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Wei-Xu Feng, Arie van der Lee, Yves-Marie Legrand, Eddy Petit, Dan Dumitrescu, Cheng-Yong Su, Mihail Barboiu
The binding and the encapsulation of the 6-aminohexanoic acid (1) and 11-aminoundecanoic acid (2) are achieved in aqueous solution and in crystalline Pyrene-box cages. Unexpectedly, the amino-guanidinium AG(+) and the amino acids 1 or 2 are reacting in aqueous solution in the absence and in the presence of Pyrene-box cages. The formation of an amide bond between a carboxylic acid and the amino-guanidine unit under mild acidic conditions in water without the use a coupling reagent is extremely interesting and unexpected...
October 19, 2016: Organic Letters
Joachim Heinrich, Guo Feng, Mary Jo Trepka
BACKGROUND: Although mercury exposure has been associated with several adverse health effects, the association with childhood asthma is under-investigated. Therefore, we explore the association between mercury and childhood asthma in a population with low mercury levels. METHODS: Mercury levels were measured in blood and urine in 1,056 children aged 5-14 years. In addition to including questions about asthma diagnosis and wheezing, the study measured bronchial hyper-responsiveness and allergic sensitization to common aeroallergens...
October 6, 2016: Epidemiology
Stephen B Freedman, Mohamed Eltorki, Linda Chui, Jianling Xie, Sharon Feng, Judy MacDonald, Andrew Dixon, Samina Ali, Marie Louie, Bonita E Lee, Lara Osterreicher, Jennifer Thull-Freedman
OBJECTIVE: To identify the gaps in the care of children infected with Shiga toxin-producing Escherichia coli (STEC), we sought to quantitate care received and management timelines. Such knowledge is crucial to the design of interventions to prevent the development of hemolytic uremic syndrome (HUS). STUDY DESIGN: We conducted a retrospective case-series study of 78 children infected with STEC in Alberta, Canada, through the linkage of microbiology and laboratory results, telephone health advice records, hospital charts, physician billing submissions, and outpatient antimicrobial dispensing databases...
October 10, 2016: Journal of Pediatrics
Chunya Ni, Marie-Sophie Narzt, Ionela-Mariana Nagelreiter, Cheng Feng Zhang, Lionel Larue, Heidemarie Rossiter, Johannes Grillari, Erwin Tschachler, Florian Gruber
Autophagy is a recycling program which allows cells to adapt to metabolic needs and to stress. Defects in autophagy can affect metabolism, aging, proteostasis and inflammation. Autophagy pathway genes, including autophagy related 7 (Atg7), have been associated with the regulation of skin pigmentation, and autophagy defects disturb the biogenesis and transport of melanosomes in melanocytes as well as transfer and processing of melanin into keratinocytes. We have previously shown that mice whose melanocytes or keratinocytes lack Atg7 (and thus autophagy) as a result of specific gene knockout still retained functioning melanosome synthesis and transfer, and displayed only moderate reduction of pigmentation...
October 9, 2016: International Journal of Biochemistry & Cell Biology
Hao Feng, Paula Wu, Marie Leger
Importance: Significant ties exist between clinicians and industry. Little is known about the characteristics of industry payments to dermatologists. Objective: To analyze the nature and extent of industry payments to dermatologists. Design, Setting, and Participants: This was a retrospective review using the publicly available Centers for Medicare and Medicaid Services (CMS) Sunshine Act Open Payment database. Data were downloaded from the publically available CMS website under General Payment and Research Payment data sets...
October 5, 2016: JAMA Dermatology
Feng Wang, Erik Bélanger, Marie-Eve Paquet, Daniel Côté, Yves De Koninck
We have witnessed an accelerated growth of photonics technologies in recent years to enable not only monitoring the activity of specific neurons, while animals are performing certain types of behavior, but also testing whether specific cells, circuits, and regions are sufficient or necessary for initiating, maintaining, or altering this or that behavior. Compared to other sensory systems, however, such as the visual or olfactory system, photonics applications in pain research are only beginning to emerge. One reason pain studies have lagged behind is that many of the techniques originally developed cannot be directly implemented to study key relay sites within pain pathways, such as the skin, dorsal root ganglia, spinal cord, and brainstem...
