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Hashimotos disease

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https://www.readbyqxmd.com/read/28073605/comprehensive-association-analysis-of-27-genes-from-the-gabaergic-system-in-japanese-individuals-affected-with-schizophrenia
#1
Shabeesh Balan, Kazuo Yamada, Yoshimi Iwayama, Takanori Hashimoto, Tomoko Toyota, Chie Shimamoto, Motoko Maekawa, Shu Takagai, Tomoyasu Wakuda, Yosuke Kameno, Daisuke Kurita, Kohei Yamada, Mitsuru Kikuchi, Tasuku Hashimoto, Nobuhisa Kanahara, Takeo Yoshikawa
Involvement of the gamma-aminobutyric acid (GABA)-ergic system in schizophrenia pathogenesis through disrupted neurodevelopment has been highlighted in numerous studies. However, the function of common genetic variants of this system in determining schizophrenia risk is unknown. We therefore tested the association of 375 tagged SNPs in genes derived from the GABAergic system, such as GABAA receptor subunit genes, and GABA related genes (glutamate decarboxylase genes, GABAergic-marker gene, genes involved in GABA receptor trafficking and scaffolding) in Japanese schizophrenia case-control samples (n=2926; 1415 cases and 1511 controls)...
January 7, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28073128/the-effect-of-vitamin-d-on-thyroid-autoimmunity-in-levothyroxine-treated-women-with-hashimoto-s-thyroiditis-and-normal-vitamin-d-status
#2
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background: Low vitamin D status is associated with autoimmune thyroid disease. Oral vitamin D supplementation was found to reduce titers of thyroid antibodies in levothyroxine-treated women with postpartum thyroiditis and low vitamin D status. Methods: The study included 34 women with Hashimoto's thyroiditis and normal vitamin D status (serum 25-hydroxyvitamin D levels above 30 ng/mL) who had been treated for at least 6 months with levothyroxine. On the basis of patient preference, women were divided into 2 groups, receiving (n=18) or not receiving (n=16) oral vitamin D preparations (2000 IU daily)...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28070798/does-vitamin-d-play-a-role-in-autoimmune-endocrine-disorders-a-proof-of-concept
#3
REVIEW
Barbara Altieri, Giovanna Muscogiuri, Luigi Barrea, Chantal Mathieu, Carla V Vallone, Luca Mascitelli, Giorgia Bizzaro, Vincenzo M Altieri, Giacomo Tirabassi, Giancarlo Balercia, Silvia Savastano, Nicola Bizzaro, Cristina L Ronchi, Annamaria Colao, Alfredo Pontecorvi, Silvia Della Casa
In the last few years, more attention has been given to the "non-calcemic" effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases. In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1α-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties...
January 9, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28070163/development-of-reverse-transcription-loop-mediated-isothermal-amplification-for-simple-and-rapid-detection-of-promyelocytic-leukemia-retinoic-acid-receptor-%C3%AE-mrna
#4
Yuki Hashimoto, Yuki Hatayama, Nao Kojima, Shota Morishita, Satoko Matsumoto, Yuzuru Hosoda, Ayako Hara, Toru Motokura
BACKGROUND: Acute promyelocytic leukemia (APL) is a disease characterized by expression of Promyelocytic Leukemia-Retinoic Acid Receptor α (PML-RARα) chimeric mRNA. Although APL is curable, early death due to hemorrhage is a major problem. Here, we report the development of a simple and rapid diagnostic method for APL based on reverse transcription loop-mediated isothermal amplification (RT-LAMP). METHODS: An RT-LAMP primer set was designed to detect three types of PML-RARα mRNA in a single reaction...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28066606/lobectomy-and-limited-resection-in-small-sized-peripheral-non-small-cell-lung-cancer
#5
Terumoto Koike, Teruaki Koike, Seijiro Sato, Takehisa Hashimoto, Tadashi Aoki, Katsuo Yoshiya, Yasushi Yamato, Takehiro Watanabe, Kohei Akazawa, Shin-Ichi Toyabe, Masanori Tsuchida
