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High sensitive troponin I

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https://www.readbyqxmd.com/read/29789900/associations-of-sensitive-cardiac-troponin-i-with-left-ventricular-morphology-function-and-prognosis-in-end-stage-renal-disease-patients-with-preserved-ejection-fraction
#1
Kenichiro Otsuka, Koki Nakanishi, Kenei Shimada, Haruo Nakamura, Hitoshi Inanami, Hiroki Nishioka, Kohei Fujimoto, Noriaki Kasayuki, Minoru Yoshiyama
Sensitive cardiac troponin I (cTnI) predicts all-cause and cardiovascular mortality in various clinical settings. However, its clinical significance in hemodialysis (HD) patients with preserved left ventricular ejection fraction (LVEF) has not been fully elucidated. This study investigated the association of cTnI with LV morphology and function, and its long-term outcome in HD patients with preserved LVEF. This prospective study consists of 96 HD patients with preserved LVEF (69 ± 8 years and 63% male) who underwent two-dimensional echocardiographic examination and biomarker tests including cTnI, brain natriuretic peptide, and high-sensitive C-reactive protein...
May 22, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29770799/heart-type-fatty-acid-binding-protein-h-fabp-as-a-biomarker-for-acute-myocardial-injury-and-long-term-post-ischemic-prognosis
#2
REVIEW
Xiao-Dong Ye, Yi He, Sheng Wang, Gordon T Wong, Michael G Irwin, Zhengyuan Xia
Acute myocardial infarction (AMI) is a life-threatening event. Even with timely treatment, acute ischemic myocardial injury and ensuing ischemia reperfusion injury (IRI) can still be difficult issues to tackle. Apart from radiological and other auxiliary examinations, laboratory tests of applicable cardiac biomarkers are also necessary for early diagnosis and close monitoring of this disorder. Heart-type fatty acid binding protein (H-FABP), which mainly exists inside cardiomyocytes, has recently emerged as a potentially promising biomarker for myocardial injury...
May 17, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29768313/the-incidence-of-myocardial-injury-after-loading-doses-of-clopidogrel-versus-prasugrel-in-the-candidates-for-percutaneous-coronary-intervention-a-randomized-controlled-trial
#3
Reza Rahmani, Laya Jiriaee, Zahra Jiriaee, Akbar Shafiee, Amir Farhang Zand Parsa
INTRODUCTION: Prevention of myocardial injury is an essential issue in percutaneous coronary intervention (PCI). We compared the incidence of myocardial injury after loading doses of clopidogrel versus prasugrel in the candidates for PCI. METHODS: In this randomized-controlled clinical trial, we enrolled 88 stable angina patients, candidate for PCI. Patients received either prasugrel (60 mg orally) (n = 42) or clopidogrel (600 mg orally) (n = 46). Serum levels of creatine phosphokinase muscle-brain type, cardiac troponin I, and high sensitive C-reactive protein were measured at baseline and 6 and 12 hours postprocedural...
June 2018: Critical Pathways in Cardiology
https://www.readbyqxmd.com/read/29760219/detectable-high-sensitivity-cardiac-troponin-within-the-population-reference-interval-conveys-high-5-year-cardiovascular-risk-an-observational-study
#4
Martin P Than, Sally J Aldous, Richard W Troughton, Christopher J Pemberton, A Mark Richards, Christopher M A Frampton, Christopher M Florkowski, Peter M George, Samantha Bailey, Joanna M Young, Louise Cullen, Jaimi H Greenslade, William A Parsonage, Brendan M Everett, W Frank Peacock, Allan S Jaffe, John W Pickering
BACKGROUND: Increased cardiac troponin I or T detected by high-sensitivity assays (hs-cTnI or hs-cTnT) confers an increased risk of adverse prognosis. We determined whether patients presenting with putatively normal, detectable cTn concentrations [> limit of detection and < upper reference limit (URL)] have increased risk of major adverse cardiovascular events (MACE) or all-cause mortality. METHODS: A prospective 5-year follow-up of patients recruited in the emergency department with possible acute coronary syndrome (ACS) and cTn concentrations measured with hs-cTnI (Abbott) and hs-cTnT (Roche) assays...
