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https://www.readbyqxmd.com/read/29887699/surgical-management-of-head-and-neck-soft-tissue-sarcoma-11-year-experience-at-a-tertiary-care-centre-in-south-india
#1
Nivedita Sharma, Nebu Abraham George, Rajesh Singh, Elizabeth Mathew Iype, Bipin T Varghese, Shaji Thomas
Head and neck soft tissue sarcoma (HNSTS) is a rare neoplasm accounting for 1% of all head and neck tumours. Because of rarity and varied biological behaviour among various subtypes, knowledge about these tumours is limited. This study aimed at analysing clinicopathological, recurrence and survival pattern of surgically treated HNSTS. Case records of 28 patients of HNSTS who underwent surgery at the Regional Cancer Centre (RCC), Trivandrum (India) between 2002 and 2012 were analysed retrospectively for demographic profile, clinical features, treatment given, recurrence pattern and outcome...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29849960/apatinib-as-targeted-therapy-for-sarcoma
#2
REVIEW
Feng Li, Zhichao Liao, Chao Zhang, Jun Zhao, Ruwei Xing, Sheng Teng, Jin Zhang, Yun Yang, Jilong Yang
Sarcomas are a group of malignant tumors originating from mesenchymal tissue with a variety of cell subtypes. Despite several major treatment breakthroughs, standard treatment using surgery, radiation, and chemotherapy has failed to improve overall survival. Therefore, there is an urgent need to explore new strategies and innovative therapies to further improve the survival rates of patients with sarcomas. Pathological angiogenesis has an important role in the growth and metastasis of tumors. Vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptors (VEGFRs) play a central role in tumor angiogenesis and represent potential targets for anticancer therapy...
May 11, 2018: Oncotarget
https://www.readbyqxmd.com/read/29848420/radiotherapy-outcome-for-pediatric-pelvic-ewing-sarcoma
#3
Saadiya Javed Khan, Ather Kazmi
OBJECTIVE: To evaluate the outcomes of patients undergoing radiotherapy for primary local control of pelvic ewing sarcoma (ES). STUDY DESIGN: Case series. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital, Lahore, from January 2010 to October 2015. METHODOLOGY: Patients with primary pelvic ES were included in the analysis and all other primary disease sites were excluded. All of them were treated with radiotherapy and followed the EuroEwing-99 chemotherapy protocol...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29805371/radiation-associated-angiosarcoma-of-the-breast-a-case-report-and-literature-review
#4
Yung Lyou, Emily Barber, Rita Mehta, Thomas Lee, Wamda Goreal, Ritesh Parajuli
In the last couple of decades, breast conservation therapy, which utilizes a combination of surgery, radiotherapy, and endocrine or chemotherapy, has become the standard of care for treating early-stage breast cancer. This practice has been greatly beneficial in the improvement of the patient's quality of life but has also led to the increased use of radiotherapy and associated soft-tissue sarcomas, with angiosarcoma being the most common malignancy. Radiation-associated angiosarcoma (RAS) of the breast is a rare phenomenon, which has been reported to occur in approximately 0...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29793776/primary-undifferentiated-sarcoma-of-the-meninges-a-case-report-and-comprehensive-review-of-the-literature
#5
REVIEW
Taylor Wapshott, Christine M G Schammel, David P Schammel, Luminita Rezeanu, Michael Lynn
BACKGROUND AND IMPORTANCE: Sarcomas make up 1% of all cases of adult cancer, with 5-10% of those classified as undifferentiated pleomorphic sarcomas (UPS/PUS) and 0.1-4.3% primary intracranial sarcomas. Intracranial undifferentiated sarcoma is characterized by an earlier age of onset and generally poorer prognosis compared to extracranial undifferentiated sarcomas. Current therapies involve surgical excision with wide margins and radiotherapy, with minimal data available regarding the efficacy of chemotherapy...
