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"Purpura nephritis"

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https://www.readbyqxmd.com/read/29330742/henoch-sch%C3%A3-nlein-purpura-nephritis-initial-risk-factors-and-outcomes-in-a-latin-american-tertiary-center
#1
Izabel M Buscatti, Beatriz B Casella, Nadia E Aikawa, Andrea Watanabe, Sylvia C L Fahrat, Lucia M A Campos, Clovis Artur Silva
The objective of this study was to evaluate prevalence, initial risk factors, and outcomes in Henoch-Schönlein purpura nephritis (HSPN) patients in Latin America. Two hundred ninety-six patients (validated EULAR/PRINTO/PRES HSP criteria) were assessed by demographic data, clinical/laboratorial involvements, and treatments in the first 3 months after diagnosis. They were followed-up in a Latin American tertiary center and were divided in two groups: with and without nephritis. Persistent non-nephrotic proteinuria, nephrotic proteinuria, and acute/chronic kidney injury were also systematically evaluated at 1, 5, 10, and 15 years after diagnosis...
January 13, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29234893/the-clinical-relevance-of-plasma-cd147-basigin-in-biopsy-proven-kidney-diseases
#2
Yoshiko Mori, Tomohiro Masuda, Tomoki Kosugi, Tomoki Yoshioka, Mayuko Hori, Hiroshi Nagaya, Kayaho Maeda, Yuka Sato, Hiroshi Kojima, Noritoshi Kato, Takuji Ishimoto, Takayuki Katsuno, Yukio Yuzawa, Kenji Kadomatsu, Shoichi Maruyama
BACKGROUND: Precise understanding of kidney disease activity is needed to design therapeutic strategies. CD147/basigin is involved in the pathogenesis of acute kidney injury and renal fibrosis through inflammatory cell infiltration. The present study examined the clinical relevance of CD147 in biopsy-proven kidney diseases that lead to the progression of chronic kidney disease. METHODS: Kidney biopsy specimens and plasma and urine samples were obtained from patients with kidney diseases, including IgA nephropathy (IgAN), Henoch-Schönlein purpura nephritis (HSPN), diabetic kidney disease (DKD), focal segmental glomerulosclerosis (FSGS), and membranous nephropathy (MN), who underwent renal biopsy between 2011 and 2014...
December 12, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29229167/glomerular-diseases-in-children
#3
REVIEW
Scott E Wenderfer, Joseph P Gaut
Unique challenges exist in the diagnosis and treatment of glomerular diseases with their onset during childhood. Mounting evidence supports the notion that earlier onset cases occur due to larger numbers of genetic risk alleles. Nearly all causes of adult-onset glomerulonephritis, nephrotic syndrome, and thrombotic microangiopathy have also been described in children, although the prevalence of specific causes differs. Postinfectious glomerulonephritis, Henoch-Schönlein purpura nephritis, and minimal change disease remain the most common causes of glomerular disease in younger children in the United States and can be diagnosed clinically without need for biopsy...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29185209/value-of-the-oxford-classification-of-iga-nephropathy-in-children-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#4
Ke Xu, Lili Zhang, Jie Ding, Suxia Wang, Baige Su, Huijie Xiao, Fang Wang, Xuhui Zhong, Yanming Li
BACKGROUND: The widely used International Study of Kidney Disease in Children (ISKDC) classification for Henoch-Schönlein purpura nephritis (HSPN) does not completely correlate with the clinical presentation and long-term prognosis of this disease. Primary IgA nephropathy (IgAN) and HSPN share common features; thus, the Oxford classification of IgAN might be useful in predicting the long-term outcomes of HSPN. However, its value has not been confirmed in children with HSPN. METHODS: We selected children with HSPN diagnosed between 2003 and 2015, and reclassified their renal biopsies according to the Oxford classification scoring system...
