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https://www.readbyqxmd.com/read/29863842/constructing-highly-uniform-onion-ring-like-graphitic-carbon-nitride-for-efficient-visible-light-driven-photocatalytic-hydrogen-evolution
#1
Lifeng Cui, Jialing Song, Allister F McGuire, Shifei Kang, Xueyou Fang, Junjie Wang, Chaochuang Yin, Xi Li, Yangang Wang, Bianxiao Cui
The introduction of microstructure to the metal-free graphitic carbon nitride (g-C3N4) photocatalyst holds promise in enhancing its catalytic performance. However, producing such microstructured g-C3N4 remains technically challenging due to a complicated synthetic process and high cost. In this study, we develop a facile and in-air chemical vapor deposition (CVD) method that produces onion-ring-like g-C3N4 microstructures in a simple, reliable, and economical manner. This method involves the use of randomly packed 350 nm SiO2 microspheres as a hard template and melamine as a CVD precursor for the deposition of a thin layer of g-C3N4 in the narrow space between the SiO2 microspheres...
June 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29648779/the-role-of-membrane-curvature-in-nanoscale-topography-induced-intracellular-signaling
#2
Hsin-Ya Lou, Wenting Zhao, Yongpeng Zeng, Bianxiao Cui
Over the past decade, there has been growing interest in developing biosensors and devices with nanoscale and vertical topography. Vertical nanostructures induce spontaneous cell engulfment, which enhances the cell-probe coupling efficiency and the sensitivity of biosensors. Although local membranes in contact with the nanostructures are found to be fully fluidic for lipid and membrane protein diffusions, cells appear to actively sense and respond to the surface topography presented by vertical nanostructures...
May 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29570360/interfacing-cells-with-vertical-nanoscale-devices-applications-and-characterization
#3
Allister F McGuire, Francesca Santoro, Bianxiao Cui
Measurements of the intracellular state of mammalian cells often require probes or molecules to breach the tightly regulated cell membrane. Mammalian cells have been shown to grow well on vertical nanoscale structures in vitro, going out of their way to reach and tightly wrap the structures. A great deal of research has taken advantage of this interaction to bring probes close to the interface or deliver molecules with increased efficiency or ease. In turn, techniques have been developed to characterize this interface...
March 23, 2018: Annual Review of Analytical Chemistry
https://www.readbyqxmd.com/read/29536037/rotation-of-endosomes-demonstrates-coordination-of-molecular-motors-during-axonal-transport
#4
Luke Kaplan, Athena Ierokomos, Praveen Chowdary, Zev Bryant, Bianxiao Cui
Long-distance axonal transport is critical to the maintenance and function of neurons. Robust transport is ensured by the coordinated activities of multiple molecular motors acting in a team. Conventional live-cell imaging techniques used in axonal transport studies detect this activity by visualizing the translational dynamics of a cargo. However, translational measurements are insensitive to torques induced by motor activities. By using gold nanorods and multichannel polarization microscopy, we simultaneously measure the rotational and translational dynamics for thousands of axonally transported endosomes...
March 2018: Science Advances
https://www.readbyqxmd.com/read/29483280/swedish-nerve-growth-factor-mutation-ngf-r100w-defines-a-role-for-trka-and-p75-ntr-in-nociception
#5
Kijung Sung, Luiz F Ferrari, Wanlin Yang, ChiHye Chung, Xiaobei Zhao, Yingli Gu, Suzhen Lin, Kai Zhang, Bianxiao Cui, Matthew L Pearn, Michael T Maloney, William C Mobley, Jon D Levine, Chengbiao Wu
Nerve growth factor (NGF) exerts multiple functions on target neurons throughout development. The recent discovery of a point mutation leading to a change from arginine to tryptophan at residue 100 in the mature NGFβ sequence (NGFR100W ) in patients with hereditary sensory and autonomic neuropathy type V (HSAN V) made it possible to distinguish the signaling mechanisms that lead to two functionally different outcomes of NGF: trophic versus nociceptive. We performed extensive biochemical, cellular, and live-imaging experiments to examine the binding and signaling properties of NGFR100W Our results show that, similar to the wild-type NGF (wtNGF), the naturally occurring NGFR100W mutant was capable of binding to and activating the TrkA receptor and its downstream signaling pathways to support neuronal survival and differentiation...
