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https://www.readbyqxmd.com/read/27732852/defective-transcytosis-of-app-and-lipoproteins-in-human-ipsc-derived-neurons-with-familial-alzheimer-s-disease-mutations
#1
Grace Woodruff, Sol M Reyna, Mariah Dunlap, Rik Van Der Kant, Julia A Callender, Jessica E Young, Elizabeth A Roberts, Lawrence S B Goldstein
We investigated early phenotypes caused by familial Alzheimer's disease (fAD) mutations in isogenic human iPSC-derived neurons. Analysis of neurons carrying fAD PS1 or APP mutations introduced using genome editing technology at the endogenous loci revealed that fAD mutant neurons had previously unreported defects in the recycling state of endocytosis and soma-to-axon transcytosis of APP and lipoproteins. The endocytosis reduction could be rescued through treatment with a β-secretase inhibitor. Our data suggest that accumulation of β-CTFs of APP, but not Aβ, slow vesicle formation from an endocytic recycling compartment marked by the transcytotic GTPase Rab11...
October 11, 2016: Cell Reports
https://www.readbyqxmd.com/read/27675553/the-role-of-prostate-specific-membrane-antigen-psma-positron-emission-tomography-computed-tomography-in-the-management-of-patients-with-prostate-cancer-implications-for-selection-of-patients-for-radiation-therapy
#2
U Amit, J D Goldstein, T Davidson, M Hahiashvili, E Goshen, Y Oksman, R Berger, A Saad, I Sadetsky, B Chikman, Y R Lawrence, S Ben-Haim, Z Symon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675285/effects-of-continuous-positive-airway-pressure-cpap-used-for-respiratory-motion-management-in-patients-receiving-chest-radiation-to-the-heart-an-analysis-of-size-position-and-motion
#3
N Weizman, K Baidun, A Goldstein, U Amit, Y Lawrence, S Appel, M Benayun, S Dubinski, I Orion, D Alezra, H Gnessin, Z Symon, J D Goldstein
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674975/the-impact-of-a-detailed-checklist-on-physician-peer-review-in-radiation-oncology-a-prospective-study
#4
Y Lawrence, T Katzman, M Ben-Aiun, M Ben David, S Galper, S Appel, A Ziv, O Luxenburg, J D Goldstein, Z Symon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674764/does-pathologic-response-to-neoadjuvant-chemoradiation-to-60-gy-predict-survival-in-locally-advanced-non-small-cell-lung-cancer
#5
S Appel, J D Goldstein, Z Symon, Y Lawrence, J Bar, T Rabin, M Ben Ayun, T Davidson, A Ben Nun
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27655099/a-retrospective-feasibility-study-of-salvage-pelvic-nodal-radiation-in-6-patients-with-biochemical-failure-following-prostate-fossa-radiation-an-alternative-to-androgen-deprivation-therapy-adt
#6
Zvi Symon, Guy Ben-Bezalel, Ben Spieler, Lev Tsvang, Dror Alezra, Raanan Berger, Zohar Dotan, Yaacov R Lawrence, Jeffrey Goldstein
PURPOSE: To evaluate salvage pelvic nodal radiation as an alternative to androgen deprivation therapy (ADT) in patients with biochemical failure and lymph node recurrence following salvage prostate fossa radiation. METHODS: Six patients with biochemical failure and lymph node recurrence following prostate fossa radiation were treated with salvage pelvic nodal radiation therapy. A gross target volume was contoured using Choline PET/CT, CT, or MRI imaging. The clinical target volume included pelvic nodes...
October 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27532834/case-records-of-the-massachusetts-general-hospital-case-25-2016-a-33-year-old-man-with-rectal-pain-and-bleeding
#7
Jessica A Zeidman, Paul C Shellito, Benjamin T Davis, Lawrence R Zukerberg
Presentation of Case. Dr. Robert H. Goldstein (Medicine): A 33-year-old man was seen in the surgery clinic of this hospital because of painful bowel movements and rectal bleeding. The patient had been well until approximately 4 months before this presentation, when pain with defecation developed...
