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JOURNAL ARTICLE
Lin Zeng, Yan-Qing Fu, Ying Gao, Fang Wang, Shuang Liang, Jun-Feng Yin, Marie-Laure Fauconnier, Lijing Ke, Yong-Quan Xu
In this study, widely targeted metabolomics and chemometrics were utilized to comprehensively analyse the formation of taste compounds in Longjing green tea. A total of 580 non-volatile metabolites were identified by using ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry, and alterations in three metabolic pathways were investigated. Notably, the fixation process reduced phosphatidic acid levels, resulting in the formation of lyso-phosphatidylcholine and lyso-phosphatidylethanolamine, as well as the release of esterified polyunsaturated fatty acids...
April 15, 2024: Food Chemistry
#2
JOURNAL ARTICLE
Guangmin Wei, Moon Tay Yue Feng, Zhangyong Si, Mary B Chan-Park
Oral delivery of cells, such as probiotics and vaccines, has proved to be inefficient since cells are generally damaged in an acidic stomach prior to arrival at the intestine to exert their health benefits. In addition, short retention in the intestine is another obstacle which affects inefficiency. To overcome these obstacles, a cell-in-shell structure was designed with pH-responsive and mucoadhesive properties. The pH-responsive shell consisting of three cationic layers of chitosan and three anionic layers of trans -cinnamic acid ( t -CA) was made via layer-by-layer (LbL) assembly...
April 19, 2024: ACS Applied Materials & Interfaces
#3
Ujjayini Ghosh, Eric Tse, Marie Shi, Hyunjun Yang, Feng Wang, Gregory E Merz, Stanley B Prusiner, Daniel R Southworth, Carlo Condello
Down Syndrome (DS) is a common genetic condition caused by trisomy of chromosome 21. Among the complex clinical features including musculoskeletal, neurological and cardiovascular disabilities, individuals with DS develop progressive dementia and early onset Alzheimer's Disease (AD). This is attributed to the increased gene dosage of amyloid precursor protein (APP), the formation of self-propagating Aβ and tau prion conformers, and the deposition of neurotoxic Aβ plaques and tau neurofibrillary tangles...
April 3, 2024: bioRxiv
#4
JOURNAL ARTICLE
Kefang Lai, Dejun Sun, Ranran Dai, Ronnie Samoro, Hae-Sim Park, Annika Åstrand, David Cohen, Maria Jison, Vivian H Shih, Viktoria Werkström, Yuhui Yao, Yajuan Zhang, Wenying Zheng, Nanshan Zhong, Albay Albert, Bo Jianping, Chen Bi, Chen Lijun, Chen Mei, Chen Min, Chen Ping, Chen Zhimin, Chian Chih-Feng, Cho You Sook, Fu Xiuhua, Gao Xiwen, Gu Wei, Han Wei, Han Zhihai, Hu Xi Wei, Huang Kewu, Huang Mao, Isidro Marie Grace Dawn, Jeong Inbeom, Jiang Luning, Jiang Mingyan, Jiang Shanping, Jin Meiling, Kang Jian, Kim Jin Woo, Kim Sang-Ha, Kuang Jiulong, Kuo Ping-Hung, Li Jie, Li Manxiang, Li Minjing, Li Ruoran, Li Wen, Li Xianhua, Li Yanming, Lim Seong Yong, Liu Chuanhe, Liu Chuntao, Liu Jing, Liu Xiaoxia, Lu Huiyu, Luo Zhuang, Ma Shengxi, Mao Liangping, Min Kyung Hoon, Mu Lin, Park Choon-Sik, Park Hae Sim, Park Hye-Kyung, Park Jung-Won, Perng Diahn-Warng, Samoro Ronnie, Shi Guochao, Sun Debin, Sun Dejun, Wang Chun-Hua, Wang Guangfa, Wang Limin, Wang Xuefen, Wang Yan, Wei Liping, Wu Haihong, Xiao Yi, Xiao Zuke, Xie Canmao, Xu Jin-Fu, Xu Xingxiang, Xu Xiyuan, Yan Jianping, Yang Hongzhong, Yoon Ho Joo, Yu Wencheng, Zhang Jin, Zhang Longju, Zhang Min, Zhang Wei, Zhao Jianping, Zhao Ziwen, Zhu Xiaoli, Zhu Yingqun
BACKGROUND: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial. OBJECTIVE: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia. METHODS: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines. Patients aged 12-75 years with severe asthma receiving medium-to-high-dose inhaled corticosteroid/long-acting β2 -agonists, stratified (2:1) by baseline blood eosinophil count (bEOS) (≥300/μL; <300/μL), were randomized (1:1) to benralizumab 30 mg or placebo...
