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Susceptibility Weighted Imaging

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https://www.readbyqxmd.com/read/28935928/location-of-cerebral-microbleeds-and-their-association-with-carotid-intima-media-thickness-a-community-based-study
#1
Chih-Ping Chung, Kun-Hsien Chou, Wei-Ta Chen, Li-Kuo Liu, Wei-Ju Lee, An-Chun Huang, Liang-Kung Chen, Ching-Po Lin, Pei-Ning Wang
To assess whether high cerebral microbleeds (CMBs) are associated with carotid intima-media thickness (CIMT), a marker of systemic atherosclerosis, we cross-sectionally evaluated participants from a community-based study, the I-Lan Longitudinal Aging Study. The participants' demographics and cardiovascular risk factors were determined by questionnaire and/or laboratory measurements. CIMT was measured by ultrasonography. CMBs were assessed by susceptibility-weighted-imaging on 3 T MRI. Of the 962 subjects [62...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28932410/quantitative-characterization-of-optic-nerve-atrophy-in-patients-with-multiple-sclerosis
#2
Robert L Harrigan, Alex K Smith, Bailey Lyttle, Bailey Box, Bennett A Landman, Francesca Bagnato, Siddharama Pawate, Seth A Smith
BACKGROUND: Optic neuritis (ON) is one of the most common presentations of multiple sclerosis (MS). Magnetic resonance imaging (MRI) of the optic nerves is challenging because of retrobulbar motion, orbital fat and susceptibility artifacts from maxillary sinuses; therefore, axonal loss is investigated with the surrogate measure of a single heuristically defined point along the nerve as opposed to volumetric investigation. OBJECTIVE: The objective of this paper is to derive optic nerve volumetrics along the entire nerve length in patients with MS and healthy controls in vivo using high-resolution, clinically viable MRI...
July 2017: Multiple Sclerosis Journal—Experimental, Translational and Clinical
https://www.readbyqxmd.com/read/28922367/perihematomal-diffusion-restriction-as-a-common-finding-in-large-intracerebral-hemorrhages-in-the-hyperacute-phase
#3
Tanja Schneider, David Frieling, Julian Schroeder, Jan Regelsberger, Gerhard Schoen, Jens Fiehler, Susanne Gellißen
PURPOSE: There is growing evidence that a perihematomal area of restricted diffusion (PDR) exists in intraparenchymal hemorrhages (IPH) within 1 week of symptom onset (SO). Here, we study characteristics and the clinical impact of the PDR in patients with hyperacute (≤ 6 hours from SO) IPH by means of apparent diffusion coefficient (ADC). METHODS: This monocentric, retrospective study includes 83 patients with first-ever primary IPH from 09/2002-10/2015. 3D volumetric segmentation was performed for the IPH, PDR, and perihematomal edema (PHE) on fluid-attenuated inversion recovery, T2*/susceptibility weighted images, and ADC images...
2017: PloS One
https://www.readbyqxmd.com/read/28917813/structural-impacts-on-the-timing-and-amplitude-of-the-negative-bold-response
#4
David Provencher, Alexandre Bizeau, Guillaume Gilbert, Yves Bérubé-Lauzière, Kevin Whittingstall
The positive (PBR) and negative BOLD responses (NBR) arising in task-fMRI display varying magnitudes and dynamics across voxels. While the effects of structure, particularly of veins, on the PBR have been studied, little is known of NBR-structure relationships. Like the PBR, the NBR is often used as a surrogate marker of neuronal activation in both basic and clinical research and assessing its relationship with cortical structure may help interpret group differences. We therefore investigated how local structure affects BOLD amplitude and timing in PBR and NBR areas using multi-band fMRI during visual stimulation to obtain high temporal resolution (TR=0...
September 13, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28904470/susceptibility-weighted-imaging-torch-fire-sign-in-a-patient-with-dystonia-due-to-hypoxic-ischemic-injury
#5
Savith Kumar, Chandrasekharan Kesavadas, Bejoy Thomas
No abstract text is available yet for this article.
