Guilherme Grossi Lopes Cançado, Nathalia Mota de Faria Gomes, Cláudia Alves Couto, Eduardo Luiz Rachid Cançado, Debora Raquel Benedita Terrabuio, Cristiane Alves Villela-Nogueira, Michelle Harriz Braga, Mateus Jorge Nardelli, Luciana Costa Faria, Elze Maria Gomes Oliveira, Vivian Rotman, Maria Beatriz Oliveira, Simone Muniz Carvalho Fernandes da Cunha, Daniel Ferraz de Campos Mazo, Liliana Sampaio Costa Mendes, Claudia Alexandra Pontes Ivantes, Liana Codes, Valéria Ferreira de Almeida E Borges, Fabio Heleno de Lima Pace, Mário Guimarães Pessôa, Izabelle Venturini Signorelli, Gabriela Perdomo Coral, Paulo Lisboa Bittencourt, Patrícia Fucuta, Roberto José de Carvalho Filho, Maria Lucia Gomes Ferraz
BACKGROUND: Ursodeoxycholic acid (UDCA) is the standard treatment for primary biliary cholangitis (PBC), but a significant proportion of patients do not respond adequately, leading to increased risk of adverse outcomes. This study aims to develop a new and straightforward predictive score to identify PBC patients likely to achieve a complete response to UDCA. METHODS: A logistic regression analysis was conducted using a derivation cohort of PBC patients to identify pre-treatment variables associated with response to UDCA...
May 1, 2024: European Journal of Gastroenterology & Hepatology