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Water Fat MRI

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https://www.readbyqxmd.com/read/28432747/whole-body-adipose-tissue-and-lean-muscle-volumes-and-their-distribution-across-gender-and-age-mr-derived-normative-values-in-a-normal-weight-swiss-population
#1
Erika J Ulbrich, Daniel Nanz, Olof Dahlqvist Leinhard, Magda Marcon, Michael A Fischer
PURPOSE: To determine age- and gender-dependent whole-body adipose tissue and muscle volumes in healthy Swiss volunteers in Dixon MRI in comparison with anthropometric and bioelectrical impedance (BIA) measurements. METHODS: Fat-water-separated whole-body 3 Tesla MRI of 80 healthy volunteers (ages 20 to 62 years) with a body mass index (BMI) of 17.5 to 26.2 kg/m(2) (10 men, 10 women per decade). Age and gender-dependent volumes of total adipose tissue (TAT), visceral adipose tissue (VAT), total abdominal subcutaneous adipose tissue (ASAT) and total abdominal adipose tissue (TAAT), and the total lean muscle tissue (TLMT) normalized for body height were determined by semi-automatic segmentation, and correlated with anthropometric and BIA measurements as well as lifestyle parameters...
April 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28432403/bone-marrow-fat-content-in-70-adolescent-girls-with-anorexia-nervosa-magnetic-resonance-imaging-and-magnetic-resonance-spectroscopy-assessment
#2
Kirsten Ecklund, Sridhar Vajapeyam, Robert V Mulkern, Henry A Feldman, Jennifer M O'Donnell, Amy D DiVasta, Catherine M Gordon
BACKGROUND: Adolescents and women with anorexia nervosa have increased bone marrow fat and decreased bone formation, at least in part due to hormonal changes leading to preferential stem cell differentiation to adipocytes over osteoblasts. OBJECTIVE: The purpose of this study was to evaluate marrow fat content and correlate with age and disease severity using knee MRI with T1 relaxometry (T1-R) and MR spectroscopy (MRS) in 70 adolescents with anorexia nervosa. MATERIALS AND METHODS: We enrolled 70 girls with anorexia nervosa who underwent 3-T knee MRI with coronal T1-W images, T1-R and single-voxel proton MRS at 30 and 60 ms TE...
April 22, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28427472/optimising-conservative-management-of-chronic-low-back-pain-study-protocol-for-a-randomised-controlled-trial
#3
Katherine J Simson, Clint T Miller, Jon Ford, Andrew Hahne, Luana Main, Timo Rantalainen, Wei-Peng Teo, Megan Teychenne, David Connell, Guy Trudel, Guoyan Zheng, Gary Thickbroom, Daniel L Belavy
BACKGROUND: Lower back pain is a global health issue affecting approximately 80% of people at some stage in their life. The current literature suggests that any exercise is beneficial for reducing back pain. However, as pain is a subjective evaluation and physical deficits are evident in low back pain, using it as the sole outcome measure to evaluate superiority of an exercise protocol for low back pain treatment is insufficient. The overarching goal of the current clinical trial is to implement two common, conservative intervention approaches and examine their impact on deficits in chronic low back pain...
April 20, 2017: Trials
https://www.readbyqxmd.com/read/28403942/mr-signal-fat-fraction-analysis-and-t2-weighted-imaging-measure-bat-reliably-on-humans-without-cold-exposure
#4
Milja Holstila, Marko Pesola, Teemu Saari, Kalle Koskensalo, Juho Raiko, Ronald J H Borra, Pirjo Nuutila, Riitta Parkkola, Kirsi A Virtanen
OBJECTIVE: Brown adipose tissue (BAT) is compositionally distinct from white adipose tissue (WAT) in terms of triglyceride and water content. In adult humans, the most significant BAT depot is localized in the supraclavicular area. Our aim is to differentiate brown adipose tissue from white adipose tissue using fat T2* relaxation time mapping and signal-fat-fraction (SFF) analysis based on a commercially available modified 2-point-Dixon (mDixon) water-fat separation method. We hypothesize that magnetic resonance (MR) imaging can reliably measure BAT regardless of the cold-induced metabolic activation, with BAT having a significantly higher water and iron content compared to WAT...
