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https://www.readbyqxmd.com/read/29313800/kif2a-regulates-the-development-of-dentate-granule-cells-and-postnatal-hippocampal-wiring
#1
Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G Chaudhary, Mohammed H Al-Qahtani, Nobutaka Hirokawa
Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expressed in the hippocampus, in which new neurons are generated throughout an individual's life in established neuronal circuits. In this study, we investigated KIF2A function in the postnatal hippocampus by using tamoxifen-inducible Kif2a conditional knockout (Kif2a-cKO) mice...
January 9, 2018: ELife
https://www.readbyqxmd.com/read/29311502/a-novel-hamster-nonalcoholic-steatohepatitis-model-induced-by-a-high-fat-and-high-cholesterol-diet
#2
Yuta Miyaoka, Denan Jin, Keitaro Tashiro, Shinsuke Masubuchi, Maiko Ozeki, Fumitoshi Hirokawa, Michihiro Hayashi, Shinji Takai, Kazuhisa Uchiyama
Nonalcoholic steatohepatitis (NASH), in which there is steatosis and fibrosis in the liver, is linked to metabolic syndrome and progresses to hepatic cirrhosis. In this study, a novel hamster NASH model derived from metabolic syndrome was made using hamsters. Hamsters were fed a normal or a high-fat and high-cholesterol (HFC) diet for 12 weeks. Body weight and the ratio of liver weight to body weight were significantly greater in HFC diet-fed hamsters than in normal diet-fed hamsters. Triglyceride, low-density lipoprotein cholesterol, and glucose levels in blood were significantly increased in HFC diet-fed hamsters, and blood pressure also tended to be high, suggesting that the HFC diet-fed hamsters developed metabolic syndrome...
January 1, 2018: Experimental Animals
https://www.readbyqxmd.com/read/29298724/brainstem-tau-pathology-in-alzheimer-s-disease-is-characterized-by-increase-of-three-repeat-tau-and-independent-of-amyloid%C3%A2-%C3%AE
#3
Miho Uematsu, Ayako Nakamura, Momoko Ebashi, Katsuiku Hirokawa, Ryosuke Takahashi, Toshiki Uchihara
INTRODUCTION: Alzheimer-type neuropil threads (NTs) and neurofibrillary tangles (NFTs) are comprised of either 4 repeat (4R)-tau, 3 repeat (3R)-tau, or a mixture of both. In the hippocampus, the number of NFTs, and the proportion of 3R tau progressively increases. If this preferential accumulation of 3R tau also occurs in the brainstem, it may be fundamentally related to progression of Alzheimer pathology. METHODS: Midbrain and pontine sections of brainstems from 23 cases (Braak-NFT stages I/II: 8, III/IV: 8, and V/VI: 7) were double immunofluorolabeled for 4R and 3R tau...
January 3, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29279450/ten-year-surveillance-of-measles-virus-from-2007-2016-in-osaka-city-japan
#4
Atsushi Kaida, Nobuhiro Iritani, Daiki Kanbayashi, Seiji P Yamamoto, Yuki Hirai, Noritaka Hakui, Ryoko Fujimori, Hiromi Mori, Hidetetsu Hirokawa, Jun Ogasawara, Hideyuki Kubo
  Measles is a highly contagious infection caused by the measles virus (MV). In this study, long-term surveillance was performed in order to survey MV prevalence. A total of 417 patients diagnosed with or suspected of having measles were tested for MV between January 2007 and December 2016 in Osaka City, Japan. Reverse transcription-polymerase chain reaction (RT-PCR)-based testing of clinical specimens showed that 54 patients (12.9%) were MV-positive. An MV epidemic occurred in 2007, in which all detected MV strains were of genotype D5, an epidemic strain in Japan at that time...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29259759/correction-to-structure-based-design-of-ask1-inhibitors-as-potential-agents-for-heart-failure
#5
Marion Lanier, Jason Pickens, Simone V Bigi, Erica L Bradshaw-Pierce, Alison Chambers, Zacharia S Cheruvallath, Derek Cole, Douglas R Dougan, Jacques Ermolieff, Tony Gibson, Petro Halkowycz, Aki Hirokawa, Anthony Ivetac, Christopher McBride, Joanne Miura, Evan Nunez, Mark Sabat, John Tyhonas, Haixia Wang, Xiaolun Wang, Steve Swann
[This corrects the article DOI: 10.1021/acsmedchemlett.6b00481.].