November 28, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/29177628/mycophenolate-mofetil-following-glucocorticoid-treatment-in-henoch-sch%C3%A3-nlein-purpura-nephritis-the-role-of-early-initiation-and-therapeutic-drug-monitoring
#5
Agnes Hackl, Jan U Becker, Lisa M Körner, Rasmus Ehren, Sandra Habbig, Eva Nüsken, Kai-Dietrich Nüsken, Kathrin Ebner, Max C Liebau, Carsten Müller, Martin Pohl, Lutz T Weber
BACKGROUND: Henoch-Schönlein purpura (HSP) is the most common vasculitis in childhood and traditionally considered as a self-limiting disease. However, renal involvement can unfavorably determine long-term prognosis. The reported regimens to treat HSP nephritis (HSPN) are diverse, indicating that the most effective treatment remains controversial. METHODS: This retrospective, single-center study involved 18 patients presenting with HSPN and nephrotic-range proteinuria...
November 25, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29136888/urinary-metal-and-metalloid-biomarker-study-of-henoch-schonlein-purpura-nephritis-using-inductively-coupled-plasma-orthogonal-acceleration-time-of-flight-mass-spectrometry
#6
Zhifen Deng, Zhicong Yang, Xue Ma, Xiaoli Tian, Liangliang Bi, Bin Guo, Wei Wen, Huayun Han, Yanjie Huang, Shusheng Zhang
To obtain a better understanding as to whether concentration alterations of metals and metalloids in urine were related to Henoch-Schonlein purpura nephritis (HSPN), the profiles of as many as 29 elements in urine were compared among three groups, the Henoch-Schonlein purpura (HSP), HSPN and a healthy control group. To this end, a reliable method has been developed for the simultaneous quantification of multiple elements including Li, Be, B, Al, Sc, Ti, V, Cr, Mn, Fe, Ni, Co, Cu, Zn, Ga, Ge, As, Se, Rb, Sr, Mo, Cd, Sn, Sb, Cs, Ba, Tl, Pb and Bi in urine using inductively coupled plasma orthogonal acceleration time-of-flight mass spectrometry (ICP-oa-TOF-MS)...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29122357/kidney-injury-molecule-1-level-is-associated-with-the-severity-of-renal-interstitial-injury-and-prognosis-in-adult-henoch-sch%C3%A3-nlein-purpura-nephritis
#7
Yuanyuan Zhang, Aiju Li, Jiliang Wen, Junhui Zhen, Qiufa Hao, Yidan Zhang, Zhao Hu, Xiaoyan Xiao
BACKGROUND AND AIMS: Kidney injury molecule-1 (KIM-1) was identified the most highly upregulated protein in chronic kidney diseases and prolonged KIM-1 expression may be maladaptive. The present study was aimed to investigate urinary, renal and plasma KIM-1 levels and to analyze association between KIM-1 levels with clinical and pathological indexes in adult Henoch-Schönlein purpura (HSP) patients. METHODS: Twenty healthy individuals, 20 HSP patients without nephritis and 35 HSP patients with nephritis were recruited...
November 6, 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28990845/the-relationship-between-red-cell-distribution-width-and-the-risk-of-henoch-sch%C3%A3-nlein-purpura-nephritis
#8
X Zhu, M Zhang, F Lan, H Wei, Q He, S Li, X Qin
INTRODUCTION: Red blood cell distribution width (RDW) is elevated in various inflammatory diseases, but its clinical significance in Henoch-Schönlein purpura nephritis (HSPN) in unknown. The aim of this study was to determine the value of RDW as a risk factor or marker for HSPN in children. METHODS: This was a case-control study of 105 Henoch-Schönlein purpura (HSP) patients, 120 HSPN patients and 192 healthy controls. The relationship between RDW-coefficient of variation (RDW-CV) and the clinical characteristics of HSPN patients was determined by a multiple logistic regression analysis (MVLRA)...