May 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28401339/evaluation-of-the-r2-value-in-invasive-ductal-carcinoma-with-respect-to-hypoxic-related-prognostic-factors-using-iterative-decomposition-of-water-and-fat-with-echo-asymmetry-and-least-squares-emission-ideal
#5
Mari Miyata, Takatoshi Aoki, Shohei Shimajiri, Atsuji Matsuyama, Shunsuke Kinoshita, Masami Fujii, Takefumi Katsuki, Yuzuru Inoue, Yoshika Nagata, Yuko Tashima, Yukunori Korogi
OBJECTIVE: To correlate the R2* value obtained by iterative decomposition of water and fat with echo asymmetry and least-squares emission (IDEAL) with fibrotic focus (FF), microvessel density and hypoxic biomarker (HIF-1α) in breast carcinoma. METHODS: Forty-two patients who were diagnosed with invasive ductal carcinoma (IDC) of the breast underwent breast MRI including IDEAL before surgery. The entire region of interest (ROI) was delineated on the R2* map, and average tumour R2* value was calculated for each ROI...
April 11, 2017: European Radiology
https://www.readbyqxmd.com/read/28399917/metformin-and-sulodexide-restore-cardiac-microvascular-perfusion-capacity-in-diet-induced-obese-rats
#6
Judith van Haare, M Eline Kooi, Jurgen W G E van Teeffelen, Hans Vink, Jos Slenter, Hanneke Cobelens, Gustav J Strijkers, Dennis Koehn, Mark J Post, Marc van Bilsen
BACKGROUND: Disturbances in coronary microcirculatory function, such as the endothelial glycocalyx, are early hallmarks in the development of obesity and insulin resistance. Accordingly, in the present study myocardial microcirculatory perfusion during rest and stress was assessed following metformin or sulodexide therapy in a rat model of diet-induced obesity. Additionally, the effect of degradation of the glycocalyx on myocardial perfusion was assessed in chow-fed rats. METHODS: Rats were fed a high fat diet (HFD) for 8 weeks and were divided into a group without therapy, and groups that received the anti-diabetic drug metformin or the glycocalyx-stabilizing drug sulodexide in their drinking water during the last 4 weeks of the feeding period...
April 11, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28398929/comprehensive-dynamic-contrast-enhanced-3d-magnetic-resonance-imaging-of-the-breast-with-fat-water-separation-and-high-spatiotemporal-resolution-using-radial-sampling-compressed-sensing-and-parallel-imaging
#7
Thomas Benkert, Kai Tobias Block, Samantha Heller, Melanie Moccaldi, Daniel K Sodickson, Sungheon Gene Kim, Linda Moy
OBJECTIVES: The aim of this study was to assess the applicability of Dixon radial volumetric encoding (Dixon-RAVE) for comprehensive dynamic contrast-enhanced 3D magnetic resonance imaging (MRI) of the breast using a combination of radial sampling, model-based fat/water separation, compressed sensing, and parallel imaging. MATERIALS AND METHODS: In this Health Insurance Portability and Accountability Act-compliant prospective study, 24 consecutive patients underwent bilateral breast MRI, including both conventional fat-suppressed and non-fat-suppressed precontrast T1-weighted volumetric interpolated breath-hold examination (VIBE)...
April 11, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28382554/measurement-of-vertebral-bone-marrow-proton-density-fat-fraction-in-children-using-quantitative-water-fat-mri
#8
Stefan Ruschke, Amber Pokorney, Thomas Baum, Holger Eggers, Jeffrey H Miller, Houchun H Hu, Dimitrios C Karampinos
OBJECTIVES: To investigate the feasibility of employing a 3D time-interleaved multi-echo gradient-echo (TIMGRE) sequence to measure the proton density fat fraction (PDFF) in the vertebral bone marrow (VBM) of children and to examine cross-sectional changes with age and intra-individual variations from the lumbar to the cervical region in the first two decades of life. MATERIALS AND METHODS: Quantitative water-fat imaging of the spine was performed in 93 patients (49 girls; 44 boys; age median 4...
April 5, 2017: Magma
https://www.readbyqxmd.com/read/28363661/breast-fat-volume-measurement-using-wide-bore-3%C3%A2-t-mri-comparison-of-traditional-mammographic-density-evaluation-with-mri-density-measurements-using-automatic-segmentation
#9
E Petridou, M Kibiro, C Gladwell, P Malcolm, A Toms, A Juette, M Borga, O Dahlqvist Leinhard, T Romu, B Kasmai, E Denton
AIM: To compare magnetic resonance imaging (MRI)-derived breast density measurements using automatic segmentation algorithms with radiologist estimations using the Breast Imaging Reporting and Data Systems (BI-RADS) density classification. MATERIALS AND METHODS: Forty women undergoing mammography and dynamic breast MRI as part of their clinical management were recruited. Fat-water separated MRI images derived from a two-point Dixon technique, phase-sensitive reconstruction, and atlas-based segmentation were obtained before and after intravenous contrast medium administration...
