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https://www.readbyqxmd.com/read/27933614/antiviral-agents-for-infectious-mononucleosis-glandular-fever
#1
REVIEW
Muireann De Paor, Kirsty O'Brien, Tom Fahey, Susan M Smith
BACKGROUND: Infectious mononucleosis (IM) is a clinical syndrome, usually caused by the Epstein Barr virus (EPV), characterised by lymphadenopathy, fever and sore throat. Most cases of symptomatic IM occur in older teenagers or young adults. Usually IM is a benign self-limiting illness and requires only symptomatic treatment. However, occasionally the disease course can be complicated or prolonged and lead to decreased productivity in terms of school or work. Antiviral medications have been used to treat IM, but the use of antivirals for IM is controversial...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933135/impact-of-laparoscopic-surgery-training-laboratory-on-surgeon-s-performance
#2
REVIEW
Fabio C M Torricelli, Joao Arthur B A Barbosa, Giovanni S Marchini
Minimally invasive surgery has been replacing the open standard technique in several procedures. Similar or even better postoperative outcomes have been described in laparoscopic or robot-assisted procedures when compared to open surgery. Moreover, minimally invasive surgery has been providing less postoperative pain, shorter hospitalization, and thus a faster return to daily activities. However, the learning curve required to obtain laparoscopic expertise has been a barrier in laparoscopic spreading. Laparoscopic surgery training laboratory has been developed to aid surgeons to overcome the challenging learning curve...
November 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27930596/systemic-inflammatory-response-syndrome-is-more-associated-with-bacteremia-in-elderly-patients-with-suspected-sepsis-in-emergency-departments
#3
Hsien-Ling Chou, Shih-Tsung Han, Chun-Fu Yeh, I-Shaing Tzeng, Tsung-Han Hsieh, Chin-Chieh Wu, Jen-Tse Kuan, Kuan-Fu Chen
Early diagnosis of bacteremia for patients with suspected sepsis is 1 way to improve prognosis of sepsis. Systemic inflammatory response syndrome (SIRS) has long been utilized as a screening tool to detect bacteremia by front-line healthcare providers. The value of SIRS to predict bacteremia in elderly patients (≥65 years) with suspected sepsis has not yet been examined in emergency departments (EDs).We aimed to evaluate the performance of SIRS components in predicting bacteremia among elderly patients in EDs...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929925/evaluation-of-factors-associated-with-death-in-patients-with-necrotizing-fasciitis-of-the-abdominal-wall
#4
Christian W Ertl, Nicole C Carpp, Jeffrey Johnson, Leandra Burke
BACKGROUND: Necrotizing fasciitis (NF) is a rapidly progressing, life-threatening soft tissue infection. The prognostic factors associated with death from abdominal wall NF are not well understood. METHODS: The medical records of 61 patients with abdominal wall NF were reviewed retrospectively. Demographic, co-morbidity, laboratory, and clinical data were collected and compared for patients who survived and who did not. RESULTS: Sixty-one patients met the inclusion criteria, with eight deaths (13...
December 8, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27929354/differences-in-mrsa-prevalence-and-resistance-patterns-in-a-tertiary-center-before-and-after-joining-an-international-program-for-surveillance-of-antimicrobial-resistance
#5
Olivera Djuric, Snezana Jovanovic, Branka Stosovic, Tanja Tosic, Milica Jovanovic, Naomi Nartey, Jovana Todorovic, Ljiljana Markovic-Denic
Methicillin-resistant Staphylococcus aureus (MRSA) emerged as one of the most important causes of hospital-acquired bloodstream infections (BSIs), especially the multidrug resistant clones. The aim of the present study was to compare prevalence and resistance patterns of MRSA bacteremia in the major tertiary-care academic and referral center in Serbia before and after implementing an active antimicrobial resistance (AMR) surveillance. Laboratory-based before-after study was conducted during a two-year period (January 2012 to December 2013) in Clinical Centre of Serbia...
December 8, 2016: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/27928226/achieving-timely-percutaneous-reperfusion-for-rural-st-elevation-myocardial-infarction-patients-by-direct-transport-to-an-urban-pci-hospital
#6
Charles-Lwanga K Bennin, Saif Ibrahim, Farah Al-Saffar, Lyndon C Box, Joel A Strom
BACKGROUNDS: ST-elevation myocardial infarction (STEMI) guidelines recommend reperfusion by primary percutaneous coronary intervention (PCI) ≤ 90 min from time of first medical contact (FMC). This strategy is challenging in rural areas lacking a nearby PCI-capable hospital. Recommended reperfusion times can be achieved for STEMI patients presenting in rural areas without a nearby PCI-capable hospital by ground transportation to a central PCI-capable hospital by use of protocol-driven emergency medical service (EMS) STEMI field triage protocol...
