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https://www.readbyqxmd.com/read/29341194/generation-of-red-drum-sciaenops-ocellatus-hematology-reference-intervals-with-a-focus-on-identified-outliers
#1
Kendal E Harr, Kristina Deak, Steven A Murawski, Drury R Reavill, Ryan A Takeshita
BACKGROUND: The Deepwater Horizon (DWH) oil spill in 2010 released millions of barrels of crude oil into the northern Gulf of Mexico, exposing numerous species of animals to the toxic components of oil. A comprehensive assessment of morbidity and mortality caused by DWH oil exposure was undertaken by the DWH Natural Resource Damage Trustees to characterize ecosystem damages. OBJECTIVES: This study aimed to characterize normal hematologic RIs in red drum fish with blood cell descriptions, and to demonstrate the importance of identifying and removing outliers when generating RI...
January 17, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29295928/cargo-navigation-across-3d-microtubule-intersections
#2
Jared P Bergman, Matthew J Bovyn, Florence F Doval, Abhimanyu Sharma, Manasa V Gudheti, Steven P Gross, Jun F Allard, Michael D Vershinin
The eukaryotic cell's microtubule cytoskeleton is a complex 3D filament network. Microtubules cross at a wide variety of separation distances and angles. Prior studies in vivo and in vitro suggest that cargo transport is affected by intersection geometry. However, geometric complexity is not yet widely appreciated as a regulatory factor in its own right, and mechanisms that underlie this mode of regulation are not well understood. We have used our recently reported 3D microtubule manipulation system to build filament crossings de novo in a purified in vitro environment and used them to assay kinesin-1-driven model cargo navigation...
January 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29282640/high-incidence-of-recurrent-crohn-s-disease-following-colectomy-for-ulcerative-colitis-revealed-with-long-follow-up
#3
Steven Shamah, Judy Schneider, Burton I Korelitz
BACKGROUND AND AIMS: Ulcerative colitis (UC) patients with progression of their disease despite optimized medical therapy may warrant "curative" proctocolectomy with end ileostomy or ileo-anal pouch (IPAA) anastomosis. The aim of our study was to assess the incidence of later recurrent ileitis that lead to altering the initial diagnosis to Crohn's disease (CD). METHODS: A retrospective analysis was conducted on the inflammatory bowel disease database at Lenox Hill Hospital...
December 28, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29248365/monitoring-universal-health-coverage-within-the-sustainable-development-goals-development-and-baseline-data-for-an-index-of-essential-health-services
#4
Daniel R Hogan, Gretchen A Stevens, Ahmad Reza Hosseinpoor, Ties Boerma
BACKGROUND: Achieving universal health coverage, including quality essential service coverage and financial protection for all, is target 3.8 of the Sustainable Development Goals (SDG). As a result, an index of essential health service coverage indicators was selected by the UN as SDG indicator 3.8.1. We have developed an index for measuring SDG 3.8.1, describe methods for compiling the index, and report baseline results for 2015. METHODS: 16 tracer indicators were selected for the index, which included four from within each of the categories of reproductive, maternal, newborn, and child health; infectious disease; non-communicable diseases; and service capacity and access...
December 13, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/29236364/intraflagellar-transporter-protein-140-ift140-a-component-of-ift-a-complex-is-essential-for-male-fertility-and-spermiogenesis-in-mice
#5
Yong Zhang, Hong Liu, Wei Li, Zhengang Zhang, Shiyang Zhang, Maria E Teves, Courtney Stevens, James A Foster, Gregory E Campbell, Jolene J Windle, Rex A Hess, Gregory J Pazour, Zhibing Zhang
Intraflagellar transport (IFT) is a conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. However, little is known about its role in sperm flagella formation and male fertility. IFT140 is a component of IFT-A complex. In mouse, it is highly expressed in the testis. Ift140 gene was inactivated specifically in mouse spermatocytes/spermatids. The mutant mice did not show any gross abnormalities, but all were infertile associated with significantly reduced sperm number and motility...
