keyword
https://read.qxmd.com/read/38534720/antimicrobial-and-diagnostic-stewardship-of-the-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-for-infections-due-to-carbapenem-resistant-enterobacterales-species-and-pseudomonas-aeruginosa
#1
REVIEW
Stefanos Ferous, Cleo Anastassopoulou, Vassiliki Pitiriga, Georgia Vrioni, Athanasios Tsakris
Carbapenem-resistant Gram-negative bacterial infections are a major public health threat due to the limited therapeutic options available. The introduction of the new β-lactam/β-lactamase inhibitors (BL/BLIs) has, however, altered the treatment options for such pathogens. Thus, four new BL/BLI combinations-namely, ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam, and ceftolozane/tazobactam-have been approved for infections attributed to carbapenem-resistant Enterobacterales species and Pseudomonas aeruginosa ...
March 21, 2024: Antibiotics
https://read.qxmd.com/read/38534711/sub-mic-antibiotics-modulate-productions-of-outer-membrane-vesicles-in-tigecycline-resistant-escherichia-coli
#2
JOURNAL ARTICLE
Qianru Li, Jun Li, Tao He, Xing Ji, Ruicheng Wei, Meiling Yu, Ran Wang
Antimicrobial resistance (AMR) has been recognized as one of the most important crises affecting global human health in the 21st century. Tigecycline is one of the last resort antibiotics for treating severe infections caused by multi-drug resistant Enterobacteriaceae . However, the mobile resistance gene tet (X4), which could mediate high-level tigecycline resistance, was discovered in 2019. The outer membrane vesicle (OMV) has been recognized as a new route for horizontal gene transfer; antimicrobial resistant bacteria also have the ability to secret OMVs, while little is known about the impact of antibiotics on the secretion and characteristics of OMVs from tigecycline resistant bacteria till now...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534710/phenotypic-and-genotypic-characterization-of-pan-drug-resistant-klebsiella-pneumoniae-isolated-in-qatar
#3
JOURNAL ARTICLE
Mazen A Sid Ahmed, Jemal M Hamid, Ahmed M M Hassan, Sulieman Abu Jarir, Emad Bashir Ibrahim, Hamad Abdel Hadi
In secondary healthcare, carbapenem-resistant Enterobacterales (CREs), such as those observed in Klebsiella pneumoniae , are a global public health priority with significant clinical outcomes. In this study, we described the clinical, phenotypic, and genotypic characteristics of three pan-drug-resistant (PDR) isolates that demonstrated extended resistance to conventional and novel antimicrobials. All patients had risk factors for the acquisition of multidrug-resistant organisms, while microbiological susceptibility testing showed resistance to all conventional antimicrobials...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534700/the-clinical-efficacy-of-adding-ceftazidime-avibactam-to-standard-therapy-in-treating-infections-caused-by-carbapenem-resistant-klebsiella-pneumonia-with-blaoxa-48-like-genes
#4
JOURNAL ARTICLE
Al Maamon R Abu Jaber, Bilgen Basgut, Ali Abdullah Hawan, Ali Amer Al Shehri, Sultan Ahmad AlKahtani, Nehad J Ahmed, Abdikarim Abdi
Ceftazidime/avibactam (CAZ-AVI) is FDA-approved for managing infections caused by resistant gram-negative bacilli, particularly infections via carbapenem-resistant Enterobacterales pathogens. The clinical data are still limited, particularly those in Saudi Arabia. The present study is a retrospective cohort study that was carried out at the Armed Forces Hospital in the southern region of Saudi Arabia to compare the clinical and microbiological outcomes for CAZ-AVI-treated patients as monotherapy and as an add-on to standard therapy for carbapenem-resistant Klebsiella pneumonia (CRKP) OXA-48 infections to those treated with standard drugs...