October 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27928148/acute-transverse-myelitis-associated-with-salmonella-bacteremia-a-case-report
#7
Mary E Richert, Hillary Hosier, Adam S Weltz, Eric S Wise, Manjari Joshi, Jose J Diaz
BACKGROUND Acute transverse myelitis (ATM) is an uncommon and often overlooked complication of certain bacterial and viral infections that can have a rapid onset and result in severe neurological deficits.  CASE REPORT This case report describes a previously healthy 28-year-old woman who presented to the trauma center after developing acute paralysis and paresthesias of all four extremities within the span of hours. The initial presumptive diagnosis was spinal cord contusion due to a fall versus an unknown mechanism of trauma, but eventual laboratory studies revealed Salmonella bacteremia, indicating a probable diagnosis of parainfectious ATM...
December 8, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27927926/clinical-and-microbiological-aspects-of-%C3%AE-lactam-resistance-in-staphylococcus-lugdunensis
#8
Ian H McHardy, Jennifer Veltman, Janet Hindler, Katia Bruxvoort, Marissa M Carvalho, Romney M Humphries
Antimicrobial susceptibility results from broth microdilution MIC testing of 993 S. lugdunensis isolates recovered from patients at a tertiary care medical center from 2008-2015 were reviewed. Ninety-two oxacillin-susceptible isolates were selected to assess the accuracy of penicillin MIC, penicillin disk diffusion and three β-lactamase tests, including the cefoxitin-induced nitrocefin test, penicillin cloverleaf assay and penicillin disk zone-edge test. Results of all phenotypic tests were compared to blaZ PCR...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927923/biofeature-lynne-s-garcia-m-s-f-aam
#9
Betty A Forbes
Comments provided by Mike Saubolle, Medical Director, Infectious Diseases Division, Laboratory Sciences of Arizona and Clinical Associate Professor at the University of Arizona College of Medicine in Tuscon set the stage for Lynne S Garcia's, M.S., F(AAM) biofeature and capture the spirit of Lynne ….
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927920/validation-of-autoclave-protocols-for-the-successful-decontamination-of-category-a-medical-waste-generated-from-the-care-of-patients-with-serious-communicable-diseases
#10
Brian T Garibaldi, Mallory Reimers, Neysa Ernst, Gregory Bova, Elaine Nowakowski, James Bukowski, Brandon C Ellis, Chris Smith, Lauren Sauer, Kim Dionne, Karen C Carroll, Lisa L Maragakis, Nicole M Parrish
In response to the Ebola outbreak in 2014, many hospitals designated specific areas to care for patients with Ebola and other highly infectious diseases. The safe handling of Category A infectious substances is a unique challenge in this environment. One solution is onsite waste treatment with a steam sterilizer or autoclave. The Johns Hopkins Hospital (JHH) installed two pass-through autoclaves in its Biocontainment Unit (BCU). The JHH BCU and The Johns Hopkins Biosafety Level 3 Clinical Microbiology Laboratory designed and validated waste handling protocols with simulated patient trash to ensure adequate sterilization...
December 7, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27927872/mumps-outbreak-among-a-highly-vaccinated-university-community-new-york-city-ny-january-april-2014
#11
Leena N Patel, Robert Arciuolo, Jie Fu, Francesca R Giancotti, Jane R Zucker, Jennifer Rakeman, Jennifer B Rosen
BACKGROUND: On January 14, 2014, a vaccinated student presented with parotitis. Mumps IgM testing was negative and reverse-transcription polymerase chain reaction (RT-PCR) testing was not performed, resulting in a missed diagnosis and the start of an outbreak at a New York City (NYC) university. METHODS: Mumps case investigations included patient interviews, medical records review, and laboratory testing including mumps serology and RT-PCR. Cases were considered linked to the outbreak if they attended or had epidemiologic linkage to the university...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27927843/risk-of-childhood-mortality-in-family-members-of-men-with-poor-semen-quality
#12
Heidi A Hanson, Erik N Mayer, Ross E Anderson, Kenneth I Aston, Douglas T Carrell, Justin Berger, William T Lowrance, Ken R Smith, James M Hotaling
STUDY QUESTION: What is the familial childhood mortality in first-degree (FDR) and second-degree relatives (SDR) of patients undergoing semen analysis (SA)? SUMMARY ANSWER: The relationship between infertility and congenital malformations (CM) in offspring is complex, with an increased risk of death due to CM in FDR, but not SDR, of men with lower semen parameters. WHAT IS KNOWN ALREADY: Semen quality is an established predictor of men's somatic health...
December 6, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27927710/adrenocortical-carcinoma-an-unusual-cause-of-secondary-hypertension
#13
Daniel Veron Esquivel, Fernando Batiz, Alfonso Farias Vega, Perla A Carrillo Gonzalez
We present the case of a female patient aged 39 years who was admitted to our hospital due to hypertension, severe hypokalaemia and metabolic alkalosis; physical examination was remarkable for plethoric moon face, centripetal obesity and bilateral lower extremity oedema. She was admitted for intravenous potassium replacement and further assessment of hypertension and associated clinical findings. Laboratory testing showed increased levels of aldosterone, renin, cortisol, testosterone and androstenedione. An abdominal CT revealed a large mass in the right adrenal gland with hepatic involvement...
