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https://www.readbyqxmd.com/read/28719224/cardiometabolic-risk-factors-and-health-related-quality-of-life-in-adolescents-with-obesity
#1
Anna Pogodina, Ljubov Rychkova, Olga Kravtzova, Juliana Klimkina, Arjuna Kosovtzeva
BACKGROUND: A number of research studies have demonstrated a decrease in health-related quality of life (HRQL) measures among obese children. Moreover, the causes of HRQL impairments are not completely clear. Adolescent obesity is oftentimes associated with other cardiometabolic risk factors (CRFs); hence, the aim of our research was to estimate the frequency of CRFs and to determine whether there is an association between CRFs and HRQL scores among obese adolescents. METHODS: Our research included 92 treatment-seeking obese adolescents (11-17 years), 34 males...
July 18, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28718873/clinical-features-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-a-study-of-25-patients-in-korea
#2
Jin Y Lee, Suh-Young Lee, Ji E Hahm, Jae W Ha, Chul W Kim, Sang S Kim
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare adverse drug reaction. This study aimed to evaluate the incidence of association with individual drugs, clinical manifestations, disease course, and outcomes of DRESS. METHODS: Using the criteria of the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR), the medical records of 25 patients diagnosed with DRESS between 2006 and 2015 were retrospectively reviewed...
July 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28717843/septic-arthritis-associated-with-systemic-sepsis
#3
Sung-Weon Jung, Dong-Hee Kim, Sung-Jin Shin, Byoung-Youl Kang, Yil-Ju Eho, Seong-Wook Yang
PURPOSE: Septic arthritis presents with good joint function, but sometimes leads to poor outcomes. Concurrent systemic sepsis has been regarded as the poor outcome, and the exact cause remains unclear. This paper was performed to identify factors associated with concurrent systemic sepsis and to research results to predict poor outcomes in patients with septic arthritis. METHODS: Laboratory and medical data were reviewed for 137 adults with acute septic arthritis who underwent open or arthroscopic surgical debridement at our institution between January 2005 and December 2014...
July 17, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28717776/a-retrospective-study-of-emergency-department-potassium-disturbances-severity-treatment-and-outcomes
#4
Adam J Singer, Henry C Thode, W Frank Peacock
OBJECTIVE: Disturbances in potassium (K) levels are relatively common and may be associated with significant morbidity and mortality; however, treatments vary. Our purpose was to determine the incidence, treatments, and outcomes associated with hyperkalemia and hypokalemia in emergency department (ED) patients. METHODS: We performed a structured, retrospective review of electronic medical records of consecutive adult ED patients with K measured while in the ED. Demographic, clinical, and laboratory data as well as treatments, disposition, and in-hospital complications were collected...
June 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/28717669/pitfalls-in-genetic-testing-a-case-of-a-snp-in-primer-annealing-region-leading-to-allele-dropout-in-brca1
#5
Felipe Carneiro Silva, Giovana Tardin Torrezan, Rafael Canfield Brianese, Raquel Stabellini, Dirce Maria Carraro
BACKGROUND: Hereditary breast and ovarian cancer is characterized by mutations in BRCA1 or BRCA2 genes and PCR-based screening techniques, such as capillary sequencing and next-generation sequencing (NGS), are considered gold standard methods for detection of pathogenic mutations in these genes. Single-nucleotide polymorphisms (SNPs) constitute a vast source of variation in the human genome and represent a risk for misdiagnosis in genetic testing, since the presence of a SNP in primer-annealing sites may cause false negative results due to allele dropout...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28717236/high-performance-micro-flow-cytometer-based-on-optical-fibres
#6
S Etcheverry, A Faridi, H Ramachandraiah, T Kumar, W Margulis, F Laurell, A Russom
Flow cytometry is currently the gold standard for analysis of cells in the medical laboratory and biomedical research. Fuelled by the need of point-of-care diagnosis, a significant effort has been made to miniaturize and reduce cost of flow cytometers. However, despite recent advances, current microsystems remain less versatile and much slower than their large-scale counterparts. In this work, an all-silica fibre microflow cytometer is presented that measures fluorescence and scattering from particles and cells...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716656/atomoxetine-in-abstinent-cocaine-users-cognitive-subjective-and-cardiovascular-effects
#7
Elise E DeVito, Aryeh I Herman, Noah S Konkus, Huiping Zhang, Mehmet Sofuoglu
No pharmacotherapies are approved for the treatment of cocaine use disorders (CUD). Behavioral treatments for CUD are efficacious for some individuals, but recovery rates from CUD remain low. Cognitive impairments in CUD have been linked with poorer clinical outcomes. Cognitive enhancing pharmacotherapies have been proposed as promising treatments for CUD. Atomoxetine, a norepinephrine transporter inhibitor, shows potential as a treatment for CUD based on its efficacy as a cognitive enhancer in other clinical populations and impact on addictive processes in preclinical and human laboratory studies...
