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"Purpura nephritis"

Zhi Liu, Yu-Dan Wei, Yue Hou, Ying Xu, Xiu-Jiang Li, Yu-Jun Du
We aimed to investigate the differences in renal histopathological changes and laboratory parameters between adult and pediatric patients with Henoch-Schönlein purpura nephritis (HSPN), and to analyze the correlation between laboratory parameters and renal histopathological grading. A total of 139 patients diagnosed with HSPN between September 2010 and December 2014 at the First Hospital of Jilin University, China, were retrospectively reviewed. The clinical and pathological characteristics were examined and compared between the adult and the pediatric patients...
October 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
Meltem Erol, Ozgul Yigit, Mehmet Tasdemir, Ozlem Bostan Gayret, Ovgu Buke, Aysegul Gunes, Sahin Hamilcikan, Ozgur Kasapcopur
BACKGROUND: Matrix metalloproteinase-9 (MMP-9) is an enzyme implicated in the pathogenesis of renal diseases. Renal involvement is the principal cause of morbidity and mortality in children with Henoch-Schönlein purpura (HSP). OBJECTIVES: The aim of this study was to evaluate whether serum and urinary MMP-9 levels are associated with renal involvement in HSP. PATIENTS AND METHODS: We evaluated 40 children with HSP (patient group) and 27 healthy volunteer children (control group)...
August 2016: Iranian Journal of Pediatrics
Jong Hwan Jung
No abstract text is available yet for this article.
September 2016: Kidney Research and Clinical Practice
Haidong Fu, Jianhua Mao, Yanping Xu, Weizhong Gu, Xiujuan Zhu, Aimin Liu
OBJECTIVE: To investigate the outcomes of childhood diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis (DEP-HSPN) in response to early diagnosis and prompt treatment. METHODS: Eleven cases of DEP-HSPN in children were investigated in comparison to HSPN without diffuse endocapillary proliferation (non-DEP-HSPN). RESULTS: DEP-HSPN had a higher prevalence of nephrotic syndrome but a lower prevalence of hematuria compared to non-DEP-HSPN...
September 2016: Clinics
Shu-Jiong Mao, Xian-Mei Huang
No abstract text is available yet for this article.
August 2016: World Journal of Pediatrics: WJP
E D Xu, Y F Xiao, J J Wang, L Dong
Henoch-Schönlein purpura nephritis (HSPN), the most serious long-term complication of Henoch-Schönlein purpura, is one of the most common renal diseases in children. Matrix metalloproteinase-9 (MMP-9) is implicated in the pathogenesis of renal diseases. Genomic DNA was isolated from the venous blood leukocytes of 220 unrelated patients with HSPN and 205 unrelated healthy individuals. To identify markers contributing to genetic susceptibility to HSPN, this study examined the potential association between HSPN and four single nucleotide polymorphisms of the MMP-9 gene (MMP9) (rs17576, rs3918254, rs3787268, and rs2236416) by using the MassARRAY system...
2016: Genetics and Molecular Research: GMR
L I Xiao, Fengxia Lin, Rong Xiao, Chun Hu, Mingyang Deng, Daiqiang Li, Xiaoling She, Fuyou Liu, Lin Sun
The present study reports the case of a 42-year-old male with multiple myeloma (MM)-associated skin light chain amyloidosis who presented with skin purpura as the initial symptom, which was misdiagnosis as Henoch-Schönlein purpura nephritis prior to admission to the Second Xiangya Hospital (Changsha, Hunan, China). The patient presented with purpura, papules petechiae and spontaneous ecchymosis, which was located scattered around the neck, chest and limbs, accompanied by a small amount of bleeding in the conjunctival and oral mucosa, and a swollen tongue...
June 2016: Oncology Letters
Despina Eleftheriou, Paul A Brogan
Considerable therapeutic advances for the treatment of vasculitis of the young have been made in the past 10 years, including the development of outcome measures that facilitate clinical trial design. Notably, these include: a recognition that some patients with Kawasaki Disease require corticosteroids as primary treatment combined with IVIG; implementation of rare disease trial design for polyarteritis nodosa to deliver the first randomised controlled trial for children; first clinical trials involving children for anti-neutrophil cytoplasmic antibody (ANCA) vasculitis; and identification of monogenic forms of vasculitis that provide an understanding of pathogenesis, thus facilitating more targeted treatment...
