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Simon Haziza, Nitin Mohan, Yann Loe-Mie, Aude-Marie Lepagnol-Bestel, Sophie Massou, Marie-Pierre Adam, Xuan Loc Le, Julia Viard, Christine Plancon, Rachel Daudin, Pascale Koebel, Emilie Dorard, Christiane Rose, Feng-Jen Hsieh, Chih-Che Wu, Brigitte Potier, Yann Herault, Carlo Sala, Aiden Corvin, Bernadette Allinquant, Huan-Cheng Chang, François Treussart, Michel Simonneau
Brain diseases such as autism and Alzheimer's disease (each inflicting >1% of the world population) involve a large network of genes displaying subtle changes in their expression. Abnormalities in intraneuronal transport have been linked to genetic risk factors found in patients, suggesting the relevance of measuring this key biological process. However, current techniques are not sensitive enough to detect minor abnormalities. Here we report a sensitive method to measure the changes in intraneuronal transport induced by brain-disease-related genetic risk factors using fluorescent nanodiamonds (FNDs)...
November 28, 2016: Nature Nanotechnology
Brian Egan, Chih-Chi Yuan, Madeleine Lisa Craske, Paul Labhart, Gulfem D Guler, David Arnott, Tobias M Maile, Jennifer Busby, Chisato Henry, Theresa K Kelly, Charles A Tindell, Suchit Jhunjhunwala, Feng Zhao, Charlie Hatton, Barbara M Bryant, Marie Classon, Patrick Trojer
Chromatin immunoprecipitation and DNA sequencing (ChIP-seq) has been instrumental in inferring the roles of histone post-translational modifications in the regulation of transcription, chromatin compaction and other cellular processes that require modulation of chromatin structure. However, analysis of ChIP-seq data is challenging when the manipulation of a chromatin-modifying enzyme significantly affects global levels of histone post-translational modifications. For example, small molecule inhibition of the methyltransferase EZH2 reduces global levels of histone H3 lysine 27 trimethylation (H3K27me3)...
2016: PloS One
Jahaira Capellan, Mary H Wilde, Feng Zhang
PURPOSE: The objective of this article is to describe how self-monitoring contributed to measurement reactivity in a randomized clinical trial (RCT). The implications of measurement reactivity on self-monitoring and suggestions for minimizing its effect will be discussed. DESIGN: The study involved a secondary data analysis of responses from 145 participants who completed a 12-month long RCT. The original sample consisted of 202 community-living adults with long-term indwelling urinary catheters...
November 16, 2016: Journal of Nursing Scholarship
Mary Lou Warren, Sam Yerramsetti, Nick Holton, Jeffrey Bruno, Neetha Jawe, April Finnigan, Nisha Rathi, Lei Feng
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Yan Zhang, Wei-Xu Feng, Yves-Marie Legrand, Claudiu T Supuran, Cheng-Yong Su, Mihail Barboiu
A facile lipase activation has been achieved by direct addition of multivalent amide dynameric frameworks into the reaction aqueous solutions, through the combined effects of lipase-host matrices, H-bonds and interfacial interactions.
November 8, 2016: Chemical Communications: Chem Comm
Christina Yacoob, Marie Pancera, Vladimir Vigdorovich, Brian G Oliver, Jolene A Glenn, Junli Feng, D Noah Sather, Andrew T McGuire, Leonidas Stamatatos
Elicitation of broadly neutralizing antibodies remains a long-standing goal of HIV vaccine research. Although such antibodies can arise during HIV-1 infection, gaps in our knowledge of their germline, pre-immune precursor forms, as well as on their interaction with viral Env, limit our ability to elicit them through vaccination. Studies of broadly neutralizing antibodies from the VRC01-class provide insight into progenitor B cell receptors (BCRs) that could develop into this class of antibodies. Here, we employed high-throughput heavy chain variable region (VH)/light chain variable region (VL) deep sequencing, combined with biophysical, structural, and modeling antibody analyses, to interrogate circulating potential VRC01-progenitor BCRs in healthy individuals...