July 14, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28716156/generic-atorvastatin-is-as-effective-as-the-brand-name-drug-lipitor-%C3%A2-in-lowering-cholesterol-levels-a-cross-sectional-retrospective-cohort-study
#8
Alexander Loch, Jan Philipp Bewersdorf, Daniel Kofink, Dzafir Ismail, Imran Zainal Abidin, Ramesh Singh Veriah
BACKGROUND: In a world of ever increasing health care costs, generic drugs represent a major opportunity to ensure access to essential medicines for people who otherwise would be unable to afford them. However, some clinicians and patients are still questioning the safety and effectiveness of generic formulations compared to the proprietary drugs necessitating further systematic research analyzing the generic drugs' efficacy. Our objective was to compare the lipid lowering effects of generic and branded atorvastatin...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28716067/molecular-characterization-of-group-a-rotaviruses-in-mukuru-slums-kenya-detection-of-novel-strains-circulating-in-children-below-5%C3%A2-years-of-age
#9
Joshua Ndung'u Gikonyo, James Nyangao, Cecilia Mbae, Carlene Sang, Eliud Njagi, Joseph Ngeranwa, Mathew Esona, Mapaseka L Seheri, Grace W Gitau, Kedra Raini, Samuel Kariuki
BACKGROUND: Gastroenteritis is a public health concern due to high morbidity and mortality among children. Rotaviruses are the leading etiological agents of severe gastroenteritis in children and accounts for more than half a million deaths per year in Africa. The study aimed at investigating the rotavirus genotypes that were circulating in children aged 5 years and below in and around Mukuru slums in Nairobi County Kenya. METHODS: A purposive cross sectional sampling method was applied where 166 samples were collected from children below 5 years of age and taken to Kenya Medical Research Institute virology laboratory...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28715527/screening-criteria-for-ophthalmic-manifestations-of-congenital-zika-virus-infection
#10
Andrea A Zin, Irena Tsui, Julia Rossetto, Zilton Vasconcelos, Kristina Adachi, Stephanie Valderramos, Umme-Aiman Halai, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Joel Carlos Barros Silveira Filho, Mitsue S Aibe, Ana Carolina C da Costa, Olivia A Zin, Rubens Belfort, Patricia Brasil, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira
Importance: Current guidelines recommend screening eye examinations for infants with microcephaly or laboratory-confirmed Zika virus infection but not for all infants potentially exposed to Zika virus in utero. Objective: To evaluate eye findings in a cohort of infants whose mothers had polymerase chain reaction-confirmed Zika virus infection during pregnancy. Design, Setting, and Participants: In this descriptive case series performed from January 2 through October 30, 2016, infants were examined from birth to 1 year of age by a multidisciplinary medical team, including a pediatric ophthalmologist, from Fernandes Figueira Institute, a Ministry of Health referral center for high-risk pregnancies and infectious diseases in children in Rio de Janeiro, Brazil...