April 4, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29083144/enhanced-cell-chip-coupling-by-rapid-femtosecond-laser-patterning-of-soft-pedot-pss-biointerfaces
#6
Francesca Santoro, Yoeri van de Burgt, Scott Tom Keene, Bianxiao Cui, Alberto Salleo
Interfacing soft materials with biological systems holds considerable promise for both biosensors and recording live cells. However, the interface between cells and organic substrates is not well studied, despite its crucial role in the effectiveness of the device. Furthermore, well-known cell adhesion enhancers, such as microgrooves, have not been implemented on these surfaces. Here, we present a nanoscale characterization of the cell-substrate interface for 3D laser-patterned organic electrodes by combining electrochemical impedance spectroscopy (EIS) and scanning electron microscopy/focused ion beam (SEM/FIB)...
November 2, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28929741/visible-light-neural-stimulation-on-graphitic-carbon-nitride-graphene-photocatalytic-fibers
#7
Zhongyang Zhang, Ruodan Xu, Zegao Wang, Mingdong Dong, Bianxiao Cui, Menglin Chen
Light stimulation allows remote and spatiotemporally accurate operation that has been applied as effective, noninvasive means of therapeutic interventions. Here, visible-light neural stimulation of graphitic carbon nitride (g-C3N4), an emerging photocatalyst with visible-light optoelectronic conversion, was for the first time investigated. Specifically, g-C3N4 was combined with graphene oxide (GO) in a three-dimensional manner on the surfaces of electrospun polycaprolactone/gelatin (PG) fibers and functioned as a biocompatible interface for visible-light stimulating neuronal differentiation...
October 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28916751/understanding-cry2-interactions-for-optical-control-of-intracellular-signaling
#8
Liting Duan, Jen Hope, Qunxiang Ong, Hsin-Ya Lou, Namdoo Kim, Comfrey McCarthy, Victor Acero, Michael Z Lin, Bianxiao Cui
Arabidopsis cryptochrome 2 (CRY2) can simultaneously undergo light-dependent CRY2-CRY2 homo-oligomerization and CRY2-CIB1 hetero-dimerization, both of which have been widely used to optically control intracellular processes. Applications using CRY2-CIB1 interaction desire minimal CRY2 homo-oligomerization to avoid unintended complications, while those utilizing CRY2-CRY2 interaction prefer robust homo-oligomerization. However, selecting the type of CRY2 interaction has not been possible as the molecular mechanisms underlying CRY2 interactions are unknown...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28682058/revealing-the-cell-material-interface-with-nanometer-resolution-by-focused-ion-beam-scanning-electron-microscopy
#9
Francesca Santoro, Wenting Zhao, Lydia-Marie Joubert, Liting Duan, Jan Schnitker, Yoeri van de Burgt, Hsin-Ya Lou, Bofei Liu, Alberto Salleo, Lifeng Cui, Yi Cui, Bianxiao Cui
The interface between cells and nonbiological surfaces regulates cell attachment, chronic tissue responses, and ultimately the success of medical implants or biosensors. Clinical and laboratory studies show that topological features of the surface profoundly influence cellular responses; for example, titanium surfaces with nano- and microtopographical structures enhance osteoblast attachment and host-implant integration as compared to a smooth surface. To understand how cells and tissues respond to different topographical features, it is of critical importance to directly visualize the cell-material interface at the relevant nanometer length scale...
August 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28581510/nanoscale-manipulation-of-membrane-curvature-for-probing-endocytosis-in-live-cells
#10
Wenting Zhao, Lindsey Hanson, Hsin-Ya Lou, Matthew Akamatsu, Praveen D Chowdary, Francesca Santoro, Jessica R Marks, Alexandre Grassart, David G Drubin, Yi Cui, Bianxiao Cui
Clathrin-mediated endocytosis (CME) involves nanoscale bending and inward budding of the plasma membrane, by which cells regulate both the distribution of membrane proteins and the entry of extracellular species. Extensive studies have shown that CME proteins actively modulate the plasma membrane curvature. However, the reciprocal regulation of how the plasma membrane curvature affects the activities of endocytic proteins is much less explored, despite studies suggesting that membrane curvature itself can trigger biochemical reactions...
