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https://www.readbyqxmd.com/read/28817982/current-challenges-in-optimizing-systemic-therapy-for-patients-with-pancreatic-cancer-expert-perspectives-from-the-australian-gastrointestinal-trials-group-with-invited-international-faculty
#1
Eva Segelov, Florian Lordick, David Goldstein, Lorraine A Chantrill, Daniel Croagh, Ben Lawrence, Dirk Arnold, Ian Chau, Radka Obermannova, Timothy Jay Price
Despite recent progress, the outlook for most patients with pancreatic cancer remains poor. There is variation in how patients are managed globally due to differing interpretations of the evidence, partly because studies in this disease are challenging to undertake. This article collates the evidence upon which current best practice is based and offers an expert opinion from an international faculty on how latest developments should influence current treatment paradigms. Areas covered: Optimal chemotherapy for first and subsequent lines of therapy; optimal management of locally advanced, non-metastatic cancer including the role of neoadjuvant chemo(radio)therapy, current evidence for adjuvant chemotherapy, major advances in pancreatic cancer genomics and challenges in supportive care particularly relevant to patients with pancreatic cancer...
August 18, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28692723/safety-of-converting-from-tetrabenazine-to-deutetrabenazine-for-the-treatment-of-chorea
#2
Samuel Frank, David Stamler, Elise Kayson, Daniel O Claassen, Amy Colcher, Charles Davis, Andrew Duker, Shirley Eberly, Lawrence Elmer, Erin Furr-Stimming, Mark Gudesblatt, Christine Hunter, Joseph Jankovic, Sandra K Kostyk, Rajeev Kumar, Clement Loy, William Mallonee, David Oakes, Burton L Scott, Victor Sung, Jody Goldstein, Christina Vaughan, Claudia M Testa
Importance: Tetrabenazine is efficacious for chorea control; however, tolerability concerns exist. Deutetrabenazine, a novel molecule that reduces chorea, was well tolerated in a double-blind, placebo-controlled study. Objectives: To evaluate the safety and explore the efficacy of conversion from tetrabenazine to deutetrabenazine in patients with chorea associated with Huntington disease (HD). Design, Setting, and Participants: In this ongoing, open-label, single-arm study that started on December 21, 2013, 37 patients at 13 Huntington Study Group sites in the United States and Australia who were taking stable doses of tetrabenazine that provided a therapeutic benefit were switched overnight to deutetrabenazine therapy...
August 1, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28663189/erratum-national-institutes-of-health-sponsored-clinical-islet-transplantation-consortium-phase-3-trial-manufacture-of-a-complex-cellular-product-at-eight-processing-facilities-diabetes-2016-65-3418-3428
#3
Camillo Ricordi, Julia S Goldstein, A N Balamurugan, Gregory L Szot, Tatsuya Kin, Chengyang Liu, Christine W Czarniecki, Barbara Barbaro, Nancy D Bridges, Jose Cano, William R Clarke, Thomas L Eggerman, Lawrence G Hunsicker, Dixon B Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A Turgeon, Daniel Brandhorst, Andrew S Friberg, Ji Lei, Ling-Jia Wang, Joshua J Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J Hering, Andrew M Posselt, Peter G Stock, A M James Shapiro
No abstract text is available yet for this article.
June 29, 2017: Diabetes
https://www.readbyqxmd.com/read/28457113/stereotactic-ablative-body-radiation-for-stage-i-lung-cancer-in-israel-a-retrospective-single-center-report
#4
Sarit Appel, Yaacov R Lawrence, Jeffery Goldstein, Raphael M Pfeffer, Ilana Weiss, Tatiana Rabin, Shira Felder, Maoz Ben-Ayun, Lev Tzvang, Dror Alezra, David Simansky, Alon Ben-Nun, Jair Bar, Zvi Symon
BACKGROUND: Stereotactic ablative radiation therapy (SABR) is the application of a very high radiation dose to a small treatment volume. It is the new standard of care in medically inoperable early-stage lung cancer. OBJECTIVES: To report the outcomes of SABR in stage I lung cancer at Sheba Medical Center since its introduction in 2009. METHODS: We conducted a retrospective chart review of patients with stage I lung cancer treated during the period 2009-2015...
