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https://www.readbyqxmd.com/read/29764242/morbidity-and-mortality-resulting-from-acute-inhalation-exposures-to-hydrogen-fluoride-and-carbonyl-fluoride-in-rats
#1
Adolph J Januszkiewicz, Matthew A Bazar, Lee C B Crouse, Michael A Chapman, Steven E Hodges, Steven J McCormick, Arthur J O'Neill
OBJECTIVE: Experiments were undertaken to compare morbidity and mortality from brief inhalation exposures to high levels of hydrogen fluoride (HF) and carbonyl fluoride (COF2 ). METHODS: Rats from both sexes were exposed for durations of 5 and 10 min to nominal concentrations of 10,000 to 57,000 ppm HF or 500 to 10,000 ppm COF2 . Respiration was monitored before, during, and after exposure. Animals were observed up to 6 days post-exposure. Terminal blood samples were collected for routine clinical chemistry and hematology...
May 15, 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29762108/midterm-follow-up-of-divergent-peg-glenoid-components-in-total-shoulder-arthroplasty
#2
Thomas W Wright, Tony L Bryant, Christopher G Stevens, Brett C Bentley, Kevin W Farmer
Glenoid component aseptic loosening is the most common source of total shoulder arthroplasty (TSA) revision. Divergent pegged glenoids may improve fixation. Thirty-four patients underwent divergent peg TSA. Data were reviewed for component loosening. Failure was defined as the need for revision after loosening. The last postoperative radiographs were graded on a Lazarus glenoid lucency scale. Mean follow-up was 5.6 years ± 2.44 (range, 2-10 years). Radiolucency around one or fewer pegs was noted in 14/20 patients...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29701261/a-critical-review-of-the-environmental-occurrence-and-potential-effects-in-aquatic-vertebrates-of-the-potent-androgen-receptor-agonist-17%C3%AE-trenbolone
#3
REVIEW
Gerald T Ankley, Katherine K Coady, Melanie Gross, Henrik Holbech, Steven L Levine, Gerd Maack, Mike Williams
Trenbolone acetate is widely-used in some parts of the world for its desirable anabolic effects on livestock. Several metabolites of the acetate, including 17β-trenbolone (βTRB), have been detected in at low ng/L concentrations in surface waters associated with animal feedlots. The βTRB isomer can affect androgen receptor (AR) signaling pathways in various vertebrate species at comparatively low concentrations/doses. This paper provides a comprehensive review and synthesis of the existing literature concerning exposure to and biological effects of βTRB, with an emphasis on potential risks to aquatic animals...
April 27, 2018: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29692172/infrastructure-shapes-differences-in-the-carbon-intensities-of-chinese-cities
#4
Bo Zheng, Qiang Zhang, Steven J Davis, Philippe Ciais, Chaopeng Hong, Meng Li, Fei Liu, Dan Tong, Haiyan Li, Kebin He
The carbon intensity of economic activity, or CO2 emissions per unit GDP, is a key indicator of the climate impacts of a given activity, business, or region. Although it is well-known that the carbon intensity of countries varies widely according to their level of economic development and dominant industries, few studies have assessed disparities in carbon intensity at the level of cities due to limited availability of data. Here, we present a detailed new inventory of emissions for 337 Chinese cities (every city in mainland China including 333 prefecture-level divisions and 4 province-level cities, Beijing, Tianjin, Shanghai, and Chongqing) in 2013, which we use to evaluate differences of carbon intensity between cities and the causes of those differences...
April 25, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29657083/the-course-of-awake-breathing-disturbances-across-the-lifespan-in-rett-syndrome
#5
Daniel C Tarquinio, Wei Hou, Jeffrey L Neul, Gamze Kilic Berkmen, Jana Drummond, Elizabeth Aronoff, Jennifer Harris, Jane B Lane, Walter E Kaufmann, Kathleen J Motil, Daniel G Glaze, Steven A Skinner, Alan K Percy
Rett syndrome (RTT), an X-linked dominant neurodevelopmental disorder caused by mutations in MECP2, is associated with a peculiar breathing disturbance exclusively during wakefulness that is distressing, and can even prompt emergency resuscitation. Through the RTT Natural History Study, we characterized cross sectional and longitudinal characteristics of awake breathing abnormalities in RTT and identified associated clinical features. Participants were recruited from 2006 to 2015, and cumulative lifetime prevalence of breathing dysfunction was determined using the Kaplan-Meier estimator...
