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https://www.readbyqxmd.com/read/27703513/clinical-characteristics-of-drug-induced-liver-injury-and-related-risk-factors
#1
Ren-Jie Lu, Yan Zhang, Feng-Lei Tang, Zhong-Wei Zheng, Zheng-Da Fan, Shan-Mei Zhu, Xian-Feng Qian, Na-Na Liu
Drug-induced liver injury (DILI) is often undiagnosed or misdiagnosed clinically because of diagnostic difficulties caused by lack of laboratory-specific serological markers. In this study, we comprehensively assessed the clinical characteristics, laboratory indices, hepatotoxic drugs, risk factors and outcomes concerning DILI, and explored the similarities in mechanisms between Chinese and Western drug-induced DILI. Patients with a first diagnosis of DILI and a Roussel Uclaf Causality Assessment Method (RUCAM) score >3 points were enrolled for systematic retrospective study...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27651817/systematic-review-on-chinese-herbal-medicine-induced-liver-injury
#2
REVIEW
Peng Zhang, Yongan Ye, Xianzhao Yang, Yuntao Jiao
Background. In recent years, with the popularity of CHM, its hepatotoxicity has also been increasingly noticed. However, there are still veils on causative herbs and clinical characteristics. Aim. To systematically review data on CHM induced liver injury with particular focus on causative herbs and clinical characteristics. Methods. Using terms related to CHM and liver injury, PubMed and three Chinese electronic databases were searched, which was limited to the past 5 years. Publications meeting our eligibility criteria were included and further analyzed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27128912/herbal-hepatotoxicity-clinical-characteristics-and-listing-compilation
#3
REVIEW
Christian Frenzel, Rolf Teschke
Herb induced liver injury (HILI) and drug induced liver injury (DILI) share the common characteristic of chemical compounds as their causative agents, which were either produced by the plant or synthetic processes. Both, natural and synthetic chemicals are foreign products to the body and need metabolic degradation to be eliminated. During this process, hepatotoxic metabolites may be generated causing liver injury in susceptible patients. There is uncertainty, whether risk factors such as high lipophilicity or high daily and cumulative doses play a pathogenetic role for HILI, as these are under discussion for DILI...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27091053/diagnosis-and-management-of-drug-induced-liver-injury-dili-in-patients-with-pre-existing-liver-disease
#4
REVIEW
Rolf Teschke, Gaby Danan
The relationship between drugs and pre-existing liver disease is complex, particularly when increased liver tests (LTs) or new symptoms emerge in patients with pre-existing liver disease during drug therapy. This requires two strategies to assess whether these changes are due to drug-induced liver injury (DILI) as a new event or due to flares of the underlying liver disease. Lacking a valid diagnostic biomarker, DILI is a diagnosis of exclusion and requires causality assessment by RUCAM, the Roussel Uclaf Causality Assessment Method, to establish an individual causality grading of the suspected drug(s)...
August 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27043544/the-honolulu-liver-disease-cluster-at-the-medical-center-its-mysteries-and-challenges
#5
REVIEW
Rolf Teschke, Axel Eickhoff
In 2013, physicians at the Honolulu Queen's Medical Center (QMC) noticed that seven liver disease patients reported the use of OxyELITE Pro (OEP), a widely consumed dietary supplement (DS). Assuming a temporal association between OEP use and disease, they argued that OEP was the cause of this mysterious cluster. Subsequent reexamination, however, has revealed that this QMC cohort is heterogeneous and not a cluster with a single agent causing a single disease. It is heterogeneous because patients used multiple DS's and drugs and because patients appeared to have suffered from multiple liver diseases: liver cirrhosis, liver failure by acetaminophen, hepatotoxicity by non-steroidal antiinflammatory drugs (NSAIDs), resolving acute viral hepatitis by hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella zoster virus (VZV), and suspected hepatitis E virus (HEV)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26955676/-analysis-of-clinical-characteristics-in-595-patients-with-herb-induced-liver-injury
#6
Yun Zhu, Yong-gang Li, Yao Wang, Li-ping Wang, Jia-bo Wang, Rui-lin Wang, Li-fu Wang, Ya-kun Meng, Zhong-xia Wang, He Xiao Xiao
OBJECTIVE: To observe clinical characteristics of herb-induced liver injury (HILI). METHODS: General conditions, medical history, clinical manifestations, biochemical indices, prognosis, and Roussed Uclaf Causality Assessment Method (RUCAM) scores were retrospectively analyzed in 595 inpatients at 302 Military Hospital between January 2009 and January 2014. RESULTS: There were 423 cases (accounting for 71.1%) were females with multiple onset age ranging 41 to 50 years old...
