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https://www.readbyqxmd.com/read/29773662/validation-of-the-16-gene-recurrence-score-in-patients-with-locoregional-high-risk-renal-cell-carcinoma-from-a-phase-3-trial-of-adjuvant-sunitinib
#1
Brian I Rini, Bernard Escudier, Jean-Francois Martini, Ahmed Magheli, Christer Svedman, Margarita Lopatin, Dejan Knezevic, Audrey D Goddard, Phillip G Febbo, Rachel Li, Xun Lin, Olga Valota, Michael Staehler, Robert J Motzer, Alain Ravaud
PURPOSE: Adjuvant sunitinib prolonged disease-free survival (DFS) (hazard ratio [HR] 0.76) in patients with locoregional high-risk renal cell carcinoma (RCC) in the S-TRAC trial (ClinicalTrials.gov NCT00375674). The 16-gene Recurrence Score (RS) assay was previously developed and validated to estimate risk for disease recurrence in patients with RCC post-nephrectomy. This analysis further validated the prognostic value of RS assay in patients from S-TRAC and explored association of RS results with prediction of sunitinib benefit...
May 17, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29773572/hemostatic-efficacy-of-pathogen-inactivated-versus-untreated-platelets-a-randomized-controlled-trial
#2
Pieter F van der Meer, Paula F Ypma, Nan van Geloven, Joost A van Hilten, Rinie J van Wordragen-Vlaswinkel, Okke Eissen, Jaap J Zwaginga, MIchael Trus, Erik A M Beckers, Peter Te Boekhorst, Alan Tinmouth, Yulia Lin, Cyrus Hsia, David Lee, Philip J Norris, Raymond P Goodrich, Anneke Brand, Tor Hervig, Nancy M Heddle, Johanna G van der Bom, Jean-Louis H Kerkhoffs
Pathogen inactivation of platelet concentrates reduces the risk of blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen inactivated platelets using riboflavin and ultraviolet B illumination technology (intervention) compared to standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocytopenia. The primary outcome parameter was the proportion of transfusion treatment periods in which the patient had grade 2 or higher bleeding as defined by World Health Organization (WHO) criteria...
May 17, 2018: Blood
https://www.readbyqxmd.com/read/29772881/geographic-access-to-radiation-therapy-facilities-and-disparities-of-early-stage-breast-cancer-treatment
#3
Yan Lin, Michael C Wimberly, Patricia Da Rosa, Joseph Hoover, William F Athas
Few studies of breast cancer treatment have focused on the Northern Plains of the United States, an area with a high mastectomy rate. This study examined the association between geographic access to radiation therapy facilities and receipt of breast cancer treatments among early-stage breast cancer patients in South Dakota. Based on 4,209 early-stage breast cancer patients diagnosed between 2001 and 2012 in South Dakota, the study measured geographic proximity to radiation therapy facilities using the shortest travel time for patients to the closest radiation therapy facility...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29771785/cutaneous-melanoma-risk-among-people-with-hiv-in-the-united-states-and-canada
#4
Elizabeth L Yanik, Raúl U Hernández-Ramírez, Li Qin, Haiqun Lin, Wendy Leyden, Romain S Neugebauer, Michael A Horberg, Richard D Moore, W Christopher Mathews, Amy C Justice, Nancy A Hessol, Angel M Mayor, M John Gill, John T Brooks, Jing Sun, Keri N Althoff, Eric A Engels, Michael J Silverberg, Robert Dubrow
BACKGROUND: Cutaneous melanoma incidence may be modestly elevated in people with HIV (PWH) versus people without HIV. However, little is known about the relationship of immunosuppression, HIV replication, and antiretroviral treatment (ART) with melanoma risk. METHODS: PWH of white race in the North American AIDS Cohort Collaboration on Research and Design were included. A standardized incidence ratio (SIR) was calculated comparing risk with the white general population, standardizing by age, sex, and calendar period...