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28889091/mri-in-sarcoglycanopathies-a-large-international-cohort-study
#6
Giorgio Tasca, Mauro Monforte, Jordi Díaz-Manera, Giacomo Brisca, Claudio Semplicini, Adele D'Amico, Fabiana Fattori, Anna Pichiecchio, Angela Berardinelli, Lorenzo Maggi, Elio Maccagnano, Nicoline Løkken, Chiara Marini-Bettolo, Francina Munell, Angel Sanchez, Nahla Alshaikh, Nicol C Voermans, Jahannaz Dastgir, Dmitry Vlodavets, Jana Haberlová, Gianmichele Magnano, Maggie C Walter, Susana Quijano-Roy, Robert-Yves Carlier, Baziel G M van Engelen, John Vissing, Volker Straub, Carsten G Bönnemann, Eugenio Mercuri, Francesco Muntoni, Elena Pegoraro, Enrico Bertini, Bjarne Udd, Enzo Ricci, Claudio Bruno
OBJECTIVES: To characterise the pattern and spectrum of involvement on muscle MRI in a large cohort of patients with sarcoglycanopathies, which are limb-girdle muscular dystrophies (LGMD2C-2F) caused by mutations in one of the four genes coding for muscle sarcoglycans. METHODS: Lower limb MRI scans of patients with LGMD2C-2F, ranging from severe childhood variants to milder adult-onset forms, were collected in 17 neuromuscular referral centres in Europe and USA...
September 9, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28886909/quantitative-susceptibility-mapping-differentiates-between-parkinsonian-disorders
#7
Henrik Sjöström, Tobias Granberg, Eric Westman, Per Svenningsson
INTRODUCTION: It is often challenging to clinically distinguish between Parkinson's disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP). Quantitative susceptibility mapping (QSM) is an accurate indirect method for estimating brain iron levels in vivo. This method has yet to be applied in atypical parkinsonism. We aimed to investigate differences in brain iron accumulation parkinsonian disorders and healthy controls using QSM. METHODS: 15 patients with PSP, 11 patients with MSA, 62 patients with PD and 14 healthy controls were included in the study and their phase and magnitude data from susceptibility-weighted magnetic resonance imaging were retrospectively analyzed with an in-house pipeline to create susceptibility maps...
September 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28885746/pseudo-extravasation-rate-constant-of-dynamic-susceptibility-contrast-mri-determined-from-pharmacokinetic-first-principles
#8
Xin Li, Csanad G Varallyay, Seymur Gahramanov, Rongwei Fu, William D Rooney, Edward A Neuwelt
Dynamic susceptibility contrast-magnetic resonance imaging (DSC-MRI) is widely used to obtain informative perfusion imaging biomarkers, such as the relative cerebral blood volume (rCBV). The related post-processing software packages for DSC-MRI are available from major MRI instrument manufacturers and third-party vendors. One unique aspect of DSC-MRI with low-molecular-weight gadolinium (Gd)-based contrast reagent (CR) is that CR molecules leak into the interstitium space and therefore confound the DSC signal detected...
September 8, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28884957/long-term-sequelae-of-hippocampal-lesions-in-patients-with-transient-global-amnesia-a-multiparametric-mri-study
#9
Xiaochuan Wang, Ran Zhang, Wenping Wei, Haibo Jiang, Zhongming Gao, Jianzhong Lin, Jiaxing Zhang
BACKGROUND: MRI signal diffusion-weighted imaging (DWI) hyperintensity in the hippocampus in patients with transient global amnesia (TGA) are resolved within several days after the onset of TGA. PURPOSE: To use multiparametric MRI to unravel the sequelae of TGA. STUDY TYPE: A prospective longitudinal study. POPULATION: Eight TGA patients. FIELD STRENGTH/SEQUENCE: A 3.0T Siemens Tim Trio MRI scanner with T1 -weighted MPRAGE, diffusion-weighted echo planar imaging, and multiecho gradient-recalled echo sequences...
September 7, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28879406/whole-tumor-histogram-analysis-of-the-cerebral-blood-volume-map-tumor-volume-defined-by-11c-methionine-positron-emission-tomography-image-improves-the-diagnostic-accuracy-of-cerebral-glioma-grading
#10
Rongli Wu, Yoshiyuki Watanabe, Atsuko Arisawa, Hiroto Takahashi, Hisashi Tanaka, Yasunori Fujimoto, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa, Noriyuki Tomiyama
PURPOSE: This study aimed to compare the tumor volume definition using conventional magnetic resonance (MR) and 11C-methionine positron emission tomography (MET/PET) images in the differentiation of the pre-operative glioma grade by using whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) maps. MATERIALS AND METHODS: Thirty-four patients with histopathologically proven primary brain low-grade gliomas (n = 15) and high-grade gliomas (n = 19) underwent pre-operative or pre-biopsy MET/PET, fluid-attenuated inversion recovery, dynamic susceptibility contrast perfusion-weighted magnetic resonance imaging, and contrast-enhanced T1-weighted at 3...