January 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/26712744/rucam-in-drug-and-herb-induced-liver-injury-the-update
#7
REVIEW
Gaby Danan, Rolf Teschke
RUCAM (Roussel Uclaf Causality Assessment Method) or its previous synonym CIOMS (Council for International Organizations of Medical Sciences) is a well established tool in common use to quantitatively assess causality in cases of suspected drug induced liver injury (DILI) and herb induced liver injury (HILI). Historical background and the original work confirm the use of RUCAM as single term for future cases, dismissing now the term CIOMS for reasons of simplicity and clarity. RUCAM represents a structured, standardized, validated, and hepatotoxicity specific diagnostic approach that attributes scores to individual key items, providing final quantitative gradings of causality for each suspect drug/herb in a case report...
December 24, 2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26598920/drug-induced-liver-injury-a-2-year-retrospective-study-of-1169-hospitalized-patients-in-a-single-medical-center
#8
Hong Jung Woo, Ha Yeon Kim, Eun Sol Choi, Young-Hwan Cho, Youngchul Kim, Jang-Hoon Lee, Eungyeong Jang
BACKGROUND: Although herbal medicines (HMs) are widely used in Asian and Western countries, medicinal information concerning their hepatic toxicity or interaction with conventional medicines (CMs) is sparse. PURPOSE: The aim of our study was to estimate the prevalence of drug-induced liver injury (DILI) among total inpatients prescribed HMs or CMs. Furthermore, we noted all medications suspected to be associated with hepatotoxicity in the liver injury group during the period of hospitalization...
December 1, 2015: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26597192/a-text-searching-tool-to-identify-patients-with-idiosyncratic-drug-induced-liver-injury
#9
Lauren Heidemann, James Law, Robert J Fontana
BACKGROUND: Idiosyncratic drug-induced liver injury (DILI) is an uncommon but important cause of liver disease that is challenging to diagnose and identify in the electronic medical record (EMR). AIM: To develop an accurate, reliable, and efficient method of identifying patients with bonafide DILI in an EMR system. METHODS: In total, 527,000 outpatient and ER encounters in an EPIC-based EMR were searched for potential DILI cases attributed to eight drugs...
November 23, 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26560492/a-case-of-hepatotoxicity-induced-by-adulterated-tiger-king-a-chinese-herbal-medicine-containing-sildenafil
#10
Ran Nissan, Alina Poperno, Gideon Y Stein, Barak Shapira, Shmuel Fuchs, Ronny Berkovitz, Zipora Hess, Mickey Arieli
Detection of Phosphodiesterase Type 5 (PDE-5) inhibitors and their analogues in "100% natural" or "herbal" supplements have been described in numerous reports. However, few reports have been published in relation to actual harm caused by counterfeit erectile dysfunction herbal supplements. We describe a case of a 65-year old male admitted to a tertiary hospital with acute liver toxicity, possibly induced by adulterated "Chinese herbal" supplement "Tiger King" for sexual enhancement. Chemical analysis of the tablets discovered the presence of therapeutic doses of sildenafil with no other herbal components...