April 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29769725/mxra8-is-a-receptor-for-multiple-arthritogenic-alphaviruses
#5
Rong Zhang, Arthur S Kim, Julie M Fox, Sharmila Nair, Katherine Basore, William B Klimstra, Rebecca Rimkunas, Rachel H Fong, Hueylie Lin, Subhajit Poddar, James E Crowe, Benjamin J Doranz, Daved H Fremont, Michael S Diamond
Arthritogenic alphaviruses comprise a group of enveloped RNA viruses that are transmitted to humans by mosquitoes and cause debilitating acute and chronic musculoskeletal disease 1 . The host factors required for alphavirus entry remain poorly characterized 2 . Here we use a genome-wide CRISPR-Cas9-based screen to identify the cell adhesion molecule Mxra8 as an entry mediator for multiple emerging arthritogenic alphaviruses, including chikungunya, Ross River, Mayaro and O'nyong nyong viruses. Gene editing of mouse Mxra8 or human MXRA8 resulted in reduced levels of viral infection of cells and, reciprocally, ectopic expression of these genes resulted in increased infection...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769722/bystander-cd8-t-cells-are-abundant-and-phenotypically-distinct-in-human-tumour-infiltrates
#6
Yannick Simoni, Etienne Becht, Michael Fehlings, Chiew Yee Loh, Si-Lin Koo, Karen Wei Weng Teng, Joe Poh Sheng Yeong, Rahul Nahar, Tong Zhang, Hassen Kared, Kaibo Duan, Nicholas Ang, Michael Poidinger, Yin Yeng Lee, Anis Larbi, Alexis J Khng, Emile Tan, Cherylin Fu, Ronnie Mathew, Melissa Teo, Wan Teck Lim, Chee Keong Toh, Boon-Hean Ong, Tina Koh, Axel M Hillmer, Angela Takano, Tony Kiat Hon Lim, Eng Huat Tan, Weiwei Zhai, Daniel S W Tan, Iain Beehuat Tan, Evan W Newell
Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that can lead to marked and sustained clinical responses, but only in some patients and cancer types1-4 . Patients and tumours may respond unpredictably to immunotherapy partly owing to heterogeneity of the immune composition and phenotypic profiles of tumour-infiltrating lymphocytes (TILs) within individual tumours and between patients5,6 . Although there is evidence that tumour-mutation-derived neoantigen-specific T cells play a role in tumour control2,4,7-10 , in most cases the antigen specificities of phenotypically diverse tumour-infiltrating T cells are largely unknown...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769372/iglon5-mediated-neurodegeneration-is-a-differential-diagnosis-of-cns-whipple-disease
#7
Hugo Morales-Briceño, Belinda Cruse, Alessandro F Fois, Ming-Wei Lin, Jocelyn Jiang, Dev Banerjee, Ron Grunstein, Winny Varikatt, Michael Rodriguez, Claire Shepherd, Victor S C Fung
No abstract text is available yet for this article.
May 16, 2018: Neurology
https://www.readbyqxmd.com/read/29769083/racial-ethnic-disparities-among-asian-americans-in-inpatient-acute-myocardial-infarction-mortality-in-the-united-states
#8
Eun Ji Kim, Nancy R Kressin, Michael K Paasche-Orlow, Lenny Lopez, Jennifer E Rosen, Mengyun Lin, Amresh D Hanchate
BACKGROUND: Acute myocardial infarction (AMI) is a common high-risk disease with inpatient mortality of 5% nationally. But little is known about this outcome among Asian Americans (Asians), a fast growing racial/ethnic minority in the country. The objectives of the study are to obtain near-national estimates of differences in AMI inpatient mortality between minorities (including Asians) and non-Hispanic Whites and identify comorbidities and sociodemographic characteristics associated with these differences...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29768165/human-innate-lymphoid-cell-subsets-possess-tissue-type-based-heterogeneity-in-phenotype-and-frequency
#9
Yannick Simoni, Michael Fehlings, Henrik N Kløverpris, Naomi McGovern, Si-Lin Koo, Chiew Yee Loh, Shawn Lim, Ayako Kurioka, Joannah R Fergusson, Choong-Leong Tang, Ming Hian Kam, Koh Dennis, Tony Kiat Hon Lim, Alexander Chung Yaw Fui, Chan Weng Hoong, Jerry Kok Yen Chan, Maria Curotto de Lafaille, Sriram Narayanan, Sonia Baig, Muhammad Shabeer, Sue-Anne Ee Shiow Toh, Henry Kun Kiaang Tan, Rosslyn Anicete, Eng-Huat Tan, Angela Takano, Paul Klenerman, Alasdair Leslie, Daniel S W Tan, Iain Beehuat Tan, Florent Ginhoux, Evan W Newell
No abstract text is available yet for this article.