September 6, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28879204/dynamic-susceptibility-contrast-perfusion-magnetic-resonance-imaging-demonstrates-reduced-periventricular-cerebral-blood-flow-in-dogs-with-ventriculomegaly
#11
Martin J Schmidt, Malgorzata Kolecka, Robert Kirberger, Antje Hartmann
The nature of ventriculomegaly in dogs is still a matter of debate. Signs of increased intraventricular pressure and atrophy of the cerebral white matter have been found in dogs with ventriculomegaly, which would imply increased intraventricular pressure and, therefore, a pathological condition, i.e., to some extent. Reduced periventricular blood flow was found in people with high elevated intraventricular pressure. The aim of this study was to compare periventricular brain perfusion in dogs with and without ventriculomegaly using perfusion weighted-magnetic-resonance-imaging to clarify as to whether ventriculomegaly might be associated with an increase in intraventricular pressure...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28866787/iron-metabolism-and-its-detection-through-mri-in-parkinsonian-disorders-a-systematic-review
#12
REVIEW
Sara Pietracupa, Antonio Martin-Bastida, Paola Piccini
Iron deposition in the brain normally increase with age, but its accumulation in certain regions is observed in a number of neurodegenerative diseases including Parkinson's disease (PD) and other parkinsonisms. Whether iron overload leads to dopaminergic neuronal death in the SN of PD patients or is instead simply a by-product of the neurodegenerative progression is still yet to be ascertained. Magnetic resonance imaging (MRI) is a non-invasive method to assess brain iron content in PD patients. In PD, accurate radiologic visualization of basal ganglia is required...
September 2, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28841802/advanced-magnetic-resonance-imaging-in-glioblastoma-a-review
#13
Gaurav Shukla, Gregory S Alexander, Spyridon Bakas, Rahul Nikam, Kiran Talekar, Joshua D Palmer, Wenyin Shi
Glioblastoma, the most common and most rapidly progressing primary malignant tumor of the central nervous system, continues to portend a dismal prognosis, despite improvements in diagnostic and therapeutic strategies over the last 20 years. The standard of care radiographic characterization of glioblastoma is magnetic resonance imaging (MRI), which is a widely utilized examination in the diagnosis and post-treatment management of patients with glioblastoma. Basic MRI modalities available from any clinical scanner, including native T1-weighted (T1w) and contrast-enhanced (T1CE), T2-weighted (T2w), and T2-fluid-attenuated inversion recovery (T2-FLAIR) sequences, provide critical clinical information about various processes in the tumor environment...
August 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28838910/assessment-of-iron-deposition-in-the-brain-in-frontotemporal-dementia-and-its-correlation-with-behavioral-traits
#14
R Sheelakumari, C Kesavadas, T Varghese, R M Sreedharan, B Thomas, J Verghese, P S Mathuranath
BACKGROUND AND PURPOSE: Brain iron deposition has been implicated as a major culprit in the pathophysiology of neurodegeneration. However, the quantitative assessment of iron in behavioral variant frontotemporal dementia and primary progressive aphasia brains has not been performed, to our knowledge. The aim of our study was to investigate the characteristic iron levels in the frontotemporal dementia subtypes using susceptibility-weighted imaging and report its association with behavioral profiles...
August 24, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28826581/uncommon-causes-of-cerebral-microbleeds
#15
REVIEW
Nariman Noorbakhsh-Sabet, Varun Chandi Pulakanti, Ramin Zand
BACKGROUND: Cerebral microbleeds (CMBs) are small and round perivascular hemosiderin depositions detectable by gradient echo sequences or susceptibility-weighted imaging. Cerebral microbleeds are common among patients with hypertension, cerebral ischemia, or cerebral amyloid angiopathy. In this article, we describe uncommon causes of CMBs. METHODS: We searched Pubmed with the keyword CMBs for relevant studies and looked for different uncommon causes of CMBs. RESULTS: CMBs have several uncommon etiologies including posterior reversible encephalopathy syndrome, infective endocarditis, brain radiation therapy, cocaine abuse, thrombotic thrombocytopenic purpura, traumatic brain injury, intravascular lymphomatosis or proliferating angio-endotheliomatosis, moyamoya disease, sickle cell anemia/β-thalassemia, cerebral autosomal dominant arteriopathy subcortical infarcts, and leukoencephalopathy (CADASIL), genetic syndromes, or obstructive sleep apnea...