BACKGROUND: Although lobectomy is the standard surgical procedure for non-small cell lung cancer (NSCLC), recent studies show favorable outcomes after limited resection in patients with small-sized peripheral tumors. We conducted a randomized controlled trial of such patients to estimate postoperative outcomes and pulmonary function following these surgical techniques. METHODS: Between 2005 and 2008, eligible patients with tumors of 2 cm or less were randomly assigned 1:1 to undergo lobectomy or limited resection; 32 and 33 NSCLC patients in each group, respectively, were analyzed...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28062665/genome-wide-association-studies-identify-prkcb-as-a-novel-genetic-susceptibility-locus-for-primary-biliary-cholangitis-in-the-japanese-population
#6
Minae Kawashima, Yuki Hitomi, Yoshihiro Aiba, Nao Nishida, Kaname Kojima, Yosuke Kawai, Hitomi Nakamura, Atsushi Tanaka, Mikio Zeniya, Etsuko Hashimoto, Hiromasa Ohira, Kazuhide Yamamoto, Masanori Abe, Kazuhiko Nakao, Satoshi Yamagiwa, Shuichi Kaneko, Masao Honda, Takeji Umemura, Takafumi Ichida, Masataka Seike, Shotaro Sakisaka, Masaru Harada, Osamu Yokosuka, Yoshiyuki Ueno, Michio Senju, Tatsuo Kanda, Hidetaka Shibata, Takashi Himoto, Kazumoto Murata, Yasuhiro Miyake, Hirotoshi Ebinuma, Makiko Taniai, Satoru Joshita, Toshiki Nikami, Hajime Ota, Hiroshi Kouno, Hirotaka Kouno, Makoto Nakamuta, Nobuyoshi Fukushima, Motoyuki Kohjima, Tatsuji Komatsu, Toshiki Komeda, Yukio Ohara, Toyokichi Muro, Tsutomu Yamashita, Kaname Yoshizawa, Yoko Nakamura, Masaaki Shimada, Noboru Hirashima, Kazuhiro Sugi, Keisuke Ario, Eiichi Takesaki, Atsushi Naganuma, Hiroshi Mano, Haruhiro Yamashita, Kouki Matsushita, Kazuhiko Yamauchi, Fujio Makita, Hideo Nishimura, Kiyoshi Furuta, Naohiro Takahashi, Masahiro Kikuchi, Naohiko Masaki, Tomohiro Tanaka, Sumito Tamura, Akira Mori, Shintaro Yagi, Ken Shirabe, Atsumasa Komori, Kiyoshi Migita, Masahiro Ito, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Michio Yasunami, Shinji Shimoda, Kenichi Harada, Hiroto Egawa, Yoshihiko Maehara, Shinji Uemoto, Norihiro Kokudo, Hajime Takikawa, Hiromi Ishibashi, Kazuaki Chayama, Masashi Mizokami, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) and POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we performed GWAS in an additional 1,923 Japanese individuals (894 PBC cases and 1,029 healthy controls), and combined the results with the previous data. This GWAS, together with a subsequent replication study in an independent set of 7,024 Japanese individuals (512 PBC cases and 6,512 healthy controls), identified PRKCB (rs7404928) as a novel susceptibility locus for PBC (odds ratio [OR] = 1...
January 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28061551/consanguinity-and-the-risk-of-hashimoto-s-thyroiditis
#7
Raja Zaghlol, Alireza Haghighi, Motasem Alkhayyat, Othman Farhan, Amal Owaydah, Mu'taz Massad, Mohammad Atari, Ayman Aref Zayed
BACKGROUND: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease that may lead to hypothyroidism due to progressive destruction of thyroid. The etiology of HT is unclear. However, it is associated with multiple genetic predispositions. Consanguinity has been associated with an increased susceptibility to different inherited conditions. This study, for the first time, investigated the association between consanguinity and risk of HT. METHODS: Using a case-control study design, we compared 298 HT patients with two subject groups; a) 299 participants with non-HT hypothyroidism, and b) 298 healthy control participants...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28055088/myxedema-psychosis-in-a-patient-with-undiagnosed-hashimoto-thyroiditis
#8
Matthew M Mavroson, Nirav Patel, Eleonora Akker
Myxedema psychosis is uncommon in patients with primary hypothyroidism. Most often, this disease state can be found in patients with Hashimoto thyroiditis or after total thyroidectomy. Chronic hypothyroidism can lead to an insidious onset of psychiatric symptoms in patients, such as dementia, delirium, psychosis, hallucinations, and coma. A 31-year-old man with an unremarkable medical history was brought to the psychiatric emergency department for new-onset aggression, paranoid behavior, and hallucinations for 4 days...