2016: Pediatric Rheumatology Online Journal
Rafael N Moresco, Marijn M Speeckaert, Slawomir C Zmonarski, Magdalena Krajewska, Ewa Komuda-Leszek, Agnieszka Perkowska-Ptasinska, Loreto Gesualdo, Maria T Rocchetti, Sigurd E Delanghe, Raymond Vanholder, Wim Van Biesen, Joris R Delanghe
BACKGROUND: IgA nephropathy (IgAN) and Henoch-Schönlein purpura nephritis (HSPN) are glomerular diseases that share a common and central pathogenic mechanism. The formation of immune complexes containing IgA1, myeloid IgA Fc alpha receptor (FcαRI/CD89) and transglutaminase-2 (TG2) is observed in both conditions. Therefore, urinary CD89 and TG2 could be potential biomarkers to identify active IgAN/HSPN. METHODS: In this multicenter study, 160 patients with IgAN or HSPN were enrolled...
June 2016: BBA Clinical
Xintong Hu, Jiandong Tai, Zhihui Qu, Songchen Zhao, Li Zhang, Man Li, Xiguang Sun, Yanfang Jiang
BACKGROUND: Henoch-Schoenlein purpura is the one of most common types of systemic vasculitis that involves impaired renal function and Henoch-Schoenlein purpura nephritis (HSPN). The diagnosis of this condition is largely based on immunohistologic detection of immunoglobulin A1-containing immune complex in the glomerular deposits of mesangium. Despite clinical advances, the etiopathogenesis of HSPN is still largely unknown. METHODS: In this study, we enrolled 25 newly diagnosed HSPN patients and 14 healthy controls...
2016: PloS One
Shankar Prasad Yadav, Gauri Shankar Shah, Om Prakash Mishra, Nirmal Baral
Spectrum of renal disease varies in different ethnic population, geographical location, and by environmental factors. The purpose of this study was to find out the clinical spectrum and occurrence of different pediatric renal diseases at a teaching hospital in the Eastern part of Nepal. All cases of renal diseases from one month to 15 years of age, attending the pediatric renal outpatient department and/or were admitted to the wards during the period of February 2012 to January 2013, were included in the study...
March 2016: Saudi Journal of Kidney Diseases and Transplantation
Fang Wang, Ying-Hui Zhang
OBJECTIVE: To study the relationship of cystatin C (CysC), fibrinogen (Fbg), and 24-hour urinary protein with renal pathological grade in children with Henoch-Schönlein purpura nephritis (HSPN), and to explore their values. METHODS: The clinical data of 48 children diagnosed with HSPN by renal biopsy from January 2011 to January 2015 were reviewed. According to renal pathological grading, in the 48 children with HSPN, 12 had stage IIa or lower, 12 stage IIb, 17 stage IIIa, and 7 stage IIIb or higher...
March 2016: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Takafumi Yamakawa, Izumi Yamamoto, Yo Komatsuzaki, Takahito Niikura, Yusuke Okabayashi, Haruki Katsumata, Mayuko Kawabe, Ai Katsuma, Aki Mafune, Yasuyuki Nakada, Akimitsu Kobayashi, Yusuke Koike, Jun Miki, Hiroki Yamada, Yudo Tanno, Ichiro Ohkido, Nobuo Tsuboi, Hiroyasu Yamamoto, Takashi Yokoo
We report a case of recurrent Henoch-Schönlein purpura nephritis (HSPN) treated successfully with a tonsillectomy and steroid pulse therapy in a kidney transplant patient. A 29-year-old woman was admitted to our hospital for an episode biopsy; she had a serum creatinine (S-Cr) of 1.0 mg/dL and 1.34 g/day proteinuria 26 months after kidney transplantation. Histological examination revealed increased amounts of mesangial matrix and mesangial hypercellularity with IgA deposition. Of note, one glomerulus showed focal endocapillary proliferation and tuft necrosis...
July 2016: Nephrology
Shinichiro Ohara, Yukihiko Kawasaki, Ryo Maeda, Syuto Kanno, Yuichi Suzuki, Kazuhide Suyama, Mitsuaki Hosoya
BACKGROUND: Myeloid-related protein 8/14 (MRP8/14) forms stable heterodimers and is the major calcium-binding protein secreted by activated granulocytes and monocytes. We evaluated whether serum MRP8/14 level is a useful indicator for the differential diagnosis between glomerulonephritis (GN)- and minimal change disease (MC)- related nephrotic syndrome (NS). METHODS: We evaluated serum MRP8/14 complex levels in 37 NS patients with MC or GN. These patients were divided into two groups...
