Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Jiayi Li, Yiming Zheng, Yawen Zhao, Kang Qi, Gang Lin, Ran Liu, Hongjun Hao, Zhaoxia Wang, Yun Yuan, Feng Gao
BACKGROUND: Coronavirus disease 2019 (COVID-19) has been a great concern since 2019. Patients with myasthenia gravis (MG) may be at higher risk of COVID-19 and a more severe disease course. We examined the associations between COVID-19 and MG. METHODS: This single-center retrospective cohort study involved 134 patients who were diagnosed with MG from June 2020 to November 2022 and followed up until April 2023. They were divided into a COVID-19 group and non-COVID-19 group...
April 23, 2024: Neurological Sciences
#2
JOURNAL ARTICLE
Rei Murakami, Hirotaka Watanabe, Hideko Hashimoto, Mayu Kashiwagi-Hakozaki, Tadafumi Hashimoto, Celeste M Karch, Takeshi Iwatsubo, Hideyuki Okano
Genetic variants in the apolipoprotein E ( APOE ) gene affect the onset and progression of Alzheimer's disease (AD). The APOE Christchurch ( APOE Ch) variant has been identified as the most prominent candidate for preventing the onset and progression of AD. In this study, we generated isogenic APOE3 Ch/ 3 Ch human induced pluripotent stem cells (iPSCs) from APOE3 / 3 healthy control female iPSCs and induced them into astrocytes. RNA expression analysis revealed the inherent resilience of APOE3 Ch/ 3 Ch astrocytes to induce a reactive state in response to inflammatory cytokines...
April 22, 2024: Journal of Neuroscience
#3
JOURNAL ARTICLE
Shahriyar Shahbazi Khamas, Yoni Van Dijk, Mahmoud I Abdel-Aziz, Anne H Neerincx, Jelle Blankestijn, Susanne J H Vijverberg, Simone Hashimoto, Andrew Bush, Aletta D Kraneveld, Anna M Hedman, Antoaneta A Toncheva, Catarina Almqvist, Christine Wolff, Clare S Murray, Gunilla Hedlin, Graham Roberts, Ian M Adcock, Javier Korta-Murua, Klaus Bønnelykke, Louise J Fleming, Maria Pino-Yanes, Mario Gorenjak, Michael Kabesch, Olaia Sardón-Prado, Paolo Montuschi, Florian Singer, Paula Corcuera-Elosegui, Stephen J Fowler, Susanne Brandstetter, Susanne Harner, Sven-Erik Dahlén, Uroš Potočnik, Urs Frey, Wim van Aalderen, Paul Brinkman, Anke H Maitland-van der Zee
RATIONALE: Early identification of children with poorly controlled asthma is imperative for optimizing treatment strategies. The analysis of exhaled volatile organic compounds (VOCs) is an emerging approach to identify prognostic and diagnostic biomarkers in pediatric asthma. OBJECTIVES: To assess the accuracy of gas chromatography-mass spectrometry based exhaled metabolite analysis to differentiate between controlled and uncontrolled pediatric asthma. METHODS: This study encompassed a discovery (SysPharmPediA) and validation phase (U-BIOPRED, PANDA)...
April 22, 2024: American Journal of Respiratory and Critical Care Medicine
#4
JOURNAL ARTICLE
Misaki Endo, Miki Ono, Ayaka Deguchi, Yoshio Iwata, Yu Tamada, Jiro Masuya, Hajime Tanabe, Naoki Hashimoto, Takeshi Inoue, Mina Honyashiki
BACKGROUND: Subjective social status influences anxiety, but at present, the mechanism is not fully understood. It has been reported that negative childhood experiences, such as abuse, can influence depressive symptoms through subjective social status and personality traits, such as self-esteem. A similar mechanism is presumed to underlie anxiety symptoms in adulthood. Therefore, we hypothesized that subjective social status and self-esteem are intermediate factors in the indirect effects of childhood abuse on state anxiety in adulthood, and analyzed the indirect effects via these factors using a path analysis...
2024: Neuropsychiatric Disease and Treatment
#5
JOURNAL ARTICLE
Ilaria Stramazzo, Giorgio Mangino, Silvia Capriello, Giovanna Romeo, Silvia Martina Ferrari, Poupak Fallahi, Maria Flavia Bagaglini, Marco Centanni, Camilla Virili
BACKGROUND: CD20+ T cells represent up to 5% of circulating T lymphocytes. These cells have been shown to produce higher levels of IL-17A and IFN-γ than those of CD20- T lymphocytes. Some reports described the role of CD20+ T cells in autoimmune disorders such as multiple sclerosis and rheumatoid arthritis possibly due to their ability to produce these inflammatory cytokines. This study is aimed at describing the behavior of CD20+ T lymphocytes in the most frequent autoimmune disorder, i...