December 7, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27927187/the-importance-of-proteinuria-and-prior-cardiovascular-disease-in-all-major-clinical-outcomes-of-atherosclerotic-renovascular-disease-a-single-center-observational-study
#14
Diana Vassallo, James Ritchie, Darren Green, Constantina Chrysochou, Joseph Blunt, Philip A Kalra
BACKGROUND: Identification of patients at risk of developing adverse events would enable aggressive medical therapy and possibly targeted revascularization. The aim of this study is to characterize the determinants of long-term outcomes in atherosclerotic renovascular disease (ARVD). METHODS: Patients with a radiological diagnosis of ARVD were recruited into this single-center prospective cohort study between 1986 and 2014. Data collected included baseline co-morbid conditions, annualized prescribed medications and laboratory data (serum creatinine [υmol/L], proteinuria [g/24 h])...
December 7, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27926663/the-impact-of-value-based-healthcare-for-inflammatory-bowel-diseases-on-healthcare-utilization-a-pilot-study
#15
Welmoed K van Deen, Arlen Spiro, A Burak Ozbay, Martha Skup, Adriana Centeno, Natalie E Duran, Precious N Lacey, Darius Jatulis, Eric Esrailian, Martijn G H van Oijen, Daniel W Hommes
BACKGROUND AND OBJECTIVES: Value-based healthcare (VBHC) is considered to be the solution that will improve quality and decrease costs in healthcare. Many hospitals are implementing programs on the basis of this strategy, but rigorous scientific reports are still lacking. In this pilot study, we present the first-year outcomes of a VBHC program for inflammatory bowel disease (IBD) management that focuses on highly coordinated care, task differentiation of providers, and continuous home monitoring...
December 6, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27926449/the-role-of-dopamine-in-the-pathophysiology-and-treatment-of-apathy
#16
T T-J Chong, M Husain
Disorders of diminished motivation, such as apathy, are common and prevalent across a wide range of medical conditions, including Parkinson's disease, Alzheimer's dementia, stroke, depression, and schizophrenia. Such disorders have a significant impact on morbidity and quality of life, yet their management lacks consensus and remains unsatisfactory. Here, we review laboratory and clinical evidence for the use of dopaminergic therapies in the treatment of apathy. Dopamine is a key neurotransmitter that regulates motivated decision making in humans and other species...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27925380/angiotensin-converting-enzyme-2-polymorphisms-and-postexercise-hypotension-in-hypertensive-medicated-individuals
#17
Karla F Goessler, Marcos D Polito, Gloria de F Mota, Edilamar M de Oliveira, Véronique A Cornelissen
The renin-angiotensin aldosterone system (RAAS) is associated with diverse physiological responses and adaptations to exercise. The angiotensin converting enzyme (ACE) 2 has vasodilatory effects, which might be associated with the blood pressure (BP) responses to acute exercise. The aim of this study was to investigate the role of ACE2 polymorphisms in postexercise hypotension (PEH). Thirty-four medicated hypertensive (61·3 ± 1·7 years, 76·1 ± 2·7 kg, 160 ± 1·6 cm) men (n = 12) and women (n = 22), participated in a control and a moderate intensity exercise session in a randomized order...
December 7, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27925129/-public-sector-participation-in-the-supply-of-dyslipidemia-medication-in-a-population-based-study
#18
Airton José Petris, Regina Kazue Tanno de Souza, Maira Sayuri Sakay Bortoletto
The use of medications for the treatment of dyslipidemia is relevant in the control of cardiovascular disease. This article aims to analyze the prevalence, the use and the participation of the public sector in the supply of medication for adults aged 40 years and above using pharmacotherapy for dyslipidemia control living in a city in the southern region of Brazil. A cross-sectional, population-based study was conducted. Household interviews were staged with 1180 individuals aged over 40 living in Cambé, State of Paraná, of which 967 took laboratory examinations...
December 2016: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/27924638/understanding-sarcomas-and-other-rare-tumors-an-interview-with-robin-l-jones
#19
Robin L Jones
Robin Jones speaks to Jade Parker, Commissioning Editor: Robin Jones is a medical oncologist specializing in the treatment of bone and soft tissue sarcomas and Head of the Sarcoma Unit at The Royal Marsden. He completed his medical training at Guy's and St Thomas' Hospital, and his oncology training at The Royal Marsden. His postgraduate research degree, with Professor Dowsett at the Institute of Cancer Research (ICR), evaluated potential predictive and prognostic factors in breast cancer patients treated with neoadjuvant chemotherapy...
December 7, 2016: Future Oncology
https://www.readbyqxmd.com/read/27924218/sex-related-differences-in-the-associations-between-plasma-free-fatty-acid-levels-and-clinical-features-in-patients-with-hypertrophic-cardiomyopathy
#20
Chengzhi Yang, Changlin Zhang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Xuanye Bi, Shubin Qiao
BACKGROUND: Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid (FFA), a main energy substrate of heart, has an effect on HCM remains unclear. Besides, several studies have suggested sex-related differences in HCM features and FFA metabolism. Here, we aimed to explore the association between plasma FFA levels and HCM and potential effects of sex on this relation. METHODS: A total of 412 patients (age 47...
2016: Biology of Sex Differences
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