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https://www.readbyqxmd.com/read/29123863/successful-non-operative-management-of-traumatic-extrahepatic-portal-venous-injury-without-intraperitoneal-hemorrhage-a-case-report
#1
Kunio Hamanaka, Yuusuke Hirokawa, Tsuyoshi Itoh, Mitsuhiro Fujino, Kenichi Kano, Satoru Beppu, Nozomu Sasahashi, Kei Nishiyama
Case: A 52-year-old woman was admitted to our hospital with hypotension after falling from the fifth floor of an apartment building. Contrast-enhanced computed tomography showed liver injury with extravasation of contrast material from the hepatic artery, and extrahepatic portal venous injury with extravasation and pseudoaneurysm. Intra-abdominal hemorrhage was not observed, and bleeding was confined to the retroperitoneal space. Hepatic arteriography showed extravasation, while portal venography showed pseudoaneurysm but no extravasation...
April 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29099658/laparoscopic-hepatic-resection-using-extracorporeal-pringle-maneuver
#2
Yoshihiro Inoue, Yusuke Suzuki, Kensuke Fujii, Nao Kawaguchi, Masatsugu Ishii, Shinsuke Masubuchi, Masashi Yamamoto, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
BACKGROUND: Laparoscopic hepatic resection (LHR) has been developed as a novel minimally invasive surgery. However, despite improvements in equipment and procedures, intraoperative hemorrhage remains an issue that requires great precaution. To reduce the amount of intraoperative blood loss, we perform the Pringle maneuver, aimed at occluding the inflow of blood into the liver during LHR. This article describes our experience performing LHR using the Pringle maneuver, including postoperative results, and discusses the safety and effectiveness of the Pringle maneuver...
November 3, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29094782/thyroid-fna-cytology-in-asian-practice-active-surveillance-for-indeterminate-thyroid-nodules-reduces-overtreatment-of-thyroid-carcinomas
#3
REVIEW
K Kakudo, M Higuchi, M Hirokawa, S Satoh, C K Jung, A Bychkov
Although Asian thyroid practices have implemented the American Thyroid Association guidelines, significant deviations in actual risk of malignancy (ROM) have been reported. With review of the literature from Asia, the authors examine the underlining reasons for actual ROMs reported in Asia being so different from western practice based on the author's perspective. Although the most popular diagnostic system for thyroid cytology used in Asian countries is the Bethesda system, the Japan Thyroid Association published clinical guidelines, including a national reporting system for thyroid cytology, to adapt conservative clinical management (active surveillance and strict triage patients for surgery) for low-risk thyroid carcinomas...
November 2, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29093307/warthin-like-papillary-thyroid-carcinoma-with-immunoglobulin-g4-positive-plasma-cells-possibly-related-to-hashimoto-s-thyroiditis
#4
Mitsuyoshi Hirokawa, Eijun Nishihara, Nami Takada, Miyoko Higuchi, Masumi Kotakemori, Toshitetsu Hayashi, Akira Miyauchi
Hashimoto's thyroiditis with heavy lymphoplasmacytic infiltration is a common comorbidity of immunoglobulin G4 (IgG4)-related thyroiditis and Warthin-like papillary thyroid carcinoma (WL-PTC). We hypothesized that WL-PTC may have a strong association with IgG4-related thyroiditis. To validate this hypothesis, we clinically and immunohistochemically studied 17 WL-PTC cases. Fourteen patients (82.4%) had anti-thyroglobulin antibody and were confirmed to have Hashimoto's thyroiditis through microscopic analysis...
November 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29081471/errata-preoperative-diagnostic-algorithm-of-primary-thyroid-lymphoma-using-ultrasound-aspiration-cytology-and-flow-cytometry-endocrine-journal-vol-64-9-859-865-2017
#5
Mitsuyoshi Hirokawa, Takumi Kudo, Hisashi Ota, Ayana Suzuki, Kaoru Kobayashi, Akira Miyauchi
Abstract, Table 4, and the paragraph of "Diagnostic accuracy (Table 4)" on page 863 contain some typographical errors. There are some typographical errors on page 864.