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29767502/low-voltage-solution-processed-hybrid-light-emitting-transistors
#10
Mujeeb Ullah Chaudhry, Kornelius Tetzner, Yen-Hung Lin, Sungho Nam, Christopher Pearson, Chris Groves, Michael C Petty, Thomas D Anthopoulos, Donal D C Bradley
We report the development of low operating voltages in inorganic-organic hybrid light-emitting transistors (HLETs) based on solution-processed ZrOx gate dielectric and a hybrid multilayer channel consisting of the heterojunction In3 O2 /ZnO and the organic polymer 'Super Yellow' acting as n- and p-channel/emissive layers, respectively. Resulting HLETs operate at the lowest voltages reported to-date (<10 V) and combine high electron mobility (22 cm2 /Vs) with appreciable current on/off ratios (≈103 ) and an external quantum efficiency of 2×10-2 % at 700 cd/m2 ...
May 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29766771/five-year-risk-of-stroke-after-tia-or-minor-ischemic-stroke
#11
Pierre Amarenco, Philippa C Lavallée, Linsay Monteiro Tavares, Julien Labreuche, Gregory W Albers, Halim Abboud, Sabrina Anticoli, Heinrich Audebert, Natan M Bornstein, Louis R Caplan, Manuel Correia, Geoffrey A Donnan, José M Ferro, Fernando Gongora-Rivera, Wolfgang Heide, Michael G Hennerici, Peter J Kelly, Michal Král, Hsiu-Fen Lin, Carlos Molina, Jong Moo Park, Francisco Purroy, Peter M Rothwell, Tomas Segura, David Školoudík, P Gabriel Steg, Pierre-Jean Touboul, Shinichiro Uchiyama, Éric Vicaut, Yongjun Wang, Lawrence K S Wong
Background After a transient ischemic attack (TIA) or minor stroke, the long-term risk of stroke and other vascular events is not well known. In this follow-up to a report on 1-year outcomes from a registry of TIA clinics in 21 countries that enrolled 4789 patients with a TIA or minor ischemic stroke from 2009 through 2011, we examined the 5-year risk of stroke and vascular events. Methods We evaluated patients who had had a TIA or minor stroke within 7 days before enrollment in the registry. Among 61 sites that participated in the 1-year outcome study, we selected 42 sites that had follow-up data on more than 50% of their enrolled patients at 5 years...
May 16, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29762290/what-s-new-in-foot-and-ankle-surgery
#12
Sheldon S Lin, Omkar Baxi, Michael Yeranosian
No abstract text is available yet for this article.
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29760096/an-operando-x-ray-diffraction-study-of-chloroaluminate-anion-graphite-intercalation-in-aluminum-batteries
#13
Chun-Jern Pan, Chunze Yuan, Guanzhou Zhu, Qian Zhang, Chen-Jui Huang, Meng-Chang Lin, Michael Angell, Bing-Joe Hwang, Payam Kaghazchi, Hongjie Dai
We investigated rechargeable aluminum (Al) batteries composed of an Al negative electrode, a graphite positive electrode, and an ionic liquid (IL) electrolyte at temperatures down to -40 °C. The reversible battery discharge capacity at low temperatures could be superior to that at room temperature. In situ/operando electrochemical and synchrotron X-ray diffraction experiments combined with theoretical modeling revealed stable AlCl4 - /graphite intercalation up to stage 3 at low temperatures, whereas intercalation was reversible up to stage 4 at room temperature (RT)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759543/long-term-outcomes-of-catheter-ablation-of-electrical-storm-in-nonischemic-dilated-cardiomyopathy-compared-with-ischemic-cardiomyopathy
#14
Daniele Muser, Jackson J Liang, Rajeev K Pathak, Silvia Magnani, Simon A Castro, Tatsuya Hayashi, Fermin C Garcia, Gregory E Supple, Michael P Riley, David Lin, Sanjay Dixit, Erica S Zado, David S Frankel, David J Callans, Francis E Marchlinski, Pasquale Santangeli
OBJECTIVES: The goal of this study was to determine the long-term outcomes of catheter ablation (CA) of electrical storm in patients with nonischemic dilated cardiomyopathy (NIDCM) compared with patients with ischemic cardiomyopathy (ICM). BACKGROUND: CA of ventricular tachycardia (VT) electrical storm has been shown to improve VT-free survival in patients with ICM. Data on the outcomes of CA of electrical storm in patients with NIDCM are insufficient. METHODS: The study included 267 consecutive patients with NIDCM (n = 71; ejection fraction 32 ± 14%) and ICM (n = 196; ejection fraction 28 ± 12%)...
