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JOURNAL ARTICLE
Michihisa Umetsu, Masayuki Hirokawa, Eri Fukaya, Eiichi Teshima, Hitoshi Kusagawa, Toshiya Nishibe, Hiroko Nemoto, Makoto Mo, Tomohiro Ogawa
Objective: Cyanoacrylate closure (CAC) is a minimally invasive technique for the treatment of varicose veins. A recent paper reported serious adverse events (AEs) associated with this use. This triggered an urgent survey to determine the incidence of AEs in Japan. Methods: The CAC-AE survey was sent to all 1,030 institutions authorized for CAC treatments. Cases performed between January 2020 and October 2023 were surveyed. Data on serious AEs and mortality were collected. Results: There were 623 surveys returned...
March 25, 2024: Annals of Vascular Diseases
#2
JOURNAL ARTICLE
Ayana Suzuki, Mitsuyoshi Hirokawa, Izumi Otsuka, Akihiro Miya, Akira Miyauchi, Takashi Akamizu
Papillary thyroid carcinoma (PTC) with marked cystic formation (CPTC) is not a subtype of PTC, and its clinical characteristics have not been fully investigated. This study aimed to clarify the clinical and pathological characteristics of CPTC and propose important indicators for its clinical management. 33 CPTC nodules with cystic areas occupying >50% of their volume were examined. Two matched controls (AC) were prepared, one with tumor diameter matched for whole tumor diameter (WTD) of CPTCs (WTD-MC) and the other with tumor diameter matched for solid area diameter (SAD) of CPTCs...
April 1, 2024: Endocrine Connections
#3
JOURNAL ARTICLE
A novel in-frame deletion in KIF5C gene causes infantile onset epilepsy and psychomotor retardation.
Santasree Banerjee, Qiang Zhao, Bo Wang, Jiale Qin, Xin Yuan, Ziwei Lou, Weizeng Zheng, Huanguo Li, Xiaojun Wang, Xiawei Cheng, Yu Zhu, Fan Lin, Fan Yang, Junyu Xu, Anjana Munshi, Parimal Das, Yuanfeng Zhou, Kausik Mandal, Yi Wang, Muhammad Ayub, Nobutaka Hirokawa, Yongmei Xi, Guangfu Chen, Chen Li
Motor proteins, encoded by Kinesin superfamily ( KIF ) genes, are critical for brain development and plasticity. Increasing studies reported KIF 's roles in neurodevelopmental disorders. Here, a 6 years and 3 months-old Chinese boy with markedly symptomatic epilepsy, intellectual disability, brain atrophy, and psychomotor retardation was investigated. His parents and younger sister were phenotypically normal and had no disease-related family history. Whole exome sequencing identified a novel heterozygous in-frame deletion (c...
April 2024: MedComm
#4
JOURNAL ARTICLE
Kazutaka Nanba, Amy R Blinder, Aaron M Udager, Yuusuke Hirokawa, Takayoshi Miura, Hiroshi Okuno, Koki Moriyoshi, Yuto Yamazaki, Hironobu Sasano, Akihiro Yasoda, Noriko Satoh-Asahara, William E Rainey, Tetsuya Tagami
Double somatic mutations in CTNNB1 and GNA11/Q have recently been identified in a small subset of aldosterone-producing adenomas (APAs). As a possible pathogenesis of APA due to these mutations, an association with pregnancy, menopause, or puberty has been proposed. However, because of its rarity, characteristics of APA with these mutations have not been well characterized. A 46-year-old Japanese woman presented with hypertension and hypokalemia. She had two pregnancies in the past but had no history of pregnancy-induced hypertension...
2024: Frontiers in Endocrinology
#5
JOURNAL ARTICLE
Ryota Moriuchi, Rion Sano, Shuma Fujii, Yuito Suzuki, Miyune Makita, Yo Kawashima, Takumi Shirakawa, Renki Shindo, Tatsumi Shinkai, Kaede Miura, Moka Hirose, Momiji Nakajima, Asahi Kurokawa, Rituparna Chetia, Chiharu Hirokawa, Tomoko Suzuki, Yukiko Ito, Hiroki Murano, Hideo Dohra, Naoto Ogawa, Yu Kanesaki
Paraburkholderia sp. strain 22B1P utilizes 3-chlorobenzoate as a carbon source. Complete genome sequencing of strain 22B1P revealed two chromosomes and two plasmids. The genes involved in the conversion of 3-chlorobenzoate to 3-chlorocatechol and those involved in the conversion of 3-chlorocatechol to 3-oxoadipate were located on chromosomes 2 and 1, respectively.