August 18, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27512572/transperineal-implantation-of-gold-fiducial-markers-gold%C3%A2-seeds-for-prostate-image-guided-radiation-therapy-a%C3%A2-feasible-technique-associated-with-a-low-risk-of-complications
#8
Akram Saad, Jeffrey Goldstein, Yaacov Richard Lawrence, Ilana Weiss, Rasha Saad, Benjamin Spieler, Zvi Symon
INTRODUCTION: The purpose is to describe the method, safety and efficacy of transperineal gold seed placement for image-guided radiation therapy. METHODS: An ethics committee approved database was used to review records of consecutive patients from October 2008 through December 2013, who underwent transperineal implantation of three gold markers into the prostate using staged local anaesthesia and transrectal ultrasound. Seeds were counted on radiographs from CT simulation, first treatment and last treatment...
December 2015: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27465220/nih-sponsored-clinical-islet-transplantation-consortium-phase-3-trial-manufacture-of-a-complex-cellular-product-at-eight-processing-facilities
#9
Camillo Ricordi, Julia S Goldstein, A N Balamurugan, Gregory L Szot, Tatsuya Kin, Chengyang Liu, Christine W Czarniecki, Barbara Barbaro, Nancy D Bridges, Jose Cano, William R Clarke, Thomas L Eggerman, Lawrence G Hunsicker, Dixon B Kaufman, Aisha Khan, David-Erick Lafontant, Elina Linetsky, Xunrong Luo, James F Markmann, Ali Naji, Olle Korsgren, Jose Oberholzer, Nicole A Turgeon, Daniel Brandhorst, Andrew S Friberg, Ji Lei, Ling-Jia Wang, Joshua J Wilhelm, Jamie Willits, Xiaomin Zhang, Bernhard J Hering, Andrew M Posselt, A M James Shapiro
Eight manufacturing facilities participating in the NIH-sponsored Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a harmonized process for manufacture of the allogeneic Purified Human Pancreatic Islet (PHPI) product evaluated in a Phase 3 trial in subjects with Type 1 Diabetes. Manufacturing was controlled by a common Master Production Batch Record (MPBR), standard operating procedures including acceptance criteria for deceased donor organ pancreata and critical raw materials, PHPI product specifications, certificate of analysis (CoA) and test methods...
July 27, 2016: Diabetes
https://www.readbyqxmd.com/read/27459331/randomized-phase-2-trial-of-a-coordinated-breast-cancer-follow-up-care-program
#10
Kathryn J Ruddy, Hao Guo, Emily L Baker, Matthew J Goldstein, Erin E Mullaney, Lawrence N Shulman, Ann H Partridge
BACKGROUND: Previous research has demonstrated that cancer survivors often fail to receive recommended care and also undergo unnecessary care; this reduces care quality and increases costs. METHODS: This phase 2 trial randomized 100 stage 0 to IIIa breast cancer patients who had primary care providers within a large Massachusetts-based hospital network (with accessible online records) to either coordinated follow-up care (CC), which entailed a tailored survivorship care plan (SCP) and patient navigator calls every 3 months, or standard care (SC), which did not include an SCP or patient navigation, for 1 year after the completion of their last chemotherapy, surgery, or radiation treatment...
July 26, 2016: Cancer
https://www.readbyqxmd.com/read/27343020/adult-onset-hypogonadism
#11
REVIEW
Mohit Khera, Gregory A Broderick, Culley C Carson, Adrian S Dobs, Martha M Faraday, Irwin Goldstein, Lawrence S Hakim, Wayne J G Hellstrom, Ravi Kacker, Tobias S Köhler, Jesse N Mills, Martin Miner, Hossein Sadeghi-Nejad, Allen D Seftel, Ira D Sharlip, Stephen J Winters, Arthur L Burnett
In August 2015, an expert colloquium commissioned by the Sexual Medicine Society of North America (SMSNA) convened in Washington, DC, to discuss the common clinical scenario of men who present with low testosterone (T) and associated signs and symptoms accompanied by low or normal gonadotropin levels. This syndrome is not classical primary (testicular failure) or secondary (pituitary or hypothalamic failure) hypogonadism because it may have elements of both presentations. The panel designated this syndrome adult-onset hypogonadism (AOH) because it occurs commonly in middle-age and older men...
July 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27218464/prediction-and-quantification-of-splice-events-from-rna-seq-data
#12
Leonard D Goldstein, Yi Cao, Gregoire Pau, Michael Lawrence, Thomas D Wu, Somasekar Seshagiri, Robert Gentleman
Analysis of splice variants from short read RNA-seq data remains a challenging problem. Here we present a novel method for the genome-guided prediction and quantification of splice events from RNA-seq data, which enables the analysis of unannotated and complex splice events. Splice junctions and exons are predicted from reads mapped to a reference genome and are assembled into a genome-wide splice graph. Splice events are identified recursively from the graph and are quantified locally based on reads extending across the start or end of each splice variant...