December 14, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29237001/beneficial-effect-of-body-weight-control-on-left-ventricular-diastolic-function-in-the-general-population-an-analysis-of-longitudinal-data-from-a-health-check-up-clinic
#6
Seitetz C Lee, Masao Daimon, Marco R Di Tullio, Shunichi Homma, Takahiro Hasegawa, Sy Han Chiou, Tomoko Nakao, Megumi Hirokawa, Yoshiko Mizuno, Yutaka Yatomi, Tsutomu Yamazaki, Issei Komuro
Aims: Left ventricular (LV) diastolic dysfunction may lead to heart failure. A high body mass index (BMI) is associated with worse LV diastolic function. However, knowledge of the longitudinal relation between changes in BMI and LV diastolic function is limited. Methods and results: We retrospectively identified 165 asymptomatic individuals (aged 60 ± 10 years, 55% male) with preserved LV ejection fraction, who underwent repeated health check-ups (median interval: 365 days) at our hospital between 2009 and 2012...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29225076/crystal-structures-of-human-orexin-2-receptor-bound-to-the-subtype-selective-antagonist-empa
#7
Ryoji Suno, Kanako Terakado Kimura, Takanori Nakane, Keitaro Yamashita, Junmei Wang, Takaaki Fujiwara, Yasuaki Yamanaka, Dohyun Im, Shoichiro Horita, Hirokazu Tsujimoto, Maki S Tawaramoto, Takatsugu Hirokawa, Eriko Nango, Kensuke Tono, Takashi Kameshima, Takaki Hatsui, Yasumasa Joti, Makina Yabashi, Keiko Shimamoto, Masaki Yamamoto, Daniel M Rosenbaum, So Iwata, Tatsuro Shimamura, Takuya Kobayashi
Orexin peptides in the brain regulate physiological functions such as the sleep-wake cycle, and are thus drug targets for the treatment of insomnia. Using serial femtosecond crystallography and multi-crystal data collection with a synchrotron light source, we determined structures of human orexin 2 receptor in complex with the subtype-selective antagonist EMPA (N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulfonyl)-amino]-N-pyridin-3-ylmethyl-acetamide) at 2.30-Å and 1.96-Å resolution. In comparison with the non-subtype-selective antagonist suvorexant, EMPA contacted fewer residues through hydrogen bonds at the orthosteric site, explaining the faster dissociation rate...
November 27, 2017: Structure
https://www.readbyqxmd.com/read/29216149/on-chip-wavelength-locking-for-photonic-switches
#8
Akhilesh S P Khope, Takako Hirokawa, Andrew M Netherton, Mitra Saeidi, Yujie Xia, Nicolas Volet, Clint Schow, Roger Helkey, Luke Theogarajan, Adel A M Saleh, John E Bowers, Rod C Alferness
We present an on-chip wavelength reference with a partial drop ring resonator and germanium photodetector. This approach can be used in ring-resonator-based wavelength-selective switches where absolute wavelength alignment is required. We use the temperature dependence of heater resistance as a temperature sensor. Additionally, we discuss locking speed, statistical variation of heater resistances, and tuning speed of the switches.
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29210473/binding-pathway-analysis-of-influenza-virus-m2-channel-blockers-by-metadynamics-simulation
#9
Yuri Sakai, Atsushi Kawaguchi, Kyosuke Nagata, Takatsugu Hirokawa
M2 protein of influenza A virus is a proton channel spanning the viral envelope. This proton channel activity is required for uncoating of viral particles and equilibrating the pH across the trans-Golgi apparatus to prevent a conformational change of hemagglutinin. Amantadine is an anti-influenza A virus drug which inhibits M2 proton channel activity by binding to the channel pore, however, the majority of currently circulating influenza A viruses are amantadine-resistant. The most prevalent resistant mutation is a substitution from Ser31 to Asn31 in M2...
December 6, 2017: Microbiology and Immunology
https://www.readbyqxmd.com/read/29204883/multiple-analyses-of-protein-dynamics-in-solution
#10
REVIEW
Tadayuki Ogawa, Nobutaka Hirokawa
The need for accurate description of protein behavior in solution has gained importance in various fields, including biophysics, biochemistry, structural biology, drug discovery, and antibody drugs. To achieve the desired accuracy, multiple precise analyses should be performed on the target molecule, compared, and effectively combined. This review focuses on the combination of multiple analyses in solution: size-exclusion chromatography (SEC), multi-angle light scattering (MALS), small-angle X-ray scattering (SAXS), analytical ultracentrifugation (AUC), and their complementary methods, such as atomic force microscopy (AFM) and mass spectrometry (MS)...