August 17, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28815906/deep-gray-matter-iron-measurement-in-patients-with-liver-cirrhosis-using-quantitative-susceptibility-mapping-relationship-with-pallidal-t1-hyperintensity
#16
Song Lee, Yoonho Nam, Jinhee Jang, Gun Hyung Na, Dong Goo Kim, Na-Young Shin, Hyun Seok Choi, So-Lyung Jung, Kook-Jin Ahn, Bum-Soo Kim
BACKGROUND: The liver is a central organ for the metabolism of iron and manganese and the places where those metals are commonly deposited overlap in the brain. PURPOSE/HYPOTHESIS: To elucidate the relationship between pallidal T1 hyperintensity and iron deposition in the deep gray matter of liver cirrhosis patients using quantitative susceptibility mapping (QSM). STUDY TYPE: Retrospective case-control study SUBJECTS: In all, 38 consecutive liver cirrhosis patients who received brain magnetic resonance imaging (MRI) as pretransplant evaluation...
August 17, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28814097/prominent-deep-medullary-veins-a-predictive-biomarker-for-stroke-risk-from-transient-ischemic-attack
#17
Yang Duan, Zhihua Xu, Hongyi Li, Xiaonan Cai, Cancan Chang, Benqiang Yang
Background Deep medullary veins (DMVs) are a biomarker of severity and prognosis in patients with acute cerebral infarction. However, their clinical significance remains unclear in patients with transient ischemic attack (TIA). Purpose To determine whether prominent deep medullary veins (PDMVs) are a predictive biomarker for stroke risk after TIA. Material and Methods Clinical and imaging data of 49 patients with TIA and 49 sex- and age-matched controls were studied. PDMVs were defined as DMVs with a score of 3 (TDMVs) or asymmetric DMVs (ADMVs), and the relationship between PDMVs and clinical features was analyzed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28804112/low-signal-intensity-lesions-on-brain-susceptibility-weighted-mri-in-a-patient-with-intravascular-large-b-cell-lymphoma
#18
Yo Tsuda, Takuya Oguri, Keita Sakurai, Tomohiro Kajiguchi, Hideki Kato, Hiroyuki Yuasa
A 71-year-old man was admitted to our hospital because of abnormal behavior and generalized convulsion. Brain MRI revealed no abnormalities upon admission. Levels of serum lactate dehydrogenase and soluble interleukin-2 receptors were significantly elevated, whereas the initial bone marrow puncture and random skin biopsy findings were non-malignant. On the tenth day of admission, brain MRI revealed dot and strip-shaped low signal intensity lesions on susceptibility-weighted images (SWI) disseminated mainly within the cerebral cortex...
August 11, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/28800410/incident-risk-and-progression-of-cerebral-microbleeds-in-healthy-adults-a-multi-occasion-longitudinal-study
#19
Ana M Daugherty, Naftali Raz
Decline in cerebrovascular health complicates brain aging, and development of cerebral microbleeds (CMBs) is one of its prominent indicators. In a large sample of healthy adults (N = 251, age 18-78 years at baseline, 70% women), the contributions of chronological age and vascular health indicators to the risk of developing a CMB, as well as the change in CMB size and iron content, were examined in a prospective 8-year longitudinal study using susceptibility weighted imaging. Twenty-six persons (10.4%), most of whom were 40 years of age or older, had at least 1 CMB during the study...
July 18, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28781924/cerebral-microhemorrhage-a-frequent-magnetic-resonance-imaging-finding-in-pediatric-patients-after-cardiopulmonary-bypass
#20
Paggie P C Kim, Benjamin W Nasman, Erica L Kinne, Udochukwu E Oyoyo, Daniel K Kido, J P Jacobson
OBJECTIVES: This study was undertaken to estimate the incidence and burden of cerebral microhemorrhage (CM) in patients with heart disease who underwent cardiopulmonary bypass (CPB), as detected on susceptibility-weighted imaging (SWI), a magnetic resonance (MR) sequence that is highly sensitive to hemorrhagic products. MATERIALS AND METHODS: With Institutional Review Board waiver of consent, MR imaging (MRI) of a cohort of 86 consecutive pediatric patients with heart failure who underwent heart transplantation evaluation were retrospectively reviewed for CM...
2017: Journal of Clinical Imaging Science
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