2016: PloS One
https://www.readbyqxmd.com/read/27208344/phase-3-trial-of-transplantation-of-human-islets-in-type-1-diabetes-complicated-by-severe-hypoglycemia
#13
Bernhard J Hering, William R Clarke, Nancy D Bridges, Thomas L Eggerman, Rodolfo Alejandro, Melena D Bellin, Kathryn Chaloner, Christine W Czarniecki, Julia S Goldstein, Lawrence G Hunsicker, Dixon B Kaufman, Olle Korsgren, Christian P Larsen, Xunrong Luo, James F Markmann, Ali Naji, Jose Oberholzer, Andrew M Posselt, Michael R Rickels, Camillo Ricordi, Mark A Robien, Peter A Senior, A M James Shapiro, Peter G Stock, Nicole A Turgeon
OBJECTIVE: Impaired awareness of hypoglycemia (IAH) and severe hypoglycemic events (SHEs) cause substantial morbidity and mortality in patients with type 1 diabetes (T1D). Current therapies are effective in preventing SHEs in 50-80% of patients with IAH and SHEs, leaving a substantial number of patients at risk. We evaluated the effectiveness and safety of a standardized human pancreatic islet product in subjects in whom IAH and SHEs persisted despite medical treatment. RESEARCH DESIGN AND METHODS: This multicenter, single-arm, phase 3 study of the investigational product purified human pancreatic islets (PHPI) was conducted at eight centers in North America...
July 2016: Diabetes Care
https://www.readbyqxmd.com/read/26943901/development-and-feasibility-testing-of-a-critical-care-eeg-monitoring-database-for-standardized-clinical-reporting-and-multicenter-collaborative-research
#14
Jong Woo Lee, Suzette LaRoche, Hyunmi Choi, Andres A Rodriguez Ruiz, Evan Fertig, Jeffrey M Politsky, Susan T Herman, Tobias Loddenkemper, Arnold J Sansevere, Pearce J Korb, Nicholas S Abend, Joshua L Goldstein, Saurabh R Sinha, Keith E Dombrowski, Eva K Ritzl, Michael B Westover, Jay R Gavvala, Elizabeth E Gerard, Sarah E Schmitt, Jerzy P Szaflarski, Kan Ding, Kevin F Haas, Richard Buchsbaum, Lawrence J Hirsch, Courtney J Wusthoff, Jennifer L Hopp, Cecil D Hahn
PURPOSE: The rapid expansion of the use of continuous critical care electroencephalogram (cEEG) monitoring and resulting multicenter research studies through the Critical Care EEG Monitoring Research Consortium has created the need for a collaborative data sharing mechanism and repository. The authors describe the development of a research database incorporating the American Clinical Neurophysiology Society standardized terminology for critical care EEG monitoring. The database includes flexible report generation tools that allow for daily clinical use...
April 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/26768488/complex-regulation-of-adar-mediated-rna-editing-across-tissues
#15
Melanie A Huntley, Melanie Lou, Leonard D Goldstein, Michael Lawrence, Gerrit J P Dijkgraaf, Joshua S Kaminker, Robert Gentleman
BACKGROUND: RNA-editing is a tightly regulated, and essential cellular process for a properly functioning brain. Dysfunction of A-to-I RNA editing can have catastrophic effects, particularly in the central nervous system. Thus, understanding how the process of RNA-editing is regulated has important implications for human health. However, at present, very little is known about the regulation of editing across tissues, and individuals. RESULTS: Here we present an analysis of RNA-editing patterns from 9 different tissues harvested from a single mouse...
2016: BMC Genomics
https://www.readbyqxmd.com/read/26717175/status-of-ncrp-scientific-committee-1-23-commentary-on-guidance-on-radiation-dose-limits-for-the-lens-of-the-eye
#16
Lawrence T Dauer, Elizabeth A Ainsbury, Joseph Dynlacht, David Hoel, Barbara E K Klein, Don Mayer, Christina R Prescott, Raymond H Thornton, Eliseo Vano, Gayle E Woloschak, Cynthia M Flannery, Lee E Goldstein, Nobuyuki Hamada, Phung K Tran, Michael P Grissom, Eleanor A Blakely
Previous National Council on Radiation Protection and Measurements (NCRP) publications have addressed the issues of risk and dose limitation in radiation protection and included guidance on specific organs and the lens of the eye. NCRP decided to prepare an updated commentary intended to enhance the previous recommendations provided in earlier reports. The NCRP Scientific Committee 1-23 (SC 1-23) is charged with preparing a commentary that will evaluate recent studies on the radiation dose response for the development of cataracts and also consider the type and severity of the cataracts as well as the dose rate; provide guidance on whether existing dose limits to the lens of the eye should be changed in the United States; and suggest research needs regarding radiation effects on and dose limits to the lens of the eye...