April 20, 2024: Journal of Endocrinological Investigation
#6
JOURNAL ARTICLE
Hiroki Futatsusako, Rina Hashimoto, Masaki Yamamoto, Jumpei Ito, Yasufumi Matsumura, Hajime Yoshifuji, Kotaro Shirakawa, Akifumi Takaori-Kondo, Kei Sato, Miki Nagao, Kazuo Takayama
A primary reason for the ongoing spread of coronavirus disease 2019 (COVID-19) is the continuous acquisition of mutations by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanism of acquiring mutations is not fully understood. In this study, we isolated SARS-CoV-2 from an immunocompromized patient persistently infected with Omicron strain BF.5 for approximately 4 months to analyze its genome and evaluate drug resistance. Although the patient was administered the antiviral drug remdesivir (RDV), there were no acquired mutations in RDV binding site, and all isolates exhibited susceptibility to RDV...
May 17, 2024: IScience
#7
Martina Cicia, Giampaolo Papi, Alfredo Scillitani, Stefania Corrado, Pietro Locantore, Alfredo Pontecorvi
Parathyroid carcinoma (PC) is a rare endocrine neoplasm that typically presents with osteopenia/osteoporosis, nephrolithiasis, asthenia, and neuropsychiatric symptoms. We describe the case of a 48-year-old woman, presenting with a large painful hematoma in the cervicomediastinal area. The neck ultrasound (US) demonstrated a solid lesion measuring 40 × 80 × 55 mm, markedly hypoechoic, which extended from the right thyroid lobe to the mediastinum. The blood tests showed elevated serum calcium and parathyroid hormone (PTH) concentrations, consistent with hypercalcemic primary hyperparathyroidism...
April 2024: JCEM Case Rep
#8
JOURNAL ARTICLE
Motonori Hashimoto, Takashi Hirai, Kenichiro Sakai, Kentaro Yamada, Kentaro Sakaeda, Jun Hashimoto, Satoru Egawa, Shingo Morishita, Yu Matsukura, Hiroyuki Inose, Yutaka Kobayashi, Hiroaki Onuma, Kyohei Sakaki, Masaki Tomori, Ichiro Torigoe, Miharu Ochi, Hiroki Ishiguro, Satoshi Tamura, Shuta Ushio, Tsuyoshi Yamada, Norihiko Miyake, Kazuo Kusano, Kazuyuki Otani, Shigeo Shindo, Yoshiyasu Arai, Atsushi Okawa, Toshitaka Yoshii
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To compare the frequency of complications and outcomes between patients with ossification of the posterior longitudinal ligament (OPLL) of the cervical spine and those with cervical spondylotic myelopathy (CSM) who underwent anterior surgery. SUMMARY OF BACKGROUND DATA: Anterior cervical spine surgery for OPLL is an effective surgical procedure; however, it is complex and technically demanding compared with the procedure for CSM...
April 19, 2024: Clinical Spine Surgery
#9
JOURNAL ARTICLE
Wolfgang J Schnedl, Simon Michaelis, Harald Mangge, Dietmar Enko
PURPOSE: Recommended pharmacotherapy for hypothyroidism in Hashimoto's thyroiditis (HT) is oral supplementation with levothyroxine (LT-4). However, serum thyrotropin (TSH) levels within normal range are not consistently achieved with LT-4 medication. PATIENTS AND METHODS: We report on 35 HT patients with LT-4 therapy in this retrospective evaluation. In general, we recommend that a maximum of two sips of water, which would then amount to < 50 mL, be ingested at the same time as LT-4...
April 18, 2024: Endocrine
#10
JOURNAL ARTICLE
Michinori Matsuoka, Ayumi Kobayashi, Misa Matsuoka, Yayoi Honda, Riri Hashimoto, Yukako Sasaki, Tsutomu Kakuda, Yasunori Suzuki, Shinji Takai
To investigate the etiological role of vapB-positive Rhodococcus equi in pigs, R. equi was isolated from the submaxillary lymph nodes with or without macroscopically detectable lesions of apparently healthy growing-finishing pigs at a slaughterhouse in Toyama Prefecture, Japan. R. equi was isolated from 57 (24.6%) of 232 pigs with macroscopically detectable lymph node lesions, and 56 (98.2%) of the 57 isolates were vapB-positive. R. equi was isolated from 10 (2.4%) of 420 pigs without lymph node lesions, and six (60%) of the 10 isolates were vapB-positive...