May 21, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29723407/rationale-and-emerging-strategies-for-immune-checkpoint-blockade-in-soft-tissue-sarcoma
#6
REVIEW
Amy J Wisdom, Yvonne M Mowery, Richard F Riedel, David G Kirsch
Soft tissue sarcomas (STS) are heterogeneous, mesenchymal malignancies with variable biologic behavior. The primary management for localized STS is surgical resection, which may be combined with neoadjuvant or adjuvant radiation therapy to increase the probability of achieving local control. Many patients with large, high-grade STS develop metastatic disease. Several clinical trials of immune checkpoint blockade for STS have produced promising responses in patients with metastatic disease. In this review, recent and ongoing clinical trials of immune checkpoint inhibition for STS are discussed...
May 3, 2018: Cancer
https://www.readbyqxmd.com/read/29714662/safety-of-concurrent-adjuvant-radiotherapy-and-chemotherapy-for-locally-advanced-soft-tissue-sarcoma
#7
Daniela Greto, Mauro Loi, Calogero Saieva, Cristina Muntoni, Camilla Delli Paoli, Carlotta Becherini, Cinzia Ciabatti, Marco Perna, Domenico Campanacci, Francesca Terziani, Giovanni Beltrami, Guido Scoccianti, Pierluigi Bonomo, Icro Meattini, Isacco Desideri, Gabriele Simontacchi, Monica Mangoni, Lorenzo Livi
INTRODUCTION: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS). METHODS: A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29661049/academic-facility-utilization-and-survival-outcomes-in-adult-head-and-neck-sarcomas-an-ncdb-analysis
#8
Richard B Cannon, Patrick S Carpenter, Dustin Boothe, Luke O Buchmann, Jason P Hunt, Shane Lloyd, Ying J Hitchcock, Jeffrey J Houlton, John R Weis, Hailey M Shepherd, Marcus M Monroe
Objectives To investigate clinicopathologic and treatment factors associated with survival in adult head and neck sarcomas in the National Cancer Database (NCDB). To analyze whether treatment settings and therapies received influence survival outcomes and to compare trends in utilization via an aggregated national data set. Study Design Prospectively gathered data. Setting NCDB. Subjects and Methods The study comprised a total of 6944 adult patients treated for a head and neck sarcoma from January 2004 to December 2013...
April 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29626752/efficacy-of-onc201-in-desmoplastic-small-round-cell-tumor
#9
Andrea A Hayes-Jordan, Xiao Ma, Brian A Menegaz, Salah-Eddine Lamhamedi-Cherradi, Charles V Kingsley, Jalen A Benson, Pamela E Camacho, Joseph A Ludwig, Cynthia R Lockworth, Gloria E Garcia, Suzanne L Craig
Desmoplastic Small Round Cell Tumor (DSRCT) is a rare sarcoma tumor of adolescence and young adulthood, which harbors a recurrent chromosomal translocation between the Ewing's sarcoma gene (EWSR1) and the Wilms' tumor suppressor gene (WT1). Patients usually develop multiple abdominal tumors with liver and lymph node metastasis developing later. Survival is poor using a multimodal therapy that includes chemotherapy, radiation and surgical resection, new therapies are needed for better management of DSRCT. Triggering cell apoptosis is the scientific rationale of many cancer therapies...
May 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29582320/soft-tissue-sarcomas-new-opportunity-of-treatment-with-parp-inhibitors
#10
Monica Mangoni, Mariangela Sottili, Giulia Salvatore, Domenico Campanacci, Guido Scoccianti, Giovanni Beltrami, Camilla Delli Paoli, Luca Dominici, Virginia Maragna, Emanuela Olmetto, Icro Meattini, Isacco Desideri, Pierluigi Bonomo, Daniela Greto, Lorenzo Livi
BACKGROUND: Poly(ADP-ribose) polymerases (PARP) are a large family of enzymes involved in several cellular processes, including DNA single-strand break repair via the base-excision repair pathway. PARP inhibitors exert antitumor activity by both catalytic PARP inhibition and PARP-DNA trapping, moreover PARP inhibition represents a potential synthetic lethal approach against cancers with specific DNA-repair defects. Soft tissue sarcoma (STSs) are a heterogeneous group of mesenchymal tumors with locally destructive growth, high risk of recurrence and distant metastasis...