December 13, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/29196525/mapping-local-and-global-variability-in-plant-trait-distributions
#6
Ethan E Butler, Abhirup Datta, Habacuc Flores-Moreno, Ming Chen, Kirk R Wythers, Farideh Fazayeli, Arindam Banerjee, Owen K Atkin, Jens Kattge, Bernard Amiaud, Benjamin Blonder, Gerhard Boenisch, Ben Bond-Lamberty, Kerry A Brown, Chaeho Byun, Giandiego Campetella, Bruno E L Cerabolini, Johannes H C Cornelissen, Joseph M Craine, Dylan Craven, Franciska T de Vries, Sandra Díaz, Tomas F Domingues, Estelle Forey, Andrés González-Melo, Nicolas Gross, Wenxuan Han, Wesley N Hattingh, Thomas Hickler, Steven Jansen, Koen Kramer, Nathan J B Kraft, Hiroko Kurokawa, Daniel C Laughlin, Patrick Meir, Vanessa Minden, Ülo Niinemets, Yusuke Onoda, Josep Peñuelas, Quentin Read, Lawren Sack, Brandon Schamp, Nadejda A Soudzilovskaia, Marko J Spasojevic, Enio Sosinski, Peter E Thornton, Fernando Valladares, Peter M van Bodegom, Mathew Williams, Christian Wirth, Peter B Reich
Our ability to understand and predict the response of ecosystems to a changing environment depends on quantifying vegetation functional diversity. However, representing this diversity at the global scale is challenging. Typically, in Earth system models, characterization of plant diversity has been limited to grouping related species into plant functional types (PFTs), with all trait variation in a PFT collapsed into a single mean value that is applied globally. Using the largest global plant trait database and state of the art Bayesian modeling, we created fine-grained global maps of plant trait distributions that can be applied to Earth system models...
December 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29184848/one-vs-three-fraction-pancreatic-stereotactic-body-radiation-therapy-for-pancreatic-carcinoma-single-institution-retrospective-review
#7
Philip Anthony Sutera, Mark E Bernard, Beant S Gill, Kamran K Harper, Kimmen Quan, Nathan Bahary, Steven A Burton, Herbert Zeh, Dwight E Heron
Background/introduction: Early reports of stereotactic body radiation therapy (SBRT) for pancreatic ductal adenocarcinoma (PDAC) used single fraction, but eventually shifted to multifraction regimens. We conducted a single institution review of our patients treated with single- or multifraction SBRT to determine whether any outcome differences existed. Methods and materials: Patients treated with SBRT in any setting for PDAC at our facility were included, from 2004 to 2014...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29169353/correction-to-long-term-patient-reported-outcomes-following-radiation-therapy-for-oropharyngeal-cancer-cross-sectional-assessment-of-a-prospective-symptom-survey-in-patients-%C3%A2-65%C3%A2-years-old
#8
Salman A Eraj, Mona K Jomaa, Crosby D Rock, Abdallah S R Mohamed, Blaine D Smith, Joshua B Smith, Theodora Browne, Luke C Cooksey, Bowman Williams, Brandi Temple, Kathryn E Preston, Jeremy M Aymard, Neil D Gross, Randal S Weber, Amy C Hessel, Renata Ferrarotto, Jack Phan, Erich M Sturgis, Ehab Y Hanna, Steven J Frank, William H Morrison, Ryan P Goepfert, Stephen Y Lai, David I Rosenthal, Tito R Mendoza, Charles S Cleeland, Kate A Hutcheson, Clifton D Fuller, Adam S Garden, G Brandon Gunn
In the original publication [1] the name of author Jeremy M. Aymard was spelled wrong. The original article was updated to rectify this error.
November 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29141214/partitioning-of-one-carbon-units-in-folate-and-methionine-metabolism-is-essential-for-neural-tube-closure
#9
Kit-Yi Leung, Yun Jin Pai, Qiuying Chen, Chloe Santos, Enrica Calvani, Sonia Sudiwala, Dawn Savery, Markus Ralser, Steven S Gross, Andrew J Copp, Nicholas D E Greene
Abnormal folate one-carbon metabolism (FOCM) is implicated in neural tube defects (NTDs), severe malformations of the nervous system. MTHFR mediates unidirectional transfer of methyl groups from the folate cycle to the methionine cycle and, therefore, represents a key nexus in partitioning one-carbon units between FOCM functional outputs. Methionine cycle inhibitors prevent neural tube closure in mouse embryos. Similarly, the inability to use glycine as a one-carbon donor to the folate cycle causes NTDs in glycine decarboxylase (Gldc)-deficient embryos...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29133888/neuronal-hyperactivity-due-to-loss-of-inhibitory-tone-in-apoe4-mice-lacking-alzheimer-s-disease-like-pathology
#10
Tal Nuriel, Sergio L Angulo, Usman Khan, Archana Ashok, Qiuying Chen, Helen Y Figueroa, Sheina Emrani, Li Liu, Mathieu Herman, Geoffrey Barrett, Valerie Savage, Luna Buitrago, Efrain Cepeda-Prado, Christine Fung, Eliana Goldberg, Steven S Gross, S Abid Hussaini, Herman Moreno, Scott A Small, Karen E Duff
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer's disease (AD). However, the reason APOE4 is associated with increased AD risk remains a source of debate. Neuronal hyperactivity is an early phenotype in both AD mouse models and in human AD, which may play a direct role in the pathogenesis of the disease. Here, we have identified an APOE4-associated hyperactivity phenotype in the brains of aged APOE mice using four complimentary techniques-fMRI, in vitro electrophysiology, in vivo electrophysiology, and metabolomics-with the most prominent hyperactivity occurring in the entorhinal cortex...