April 16, 2024: Journal of Veterinary Medical Science
#11
JOURNAL ARTICLE
Naoki Kosaka, Takanori Uchiyama, Masahiro Onozawa, Jun Nagai, Jiro Koya, Suguru Ishizaka, Toshiyuki Nagai, Yohei Ikebe, Kenjiro Kato, Zen-Ichi Tanei, Jun Sakakibara-Konishi, Yuta Hasegawa, Hiroyuki Ohigashi, Hideki Goto, Daigo Hashimoto, Hideki Ujiie, Satoshi Hirano, Satoshi Konno, Toshihisa Anzai, Koji Taniguchi, Shinya Tanaka, Takanori Teshima
We herein present a fatal case of constrictive pericarditis (CP) due to acute myelomonocytic leukemia (AMML) in a patient who initially complained of an acute onset of chest pain two days after COVID-19 vaccination. An autopsy revealed pericardial infiltration of leukemic cells. CP is rarely associated with leukemia and only 14 cases have been reported in the literature. The etiology of CP in previous reports included leukemic infiltration, graft-versus-host disease, drug-induced, post-radiation, autoimmune, and otherwise unidentified...
April 16, 2024: Internal Medicine
#12
MULTICENTER STUDY
Yoko Edahiro, Tomonori Ochiai, Yoshinori Hashimoto, Michiko Ichii, Takeshi Okatani, Hiromi Omura, Kei Nakajima, Makoto Sasaki, Jun Ando, Tomoiku Takaku, Michiaki Koike, Koh Izumiyama, Junji Hiraga, Tomofumi Yano, Kensuke Usuki, Eiichi Ohtsuka, Kenji Yokoyama, Tatsuo Oyake, Naoki Takahashi, Tetsuya Nishida, Takafumi Nakao, Yasutaka Fukuda, Takashi Akasaka, Atsuko Mugitani, Miki Ando, Norio Komatsu
OBJECTIVES: Patients with myeloproliferative neoplasms (MPNs) are at higher risk of developing secondary malignancies. In this study, we focused on patients with MPNs that complicated lymphoid neoplasms. To analyze the real-world status of lymphoid neoplasm treatment in patients with pre-existing MPNs in Japan, we conducted a multicenter retrospective study. METHODS: Questionnaires were sent to collect the data on patients who were first diagnosed with either polycythemia vera, essential thrombocythemia or myelofibrosis and who later were complicated with lymphoid neoplasms defined as malignant lymphoma, multiple myeloma, or chronic lymphocytic leukemia/small cell lymphoma...
December 2024: Hematology (Amsterdam, Netherlands)
#13
JOURNAL ARTICLE
Zhengzheng Liao, Xianzhong Zeng, Xiaoling Guo, Qing Shi, Ziyun Tang, Ping Li, Cuiyun Chen, Mengxia Chen, Jianrong Chen, Jixiong Xu, Yaojun Cai
Hashimoto's thyroiditis (HT) is the most frequent autoimmune disorder. Growing work points to the involvement of aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor, in the regulation of immune homeostasis. However, the roles of AhR and its ligands in HT remains unclear. In this study, we leveraged public human database analyses to postulate that the AhR expression was predominantly in thyroid follicular cells, correlating significantly with the thyroid infiltration levels of multiple immune cells in HT patients...
April 13, 2024: European Journal of Pharmacology
#14
JOURNAL ARTICLE
Alessandro Parente, Mureo Kasahara, Vincent E De Meijer, Koji Hashimoto, Andrea Schlegel
Liver transplantation is the only lifesaving procedure for children with end-stage liver disease. The field is however heterogenic with various graft types, recipient age and weight and underlying diseases. Despite recently improved overall outcomes and the expanded use of living donors, waiting list mortality remains unacceptable particularly in small children and infants. Based on the known negative effect of elevated donor age, higher body mass index, and prolonged cold ischemia time, the number of available donors for pediatric recipients is limited...
April 16, 2024: Liver Transplantation
#15
JOURNAL ARTICLE
Yoshinori Hashimoto, Alessandro Lucchesi
The discovery of driver mutations in myeloproliferative neoplasms has significantly contributed to the management of patients with essential thrombocythaemia (ET). High-quality evidence has started to pave the way for targeted therapy. The review by Ferrer-Marín et al. further advances this discussion, highlighting how molecular profiling, including non-driver gene mutations, is set to revolutionize personalized treatment approaches for ET patients. Commentary on: Ferrer-Marín et al. Essential thrombocythemia: a contemporary approach with new drugs on the horizon...