March 16, 2024: Antibiotics
https://read.qxmd.com/read/38531847/antimicrobial-resistance-burden-pre-and-post-covid-19-pandemic-with-mapping-the-multidrug-resistance-in-egypt-a-comparative-cross-sectional-study
#5
JOURNAL ARTICLE
Shaimaa Abdelaziz Abdelmoneim, Ramy Mohamed Ghazy, Eman Anwar Sultan, Mahmoud A Hassaan, Mohamed Anwar Mahgoub
Overuse of antibiotics during coronavirus disease 2019 (COVID-19) in an attempt to reduce COVID-19 mortality in the short term may have contributed to long-term mortality from antimicrobial resistance (AMR). The aim of this study was to evaluate the impact of the COVID-19 pandemic on AMR in Egypt and map the distribution of multidrug-resistant (MDR) and extensive drug-resistant (XDR) across Egypt. Through a multicenter cross-sectional study 2430 culture results were collected in 2019 and 2022 pre and post-COVID-19 pandemic in Egypt, including 400 Klebsiella pneumoniae, 760 Escherichia coli, 650 Acinetobacter baumannii, and 620 Methicillin-resistant staphylococcus aureus (MRSA) culture results...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38529473/spectrum-and-antibiotic-sensitivity-of-bacterial-keratitis-a-retrospective-analysis-of-eight-years-in-a-tertiary-referral-hospital-in-southwest-china
#6
JOURNAL ARTICLE
Rui-Qin Guo, Ji Yang, Ya-Bin Yang, Ya-Nan Chen, Yu-Yuan Xiao, Ping Xiang, Meng-Jie Dong, Min-Fang He, Yin-Ting Wang, Yun-Ling Xiao, Hong-Qin Ke, Hai Liu
PURPOSE: The objective of this study was to investigate the epidemiological characteristics, distribution of isolates, prevailing patterns, and antibiotic susceptibility of bacterial keratitis (BK) in a Tertiary Referral Hospital located in Southwest China. METHODS: A retrospective analysis was conducted on 660 cases of bacterial keratitis occurring between January 2015 and December 2022. The demographic data, predisposing factors, microbial findings, and antibiotic sensitivity profiles were examined...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38528442/in-vitro-investigation-of-relationship-between-quorum-sensing-system-genes-biofilm-forming-ability-and-drug-resistance-in-clinical-isolates-of-pseudomonas-aeruginosa
#7
JOURNAL ARTICLE
Jaber Hemmati, Mohsen Nazari, Fatemeh Sadat Abolhasani, Amjad Ahmadi, Babak Asghari
BACKGROUND: Pseudomonas aeruginosa is an opportunistic pathogen in the health-care systems and one of the primary causative agents with high mortality in hospitalized patients, particularly immunocompromised. The limitation of effective antibiotic administration in multidrug-resistant and extensively drug-resistant P. aeruginosa isolates leads to the development of nosocomial infections and health problems. Quorum sensing system contributes to biofilm formation, expression of bacterial virulence factors, and development of drug resistance, causing prolonged patient infections...
March 25, 2024: BMC Microbiology
https://read.qxmd.com/read/38526879/synergistic-effects-of-ceftazidime-avibactam-combined-with-meropenem-in-a-murine-model-of-infection-with-kpc-producing-klebsiella-pneumoniae
#8
JOURNAL ARTICLE
Mei Zheng, Fu-Hao Li, Juan Liu, Wen-Jie Li, Ruo-Xi Yin, Da-Tong Cai, Diego O Andrey, Si-Lin Zheng, Ana C Gales, Wan-Jiang Zhang, Jian Sun, Xiao-Ping Liao, Yang Yu
OBJECTIVES: The emergence and expansion of carbapenem-resistant Klebsiella pneumoniae infections is a concern due to the lack of 'first-line' antibiotic treatment options. The ceftazidime/avibactam is an important clinical treatment for carbapenem-resistant K. pneumoniae infections but there is an increasing number of cases of treatment failure and drug resistance. Therefore, a potential solution is combination therapies that result in synergistic activity against K. pneumoniae carbapenemase: producing K...