August 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28059522/dual-functional-lipid-coating-for-the-nanopillar-based-capture-of-circulating-tumor-cells-with-high-purity-and-efficiency
#11
Hsin-Ya Lou, Wenting Zhao, Lindsey Hanson, Connie Zeng, Yi Cui, Bianxiao Cui
Clinical studies of circulating tumor cells (CTC) have stringent demands for high capture purity and high capture efficiency. Nanostructured surfaces have been shown to significantly increase the capture efficiency yet suffer from low capture purity. Here we introduce a dual-functional lipid coating on nanostructured surfaces. The lipid coating serves both as an effective passivation layer that helps prevent nonspecific cell adhesion and as a functionalized layer for antibody-based specific cell capture. In addition, the fluidity of lipid bilayers enables antibody clustering that enhances the cell-surface interaction for efficient cell capture...
January 31, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/27982125/imaging-electric-field-dynamics-with-graphene-optoelectronics
#12
Jason Horng, Halleh B Balch, Allister F McGuire, Hsin-Zon Tsai, Patrick R Forrester, Michael F Crommie, Bianxiao Cui, Feng Wang
The use of electric fields for signalling and control in liquids is widespread, spanning bioelectric activity in cells to electrical manipulation of microstructures in lab-on-a-chip devices. However, an appropriate tool to resolve the spatio-temporal distribution of electric fields over a large dynamic range has yet to be developed. Here we present a label-free method to image local electric fields in real time and under ambient conditions. Our technique combines the unique gate-variable optical transitions of graphene with a critically coupled planar waveguide platform that enables highly sensitive detection of local electric fields with a voltage sensitivity of a few microvolts, a spatial resolution of tens of micrometres and a frequency response over tens of kilohertz...
December 16, 2016: Nature Communications
https://www.readbyqxmd.com/read/27941784/control-of-cerebral-ischemia-with-magnetic-nanoparticles
#13
Jie-Min Jia, Praveen D Chowdary, Xiaofei Gao, Bo Ci, Wenjun Li, Aditi Mulgaonkar, Erik J Plautz, Gedaa Hassan, Amit Kumar, Ann M Stowe, Shao-Hua Yang, Wei Zhou, Xiankai Sun, Bianxiao Cui, Woo-Ping Ge
The precise manipulation of microcirculation in mice can facilitate mechanistic studies of brain injury and repair after ischemia, but this manipulation remains a technical challenge, particularly in conscious mice. We developed a technology that uses micromagnets to induce aggregation of magnetic nanoparticles to reversibly occlude blood flow in microvessels. This allowed induction of ischemia in a specific cortical region of conscious mice of any postnatal age, including perinatal and neonatal stages, with precise spatiotemporal control but without surgical intervention of the skull or artery...
February 2017: Nature Methods
https://www.readbyqxmd.com/read/27082641/the-timing-of-raf-erk-and-akt-activation-in-protecting-pc12-cells-against-oxidative-stress
#14
Qunxiang Ong, Shunling Guo, Liting Duan, Kai Zhang, Eleanor Ann Collier, Bianxiao Cui
Acute brain injuries such as ischemic stroke or traumatic brain injury often cause massive neural death and irreversible brain damage with grave consequences. Previous studies have established that a key participant in the events leading to neural death is the excessive production of reactive oxygen species. Protecting neuronal cells by activating their endogenous defense mechanisms is an attractive treatment strategy for acute brain injuries. In this work, we investigate how the precise timing of the Raf/ERK and the AKT pathway activation affects their protective effects against oxidative stress...
2016: PloS One
https://www.readbyqxmd.com/read/26656461/nanoparticle-assisted-optical-tethering-of-endosomes-reveals-the-cooperative-function-of-dyneins-in-retrograde-axonal-transport
#15
Praveen D Chowdary, Daphne L Che, Luke Kaplan, Ou Chen, Kanyi Pu, Moungi Bawendi, Bianxiao Cui
Dynein-dependent transport of organelles from the axon terminals to the cell bodies is essential to the survival and function of neurons. However, quantitative knowledge of dyneins on axonal organelles and their collective function during this long-distance transport is lacking because current technologies to do such measurements are not applicable to neurons. Here, we report a new method termed nanoparticle-assisted optical tethering of endosomes (NOTE) that made it possible to study the cooperative mechanics of dyneins on retrograde axonal endosomes in live neurons...