April 15, 2024: British Journal of Haematology
#16
JOURNAL ARTICLE
Susumu Hijioka, Daiki Yamashige, Minoru Esaki, Goro Honda, Ryota Higuchi, Toshihiko Masui, Yasuhiro Shimizu, Masayuki Ohtsuka, Yusuke Kumamoto, Akio Katanuma, Naoto Gotohda, Hirofumi Akita, Michiaki Unno, Itaru Endo, Yukihiro Yokoyama, Suguru Yamada, Ippei Matsumoto, Takao Ohtsuka, Satoshi Hirano, Hiroaki Yasuda, Manabu Kawai, Taku Aoki, Masafumi Nakamura, Daisuke Hashimoto, Toshiki Rikiyama, Akihiko Horiguchi, Tsutomu Fujii, Shugo Mizuno, Keiji Hanada, Masaji Tani, Takashi Hatori, Tetsuhide Ito, Masataka Okuno, Shingo Kagawa, Hiroshi Tajima, Tatsuya Ishii, Motokazu Sugimoto, Shunsuke Onoe, Hideki Takami, Ryoji Takada, Takayuki Miura, Yusuke Kurita, Keiko Kamei, Yuko Mataki, Kazuichi Okazaki, Yoshifumi Takeyama, Hiroki Yamaue, Sohei Satoi
BACKGROUND & AIMS: Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases nonfunctioning small pNENs (NF-spNENs) in a large Japanese cohort to elucidate an optimal treatment strategy for NF-spNENs. METHODS: In this Japanese multicenter study, data were retrospectively collected from patients who underwent pancreatectomy between January 1996 and December 2019, were pathologically diagnosed with pNEN, and were treated according to the WHO 2019 classification...
April 12, 2024: Clinical Gastroenterology and Hepatology
#17
JOURNAL ARTICLE
Xiaodong Li, Lin-Hai Kurahara, Zhixin Zhao, Feiyan Zhao, Ryo Ishikawa, Kiyomi Ohmichi, Gaopeng Li, Tetsuo Yamashita, Takeshi Hashimoto, Mayumi Hirano, Zhihong Sun, Katsuya Hirano
BACKGROUND & AIMS: Inflammatory bowel disease is associated with carcinogenesis, which limits the prognosis of the patients. The local expression of proteinases and proteinase-activated receptor 1 (PAR1 ) increases in the inflammatory bowel disease. The present study investigated the therapeutic effects of PAR1 antagonism on colitis-associated carcinogenesis. METHODS: A colitis-associated carcinogenesis model was prepared in mice by treatment with azoxymethane (AOM) and dextran sulfate sodium (DSS)...
April 11, 2024: Cellular and Molecular Gastroenterology and Hepatology
#18
JOURNAL ARTICLE
Koichiro Nakajima, Masanosuke Oguri, Hiromitsu Iwata, Yukiko Hattori, Shingo Hashimoto, Kento Nomura, Kensuke Hayashi, Toshiyuki Toshito, Kenji Akita, Fumiya Baba, Hiroyuki Ogino, Akio Hiwatashi
BACKGROUND AND PURPOSE: This study evaluated long-term efficacy, safety, and changes in quality of life (QOL) of patients after image-guided proton therapy (IGPT) for operable stage I non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This single-institutional prospective phase 2 study enrolled patients with operable histologically confirmed stage IA or IB NSCLC (7th edition of UICC). The prescribed dose was 66 Gy relative biological effectiveness equivalents (GyRBE) in 10 fractions for peripheral lesions, or 72...
April 11, 2024: Radiotherapy and Oncology
#19
JOURNAL ARTICLE
Hanna Borysewicz-Sańczyk, Natalia Wawrusiewicz-Kurylonek, Joanna Gościk, Beata Sawicka, Filip Bossowski, Domenico Corica, Tommaso Aversa, Małgorzata Waśniewska, Artur Bossowski
Hashimoto's thyroiditis (HT) and Graves' disease (GD) are common autoimmune endocrine disorders in children. Studies indicate that apart from environmental factors, genetic background significantly contributes to the development of these diseases. This study aimed to assess the prevalence of selected single-nucleotide polymorphisms (SNPs) of Il7R, CD226, CAPSL, and CLEC16A genes in children with autoimmune thyroid diseases. We analyzed SNPs at the locus rs3194051, rs6897932 of IL7R, rs763361 of CD226, rs1010601 of CAPSL, and rs725613 of CLEC16A gene in 56 HT patients, 124 GD patients, and 156 healthy children...
April 4, 2024: International Journal of Molecular Sciences
#20
REVIEW
Agnieszka Galanty, Marta Grudzińska, Wojciech Paździora, Piotr Służały, Paweł Paśko
Brassica vegetables are widely consumed all over the world, especially in North America, Asia, and Europe. They are a rich source of sulfur compounds, such as glucosinolates (GLSs) and isothiocyanates (ITCs), which provide health benefits but are also suspected of having a goitrogenic effect. Adhering to PRISMA guidelines, we conducted a systematic review to assess the impact of dietary interventions on thyroid function, in terms of the potential risk for people with thyroid dysfunctions. We analyzed the results of 123 articles of in vitro, animal, and human studies, describing the impact of brassica plants and extracts on thyroid mass and histology, blood levels of TSH, T3, T4, iodine uptake, and the effect on thyroid cancer cells...
April 3, 2024: International Journal of Molecular Sciences
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