October 1, 2016: Neuroscience
Kohei Hosokawa, Sachiko Kajigaya, Xingmin Feng, Marie J Desierto, Maria Del Pilar Fernandez Ibanez, Olga Rios, Barbara Weinstein, Phillip Scheinberg, Danielle M Townsley, Neal S Young
Aplastic anemia is an acquired bone marrow disease characterized by marrow hypoplasia, a paucity of hematopoietic stem and progenitor cells, and pancytopenia of the peripheral blood, due to immune attack on the bone marrow. In aplastic anemia, a major challenge is to develop immune biomarkers to monitor the disease. We analyzed circulating miRNAs in plasma samples of aplastic anemia patients in order to identify disease-specific miRNAs. A total of 179 miRNAs were analyzed in 35 plasma samples from 13 aplastic anemia, 11 myelodysplastic syndrome, and 11 healthy controls using the Serum/Plasma Focus microRNA PCR Panel...
September 22, 2016: Haematologica
Jean-François Trempe, Klára Grantz Šašková, Monika Sivá, Colin D H Ratcliffe, Václav Veverka, Annabelle Hoegl, Marie Ménade, Xin Feng, Solomon Shenker, Michal Svoboda, Milan Kožíšek, Jan Konvalinka, Kalle Gehring
The eukaryotic Ddi1 family is defined by a conserved retroviral aspartyl protease-like (RVP) domain found in association with a ubiquitin-like (UBL) domain. Ddi1 from Saccharomyces cerevisiae additionally contains a ubiquitin-associated (UBA) domain. The substrate specificity and role of the protease domain in the biological functions of the Ddi family remain unclear. Yeast Ddi1 has been implicated in the regulation of cell cycle progression, DNA-damage repair, and exocytosis. Here, we investigated the multi-domain structure of yeast Ddi1 using X-ray crystallography, nuclear magnetic resonance, and small-angle X-ray scattering...
2016: Scientific Reports
Xiaodong Yang, John Mudgett, Ghina Bou-About, Marie-France Champy, Hugues Jacobs, Laurent Monassier, Guillaume Pavlovic, Tania Sorg, Yann Herault, Benoit Petit-Demouliere, Ku Lu, Wen Feng, Hongwu Wang, Li-Jun Ma, Roger Askew, Mark D Erion, David E Kelley, Robert W Myers, Cai Li, Hong-Ping Guan
Mutations of AMPKγ2 subunit, N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation in humans. Cardiac-specific transgenic overexpression of human AMPKγ2NI or AMPKγ2RG leads to constitutive AMPK activation and the WPW phenotype in mice. However, overexpression of these mutant proteins also caused profound, non-physiological increase in cardiac glycogen, which might abnormally alter the true phenotype...
September 12, 2016: Journal of Biological Chemistry
Iris Postmus, Helen R Warren, Stella Trompet, Benoit J Arsenault, Christy L Avery, Joshua C Bis, Daniel I Chasman, Catherine E de Keyser, Harshal A Deshmukh, Daniel S Evans, QiPing Feng, Xiaohui Li, Roelof A J Smit, Albert V Smith, Fangui Sun, Kent D Taylor, Alice M Arnold, Michael R Barnes, Bryan J Barratt, John Betteridge, S Matthijs Boekholdt, Eric Boerwinkle, Brendan M Buckley, Y-D Ida Chen, Anton J M de Craen, Steven R Cummings, Joshua C Denny, Marie Pierre Dubé, Paul N Durrington, Gudny Eiriksdottir, Ian Ford, Xiuqing Guo, Tamara B Harris, Susan R Heckbert, Albert Hofman, G Kees Hovingh, John J P Kastelein, Leonore J Launer, Ching-Ti Liu, Yongmei Liu, Thomas Lumley, Paul M McKeigue, Patricia B Munroe, Andrew Neil, Deborah A Nickerson, Fredrik Nyberg, Eoin O'Brien, Christopher J O'Donnell, Wendy Post, Neil Poulter, Ramachandran S Vasan, Kenneth Rice, Stephen S Rich, Fernando Rivadeneira, Naveed Sattar, Peter Sever, Sue Shaw-Hawkins, Denis C Shields, P Eline Slagboom, Nicholas L Smith, Joshua D Smith, Nona Sotoodehnia, Alice Stanton, David J Stott, Bruno H Stricker, Til Stürmer, André G Uitterlinden, Wei-Qi Wei, Rudi G J Westendorp, Eric A Whitsel, Kerri L Wiggins, Russell A Wilke, Christie M Ballantyne, Helen M Colhoun, L Adrienne Cupples, Oscar H Franco, Vilmundur Gudnason, Graham Hitman, Colin N A Palmer, Bruce M Psaty, Paul M Ridker, Jeanette M Stafford, Charles M Stein, Jean-Claude Tardif, Mark J Caulfield, J Wouter Jukema, Jerome I Rotter, Ronald M Krauss
BACKGROUND: In addition to lowering low density lipoprotein cholesterol (LDL-C), statin therapy also raises high density lipoprotein cholesterol (HDL-C) levels. Inter-individual variation in HDL-C response to statins may be partially explained by genetic variation. METHODS AND RESULTS: We performed a meta-analysis of genome-wide association studies (GWAS) to identify variants with an effect on statin-induced high density lipoprotein cholesterol (HDL-C) changes. The 123 most promising signals with p<1×10(-4) from the 16 769 statin-treated participants in the first analysis stage were followed up in an independent group of 10 951 statin-treated individuals, providing a total sample size of 27 720 individuals...