November 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29114596/clinical-outcomes-of-intensity-modulated-proton-therapy-and-concurrent-chemotherapy-in-esophageal-carcinoma-a-single-institutional-experience
#11
Anussara Prayongrat, Cai Xu, Heng Li, Steven H Lin
Purpose: Intensity-modulated proton therapy (IMPT) is an emerging advanced radiation technique. Although dosimetric studies demonstrate the superiority of IMPT for improving target conformity and reducing unnecessary dose to critical normal tissues, clinical experience is limited. We aim to describe our preliminary experience implementing IMPT concurrently with chemotherapy in esophageal carcinoma (EC). Methods and materials: From May 2011 through February 2016, 19 patients with EC (median age, 73 years) were treated with IMPT using 180 to 250 MV protons with a median dose of 50...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29108664/the-effect-of-acute-and-7-days-dietary-nitrate-on-mechanical-efficiency-exercise-performance-and-cardiac-biomarkers-in-patients-with-chronic-obstructive-pulmonary-disease
#12
Rosanne J H C G Beijers, Stephanie M D Huysmans, Coby van de Bool, Boris R M Kingma, Lex B Verdijk, Luc J C van Loon, Steven J R Meex, Harry R Gosker, Annemie M W J Schols
BACKGROUND & AIMS: Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD. METHODS: This double-blind, randomized cross-over placebo controlled trial included 20 mild-to-moderate COPD patients (66.6 ± 7.5 years) with moderate exercise impairments and decreased mechanical efficiency, normal BMI (26 ± 3 kg/m(2)) but high prevalence of abdominal obesity (83...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29101961/value-based-care-and-strategic-priorities
#13
REVIEW
Wendy L Gross, Lebron Cooper, Steven Boggs, Barbara Gold
The anesthesia market continues to undergo disruption. Financial margins are shrinking, and buyers are demanding that anesthesia services be provided in an efficient, low-cost manner. To help anesthesiologists analyze their market, Drucker and Porter's framework of buyers, suppliers, quality, barriers to entry, substitution, and strategic priorities allows for a structured analysis. Once this analysis is completed, anesthesiologists must articulate their value to other medical professionals and to hospitals...
December 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29101945/demands-of-integrated-care-delivery-in-interventional-medicine-and-anesthesiology-interdisciplinary-teamwork-and-strategy
#14
REVIEW
Wendy L Gross, Lebron Cooper, Steven Boggs
Evolving financial and medical constraints fueled by the increasing repertoire of nonoperating room cases and widening scope of patient comorbidities are discussed. The need to integrate finances and care approaches is detailed, and strategic suggestions for broader collaborative practice are suggested.
December 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29065921/fibroblast-bioenergetics-to-classify-amyotrophic-lateral-sclerosis-patients
#15
Csaba Konrad, Hibiki Kawamata, Kirsten G Bredvik, Andrea J Arreguin, Steven A Cajamarca, Jonathan C Hupf, John M Ravits, Timothy M Miller, Nicholas J Maragakis, Chadwick M Hales, Jonathan D Glass, Steven Gross, Hiroshi Mitsumoto, Giovanni Manfredi
BACKGROUND: The objective of this study was to investigate cellular bioenergetics in primary skin fibroblasts derived from patients with amyotrophic lateral sclerosis (ALS) and to determine if they can be used as classifiers for patient stratification. METHODS: We assembled a collection of unprecedented size of fibroblasts from patients with sporadic ALS (sALS, n = 171), primary lateral sclerosis (PLS, n = 34), ALS/PLS with C9orf72 mutations (n = 13), and healthy controls (n = 91)...