March 15, 2024: Microbiology Resource Announcements
#6
JOURNAL ARTICLE
Chankyung Kim, Shipra Agarwal, Andrey Bychkov, Jen-Fan Hang, Agnes Stephanie Harahap, Mitsuyoshi Hirokawa, Kennichi Kakudo, Somboon Keelawat, Chih-Yi Liu, Zhiyan Liu, Truong Phan-Xuan Nguyen, Chanchal Rana, Huy Gia Vuong, Yun Zhu, Chan Kwon Jung
Differentiating BRAF V600E- and RAS-altered encapsulated follicular-patterned thyroid tumors based on morphology remains challenging. This study aimed to validate an 8-score scale nuclear scoring system and investigate the importance of nuclear pseudoinclusions (NPIs) in aiding this differentiation. A cohort of 44 encapsulated follicular-patterned tumors with varying degrees of nuclear atypia and confirmed BRAF V600E or RAS alterations was studied. Nuclear parameters (area, diameter, and optical density) were analyzed using a deep learning model...
February 16, 2024: Virchows Archiv: An International Journal of Pathology
#7
JOURNAL ARTICLE
Kotaro Sakamoto, Takatsugu Hirokawa
Peptides are mid-size molecules (700-2000 g/mol) and have attracted particular interest as therapeutic modalities as they are superior in controlling protein-protein interactions, a process that is a typical drug target category, compared with small molecules (<500 g/mol). In 2020, we identified KS-58 (1333 g/mol) as a K-Ras(G12D)-inhibitory bicyclic peptide and suggested its cell membrane permeability. However, the membrane permeability mechanism had not been elucidated. In this study, we aim to clarify the mechanism by molecular dynamics (MD) simulations...
February 8, 2024: Bioorganic & Medicinal Chemistry Letters
#8
REVIEW
Tatsuya Tanaka, Fumitaka Yamane, Ryohei Sashida, Yu Hirokawa, Tomihiro Wakamiya, Yuhei Michiwaki, Kazuaki Shimoji, Eiichi Suehiro, Keisuke Onoda, Akira Matsuno, Tadatsugu Morimoto
Spinal dural arteriovenous fistula (SDAVF) is among the most common arterial shunt diseases typically found in middle aged or older men. Herein, we aimed to clarify the reasons for misdiagnoses and delayed diagnoses of SDAVF, determine how these affect prognoses, and establish how they can be prevented. We conducted a PubMed/MEDLINE literature search using "spinal dural arteriovenous fistula", "delayed diagnosis", "late diagnosis", and "misdiagnosis" terms. We identified 18 articles, including 965 SDAVF cases...
January 25, 2024: Journal of Clinical Medicine
#9
JOURNAL ARTICLE
Kazuki Shiotani, Yuta Tanisumi, Yuma Osako, Koshi Murata, Junya Hirokawa, Yoshio Sakurai, Hiroyuki Manabe
Flavor plays a critical role in the pleasure of food. Flavor research has mainly focused on human subjects and revealed that many brain regions are involved in flavor perception. However, animal models for elucidating the mechanisms of neural circuits are lacking. Herein, we demonstrate the use of a novel behavioral task in which mice are capable of flavor detection. When the olfactory pathways of the mice were blocked, they could not perform the task. However, behavioral accuracy was not affected when the gustatory pathway was blocked by benzocaine...
February 16, 2024: IScience
#10
JOURNAL ARTICLE
Yu Hirokawa, Chie Inomoto, Kenichi Oyama, Shigeyuki Tahara, Robert Y Osamura, Takayuki Shiomi, Akira Matsuno
Insulinoma-associated protein 1 (INSM1) is a representative diagnostic marker of neuroendocrine neoplasms (NENs); however, it has not yet been used to diagnose pituitary neuroendocrine tumors (PitNETs), according to the 2022 World Health Organization (WHO) classification of pituitary tumors. This study aimed to examine the expression of INSM1 using immunohistochemistry, in the various cell lineages of PitNET classified by hormone secretion and transcription factor expression. INSM1 expression in PitNETs (different subtypes) and normal pituitary tissues was immunohistochemically assessed...
December 28, 2023: Acta Histochemica et Cytochemica
#11
JOURNAL ARTICLE
Eri Nakadai, Shinji Yanagisawa, Masaaki Kataoka, Masaki Nishimura, Souichi Kobayashi, Akira Okaniwa, Ryuichirou Suda, Sachie Ohno, Ryotarou Teranaka, Hirotoshi Shindo, Tomoya Hirokawa, Shota Hioki, Hidetoshi Ando, Hisashi Kondo, Takashi Kaiho
SUBJECTS: We first reviewed surgical outcomes and pathological findings of 32 patients(laparoscopic group: LDP n=11, open group: ODP n=21)who underwent distal pancreatectomy for pancreatic cancer from January 2018 to October 2022. Then we reviewed long-term outcomes, and recurrence type for 20 patients(LDP: n=5, ODP: n=15)from January 2018 to February 2021. RESULTS: LDP group had significantly longer operation time and less blood loss. There was no difference in length of hospital stay, postoperative complications, number of dissected lymph nodes, positive lymph node metastasis rate, and adjuvant chemotherapy rate...
