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Susceptibility Weighted Imaging

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https://www.readbyqxmd.com/read/28439322/susceptibility-imaging-in-glial-tumor-grading-using-3-tesla-magnetic-resonance-mr-system-and-32-channel-head-coil
#1
Omer Aydin, Ramazan Buyukkaya, Bahattin Hakyemez
BACKGROUND: Susceptibility weighted imaging (SWI) is a velocity compensated, high-resolution three-dimensional (3D) spoiled gradient-echo sequence that uses magnitude and filtered-phase data. SWI seems to be a valuable tool for non-invasive evaluation of central nervous system gliomas. Relative cerebral blood volume (rCBV) ratio is one of the best noninvasive methods for glioma grading. Degree of intratumoral susceptibility signal (ITSS) on SWI correlates with rCBV ratio and histopathological grade...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28438711/can-transverse-relaxation-rates-in-deep-gray-matter-be-approximated-from-functional-and-t2-weighted-flair-scans-for-relative-brain-iron-quantification
#2
Benjamín Garzón, Rouslan Sitnikov, Lars Bäckman, Grégoria Kalpouzos
Alterations in iron concentration in certain deep gray matter regions are known to occur in aging and several clinical conditions. In vivo measurements of R2(∗) transverse relaxation rates and quantitative susceptibility mapping (QSM) have been shown to be strongly correlated with iron concentration in tissue, but their calculation requires the acquisition of a multi-echo gradient recalled echo sequence (MGRE). In the current study, we examined the feasibility of approximating R2(∗) rates using metrics derived from fMRI-EPI and T2-weighted FLAIR images, which are widely available...
April 21, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28435102/simultaneous-time-interleaved-multislice-stims-for-rapid-susceptibility-weighted-acquisition
#3
Berkin Bilgic, Huihui Ye, Lawrence L Wald, Kawin Setsompop
T2⁎ weighted 3D Gradient Echo (GRE) acquisition is the main sequence used for Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM). These applications require a long echo time (TE) to build up phase contrast, requiring a long repetition time (TR), and leading to excessively lengthy scans. The long TE acquisition creates a significant amount of unused time within each TR, which can be utilized for either multi-echo sampling or additional image encoding with the echo-shift technique...
April 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28432264/prediction-of-stroke-subtype-and-recanalization-using-susceptibility-vessel-sign-on-susceptibility-weighted-magnetic-resonance-imaging
#4
Dong-Wan Kang, Han-Gil Jeong, Do Yeon Kim, Wookjin Yang, Seung-Hoon Lee
BACKGROUND AND PURPOSE: The susceptibility vessel sign (SVS) is a hypointense signal visualized because of the susceptibility effect of thrombi, sensitively detected on susceptibility-weighted magnetic resonance imaging. The relationship of SVS parameters with the stroke subtype and recanalization status after endovascular treatment remains uncertain. METHODS: The data from 89 patients with acute stroke caused by anterior circulation infarcts who underwent susceptibility-weighted magnetic resonance imaging before endovascular treatment were examined...
April 21, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28427705/presence-of-central-veins-and-susceptibility-weighted-imaging-for-evaluating-lesions-in-multiple-sclerosis-and-leukoaraiosis
#5
Urška Lamot, Jernej Avsenik, Saša Šega, Katarina Šurlan Popovič
PURPOSE: The process of demyelination in multiple sclerosis (MS) is reflected in lesions of the central nervous system (CNS), which are found in an abundance of different diseases and are frequently radiographically indistinguishable. Our aim was to determine whether the perivenous distribution of MS lesions identified on susceptibility weighted images (SWI) could be used as a specific radiographic sign for MS, and also to determine whether the visibility of the central vein (CV) is affected by the activity of MS lesions...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28427600/carotid-artery-stenting-investigation-of-plaque-protrusion-incidence-and-prognosis
#6
Masashi Kotsugi, Katsutoshi Takayama, Kaoru Myouchin, Takeshi Wada, Ichiro Nakagawa, Hiroyuki Nakagawa, Toshiaki Taoka, Shinichiro Kurokawa, Hiroyuki Nakase, Kimihiko Kichikawa
OBJECTIVES: This study sought to clarify the incidence and prognosis of PP in carotid artery stenting (CAS). BACKGROUND: Projections thought to be plaque may be observed inside the stent on angiography or intravascular ultrasound (IVUS) during CAS. Known as plaque protrusion (PP), the incidence and prognosis of this complication are unclear. METHODS: A total of 354 consecutive carotid atherosclerotic stenoses in 328 patients (285 men, 43 women; age range 51 to 97 years [mean age 73...