March 28, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28343939/a-tale-of-gastric-layering-and-sieving-gastric-emptying-of-a-liquid-meal-with-water-blended-in-or-consumed-separately
#10
Guido Camps, Monica Mars, Cees de Graaf, Paul A M Smeets
BACKGROUND: The process of gastric emptying determines how fast gastric content is delivered to the small intestine. It has been shown that solids empty slower than liquids and that a blended soup empties slower than the same soup as broth and chunks, due to the liquid fraction emptying more quickly. This process of 'gastric sieving' has not been investigated for liquid foods. OBJECTIVE: To determine whether gastric sieving of water can also occur for liquid foods...
March 23, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28333540/current-state-of-the-art-mri-for-comprehensive-evaluation-of-potential-living-liver-donors
#11
Kartik S Jhaveri, Lijun Guo, Luís Guimarães
OBJECTIVE: This review focuses on the role of state-of-the-art MRI-based techniques for comprehensive evaluation of living donors providing single-visit assessment of the liver vasculature via MR angiography, of the biliary tract via conventional T2-weighted MR cholangiography and T1-weighted gadoxetate disodium-enhanced MR cholangiography, and of hepatic steatosis via T2*-corrected multiecho chemical shift-based water-fat separation MRI and high-speed T2-corrected multiecho MR spectroscopy...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28332039/combined-quantification-of-fatty-infiltration-t-1-relaxation-times-and-t-2-relaxation-times-in-normal-appearing-skeletal-muscle-of-controls-and-dystrophic-patients
#12
Benjamin Leporq, Arnaud Le Troter, Yann Le Fur, Emmanuelle Salort-Campana, Maxime Guye, Olivier Beuf, Shahram Attarian, David Bendahan
OBJECTIVES: To evaluate the combination of a fat-water separation method with an automated segmentation algorithm to quantify the intermuscular fatty-infiltrated fraction, the relaxation times, and the microscopic fatty infiltration in the normal-appearing muscle. MATERIALS AND METHODS: MR acquisitions were performed at 1.5T in seven patients with facio-scapulo-humeral dystrophy and eight controls. Disease severity was assessed using commonly used scales for the upper and lower limbs...
March 22, 2017: Magma
https://www.readbyqxmd.com/read/28324157/water-fat-mri-in-a-hibernator-reveals-seasonal-growth-of-white-and-brown-adipose-tissue-without-cold-exposure
#13
Amanda MacCannell, Kevin Sinclair, Lannette Friesen-Waldner, Charles A McKenzie, James F Staples
Obligate hibernators, such as ground squirrels, display circannual patterns which persist even under constant laboratory conditions, suggesting that they are regulated by endogenous rhythms. Brown adipose tissue (BAT) is important for thermogenesis during periodic arousals from hibernation when core body temperature rises spontaneously from 5 to 37 °C. In most small eutherians BAT growth requires several weeks of cold exposure. We hypothesized that in the thirteen-lined ground squirrel (Ictidomys tridecemlineatus), a hibernator, BAT growth is regulated, in part, by an endogenous rhythm and we predicted that this growth would precede the hibernation season without cold exposure...
March 21, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28306547/synthetic-ct-for-mri-based-liver-stereotactic-body-radiotherapy-treatment-planning
#14
Jeremy S Bredfeldt, Lianli Liu, Mary Feng, Yue Cao, James M Balter
A technique for generating MRI-derived synthetic CT volumes (MRCTs) is demonstrated in support of adaptive liver stereotactic body radiation therapy (SBRT). Under IRB approval, 16 subjects with hepatocellular carcinoma were scanned using a single MR pulse sequence (T1 Dixon). Air-containing voxels were identified by intensity thresholding on T1-weighted, water and fat images. The envelope of the anterior vertebral bodies was segmented from the fat image and fuzzy-C-means (FCM) was used to classify each non-air voxel as mid-density, lower-density, bone, or marrow in the abdomen, with only bone and marrow classified within the vertebral body envelope...