May 14, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29750939/first-high-sensitivity-cardiac-troponin-i-assay-cleared-by-the-united-states-food-and-drug-administration-validation-and-implications
#5
Robert H Christenson, Kristin Mullins, Show-Hong Duh
BACKGROUND: High-Sensitivity (hs) cardiac troponin (cTn) assays are categorized by two criteria: (i) cTn values above the limit of detection (LoD) for >50% of male and female healthy cohorts of ≥300 individuals; (ii) imprecision ≤10% total %CV for sex-specific 99th-percentile clinical decision values (CDVs). No documented hs-Tn assay has yet been FDA-cleared. METHODS: The PATHFAST cTnI-II assay's LoD was 2.3 ng/L using CLSI EP-17. The AACC Universal Sample Bank of 847 healthy men (50...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29750937/the-potential-role-of-a-turbidimetric-heart-type-fatty-acid-binding-protein-assay-to-aid-in-the-interpretation-of-persistently-elevated-non-changing-cardiac-troponin-i-concentrations
#6
Peter A Kavsak, Craig Ainsworth, Donald M Arnold, Terry Scott, Lorna Clark, Josko Ivica, Katharine Mackett, Richard Whitlock, Andrew Worster
BACKGROUND: Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H-FABP) might be useful in this setting to identify the etiology of abnormally high and non-changing cTn concentrations which could aid clinical decision making in the hospital setting...
May 8, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29746826/high-sensitivity-cardiac-troponin-i-and-risk-of-incident-atrial-fibrillation-hospitalisation-in-an-australian-community-based-cohort-the-busselton-health-study
#7
Kun Zhu, Joseph Hung, Mark Divitini, Kevin Murray, Ee Mun Lim, Andrew St John, John P Walsh, Matthew Knuiman
OBJECTIVE: The identification of individuals at risk of atrial fibrillation (AF) remains a challenge. We investigated whether high-sensitive cardiac troponin I (hs-cTnI) is an independent predictor of incident atrial fibrillation (AF) hospitalisation in an Australian community-based cohort. METHODS: Serum hs-cTnI was measured in 1641 men and 2189 women in the Busselton Health Study 1994/1995 Cohort aged 25-84 years at baseline. Data on incident AF hospitalisation over 20 years follow-up were obtained by data linkage...
May 7, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29735888/rapid-and-sensitive-detection-of-cardiac-troponin-i-for-point-of-care-tests-based-on-red-fluorescent-microspheres
#8
Yanxue Cai, Keren Kang, Qianru Li, Yu Wang, Xiaowei He
A reliable lateral flow immunoassay (LFIA) based on a facile one-step synthesis of single microspheres in combining with immunochromatography technique was developed to establish a new point-of-care test (POCT) for the rapid and early detection of cardiac troponin I (cTnI), a kind of cardiac specific biomarker for acute myocardial infarction (AMI). The double layered microspheres with clear core-shell structures were produced using soap-free emulsion polymerization method with inexpensive compounds (styrene and acrylic acid)...
May 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29725733/a-novel-fluorescent-aptasensor-for-the-highly-sensitive-and-selective-detection-of-cardiac-troponin-i-based-on-a-graphene-oxide-platform
#9
Dongkui Liu, Xing Lu, Yiwen Yang, Yunyun Zhai, Jian Zhang, Lei Li
Acute myocardial infarction (AMI) is one of the leading risks to global health. Thus, the rapid, accurate early diagnosis of AMI is highly critical. Human cardiac troponin I (cTnI) has been regarded as a golden biomarker for AMI due to its excellent selectivity. In this work, a novel fluorescent aptasensor based on a graphene oxide (GO) platform was developed for the highly sensitive and selective detection of cTnI. GO binds to the fluorescent anti-cTnI aptamer and quenches its fluorescence. In the presence of cTnI, the fluorescent anti-cTnI aptamer leaves the surface of GO, combines with cTnI because of the powerful affinity of the fluorescent anti-cTnI aptamer and cTnI, and then restores the fluorescence of the fluorescent anti-cTnI aptamer...