April 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28424751/levodopa-responsive-parkinsonism-in-patients-with-hemochromatosis-case-presentation-and-literature-review
#7
Tarun Girotra, Abhimanyu Mahajan, Christos Sidiropoulos
Hemochromatosis is an autosomal recessive disorder which leads to abnormal iron deposition in the parenchyma of multiple organs causing tissue damage. Accumulation of iron in the brain has been postulated to be associated with several neurodegenerative diseases including Parkinson's disease. The excess iron promotes Parkin and α-synuclein aggregation in the neurons. Excess iron has also been noted in substantia nigra on MRI especially using susceptibility weighted imaging in patients with Parkinson's disease...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28424015/susceptibility-weighted-imaging-in-acute-cerebral-ischemia-review-of-emerging-technical-concepts-and-clinical-applications
#8
Charlie Chia-Tsong Hsu, Gigi Nga Chi Kwan, Sachintha Hapugoda, Michelle Craigie, Trevor William Watkins, E Mark Haacke
Susceptibility weighted imaging (SWI) is an essential magnetic resonance imaging sequence in the assessment of acute ischemic stroke. In this article, we discuss the physics principals and clinical application of conventional SWI and multi-echo SWI sequences. We review the research evidence and practical approach of SWI in acute ischemic stroke by focusing on the detection and characterization of thromboembolism in the cerebral circulation. In addition, we discuss the role of SWI in the assessment of neuroparenchyma by depiction of asymmetric hypointense cortical veins in the ischemic territory (surrogate tissue perfusion), detection of existing microbleeds before stroke treatment and monitoring for hemorrhagic transformation post-treatment...
April 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28423027/comparison-of-t2-weighted-and-qsm-contrasts-in-parkinson-s-disease-to-visualize-the-stn-with-mri
#9
Anneke Alkemade, Gilles de Hollander, Max C Keuken, Andreas Schäfer, Derek V M Ott, Johannes Schwarz, David Weise, Sonja A Kotz, Birte U Forstmann
The subthalamic nucleus (STN) plays a crucial role in the surgical treatment of Parkinson's disease (PD). Studies investigating optimal protocols for STN visualization using state of the art magnetic resonance imaging (MRI) techniques have shown that susceptibility weighted images, which display the magnetic susceptibility distribution, yield better results than T1-weighted, T2-weighted, and T2*-weighted contrasts. However, these findings are based on young healthy individuals, and require validation in elderly individuals and persons suffering from PD...
2017: PloS One
https://www.readbyqxmd.com/read/28409357/diffusion-weighted-mri-to-assess-response-to-chemoradiotherapy-in-rectal-cancer-main-interpretation-pitfalls-and-their-use-for-teaching
#10
Doenja M J Lambregts, Miriam M van Heeswijk, Andrea Delli Pizzi, Saskia G C van Elderen, Luisa Andrade, Nicky H G M Peters, Peter A M Kint, Margreet Osinga-de Jong, Shandra Bipat, Rik Ooms, Max J Lahaye, Monique Maas, Geerard L Beets, Frans C H Bakers, Regina G H Beets-Tan
OBJECTIVES: To establish the most common image interpretation pitfalls for non-expert readers using diffusion-weighted imaging (DWI) to assess response to chemoradiotherapy in patients with rectal cancer and to explore the use of these pitfalls in an expert teaching setting. METHODS: Two independent non-expert readers (R1 and R2) scored the restaging DW MRI scans (b1,000 DWI, in conjunction with ADC maps and T2-W MRI scans for anatomical reference) in 100 patients for the likelihood of a complete response versus residual tumour using a five-point confidence score...
