Suzanne Elsasser, Lisa P Elia, Richard I Morimoto, Evan T Powers, Suzanne Elsasser, Daniel Finley, Beatrice Costa, Maher Budron, Zachary Tokuno, Shijie Wang, Rajshri G Iyer, Bianca Barth, Eric Mockler, Lisa P Elia, Steve Finkbeiner, Jason E Gestwicki, Reese A K Richardson, Thomas Stoeger, Richard I Morimoto, Ee Phie Tan, Qiang Xiao, Christian M Cole, Lyn E A Massey, Dan Garza, Evan T Powers, Jeffery W Kelly, T Kelly Rainbolt, Ching-Chieh Chou, Vincent B Masto, Judith Frydman, Ralph A Nixon
The condition of having a healthy, functional proteome is known as protein homeostasis, or proteostasis. Establishing and maintaining proteostasis is the province of the proteostasis network, approximately 2,700 components that regulate protein synthesis, folding, localization, and degradation. The proteostasis network is a fundamental entity in biology that is essential for cellular health and has direct relevance to many diseases of protein conformation. However, it is not well defined or annotated, which hinders its functional characterization in health and disease...
March 24, 2023: bioRxiv