February 18, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
Zhihui Zhang, Songchen Zhao, Li Zhang, Rebecca Crew, Nan Zhang, Xiguang Sun, Yanfang Jiang
T follicular helper (TFH) cells play an important role in the humoral immune responses. The aim of this study was to examine the frequency of different subsets of CD4(+)CXCR5(+) TFH cells and B cells in patients with new-onset Henoch-Schönlein purpura nephritis (HSPN). The numbers of different subsets of CD4(+)CXCR5(+) TFH cells, B cells and the constituents of serum cytokines were detected in a total of 25 patients with newly diagnosed HSPN before and after treatment, and in 14 healthy controls (HC). The potential connection of these cells with the clinical characteristics in HSPN patients was analyzed...
March 2016: International Immunopharmacology
Cong Dou, Yuting Jin, Shuzhen Sun, Aihua Zhou, Xing Chen
OBJECTIVE: To investigate the characteristics,diagnosis and therapy of post-biopsy renal artery pseudoaneurysm in children and to study the clinical value of arterial embolization for traumatic renal hemorrhage when conservative treatment failed. METHOD: Data were compiled from medical records of a child in whom renal artery pseudoaneurysm occurred after biopsy in the Provincial Hospital Affiliated to Shandong University , and the related literature was reviewed to analyze the diagnosis and treatment of such pseudoaneurysm...
October 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Masahiro Kaneko, Yohei Ikezumi, Takeshi Yamada, Hiroya Hasegawa, Utako Kaneko, Akihiko Saitoh
Henoch-Schönlein purpura nephritis (HSPN) is one of the most common types of chronic glomerulonephritis in children; however, there have been few reports on the pathogenesis and management of grade VI HSPN. We present the case of a 6-year-old boy with grade VI HSPN accompanied by severe nephrotic syndrome and hypocomplementaemia. Immunohistological studies revealed profound glomerular accumulation of CD45- and CD68-positive inflammatory cells. Moreover, some cells expressed the proliferating marker proliferating cell nuclear antigen...
January 2016: Nephrology
Koichi Kamei, Masao Ogura, Mai Sato, Shuichi Ito, Kenji Ishikura
BACKGROUND: As the morphological and immunohistochemical manifestations of immunoglobulin A (IgA) nephropathy and Henoch-Schonlein purpura nephritis (HSPN) are very similar, they are considered to share a common pathogenesis. Although HSPN usually develops after the appearance of anaphylactoid purpura, we have encountered patients whose renal symptoms preceded purpura. METHODS: We reviewed the clinical courses of patients who were first diagnosed with IgA nephropathy, but developed purpura later, at the National Center for Child Health and Development in Tokyo, Japan...
May 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Patrick Hamilton, Olumide Ogundare, Ammar Raza, Arvind Ponnusamy, Julie Gorton, Hana Alachkar, Jamil Choudhury, Jonathan Barratt, Philip A Kalra
A 27-year-old man presented with a palpable purpuric skin rash and joint and abdominal pain in April 2010. He had acute kidney injury and his creatinine quickly deteriorated to 687 μmol/L, with associated nephrotic range proteinuria. Kidney biopsy showed crescentic Henoch-Schonlein nephritis. He was treated with intravenous cyclophosphamide and prednisolone despite which his renal function deteriorated; he required haemodialysis for a short duration and seven sessions of therapeutic plasma exchange (TPE)...
2015: Case Reports in Nephrology
Jan Novak, Dana Rizk, Kazuo Takahashi, XianWen Zhang, Qi Bian, Hirouki Ueda, Yoshimi Ueda, Colin Reily, Ling-Yun Lai, Chuanming Hao, Lea Novak, Zhi-Qiang Huang, Matthew B Renfrow, Hitoshi Suzuki, Bruce A Julian
BACKGROUND: IgA nephropathy, a frequent cause of end-stage renal disease, is an autoimmune disease wherein immune complexes consisting of IgA1 with galactose-deficient O-glycans (autoantigen) and anti-glycan autoantibodies deposit in glomeruli and induce renal injury. Multiple genetic loci associated with disease risk have been identified. The prevalence of risk alleles varies geographically, highest in eastern Asia and northern Europe, fewer in other parts of Europe and North America, and the least in Africa...
May 2015: Kidney Diseases
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