January 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28053144/excess-app-o-glycosylation-by-galnac-t6-decreases-a%C3%AE-production
#9
Keiko Akasaka-Manya, Masaki Kawamura, Hiroki Tsumoto, Yuko Saito, Yuriko Tachida, Shinobu Kitazume, Hiroyuki Hatsuta, Yuri Miura, Shin-Ichi Hisanaga, Shigeo Murayama, Yasuhiro Hashimoto, Hiroshi Manya, Tamao Endo
Alterations of the structure and/or amount of glycans present on proteins are associated with many diseases. We previously demonstrated that changes in N-glycans alter Aβ production. In the present study, we focused on the relationship between Alzheimer's disease (AD) and O-glycan, another type of glycan. The UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family functions in the first step of mucin-type O-glycan synthesis. Analysis of the expression of GalNAc-Ts in the human brain using real-time PCR revealed that the expression of several GalNAc-Ts was altered with sporadic AD progression...
January 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28052155/effect-of-background-liver-cirrhosis-on-outcomes-of-hepatectomy-for-hepatocellular-carcinoma
#10
Kazunari Sasaki, Junichi Shindoh, Georgios A Margonis, Yujiro Nishioka, Nikolaos Andreatos, Akinari Sekine, Masaji Hashimoto, Timothy M Pawlik
Importance: Background hepatocarcinogenesis is considered a major cause of postoperative recurrence of de novo hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). The degree of underlying liver injury has reportedly correlated with surgical outcomes of HCC. However, the pattern and annual rate of recurrence of postoperative de novo HCC are still unclear. Objective: To clarify the pattern and rate of recurrence of de novo HCC in patients with LC...
January 4, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28040434/corrigendum-to-chronic-restraint-stress-triggers-dopaminergic-and-noradrenergic-neurodegeneration-possible-role-of-chronic-stress-in-the-onset-of-parkinson-s-disease-brain-behav-immun-51-2016-39-46
#11
Shuei Sugama, Kazunari Sekiyama, Tohru Kodama, Yoshiki Takamatsu, Takato Takenouchi, Makoto Hashimoto, Bruno Conti, Yoshihiko Kakinuma
No abstract text is available yet for this article.
December 28, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28035928/consecutive-analysis-of-bace1-function-on-developing-and-developed-neuronal-cells
#12
Yuji Kamikubo, Nobumasa Takasugi, Kazue Niisato, Yoshie Hashimoto, Takashi Sakurai
The amyloid-β protein precursor (AβPP) is cleaved by a transmembrane protease termed β-site AβPP cleavage enzyme (BACE1), which is being explored as a target for therapy and prevention of Alzheimer's disease (AD). Although genetic deletion of BACE1 results in abolished amyloid pathology in AD model mice, it also results in neurodevelopmental phenotypes such as hypomyelination and synaptic loss, observed in schizophrenia and autism-like phenotype. These lines of evidence indicate that the inhibition of BACE1 causes adverse side effects during the neurodevelopmental stage...
December 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28029020/clinical-update-in-aspects-of-the-management-of-autoimmune-thyroid-diseases
#13
REVIEW
Duncan J Topliss
Aspects of autoimmune thyroid disease updated in this review include: immunoglobulin G4 (IgG4)-related thyroid disease (Riedel's thyroiditis, fibrosing variant of Hashimoto's thyroiditis, IgG4-related Hashimoto's thyroiditis, and Graves' disease with elevated IgG4 levels); recent epidemiological studies from China and Denmark indicating that excess iodine increases the incidence of Hashimoto's thyroiditis and hypothyroidism; immunomodulatory agents (ipilimumab, pembrolizumab, nivolumab) activate immune response by inhibiting T-cell surface receptors which down-regulate immune response, i...