April 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29657030/rewiring-of-glutamine-metabolism-is-a-bioenergetic-adaptation-of-human-cells-with-mitochondrial-dna-mutations
#6
Qiuying Chen, Kathryne Kirk, Yevgeniya I Shurubor, Dazhi Zhao, Andrea J Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L Calder, Valerio Carelli, Travis T Denton, M Flint Beal, Steven S Gross, Giovanni Manfredi, Marilena D'Aurelio
Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defects. Stimulating this flux with αKG supplementation enables the survival of diverse mtDNA mutant cells under otherwise lethal obligatory oxidative conditions. Strikingly, we demonstrate that when residual mitochondrial respiration in mtDNA mutant cells exceeds 45% of control levels, αKG oxidative flux prevails over reductive carboxylation...
April 9, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29625050/oncogenic-signaling-pathways-in-the-cancer-genome-atlas
#7
Francisco Sanchez-Vega, Marco Mina, Joshua Armenia, Walid K Chatila, Augustin Luna, Konnor C La, Sofia Dimitriadoy, David L Liu, Havish S Kantheti, Sadegh Saghafinia, Debyani Chakravarty, Foysal Daian, Qingsong Gao, Matthew H Bailey, Wen-Wei Liang, Steven M Foltz, Ilya Shmulevich, Li Ding, Zachary Heins, Angelica Ochoa, Benjamin Gross, Jianjiong Gao, Hongxin Zhang, Ritika Kundra, Cyriac Kandoth, Istemi Bahceci, Leonard Dervishi, Ugur Dogrusoz, Wanding Zhou, Hui Shen, Peter W Laird, Gregory P Way, Casey S Greene, Han Liang, Yonghong Xiao, Chen Wang, Antonio Iavarone, Alice H Berger, Trever G Bivona, Alexander J Lazar, Gary D Hammer, Thomas Giordano, Lawrence N Kwong, Grant McArthur, Chenfei Huang, Aaron D Tward, Mitchell J Frederick, Frank McCormick, Matthew Meyerson, Eliezer M Van Allen, Andrew D Cherniack, Giovanni Ciriello, Chris Sander, Nikolaus Schultz
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions and DNA methylation in 9,125 tumors profiled by The Cancer Genome Atlas (TCGA), we analyzed the mechanisms and patterns of somatic alterations in ten canonical pathways: cell cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 and β-catenin/Wnt...
April 5, 2018: Cell
https://www.readbyqxmd.com/read/29598944/three-dimensional-imaging-assessment-of-anatomic-invasion-and-volumetric-considerations-for-chemo-radiotherapy-based-laryngeal-preservation-in-t3-larynx-cancer
#8
Mona Kamal, Sweet Ping Ng, Salman A Eraj, Crosby D Rock, Brian Pham, Jay A Messer, Adam S Garden, William H Morrison, Jack Phan, Steven J Frank, Adel K El-Naggar, Jason M Johnson, Lawrence E Ginsberg, Renata Ferrarotto, Jan S Lewin, Katherine A Hutcheson, Carlos E Cardenas, Mark E Zafereo, Stephen Y Lai, Amy C Hessel, Randal S Weber, G Brandon Gunn, Clifton D Fuller, Abdallah S R Mohamed, David I Rosenthal
OBJECTIVES: To investigate the impact of 3-Diminsional (3D) tumor volume (TV) and extent of involvement of primary tumor on treatment outcomes in a large uniform cohort of T3 laryngeal carcinoma patients treated with nonsurgical laryngeal preservation strategies. MATERIALS AND METHODS: The pretreatment contrast-enhanced computed tomography images of 90 patients with T3 laryngeal carcinoma were reviewed. Primary gross tumor volume (GTVp) was delineated to calculate the 3D TV and define the extent of invasion...
April 2018: Oral Oncology
https://www.readbyqxmd.com/read/29573872/prevention-and-treatment-of-low-back-pain-evidence-challenges-and-promising-directions
#9
REVIEW
Nadine E Foster, Johannes R Anema, Dan Cherkin, Roger Chou, Steven P Cohen, Douglas P Gross, Paulo H Ferreira, Julie M Fritz, Bart W Koes, Wilco Peul, Judith A Turner, Chris G Maher
Many clinical practice guidelines recommend similar approaches for the assessment and management of low back pain. Recommendations include use of a biopsychosocial framework to guide management with initial non-pharmacological treatment, including education that supports self-management and resumption of normal activities and exercise, and psychological programmes for those with persistent symptoms. Guidelines recommend prudent use of medication, imaging, and surgery. The recommendations are based on trials almost exclusively from high-income countries, focused mainly on treatments rather than on prevention, with limited data for cost-effectiveness...