February 2016: Health Physics
https://www.readbyqxmd.com/read/26555112/herpesviruses-including-novel-gammaherpesviruses-are-widespread-among-phocid-seal-species-in-canada
#17
Christian Bellehumeur, Ole Nielsen, Lena Measures, Lois Harwood, Tracey Goldstein, Brian Boyle, Carl A Gagnon
Little is known about herpesviruses in Canadian pinnipeds. We measured prevalence of antibodies to herpesviruses in the sera from Canadian phocid seals by an indirect enzyme-linked immunosorbent assay. Wild harbor seals (Phoca vitulina) and captive harbor seals were positive for antibodies to Phocid herpesvirus 1 (PhoHV-1) at prevalences of 91% and 100%, respectively. Sera from wild hooded seals (Cystophora cristata), harp seals (Pagophilus groenlandica), and grey seals (Halichoerus grypus) were positive for antibodies to PhoHV-1 antigenically related herpesvirus antigens at 73%, 79%, and 96%, respectively...
January 2016: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/26464424/analysis-of-heritability-and-shared-heritability-based-on-genome-wide-association-studies-for-thirteen-cancer-types
#18
Joshua N Sampson, William A Wheeler, Meredith Yeager, Orestis Panagiotou, Zhaoming Wang, Sonja I Berndt, Qing Lan, Christian C Abnet, Laufey T Amundadottir, Jonine D Figueroa, Maria Teresa Landi, Lisa Mirabello, Sharon A Savage, Philip R Taylor, Immaculata De Vivo, Katherine A McGlynn, Mark P Purdue, Preetha Rajaraman, Hans-Olov Adami, Anders Ahlbom, Demetrius Albanes, Maria Fernanda Amary, She-Juan An, Ulrika Andersson, Gerald Andriole, Irene L Andrulis, Emanuele Angelucci, Stephen M Ansell, Cecilia Arici, Bruce K Armstrong, Alan A Arslan, Melissa A Austin, Dalsu Baris, Donald A Barkauskas, Bryan A Bassig, Nikolaus Becker, Yolanda Benavente, Simone Benhamou, Christine Berg, David Van Den Berg, Leslie Bernstein, Kimberly A Bertrand, Brenda M Birmann, Amanda Black, Heiner Boeing, Paolo Boffetta, Marie-Christine Boutron-Ruault, Paige M Bracci, Louise Brinton, Angela R Brooks-Wilson, H Bas Bueno-de-Mesquita, Laurie Burdett, Julie Buring, Mary Ann Butler, Qiuyin Cai, Geraldine Cancel-Tassin, Federico Canzian, Alfredo Carrato, Tania Carreon, Angela Carta, John K C Chan, Ellen T Chang, Gee-Chen Chang, I-Shou Chang, Jiang Chang, Jenny Chang-Claude, Chien-Jen Chen, Chih-Yi Chen, Chu Chen, Chung-Hsing Chen, Constance Chen, Hongyan Chen, Kexin Chen, Kuan-Yu Chen, Kun-Chieh Chen, Ying Chen, Ying-Hsiang Chen, Yi-Song Chen, Yuh-Min Chen, Li-Hsin Chien, María-Dolores Chirlaque, Jin Eun Choi, Yi Young Choi, Wong-Ho Chow, Charles C Chung, Jacqueline Clavel, Françoise Clavel-Chapelon, Pierluigi Cocco, Joanne S Colt, Eva Comperat, Lucia Conde, Joseph M Connors, David Conti, Victoria K Cortessis, Michelle Cotterchio, Wendy Cozen, Simon Crouch, Marta Crous-Bou, Olivier Cussenot, Faith G Davis, Ti Ding, W Ryan Diver, Miren Dorronsoro, Laure Dossus, Eric J Duell, Maria Grazia Ennas, Ralph L Erickson, Maria Feychting, Adrienne M Flanagan, Lenka Foretova, Joseph F Fraumeni, Neal D Freedman, Laura E Beane Freeman, Charles Fuchs, Manuela Gago-Dominguez, Steven Gallinger, Yu-Tang Gao, Susan M Gapstur, Montserrat