2017: Endocrine Journal
https://www.readbyqxmd.com/read/29041620/forward-bias-operation-of-silicon-photonic-mach-zehnder-modulators-for-rf-applications
#6
Rui Lin Chao, Jin Wei Shi, Aditya Jain, Takako Hirokawa, Akhilesh S P Khope, Clint Schow, J E Bowers, Roger Helkey, James F Buckwalter
In this paper, we demonstrate that forward bias (+0.9V) of a high-speed silicon (Si) optical Mach-Zehnder modulator (MZM) increases the radio-frequency (RF) link gain by 30 dB when compared to reverse bias operation (-8V). RF applications require tunable, narrowband electro-optic conversion with high gain to mitigate noise of the optical receiver and realize high RF spur-free dynamic range. Compared to reverse bias, the forward bias gain rolls off more rapidly but offers higher RF link gain improvement of more than 13...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29025875/a-small-molecule-compound-inhibits-a-collagen-specific-molecular-chaperone-and-could-represent-a-potential-remedy-for-fibrosis
#7
Shinya Ito, Koji Ogawa, Koh Takeuchi, Motoki Takagi, Masahito Yoshida, Takatsugu Hirokawa, Shoshiro Hirayama, Kazuo Shin-Ya, Ichio Shimada, Takayuki Doi, Naoki Goshima, Tohru Natsume, Kazuhiro Nagata
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promising strategy for the management of fibrotic disorders, such as liver and lung fibrosis. Hsp47 is an endoplasmic reticulum (ER)-resident collagen-specific molecular chaperone essential for correct folding of procollagen in the ER. Genetic deletion of Hsp47 or inhibition of its interaction with procollagen interferes with procollagen triple helix production, which vastly reduces procollagen secretion from fibroblasts...
October 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28935984/regulation-of-axonal-regeneration-by-the-level-of-function-of-the-endogenous-nogo-receptor-antagonist-lotus
#8
Tomoko Hirokawa, Yixiao Zou, Yuji Kurihara, Zhaoxin Jiang, Yusuke Sakakibara, Hiromu Ito, Kengo Funakoshi, Nobutaka Kawahara, Yoshio Goshima, Stephen M Strittmatter, Kohtaro Takei
Axonal regeneration in the adult mammalian central nervous system is limited in part by the non-permissive environment, including axonal growth inhibitors such as the Nogo-A protein. How the functions of these inhibitors can be blocked remains unclear. Here, we examined the role of LOTUS, an endogenous Nogo receptor antagonist, in promoting functional recovery and neural repair after spinal cord injury (SCI), as well as axonal regeneration after optic nerve crush. Wild-type untreated mice show incomplete but substantial intrinsic motor recovery after SCI...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28931921/an-iterative-compound-screening-contest-method-for-identifying-target-protein-inhibitors-using-the-tyrosine-protein-kinase-yes
#9
Shuntaro Chiba, Takashi Ishida, Kazuyoshi Ikeda, Masahiro Mochizuki, Reiji Teramoto, Y-H Taguchi, Mitsuo Iwadate, Hideaki Umeyama, Chandrasekaran Ramakrishnan, A Mary Thangakani, D Velmurugan, M Michael Gromiha, Tatsuya Okuno, Koya Kato, Shintaro Minami, George Chikenji, Shogo D Suzuki, Keisuke Yanagisawa, Woong-Hee Shin, Daisuke Kihara, Kazuki Z Yamamoto, Yoshitaka Moriwaki, Nobuaki Yasuo, Ryunosuke Yoshino, Sergey Zozulya, Petro Borysko, Roman Stavniichuk, Teruki Honma, Takatsugu Hirokawa, Yutaka Akiyama, Masakazu Sekijima
We propose a new iterative screening contest method to identify target protein inhibitors. After conducting a compound screening contest in 2014, we report results acquired from a contest held in 2015 in this study. Our aims were to identify target enzyme inhibitors and to benchmark a variety of computer-aided drug discovery methods under identical experimental conditions. In both contests, we employed the tyrosine-protein kinase Yes as an example target protein. Participating groups virtually screened possible inhibitors from a library containing 2...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929234/comparison-of-regeneration-of-remnant-liver-after-hemihepatectomy-with-or-without-the-middle-hepatic-vein
#10
Yoshihiro Inoue, Yusuke Suzuki, Masato Ota, Kensuke Fujii, Nao Kawaguchi, Tetsunosuke Shimizu, Mitsuhiro Asakuma, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
BACKGROUND: There is no consensus about remnant liver regeneration associated with middle hepatic vein (MHV) resecting. METHODS: Seventy-five patients who underwent hemihepatectomy were retrospectively analysed with respect to remnant liver regeneration. The liver remnant volume (LRV) and each sectional volume were postoperatively measured with multidetector computed tomography at day 7 and months 1, 2, 5, and 12 after the operation. RESULTS: In right hemihepatectomy cases, the regeneration rate of LRV in the MHV preservation group was significantly higher than that of the MHV resection group at months 5 and 12...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28904306/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-a-single-institutional-experience-in-japan
#11
Mitsuyoshi Hirokawa, Miyoko Higuchi, Ayana Suzuki, Toshitetsu Hayashi, Seiji Kuma, Akira Miyauchi
Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) was reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). To date, no studies on NIFTP have been reported in Japan. This study aimed to evaluate the clinical, cytological, and pathological findings of 54 cases of NIFTP from a single center in Japan, and compare them with those in the western countries. There were no significant differences in age, sex, or tumor size between patients with NIFTP and those with invasive encapsulated follicular variant -PTC...