November 1, 2016: Cell Reports
Zhendong Fu, Yinguo Xiao, Artem Feoktystov, Vitaliy Pipich, Marie-Sousai Appavou, Yixi Su, Erxi Feng, Wentao Jin, Thomas Brückel
The magnetic-field-induced assembly of magnetic nanoparticles (NPs) provides a unique and flexible strategy in the design and fabrication of functional nanostructures and devices. We have investigated the field-induced self-assembly of core-shell iron oxide NPs dispersed in toluene by means of small-angle neutron scattering (SANS). The form factor of the core-shell NPs was characterized and analyzed using SANS with polarized neutrons. Large-scale aggregates of iron oxide NPs formed above 0.02 T as indicated by very-small-angle neutron scattering measurements...
October 26, 2016: Nanoscale
Wei-Xu Feng, Arie van der Lee, Yves-Marie Legrand, Eddy Petit, Dan Dumitrescu, Cheng-Yong Su, Mihail Barboiu
The binding and the encapsulation of the 6-aminohexanoic acid (1) and 11-aminoundecanoic acid (2) are achieved in aqueous solution and in crystalline Pyrene-box cages. Unexpectedly, the amino-guanidinium AG(+) and the amino acids 1 or 2 are reacting in aqueous solution in the absence and in the presence of Pyrene-box cages. The formation of an amide bond between a carboxylic acid and the amino-guanidine unit under mild acidic conditions in water without the use a coupling reagent is extremely interesting and unexpected...
October 19, 2016: Organic Letters
Joachim Heinrich, Feng Guo, Mary Jo Trepka
BACKGROUND: Although mercury exposure has been associated with several adverse health effects, the association with childhood asthma is under investigated. Therefore, we explore the association between mercury and childhood asthma in a population with low mercury levels. METHODS: Mercury levels were measured in blood and urine in 1,056 children ages 5-14 years. In addition to including questions about asthma diagnosis and wheezing, the study measured bronchial hyperresponsiveness and allergic sensitization to common aeroallergens...
January 2017: Epidemiology
Stephen B Freedman, Mohamed Eltorki, Linda Chui, Jianling Xie, Sharon Feng, Judy MacDonald, Andrew Dixon, Samina Ali, Marie Louie, Bonita E Lee, Lara Osterreicher, Jennifer Thull-Freedman
OBJECTIVE: To identify the gaps in the care of children infected with Shiga toxin-producing Escherichia coli (STEC), we sought to quantitate care received and management timelines. Such knowledge is crucial to the design of interventions to prevent the development of hemolytic uremic syndrome (HUS). STUDY DESIGN: We conducted a retrospective case-series study of 78 children infected with STEC in Alberta, Canada, through the linkage of microbiology and laboratory results, telephone health advice records, hospital charts, physician billing submissions, and outpatient antimicrobial dispensing databases...
October 10, 2016: Journal of Pediatrics
Chunya Ni, Marie-Sophie Narzt, Ionela-Mariana Nagelreiter, Cheng Feng Zhang, Lionel Larue, Heidemarie Rossiter, Johannes Grillari, Erwin Tschachler, Florian Gruber
Autophagy is a recycling program which allows cells to adapt to metabolic needs and to stress. Defects in autophagy can affect metabolism, aging, proteostasis and inflammation. Autophagy pathway genes, including autophagy related 7 (Atg7), have been associated with the regulation of skin pigmentation, and autophagy defects disturb the biogenesis and transport of melanosomes in melanocytes as well as transfer and processing of melanin into keratinocytes. We have previously shown that mice whose melanocytes or keratinocytes lack Atg7 (and thus autophagy) as a result of specific gene knockout still retained functioning melanosome synthesis and transfer, and displayed only moderate reduction of pigmentation...
October 9, 2016: International Journal of Biochemistry & Cell Biology
Hao Feng, Paula Wu, Marie Leger
Importance: Significant ties exist between clinicians and industry. Little is known about the characteristics of industry payments to dermatologists. Objective: To analyze the nature and extent of industry payments to dermatologists. Design, Setting, and Participants: This was a retrospective review using the publicly available Centers for Medicare and Medicaid Services (CMS) Sunshine Act Open Payment database. Data were downloaded from the publically available CMS website under General Payment and Research Payment data sets...