Garcia-Closas, Reina García-Closas, Randy D Gascoyne, Julie Gastier-Foster, Mia M Gaudet, J Michael Gaziano, Carol Giffen, Graham G Giles, Edward Giovannucci, Bengt Glimelius, Michael Goggins, Nalan Gokgoz, Alisa M Goldstein, Richard Gorlick, Myron Gross, Robert Grubb, Jian Gu, Peng Guan, Marc Gunter, Huan Guo, Thomas M Habermann, Christopher A Haiman, Dina Halai, Goran Hallmans, Manal Hassan, Claudia Hattinger, Qincheng He, Xingzhou He, Kathy Helzlsouer, Brian Henderson, Roger Henriksson, Henrik Hjalgrim, Judith Hoffman-Bolton, Chancellor Hohensee, Theodore R Holford, Elizabeth A Holly, Yun-Chul Hong, Robert N Hoover, Pamela L Horn-Ross, G M Monawar Hosain, H Dean Hosgood, Chin-Fu Hsiao, Nan Hu, Wei Hu, Zhibin Hu, Ming-Shyan Huang, Jose-Maria Huerta, Jen-Yu Hung, Amy Hutchinson, Peter D Inskip, Rebecca D Jackson, Eric J Jacobs, Mazda Jenab, Hyo-Sung Jeon, Bu-Tian Ji, Guangfu Jin, Li Jin, Christoffer Johansen, Alison Johnson, Yoo Jin Jung, Rudolph Kaaks, Aruna Kamineni, Eleanor Kane, Chang Hyun Kang, Margaret R Karagas, Rachel S Kelly, Kay-Tee Khaw, Christopher Kim, Hee Nam Kim, Jin Hee Kim, Jun Suk Kim, Yeul Hong Kim, Young Tae Kim, Young-Chul Kim, Cari M Kitahara, Alison P Klein, Robert J Klein, Manolis Kogevinas, Takashi Kohno, Laurence N Kolonel, Charles Kooperberg, Anne Kricker, Vittorio Krogh, Hideo Kunitoh, Robert C Kurtz, Sun-Seog Kweon, Andrea LaCroix, Charles Lawrence, Fernando Lecanda, Victor Ho Fun Lee, Donghui Li, Haixin Li, Jihua Li, Yao-Jen Li, Yuqing Li, Linda M Liao, Mark Liebow, Tracy Lightfoot, Wei-Yen Lim, Chien-Chung Lin, Dongxin Lin, Sara Lindstrom, Martha S Linet, Brian K Link, Chenwei Liu, Jianjun Liu, Li Liu, Börje Ljungberg, Josep Lloreta, Simonetta Di Lollo, Daru Lu, Eiluv Lund, Nuria Malats, Satu Mannisto, Loic Le Marchand, Neyssa Marina, Giovanna Masala, Giuseppe Mastrangelo, Keitaro Matsuo, Marc Maynadie, James McKay, Roberta McKean-Cowdin, Mads Melbye, Beatrice S Melin, Dominique S Michaud, Tetsuya Mitsudomi, Alain Monnereau, Rebecca Montalvan, Lee E Moore, Lotte Maxild Mortensen, Alexandra Nieters, Kari E North, Anne J Novak, Ann L Oberg, Kenneth Offit, In-Jae Oh, Sara H Olson, Domenico Palli, William Pao, In Kyu Park, Jae Yong Park, Kyong Hwa Park, Ana Patiño-Garcia, Sofia Pavanello, Petra H M Peeters, Reury-Perng Perng, Ulrike Peters, Gloria M Petersen, Piero Picci, Malcolm C Pike, Stefano Porru, Jennifer Prescott, Ludmila Prokunina-Olsson, Biyun Qian, You-Lin Qiao, Marco Rais, Elio Riboli, Jacques Riby, Harvey A Risch, Cosmeri Rizzato, Rebecca Rodabough, Eve Roman, Morgan Roupret, Avima M Ruder, Silvia de Sanjose, Ghislaine Scelo, Alan Schned, Fredrick Schumacher, Kendra Schwartz, Molly Schwenn, Katia Scotlandi, Adeline Seow, Consol Serra, Massimo Serra, Howard D Sesso, Veronica Wendy Setiawan, Gianluca Severi, Richard K Severson, Tait D Shanafelt, Hongbing Shen, Wei Shen, Min-Ho Shin, Kouya Shiraishi, Xiao-Ou Shu, Afshan Siddiq, Luis Sierrasesúmaga, Alan Dart Loon Sihoe, Christine F Skibola, Alex Smith, Martyn T Smith, Melissa C Southey, John J Spinelli, Anthony Staines, Meir Stampfer, Marianna C Stern, Victoria L Stevens, Rachael S