December 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#12
JOURNAL ARTICLE
Masahiro Koyama, Satoru Muramatsu, Yasuaki Hirokawa, Jidai Iriguchi, Akihito Matsuyama, Yoshiya Inokuchi
Radical cations of dimeric clusters of carbon dioxide/disulfide, [(CX2 )2 ]+• (X = O and S), form strong intracluster bonds through charge resonance (CR) interactions. We herein performed electronic photodissociation spectroscopy of [(CX2 )2 ]+• while regulating the temperature under ambient and cryogenic conditions using a quadrupole ion trap. Both ions exhibited broad band absorption in the near-infrared-visible light region; it is called the "CR band", as a measure of the strength of the CR interaction...
January 31, 2024: Journal of Physical Chemistry Letters
#13
JOURNAL ARTICLE
Mariko Hosozawa, Noriko Cable, Satoyo Ikehara, Yuri Aochi, Kanami Tanigawa, Sachiko Baba, Kumi Hirokawa, Tadashi Kimura, Tomotaka Sobue, Hiroyasu Iso
IMPORTANCE: Women with a high level of autistic traits in the general population may experience larger health disparities during pregnancy, particularly women diagnosed with autism spectrum disorder (ASD), which in turn may be associated with increased risk of adverse birth outcomes. OBJECTIVE: To investigate the association between maternal autistic traits and the risk of adverse birth outcomes in the general population. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included mothers of singletons from a nationwide, multicenter prospective birth cohort, the Japan Environmental Children's Study...
January 2, 2024: JAMA Network Open
#14
JOURNAL ARTICLE
Toshiro Kitagawa, Ko Sasaki, Yuto Fujii, Yuki Ikegami, Fuminari Tatsugami, Kazuo Awai, Yutaka Hirokawa, Yukiko Nakano
PURPOSE: The predictive value of 18 F-sodium fluoride (18 F-NaF) positron emission tomography (PET) in combination with coronary computed tomography (CT) angiography (CCTA) for future coronary events has attracted interest. We evaluated the potential of 18 F-NaF PET/CT following CCTA to predict major coronary events (MACE) during a 5-year follow-up period. METHODS: Forty patients with coronary atherosclerotic lesions detected on CCTA underwent 18 F-NaF PET/CT examination...
December 2023: Journal of Nuclear Cardiology
#15
JOURNAL ARTICLE
Ayana Suzuki, Satoshi Nojima, Shinichiro Tahara, Daisuke Motooka, Masaharu Kohara, Daisuke Okuzaki, Mitsuyoshi Hirokawa, Eiichi Morii
BACKGROUND: Follicular tumors include follicular thyroid adenomas and carcinomas; however, it is difficult to distinguish between the two when the cytology or biopsy material is obtained from a portion of the tumor. The presence or absence of invasion in the resected material is used to differentiate between adenomas and carcinomas, which often results in the unnecessary removal of the adenomas. If nodules that may be follicular thyroid carcinomas are identified preoperatively, active surveillance of other nodules as adenomas is possible, which reduces the risk of surgical complications and the expenses incurred during medical treatment...
January 2024: Journal of Pathology and Translational Medicine
#16
JOURNAL ARTICLE
Kanako C Hatanaka, Kenichi Nakamura, Ryohei Katoh, Koichi Ito, Mitsuyoshi Hirokawa, Akira Miyauchi, Yoshihiro Matsuno, Satoshi Kano, Yui Okada, Joji Mori, Yoichi M Ito, Yutaka Hatanaka
Activating rearranged during transfection (RET) proto-oncogene alterations can be identified using next-generation sequencing (NGS) of tumor DNA/RNA. We assessed factors associated with NGS (Oncomine Dx Target Test [ODxTT]) success for resected thyroid cancer (TC) specimens, including sample age, processing conditions, and DNA/RNA quality. TC samples were from three Japanese hospitals, with sample age <1-<10 years, fixative 10%/15% neutralized buffered formalin (NBF), and fixation time ≤48 h/>48 h-≤72 h...