December 2016: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28024116/mulberry-cells-in-the-thyroid-warthin-finkeldey-like-cells-in-hashimoto-thyroiditis-associated-lymphoma
#14
Razvan Lapadat, Moon Woo Nam, Swati Mehrotra, Milind Velankar, Stefan E Pambuccian
Warthin-Finkeldey type giant cells were first described in autopsies performed on young children who died during the highly lethal measles epidemic in Palermo during the winter of 1908. The cells had 8-15 nuclei without identifiable cytoplasm within the germinal centers of lymphoid organs resembling megakaryocytes. We describe a case of Hashimoto thyroiditis with an enlarging substernal throid mass. The resection specimen contained many Warthin-Finkeldey-Like Cells (WFLC) in an extranodal marginal zone lymphoma (MALT type) with focal transformation to diffuse large B-cell lymphoma...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28018345/increased-toll-like-receptors-activity-and-tlr-ligands-in-patients-with-autoimmune-thyroid-diseases
#15
Shiqiao Peng, Chenyan Li, Xinyi Wang, Xin Liu, Cheng Han, Ting Jin, Shanshan Liu, Xiaowen Zhang, Hanyi Zhang, Xue He, Xiaochen Xie, Xiaohui Yu, Chuyuan Wang, Ling Shan, Chenling Fan, Zhongyan Shan, Weiping Teng
OBJECTIVE: Autoimmune thyroid disease (AITD) is an organ-specific disorder due to the interplay between environmental and genetic factors. Toll-like receptors (TLRs) are pattern recognition receptors expressed abundantly on monocytes. There is a paucity of data on TLR expression in AITD. The aim of this study was to examine TLR expression, activation, ligands, and downstream signaling adaptors in peripheral blood mononuclear cells (PBMCs) extracted from untreated AITD patients and healthy controls...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/28013570/polymorphisms-and-expression-of-toll-like-receptors-in-autoimmune-thyroid-diseases
#16
Naoya Inoue, Yuka Katsumata, Mikio Watanabe, Naoko Ishido, Yu Manabe, Ayano Watanabe, Ryota Masutani, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs). Prognosis of AITDs varies in each patient. Toll-like receptors (TLRs) are pattern-recognition receptors that activate signaling pathways involved in the production of proinflammatory cytokines. UNC93B1 is a transcription factor of TLR7 and TLR9. In this study, we examined the association of TLR expression and TLR and UNC93B1 polymorphisms with the development and prognosis of AITDs. The ratio of intracellular TLR7 (iTLR7) and iTLR9 intensities in B cells was lower in patients with GD in remission than in patients with intractable GD (p = 0...
December 26, 2016: Autoimmunity
https://www.readbyqxmd.com/read/28012120/improvement-in-automated-quantitation-of-myocardial-perfusion-abnormality-by-using-iterative-reconstruction-image-in-combination-with-resolution-recovery-attenuation-and-scatter-corrections-for-the-detection-of-coronary-artery-disease
#17
Taiki Chono, Masahisa Onoguchi, Takayuki Shibutani, Akiyoshi Hashimoto, Tomoaki Nakata, Naoya Yama, Kazufumi Tsuchihashi, Masamitsu Hatakenaka
OBJECTIVE: An iterative reconstruction method in combination with resolution recovery, attenuation and scatter corrections (IR-RASC) can improve image quality. It, however, is undetermined whether this technique can improve the detection of coronary artery disease (CAD) when automated quantitative analysis is used. This study evaluated diagnostic values of IR-RASC in combination with automated quantitative analysis in stress myocardial perfusion imaging (MPI) in the CAD detection. METHODS: This study enrolled consecutive 64 patients (mean age 66...
December 24, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28000249/amicrobial-pustulosis-of-the-folds-report-of-4-cases
#18
Michael Z Wang, Michael J Camilleri, Ruifeng Guo, Carilyn N Wieland
Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Common histopathologic features of skin biopsies in these patients were intracorneal, subcorneal, intraepidermal, perivascular, perifollicular, and interstitial neutrophilic inflammation...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27998764/mitochondrial-proteins-nip-snap-1-and-2-are-a-target-for-the-immunomodulatory-activity-of-clarithromycin-which-involves-nf-%C3%AE%C2%BAb-mediated-cytokine-production
#19
Soh Yamamoto, Noriko Ogasawara, Keisuke Yamamoto, Chika Uemura, Yoshiaki Takaya, Tsukasa Shiraishi, Toyotaka Sato, Shin Hashimoto, Hiroyuki Tsutsumi, Kenichi Takano, Tetsuo Himi, Shin-Ichi Yokota
Macrolide antibiotics have immunomodulatory activities, including suppression of cytokine production, cell adhesion molecule expression, and mucin production. These immunomodulatory activities improve the symptoms of respiratory diseases associated with chronic inflammation. However, the underlying molecular mechanism(s) is not well understood yet. To address this, we prepared clarithromycin (CAM)-conjugated Sepharose and examined bound cellular proteins by proteome analysis. We identified mitochondrial proteins 4-nitrophenylphosphatase domain and non-neuronal synaptosomal associated protein 25-like protein homolog (NIP-SNAP)-1 and -2 and very long-chain acyl-CoA dehydrogenase (VLCAD) as CAM-binding proteins...
December 18, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27995687/pathological-findings-of-nonalcoholic-steatohepatitis-and-nonalcoholic-fatty-liver-disease
#20
EDITORIAL
Michiie Sakamoto, Hanako Tsujikawa, Kathryn Effendi, Hidenori Ojima, Kenichi Harada, Yoh Zen, Fukuo Kondo, Masayuki Nakano, Masayoshi Kage, Yoshio Sumida, Etsuko Hashimoto, Gotaro Yamada, Takeshi Okanoue, Kazuhiko Koike
No abstract text is available yet for this article.
January 2017: Pathology International
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