April 1, 2024: Respiratory Medicine
#5
JOURNAL ARTICLE
Federica Pecci, Seshiru Nakazawa, Biagio Ricciuti, Guilherme Harada, Jessica K Lee, Joao V Alessi, Adriana Barrichello, Victor R Vaz, Giuseppe Lamberti, Alessandro Di Federico, Malini M Gandhi, Dimitris Gazgalis, William W Feng, Jie Jiang, Simon Baldacci, Marie-Anais Locquet, Felix H Gottlieb, Monica F Chen, Elinton Lee, Danielle Haradon, Anna Smokovich, Emma Voligny, Tom Nguyen, Vikas K Goel, Zachary Zimmerman, Sumandeep Atwal, Xinan Wang, Magda Bahcall, Rebecca S Heist, Sumaiya Iqbal, Nishant Gandhi, Andrew Elliott, Ari M Vanderwalde, Patrick C Ma, Balazs Halmos, Stephen V Liu, Jianwei Che, Alexa B Schrock, Alexander Drilon, Pasi A Janne, Mark M Awad
Activating point mutations in the MET tyrosine kinase domain (TKD) are oncogenic in a subset of papillary renal cell carcinomas (PRCC). Here, using comprehensive genomic profiling among >600,000 patients, we identify activating MET TKD point mutations as putative oncogenic driver across diverse cancers, with a frequency of ~0.5%. The most common mutations in the MET TKD defined as oncogenic or likely oncogenic according to OncoKB resulted in amino acid substitutions at positions H1094, L1195, F1200, D1228, Y1230, M1250, and others...
April 3, 2024: Cancer Discovery
#6
JOURNAL ARTICLE
Doris Abra Awudi, Anita Nyarkoa Walker, Mary Makhala Weeto, Christiana Babymay Priddy, Otobong Donald Akan, Cynthia Anuseh Baduweh, Bella Abigail Arthur, Salimata Yakubu, Solim Essomandan Clémence Bafei, Timothy Mobolaji Olagunju, Margaret Zaitoun, Yuxia Zhong, Yucong Feng, Yuandie Zhang, Tao Wei, Qing Feng
BACKGROUND: The impact of non-communicable diseases (NCDs) is disproportionately felt by immigrants from low- to medium-income countries (LMICs), partly due to their dietary habits. To thrive in their new environment, migrants either omit or consume certain food items, which could lead to nutritional deficits. As a result, most migrants experience more NCDs than their compatriots in their native countries. Therefore, we evaluated the difference in dietary habits, quality, and the influencing factors of overweight or obesity among African migrant students in Nanjing (China) and non-migrant students in Africa using cross-sectional data...
2024: Frontiers in Nutrition
#7
JOURNAL ARTICLE
Keith Z Sabin, Shiyuan Chen, Eric M Hill, Kyle J Weaver, Jacob Yonke, MaryEllen Kirkman, William B Redwine, Anna M L Klompen, Xia Zhao, Fengli Guo, Mary Cathleen McKinney, Jessica L Dewey, Matthew C Gibson
Bilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development of the larval apical sensory organ in the sea anemone Nematostella vectensis...
March 21, 2024: Developmental Biology
#8
JOURNAL ARTICLE
Bryce J M Bogie, Chelsea Noël, Feng Gu, Sébastien Nadeau, Cecelia Shvetz, Hassan Khan, Marie-Christine Rivard, Stéphane Bouchard, Martin Lepage, Synthia Guimond
BACKGROUND: Schizophrenia is associated with impairments in verbal episodic memory. Strategy for Semantic Association Memory (SESAME) training represents a promising cognitive remediation program to improve verbal episodic memory. Virtual reality (VR) may be a novel tool to increase the ecological validity and transfer of learned skills of traditional cognitive remediation programs. The present proof-of-concept study aimed to assess the feasibility, acceptability, and preliminary efficacy of a VR-based cognitive remediation module inspired by SESAME principles to improve the use of verbal episodic memory strategies in schizophrenia...