September 1, 2016: Journal of Medical Genetics
Ross G Johnson, Hung C Le, Kristen Evenson, Shelby W Loberg, Tori M Myslajek, Andrea Prabhu, Ann-Marie Manley, Colette O'Shea, Haiying Grunenwald, Madelaine Haddican, Patrick M Fitzgerald, Timothy Robinson, Bruno A Cisterna, Juan C Sáez, Tai-Feng Liu, Dale W Laird, Judson D Sheridan
It is now clear that connexin-based, gap junction "hemichannels" in an undocked state are capable of opening and connecting cytoplasm to the extracellular milieu. Varied studies also suggest that such channel activity plays a vital role in diverse cell processes and abnormal hemichannel activity contributes to pathogenesis. To pursue fundamental questions in this area, investigators require methods for studying hemichannel permeability and dynamics that are quantitative, sensitive, versatile, and available to most cellular and molecular laboratories...
September 1, 2016: Journal of Membrane Biology
Jessica Gagné-Sansfaçon, Geneviève Coulombe, Marie-Josée Langlois, Ariane Langlois, Marilene Paquet, Julie Carrier, Gen-Sheng Feng, Cheng-Kui Qu, Nathalie Rivard
A major risk factor of developing colorectal cancer (CRC) is the presence of chronic inflammation in the colon. In order to understand how inflammation contributes to CRC development, the present study focused on SHP-2, a tyrosine phosphatase encoded by PTPN11 gene in which polymorphisms have been shown to be markers of colitis susceptibility. Conversely, gain-of-function mutations in PTPN11 gene (E76 residue) have been found in certain sporadic CRC. Results shown herein demonstrate that SHP-2 expression was markedly increased in sporadic human adenomas but not in advanced colorectal tumors...
August 25, 2016: Oncotarget
Victor W Wu, Marina A Epelman, Hesheng Wang, H Edwin Romeijn, Mary Feng, Yue Cao, Randall K Ten Haken, Martha M Matuszak
Liver stereotactic body radiation therapy (SBRT) patients differ in both pre-treatment liver function (e.g. due to degree of cirrhosis and/or prior treatment) and radiosensitivity, leading to high variability in potential liver toxicity with similar doses. This work investigates three treatment planning optimization models that minimize risk of toxicity: two consider both voxel-based pre-treatment liver function and local-function-based radiosensitivity with dose; one considers only dose. Each model optimizes different objective functions (varying in complexity of capturing the influence of dose on liver function) subject to the same dose constraints and are tested on 2D synthesized and 3D clinical cases...
September 7, 2016: Physics in Medicine and Biology
Shenying Fang, Amaury Vaysse, Myriam Brossard, Yuling Wang, Defeng Deng, Quan Liu, Peter Zhang, Kejing Xu, Ming Li, Runhua Feng, Huey Liu, Yifang Dang, Wei Chen, Victor Prieto, Jeffrey E Gershenwald, Merrick I Ross, Brenna Matejka, Jared Malke, Lauren E Haydu, John D Reveille, Dawen Sui, Roland L Bassett, Nadya Koshkina, Marie Françoise Avril, Mason Lu, Qingyi Wei, Florence Demenais, Christopher I Amos, Jeffrey E Lee
No abstract text is available yet for this article.
August 6, 2016: Journal of Investigative Dermatology
Yu-Erh Huang, Yu-Jie Huang, Mary Ko, Chien-Chin Hsu, Chih-Feng Chen
OBJECTIVE: Granulomatous diseases (GDs) can be metabolically active and indistinguishable from lung cancer on (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) imaging. Evaluation of solitary pulmonary lesions remains a diagnostic challenge in regions with endemic GD. This study sought to determine the efficacy of dual-time-point (DTP) (18)F-FDG PET/computed tomography (CT) imaging in diagnosing solitary pulmonary lesions from such regions. METHODS: A total of 50 patients with solitary pulmonary nodules or masses with confirmed histopathological diagnoses underwent DTP (18)F-FDG PET/CT imaging at 1 and 3 h after tracer injection...