October 5, 2016: JAMA Dermatology
Feng Wang, Erik Bélanger, Marie-Eve Paquet, Daniel Côté, Yves De Koninck
We have witnessed an accelerated growth of photonics technologies in recent years to enable not only monitoring the activity of specific neurons, while animals are performing certain types of behavior, but also testing whether specific cells, circuits, and regions are sufficient or necessary for initiating, maintaining, or altering this or that behavior. Compared to other sensory systems, however, such as the visual or olfactory system, photonics applications in pain research are only beginning to emerge. One reason pain studies have lagged behind is that many of the techniques originally developed cannot be directly implemented to study key relay sites within pain pathways, such as the skin, dorsal root ganglia, spinal cord, and brainstem...
October 1, 2016: Neuroscience
Kohei Hosokawa, Sachiko Kajigaya, Xingmin Feng, Marie J Desierto, Maria Del Pilar Fernandez Ibanez, Olga Rios, Barbara Weinstein, Phillip Scheinberg, Danielle M Townsley, Neal S Young
Aplastic anemia is an acquired bone marrow disease characterized by marrow hypoplasia, a paucity of hematopoietic stem and progenitor cells, and pancytopenia of the peripheral blood, due to immune attack on the bone marrow. In aplastic anemia, a major challenge is to develop immune biomarkers to monitor the disease. We analyzed circulating miRNAs in plasma samples of aplastic anemia patients in order to identify disease-specific miRNAs. A total of 179 miRNAs were analyzed in 35 plasma samples from 13 aplastic anemia, 11 myelodysplastic syndrome, and 11 healthy controls using the Serum/Plasma Focus microRNA PCR Panel...
September 22, 2016: Haematologica
Jean-François Trempe, Klára Grantz Šašková, Monika Sivá, Colin D H Ratcliffe, Václav Veverka, Annabelle Hoegl, Marie Ménade, Xin Feng, Solomon Shenker, Michal Svoboda, Milan Kožíšek, Jan Konvalinka, Kalle Gehring
The eukaryotic Ddi1 family is defined by a conserved retroviral aspartyl protease-like (RVP) domain found in association with a ubiquitin-like (UBL) domain. Ddi1 from Saccharomyces cerevisiae additionally contains a ubiquitin-associated (UBA) domain. The substrate specificity and role of the protease domain in the biological functions of the Ddi family remain unclear. Yeast Ddi1 has been implicated in the regulation of cell cycle progression, DNA-damage repair, and exocytosis. Here, we investigated the multi-domain structure of yeast Ddi1 using X-ray crystallography, nuclear magnetic resonance, and small-angle X-ray scattering...
2016: Scientific Reports
Xiaodong Yang, John Mudgett, Ghina Bou-About, Marie-France Champy, Hugues Jacobs, Laurent Monassier, Guillaume Pavlovic, Tania Sorg, Yann Herault, Benoit Petit-Demoulière, Ku Lu, Wen Feng, Hongwu Wang, Li-Jun Ma, Roger Askew, Mark D Erion, David E Kelley, Robert W Myers, Cai Li, Hong-Ping Guan
Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2(NI)) and R531G (AMPKγ2(RG)), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2(NI) or AMPKγ2(RG) leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype...