June 2024: Schizophrenia Research. Cognition
#9
JOURNAL ARTICLE
Yunhao Tan, Kenta Mosallanejad, Qingxiu Zhang, Stephen O'Brien, Meghan Clements, Stuart Perper, Sarah Wilson, Sudiksha Chaulagain, Jing Wang, Mary Abdalla, Helen Al-Saidi, Danyal Butt, Anca Clabbers, Kwasi Ofori, Beth Dillon, Bohdan Harvey, John Memmott, Christopher Negron, David Winarta, Catherine Tan, Amlan Biswas, Feng Dong, Vanessa Morales-Tirado, Xiaoqing Lu, Gurminder Singh, Michael White, Shanna Ashley, Heather Knight, Susan Westmoreland, Lucy Phillips, Tracy Carr, Lauren Reinke-Breen, Rajeeva Singh, Jianwen Xu, Kan Wu, Lisa Rinaldi, Brian Stoll, Yupeng David He, Lisa Hazelwood, Jozsef Karman, Andrew McCluskey, William Stine, Ivan Correia, Stephen Gauld, Marc C Levesque, Geertruida Veldman, Cedric Hubeau, Timothy Radstake, Ramkrishna Sadhukhan, Edda Fiebiger
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified as a central mechanism for promoting fibrosis downstream of TGFβ. IL11 signaling has recently been reported to promote fibroblast-to-myofibroblast transition, thus leading to various pro-fibrotic phenotypic changes. We confirmed increased mRNA expression of IL11 and IL11Rα in fibrotic diseases by OMICs approaches and in situ hybridization...
2024: Frontiers in Immunology
#10
JOURNAL ARTICLE
Dibyadeep Datta, Isabella Perone, Denethi Wijegunawardana, Feng Liang, Yury M Morozov, Jon Arellano, Alvaro Duque, Zhongcong Xie, Christopher H van Dyck, Mary Kate P Joyce, Amy F T Arnsten
INTRODUCTION: Tau phosphorylated at threonine-217 (pT217-tau) is a novel fluid-based biomarker that predicts onset of Alzheimer's disease (AD) symptoms, but little is known about how pT217-tau arises in the brain, as soluble pT217-tau is dephosphorylated post mortem in humans. METHODS: We used multilabel immunofluorescence and immunoelectron microscopy to examine the subcellular localization of early-stage pT217-tau in entorhinal and prefrontal cortices of aged macaques with naturally occurring tau pathology and assayed pT217-tau levels in plasma...
March 6, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
#11
JOURNAL ARTICLE
Michele Sassano, Monireh Sadat Seyyedsalehi, Giulia Collatuzzo, Claudio Pelucchi, Rossella Bonzi, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Zuo-Feng Zhang, Lizbeth López-Carrillo, Nuno Lunet, Samantha Morais, David Zaridze, Dmitry Maximovich, Vicente Martín, Gemma Castano-Vinyals, Jesús Vioque, Sandra González-Palacios, Mary H Ward, Reza Malekzadeh, Mohammadreza Pakseresht, Raul Ulises Hernández-Ramirez, Malaquias López-Cervantes, Eva Negri, Federica Turati, Charles S Rabkin, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, M Constanza Camargo, Maria Paula Curado, Stefania Boccia, Carlo La Vecchia, Paolo Boffetta
BACKGROUND: Previous studies suggest that dietary vitamin C is inversely associated with gastric cancer (GC), but most of them did not consider intake of fruit and vegetables. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project, a consortium of epidemiological studies on GC. METHODS: Fourteen case-control studies were included in the analysis (5362 cases, 11,497 controls). We estimated odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the association between dietary intake of vitamin C and GC, adjusted for relevant confounders and for intake of fruit and vegetables...