March 26, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29556356/dual-energy-ct-imaging-of-tumor-liposome-delivery-after-gold-nanoparticle-augmented-radiation-therapy
#11
Jeffrey R Ashton, Katherine D Castle, Yi Qi, David G Kirsch, Jennifer L West, Cristian T Badea
Gold nanoparticles (AuNPs) are emerging as promising agents for both cancer therapy and computed tomography (CT) imaging. AuNPs absorb x-rays and subsequently release low-energy, short-range photoelectrons during external beam radiation therapy (RT), increasing the local radiation dose. When AuNPs are near tumor vasculature, the additional radiation dose can lead to increased vascular permeability. This work focuses on understanding how tumor vascular permeability is influenced by AuNP-augmented RT, and how this effect can be used to improve the delivery of nanoparticle chemotherapeutics...
2018: Theranostics
https://www.readbyqxmd.com/read/29552543/cutaneous-angiosarcoma-the-possibility-of-new-treatment-options-especially-for-patients-with-large-primary-tumor
#12
REVIEW
Yasuhiro Fujisawa, Koji Yoshino, Taku Fujimura, Yoshiyuki Nakamura, Naoko Okiyama, Yosuke Ishitsuka, Rei Watanabe, Manabu Fujimoto
The most widely accepted treatment for cutaneous angiosarcoma (CAS) is wide local excision and postoperative radiation to decrease the risk of recurrence. Positive surgical margins and large tumors (T2, >5 cm) are known to be associated with poor prognosis. Moreover, T2 tumors are known to be associated with positive surgical margins. According to previous reports, the majority of CAS patients in Japan had T2 tumors, whereas less than half of the patients in the studies from western countries did so. Consequently, the reported 5-year overall survival of Japanese CAS patients without distant metastasis was only 9%, lower than that for stage-IV melanoma...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29534832/impact-of-oophorectomy-and-hormone-suppression-in-low-grade-endometrial-stromal-sarcoma-a-multicenter-review
#13
L E Stewart, T L Beck, N V Giannakopoulos, M H Rendi, C Isacson, B A Goff
OBJECTIVES: Low grade endometrial stromal sarcoma (LG-ESS) is a rare cancer with an indolent course. We aimed to assess the effectiveness of adjuvant hormonal suppression (HT) with or without oophorectomy (BSO) in prolonging progression free survival (PFS) and overall survival (OS) in patients with LG-ESS. METHODS: We performed a multi-institutional retrospective review of patients treated for low grade LG-ESS from 1985 to 2014. Demographics, treatment and recurrence data were abstracted from medical records...
May 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29502515/radiation-induced-chondrosarcoma-of-the-scapula-after-radiotherapy-for-lung-cancer-a-case-report-and-review-of-the-literature
#14
Abdelfettah Zidane, Adil Arsalane, Mohammed Lahkim, Issam Lalya, Abderrahim Ktaibi, Ismail Essadi
BACKGROUND: Radiotherapy associated with chemotherapy is a well-established treatment modality for locally advanced non-small cell lung cancers. Radiation-induced second malignancies, particularly radiation-induced sarcomas, are rare. Some authors reported a recent increase in the incidence of this rare complication, especially because of the improved prognosis and survival of patients after radiotherapy. Pathogenic mechanisms of radiation-induced sarcomas are poorly understood. However, diagnosis criteria are well established...