November 4, 2016: Journal of Biological Chemistry
Iris Postmus, Helen R Warren, Stella Trompet, Benoit J Arsenault, Christy L Avery, Joshua C Bis, Daniel I Chasman, Catherine E de Keyser, Harshal A Deshmukh, Daniel S Evans, QiPing Feng, Xiaohui Li, Roelof A J Smit, Albert V Smith, Fangui Sun, Kent D Taylor, Alice M Arnold, Michael R Barnes, Bryan J Barratt, John Betteridge, S Matthijs Boekholdt, Eric Boerwinkle, Brendan M Buckley, Y-D Ida Chen, Anton J M de Craen, Steven R Cummings, Joshua C Denny, Marie Pierre Dubé, Paul N Durrington, Gudny Eiriksdottir, Ian Ford, Xiuqing Guo, Tamara B Harris, Susan R Heckbert, Albert Hofman, G Kees Hovingh, John J P Kastelein, Leonore J Launer, Ching-Ti Liu, Yongmei Liu, Thomas Lumley, Paul M McKeigue, Patricia B Munroe, Andrew Neil, Deborah A Nickerson, Fredrik Nyberg, Eoin O'Brien, Christopher J O'Donnell, Wendy Post, Neil Poulter, Ramachandran S Vasan, Kenneth Rice, Stephen S Rich, Fernando Rivadeneira, Naveed Sattar, Peter Sever, Sue Shaw-Hawkins, Denis C Shields, P Eline Slagboom, Nicholas L Smith, Joshua D Smith, Nona Sotoodehnia, Alice Stanton, David J Stott, Bruno H Stricker, Til Stürmer, André G Uitterlinden, Wei-Qi Wei, Rudi G J Westendorp, Eric A Whitsel, Kerri L Wiggins, Russell A Wilke, Christie M Ballantyne, Helen M Colhoun, L Adrienne Cupples, Oscar H Franco, Vilmundur Gudnason, Graham Hitman, Colin N A Palmer, Bruce M Psaty, Paul M Ridker, Jeanette M Stafford, Charles M Stein, Jean-Claude Tardif, Mark J Caulfield, J Wouter Jukema, Jerome I Rotter, Ronald M Krauss
BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals...
September 1, 2016: Journal of Medical Genetics
Ross G Johnson, Hung C Le, Kristen Evenson, Shelby W Loberg, Tori M Myslajek, Andrea Prabhu, Ann-Marie Manley, Colette O'Shea, Haiying Grunenwald, Madelaine Haddican, Patrick M Fitzgerald, Timothy Robinson, Bruno A Cisterna, Juan C Sáez, Tai-Feng Liu, Dale W Laird, Judson D Sheridan
It is now clear that connexin-based, gap junction "hemichannels" in an undocked state are capable of opening and connecting cytoplasm to the extracellular milieu. Varied studies also suggest that such channel activity plays a vital role in diverse cell processes and abnormal hemichannel activity contributes to pathogenesis. To pursue fundamental questions in this area, investigators require methods for studying hemichannel permeability and dynamics that are quantitative, sensitive, versatile, and available to most cellular and molecular laboratories...
December 2016: Journal of Membrane Biology
Jessica Gagné-Sansfaçon, Geneviève Coulombe, Marie-Josée Langlois, Ariane Langlois, Marilene Paquet, Julie Carrier, Gen-Sheng Feng, Cheng-Kui Qu, Nathalie Rivard
A major risk factor of developing colorectal cancer (CRC) is the presence of chronic inflammation in the colon. In order to understand how inflammation contributes to CRC development, the present study focused on SHP-2, a tyrosine phosphatase encoded by PTPN11 gene in which polymorphisms have been shown to be markers of colitis susceptibility. Conversely, gain-of-function mutations in PTPN11 gene (E76 residue) have been found in certain sporadic CRC. Results shown herein demonstrate that SHP-2 expression was markedly increased in sporadic human adenomas but not in advanced colorectal tumors...
August 25, 2016: Oncotarget
Victor W Wu, Marina A Epelman, Hesheng Wang, H Edwin Romeijn, Mary Feng, Yue Cao, Randall K Ten Haken, Martha M Matuszak
Liver stereotactic body radiation therapy (SBRT) patients differ in both pre-treatment liver function (e.g. due to degree of cirrhosis and/or prior treatment) and radiosensitivity, leading to high variability in potential liver toxicity with similar doses. This work investigates three treatment planning optimization models that minimize risk of toxicity: two consider both voxel-based pre-treatment liver function and local-function-based radiosensitivity with dose; one considers only dose. Each model optimizes different objective functions (varying in complexity of capturing the influence of dose on liver function) subject to the same dose constraints and are tested on 2D synthesized and 3D clinical cases...
September 7, 2016: Physics in Medicine and Biology
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