March 20, 2018: Lancet
https://www.readbyqxmd.com/read/29482852/sutureless-versus-conventional-pulmonary-vein-repair-a-magnetic-resonance-pilot-study
#10
Cornelia Tremblay, Shi-Joon Yoo, Luc Mertens, Mike Seed, Frederic Jacques, Cameron Slorach, Rachel Vanderlaan, Steven Greenway, Christopher Caldarone, John Coles, Lars Grosse-Wortmann
BACKGROUND: Two different surgical techniques are used to repair anomalous pulmonary venous connection or pulmonary vein (PV) stenosis: the classic repair (CR) and the sutureless repair (SR). The purpose of this study was to compare the prevalence of PV stenosis between the two surgical approaches. METHODS: Patients were prospectively recruited irrespective of symptoms or previous imaging findings. Cardiac magnetic resonance imaging and echocardiography were performed in a blinded fashion on the same day...
April 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29477167/human-pre-gastrulation-development
#11
Sissy E Wamaitha, Kathy K Niakan
Understanding the progression of early human embryonic development prior to implantation is of fundamental biological importance. Greater insights into early developmental events may lead to clinical improvements, not only via the establishment of novel stem cell models with increased potential or more physiological relevance, but also by uncovering some underlying causes of infertility, miscarriages, and developmental disorders. The majority of human embryos available for study are those donated to research once they are surplus to family building following in vitro fertilization, though in some countries it is also possible to create embryos using donated gametes...
2018: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/29466159/aspirin-or-rivaroxaban-for-vte-prophylaxis-after-hip-or-knee-arthroplasty
#12
RANDOMIZED CONTROLLED TRIAL
David R Anderson, Michael Dunbar, John Murnaghan, Susan R Kahn, Peter Gross, Michael Forsythe, Stephane Pelet, William Fisher, Etienne Belzile, Sean Dolan, Mark Crowther, Eric Bohm, Steven J MacDonald, Wade Gofton, Paul Kim, David Zukor, Susan Pleasance, Pantelis Andreou, Steve Doucette, Chris Theriault, Abongnwen Abianui, Marc Carrier, Michael J Kovacs, Marc A Rodger, Doug Coyle, Philip S Wells, Pascal-Andre Vendittoli
BACKGROUND: Clinical trials and meta-analyses have suggested that aspirin may be effective for the prevention of venous thromboembolism (proximal deep-vein thrombosis or pulmonary embolism) after total hip or total knee arthroplasty, but comparisons with direct oral anticoagulants are lacking for prophylaxis beyond hospital discharge. METHODS: We performed a multicenter, double-blind, randomized, controlled trial involving patients who were undergoing total hip or knee arthroplasty...
February 22, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29434266/future-global-productivity-will-be-affected-by-plant-trait-response-to-climate
#13
Nima Madani, John S Kimball, Ashley P Ballantyne, David L R Affleck, Peter M van Bodegom, Peter B Reich, Jens Kattge, Anna Sala, Mona Nazeri, Matthew O Jones, Maosheng Zhao, Steven W Running
Plant traits are both responsive to local climate and strong predictors of primary productivity. We hypothesized that future climate change might promote a shift in global plant traits resulting in changes in Gross Primary Productivity (GPP). We characterized the relationship between key plant traits, namely Specific Leaf Area (SLA), height, and seed mass, and local climate and primary productivity. We found that by 2070, tropical and arid ecosystems will be more suitable for plants with relatively lower canopy height, SLA and seed mass, while far northern latitudes will favor woody and taller plants than at present...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29432173/a-posttranslational-modification-of-the-mitotic-kinesin-eg5-that-enhances-its-mechanochemical-coupling-and-alters-its-mitotic-function
#14
Joseph M Muretta, Babu J N Reddy, Guido Scarabelli, Alex F Thompson, Shashank Jariwala, Jennifer Major, Monica Venere, Jeremy N Rich, Belinda Willard, David D Thomas, Jason Stumpff, Barry J Grant, Steven P Gross, Steven S Rosenfeld
Numerous posttranslational modifications have been described in kinesins, but their consequences on motor mechanics are largely unknown. We investigated one of these-acetylation of lysine 146 in Eg5-by creating an acetylation mimetic lysine to glutamine substitution (K146Q). Lysine 146 is located in the α2 helix of the motor domain, where it makes an ionic bond with aspartate 91 on the neighboring α1 helix. Molecular dynamics simulations predict that disrupting this bond enhances catalytic site-neck linker coupling...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29426358/optimizing-the-prescription-isodose-level-in-stereotactic-volumetric-modulated-arc-radiotherapy-of-lung-lesions-as-a-potential-for-dose-de-escalation
#15
Mark Chan, Matthew Wong, Ronnie Leung, Steven Cheung, Oliver Blanck
BACKGROUND: To derive and exploit the optimal prescription isodose level (PIL) in inverse optimization of volumetric modulated arc radiotherapy (VMAT) as a potential approach to dose de-escalation in stereotactic body radiotherapy for non-small cell lung carcinomas (NSCLC). METHODS: For ten patients, inverse Monte Carlo dose optimization was performed to cover 95% PTV by varying prescription isodose lines (PIL) at 60 to 80% and reference 85%. Subsequently, these were re-normalized to the median gross tumor volume dose (GTV-based prescription) to assess the impacts of PTV and normal tissue dose reduction...
