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Hashimotos disease

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https://www.readbyqxmd.com/read/28728146/chronic-kidney-disease-predicts-survival-in-patients-with-idiopathic-pulmonary-fibrosis
#1
Kohei Ikezoe, Tomohiro Handa, Kiminobu Tanizawa, Hideki Yokoi, Takeshi Kubo, Kensaku Aihara, Akihiko Sokai, Yoshinari Nakatsuka, Seishu Hashimoto, Kiyoshi Uemasu, Susumu Sato, Shigeo Muro, Sonoko Nagai, Motoko Yanagita, Kazuo Chin, Toyohiro Hirai, Yoshio Taguchi, Michiaki Mishima
BACKGROUND: The prevalence of chronic kidney disease (CKD) increases with age as with idiopathic pulmonary fibrosis (IPF). OBJECTIVES: We assessed the prevalence of CKD (stages 3-5) and investigated the relationship of CKD to clinical features and outcomes in patients with IPF. METHODS: This study comprised 123 patients with IPF; 61 subjects with chronic obstructive pulmonary disease (COPD), which was reportedly associated with CKD, were also enrolled as a disease control...
July 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28725903/suppressive-effects-of-dietary-epa-rich-fish-oil-on-the-degradation-of-elastin-fibers-in-the-aortic-wall-in-nicotine-administered-mice
#2
Hirona Kugo, Nobuhiro Zaima, Megumi Onozato, Chie Miyamoto, Keisuke Hashimoto, Kenichi Yanagimoto, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease involving gradual dilation of the abdominal aorta. Recent studies suggest that nicotine, which is a primary component in cigarette smoke, is closely associated with the development and rupture of an AAA. Nicotine accelerates AAA development through the weakening of the vascular wall by increasing oxidative stress and matrix metalloproteinase (MMP)-2 expression. However, little is known about preventing the AAA induced by nicotine. A non-surgical means of preventing the weakening of the vascular wall before the onset of AAA by functional food factors would be a valuable option over surgery...
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28724913/time-averaged-disease-activity-fits-better-joint-destruction-in-rheumatoid-arthritis
#3
Hideaki Tsuji, Koichiro Yano, Moritoshi Furu, Noriyuki Yamakawa, Katsunori Ikari, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Wataru Yamamoto, Koichiro Ohmura, Atsuo Taniguchi, Shigeki Momohara, Fumihiko Matsuda, Cornelia F Allaart, Hisashi Yamanaka, Tsuneyo Mimori, Chikashi Terao
Disease activity of rheumatoid arthritis (RA), evaluated as Disease Activity Score (DAS), is associated with joint destruction. Since joint destruction reflects the history of disease activities, we hypothesized that time-averaged disease activity would better correlate with joint destruction than one-time disease activity. We recruited RA patients in IORRA (n = 557) and KURAMA (n = 204) cohorts, and calculated time-averaged DAS28 to model a modified Sharp/van der Heijde score (SHS). We evaluated the fitting of the model using time-averaged DAS28 among 1000 models in which we randomly picked up one-time DAS28...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724639/production-of-reactive-persulfide-species-in-chronic-obstructive-pulmonary-disease
#4
Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose
BACKGROUND: Oxidative stress is a major aetiological factor driving chronic obstructive pulmonary disease (COPD). Recently recognised as potent antioxidants, reactive persulfide and polysulfide species are biosynthesised by cystathionine β-synthase and cystathionine γ-lyase. The production of reactive persulfide and polysulfide species in the lungs of patients with COPD remain unknown. OBJECTIVES: The aim of this study was to examine the production of reactive persulfides and polysulfides, such as glutathione persulfide (GSSH), cysteine persulfide (CysSSH) and glutathione trisulfide (GSSSH), in lung-resident cells and epithelial lining fluid (ELF) obtained from patients with mild to moderate COPD...