March 25, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38526050/-in-vitro-development-of-resistance-against-antipseudomonal-agents-comparison-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations-and-other-%C3%AE-lactam-agents
#9
JOURNAL ARTICLE
Mariana Castanheira, John H Kimbrough, Jill Lindley, Timothy B Doyle, Jessica M Ewald, Helio S Sader
We subjected seven P . aeruginosa isolates to a 10-day serial passaging against five antipseudomonal agents to evaluate resistance levels post-exposure and putative resistance mechanisms in terminal mutants were analyzed by whole-genome sequencing analysis. Meropenem (mean, 38-fold increase), cefepime (14.4-fold), and piperacillin-tazobactam (52.9-fold) terminal mutants displayed high minimum inhibitory concentration (MIC) values compared to those obtained after exposure to ceftolozane-tazobactam (11.4-fold) and ceftazidime-avibactam (5...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38523732/carbapenem-resistant-enterobacterales-among-hospitalized-patients-in-cape-town-south-africa-clinical-and-microbiological-epidemiology
#10
JOURNAL ARTICLE
Hafsah Deepa Tootla, Elizabeth Prentice, Clinton Moodley, Gert Marais, Nyasha Nyakutira, Kessendri Reddy, Colleen Bamford, Abraham Niehaus, Andrew Whitelaw, Adrian Brink
BACKGROUND: Carbapenem-resistant Enterobacterales (CRE) are a substantial problem in Cape Town. CRE epidemiology is largely unknown and mortality remains high. OBJECTIVES: To describe and characterize the clinical and microbiological epidemiology of CRE within Cape Town hospitals to better inform therapy with regard to current and novel antibiotics, as well as improve antimicrobial stewardship (AMS), and infection prevention and control (IPC). METHODS: This prospective, multicentre study performed between 1 November 2020 and 30 November 2022, across three public and three private hospitals included hospitalized participants with CRE from clinical cultures...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38519025/simultaneous-post-neurosurgical-ventriculitis-and-bacteremia-by-two-different-strains-of-kpc-producing-k-pneumoniae-successfully-treated-with-meropenem-vaborbactam-and-high-dose-of-fosfomycin
#11
JOURNAL ARTICLE
Lorenzo Volpicelli, Sara Cairoli, Dania Al Ismail, Floriana Baisi, Federica Sacco, Bianca Maria Goffredo, Mario Venditti, Alessandra Oliva
A case of post-neurosurgical ventriculitis caused by a KPC-producing Klebsiella pneumoniae (KPC-Kp) with a ceftazidime/avibactam-resistant, meropenem-susceptible phenotype is reported. The patient had a concomitant bloodstream infection with a wild-type KPC-Kp with a ceftazidime/avibactam-susceptible, meropenem-resistant phenotype. Prolonged treatment with intravenous fosfomycin and meropenem/vaborbactam achieved clinical success. Therapeutic drug monitoring performed during the first days of treatment showed for the first time that vaborbactam efficiently penetrates cerebrospinal fluid...
March 20, 2024: Journal of Global Antimicrobial Resistance
https://read.qxmd.com/read/38517189/transferable-ampcs-in-klebsiella-pneumoniae-interplay-with-peptidoglycan-recycling-mechanisms-of-hyperproduction-and-virulence-implications
#12
JOURNAL ARTICLE
Isabel M Barceló, Maria Escobar-Salom, Gabriel Cabot, Pau Perelló-Bauzà, Elena Jordana-Lluch, Biel Taltavull, Gabriel Torrens, Estrella Rojo-Molinero, Laura Zamorano, Astrid Pérez, Antonio Oliver, Carlos Juan
Chromosomal and transferable AmpC β-lactamases represent top resistance mechanisms in different gram-negatives, but knowledge regarding the latter, mostly concerning regulation and virulence-related implications, is far from being complete. To fill this gap, we used Klebsiella pneumoniae (KP) and two different plasmid-encoded AmpCs [DHA-1 (AmpR regulator linked, inducible) and CMY-2 (constitutive)] as models to perform a study in which we show that blockade of peptidoglycan recycling through AmpG permease inactivation abolished DHA-1 inducibility but did not affect CMY-2 production and neither did it alter KP pathogenic behavior...
