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Stroke , ischemic stroke , intracerebral

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https://www.readbyqxmd.com/read/28333925/video-based-educational-intervention-associated-with-improved-stroke-literacy-self-efficacy-and-patient-satisfaction
#1
Mary Carter Denny, Farhaan Vahidy, Kim Y T Vu, Anjail Z Sharrief, Sean I Savitz
BACKGROUND AND PURPOSE: Interventions are needed to improve stroke literacy among recent stroke survivors. We developed an educational video for patients hospitalized with acute ischemic stroke (AIS) and intracerebral hemorrhage (ICH). METHODS: A 5-minute stroke education video was shown to our AIS and ICH patients admitted from March to June 2015. Demographics and a 5-minute protocol Montreal Cognitive Assessment were also collected. Questions related to stroke knowledge, self-efficacy, and patient satisfaction were answered before, immediately after, and 30 days after the video...
2017: PloS One
https://www.readbyqxmd.com/read/28325378/-epidemiology-of-strokes-in-pediatry
#2
Yannick Béjot, Benoit Delpont, Christelle Blanc, Véronique Darmency, Frédéric Huet, Maurice Giroud
Incidence of perinatal arterial stroke (ischemic stroke, intracerebral hemorrhage and subarachnoid hemorrhage) occurring between 20 weeks of gestation and postnatal day 28 ranges between 20 and 65 cases per 100,000 living births. In children aged 29 days to 18 years old, the total incidence is 1.3 to 4.3 for 100,000 per year. In France, almost 450 children are hospitalized for a stroke each year, among them approximately half have an intracerebral hemorrhage.
March 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28324263/decannulation-and-functional-outcome-after-tracheostomy-in-patients-with-severe-stroke-decast-a-prospective-observational-study
#3
Hauke Schneider, Franziska Hertel, Matthias Kuhn, Maximilian Ragaller, Birgit Gottschlich, Anne Trabitzsch, Markus Dengl, Marcus Neudert, Heinz Reichmann, Sigrid Wöpking
BACKGROUND: Tracheostomy is performed in ventilated stroke patients affected by persisting severe dysphagia, reduced level of consciousness, or prolonged mechanical ventilation. The study aim was to determine the frequency and predictors of successful decannulation and long-term functional outcome in tracheotomized stroke patients. METHODS: A prospective single-center observational study recruited ventilated patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage...
March 21, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28303501/isoflurane-postconditioning-inhibits-tpa-induced-matrix-metalloproteinases-activation-after-hypoxic-injury-via-low-density-lipoprotein-receptor-related-protein-and-extracellular-signal-regulated-kinase-pathway
#4
So Yeon Kim, So Yeong Cheon, Eun Jung Kim, Jae Hoon Lee, Eun Hee Kam, Jeong Min Kim, Miran Park, Bon-Nyeo Koo
Tissue plasminogen activator (tPA) is the only recommended pharmacological treatment for acute ischemic stroke. However, tPA can induce intracerebral hemorrhage by blood-brain barrier breakdown through an increase in matrix metalloproteinases (MMPs). Previously, we showed that isoflurane postconditioning reduced intracranial hemorrhage following tPA treatment after cerebral ischemia. Here, we investigated the mechanism by which isoflurane postconditioning reduces tPA-induced MMP-2 and MMP-9 activation following hypoxia/reoxygenation (H/R) in brain endothelial cells...
March 16, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28303440/the-efficacy-and-safety-of-high-dose-statins-in-acute-phase-of-ischemic-stroke-and-transient-ischemic-attack-a-systematic-review
#5
Jing-Xue Fang, Er-Qiang Wang, Wei Wang, Yang Liu, Gang Cheng
Inconsistent findings in the studies have been observed concerning the higher dose of statins use in the acute phase of ischemic stroke and transient ischemic attack (TIA). Therefore, we performed a systematic review to assess this issue. A computerized literature search in PubMed, Cochrane Library databases, and EMBASE for randomized controlled trials (RCTs) was conducted. The efficacy outcome indicators were National Institutes of Health Stroke Scale (NIHSS) score, infarct volume, and recurrence of stroke; the safety outcome indicators were intracranial hemorrhage events, cardiovascular and cerebrovascular events, and all-cause death...