December 10, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26528790/a-close-look-at-axonal-transport-cargos-slow-down-when-crossing-stationary-organelles
#16
Daphne L Che, Praveen D Chowdary, Bianxiao Cui
The bidirectional transport of cargos along the thin axon is fundamental for the structure, function and survival of neurons. Defective axonal transport has been linked to the mechanism of neurodegenerative diseases. In this paper, we study the effect of the local axonal environment to cargo transport behavior in neurons. Using dual-color fluorescence imaging in microfluidic neuronal devices, we quantify the transport dynamics of cargos when crossing stationary organelles such as non-moving endosomes and stationary mitochondria in the axon...
January 1, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26472906/a-skin-inspired-organic-digital-mechanoreceptor
#17
Benjamin C-K Tee, Alex Chortos, Andre Berndt, Amanda Kim Nguyen, Ariane Tom, Allister McGuire, Ziliang Carter Lin, Kevin Tien, Won-Gyu Bae, Huiliang Wang, Ping Mei, Ho-Hsiu Chou, Bianxiao Cui, Karl Deisseroth, Tse Nga Ng, Zhenan Bao
Human skin relies on cutaneous receptors that output digital signals for tactile sensing in which the intensity of stimulation is converted to a series of voltage pulses. We present a power-efficient skin-inspired mechanoreceptor with a flexible organic transistor circuit that transduces pressure into digital frequency signals directly. The output frequency ranges between 0 and 200 hertz, with a sublinear response to increasing force stimuli that mimics slow-adapting skin mechanoreceptors. The output of the sensors was further used to stimulate optogenetically engineered mouse somatosensory neurons of mouse cortex in vitro, achieving stimulated pulses in accordance with pressure levels...
October 16, 2015: Science
https://www.readbyqxmd.com/read/26216953/activity-dependent-bdnf-release-via-endocytic-pathways-is-regulated-by-synaptotagmin-6-and-complexin
#18
Yu-Hui Wong, Chia-Ming Lee, Wenjun Xie, Bianxiao Cui, Mu-ming Poo
Brain-derived neurotrophic factor (BDNF) is known to modulate synapse development and plasticity, but the source of synaptic BDNF and molecular mechanisms regulating BDNF release remain unclear. Using exogenous BDNF tagged with quantum dots (BDNF-QDs), we found that endocytosed BDNF-QDs were preferentially localized to postsynaptic sites in the dendrite of cultured hippocampal neurons. Repetitive neuronal spiking induced the release of BDNF-QDs at these sites, and this process required activation of glutamate receptors...
August 11, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26039170/retrograde-ngf-axonal-transport-motor-coordination-in-the-unidirectional-motility-regime
#19
Praveen D Chowdary, Daphne L Che, Kai Zhang, Bianxiao Cui
We present a detailed motion analysis of retrograde nerve growth factor (NGF) endosomes in axons to show that mechanical tugs-of-war and intracellular motor regulation are complimentary features of the near-unidirectional endosome directionality. We used quantum dots to fluorescently label NGF and acquired trajectories of retrograde quantum-dot-NGF-endosomes with <20-nm accuracy at 32 Hz in microfluidic neuron cultures. Using a combination of transient motion analysis and Bayesian parsing, we partitioned the trajectories into sustained periods of retrograde (dynein-driven) motion, constrained pauses, and brief anterograde (kinesin-driven) reversals...
June 2, 2015: Biophysical Journal
https://www.readbyqxmd.com/read/25985220/the-dual-characteristics-of-light-induced-cryptochrome-2-homo-oligomerization-and-heterodimerization-for-optogenetic-manipulation-in-mammalian-cells
#20
Daphne L Che, Liting Duan, Kai Zhang, Bianxiao Cui
The photoreceptor cryptochrome 2 (CRY2) has become a powerful optogenetic tool that allows light-inducible manipulation of various signaling pathways and cellular processes in mammalian cells with high spatiotemporal precision and ease of application. However, it has also been shown that the behavior of CRY2 under blue light is complex, as the photoexcited CRY2 can both undergo homo-oligomerization and heterodimerization by binding to its dimerization partner CIB1. To better understand the light-induced CRY2 activities in mammalian cells, this article systematically characterizes CRY2 homo-oligomerization in different cellular compartments, as well as how CRY2 homo-oligomerization and heterodimerization activities affect each other...
October 16, 2015: ACS Synthetic Biology
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