2016: Current Drug Safety
https://www.readbyqxmd.com/read/26159261/how-to-diagnose-and-exclude-drug-induced-liver-injury
#11
Paul B Watkins
The diagnosis of drug-induced liver injury (DILI) is largely a diagnosis of exclusion because, with the possible exception of protein:drug adducts in paracetamol overdose, there are no laboratory, biopsy or imaging tests that alone are capable of establishing an unequivocal diagnosis of DILI. However, it is increasingly appreciated that drugs that cause DILI typically have characteristic clinical presentations or 'signatures' that can be very useful in the diagnosis of DILI. Indeed, knowing a drug's DILI signature (or sometimes signatures) and the incidence rate of DILI during treatment with that drug are perhaps the most useful pieces of historical information in arriving at the diagnosis of DILI...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/26104271/cyproterone-acetate-induces-a-wide-spectrum-of-acute-liver-damage-including-corticosteroid-responsive-hepatitis-report-of-22-cases
#12
Fernando Bessone, M I Lucena, Marcelo G Roma, Camilla Stephens, Inmaculada Medina-Cáliz, Bernardo Frider, Guillermo Tsariktsian, Nelia Hernández, Miquel Bruguera, Gisela Gualano, Eduardo Fassio, Joaquín Montero, María V Reggiardo, Sebastián Ferretti, Luis Colombato, Federico Tanno, Jaime Ferrer, Lelio Zeno, Hugo Tanno, Raúl J Andrade
BACKGROUND & AIMS: Cyproterone acetate (CPA), an anti-androgenic drug for prostate cancer, has been associated with drug-induced liver injury (DILI). We aim to expand the knowledge on the spectrum of phenotypes and outcomes of CPA-induced DILI. METHODS: Twenty-two males (70 ± 8 years; range 54-83) developing liver damage as a result of CPA therapy (dose: 150 ± 50 mg/day; range 50-200) were included. Severity index and causality by RUCAM were assessed. RESULTS: From 1993 to 2013, 22 patients were retrieved...
February 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/26045135/monocyte-derived-hepatocyte-like-cells-for-causality-assessment-of-idiosyncratic-drug-induced-liver-injury
#13
Andreas Benesic, Alexandra Leitl, Alexander L Gerbes
BACKGROUND: Idiosyncratic drug-induced liver injury (iDILI) is a frequent cause of acute liver injury and a serious problem in late stage drug-development. Its diagnosis is one of the most challenging in hepatology, since it is done by exclusion and relies on expert opinion. Until now no reliable in vitro test exists to support the diagnosis of iDILI. In some instances it is impossible to determine the causative drug in polymedicated patients. AIM: To investigate if monocyte-derived hepatocyte-like (MH) cells might be a tool supporting clinical judgment for iDILI diagnosis and causality assessment...
September 2016: Gut
https://www.readbyqxmd.com/read/25975988/hepatotoxicity-of-green-tea-an-update
#14
REVIEW
Gabriela Mazzanti, Antonella Di Sotto, Annabella Vitalone
Green tea (GT), obtained from the leaves of Camellia sinensis (L.) Kuntze (Fam. Theaceae), is largely used for its potential health benefits such as reduction in risk of cardiovascular diseases and weight loss. Nevertheless, it is suspected to induce liver damage. Present work reviews the hepatic adverse reactions associated with GT-based herbal supplements, published by the end of 2008 to March 2015. A systematic research was carried out on PubMed, MedlinePlus, Scopus and Google Scholar databases, without any language restriction...
August 2015: Archives of Toxicology
https://www.readbyqxmd.com/read/25920181/-case-reports-of-drug-induced-liver-injury-in-a-reference-hospital-of-zulia-state-venezuela
#15
Edgardo Mengual-Moreno, Maribel Lizarzábal-García, María Ruiz-Soler, Niniveth Silva-Suarez, Raúl Andrade-Bellido, Maribel Lucena-González, Fernando Bessone, Nelia Hernández, Adriana Sánchez, Inmaculada Medina-Cáliz
Drug-induced liver injury (DILI) is an important cause of morbidity and mortality worldwide, with varied geographical differences. The aim of this prospective, descriptive, cross-sectional study was to identify and characterize cases of DILI in a hospital of Zulia state, Venezuela. Thirteen patients with a presumptive diagnosis of DILI attended by the Department of Gastroenterology, Hospital Universitario, Zulia state, Venezuela, from December-2012 to December-2013 were studied. Ibuprofen (n = 3; 23.1%), acetaminophen (n = 3; 23...