March 4, 2024: Gastric Cancer
#12
JOURNAL ARTICLE
Patrick G Pilie, Virginia Giuliani, Wei-Lien Wang, Daniel J McGrail, Christopher A Bristow, Natalie Y L Ngoi, Keith Kyewalabye, Khalida M Wani, Hung Le, Erick Campbell, Nora S Sánchez, Dong Yang, Jinesh S Gheeya, Rohit Vivek Goswamy, Vijaykumar Holla, Kenna Rael Shaw, Funda Meric-Bernstam, Chiu-Yi Liu, XiaoYan Ma, Ningping Feng, Annette A Machado, Jennifer P Bardenhagen, Christopher P Vellano, Joseph R Marszalek, Eeson Rajendra, Desiree Piscitello, Timothy I Johnson, Maria Likhatcheva, Elias Elinati, Jayesh Majithiya, Joana Neves, Vera Grinkevich, Marco Ranzani, Marina Roy-Luzarraga, Marie Boursier, Lucy Armstrong, Lerin Geo, Giorgia Lillo, Wai Yiu Tse, Alexander J Lazar, Scott E Kopetz, Mary K Geck Do, Sarah Lively, Michael G Johnson, Helen M R Robinson, Graeme C M Smith, Christopher L Carroll, M Emilia Di Francesco, Philip Jones, Timothy P Heffernan, Timothy A Yap
PURPOSE: Mutations in the ATM gene are common in multiple cancers, but clinical studies of therapies targeting ATM aberrant cancers have yielded mixed results. Refinement of ATM loss of function (LOF) as a predictive biomarker of response is urgently needed. EXPERIMENTAL DESIGN: We present the first disclosure and preclinical development of a novel, selective ATR inhibitor, ART0380, and test its antitumor activity in multiple preclinical cancer models. To refine ATM LOF as a predictive biomarker, we performed a comprehensive pan-cancer analysis of ATM variants in patient tumors, and then assessed the ATM variant-to-protein relationship...
February 28, 2024: Clinical Cancer Research
#13
JOURNAL ARTICLE
Mary Lenertz, Qiaobin Li, Zoe Armstrong, Allison Scheiwiller, Gigi Ni, Jien Wang, Li Feng, Austin MacRae, Zhongyu Yang
Biodegradation of insoluble biomass such as cellulose via carbohydrase enzymes is an effective approach to break down plant cell walls and extract valuable materials therein. Yet, the high cost and poor reusability of enzymes are practical concerns. We recently proved that immobilizing multiple digestive enzymes on metal-organic materials (MOMs) allows enzymes to be reused via gravimetric separation, improving the cost efficiency of cereal biomass degradation [ ACS Appl. Mater. Interfaces 2021 , 13 , 36, 43085-43093]...
February 27, 2024: ACS Applied Materials & Interfaces
#14
JOURNAL ARTICLE
Zoe Armstrong, Drew Jordahl, Austin MacRae, Qiaobin Li, Mary Lenertz, Patrick Shen, Anastasiia Botserovska, Li Feng, Angel Ugrinov, Zhongyu Yang
Enzyme immobilization offers a number of advantages that improve biocatalysis; however, finding a proper way to immobilize enzymes is often a challenging task. Implanting enzymes in metal-organic frameworks (MOFs) via co-crystallization, also known as biomineralization, provides enhanced reusability and stability with minimal perturbation and substrate selectivity to the enzyme. Currently, there are limited metal-ligand combinations with a proper protocol guiding the experimental procedures. We have recently explored 10 combinations that allow custom immobilization of enzymes according to enzyme stability and activity in different metals/ligands...
February 5, 2024: Bio-protocol
#15
JOURNAL ARTICLE
Yue Zheng, Baozhan Wang, Ping Gao, Yiyan Yang, Bu Xu, Xiaoquan Su, Daliang Ning, Qing Tao, Qian Li, Feng Zhao, Dazhi Wang, Yao Zhang, Meng Li, Mari-K H Winkler, Anitra E Ingalls, Jizhong Zhou, Chuanlun Zhang, David A Stahl, Jiandong Jiang, Willm Martens-Habbena, Wei Qin
Ammonia-oxidizing archaea (AOA) are among the most ubiquitous and abundant archaea on Earth, widely distributed in marine, terrestrial, and geothermal ecosystems. However, the genomic diversity, biogeography, and evolutionary process of AOA populations in subsurface environments are vastly understudied compared to those in marine and soil systems. Here, we report a novel AOA order Candidatus (Ca.) Nitrosomirales which forms a sister lineage to the thermophilic Ca. Nitrosocaldales. Metagenomic and 16S rRNA gene-read mapping demonstrates the abundant presence of Nitrosomirales AOA in various groundwater environments and their widespread distribution across a range of geothermal, terrestrial, and marine habitats...
January 8, 2024: ISME Journal
#16
JOURNAL ARTICLE
Liping Yang, Timothy P Sheets, Yang Feng, Guojun Yu, Pradip Bajgain, Kuo-Sheng Hsu, Daeho So, Steven Seaman, Jaewon Lee, Ling Lin, Christine N Evans, Mary R Guest, Raj Chari, Brad St Croix
The majority of clinically approved drugs target proteins that are secreted or cell surface bound. However, further advances in this area have been hindered by the challenging nature of receptor deorphanization, as there are still many secreted and cell-bound proteins with unknown binding partners. Here, we developed an advanced screening platform that combines CRISPR-CAS9 guide-mediated gene activation (CRISPRa) and high-avidity bead-based selection. The CRISPRa platform incorporates serial enrichment and flow cytometry-based monitoring, resulting in substantially improved screening sensitivity for well-known yet weak interactions of the checkpoint inhibitor family...