April 13, 2017: European Radiology
https://www.readbyqxmd.com/read/28399448/apparent-diffusion-coefficient-adc-of-the-vitreous-humor-and-susceptibility-weighted-imaging-swi-of-the-retina-in-abused-children-with-retinal-hemorrhages
#11
Misun Hwang, Samuel S Shin, Matthew A Thimm, Anish Ghodadra, Christin L Sylvester, Ken Nischal, Ashok Panigrahy, Giulio Zuccoli
This study speculated that the apparent diffusion coefficient (ADC) of the vitreous humor might be altered in the setting of abusive head trauma (AHT) with retinal hemorrhages (RH). Fourty-four subjects were analyzed (n=20 AHT cases; n=24 controls). There was no statistically significant difference in normalized ADC values between the cases and controls (-0.14 and -0.08 respectively, p=0.46), but analysis of RH by susceptibility weighted imaging (SWI) compared to dilated funduscopic exam demonstrated statistically significant correlation (p=0...
April 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28397986/clinical-and-metabolic-correlates-of-cerebral-calcifications-in-sturge-weber-syndrome
#12
Vinod K Pilli, Michael E Behen, Jiani Hu, Yang Xuan, James Janisse, Harry T Chugani, Csaba Juhász
AIM: To evaluate clinical and metabolic correlates of cerebral calcifications in children with Sturge-Weber syndrome (SWS). METHOD: Fifteen children (11 females, four males; age range 7mo-9y, mean 4y 1mo) with unilateral SWS underwent baseline and follow-up magnetic resonance imaging (MRI) with susceptibility weighted imaging (SWI), glucose metabolism positron emission tomography (PET), and neurocognitive assessment (mean follow-up 1y 8mo). Calcified brain volumes measured on SWI were correlated with areas of abnormal glucose metabolism, seizure variables, and cognitive function (IQ)...
April 11, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28393012/the-effect-of-repetitive-subconcussive-collisions-on-brain-integrity-in-collegiate-football-players-over-a-single-football-season-a-multi-modal-neuroimaging-study
#13
Semyon M Slobounov, Alexa Walter, Hans C Breiter, David C Zhu, Xiaoxiao Bai, Tim Bream, Peter Seidenberg, Xianglun Mao, Brian Johnson, Thomas M Talavage
The cumulative effect of repetitive subconcussive collisions on the structural and functional integrity of the brain remains largely unknown. Athletes in collision sports, like football, experience a large number of impacts across a single season of play. The majority of these impacts, however, are generally overlooked, and their long-term consequences remain poorly understood. This study sought to examine the effects of repetitive collisions across a single competitive season in NCAA Football Bowl Subdivision athletes using advanced neuroimaging approaches...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28385516/proximal-bright-vessel-sign-on-arterial-spin-labeling-magnetic-resonance-imaging-in-acute-cardioembolic-cerebral-infarction
#14
Ayumi Kato, Yuki Shinohara, Keita Kuya, Makoto Sakamoto, Hisanori Kowa, Toshihide Ogawa
BACKGROUND: The congestion of spin-labeled blood at large-vessel occlusion can present as hyperintense signals on perfusion magnetic resonance imaging with 3-dimensional pseudo-continuous arterial spin labeling (proximal bright vessel sign). The purpose of this study was to clarify the difference between proximal bright vessel sign and susceptibility vessel sign in acute cardioembolic cerebral infarction. METHODS: Forty-two patients with cardioembolic cerebral infarction in the anterior circulation territory underwent magnetic resonance imaging including diffusion-weighted imaging, 3-dimensional pseudo-continuous arterial spin labeling perfusion magnetic resonance imaging, T2*-weighted imaging, and 3-dimensional time-of-flight magnetic resonance angiography using a 3-T magnetic resonance scanner...
April 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28382536/follow-up-assessment-of-coiled-intracranial-aneurysms-using-zte-mra-as-compared-with-tof-mra-a-preliminary-image-quality-study
#15
Song'an Shang, Jing Ye, Xianfu Luo, Jianxun Qu, Yong Zhen, Jingtao Wu
OBJECTIVES: To prospectively assess coiled intracranial aneurysms using a novel non-contrast enhanced zero echo time (zTE) MR angiography (MRA) method, and compare its image quality with time-of-flight (TOF) MRA, using digital subtraction angiography (DSA) as reference. METHODS: Twenty-five patients (10 males and 15 females; age 53.96 ± 12.46 years) were enrolled in this monocentric study. MRA sequences were performed 24 h before DSA. Susceptibility artefact intensity and flow signal within the parent artery were carried out using a 4-point scale...