July 19, 2017: Thorax
https://www.readbyqxmd.com/read/28724056/prevalence-of-pancreatic-autoantibodies-in-non-diabetic-patients-with-autoimmune-thyroid-disease-and-its-relation-to-insulin-secretion-and-glucose-tolerance
#5
Carolina Sallorenzo, Regina Silva, Teresa Kasamatsu, Sérgio Dib
Objective: We evaluated the prevalence of glutamic acid decarboxylase (GADA) and tyrosine phosphatase-protein antibodies (IA2A), their titers and their relation to first phase insulin response (FPIR) and glucose tolerance in autoimmune thyroid diseases (ATDs) patients. Subjects and methods: Graves' disease (GD; n = 181) and Hashimoto's thyroiditis (HT; n = 143) patients in addition to healthy controls (n = 93) were studied. Secondly, FPIR and oral glucose tolerance tests (OGTT) were performed in 11 anti-pancreatic islet-cell (+) and in 20 anti-pancreatic-cell (-) patients...
July 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28721130/premature-ovarian-failure
#6
REVIEW
Katarzyna Jankowska
Premature ovarian failure (POF) is the term usually used to describe women aged younger than 40 years, who present with amenorrhoea, hypergonadotropic hypogonadism, and infertility. POF is a devastating diagnosis for reproductive-aged women. The clinical presentation is diverse, and several different disorders can lead to premature ovarian failure. POF has serious health consequences, including psychological distress, infertility, osteoporosis, autoimmune disorders, ischaemic heart disease, and increased risk of mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28711902/risk-stratified-surveillance-and-cost-effectiveness-of-follow-up-after-radical-cystectomy-in-patients-with-muscle-invasive-bladder-cancer
#7
Ayumu Kusaka, Shingo Hatakeyama, Shogo Hosogoe, Itsuto Hamano, Hiromichi Iwamura, Naoki Fujita, Ken Fukushi, Takuma Narita, Kazuhisa Hagiwara, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Chikara Ohyama
BACKGROUND: The recurrence risk stratification and the cost effectiveness of oncological surveillance after radical cystectomy are not clear. We aimed to develop a risk stratification and a surveillance protocol with improved cost effectiveness after radical cystectomy. RESULTS: Of 581 enrolled patients, 175 experienced disease recurrences. The pathology-based protocol presented significant differences in recurrence-free survival between normal- and high-risk patients, but the medical expense was high, especially in normal-risk (≤pT2pN0) patients...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711489/time-course-microarrays-reveal-early-activation-of-the-immune-transcriptome-in-a-choline-deficient-mouse-model-of-liver-injury
#8
Koji Mitsumoto, Rina Watanabe, Katsuki Nakao, Hisaki Yonenaka, Takao Hashimoto, Norihisa Kato, Thanutchaporn Kumrungsee, Noriyuki Yanaka
AIMS: Choline-deficient diet is extensively used as a model of nonalcoholic fatty liver disease (NAFLD). In this study, we explored genes in the liver for which the expression changed in response to the choline-deficient (CD) diet. MAIN METHODS: Male CD-1 mice were divided into two groups and fed a CD diet with or without 0.2% choline bitartrate for one or three weeks. Hepatic levels of choline metabolites were analyzed by using liquid chromatography mass spectrometry and hepatic gene expression profiles were examined by DNA microarray analysis...
July 12, 2017: Life Sciences
https://www.readbyqxmd.com/read/28711405/a-unique-glycan-isoform-of-transferrin-in-cerebrospinal-fluid-a-potential-diagnostic-marker-for-neurological-diseases
#9
REVIEW
Kyoka Hoshi, Hiromi Ito, Yuka Matsumoto, Kiyoshi Saito, Takashi Honda, Yoshiki Yamaguchi, Yasuhiro Hashimoto
BACKGROUND: cerebrospinal fluid (CSF) is sequestered from blood by the blood-brain barrier and directly communicates with brain parenchymal interstitial fluid, leading to contain specific biomarkers of neurological diseases. SCOPE OF REVIEW: CSF contains glycan isoforms of transferrin (Tf): one appears to be derived from the brain and the other from blood. MAJOR CONCLUSIONS: CSF contains two glycan-isoforms; brain-type Tf and serum-type Tf...