March 5, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29471560/knochensarkome
#15
Jendrik Hardes, Georg Gosheger, Timo Budny
Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29413281/secondary-acute-leukemia-in-sarcoma-patients-a-population-based-study
#16
Nina N Sanford, Allison M Martin, Andrew M Brunner, Gregory M Cote, Edwin Choy, Thomas F DeLaney, Ayal A Aizer, Yen-Lin Chen
PURPOSE: To compare rates of secondary acute leukemia between sarcoma patients and the general population, using data from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) registry, and to examine whether various patient, tumor, and treatment factors were associated with development of a secondary acute leukemia. METHODS AND MATERIALS: Patients with a primary diagnosis of connective tissue malignancy between 1973 and 2008 in the SEER database were included...
March 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29355969/primary-liver-sarcomas-in-the-modern-era-resection-or-transplantation
#17
Ioannis T Konstantinidis, Carolijn Nota, Zeljka Jutric, Philip Ituarte, Warren Chow, Peiguo Chu, Gagandeep Singh, Susanne G Warner, Laleh G Melstrom, Yuman Fong
BACKGROUND AND OBJECTIVES: Primary liver sarcomas (PLS) are rare. Published series are limited by small numbers of patients. METHODS: We reviewed the National Cancer Database (2004-2014) for patients who underwent surgical resection of PLS. RESULTS: Of 237 patients identified, the majority were female (60.8%), with median age of 52 years. Histologies were: epithelioid hemangioendothelioma (n = 67), angiosarcoma (n = 64), leiomyosarcoma (n = 33), embryonal rhabdomyosarcoma (n = 31), carcinosarcoma (n = 16), giant cell sarcoma (n = 14), spindle cell sarcoma (n = 12)...
January 22, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29220723/gold-nanoparticles-enhance-radiation-sensitization-and-suppress-colony-formation-in-a-feline-injection-site-sarcoma-cell-line-in-vitro
#18
J Z Benton, R J Williams, A Patel, K Meichner, J Tarigo, K Nagata, T D Pethel, R M Gogal
Injection Site Sarcomas (ISS) are highly invasive feline malignant tumors that are frequently associated with routine vaccination. Current treatment modalities include chemotherapy, radiation, and radical surgery. ISS have been shown to be one of the most treatment resistant of feline cancers with high rates of recurrence. Previous studies have shown that gold and other high atomic number nanoparticles have the ability to increase the dose of radiation deposited into tissue by generating secondary electrons...
April 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29211310/presentation-and-outcome-of-frequent-and-rare-sarcoma-histologic-subtypes-a-study-of-10-262-patients-with-localized-visceral-soft-tissue-sarcoma-managed-in-reference-centers
#19
Nicolas Penel, Jean-Michel Coindre, Antoine Giraud, Philippe Terrier, Dominique Ranchere-Vince, Françoise Collin, Sophie L E Guellec, Céline Bazille, Marick Lae, Gonzague de Pinieux, Isabelle L Ray-Coquard, Sylvie Bonvalot, Axel L E Cesne, Yves-Marie Robin, Eberhardt Stoeckle, Maud Toulmonde, Jean-Yves Blay
BACKGROUND: The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODS: The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled in the "Conticabase." Diagnoses were systematically reviewed by expert pathologists, and entities were classified according to the 2013 World Health Organization classification...
March 15, 2018: Cancer
https://www.readbyqxmd.com/read/29198676/case-report-primary-de-novo-sarcoma-in-transplant-pancreas-allograft
#20
S Nagaraju, S J Grethlein, S Vaishnav, A A Sharfuddin, J A Powelson, J A Fridell
BACKGROUND: The majority of malignancies after transplantation appear to be virally mediated and of recipient origin. Donor-derived neoplasms occur early, whereas recipient-origin tumors typically occur many years after transplantation. Sarcomas are a relatively rare form of cancer. The etiology of sarcomas remains largely unknown, although some are linked to viruses, familial cancer syndromes, or therapeutic radiation exposure. Primary sarcomas are extremely rare, accounting for <0...
December 2017: Transplantation Proceedings
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