September 12, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28903043/mechanism-of-catalytic-microtubule-depolymerization-via-kif2-tubulin-transitional-conformation
#12
Tadayuki Ogawa, Shinya Saijo, Nobutaka Shimizu, Xuguang Jiang, Nobutaka Hirokawa
Microtubules (MTs) are dynamic structures that are fundamental for cell morphogenesis and motility. MT-associated motors work efficiently to perform their functions. Unlike other motile kinesins, KIF2 catalytically depolymerizes MTs from the peeled protofilament end during ATP hydrolysis. However, the detailed mechanism by which KIF2 drives processive MT depolymerization remains unknown. To elucidate the catalytic mechanism, the transitional KIF2-tubulin complex during MT depolymerization was analyzed through multiple methods, including atomic force microscopy, size-exclusion chromatography, multi-angle light scattering, small-angle X-ray scattering, analytical ultracentrifugation, and mass spectrometry...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28886336/temperature-sensitive-substrate-and-product-binding-underlie-temperature-compensated-phosphorylation-in-the-clock
#13
Yuta Shinohara, Yohei M Koyama, Maki Ukai-Tadenuma, Takatsugu Hirokawa, Masaki Kikuchi, Rikuhiro G Yamada, Hideki Ukai, Hiroshi Fujishima, Takashi Umehara, Kazuki Tainaka, Hiroki R Ueda
Temperature compensation is a striking feature of the circadian clock. Here we investigate biochemical mechanisms underlying temperature-compensated, CKIδ-dependent multi-site phosphorylation in mammals. We identify two mechanisms for temperature-insensitive phosphorylation at higher temperature: lower substrate affinity to CKIδ-ATP complex and higher product affinity to CKIδ-ADP complex. Inhibitor screening of ADP-dependent phosphatase activity of CKIδ identified aurintricarboxylic acid (ATA) as a temperature-sensitive kinase activator...
September 7, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28883261/fine-needle-aspiration-cytology-for-medullary-thyroid-carcinoma-a-single-institutional-experience-in-japan
#14
Ayana Suzuki, Mitsuyoshi Hirokawa, Nami Takada, Miyoko Higuchi, Aki Ito, Naoki Yamao, Toshitetsu Hayashi, Seiji Kuma, Akira Miyauchi
Many cytological studies on medullary thyroid carcinoma (MTC) have been reported; however, such studies in large series of patients with MTC have not been performed. We investigated MTC at a single institution in Japan using fine-needle aspiration cytology (FNAC), and aimed to establish a preoperative diagnostic algorithm for MTC. FNAC was performed in 119 of 149 patients with nodules (79.9%) who ultimately underwent surgical resection. Moreover, hereditary MTC was diagnosed preoperatively in 22 nodules that did not undergo FNAC (39...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28878401/structural-basis-for-crmp2-induced-axonal-microtubule-formation
#15
Shinsuke Niwa, Fumio Nakamura, Yuri Tomabechi, Mari Aoki, Hideki Shigematsu, Takashi Matsumoto, Atsushi Yamagata, Shuya Fukai, Nobutaka Hirokawa, Yoshio Goshima, Mikako Shirouzu, Ryo Nitta
Microtubule associated protein Collapsin response mediator protein 2 (CRMP2) regulates neuronal polarity in developing neurons through interactions with tubulins or microtubules. However, how CRMP2 promotes axonal formation by affecting microtubule behavior remains unknown. This study aimed to obtain the structural basis for CRMP2-tubulin/microtubule interaction in the course of axonogenesis. The X-ray structural studies indicated that the main interface to the soluble tubulin-dimer is the last helix H19 of CRMP2 that is distinct from the known C-terminal tail-mediated interaction with assembled microtubules...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28855636/a-novel-chiral-stationary-phase-lc-ms-ms-method-to-evaluate-oxidation-mechanisms-of-edible-oils
#16
Junya Ito, Naoki Shimizu, Eri Kobayashi, Yasuhiko Hanzawa, Yurika Otoki, Shunji Kato, Takafumi Hirokawa, Shigefumi Kuwahara, Teruo Miyazawa, Kiyotaka Nakagawa
