Tania Blanco-Martín, Isaac Alonso-García, Lucía González-Pinto, Michelle Outeda-García, Paula Guijarro-Sánchez, Inmaculada López-Hernández, María Pérez-Vázquez, Belén Aracil, Lorena López-Cerero, Pablo Fraile-Ribot, Antonio Oliver, Juan Carlos Vázquez-Ucha, Alejandro Beceiro, Germán Bou, Jorge Arca-Suárez
OBJECTIVES: To analyze the impact of the most clinically relevant β-lactamases and their interplay with low outer membrane permeability on the activity of cefiderocol, ceftazidime/avibactam, aztreonam/avibactam, cefepime/enmetazobactam, cefepime/taniborbactam, cefepime/zidebactam, imipenem/relebactam, meropenem/vaborbactam, meropenem/xeruborbactam and meropenem/nacubactam against recombinant E. coli strains. METHODS: We constructed 82 Escherichia coli laboratory transformants expressing the main β-lactamases circulating in Enterobacterales (70 expressing single β-lactamase and 12 producing double carbapenemase) under high (E...
March 19, 2024: International Journal of Antimicrobial Agents