March 16, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28294063/cerebral-microbleeds-do-not-predict-hemorrhagic-transformation-in-acute-ischemic-stroke-patients-with-atrial-fibrillation-and-or-rheumatic-heart-disease
#6
Junfeng Liu, Deren Wang, Jie Li, Jing Lin, Yao Xiong, Bian Liu, Chenchen Wei, Bo Wu, Zhenxing Ma, Shihong Zhang, Ming Liu
Background and Purpose Cerebral microbleeds (CMBs) are known to be potential risk factors for intracerebral hemorrhage (ICH), but there is controversy on the relationship between CMBs and hemorrhagic transformation (HT) after ischemic stroke. Besides, the question regarding whether the relationship between CMBs and HT can be affected by antithrombotic drugs in acute stage of ischemic stroke has not yet reached a consensus. Methods 174 acute ischemic stroke patients with atrial fibrillation (AF) and/or rheumatic heart disease (RHD) were prospectively and consecutively enrolled in the study, of which 160 patients (mean 68...
March 13, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28289240/pais-2-paracetamol-acetaminophen-in-stroke-2-results-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#7
Inger R de Ridder, Heleen M den Hertog, H Maarten A van Gemert, A H C M L Tobien Schreuder, Annemieke Ruitenberg, E Lisette Maasland, Ritu Saxena, Jordie H van Tuijl, Ben P W Jansen, Renske M Van den Berg-Vos, Frederique Vermeij, Peter J Koudstaal, L Jaap Kappelle, Ale Algra, H Bart van der Worp, Diederik W J Dippel
BACKGROUND AND PURPOSE: Subfebrile body temperature and fever in the first days after stroke are strongly associated with unfavorable outcome. A subgroup analysis of a previous trial suggested that early treatment with paracetamol may improve functional outcome in patients with acute stroke and a body temperature of ≥36.5°C. In the present trial, we aimed to confirm this finding. METHODS: PAIS 2 (Paracetamol [Acetaminophen] in Stroke 2) was a multicenter, randomized, double-blind, placebo-controlled clinical trial...
March 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28279192/stroke-alters-behavior-of-human-skin-derived-neural-progenitors-after-transplantation-adjacent-to-neurogenic-area-in-rat-brain
#8
Carlos de la Rosa-Prieto, Cecilia Laterza, Ana Gonzalez-Ramos, Somsak Wattananit, Ruimin Ge, Olle Lindvall, Daniel Tornero, Zaal Kokaia
BACKGROUND: Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cells, their proliferation, migration, differentiation, and function is only partly understood. METHODS: Here we have assessed the influence of the stroke-induced injury on grafts of human skin iPSCs-derived long-term neuroepithelial-like stem cells using transplantation into the rostral migratory stream (RMS), adjacent to the neurogenic subventricular zone, in adult rats as a model system...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28277460/aspects-ct-in-acute-ischemia-review-of-current-data
#9
Supada Prakkamakul, Albert J Yoo
The Alberta Stroke Program Early CT score (ASPECTS) is a 10-point semiquantitative topographic scoring system developed for the assessment of early ischemic changes (EICs) on noncontrast-enhanced computed tomography (NCCT) in patients with acute ischemic stroke involving the middle cerebral artery (MCA) territory. One point is subtracted from a total score of 10, if an EIC is present in any part of each of the ASPECTS regions. Higher ASPECTS has been associated with better outcomes and a lower risk of symptomatic intracerebral hemorrhage...
March 8, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28275198/temporal-trends-in-sex-differences-with-regard-to-stroke-incidence-the-dijon-stroke-registry-1987-2012
#10
Marie Giroud, Benoit Delpont, Benoit Daubail, Christelle Blanc, Jérôme Durier, Maurice Giroud, Yannick Béjot
BACKGROUND AND PURPOSE: We evaluated temporal trends in stroke incidence between men and women to determine whether changes in the distribution of vascular risk factors have influenced sex differences in stroke epidemiology. METHODS: Patients with first-ever stroke including ischemic stroke, spontaneous intracerebral hemorrhage, subarachnoid hemorrhage, and undetermined stroke between 1987 and 2012 were identified through the population-based registry of Dijon, France...