Stolzenberg-Solomon, Jian Su, Wu-Chou Su, Malin Sund, Jae Sook Sung, Sook Whan Sung, Wen Tan, Wei Tang, Adonina Tardón, David Thomas, Carrie A Thompson, Lesley F Tinker, Roberto Tirabosco, Anne Tjønneland, Ruth C Travis, Dimitrios Trichopoulos, Fang-Yu Tsai, Ying-Huang Tsai, Margaret Tucker, Jenny Turner, Claire M Vajdic, Roel C H Vermeulen, Danylo J Villano, Paolo Vineis, Jarmo Virtamo, Kala Visvanathan, Jean Wactawski-Wende, Chaoyu Wang, Chih-Liang Wang, Jiu-Cun Wang, Junwen Wang, Fusheng Wei, Elisabete Weiderpass, George J Weiner, Stephanie Weinstein, Nicolas Wentzensen, Emily White, Thomas E Witzig, Brian M Wolpin, Maria Pik Wong, Chen Wu, Guoping Wu, Junjie Wu, Tangchun Wu, Wei Wu, Xifeng Wu, Yi-Long Wu, Jay S Wunder, Yong-Bing Xiang, Jun Xu, Ping Xu, Pan-Chyr Yang, Tsung-Ying Yang, Yuanqing Ye, Zhihua Yin, Jun Yokota, Ho-Il Yoon, Chong-Jen Yu, Herbert Yu, Kai Yu, Jian-Min Yuan, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Xu-Chao Zhang, Yawei Zhang, Xueying Zhao, Zhenhong Zhao, Hong Zheng, Tongzhang Zheng, Wei Zheng, Baosen Zhou, Meng Zhu, Mariagrazia Zucca, Simina M Boca, James R Cerhan, Giovanni M Ferri, Patricia Hartge, Chao Agnes Hsiung, Corrado Magnani, Lucia Miligi, Lindsay M Morton, Karin E Smedby, Lauren R Teras, Joseph Vijai, Sophia S Wang, Paul Brennan, Neil E Caporaso, David J Hunter, Peter Kraft, Nathaniel Rothman, Debra T Silverman, Susan L Slager, Stephen J Chanock, Nilanjan Chatterjee
BACKGROUND: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites. METHODS: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients...
December 2015: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/26330437/mechanical-ventilation-antioxidant-trial
#19
RANDOMIZED CONTROLLED TRIAL
Kimberly P Howe, John M Clochesy, Lawrence S Goldstein, Hugh Owen
BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation. OBJECTIVE: To test the clinical effectiveness of antioxidant supplementation in reducing the duration of mechanical ventilation...
September 2015: American Journal of Critical Care: An Official Publication, American Association of Critical-Care Nurses
https://www.readbyqxmd.com/read/26264628/continuous-positive-airway-pressure-for-motion-management-in-stereotactic-body-radiation-therapy-to-the-lung-a-controlled-pilot-study
#20
Jeffrey D Goldstein, Yaacov R Lawrence, Sarit Appel, Efrat Landau, Merav A Ben-David, Tatiana Rabin, Maoz Benayun, Sergey Dubinski, Noam Weizman, Dror Alezra, Hila Gnessin, Adam M Goldstein, Khader Baidun, Michael J Segel, Nir Peled, Zvi Symon
OBJECTIVE: To determine the effect of continuous positive airway pressure (CPAP) on tumor motion, lung volume, and dose to critical organs in patients receiving stereotactic body radiation therapy (SBRT) for lung tumors. METHODS AND MATERIALS: After institutional review board approval in December 2013, patients with primary or secondary lung tumors referred for SBRT underwent 4-dimensional computed tomographic simulation twice: with free breathing and with CPAP...
October 1, 2015: International Journal of Radiation Oncology, Biology, Physics
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