July 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29755127/a-novel-long-non-coding-rna-linc-znf469-3-promotes-lung-metastasis-through-mir-574-5p-zeb1-axis-in-triple-negative-breast-cancer
#15
Po-Shun Wang, Cheng-Han Chou, Cheng-Han Lin, Yun-Chin Yao, Hui-Chuan Cheng, Hao-Yi Li, Yu-Chung Chuang, Chia-Ning Yang, Luo-Ping Ger, Yu-Chia Chen, Forn-Chia Lin, Tang-Long Shen, Michael Hsiao, Pei-Jung Lu
Triple-negative breast cancer (TNBC) patients usually lead to poor prognosis and survival because of metastasis. The major sites for TNBC metastasis include the lungs, brain, liver, and bone. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides and have been reported as important regulators in BC metastasis. However, the underlying mechanisms for lncRNAs regulating TNBC metastasis are not fully understood. Here we found that linc-ZNF469-3 was highly expressed in lung-metastatic LM2-4175 TNBC cells and overexpression of linc-ZNF469-3 enhanced invasion ability and stemness properties in vitro and lung metastasis in vivo...
May 14, 2018: Oncogene
https://www.readbyqxmd.com/read/29754189/consensus-on-best-practice-standards-for-fracture-liaison-service-in-the-asia-pacific-region
#16
Ding-Cheng Derrick Chan, Lo-Yu Chang, Kristina E Akesson, Paul Mitchell, Chung-Hwan Chen, E Michael Lewiecki, Joon Kiong Lee, Tang Ching Lau, Thawee Songpatanasilp, Kin Bong Lee, Kwang Joon Kim, Jung-Fu Chen, Ko-En Huang, Yih-Lan Gau, Yin-Fan Chang, Peter Ebeling, Weibo Xia, Wei Yu, Atsushi Suzuki, Fen Lee Hew, Leilani B Mercado-Asis, Yoon-Sok Chung, Keh-Sung Tsai, Gau-Tyan Lin, Rong-Sen Yang, Chih-Hsing Wu
The Fracture Liaison Service (FLS) Consensus Meeting endorsed by the International Osteoporosis Foundation (IOF), Asian Federation of Osteoporosis Societies (AFOS), and Asia Pacific Osteoporosis Foundation (APOF) was hosted by the Taiwanese Osteoporosis Association on October 14, 2017. International and domestic experts reviewed the 13 Best Practice Framework (BPF) standards and concluded that all standards were generally applicable in the Asia-Pacific region and needed only minor modifications to fit the healthcare settings in the region...
May 12, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29752399/common-coding-variants-in-scn10a-are-associated-with-the-nav1-8-late-current-and-cardiac-conduction
#17
Vincenzo Macri, Jennifer A Brody, Dan E Arking, William J Hucker, Xiaoyan Yin, Honghuang Lin, Robert W Mills, Moritz F Sinner, Steven A Lubitz, Ching-Ti Liu, Alanna C Morrison, Alvaro Alonso, Ning Li, Vadim V Fedorov, Paul M Janssen, Joshua C Bis, Susan R Heckbert, Elena V Dolmatova, Thomas Lumley, Colleen M Sitlani, L Adrienne Cupples, Sara L Pulit, Christopher Newton-Cheh, John Barnard, Jonathan D Smith, David R Van Wagoner, Mina K Chung, Gus J Vlahakes, Christopher J O'Donnell, Jerome I Rotter, Kenneth B Margulies, Michael P Morley, Thomas P Cappola, Emelia J Benjamin, Donna Muzny, Richard A Gibbs, Rebecca D Jackson, Jared W Magnani, Caroline N Herndon, Stephen S Rich, Bruce M Psaty, David J Milan, Eric Boerwinkle, Peter J Mohler, Nona Sotoodehnia, Patrick T Ellinor
BACKGROUND: Genetic variants at the SCN5A / SCN10A locus are strongly associated with electrocardiographic PR and QRS intervals. While SCN5A is the canonical cardiac sodium channel gene, the role of SCN10A in cardiac conduction is less well characterized. METHODS: We sequenced the SCN10A locus in 3699 European-ancestry individuals to identify variants associated with cardiac conduction, and replicated our findings in 21,000 individuals of European ancestry. We examined association with expression in human atrial tissue...