March 2015: Investigación Clínica
https://www.readbyqxmd.com/read/25756190/new-onset-idiosyncratic-liver-enzyme-elevations-with-biological-therapy-in-inflammatory-bowel-disease
#16
E Shelton, K Chaudrey, J Sauk, H Khalili, R Masia, D D Nguyen, V Yajnik, A N Ananthakrishnan
BACKGROUND: Anti-tumour necrosis factor α (anti-TNF) agents have been implicated in drug-induced liver injury. There is minimal data on this occurrence in inflammatory bowel disease (IBD) patients. AIM: To identify the characteristics of liver enzyme elevations following anti-TNF therapy initiation in IBD. METHODS: A retrospective cohort of patients initiating anti-TNF therapy were analysed for new onset alanine transaminase (ALT) elevation (≥60 U/L)...
May 2015: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/25688317/liver-transplant-in-a-patient-under-methylphenidate-therapy-a-case-report-and-review-of-the-literature
#17
Hoi Y Tong, Carmen Díaz, Elena Collantes, Nicolás Medrano, Alberto M Borobia, Paloma Jara, Elena Ramírez
Background. Methylphenidate (MPH) is widely used in treating children with attention-deficit-hyperactivity disorder. Hepatotoxicity is a rare phenomenon; only few cases are described with no liver failure. Case. We report on the case of a 12-year-old boy who received MPH for attention-deficit-hyperactivity disorder. Two months later the patient presented with signs and symptoms of hepatitis and MPH was discontinued, showing progressive worsening and developing liver failure and a liver transplantation was required...
2015: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25654289/-rucam-scale-based-diagnosis-clinical-features-and-prognosis-of-140-cases-of-drug-induced-liver-injury
#18
Kunyan Hao, Yuecheng Yu, Changlun He, Maorong Wang, Shouming Wang, Xin Li
OBJECTIVE: To analyze the etiology, clinical features and prognosis of liver injuries caused by different drugs. METHODS: The types of suspected drugs related to liver injury, clinical manifestations, liver biochemical parameters, clinical outcomes and other associated data were retrospectively assessed for 140 patients with drug-induced liver injury (DILI). The Roussel Uclaf Causality Assessment Method (RUCAM) was used to assess the causality between drugs and liver injury...
December 2014: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/25506455/a-challenge-for-diagnosing-acute-liver-injury-with-concomitant-sequential-exposure-to-multiple-drugs-can-causality-assessment-scales-be-utilized-to-identify-the-offending-drug
#19
Roxanne Lim, Hassan Choudry, Kim Conner, Wikrom Karnsakul
Drug-induced hepatotoxicity most commonly manifests as an acute hepatitis syndrome and remains the leading cause of drug-induced death/mortality and the primary reason for withdrawal of drugs from the pharmaceutical market. We report a case of acute liver injury in a 12-year-old Hispanic boy, who received a series of five antibiotics (amoxicillin, ceftriaxone, vancomycin, ampicillin/sulbactam, and clindamycin) for cervical lymphadenitis/retropharyngeal cellulitis. Histopathology of the liver biopsy specimen revealed acute cholestatic hepatitis...
2014: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/25373453/hepatic-decompensation-likely-attributable-to-simeprevir-in-patients-with-advanced-cirrhosis
#20
Jonathan G Stine, Nicolas Intagliata, Neeral L Shah, Curtis K Argo, Stephen H Caldwell, James H Lewis, Patrick G Northup
BACKGROUND: Hyperbilirubinemia is a common side effect of protease inhibitors used to treat chronic hepatitis C (HCV), and most patients do not experience without clinically overt hepatotoxicity. The safety of second-wave protease inhibitors, including simeprevir, has not been well studied in patients with advanced cirrhosis. MATERIALS & METHODS: We report two cases of suspected drug-induced liver injury leading to hepatic decompensation in patients with advanced HCV cirrhosis treated with the combination of simeprevir and sofosbuvir on a compassionate basis...
April 2015: Digestive Diseases and Sciences
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