The elucidation of lipid oxidation mechanisms of food is vital. In certain lipids, characteristic lipid hydroperoxide isomers are formed by different oxidation mechanisms (i.e., photo-oxidation or auto-oxidation). For example, linoleic acid is photo-oxidized to 13-9Z, 11E-hydroperoxyoctadecadienoic acid (HPODE), 12-9Z,13E-HPODE, 10-8E,12Z-HPODE and 9-10E,12Z-HPODE, whereas 13-9Z, 11E-HPODE, 13-9E,11E-HPODE, 9-10E,12Z-HPODE and 9-10E,12E-HPODE are formed by auto-oxidation. Therefore, we considered that oxidation mechanisms could be evaluated by analyzing these characteristic positional and cis/trans lipid hydroperoxide isomers...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821980/serum-calcitonin-reference-values-for-calcium-stimulation-tests-by-electrochemiluminescence-immunoassay-in-japanese-men-with-non-medullary-thyroid-carcinoma
#17
Minoru Kihara, Akira Miyauchi, Takumi Kudo, Mitsuyoshi Hirokawa, Akihiro Miya
PURPOSE: Calcitonin is the most sensitive tumor marker of medullary thyroid carcinoma (MTC) and a calcium stimulation test is used to improve this sensitivity. In Japan, the electrochemiluminescence immunoassay (ECLIA) is currently the only test performed to measure serum calcitonin. There is a gender difference in the reference value of serum calcitonin; however, a reference upper limit for use with ECLIA has been reported only for women, but not for men. METHODS: We conducted the calcium stimulation test using ECLIA in 21 men with non-medullary thyroid carcinoma (non-MTC), before and after total thyroidectomy...
August 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28810260/cytoplasmic-lipid-accumulation-characteristic-of-the-cribriform-variant-of-papillary-thyroid-carcinoma
#18
Nami Takada, Mitsuyoshi Hirokawa, Aki Ito, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Tsutomu Daa, Akira Miyauchi
OBJECTIVE: The purpose of this study was to clarify the diagnostic significance of cytoplasmic lipid accumulation (CLIA) in the cribriform variant of papillary thyroid carcinoma (CV-PTC). METHODS: We performed a histological, immunohistochemical, and cytological examination of 35 CV-PTC cases at the Kuma Hospital. CLIA was defined as bubble-like multivacuolation in cytoplasm with distinct cell border. We also examined 100 conventional PTC (con-PTC) cases as controls...
August 16, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28794344/papillary-thyroid-carcinoma-with-desmoid-type-fibromatosis-a-clinical-pathological-and-immunohistochemical-study-of-14-cases
#19
Nami Takada, Mitsuyoshi Hirokawa, Masahiro Ito, Aki Ito, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Toshitetsu Hayashi, Masao Kishikawa, Shuichi Horikawa, Akira Miyauchi
Papillary thyroid carcinoma (PTC) with desmoid-type fibromatosis (DTF) is characterized by genetic alterations of the fibroblasts. However, PTC-DTF is extremely rare, and the reports on such cases have been sporadic. Immunohistochemical staining using the antibody for beta-catenin is useful in diagnosing the variant. This report aims to describe the clinical, pathological, and immunohistochemical findings in 14 cases of PTC-DTF and to clarify the diagnostic significance of the variant. The patients included 9 women and 5 men, with a mean age of 49...
August 10, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28794343/comparative-histopathological-analysis-of-sporadic-pediatric-papillary-thyroid-carcinoma-from-japan-and-ukraine
#20
Tetiana I Bogdanova, Vladimir A Saenko, Mitsuyoshi Hirokawa, Masahiro Ito, Liudmyla Yu Zurnadzhy, Toshitetsu Hayashi, Tatiana I Rogounovitch, Akira Miyauchi, Mykola D Tronko, Shunichi Yamashita
This study set out to compare structural and invasive characteristics of sporadic papillary thyroid carcinoma (PTC) in age-matched groups of children and adolescents of Japan and Ukraine to provide detailed histopathological analysis of tumors from different geographical areas with different iodine intake. A total of 348 (160 Japanese and 188 Ukrainian) PTCs from patients without radiation history were analyzed initially as a combined pediatric group and then subdivided into childhood (aged ≤14 years) and adolescent (aged from 15 to ≤18 years) age series...
August 10, 2017: Endocrine Journal
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