March 22, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38516722/-lactococcus-garvieae-associated-septicemia-in-a-central-bearded-dragon
#13
JOURNAL ARTICLE
Christian M Capobianco, Sarah N Bosch, Nicole I Stacy, James F X Wellehan
Lactococcus garvieae is the causative agent of lactococcosis in fish and an emerging zoonotic pathogen with high levels of antimicrobial resistance. We report a case of L. garvieae- associated septicemia in a central bearded dragon ( Pogona vitticeps ) confirmed via whole-blood PCR and direct sequencing. Following a 30-d course of ceftazidime (20 mg/kg IM q72h), the animal's clinical condition had not resolved; leukopenia persisted, with heterophil toxic change. Coelomic ultrasound findings were consistent with preovulatory follicular stasis, folliculitis, and coelomitis...
March 22, 2024: Journal of Veterinary Diagnostic Investigation
https://read.qxmd.com/read/38515868/rates-of-resistance-and-heteroresistance-to-newer-%C3%AE-lactam-%C3%AE-lactamase-inhibitors-for-carbapenem-resistant-enterobacterales
#14
JOURNAL ARTICLE
Christina K Lin, Alex Page, Sarah Lohsen, Ali A Haider, Jesse Waggoner, Gillian Smith, Ahmed Babiker, Jesse T Jacob, Jessica Howard-Anderson, Sarah W Satola
BACKGROUND: Heteroresistance (HR), the presence of antibiotic-resistant subpopulations within a primary isogenic population, may be a potentially overlooked contributor to newer β-lactam/β-lactamase inhibitor (BL/BLI) treatment failure in carbapenem-resistant Enterobacterales (CRE) infections. OBJECTIVES: To determine rates of susceptibility and HR to BL/BLIs ceftazidime/avibactam, imipenem/relebactam and meropenem/vaborbactam in clinical CRE isolates...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38513748/activity-of-cefiderocol-and-innovative-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations-against-isogenic-strains-of-escherichia-coli-expressing-single-and-double-%C3%AE-lactamases-under-high-and-low-permeability-conditions
#15
JOURNAL ARTICLE
Tania Blanco-Martín, Isaac Alonso-García, Lucía González-Pinto, Michelle Outeda-García, Paula Guijarro-Sánchez, Inmaculada López-Hernández, María Pérez-Vázquez, Belén Aracil, Lorena López-Cerero, Pablo Fraile-Ribot, Antonio Oliver, Juan Carlos Vázquez-Ucha, Alejandro Beceiro, Germán Bou, Jorge Arca-Suárez
OBJECTIVES: To analyze the impact of the most clinically relevant β-lactamases and their interplay with low outer membrane permeability on the activity of cefiderocol, ceftazidime/avibactam, aztreonam/avibactam, cefepime/enmetazobactam, cefepime/taniborbactam, cefepime/zidebactam, imipenem/relebactam, meropenem/vaborbactam, meropenem/xeruborbactam and meropenem/nacubactam against recombinant E. coli strains. METHODS: We constructed 82 Escherichia coli laboratory transformants expressing the main β-lactamases circulating in Enterobacterales (70 expressing single β-lactamase and 12 producing double carbapenemase) under high (E...
March 19, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38513747/efficacy-of-ceftazidime-avibactam-in-the-treatment-of-carbapenem-resistant-klebsiella-pneumoniae-infections-focus-on-solid-organ-transplantation-recipients
#16
JOURNAL ARTICLE
Juan Hu, Lei Zha, Yong-Wei Yu, Qun Su, Xue-Ling Fang, Jin-Ru Ji, Ping Shen, Yun- Bo Chen, Xia Zheng, Yong-Hong Xiao
INTRODUCTION: Ceftazidime-avibactam (CAZ-AVI) is a new option to treat KPC- and OXA-48 carbapenem-resistant Klebsiella pneumoniae (CRKP) infections. However, clinical evidence is limited regarding its use in treating CRKP infections, especially in solid organ transplantation (SOT) recipients. In this study, we assessed the efficacy of CAZ-AVI in treating CRKP infections in both the general population and the SOT recipients in comparison with other antibiotic regimens. METHODS: This is a single-center retrospective cohort study of patients admitted between January 1, 2018 and June 30, 2021 with the diagnosis of CRKP infections receiving either CAZ-AVI or other regimens ≥ 72 hours and clinical outcomes were analyzed...