July 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28715514/i-swot-as-instrument-to-individually-optimize-therapy-of%C3%A2-thoracoabdominal-aortic-aneurysms-effective-norm-compliant-and-meeting-the-needs
#11
A Sachweh, Y von Kodolitsch, T Kölbel, A Larena-Avellaneda, S Wipper, A M Bernhardt, E Girdauskas, C Detter, H Reichenspurner, C R Blankart, E S Debus
BACKGROUND: Guidelines summarize medical evidence, they identify the most efficient therapy under study conditions and recommend this therapy for use. The physician now has the challenge to translate a therapy that is efficient under laboratory conditions to a patient who is an individual person. To accomplish this task the physician has to make sure that (I) the ideal typical therapy is applicable and effective in this individual patient taking the special features into consideration, that (II) therapy is compliant with the norm including guidelines, laws and ethical requirements (conformity) and that (III) the therapy meets the patient's needs...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28715306/a-data-rich-longitudinal-wellness-study-for-the-digital-age-fixing-a-broken-medical-system-requires-data-about-each-patient
#12
Gustavo Glusman
We live in an age of plentiful information, collected continuously by pervasive gadgetry, distributed through digital and social networks, and mined deeply by ever-more-powerful analytics systems. And yet, one of the things we know the least about is our bodies. When it comes to our own health, we are driving blindly. Modern medicine has clearly been remarkably successful, as evidenced by continually growing life expectancies. For example, the number of people 65 and older in the United States has seen a steady increase over the last century, rising from 3...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28714771/acute-effect-of-static-stretching-on-lower-limb-movement-performance-by-using-stabl-virtual-reality-system
#13
Mariam A Ameer, Qassim I Muaidi
CONTEXT: The effect of acute static stretch (ASS) on the lower limb RT has been recently questioned to decrease the risk of falling and injuries in situations requiring a rapid reaction, as in the cases of balance disturbance. OBJECTIVE: The main purpose of this study was to detect the effect of ASS on the lower limb RT by using virtual reality device. DESIGN: Two Group Control Group design. SETTING: Research laboratory...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28714488/nasal-carriage-rate-of-methicillin-resistant-staphylococcus-aureus-among-health-care-workers-at-a-tertiary-care-hospital-in-kathmandu-nepal
#14
S Khatri, N D Pant, R Bhandari, K L Shrestha, C D Shrestha, N Adhikari, A Poudel
BACKGROUND: Methicillin-resistant Staphylococcus aureus is one of the most common causes of nosocomial infections. Due to its multidrug resistant nature; infections due to Methicillin-resistant Staphylococcus aureus are often very difficult to treat. Colonized health care workers are the important sources of Methicillin-resistant Staphylococcus aureus. The objectives of this study were to determine the nasal carriage rate of Methicillin-resistant Staphylococcus aureus among health care workers at Kathmandu Medical College and Teaching Hospital, Nepal and to assess their antimicrobial susceptibility patterns...