January 16, 2024: Pathology International
#17
JOURNAL ARTICLE
Kayo Imamura, Ken-Ichi Akagi, Yohei Miyanoiri, Hirokazu Tsujimoto, Takatsugu Hirokawa, Hideo Ashida, Kaori Murakami, Asuka Inoue, Ryoji Suno, Takahisa Ikegami, Naotaka Sekiyama, So Iwata, Takuya Kobayashi, Hidehito Tochio
Orexin neuropeptides have many physiological roles in the sleep-wake cycle, feeding behavior, reward demands, and stress responses by activating cognitive receptors, the orexin receptors (OX1R and OX2R), distributed in the brain. There are only subtle differences between OX1R and OX2R in the orthosteric site, which has hindered the rational development of subtype-selective antagonists. In this study, we utilized solution-state NMR to capture the structural plasticity of OX2R labeled with 13 CH3 -ε-methionine in complex with antagonists...
January 1, 2024: Structure
#18
Direct sac puncture embolization for a left subclavian aneurysm with Marfan syndrome: A case report.
Akemi Ohtani, Masato Saito, Naoki Hirokawa, Hiroki Okuda, Hiroki Sato, Koh-Ichi Sakata
Subclavian artery aneurysms, occasionally related to connective tissue diseases, including Marfan syndrome, are rare and conventionally managed with surgery or endovascular treatment. However, in some cases, both interventions are challenging because of the inability to reach an aneurysm through a safe route or postoperative adhesion. This report describes the case of a 43-year-old patient with a left subclavian artery aneurysm and Marfan syndrome. In this case, the patient's 5 previous surgeries related to Marfan syndrome made surgery and endovascular treatment difficult...
March 2024: Radiology Case Reports
#19
Staci A Sorensen, Nathan W Gouwens, Yun Wang, Matt Mallory, Agata Budzillo, Rachel Dalley, Brian Lee, Olga Gliko, Hsien-Chi Kuo, Xiuli Kuang, Rusty Mann, Leila Ahmadinia, Lauren Alfiler, Fahimeh Baftizadeh, Katherine Baker, Sarah Bannick, Darren Bertagnolli, Kris Bickley, Phil Bohn, Dillan Brown, Jasmine Bomben, Krissy Brouner, Chao Chen, Kai Chen, Maggie Chvilicek, Forrest Collman, Tanya Daigle, Tim Dawes, Rebecca de Frates, Nick Dee, Maxwell DePartee, Tom Egdorf, Laila El-Hifnawi, Rachel Enstrom, Luke Esposito, Colin Farrell, Rohan Gala, Andrew Glomb, Clare Gamlin, Amanda Gary, Jeff Goldy, Hong Gu, Kristen Hadley, Mike Hawrylycz, Alex Henry, Dijon Hill, Karla E Hirokawa, Zili Huang, Katelyn Johnson, Zoe Juneau, Sara Kebede, Lisa Kim, Changkyu Lee, Phil Lesnar, Anan Li, Andrew Glomb, Yaoyao Li, Elizabeth Liang, Katie Link, Michelle Maxwell, Medea McGraw, Delissa A McMillen, Alice Mukora, Lindsay Ng, Thomas Ochoa, Aaron Oldre, Daniel Park, Christina Alice Pom, Zoran Popovich, Lydia Potekhina, Ram Rajanbabu, Shea Ransford, Melissa Reding, Augustin Ruiz, David Sandman, La'Akea Siverts, Kimberly A Smith, Michelle Stoecklin, Josef Sulc, Michael Tieu, Jonathan Ting, Jessica Trinh, Sara Vargas, Dave Vumbaco, Miranda Walker, Micheal Wang, Adrian Wanner, Jack Waters, Grace Williams, Julia Wilson, Wei Xiong, Ed Lein, Jim Berg, Brian Kalmbach, Shenqin Yao, Hui Gong, Qingming Luo, Lydia Ng, Uygar Sümbül, Tim Jarsky, Zizhen Yao, Bosiljka Tasic, Hongkui Zeng
The mammalian brain is composed of diverse neuron types that play different functional roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of transcriptomically-defined cell types, yet cell type definitions that include multiple cellular properties can offer additional insights into a neuron's role in brain circuits. While the Patch-seq method can investigate how transcriptomic properties relate to the local morphological and electrophysiological properties of cell types, linking transcriptomic identities to long-range projections is a major unresolved challenge...
November 26, 2023: bioRxiv
#20
JOURNAL ARTICLE
Samson Koelle, Dana Mastrovito, Jennifer D Whitesell, Karla E Hirokawa, Hongkui Zeng, Marina Meila, Julie A Harris, Stefan Mihalas
The Allen Mouse Brain Connectivity Atlas consists of anterograde tracing experiments targeting diverse structures and classes of projecting neurons. Beyond regional anterograde tracing done in C57BL/6 wild-type mice, a large fraction of experiments are performed using transgenic Cre-lines. This allows access to cell-class-specific whole-brain connectivity information, with class defined by the transgenic lines. However, even though the number of experiments is large, it does not come close to covering all existing cell classes in every area where they exist...
2023: Network Neuroscience
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