May 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29751164/tracking-antibiotic-resistome-during-wastewater-treatment-using-high-throughput-quantitative-pcr
#18
Xin-Li An, Jian-Qiang Su, Bing Li, Wei-Ying Ouyang, Yi Zhao, Qing-Lin Chen, Li Cui, Hong Chen, Michael R Gillings, Tong Zhang, Yong-Guan Zhu
Wastewater treatment plants (WWTPs) contain diverse antibiotic resistance genes (ARGs), and thus are considered as a major pathway for the dissemination of these genes into the environments. However, comprehensive evaluations of ARGs dynamic during wastewater treatment process lack extensive investigations on a broad spectrum of ARGs. Here, we investigated the dynamics of ARGs and bacterial community structures in 114 samples from eleven Chinese WWTPs using high-throughput quantitative PCR and 16S rRNA-based Illumina sequencing analysis...
May 8, 2018: Environment International
https://www.readbyqxmd.com/read/29750700/assessment-of-a-chemotherapy-response-score-crs-system-for-tubo-ovarian-high-grade-serous-carcinoma-hgsc
#19
Helena M Ditzel, Kyle C Strickland, Emily E Meserve, Elizabeth Stover, Panagiotis A Konstantinopoulos, Ursula A Matulonis, Michael G Muto, Joyce F Liu, Colleen Feltmate, Neil Horowitz, Ross S Berkowitz, Mamta Gupta, Jonathan L Hecht, Douglas I Lin, Kirsten M Jochumsen, William R Welch, Michelle S Hirsch, Bradley J Quade, Kenneth R Lee, Christopher P Crum, George L Mutter, Marisa R Nucci, Brooke E Howitt
A chemotherapy response score (CRS) system was recently described to assess the histopathologic response and prognosis of patients with tubo-ovarian high-grade serous carcinoma (HGSC) receiving neoadjuvant chemotherapy. The current study was performed as an independent assessment of this CRS system. We retrospectively identified advanced stage HGSC patients who received neoadjuvant chemotherapy and underwent interval debulking. If available, a hemotoxylin and eosin slide from the omentum and the adnexa was selected for the study...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29748278/recent-asian-origin-of-chytrid-fungi-causing-global-amphibian-declines
#20
Simon J O'Hanlon, Adrien Rieux, Rhys A Farrer, Gonçalo M Rosa, Bruce Waldman, Arnaud Bataille, Tiffany A Kosch, Kris A Murray, Balázs Brankovics, Matteo Fumagalli, Michael D Martin, Nathan Wales, Mario Alvarado-Rybak, Kieran A Bates, Lee Berger, Susanne Böll, Lola Brookes, Frances Clare, Elodie A Courtois, Andrew A Cunningham, Thomas M Doherty-Bone, Pria Ghosh, David J Gower, William E Hintz, Jacob Höglund, Thomas S Jenkinson, Chun-Fu Lin, Anssi Laurila, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Frank Pasmans, Dirk S Schmeller, Benedikt R Schmidt, Jennifer M G Shelton, Lee F Skerratt, Freya Smith, Claudio Soto-Azat, Matteo Spagnoletti, Giulia Tessa, Luís Felipe Toledo, Andrés Valenzuela-Sánchez, Ruhan Verster, Judit Vörös, Rebecca J Webb, Claudia Wierzbicki, Emma Wombwell, Kelly R Zamudio, David M Aanensen, Timothy Y James, M Thomas P Gilbert, Ché Weldon, Jaime Bosch, François Balloux, Trenton W J Garner, Matthew C Fisher
Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis , a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, Bd ASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing...
May 11, 2018: Science
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