Elsa Zacco, Laura Broglia, Misuzu Kurihara, Michele Monti, Stefano Gustincich, Annalisa Pastore, Kathrin Plath, Shinichi Nagakawa, Andrea Cerase, Natalia Sanchez de Groot, Gian Gaetano Tartaglia
This comprehensive Review delves into the chemical principles governing RNA-mediated crowding events, commonly referred to as granules or biological condensates. We explore the pivotal role played by RNA sequence, structure, and chemical modifications in these processes, uncovering their correlation with crowding phenomena under physiological conditions. Additionally, we investigate instances where crowding deviates from its intended function, leading to pathological consequences. By deepening our understanding of the delicate balance that governs molecular crowding driven by RNA and its implications for cellular homeostasis, we aim to shed light on this intriguing area of research...
April 5, 2024: Chemical Reviews