May 4, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29721000/association-between-preoperative-high-sensitive-troponin-i-levels-and-cardiovascular-events-after-hip-fracture-surgery-in-the-elderly
#10
Bum Sung Kim, Tae-Hoon Kim, Jeong-Hwan Oh, Chang Hee Kwon, Sung Hea Kim, Hyun-Joong Kim, Heung Kon Hwang, Sang-Man Chung
Objective: Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip fracture patients. Method: From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry...
March 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29710336/association-of-fibroblast-growth-factor-23-with-recurrent-cardiovascular-events-in-patients-after-an-acute-coronary-syndrome-a-secondary-analysis-of-a-randomized-clinical-trial
#11
Brian A Bergmark, Jacob A Udell, David A Morrow, Christopher P Cannon, Dylan L Steen, Petr Jarolim, Andrzej Budaj, Christian Hamm, Jianping Guo, KyungAh Im, Julia F Kuder, Eugene Braunwald, Marc S Sabatine, Michelle L O'Donoghue
Importance: Elevated fibroblast growth factor 23 (FGF-23) concentrations are associated with myocardial fibrosis and renin-angiotensin system upregulation, potentially providing prognostic information distinct from standard cardiovascular (CV) biomarkers. Objective: To evaluate the association of FGF-23 with recurrent CV events in patients after an acute coronary syndrome (ACS). Design, Setting, and Participants: C-terminal FGF-23 was measured in plasma samples using an established enzyme-linked immunosorbent assay system for 4947 patients within 30 days of ACS (median, 14 days) and with 1 additional CV risk factor in the Stabilization of Plaques Using Darapladib-Thrombolysis in Myocardial Infarction 52 (SOLID-TIMI 52) trial of the lipoprotein-associated phospholipase A2 inhibitor darapladib vs placebo performed from December 1, 2009, to April 24, 2014 (median follow-up, 2...
April 18, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29701123/cardiodynamicsgram-a-novel-tool-for-monitoring-cardiac-function-in-exercise-training
#12
Xu Wen, Bokai Guo, Yinglan Gong, Ling Xia, Jie Yu
This study evaluated the feasibility of cardiodynamicsgram (CDG) for monitoring the cardiac functions of athletes and exercisers. CDG could provide an effective, simple, and economical tool for exercise training. Seventeen middle-distance race athletes aged 14-28 years old were recruited. CDG tests and blood test including creatine kinase (CK), CK-MB isoenzyme, and high-sensitivity troponin I (hsTnI) were performed before a high-intensity prolonged training, as well as 2 and 14 h after training, respectively...