January 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28457109/salvage-radiation-therapy-for-biochemical-failure-following-radical-prostatectomy
#5
Benjamin Spieler, Jeffrey Goldstein, Yaacov R Lawrence, Akram Saad, Raanan Berger, Jacob Ramon, Zohar Dotan, Menachem Laufer, Ilana Weiss, Lev Tzvang, Philip Poortmans, Zvi Symon
BACKGROUND: Radiotherapy to the prostate bed is used to eradicate residual microscopic disease following radical prostatectomy for prostate cancer. Recommendations are based on historical series. OBJECTIVES: To determine outcomes and toxicity of contemporary salvage radiation therapy (SRT) to the prostate bed. METHODS: We reviewed a prospective ethics committee-approved database of 229 patients referred for SRT. Median pre-radiation prostate-specific antigen (PSA) was 0...
January 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28410643/high-throughput-and-cost-effective-characterization-of-induced-pluripotent-stem-cells
#6
Matteo D'Antonio, Grace Woodruff, Jason L Nathanson, Agnieszka D'Antonio-Chronowska, Angelo Arias, Hiroko Matsui, Roy Williams, Cheryl Herrera, Sol M Reyna, Gene W Yeo, Lawrence S B Goldstein, Athanasia D Panopoulos, Kelly A Frazer
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes. To date, studies have been published that use small panels of iPSC-derived cell lines to study monogenic diseases. However, to study complex diseases, where the genetic variation underlying the disorder is unknown, a sizable number of patient-specific iPSC lines and controls need to be generated...
April 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28410642/ipscore-a-resource-of-222-ipsc-lines-enabling-functional-characterization-of-genetic-variation-across-a-variety-of-cell-types
#7
Athanasia D Panopoulos, Matteo D'Antonio, Paola Benaglio, Roy Williams, Sherin I Hashem, Bernhard M Schuldt, Christopher DeBoever, Angelo D Arias, Melvin Garcia, Bradley C Nelson, Olivier Harismendy, David A Jakubosky, Margaret K R Donovan, William W Greenwald, KathyJean Farnam, Megan Cook, Victor Borja, Carl A Miller, Jonathan D Grinstein, Frauke Drees, Jonathan Okubo, Kenneth E Diffenderfer, Yuriko Hishida, Veronica Modesto, Carl T Dargitz, Rachel Feiring, Chang Zhao, Aitor Aguirre, Thomas J McGarry, Hiroko Matsui, He Li, Joaquin Reyna, Fangwen Rao, Daniel T O'Connor, Gene W Yeo, Sylvia M Evans, Neil C Chi, Kristen Jepsen, Naoki Nariai, Franz-Josef Müller, Lawrence S B Goldstein, Juan Carlos Izpisua Belmonte, Eric Adler, Jeanne F Loring, W Travis Berggren, Agnieszka D'Antonio-Chronowska, Erin N Smith, Kelly A Frazer
Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a collection of systematically derived and characterized iPSC lines from 222 ethnically diverse individuals that allows for both familial and association-based genetic studies. iPSCORE lines are pluripotent with high genomic integrity (no or low numbers of somatic copy-number variants) as determined using high-throughput RNA-sequencing and genotyping arrays, respectively...
April 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28399641/optimization-of-degradation-profile-for-new-scaffold-in-cartilage-repair
#8
Sarav S Shah, Haixiang Liang, Sandeep Pandit, Zalak Parikh, John A Schwartz, Todd Goldstein, Lawrence P Lavelle, Arindam Datta, Daniel A Grande
Objective To establish whether a novel biomaterial scaffold with tunable degradation profile will aid in cartilage repair of chondral defects versus microfracture alone in vitro and in a rat model in vivo. Design In vitro-Short- and long-term degradation scaffolds were seeded with culture expanded articular chondrocytes or bone marrow mesenchymal stem cells. Cell growth and differentiation were evaluated with cell morphological studies and gene expression studies. In vivo-A microfracture rat model was used in this study to evaluate the repair of cartilage and subchondral bone with the contralateral knee serving as the empty control...
April 1, 2017: Cartilage
https://www.readbyqxmd.com/read/28392217/high-throughput-and-cost-effective-characterization-of-induced-pluripotent-stem-cells
#9
Matteo D'Antonio, Grace Woodruff, Jason L Nathanson, Agnieszka D'Antonio-Chronowska, Angelo Arias, Hiroko Matsui, Roy Williams, Cheryl Herrera, Sol M Reyna, Gene W Yeo, Lawrence S B Goldstein, Athanasia D Panopoulos, Kelly A Frazer
Reprogramming somatic cells to induced pluripotent stem cells (iPSCs) offers the possibility of studying the molecular mechanisms underlying human diseases in cell types difficult to extract from living patients, such as neurons and cardiomyocytes. To date, studies have been published that use small panels of iPSC-derived cell lines to study monogenic diseases. However, to study complex diseases, where the genetic variation underlying the disorder is unknown, a sizable number of patient-specific iPSC lines and controls need to be generated...