February 16, 2024: Science Advances
#17
JOURNAL ARTICLE
Xuanyu Tao, Zhifeng Yang, Jiajie Feng, Siyang Jian, Yunfeng Yang, Colin T Bates, Gangsheng Wang, Xue Guo, Daliang Ning, Megan L Kempher, Xiao Jun A Liu, Yang Ouyang, Shun Han, Linwei Wu, Yufei Zeng, Jialiang Kuang, Ya Zhang, Xishu Zhou, Zheng Shi, Wei Qin, Jianjun Wang, Mary K Firestone, James M Tiedje, Jizhong Zhou
Unravelling biosphere feedback mechanisms is crucial for predicting the impacts of global warming. Soil priming, an effect of fresh plant-derived carbon (C) on native soil organic carbon (SOC) decomposition, is a key feedback mechanism that could release large amounts of soil C into the atmosphere. However, the impacts of climate warming on soil priming remain elusive. Here, we show that experimental warming accelerates soil priming by 12.7% in a temperate grassland. Warming alters bacterial communities, with 38% of unique active phylotypes detected under warming...
February 8, 2024: Nature Communications
#18
REVIEW
Lin Cheng, Zezhou Feng, Zhaonan Hao, Minmin Si, Rui Yuan, Zhiyuan Feng
OBJECTIVES: The study endeavors to undertake a bibliometric analysis on molar distalization, with the objective of illuminating its evolutionary trajectory, current status, and prognosticating future research hotspots and trends. MATERIAL AND METHODS: A comprehensive exploration of the literature on molar distalization was carried out by conducting a search in the Web of Science (WOS) core database of the University of Hong Kong Electronic Library. The search for topic terms employed included "molar distalization," "molar distalisation," "move molar distally," "molar distal movement," and "molar backwards...
January 30, 2024: Clinical Oral Investigations
#19
JOURNAL ARTICLE
Nhan V Do, Danne C Elbers, Nathanael R Fillmore, Samuel Ajjarapu, Steven J Bergstrom, John Bihn, June K Corrigan, Rupali Dhond, Svitlana Dipietro, Arkadiy Dolgin, Theodore C Feldman, Sergey D Goryachev, Linden B Huhmann, Jennifer La, Paul A Marcantonio, Kyle M McGrath, Stephen J Miller, Vinh Q Nguyen, George R Schneeloch, Feng-Chi Sung, Kaitlin N Swinnerton, Amelia H Tarren, Hannah M Tosi, Danielle Valley, Austin D Vo, Cenk Yildirim, Chunlei Zheng, Robert Zwolinski, Gisele A Sarosy, David Loose, Colleen Shannon, Mary T Brophy
Clinical trial enrollment is impeded by the significant time burden placed on research coordinators screening eligible patients. With 50,000 new cancer cases every year, the Veterans Health Administration (VHA) has made increased access for Veterans to high-quality clinical trials a priority. To aid in this effort, we worked with research coordinators to build the MPACT (Matching Patients to Accelerate Clinical Trials) platform with a goal of improving efficiency in the screening process. MPACT supports both a trial prescreening workflow and a screening workflow, employing Natural Language Processing and Data Science methods to produce reliable phenotypes of trial eligibility criteria...
January 25, 2024: Studies in Health Technology and Informatics
#20
Haojing Duan, Runye Shi, Jujiao Kang, Tobias Banaschewski, Arun L W Bokde, Christian Büchel, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny A Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Sarah Hohmann, Nathalie Holz, Juliane H Fröhner, Michael N Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Xiaolei Lin, Jianfeng Feng
Structural brain aging has demonstrated strong inter-individual heterogeneity and mirroring patterns with brain development. However, due to the lack of large-scale longitudinal neuroimaging studies, most of the existing research focused on the cross-sectional changes of brain aging. In this investigation, we present a data-driven approach that incorporate both cross-sectional changes and longitudinal trajectories of structural brain aging and identified two brain aging patterns among 37,013 healthy participants from UK Biobank...
January 10, 2024: medRxiv
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