October 9, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28983704/presentation-of-pediatric-henoch-sch%C3%A3-nlein-purpura-nephritis-changes-with-age-and-renal-histology-depends-on-biopsy-timing
#9
Imke Hennies, Charlotte Gimpel, Jutta Gellermann, Kristina Möller, Brigitte Mayer, Katalin Dittrich, Anja K Büscher, Matthias Hansen, Wiebke Aulbert, Elke Wühl, Richard Nissel, Gessa Schalk, Lutz T Weber, Michael Pohl, Simone Wygoda, Rolf Beetz, Günter Klaus, Henry Fehrenbach, Sabine König, Hagen Staude, Ortraud Beringer, Martin Bald, Ulrike Walden, Christian von Schnakenburg, Gunhard Bertram, Michael Wallot, Karsten Häffner, Thorsten Wiech, Peter F Hoyer, Martin Pohl
BACKGROUND: This study correlates the clinical presentation of Henoch-Schönlein purpura nephritis (HSPN) with findings on initial renal biopsy. METHODS: Data from 202 pediatric patients enrolled in the HSPN registry of the German Society of Pediatric Nephrology reported by 26 centers between 2008 and 2014 were analyzed. All biopsy reports were re-evaluated for the presence of cellular crescents or chronic pathological lesions (fibrous crescents, glomerular sclerosis, tubular atrophy >5%, and interstitial fibrosis >5%)...
October 5, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28975086/mycophenolate-mofetil-for-the-treatment-of-henoch-sch%C3%A3-nlein-purpura-nephritis-current-knowledge-and-new-concepts
#10
EDITORIAL
Azar Nickavar, Mahnaz Sadeghian
No abstract text is available yet for this article.
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28919104/elevated-urinary-monocyte-chemoattractant-protein-1-levels-in-children-with-henoch-schonlein-purpura-nephritis
#11
Jiapei Wang, Qianqian Ying, Shiling Zhong, Yuanling Chen, Yazhen Di, Xiahua Dai, Jika Zheng, Mengjiao Shen
BACKGROUND: Chemokine monocyte chemoattractant protein-1 (MCP-1) has been proved as a potential urinary biomarker in nephropathies. The aim of this study was to investigate the urinary monocyte chemoattractant protein-1 (MCP-1) levels and clinical significance in Henoch-Schonlein purpura (HSP) children with and without nephritis and determine the association of MCP-1 with proteinuria. METHODS: A total of 261 HSP children-with or without nephritis-and 84 healthy control children were enrolled in this study...
August 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28881507/-evidence-based-guideline-for-diagnosis-and-treatment-of-henoch-schonlein-purpura-nephritis-2016
#12
(no author information available yet)
No abstract text is available yet for this article.
September 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28822451/-the-value-of-serum-free-light-chain-in-differential-diagnosis-of-monoclonal-gammopathy-of-renal-significance
#13
C Li, Y B Wen, H Li, W Su, J Li, J F Cai, L M Chen, X M Li, X W Li
Objective: To investigate the value of serum free light chain (FLC) in differential diagnosis of monoclonal gammopathy of renal significance (MGRS). Methods: Forty-nine hospitalized patients who underwent renal biopsy in Peking Union Medical College Hospital between January 2013 and December 2015 were included. Monoclonal gammopathy was detected by serum protein electrophoresis (SPE), serum immunofixation electrophoresis (IFE), urine IFE and serum FLC. All patients were classified as MGRS (n=32) and monoclonal gammopathy of undetermined significance (MGUS) (n=17)...
August 8, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28709416/warfarin-induced-toxic-epidermal-necrolysis-in-combination-therapy-of-henoch-sch%C3%A3-nlein-purpura-nephritis-a-case-report
#14
Katsuaki Kasahara, Yoshimitsu Gotoh, Yoshiyuki Kuroyanagi, China Nagano
BACKGROUND: Toxic epidermal necrolysis (TEN) is a rare life-threatening condition almost exclusively attributed to drugs. The main etiologic factors for TEN are sulphonamides, anticonvulsants, and antibiotics; however, there are no published reports of warfarin causing TEN. CASE PRESENTATION: We present the case of a 3-year-old patient who developed TEN while receiving treatment for Henoch-Schönlein purpura nephritis (HSPN). With multiple-drug therapy comprising prednisolone, mizoribine, dipyridamole, and warfarin, it is difficult to detect which drug is the causative agent...