April 4, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28392216/ipscore-a-resource-of-222-ipsc-lines-enabling-functional-characterization-of-genetic-variation-across-a-variety-of-cell-types
#10
Athanasia D Panopoulos, Matteo D'Antonio, Paola Benaglio, Roy Williams, Sherin I Hashem, Bernhard M Schuldt, Christopher DeBoever, Angelo D Arias, Melvin Garcia, Bradley C Nelson, Olivier Harismendy, David A Jakubosky, Margaret K R Donovan, William W Greenwald, KathyJean Farnam, Megan Cook, Victor Borja, Carl A Miller, Jonathan D Grinstein, Frauke Drees, Jonathan Okubo, Kenneth E Diffenderfer, Yuriko Hishida, Veronica Modesto, Carl T Dargitz, Rachel Feiring, Chang Zhao, Aitor Aguirre, Thomas J McGarry, Hiroko Matsui, He Li, Joaquin Reyna, Fangwen Rao, Daniel T O'Connor, Gene W Yeo, Sylvia M Evans, Neil C Chi, Kristen Jepsen, Naoki Nariai, Franz-Josef Müller, Lawrence S B Goldstein, Juan Carlos Izpisua Belmonte, Eric Adler, Jeanne F Loring, W Travis Berggren, Agnieszka D'Antonio-Chronowska, Erin N Smith, Kelly A Frazer
Large-scale collections of induced pluripotent stem cells (iPSCs) could serve as powerful model systems for examining how genetic variation affects biology and disease. Here we describe the iPSCORE resource: a collection of systematically derived and characterized iPSC lines from 222 ethnically diverse individuals that allows for both familial and association-based genetic studies. iPSCORE lines are pluripotent with high genomic integrity (no or low numbers of somatic copy-number variants) as determined using high-throughput RNA-sequencing and genotyping arrays, respectively...
April 3, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28346025/guidance-on-radiation-dose-limits-for-the-lens-of-the-eye-overview-of-the-recommendations-in-ncrp-commentary-no-26
#11
Lawrence T Dauer, Elizabeth A Ainsbury, Joseph Dynlacht, David Hoel, Barbara E K Klein, Donald Mayer, Christina R Prescott, Raymond H Thornton, Eliseo Vano, Gayle E Woloschak, Cynthia M Flannery, Lee E Goldstein, Nobuyuki Hamada, Phung K Tran, Michael P Grissom, Eleanor A Blakely
PURPOSE: This review summarizes the conclusions and recommendations of the new National Council on Radiation Protection and Measurements (NCRP) Commentary No. 26 guidance on radiation dose limits for the lens of the eye. The NCRP addressed radiation protection principles in respect to the lens of the eye, discussed the current understanding of eye biology and lens effects, reviewed and evaluated epidemiology, and assessed exposed populations with the potential for significant radiation exposures to the lens while suggesting monitoring and protection practices...
April 3, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28152137/human-machine-collaboration-in-cancer-and-beyond-the-centaur-care-model
#12
Ian M Goldstein, Julie Lawrence, Adam S Miner
No abstract text is available yet for this article.
February 2, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28132722/multiple-pregnancies-with-complete-mole-and-coexisting-normal-fetus-in-north-and-south-america-a-retrospective-multicenter-cohort-and-literature-review
#13
REVIEW
Lawrence H Lin, Izildinha Maestá, Antonio Braga, Sue Y Sun, Koji Fushida, Rossana P V Francisco, Kevin M Elias, Neil Horowitz, Donald P Goldstein, Ross S Berkowitz
OBJECTIVE: To determine the clinical characteristics of multiple gestation with complete mole and coexisting fetus (CHMCF) in North and South America. METHODS: Retrospective non-concurrent cohorts compromised of CHMCF from New England Trophoblastic Disease Center (NETDC) (1966-2015) and four Brazilian Trophoblastic Disease Centers (BTDC) (1990-2015). RESULTS: From a total of 12,455 cases of gestational trophoblastic disease seen, 72 CHMCF were identified...