July 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28706507/epigenetics-and-autoimmune-thyroid-diseases
#10
REVIEW
Fabio Coppedè
Increasing evidence suggests that epigenetic modifications, including changes in DNA methylation, covalent modifications of histone tails, and gene silencing mediated by non-coding RNA molecules, play a substantial role in the pathogenesis of autoimmune disorders and might be seen as the result of environmental insults that trigger these conditions. Studies in cells and tissues of patients with autoimmune thyroid diseases (AITD), and particularly in Graves' disease (GD) and Hashimoto's thyroiditis (HT), are increasingly revealing altered epigenetic marks and resultant deregulation of gene expression levels, but the available data are still limited to be translated into the clinical settings...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28705644/discovery-of-ds79182026-a-potent-orally-active-hepcidin-production-inhibitor
#11
Takeshi Fukuda, Riki Goto, Toshihiro Kiho, Kenjiro Ueda, Sumie Muramatsu, Masami Hashimoto, Anri Aki, Kengo Watanabe, Naoki Tanaka
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (DS79182026), which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model...
July 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28702206/gender-difference-in-the-impact-of-gynoid-and-android-fat-masses-on-the-progression-of-hepatic-steatosis-in-japanese-patients-with-type-2-diabetes
#12
Ryotaro Bouchi, Tatsuya Fukuda, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
BACKGROUND: Increased visceral adiposity is strongly associated with non-alcoholic fatty liver disease (NAFLD). However, little attention has been paid to the association between the change in subcutaneous adipose mass and the progression of non-alcoholic fatty liver disease (NAFLD). We aimed to investigate whether increased subcutaneous adipose tissue (gynoid fat mass) could be protective against the progression of NAFLD in Japanese patients with type 2 diabetes. METHODS: This is a retrospective observational study of 294 Japanese patients with type 2 diabetes (65 ± 10 years old, 40% female)...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28699391/anti-pd-1-antibody-therapy-induces-hashimoto-s-disease-with-increase-in-peripheral-blood-follicular-helper-t-cells
#13
Keiichi Torimoto, Yosuke Okada, Shingo Nakayamada, Satoshi Kubo, Yoshiya Tanaka
Not Applicable.
July 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28697689/vitamin-d-treatment-in-patients-with-hashimoto-s-thyroiditis-may-decrease-the-development-of-hypothyroidism
#14
Bekir Ucan, Mustafa Sahin, Muyesser Sayki Arslan, Nujen Colak Bozkurt, Muhammed Kizilgul, Askin Güngünes, Erman Cakal, Mustafa Ozbek
The relationship between Hashimoto's thyroiditis and vitamin D has been demonstrated in several studies. The aim of the present study was to evaluate vitamin D concentrations in patients with Hashimoto's thyroiditis, the effect of vitamin D therapy on the course of disease, and to determine changes in thyroid autoantibody status and cardiovascular risk after vitamin D therapy. We included 75 patients with Hashimoto's thyroiditis and 43 healthy individuals. Vitamin D deficiency is defined as a 25-hydroxy vitamin D (25(OH)D3) concentration less than 20ng/mL...
July 12, 2017: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/28696209/hashimoto-s-thyroiditis-predicts-outcome-in-intrathyroidal-papillary-thyroid-cancer
#15
Vincenzo Marotta, Concetta Sciammarella, Maria Grazia Chiofalo, Claudio Gambardella, Claudio Bellevicine, Marica Grasso, Giovanni Conzo, Giovanni Docimo, Gerardo Botti, Nunzia Simona Losito, Giancarlo Troncone, Maurizio De Palma, Laura Giacomelli, Luciano Pezzullo, Annamaria Al Colao, Antongiulio Faggiano
Hashimoto's thyroiditis (HT) seems to have favourable prognostic impact on papillary thyroid cancer (PTC), but data were obtained analyzing all disease stages. Given that HT-related microenvironment involves solely the thyroid, we aimed to assess relationship between HT, as detected through pathological assessment, and outcome in intrathyroidal PTC. This was a multicenter, retrospective, observational study including 301 PTC with no evidence of extrathyroidal disease. Primary study endpoint was the rate of clinical remission...