December 4, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/29199205/re-evaluation-of-mib-1-immunostaining-for-diagnosing-hyalinizing-trabecular-tumour-of-the-thyroid-semi-automated-techniques-with-manual-antigen-retrieval-are-more-accurate-than-fully-automated-techniques
#11
Nami Takada, Mitsuyoshi Hirokawa, Chiho Ohbayashi, Takeshi Nishikawa, Tomoo Itoh, Naoko Imagawa, Tetsunari Oyama, Tadashi Handa, Tadashi Hasegawa, Shintaro Sugita, Akiko Murata, Akira Miyauchi
Hyalinizing trabecular tumour (HTT) immunohistochemically shows cell membranous immunoreactivity for MIB-1. This aberrant immunoreactivity is an important factor for the diagnosis of HTT. However, fully automated stainers frequently fail to confirm the immunoreactivity. The aim of this study is to investigate the cause of false negative cell membranous immunoreactivity for MIB-1 in HTT using fully automated stainers, to determine potential reasons for the problem, and to establish methods confirming cell membranous immunoreactivity for MIB-1 in HTT...
December 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29196081/prognostic-impact-of-donor-source-on-allogeneic-hematopoietic-stem-cell-transplantation-outcomes-in-adults-with-chronic-myelomonocytic-leukemia-a-nationwide-retrospective-analysis-in-japan
#12
Hidehiro Itonaga, Kazunari Aoki, Jun Aoki, Takayuki Ishikawa, Ken Ishiyama, Naoyuki Uchida, Toru Sakura, Kazuteru Ohashi, Mineo Kurokawa, Yukiyasu Ozawa, Ken-Ichi Matsuoka, Yukinori Nakamura, Fumihiko Kimura, Koji Iwato, Yuichiro Nawa, Makoto Hirokawa, Koji Kato, Tatsuo Ichinohe, Yoshiko Atsuta, Yasushi Miyazaki
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapeutic option for chronic myelomonocytic leukemia (CMML). We retrospectively compared the post-transplant outcomes of 159 CMML patients who received allo-HSCT using 4 types of donor sources: human leukocyte antigen (HLA)-matched related donor grafts, unrelated bone marrow, unrelated cord blood, and HLA-mismatched related donor grafts. The median patient age at allo-HSCT was 54 years (range, 16 -75 years). In multivariate analyses, the use of HLA-matched related donor grafts correlated with better OS than unrelated bone marrow (hazard ratio [HR], 2...
November 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29178875/metabolic-engineering-of-synechococcus-elongatus-pcc-7942-for-improvement-of-1-3-propanediol-and-glycerol-production-based-on-in-silico-simulation-of-metabolic-flux-distribution
#13
Yasutaka Hirokawa, Shingo Matsuo, Hiroyuki Hamada, Fumio Matsuda, Taizo Hanai
BACKGROUND: Production directly from carbon dioxide by engineered cyanobacteria is one of the promising technologies for sustainable future. Previously, we have successfully achieved 1,3-propanediol (1,3-PDO) production using Synechococcus elongatus PCC 7942 with a synthetic metabolic pathway. The strain into which the synthetic metabolic pathway was introduced produced 3.48 mM (0.265 g/L) 1,3-PDO and 14.3 mM (1.32 g/L) glycerol during 20 days of incubation. In this study, the productivities of 1,3-PDO were improved by gene disruption selected by screening with in silico simulation...
November 25, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29164484/association-between-cortisol-to-dhea-s-ratio-and-sickness-absence-in-japanese-male-workers
#14
Kumi Hirokawa, Yasuhito Fujii, Toshiyo Taniguchi, Jiro Takaki, Akizumi Tsutsumi
PURPOSE: This study aimed to investigate the association between serum levels of cortisol and dehydroepiandrosterone sulfate (DHEA-s) and sickness absence over 2 years in Japanese male workers. METHOD: A baseline survey including questions about health behavior, along with blood sampling for cortisol and DHEA-s, was conducted in 2009. In total, 429 men (mean ± SD age, 52.9 ± 8.6 years) from whom blood samples were collected at baseline were followed until December 31, 2011...