March 19, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38510907/effectiveness-of-ceftazidime-avibactam-in-gram-negative-nosocomial-pneumonia-a-real-world-study-in-india
#17
JOURNAL ARTICLE
Neha Gupta, Sanjith Saseedharan, Yashesh Paliwal
BACKGROUND AND OBJECTIVE: The incidences of nosocomial pneumonia in intensive care units (ICUs) in India have been reported to range from 9% to 58% and are associated with a mortality rate of 30-70%. Ceftazidime-avibactam has activity against OXA-48-like carbapenem-resistant Enterobacterales (CRE) and has a safer adverse effect profile as compared to the nephrotoxic colistin. The current study aimed to assess the effectiveness and usage pattern of ceftazidime-avibactam in gram-negative hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) in real-world settings in India...
February 2024: Curēus
https://read.qxmd.com/read/38508537/spread-and-evolution-of-bla-kpc-plasmid-between-serratia-marcescens-and-klebsiella-pneumoniae
#18
JOURNAL ARTICLE
Weiwei Yang, Chengkang Tang, Siquan Shen, Qingyu Shi, Fupin Hu
The emergence and prevalence of carbapenem-resistant Enterobacterales on a global scale has posed a serious challenge to global public health security. Clinical research has rarely reported the co-infection of multidrug-resistant Serratia marcescens and Klebsiella pneumoniae. In this study, we describe the case of a hospitalized patient infected with carbapenem-resistant S. marcescens and K. pneumoniae. The evolution and transmission of blaKPC-2 occurred during the treatment with ceftazidime-avibactam and trimethoprim-sulfamethoxazole...
March 18, 2024: International Journal of Antimicrobial Agents
https://read.qxmd.com/read/38506533/outbreak-of-ndm-5-producing-klebsiella-pneumoniae-st307-an-emerging-high-risk-antimicrobial-resistance-clone-in-shanghai-china
#19
JOURNAL ARTICLE
Junying Zhu, Guangyu Wang, Min Li
The high-risk clone Klebsiella pneumoniae ST307, associated with various carbapenem resistance genes, exhibits a global distribution and prevalence. However, in China, it has remained sporadic and has rarely been detected. In this study, we reported an outbreak caused by nine ST307 CRKP isolates harboring bla NDM-5 in Shanghai, China, in 2022. We employed antimicrobial susceptibility testing, conjugation assay, whole-genome sequencing (WGS) and comparative genomics, phylogenetic analysis, and fitness and virulence comparison to further characterize the isolates causing the outbreak...
March 20, 2024: MSystems
https://read.qxmd.com/read/38505552/activities-of-aztreonam-in-combination-with-several-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations-against-carbapenem-resistant-klebsiella-pneumoniae-strains-coproducing-kpc-and-ndm
#20
JOURNAL ARTICLE
Xinhui Li, Jisheng Zhang, Jianmin Wang, Wenzhang Long, Xushan Liang, Yang Yang, Xue Gong, Jie Li, Longjin Liu, Xiaoli Zhang
Isolates coproducing serine/metallo-carbapenems are a serious emerging public health threat, given their rapid dissemination and the limited number of treatment options. The purposes of this study were to evaluate the in vitro antibacterial activity of novel β-lactam-β-lactamase inhibitor combinations (BLBLIs) against carbapenem-resistant Klebsiella pneumoniae (CRKP) coproducing metallo-β-lactamase and serine-β-lactamase, and to explore their effects in combination with aztreonam, meropenem, or polymyxin in order to identify the best therapeutic options...
2024: Frontiers in Microbiology
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