April 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28275542/parkinson-s-disease-diffusion-mri-is-not-affected-by-acute-antiparkinsonian-medication
#15
Jae Woo Chung, Roxana G Burciu, Edward Ofori, Priyank Shukla, Michael S Okun, Christopher W Hess, David E Vaillancourt
OBJECTIVE: A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time. METHODS: Fifteen PD patients underwent dMRI OFF and ON-medication one day apart. ON-medication, patients were tested approximately 45 min after their usual dose of antiparkinsonian medication...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28263827/a-fast-method-for-the-quantification-of-fat-fraction-and-relaxation-times-comparison-of-five-sites-of-bone-marrow
#16
Caroline Le Ster, Jérémy Lasbleiz, Stephan Kannengiesser, Raphaël Guillin, Giulio Gambarota, Hervé Saint-Jalmes
PURPOSE: Bone marrow is found either as red bone marrow, which mainly contains haematopoietic cells, or yellow bone marrow, which mainly contains adipocytes. In adults, red bone marrow is principally located in the axial skeleton. A recent study has introduced a method to simultaneously estimate the fat fraction (FF), the T1 and T2* relaxation times of water (T1w, T2*w) and fat (T1f and T2*f) in the vertebral bone marrow. The aim of the current study was to measure FF, T1w, T1f, T2*w and T2*f in five sites of bone marrow, and to assess the presence of regional variations...
March 2, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28263425/fast-bilateral-breast-coverage-with-high-spectral-and-spatial-resolution-hiss-mri-at-3t
#17
Milica Medved, Hui Li, Hiroyuki Abe, Deepa Sheth, Gillian M Newstead, Olufunmilayo I Olopade, Maryellen L Giger, Gregory S Karczmar
PURPOSE: To develop and assess a full-coverage, sensitivity encoding (SENSE)-accelerated breast high spatial and spectral resolution (HiSS) magnetic resonance imaging (MRI) within clinically reasonable times as a potential nonenhanced MRI protocol for breast density measurement or breast cancer screening. MATERIALS AND METHODS: Sixteen women with biopsy-proven cancer or suspicious lesions, and 13 women who were healthy volunteers or were screened for breast cancer, received 3T breast MRI exams, including SENSE-accelerated HiSS MRI, which was implemented as a submillimeter spatial resolution echo-planar spectroscopic imaging (EPSI) sequence...
March 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28247430/a-novel-phase-unwrapping-method-based-on-pixel-clustering-and-local-surface-fitting-with-application-to-dixon-water-fat-mri
#18
Junying Cheng, Yingjie Mei, Biaoshui Liu, Jijing Guan, Xiaoyun Liu, Ed X Wu, Qianjin Feng, Wufan Chen, Yanqiu Feng
PURPOSE: To develop and evaluate a novel 2D phase-unwrapping method that works robustly in the presence of severe noise, rapid phase changes, and disconnected regions. THEORY AND METHODS: The MR phase map usually varies rapidly in regions adjacent to wraps. In contrast, the phasors can vary slowly, especially in regions distant from tissue boundaries. Based on this observation, this paper develops a phase-unwrapping method by using a pixel clustering and local surface fitting (CLOSE) approach to exploit different local variation characteristics between the phase and phasor data...
March 1, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28244504/ambulatory-function-in-motor-incomplete-spinal-cord-injury-a-magnetic-resonance-imaging-study-of-spinal-cord-edema-and-lower-extremity-muscle-morphometry
#19
A C Smith, K A Weber, T B Parrish, T G Hornby, V M Tysseling, J G McPherson, M Wasielewski, J M Elliott
STUDY DESIGN: This research utilized a cross-sectional design. OBJECTIVES: Spinal cord edema length has been measured with T2-weighted sagittal MRI to predict motor recovery following spinal cord injury. The purpose of our study was to establish the correlational value of axial spinal cord edema using T2-weighted MRI. We hypothesized a direct relationship between the size of damage on axial MRI and walking ability, motor function and distal muscle changes seen in motor incomplete spinal cord injury (iSCI)...
February 28, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28244136/improved-fat-suppression-of-the-breast-using-discretized-frequency-shimming
#20
Tijl A van der Velden, Peter R Luijten, Dennis W J Klomp
PURPOSE: Robust fat suppression is essential in bilateral breast MRI at 7 Tesla. The lack of good fat suppression can result in errors when calculating the enhancement curve from dynamic contrast-enhanced acquisitions. In this work we propose discretized frequency shimming to improve the quality of fat suppression by exploiting the capabilities of a parallel transmit setup. METHODS: With discretized frequency shimming, different resonance frequencies are used for the different transmitters of the radiofrequency coil...
February 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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