April 27, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29691270/combining-high-sensitivity-cardiac-troponin-i-and-cardiac-troponin-t-in-the-early-diagnosis-of-acute-myocardial-infarction
#13
Noreen van der Linden, Karin Wildi, Raphael Twerenbold, John W Pickering, Martin Than, Louise Cullen, Jaimi Greenslade, William Parsonage, Thomas Nestelberger, Jasper Boeddinghaus, Patrick Badertscher, Maria Rubini Giménez, Lieke J J Klinkenberg, Otto Bekers, Aline Schöni, Dagmar I Keller, Zaid Sabti, Christian Puelacher, Janosch Cupa, Lukas Schumacher, Nikola Kozhuharov, Karin Grimm, Samyut Shrestha, Dayana Flores, Michael Freese, Claudia Stelzig, Ivo Strebel, Òscar Miró, Katharina Rentsch, Beata Morawiec, Damian Kawecki, Wanda Kloos, Jens Lohrmann, A Mark Richards, Richard Troughton, Christopher Pemberton, Stefan Osswald, Marja P van Dieijen-Visser, Alma M Mingels, Tobias Reichlin, Steven J R Meex, Christian Mueller
Background -Combining two signals of cardiomyocyte injury, cardiac troponin I (cTnI) and T (cTnT), might overcome some individual pathophysiological and analytical limitations and thereby increase diagnostic accuracy for acute myocardial infarction (AMI) with a single blood draw. We aimed to evaluate the diagnostic performance of combinations of high sensitivity (hs) cTnI and hs-cTnT for the early diagnosis of AMI. Methods -The diagnostic performance of combining hs-cTnI (Architect, Abbott) and hs-cTnT (Elecsys, Roche) concentrations (sum, product, ratio and a combination algorithm) obtained at the time of presentation was evaluated in a large multicenter diagnostic study of patients with suspected AMI...
April 24, 2018: Circulation
https://www.readbyqxmd.com/read/29689564/pulmonary-exposure-to-particulate-matter-pm2-5-affects-the-sensitivity-to-myocardial-ischemia-reperfusion-injury-through-farnesoid-x-receptor-induced-autophagy
#14
Fei Tong, Hua Zhang
BACKGROUND/AIMS: The purpose of this study was to investigate the effect of administering particulate matter (PM2.5) to the lungs on the sensitivity to myocardial ischemia/reperfusion injury (MI/RI) and the role of farnesoid-X-receptor (FXR)-induced autophagy in this process. METHODS: Male Sprague Dawley (SD) rats were subjected to 45 min of ischemia, and the lungs were exposed to 2.0 mg of PM2.5 in 0.3 mL of normal saline 5 min before reperfusion. After 24 h of reperfusion, the blood and myocardium were collected, and the myocardial infarct sizes, activities of serum creatine kinase (CK) and lactate dehydrogenase (LDH), and levels of serum high sensitivity C-reactive protein (hsCRP), interleukin-4 (IL-4), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), cardiac troponin T (cTnT), P-selectin and D-dimer were measured via biochemical analysis...
April 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29672821/a-rapid-differential-effect-of-rosuvastatin-and-atorvastatin-on-high-sensitivity-cardiac-troponin-i-in-subjects-with-stable-cardiovascular-disease
#15
Mathijs C Bodde, Paul Welsh, Sandrin C Bergheanu, Willem M Lijfering, Bart Mertens, An-Ho Liem, Arnoud van der Laarse, Naveed Sattar, J Wouter Jukema
Serum troponin within the normal range is an emerging predictor of cardiovascular mortality. We aimed to determine how rapidly high-sensitivity troponin -I (hs-cTnI) levels are lowered by statin therapy in patients with stable cardiovascular disease. In the RADAR substudy, patients were randomized, to atorvastatin 20 mg/day (n = 39) or rosuvastatin 10 mg/day (n = 39) and up-titrated in 6 week intervals to 80 mg of atorvastatin or 40 mg of rosuvastatin. Hs-cTnI concentrations were measured at baseline and at 6 and 18 weeks of follow-up...
April 19, 2018: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29671536/high-sensitivity-troponin-i-of-less-than-5-ng-per-l-has-negative-predictive-value-of-99-9-for-cardiac-death-at-one-year
#16
David Slawson
No abstract text is available yet for this article.