July 10, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28692197/the-asia-pacific-working-party-on-nonalcoholic-fatty-liver-disease-guidelines-2017-part-2-management-and-special-groups
#16
Shiv Chitturi, Vincent Wai-Sun Wong, Wah-Kheong Chan, Grace Lai-Hung Wong, Simon Kin-Hung Wong, Jose Sollano, Yen-Hsuan Ni, Chun-Jen Liu, Yu-Cheng Lin, Laurentius Adrianto Lesmana, Seung Up Kim, Etsuko Hashimoto, Masahide Hamaguchi, Khean-Lee Goh, Jiangao Fan, Ajay Duseja, Yock Young Dan, Yogesh Chawla, Geoff Farrell, Henry Lik-Yuen Chan
No abstract text is available yet for this article.
July 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28690889/imbalances-in-t-cell-related-transcription-factors-among-patients-with-hashimoto-s-thyroiditis
#17
Vahid Safdari, Ebrahim Alijani, Maryam Nemati, Abdollah Jafarzadeh
OBJECTIVES: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto's thyroiditis (HT). Differentiation of effector T helper (Th) 1, Th2, Th17 and regulatory T cell (Treg) lymphocytes is regulated by transcription factors, including Th1-specific T box (T-bet), GATA binding protein-3 (GATA3), retinoid-related orphan receptor (ROR)-α and forkhead box P3 (FOXP3). This study aimed to investigate Th1/Th2, Th1/Treg, Th2/Treg and Th17/Treg balances at the level of these transcription factors...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28689103/-123-i-meta-iodobenzylguanidine-mibg-myocardial-scintigraphy-in-patients-showing-scans-without-evidence-of-dopaminergic-deficits-swedds
#18
Fumihito Yoshii, Yusuke Moriya, Tomohide Ohnuki, Masafuchi Ryo, Wakoh Takahashi, Saori Kohara, Jun Hashimoto
OBJECTIVE: Scans without evidence of dopaminergic deficits (SWEDDs) in dopamine transporter single-photon emission computed tomography (DAT-SPECT) are found in 3.6-19.6% of patients with clinically suspected Parkinson's disease (PD). We investigated whether combined use of (123)I-meta-iodobenzylguanidine (MIBG) myocardial scintigraphy would be helpful to differentiate PD among SWEDDs patients. PATIENTS AND METHODS: 145 patients with clinically suspected PD underwent both DAT-SPECT and MIBG myocardial scintigraphy...
June 27, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28686352/the-ratio-of-visceral-to-subcutaneous-fat-area-predicts-cardiovascular-events-in-patients-with-type-2-diabetes
#19
Tatsuya Fukuda, Ryotaro Bouchi, Takato Takeuchi, Yujiro Nakano, Masanori Murakami, Isao Minami, Hajime Izumiyama, Koshi Hashimoto, Takanobu Yoshimoto, Yoshihiro Ogawa
AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) (V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes. MATERIALS AND METHODS: 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% female) were enrolled. VFA (cm(2) ) and SFA (cm(2) ) were assessed by dual bioelectrical impedance analyzer (BIA). The patients were divided into four groups according to the quartiles of V/S ratio...
July 7, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28681682/biomarker-for-nontuberculous-mycobacterial-pulmonary-disease-in-patients-with-rheumatoid-arthritis-anti-glycopeptidolipid-core-antigen-immunoglobulin-a-antibodies
#20
Kanako Iwata, Shomi Oka, Hirotaka Tsuno, Hiroshi Furukawa, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Naoyuki Tsuchiya, Masao Katayama, Shigeto Tohma
OBJECTIVE: Nontuberculous mycobacterial (NTM) pulmonary disease is occasionally associated with rheumatoid arthritis (RA), influencing the therapeutic strategy of RA. Since chronic lung diseases are frequently associated with RA, the diagnosis of NTM pulmonary disease is quite difficult in RA patients. Recently, a serological diagnostic test detecting serum immunoglobulin A against the glycopeptidolipid (GPL) core antigen was developed. We investigated the serum levels of anti-GPL antibodies in RA patients to determine the usefulness for detecting NTM pulmonary disease...
July 6, 2017: Modern Rheumatology
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