February 9, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29401213/efficacy-and-safety-of-atx-101-by-treatment-session-pooled-analysis-of-data-from-the-phase-3-refine-trials
#16
Steven H Dayan, Joel Schlessinger, Kenneth Beer, Lisa M Donofrio, Derek H Jones, Shannon Humphrey, Jean Carruthers, Paul F Lizzul, Todd M Gross, Frederick C Beddingfield, Christine Somogyi
Background: ATX-101 (deoxycholic acid injection) is the only injectable drug approved for submental fat (SMF) reduction. In the phase 3 REFINE trials, adults with moderate or severe SMF who were dissatisfied with the appearance of their face/chin were eligible to receive up to 6 treatment sessions with ATX-101 (2 mg/cm2) or placebo. Primary and secondary endpoints, evaluated at 12 weeks after last treatment, significantly favored ATX-101 supporting its efficacy for reducing SMF and the psychological impact of SMF, and increasing satisfaction with the appearance of the face/chin...
February 1, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29341194/generation-of-red-drum-sciaenops-ocellatus-hematology-reference-intervals-with-a-focus-on-identified-outliers
#17
Kendal E Harr, Kristina Deak, Steven A Murawski, Drury R Reavill, Ryan A Takeshita
BACKGROUND: The Deepwater Horizon (DWH) oil spill in 2010 released millions of barrels of crude oil into the northern Gulf of Mexico, exposing numerous species of animals to the toxic components of oil. A comprehensive assessment of morbidity and mortality caused by DWH oil exposure was undertaken by the DWH Natural Resource Damage Trustees to characterize ecosystem damages. OBJECTIVES: This study aimed to characterize normal hematologic RIs in red drum fish with blood cell descriptions, and to demonstrate the importance of identifying and removing outliers when generating RI...
January 17, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29295928/cargo-navigation-across-3d-microtubule-intersections
#18
Jared P Bergman, Matthew J Bovyn, Florence F Doval, Abhimanyu Sharma, Manasa V Gudheti, Steven P Gross, Jun F Allard, Michael D Vershinin
The eukaryotic cell's microtubule cytoskeleton is a complex 3D filament network. Microtubules cross at a wide variety of separation distances and angles. Prior studies in vivo and in vitro suggest that cargo transport is affected by intersection geometry. However, geometric complexity is not yet widely appreciated as a regulatory factor in its own right, and mechanisms that underlie this mode of regulation are not well understood. We have used our recently reported 3D microtubule manipulation system to build filament crossings de novo in a purified in vitro environment and used them to assay kinesin-1-driven model cargo navigation...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29282640/high-incidence-of-recurrent-crohn-s-disease-following-colectomy-for-ulcerative-colitis-revealed-with-long-follow-up
#19
Steven Shamah, Judy Schneider, Burton I Korelitz
BACKGROUND AND AIMS: Ulcerative colitis (UC) patients with progression of their disease despite optimized medical therapy may warrant "curative" proctocolectomy with end ileostomy or ileo-anal pouch (IPAA) anastomosis. The aim of our study was to assess the incidence of later recurrent ileitis that lead to altering the initial diagnosis to Crohn's disease (CD). METHODS: A retrospective analysis was conducted on the inflammatory bowel disease database at Lenox Hill Hospital...
February 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29248365/monitoring-universal-health-coverage-within-the-sustainable-development-goals-development-and-baseline-data-for-an-index-of-essential-health-services
#20
Daniel R Hogan, Gretchen A Stevens, Ahmad Reza Hosseinpoor, Ties Boerma
BACKGROUND: Achieving universal health coverage, including quality essential service coverage and financial protection for all, is target 3.8 of the Sustainable Development Goals (SDG). As a result, an index of essential health service coverage indicators was selected by the UN as SDG indicator 3.8.1. We have developed an index for measuring SDG 3.8.1, describe methods for compiling the index, and report baseline results for 2015. METHODS: 16 tracer indicators were selected for the index, which included four from within each of the categories of reproductive, maternal, newborn, and child health; infectious disease; non-communicable diseases; and service capacity and access...
February 2018: Lancet Global Health
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