March 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28268349/characterization-of-thrombus-stiffening-in-radio-frequency-rf-mechanical-thrombectomy
#11
Chris C H Chon, Jack Z Qin, John C K Kwok, David C C Lam
Intra-arterial mechanical thrombectomy (IAMT) for ischemic stroke has high recanalization rate, long treatment time window and low risk of symptomatic intracerebral haemorrhage (sICH), but thrombus fragments produced during treatment can lead to distal embolization. Fragmentation can be reduced if the thrombus is strengthened by increasing the thrombus's crosslink density. Radio frequency (rf) electric current commonly used in surgery to cut and coagulate tissue can induce crosslinking in thrombus. The increase in thrombus stiffness as a result of the increase in crosslinking from rf treatment is characterized in this study...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258258/association-between-acute-kidney-disease-and-intravenous-dye-administration-in-patients-with-acute-stroke-a-population-based-study
#12
Stacie L Demel, Aaron W Grossman, Jane C Khoury, Charles J Moomaw, Kathleen Alwell, Brett M Kissela, Daniel Woo, Matthew L Flaherty, Simona Ferioli, Jason Mackey, Felipe De Los Rios la Rosa, Sharyl Martini, Opeolu Adeoye, Dawn O Kleindorfer
BACKGROUND AND PURPOSE: Computed tomographic angiography and conventional angiography provide timely vascular anatomic information in patients with stroke. However, iodinated contrast dye may cause acute kidney injury (AKI). Within a large, biracial population, we examined in-hospital incidence of new or worsening kidney disease in patients with stroke and its association with administration of intravenous dye. METHODS: All adult residents of the Greater Cincinnati/Northern Kentucky region with acute ischemic stroke or intracerebral hemorrhage who presented to an emergency department in 2010 were included...
March 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28258253/quality-of-acute-care-and-long-term-quality-of-life-and-survival-the-australian-stroke-clinical-registry
#13
Dominique A Cadilhac, Nadine E Andrew, Natasha A Lannin, Sandy Middleton, Christopher R Levi, Helen M Dewey, Brenda Grabsch, Steve Faux, Kelvin Hill, Rohan Grimley, Andrew Wong, Arman Sabet, Ernest Butler, Christopher F Bladin, Timothy R Bates, Patrick Groot, Helen Castley, Geoffrey A Donnan, Craig S Anderson
BACKGROUND AND PURPOSE: Uncertainty exists over whether quality improvement strategies translate into better health-related quality of life (HRQoL) and survival after acute stroke. We aimed to determine the association of best practice recommended interventions and outcomes after stroke. METHODS: Data are from the Australian Stroke Clinical Registry during 2010 to 2014. Multivariable regression was used to determine associations between 3 interventions: received acute stroke unit (ASU) care and in various combinations with prescribed antihypertensive medication at discharge, provision of a discharge care plan, and outcomes of survival and HRQoL (EuroQoL 5-dimensional questionnaire visual analogue scale) at 180 days, by stroke type...
March 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28257893/post-stroke-treatment-with-17%C3%AE-estradiol-exerts-neuroprotective-effects-in-both-normotensive-and-hypertensive-rats
#14
Wendy Stoop, Deborah De Geyter, Sofie Verachtert, Sofie Brouwers, Peggy Verdood, Jacques De Keyser, Ron Kooijman
Although ischemic stroke is a major cause of death worldwide and the predominant cause of acquired disability, the only effective drug therapy that has been developed thus far is reperfusion by tissue plasminogen activator. Since most patients do not qualify for this treatment, new methods have to be developed. It is well known that estradiol (E2) exerts neuroprotective effects in different models of cerebral ischemia, but post-stroke treatment after an acute stroke has hardly been investigated. As many patients with an acute ischemic stroke have arterial hypertension, it is also of interest to evaluate the influence of this co-morbidity on the treatment efficacy of E2...
February 28, 2017: Neuroscience
https://www.readbyqxmd.com/read/28254179/neutrophil-counts-and-initial-presentation-of-12-cardiovascular-diseases-a-caliber-cohort%C3%A2-study
#15
Anoop Dinesh Shah, Spiros Denaxas, Owen Nicholas, Aroon D Hingorani, Harry Hemingway
BACKGROUND: Neutrophil counts are a ubiquitous measure of inflammation, but previous studies on their association with cardiovascular disease (CVD) were limited by small numbers of patients or a narrow range of endpoints. OBJECTIVES: This study investigated associations of clinically recorded neutrophil counts with initial presentation for a range of CVDs. METHODS: We used linked primary care, hospitalization, disease registry, and mortality data in England...