March 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29669813/monophosphorylation-of-cardiac-troponin-i-at-ser23-24-is-sufficient-to-regulate-cardiac-myofibrillar-ca-2-sensitivity-and-calpain-induced-proteolysis
#17
Abel Martin-Garrido, Brandon J Biesiadecki, Hussam E Salhi, Yasin Shaifta, Cristobal G Dos Remedios, Serife Ayuz-Guner, Wenxuan Cai, Ying Ge, Metin Avkiran, Jonathan C Kentish
The acceleration of myocardial relaxation produced by β-adrenoceptor stimulation is mediated in part by protein kinase A (PKA)-mediated phosphorylation of cardiac troponin-I (cTnI), which decreases myofibrillar Ca2+ sensitivity. Previous evidence suggests that phosphorylation of both Ser23 and Ser24 in cTnI is required for this Ca2+ desensitization. PKA-mediated phosphorylation also partially protects cTnI from proteolysis by calpain. Here we report that protein kinase D (PKD) phosphorylates only one serine of cTnI Ser23/24...
April 18, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29660794/diagnostic-utility-of-cardiac-troponin-i-in-cats-with-hypertrophic-cardiomyopathy
#18
Yasutomo Hori, Masayuki Iguchi, Yasuhiro Heishima, Yohei Yamashita, Kensuke Nakamura, Atsushi Hirakawa, Akihito Kitade, Toshiki Ibaragi, Michio Katagi, Tamotsu Sawada, Masashi Yuki, Nobuyuki Kanno, Haruki Inaba, Noriko Isayama, Hideyuki Onodera, Naoki Iwasa, Mikio Kino, Mikihiro Narukawa, Syuhei Uchida
BACKGROUND: Cardiac troponin I (cTnI) is useful for assessing hypertrophic cardiomyopathy (HCM) in cats. OBJECTIVE: To measure plasma cTnI concentrations in healthy cats and evaluate the clinical utility of cTnI in determining the severity of HCM. ANIMALS: Clinically healthy cats (n = 88) and cats with HCM (n = 93). METHODS: Multicenter prospective study. Cats with HCM, including hypertrophic obstructive cardiomyopathy at various stages, were diagnosed using echocardiography...
April 16, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29628129/comparison-of-the-association-between-high-sensitivity-troponin-i-and-adverse-cardiovascular-outcomes-in-patients-with-versus-without-chronic-kidney-disease
#19
Pratik B Sandesara, Wesley T O'Neal, Ayman Samman Tahhan, Salim S Hayek, Suegene K Lee, Jay Khambhati, Matthew L Topel, Muhammad Hammadah, Ayman Alkhoder, Yi-An Ko, Mohamad Mazen Gafeer, Agim Beshiri, Gillian Murtagh, Jonathan H Kim, Peter Wilson, Leslee Shaw, Stephen E Epstein, Laurence S Sperling, Arshed A Quyyumi
It is unknown whether the association of high-sensitivity troponin I (hs-TnI) with adverse cardiovascular outcomes varies by the presence of chronic kidney disease (CKD). We examined the association of hs-TnI with adverse cardiovascular outcomes in those with and without CKD in 4,107 (mean age, 64 years; 63% men; 20% black) patients from the Emory Cardiovascular Biobank who underwent coronary angiography. CKD (n = 1,073) was defined as estimated glomerular filtration rate <60 ml/min/1.73 m2 or urine albumin/creatinine ratio >30 mg/g at baseline...
March 14, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29622596/risk-stratifying-chest-pain-patients-in-the-emergency-department-using-heart-grace-and-timi-scores-with-a-single-contemporary-troponin-result-to-predict-major-adverse-cardiac-events
#20
Peter D W Reaney, Hamish I Elliott, Awsan Noman, Jamie G Cooper
BACKGROUND: The majority of patients presenting to the ED with cardiac sounding chest pain have a non-diagnostic ECG and the problem of differentiating those suffering an acute coronary syndrome from those without is familiar to all ED clinical staff. To stratify risk in these patients, specific scores have been developed. Recent work has focused on incorporating newer high-sensitivity cardiac troponin (hs-cTn) assays; however, issues regarding performance and availability of these assays remain...
April 5, 2018: Emergency Medicine Journal: EMJ
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