of-an-8-channel-parallel-transmit-coil-at-7t
#16
Sven H F Jaeschke, Matthew D Robson, Aaron T Hess
PURPOSE: To establish a cardiac signal from scattering matrix or scattering coefficient measurements made on a 7T 8-channel parallel transmit (pTx) system, and to evaluate its use for cardiac gating. METHODS: Measurements of the scattering matrix and scattering coefficients were acquired using a monitoring pulse sequence and during a standard cine acquisition, respectively. Postprocessing used an independent component analysis and gating feature identification. The effect of the phase of the excitation radiofrequency (RF) field ( B1+ shim) on the cardiac signal was simulated for multiple B1+ shim configurations, and cine images were reconstructed from both the scattering coefficients and electrocardiogram (ECG)...
December 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29227281/targeting-mcl-1-enhances-dna-replication-stress-sensitivity-to-cancer-therapy
#17
Guo Chen, Andrew T Magis, Ke Xu, Dongkyoo Park, David S Yu, Taofeek K Owonikoko, Gabriel L Sica, Sarah W Satola, Suresh S Ramalingam, Walter J Curran, Paul W Doetsch, Xingming Deng
DNA double-strand breaks (DSBs) are mainly repaired either by homologous recombination (HR) or by nonhomologous end-joining (NHEJ) pathways. Here, we showed that myeloid cell leukemia sequence 1 (Mcl-1) acts as a functional switch in selecting between HR and NHEJ pathways. Mcl-1 was cell cycle-regulated during HR, with its expression peaking in S/G2 phase. While endogenous Mcl-1 depletion reduced HR and enhanced NHEJ, Mcl-1 overexpression resulted in a net increase in HR over NHEJ. Mcl-1 directly interacted with the dimeric Ku protein complex via its Bcl-2 homology 1 and 3 (BH1 and BH3) domains, which are required for Mcl-1 to inhibit Ku-mediated NHEJ...
December 11, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29225104/evaluation-of-qt-dispersion-and-t-peak-to-t-end-interval-in-patients-with-early-stage-sarcoidosis
#18
Hacı Ahmet Kasapkara, Ayşegül Şentürk, Emine Bilen, Hüseyin Ayhan, Bilge Duran Karaduman, Zeynep Şeyma Turinay, Murat Can Güney, Tahir Durmaz, Telat Keleş, Engin Bozkurt
INTRODUCTION AND AIM: Sarcoidosis increases inhomogeneity in ventricular repolarization due to the presence of sarcoid granuloma, which significantly correlates with ventricular fibrillation. Various studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (T-peak to T-end [Tpe] interval) may correspond to the transmural dispersion of repolarization and that increased Tpe interval and Tpe/QT ratio are associated with malignant ventricular arrhythmias...
December 7, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29220728/assessment-of-long-term-exposure-to-airborne-dioxin-and-cadmium-concentrations-in-the-lyon-metropolitan-area-france
#19
T Coudon, H Hourani, C Nguyen, E Faure, F R Mancini, B Fervers, P Salizzoni
Identifying the long-term effects of airborne pollutants requires the computation of the spatial and temporal variability of their concentration in air to estimate the exposure of the population. To estimate exposure levels of individuals in a breast cancer case control study nested in a national prospective cohort, we determine here the differential impact of a variety of cadmium and dioxin sources on urban air over a large urban area and over a period of almost 20years. To that end, we couple an emission model, to estimate dioxin and cadmium atmospheric annual releases, with an urban dispersion model in order to compute pollutant concentration fields at a fine temporal (1h) and spatial (25m) resolution...
December 5, 2017: Environment International
https://www.readbyqxmd.com/read/29214506/pharmacokinetics-of-oral-and-intravenous-paracetamol-acetaminophen-when-co-administered-with-intravenous-morphine-in-healthy-adult-subjects
#20
Robert B Raffa, Jayne Pawasauskas, Joseph V Pergolizzi, Luke Lu, Yin Chen, Sutan Wu, Brant Jarrett, Randi Fain, Lawrence Hill, Krishna Devarakonda
BACKGROUND AND OBJECTIVE: Several features favor paracetamol (acetaminophen) administration by the intravenous rather than the oral route in the postoperative setting. This study compared the pharmacokinetics and bioavailability of oral and intravenous paracetamol when given with or without an opioid, morphine. METHODS: In this randomized, single-blind, parallel, repeat-dose study in healthy adults, subjects received four repeat doses of oral or intravenous 1000 mg paracetamol at 6-h intervals, and morphine infusions (0...
December 6, 2017: Clinical Drug Investigation
keyword
keyword
119204
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"