October 24, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29063809/thoracic-gamma-irradiation-induced-obesity-in-c57bl-6-female-mice
#16
Steven B Zhang, Shanmin Yang, Zhenhuan Zhang, Amy Zhang, Mei Zhang, Liangjie Yin, Katherine Casey-Sawicki, Steven Swarts, Sadasivan Vidyasagar, Lurong Zhang, Paul Okunieff
PURPOSE: To investigate the late effects of thoracic region irradiation (TRI) on mouse body weight. MATERIALS AND METHODS: Female C57BL/6 mice were divided into nonirradiated, 5 Gy total body irradiation, 9 Gy sub-total body irradiation, and 12.5 Gy thoracic region irradiation (TRI) groups. Changes in mouse weight were monitored every other week at similar time points for 12 months. The anatomical characteristics of abdominal visceral fat distribution were recorded, and mitochondrial DNA copy number in the hearts and livers and lipid metabolic signaling in the liver were analyzed...
October 24, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29055088/the-transcriptome-extracellular-proteome-and-active-secretome-of-agroinfiltrated-n-benthamiana-uncover-a-large-diverse-protease-repertoire
#17
Friederike Grosse-Holz, Steven Kelly, Svenja Blaskowski, Farnusch Kaschani, Markus Kaiser, Renier A L van der Hoorn
Infiltration of disarmed Agrobacterium tumefaciens into leaves of Nicotiana benthamiana (agroinfiltration) facilitates quick and safe production of antibodies, vaccines, enzymes and metabolites for industrial use (Molecular Farming). However, yield and purity of proteins produced by agroinfiltration are hampered by unintended proteolysis, restricting industrial viability of the agroinfiltration platform. Proteolysis may be linked to an immune response to agroinfiltration, but understanding of the response to agroinfiltration is limited...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29044788/management-of-the-lateral-neck-compartment-in-patients-with-sporadic-medullary-thyroid-cancer
#18
Israel Pena, Gary L Clayman, Elizabeth G Grubbs, Jeffrey M Bergeron, Steven G Waguespack, Maria E Cabanillas, Ramona Dadu, Mimi I Hu, Bryan M Fellman, Yisheng Li, Neil D Gross, Stephen Y Lai, Erich M Sturgis, Mark E Zafereo
BACKGROUND: The purpose of this retrospective analysis was to evaluate the benefits of an elective lateral neck dissection (ELND) in patients with medullary thyroid cancer (MTC) without radiographically apparent lateral neck metastases. METHODS: Patients with sporadic MTC without radiographic evidence of lateral neck metastasis who underwent definitive surgery were divided into 2 groups based on surgical approach: no ELND (the observation group) and ipsilateral or bilateral ELND (the ELND group)...
October 16, 2017: Head & Neck
https://www.readbyqxmd.com/read/29038867/correction-to-transethnic-insight-into-the-genetics-of-glycaemic-traits-fine-mapping-results-from-the-population-architecture-using-genomics-and-epidemiology-page-consortium
#19
Stephanie A Bien, James S Pankow, Jeffrey Haessler, Yinchang Lu, Nathan Pankratz, Rebecca R Rohde, Alfred Tamuno, Christopher S Carlson, Fredrick R Schumacher, Petra Bůžková, Martha L Daviglus, Unhee Lim, Myriam Fornage, Lindsay Fernandez-Rhodes, Larissa Avilés-Santa, Steven Buyske, Myron D Gross, Mariaelisa Graff, Carmen R Isasi, Lewis H Kuller, JoAnn E Manson, Tara C Matise, Ross L Prentice, Lynne R Wilkens, Sachiko Yoneyama, Ruth J F Loos, Lucia A Hindorff, Loic Le Marchand, Kari E North, Christopher A Haiman, Ulrike Peters, Charles Kooperberg
The authors regret that Yinchang Lu's name incorrectly included a middle initial in the author list. The details given in this erratum are correct.
October 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/29018025/peptidyl-prolyl-isomerase-1-regulates-ca-2-handling-by-modulating-sarco-endo-plasmic-reticulum-calcium-atpase-and-na-2-ca-2-exchanger-1-protein-levels-and-function
#20
Veronica Sacchi, Bingyan J Wang, Dieter Kubli, Alexander S Martinez, Jung-Kang Jin, Roberto Alvarez, Nirmala Hariharan, Christopher Glembotski, Takafumi Uchida, James S Malter, Yijun Yang, Polina Gross, Chen Zhang, Steven Houser, Marcello Rota, Mark A Sussman
BACKGROUND: Aberrant Ca(2+) handling is a prominent feature of heart failure. Elucidation of the molecular mechanisms responsible for aberrant Ca(2+) handling is essential for the development of strategies to blunt pathological changes in calcium dynamics. The peptidyl-prolyl cis-trans isomerase peptidyl-prolyl isomerase 1 (Pin1) is a critical mediator of myocardial hypertrophy development and cardiac progenitor cell cycle. However, the influence of Pin1 on calcium cycling regulation has not been explored...
October 10, 2017: Journal of the American Heart Association
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