August 4, 2016: Annals of Nuclear Medicine
Laith Alkukhun, Xiao-Feng Wang, Mostafa K Ahmed, Manfred Baumgartner, Marie M Budev, Raed A Dweik, Adriano R Tonelli
BACKGROUND: Pulmonary hypertension (PH) is a common complication of idiopathic pulmonary fibrosis (IPF) that is associated with poor prognosis. Noninvasive screening for PH in IPF patients is challenging and a combination of several noninvasive determinations can improve discrimination. METHODS: We included 235 IPF patients who underwent right heart catheterization (RHC) as part of the lung transplant evaluation. We measured electrocardiographic (ECG) and echocardiographic variables as well as the pulmonary artery (PA) and ascending aorta (AA) diameters on chest CT...
August 2016: Respiratory Medicine
Mary H Wilde, James M McMahon, Eileen Fairbanks, Judith Brasch, Robert Parshall, Feng Zhang, Sarah Miner, Deborah Thayer, Dan Schneiderman, Brian Harrington
PURPOSE: The purpose of this study was to evaluate the feasibility of a new Web-based intermittent catheter self-management intervention. DESIGN: We tested the acceptability and usability of intervention components, which included multiple Web-based materials (an online urinary diary adapted for mobile phone use and an educational booklet), 3 phone calls with a nurse, and a peer-led discussion forum. SUBJECTS AND SETTING: Thirty adults with spinal cord injury using intermittent catheterization for bladder drainage were enrolled; 26 participants received the nurses' phone-based consultations...
September 2016: Journal of Wound, Ostomy, and Continence Nursing
Eli Sapir, Yebin Tao, Felix Feng, Stuart Samuels, Issam El Naqa, Carol A Murdoch-Kinch, Mary Feng, Matthew Schipper, Avraham Eisbruch
OBJECTIVE(S): Dysgeusia is a significant factor reducing quality of life and worsening dysphagia in patients receiving chemoradiation therapy for head and neck cancer. The factors affecting dysgeusia severity are uncertain. We investigated the effects on patient-reported dysgeusia of doses to the oral cavity, salivary output (required to dissolve food particles), and patient-reported xerostomia. METHODS AND MATERIALS: Seventy-three patients with stage III to IV oropharyngeal cancer (OPC) (N=73) receiving definitive intensity modulated radiation therapy concurrently with chemotherapy participated in a prospective, longitudinal study of quality of life (QOL), including assessment of patient-reported gustatory function by taste-related questions from the Head and Neck QOL instrument (HNQOL) and the University of Washington Head and Neck-related QOL instrument (UWQOL), before therapy and periodically after treatment...
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Maria José Garcia-Fernandez, Nicolas Tabary, Feng Chai, Frédéric Cazaux, Nicolas Blanchemain, Marie-Pierre Flament, Bernard Martel
A β-cyclodextrin (β-CD) polymer obtained by crosslinking β-CD with citric acid in its water-insoluble (PCD-I) and soluble (PCD-S) forms was used as a multifunctional direct compression excipient for tablet designing. PCD-I powder was obtained after grinding the solid fraction through a 200μm grid. PCD-S powder was recovered after lyophilization or spray drying of the PCD-S aqueous solutions, eventually followed by a wet granulation step. Both PCD-I and PCD-S powders were characterized, separately and mixed in variable ratios, based on dynamic water vapor sorption, SEM, particle size distribution, tapped density, compressibility, and flowability...
September 25, 2016: International Journal of Pharmaceutics
Xin Feng, Madison K Ramsden, Julie Negri, Mary Grace Baker, Spencer C Payne, Larry Borish, John W Steinke
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) differs from aspirin-tolerant disease in part because of eosinophilic tissue infiltration and overexpression of arachidonic acid metabolic pathway components that lead to enhanced secretion of cysteinyl leukotrienes and prostaglandin (PG) D2 observed constitutively and paradoxically in response to aspirin and other COX inhibitors. We have previously demonstrated the capacity of IFN-γ to drive cysteinyl leukotriene expression and response...
June 14, 2016: Journal of Allergy and Clinical Immunology
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