April 5, 2017: European Radiology
https://www.readbyqxmd.com/read/28382379/posttreatment-dsc-mri-is-predictive-of-early-treatment-failure-in-children-with-supratentorial-high-grade-glioma-treated-with-erlotinib
#16
John T Lucas, Brendan J Knapp, Jinsoo Uh, Chia-Ho Hua, Thomas E Merchant, Scott N Hwang, Zoltan Patay, Alberto Broniscer
BACKGROUND AND PURPOSE: The role of perfusion imaging in the management of pediatric high grade glioma is unclear. We evaluated the ability of dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) to determine grade, evaluate post-treatment response and predict treatment failure. MATERIAL AND METHODS: In this study 22 patients with high-grade glioma underwent biopsy and were treated with concurrent and sequential radiotherapy and erlotinib as part of a phase I/II clinical trial (NCT00124657)...
April 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28379574/the-role-of-angiogenesis-in-group-3-medulloblastoma-pathogenesis-and-survival
#17
Eric M Thompson, Stephen T Keir, Talaignair Venkatraman, Christopher Lascola, Kristen W Yeom, Andrew B Nixon, Yingmiao Liu, Daniel Picard, Marc Remke, Darell D Bigner, Vijay Ramaswamy, Michael D Taylor
Background: Of the 4 medulloblastoma subgroups, Group 3 is the most aggressive but the importance of angiogenesis is unknown. This study sought to determine the role of angiogenesis and identify clinically relevant biomarkers of tumor vascularity and survival in Group 3 medulloblastoma. Methods: VEGFA mRNA expression and survival from several patient cohorts were analyzed. Group 3 xenografts were implanted intracranially in nude rats. Dynamic susceptibility weighted (DSC) MRI and susceptibility weighted imaging (SWI) were obtained...
April 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28374764/amide-proton-transfer-magnetic-resonance-imaging-in-detecting-intracranial-hemorrhage-at-different-stages-a-comparative-study-with-susceptibility-weighted-imaging
#18
Xiaoyue Ma, Yan Bai, Yusong Lin, Xiaohua Hong, Taiyuan Liu, Lun Ma, E Mark Haacke, Jinyuan Zhou, Jian Wang, Meiyun Wang
Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) technique based on the chemical exchange-dependent saturation transfer mechanism. The purpose of this study was to investigate the diagnostic performance of APT MRI in detecting intracranial hemorrhage (ICH) at hyperacute, acute and subacute stages by comparing with susceptibility weighted imaging (SWI). APT MRI and SWI were performed on 33 included patients with ICH by using a 3-T MRI unit. A two-sided Mann-Whitney U test was used to detect differences in APT-weighted (APTw) and SWI signal intensities of ICH at hyperacute, acute and subacute stages...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372502/chemistry-and-redox-biology-of-mycothiol
#19
Aníbal Marcelo Reyes, Brandán Pedre Pérez, María Inés De Armas, Maria-Armineh Tossounian, Rafael Radi, Joris Messens, Madia Trujillo
SIGNIFICANCE: Mycothiol (MSH, AcCys-GlcN-Ins) is the main low molecular weight thiol of most Actinomycetes, including the human pathogen Mycobacterium tuberculosis that affects millions of people worldwide. Strains with decreased MSH content show increased susceptibilities to hydroperoxides and electrophilic compounds. In M. tuberculosis, MSH modulates the response to several anti-tuberculosis drugs. Enzymatic routes involving MSH could provide clues for specific drug design. Recent Advances...
April 3, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28360997/imaging-biomarkers-in-parkinson-s-disease-and-parkinsonian-syndromes-current-and-emerging-concepts
#20
REVIEW
Usman Saeed, Jordana Compagnone, Richard I Aviv, Antonio P Strafella, Sandra E Black, Anthony E Lang, Mario Masellis
Two centuries ago in 1817, James Parkinson provided the first medical description of Parkinson's disease, later refined by Jean-Martin Charcot in the mid-to-late 19th century to include the atypical parkinsonian variants (also termed, Parkinson-plus syndromes). Today, Parkinson's disease represents the second most common neurodegenerative disorder with an estimated global prevalence of over 10 million. Conversely, atypical parkinsonian syndromes encompass a group of relatively heterogeneous disorders that may share some clinical features with Parkinson's disease, but are uncommon distinct clinicopathological diseases...
2017: Translational Neurodegeneration
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