April 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28061904/classifying-high-risk-versus-very-high-risk-prostate-cancer-is-it-relevant-to-outcomes-of-conformal-radiotherapy-and-androgen-deprivation
#14
Akram Saad, Jeffrey Goldstein, Yaacov R Lawrence, Benjamin Spieler, Raya Leibowitz-Amit, Raanan Berger, Tima Davidson, Damien Urban, Lev Tsang, Dror Alezra, Ilana Weiss, Zvi Symon
OBJECTIVE: To evaluate outcomes in prostate cancer patients classified as high-risk (HR) or very high-risk (VHR) who were treated with conformal radiation therapy (CRT) and androgen deprivation therapy (ADT). METHODS: Between 11/2001 and 3/2012, 203 patients with HR disease received CRT to the prostate (78-82 Gy) and pelvic lymph nodes (46-50 Gy) with ADT (6 m-2 years). Median follow-up was 50 months (12 m-142 m). Biochemical failure was defined according to Phoenix definition...
January 6, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/27732852/defective-transcytosis-of-app-and-lipoproteins-in-human-ipsc-derived-neurons-with-familial-alzheimer-s-disease-mutations
#15
Grace Woodruff, Sol M Reyna, Mariah Dunlap, Rik Van Der Kant, Julia A Callender, Jessica E Young, Elizabeth A Roberts, Lawrence S B Goldstein
We investigated early phenotypes caused by familial Alzheimer's disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci revealed that fAD mutant neurons had previously unreported defects in the recycling state of endocytosis and soma-to-axon transcytosis of APP and lipoproteins. The endocytosis reduction could be rescued through treatment with a β-secretase inhibitor. Our data suggest that accumulation of β-CTFs of APP, but not Aβ, slow vesicle formation from an endocytic recycling compartment marked by the transcytotic GTPase Rab11...
October 11, 2016: Cell Reports
https://www.readbyqxmd.com/read/27675553/the-role-of-prostate-specific-membrane-antigen-psma-positron-emission-tomography-computed-tomography-in-the-management-of-patients-with-prostate-cancer-implications-for-selection-of-patients-for-radiation-therapy
#16
U Amit, J D Goldstein, T Davidson, M Hahiashvili, E Goshen, Y Oksman, R Berger, A Saad, I Sadetsky, B Chikman, Y R Lawrence, S Ben-Haim, Z Symon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675285/effects-of-continuous-positive-airway-pressure-cpap-used-for-respiratory-motion-management-in-patients-receiving-chest-radiation-to-the-heart-an-analysis-of-size-position-and-motion
#17
N Weizman, K Baidun, A Goldstein, U Amit, Y Lawrence, S Appel, M Benayun, S Dubinski, I Orion, D Alezra, H Gnessin, Z Symon, J D Goldstein
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674975/the-impact-of-a-detailed-checklist-on-physician-peer-review-in-radiation-oncology-a-prospective-study
#18
Y Lawrence, T Katzman, M Ben-Aiun, M Ben David, S Galper, S Appel, A Ziv, O Luxenburg, J D Goldstein, Z Symon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674764/does-pathologic-response-to-neoadjuvant-chemoradiation-to-60-gy-predict-survival-in-locally-advanced-non-small-cell-lung-cancer
#19
S Appel, J D Goldstein, Z Symon, Y Lawrence, J Bar, T Rabin, M Ben Ayun, T Davidson, A Ben Nun
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27655099/a-retrospective-feasibility-study-of-salvage-pelvic-nodal-radiation-in-6-patients-with-biochemical-failure-following-prostate-fossa-radiation-an-alternative-to-androgen-deprivation-therapy-adt
#20
Zvi Symon, Guy Ben-Bezalel, Ben Spieler, Lev Tsvang, Dror Alezra, Raanan Berger, Zohar Dotan, Yaacov R Lawrence, Jeffrey Goldstein
PURPOSE: To evaluate salvage pelvic nodal radiation as an alternative to androgen deprivation therapy (ADT) in patients with biochemical failure and lymph node recurrence following salvage prostate fossa radiation. METHODS: Six patients with biochemical failure and lymph node recurrence following prostate fossa radiation were treated with salvage pelvic nodal radiation therapy. A gross target volume was contoured using Choline PET/CT, CT, or MRI imaging. The clinical target volume included pelvic nodes...
October 2016: American Journal of Clinical Oncology
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