July 14, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28700526/urinary-macrophage-migration-inhibitory-factor-as-a-noninvasive-biomarker-in-pediatric-henoch-sch%C3%A3-nlein-purpura-nephritis
#15
Jiapei Wang, Yunyan Li, Yuanling Chen, Xiahua Dai, Yazhen Di, Mengjiao Shen, Qianqian Ying, Shiwei Fu, Yinjie Li
PURPOSES: The aims of this study were to investigate urinary macrophage migration inhibitory factor (MIF) levels and their clinical significance in Henoch-Schönlein purpura (HSP) children with or without nephritis (N) and to assess the influence of steroid treatment on the urine MIF levels of HSPN patients. METHODS: Group I comprised 35 children with HSPN who were examined twice (A before treatment and B after steroid treatment). Group II comprised 41 children with HSP...
August 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28680829/azathioprine-treatment-in-two-children-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#16
COMMENT
Meltem A Melikoğlu, Mehmet Melikoğlu, Emine E Ergul
No abstract text is available yet for this article.
June 2017: Kidney Research and Clinical Practice
https://www.readbyqxmd.com/read/28591051/association-between-red-blood-cell-distribution-width-and-henoch-schonlein-purpura-nephritis
#17
Hui Xu, Wei Li, Jian-Hua Mao, Yan-Xiang Pan
To investigate whether red blood cell distribution width (RDW) is a marker of the risk of Henoch-Schonlein purpura (HSP) nephritis (HSPN), a total of 669 HSP patients and 168 healthy controls were included in this retrospective study. Two hundred fifty-six (38.3%) of the patients had kidney involvement. Compared with the HSP group, RDW was significantly higher in the HSPN group (P < .001). Binary logistic regression identified that HSPN was independently associated with age, RDW, platelet, and total cholesterol (odds ratio = 1...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28515415/evaluation-of-mycophenolate-mofetil-and-low-dose-steroid-combined-therapy-in-moderately-severe-henoch-sch%C3%A3-nlein-purpura-nephritis
#18
Zhihong Lu, Junfeng Song, Jianhua Mao, Yonghui Xia, Caiyun Wang
BACKGROUND The most appropriate management of Henoch-Schönlein Purpura (HSP) nephritis with nephrotic-range proteinuria remains uncertain. The aim of this study was to evaluate the clinical therapeutic effects of mycophenolate mofetil and low-dose steroid in Henoch-Schönlein purpura nephritis (HSPN) with nephrotic-range proteinuria and pathological classification less than IV in children. MATERIAL AND METHODS The clinical effects of MMF and low-dose steroid therapy were studied in children with Henoch-Schönlein purpura nephritis manifested with nephrotic-range proteinuria, normal kidney function, and <50% crescents or sclerosing lesions on renal biopsy...
May 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28508980/an-adult-case-of-severe-steroid-resistant-henoch-sch%C3%A3-nlein-purpura-nephritis-treated-with-intravenous-cyclophosphamide-and-tonsillectomy
#19
Emi Sasaki, Maki Shibata, Asami Kato, Naoto Hamano, Takashi Katsuki, Manami Tada, Fumihiko Hinoshita
A previously healthy 37-year-old Canadian man living in Japan visited a hospital in Thailand while traveling because of edematous legs, purpura, arthralgia, bloody stool, and fever after an insect bite. Henoch-Schönlein purpura (HSP) was suspected. His creatinine level was 5.2 mg/dL. He was treated with oral prednisolone (PSL) and oral cyclophosphamide (CPA); after treatment, his creatinine level improved to 2.4 mg/dL. Upon returning to Japan, he was admitted to the National Center for Global Health and Medicine Hospital in Tokyo...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28428534/expression-of-acid-sensing-ion-channels-in-renal-tubular-epithelial-cells-and-their-role-in-patients-with-henoch-sch%C3%A3-nlein-purpura-nephritis
#20
Li-Ping Yuan, Yan Bo, Zhang Qin, Hua Ran, Wang Li, Yu-Fei Li, Gui Ming
BACKGROUND Acid-sensing ion channels (ASICs) are ligand-gated cation channels activated by extracellular protons. However, the role of ASICs in kidney diseases remains uncertain. This study investigated ASICs expression in kidney tissues and their role in the development of Henoch-Schönlein purpura nephritis (HSPN). MATERIAL AND METHODS The expression of ASIC subunits was examined by immunochemical techniques in the kidney tissue from HSPN patients. Acid-induced ASICs expression in cultured renal tubular epithelial cells was determined by quantitative RT-PCR analysis...
April 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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