March 7, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28250731/blood-micrornas-as-potential-diagnostic-markers-for-hemorrhagic-stroke
#16
REVIEW
Bridget Martinez, Philip V Peplow
Proper medical treatment of a stroke victim relies on accurate and rapid differentiation between ischemic and hemorrhagic stroke, which in current practice is performed by computerized tomography (CT) or magnetic resonance imaging (MRI) scans. A panel of microRNAs could be an extremely useful clinical tool for distinguishing between hemorrhagic and ischemic stroke. This review has shown that blood miRNA profile can distinguish hemorrhagic from ischemic stroke in patients and in experimental animal models. It also seems likely they can differentiate between intracerebral and subarachnoid hemorrhage stroke...
January 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28243503/hemorrhagic-primary-cns-angiitis-and-vasoconstrictive-drug-exposure
#17
Mehmet A Topcuoglu, Ruchira M Jha, Jacob George, Matthew P Frosch, Aneesh B Singhal
BACKGROUND: Primary angiitis of the CNS (PACNS) typically manifests with accumulating neurologic deficits from ischemic strokes. Intracerebral hemorrhage (ICH) is an uncommon complication. There is limited knowledge about the risk factors and features of hemorrhagic PACNS. METHODS: We identified 49 patients (20 biopsy-proven) with PACNS diagnosed at our hospital from 1993 to 2015. We compared the features of hemorrhagic and nonhemorrhagic PACNS and analyzed the hemorrhagic PACNS cases in detail...
February 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/28242247/recurrent-pregnancy-loss-and-cardiovascular-disease-mortality-in-japanese-women-a-population-based-prospective-cohort-study
#18
Keiko Yamada, Hiroyasu Iso, Renzhe Cui, Akiko Tamakoshi
BACKGROUND: This study aimed to examine the association between recurrent pregnancy loss and the risk of cardiovascular disease mortality. METHODS: We identified 54,652 women who were pregnant during the Japan Collaborative Cohort Study. These women were 40-79 years at the date of cohort entry between 1988 and 1990. Participants received municipal health screening examinations and completed self-administered questionnaires. The cause of death was confirmed by annual or biannual follow-up surveys for a median of 18 years...
February 24, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28242081/long-term-risk-of-ischemic-stroke-after-the-cox-maze-iii-procedure-for-atrial-fibrillation
#19
Anders Albåge, Ulrik Sartipy, Göran Kennebäck, Birgitta Johansson, Henrik Scherstén, Lena Jidéus
BACKGROUND: The long-term risk of stroke after surgical treatment of atrial fibrillation is not well known. We performed an observational cohort study with long follow-up after the "cut-and-sew" Cox-maze III procedure (CM-III), including left atrial appendage excision. The aim was to analyze the incidence of stroke/transient ischemic attack (TIA) and the association to preoperative CHA2DS2-VASc (age in years, sex, congestive heart failure history, hypertension history, stroke/TIA, thromboembolism history, vascular disease history, diabetes mellitus) score...
February 24, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28241749/development-and-validation-of-a-score-for-evaluating-comprehensive-stroke-care-capabilities-j-aspect-study
#20
Akiko Kada, Kunihiro Nishimura, Jyoji Nakagawara, Kuniaki Ogasawara, Junichi Ono, Yoshiaki Shiokawa, Toru Aruga, Shigeru Miyachi, Izumi Nagata, Kazunori Toyoda, Shinya Matsuda, Akifumi Suzuki, Hiroharu Kataoka, Fumiaki Nakamura, Satoru Kamitani, Koji Iihara
BACKGROUND: Although the Brain Attack Coalition recommended establishing centers of comprehensive care for stroke and cerebrovascular disease patients, a scoring system for such centers was lacking. We created and validated a comprehensive stroke center (CSC) score, adapted to Japanese circumstances. METHODS: Of the selected 1369 certified training institutions in Japan, 749 completed an acute stroke care capabilities survey. Hospital performance was determined using a 25-item score, evaluating 5 subcategories: personnel, diagnostic techniques, specific expertise, infrastructure, and education...
February 28, 2017: BMC Neurology
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