November 21, 2017: International Journal of Behavioral Medicine
https://www.readbyqxmd.com/read/29123863/successful-non-operative-management-of-traumatic-extrahepatic-portal-venous-injury-without-intraperitoneal-hemorrhage-a-case-report
#15
Kunio Hamanaka, Yuusuke Hirokawa, Tsuyoshi Itoh, Mitsuhiro Fujino, Kenichi Kano, Satoru Beppu, Nozomu Sasahashi, Kei Nishiyama
Case: A 52-year-old woman was admitted to our hospital with hypotension after falling from the fifth floor of an apartment building. Contrast-enhanced computed tomography showed liver injury with extravasation of contrast material from the hepatic artery, and extrahepatic portal venous injury with extravasation and pseudoaneurysm. Intra-abdominal hemorrhage was not observed, and bleeding was confined to the retroperitoneal space. Hepatic arteriography showed extravasation, while portal venography showed pseudoaneurysm but no extravasation...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29099658/laparoscopic-hepatic-resection-using-extracorporeal-pringle-maneuver
#16
Yoshihiro Inoue, Yusuke Suzuki, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
BACKGROUND: Laparoscopic hepatic resection (LHR) has been developed as a novel minimally invasive surgery. However, despite improvements in equipment and procedures, intraoperative hemorrhage remains an issue that requires great precaution. To reduce the amount of intraoperative blood loss, we perform the Pringle maneuver, aimed at occluding the inflow of blood into the liver during LHR. This article describes our experience performing LHR using the Pringle maneuver, including postoperative results, and discusses the safety and effectiveness of the Pringle maneuver...
November 3, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29094782/thyroid-fna-cytology-in-asian-practice-active-surveillance-for-indeterminate-thyroid-nodules-reduces-overtreatment-of-thyroid-carcinomas
#17
REVIEW
K Kakudo, M Higuchi, M Hirokawa, S Satoh, C K Jung, A Bychkov
Although Asian thyroid practices have implemented the American Thyroid Association guidelines, significant deviations in actual risk of malignancy (ROM) have been reported. With review of the literature from Asia, the authors examine the underlining reasons for actual ROMs reported in Asia being so different from western practice based on the author's perspective. Although the most popular diagnostic system for thyroid cytology used in Asian countries is the Bethesda system, the Japan Thyroid Association published clinical guidelines, including a national reporting system for thyroid cytology, to adapt conservative clinical management (active surveillance and strict triage patients for surgery) for low-risk thyroid carcinomas...
November 2, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29093307/warthin-like-papillary-thyroid-carcinoma-with-immunoglobulin-g4-positive-plasma-cells-possibly-related-to-hashimoto-s-thyroiditis
#18
Mitsuyoshi Hirokawa, Eijun Nishihara, Nami Takada, Miyoko Higuchi, Masumi Kotakemori, Toshitetsu Hayashi, Akira Miyauchi
Hashimoto's thyroiditis with heavy lymphoplasmacytic infiltration is a common comorbidity of immunoglobulin G4 (IgG4)-related thyroiditis and Warthin-like papillary thyroid carcinoma (WL-PTC). We hypothesized that WL-PTC may have a strong association with IgG4-related thyroiditis. To validate this hypothesis, we clinically and immunohistochemically studied 17 WL-PTC cases. Fourteen patients (82.4%) had anti-thyroglobulin antibody and were confirmed to have Hashimoto's thyroiditis through microscopic analysis...
November 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29081471/errata-preoperative-diagnostic-algorithm-of-primary-thyroid-lymphoma-using-ultrasound-aspiration-cytology-and-flow-cytometry-endocrine-journal-vol-64-9-859-865-2017
#19
Mitsuyoshi Hirokawa, Takumi Kudo, Hisashi Ota, Ayana Suzuki, Kaoru Kobayashi, Akira Miyauchi
Abstract, Table 4, and the paragraph of "Diagnostic accuracy (Table 4)" on page 863 contain some typographical errors. There are some typographical errors on page 864.
2017: Endocrine Journal
https://www.readbyqxmd.com/read/29041620/forward-bias-operation-of-silicon-photonic-mach-zehnder-modulators-for-rf-applications
#20
Rui Lin Chao, Jin Wei Shi, Aditya Jain, Takako Hirokawa, Akhilesh S P Khope, Clint Schow, J E Bowers, Roger Helkey, James F Buckwalter
In this paper, we demonstrate that forward bias (+0.9V) of a high-speed silicon (Si) optical Mach-Zehnder modulator (MZM) increases the radio-frequency (RF) link gain by 30 dB when compared to reverse bias operation (-8V). RF applications require tunable, narrowband electro-optic conversion with high gain to mitigate noise of the optical receiver and realize high RF spur-free dynamic range. Compared to reverse bias, the forward bias gain rolls off more rapidly but offers higher RF link gain improvement of more than 13...
September 18, 2017: Optics Express
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