January 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28714377/ibrutinib-associated-tumor-lysis-syndrome-in-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-and-mantle-cell-lymphoma-a-case-series-and-review-of-the-literature
#15
Krystal S Titus-Rains, Jamie N Brown, Julia M Hammond
Background Tumor lysis syndrome results when intracellular contents are released during cell lysis. Ibrutinib, a Bruton tyrosine kinase inhibitor, is used for the treatment of chronic lymphocytic leukemia, small lymphocytic lymphoma, Waldenström's macroglobulinemia, mantle cell lymphoma, and marginal zone lymphoma. Tumor lysis syndrome caused by ibrutinib therapy is potentially life threatening, but is rare and not often reported in clinical trials. Objective The purpose of this case series is to describe the occurrence of tumor lysis syndrome in two patients initiated on ibrutinib, and to highlight the importance of close monitoring during therapy...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28713512/laboratory-evaluation-of-the-effect-of-unfilled-resin-after-the-use-of-self-etch-and-total-etch-dentin-adhesives-on-the-shear-bond-strength-of-composite-to-dentin
#16
Ehsan Baradaran Nasseri, Sara Majidinia, Davood Aghasizadeh Sharbaf
BACKGROUND: Based on the frequent application of composite resins as tooth-colored fillings, this method is considered a viable alternative to dental amalgam. However, this method has the low bond strength of the composite to dentin. To solve this issue, various dental adhesive systems with different characteristics have been developed by dentistry experts. AIM: To assess the effect of an additional layer of unfilled resin in self-etch and total-etch dentin adhesives on the shear bond strength (SBS) of composite to dentin...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713501/removal-of-acid-orange-7-dye-from-aqueous-solutions-by-adsorption-onto-kenya-tea-pulps-granulated-shape
#17
Behnaz Naraghi, Fahimeh Zabihi, Mohammad Reza Narooie, Mahdi Saeidi, Hamed Biglari
BACKGROUND AND AIM: Water resources pollution control is one of the main challenges of our time for researchers. Colored wastewater discharges caused by textile industry activities has added to the concern. In this study, removal of Acid Orange 7 dye (AO7) using Kenya Tea residue absorbent (granular) has been studied. METHODS: This cross-sectional study was conducted in 2016. In this work, initially, tea residue was prepared in three forms of raw, treated with concentrated phosphoric acid, and carbonated, at temperatures of 350, 450 and 500 °C in the chemistry laboratory of Gonabad University of Medical Sciences...
May 2017: Electronic Physician
https://www.readbyqxmd.com/read/28713083/regional-features-of-the-microbial-landscape-of-urine-and-comparative-evaluation-of-antimicrobial-therapy-in-children-with-cystitis
#18
Tetyana O Kryuchko, Vira P Kharshman, Inna M Nesina, Nataliia V Kuzmenko, Jaroslava M Oleksiienko
INTRODUCTION: Growing resistance of pathogens to antibiotics, including cross-resistance to other antimicrobial classes that are used in the treatment of recurrent infections of the lower urinary system in children demands constant control of issues of regional antibiotic resistance. In the present days, in the empirical treatment of such patients physicians still choose medications with preserved activity in relation to E. coli. The aim of our study was to investigate the regional features of microbial landscape of urine in children with cystitis and study the efficacy of 7-day administration of Furamag medicinal drug for the treatment of recurrent episodes of this disease in children...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28712817/clinical-features-and-dynamic-ordinary-laboratory-tests-differentiating-dengue-fever-from-other-febrile-illnesses-in-children
#19
Chih-Ho Chen, Yi-Chuan Huang, Kuang-Che Kuo, Chung-Chen Li
BACKGROUND: Dengue fever is not easily to be diagnosed before presentation of the classic symptoms. The study aimed to investigate the clinical features and dynamic laboratory tests in pediatric patients to facilitate dengue diagnosis. METHODS: This retrospective study examined the medical records of all pediatric patients who were clinically suspected to have dengue from June to December 2014. Laboratory-positive dengue cases were confirmed by detecting non-structural protein NS1, reverse transcription-polymerase chain reaction of dengue virus, and dengue-specific IgM seroconversion...
June 30, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28712673/extract-critical-factors-affecting-the-length-of-hospital-stay-of-pneumonia-patient-by-data-mining-case-study-an-iranian-hospital
#20
Naghmeh Khajehali, Somayeh Alizadeh
MOTIVATION: Pneumonia is a prevalent infection of lower respiratory tract caused by infected lungs. Length of stay (LOS) in hospital is one of the simplest and most important indicators in hospital activity that is used for different purposes. The aim of this study is to explore the important factors affecting the LOS of patients with pneumonia in hospitals. METHODS: The clinical data set for the study were collected from 387 patients in a specialized hospital in Iran between 2009 and 2015...
July 13, 2017: Artificial Intelligence in Medicine
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