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https://www.readbyqxmd.com/read/28231461/tips-for-young-scientists-on-the-junior-faculty-independent-investigator-job-search
#1
Kelsey C Martin
Landing a job as an assistant professor or independent investigator in neuroscience in an academic institution or research institute depends on the accomplishments young scientists make during years of training as graduate students and postdoctoral fellows. This training prepares scientists for an array of exciting job opportunities, one of which is as a faculty member or independent investigator. My goal in this NeuroView is to provide tips about the job search for young scientists who have decided to enter the junior faculty/independent investigator job market...
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28230784/the-effects-of-moderate-whole-grain-consumption-on-fasting-glucose-and-lipids-gastrointestinal-symptoms-and-microbiota
#2
Danielle N Cooper, Mary E Kable, Maria L Marco, Angela De Leon, Bret Rust, Julita E Baker, William Horn, Dustin Burnett, Nancy L Keim
This study was designed to determine if providing wheat, corn, and rice as whole (WG) or refined grains (RG) under free-living conditions will change parameters of health over a six-week intervention in healthy, habitual non-WG consumers. Measurements of body composition, fecal microbiota, fasting blood glucose, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides were made at baseline and post intervention. Subjects were given adequate servings of either WG or RG products based on their caloric need and asked to keep records of grain consumption, bowel movements, and GI symptoms weekly...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28229539/appetite-self-regulation-environmental-and-policy-influences-on-eating-behaviors
#3
Marlene B Schwartz, David R Just, Jamie F Chriqui, Alice S Ammerman
OBJECTIVE: Appetite regulation is influenced by the environment, and the environment is shaped by food-related policies. This review summarizes the environment and policy research portion of an NIH Workshop (Bethesda, MD, 2015) titled "Self-Regulation of Appetite-It's Complicated." METHODS: In this paper, we begin by making the case for why policy is an important tool in efforts to improve nutrition, and we introduce an ecological framework that illustrates the multiple layers that influence what people eat...
March 2017: Obesity
https://www.readbyqxmd.com/read/28228088/aryl-heteroaryl-substituted-celecoxib-derivatives-as-cox-2-inhibitors-synthesis-anti-inflammatory-activity-and-molecular-docking-studies
#4
Golla Madhava, Katla Venkata Ramana, Saddala Madhu Sudhana, Devineni Subba Rao, Kuntrapakam Hema Kumar, Valluru Lokanatha, Asupatri Usha Rani, Chamarthi Naga Raju
BACKGROUND: Cyclooxygenase (COX-2) inhibitors have been developed to provide better anti-inflammatory and analgesic efficacy than those of traditional NSAIDs. Several compounds having selective COX-2 inhibitors such as SC-558, Celecoxib, Rofecoxib, Valdecoxib and Etoricoxib are marketed as new generation NSAIDs and block the production of prostaglandins (PGs) in inflammatory cells. New anti-inflammatory dynamic agents with improved potency and safety profile are still needed. OBJECTIVE: As a part of our continuation research work towards the synthesis of anti-inflammatory agents, the synthesis of N-substituted aryl/heteroaryl-pyrazole-1yl benzene sulfonamide (Celecoxib) derivatives, and evaluated their anti-inflammatory activity in both methods in vitro and in vivo, and molecular docking study on COX-2 enzyme will be discussed in this study...
February 20, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28228076/transdermal-drug-delivery-opportunities-and-challenges-for-controlled-delivery-of-therapeutic-agents-using-nanocarriers
#5
Balak Das Kurmi, Pawan Tekchandani, Rishi Paliwal, Shivani Rai Paliwal
BACKGROUND: Transdermal drug delivery represents an extremely attractive and innovative route across the skin owing to the possibility for achieving systemic effect of drugs. Present scenario demands a special focus on developing safe medicine with minimize toxic adverse effects related to most of the pharmacologically active agents. Transdermal drug delivery would be a focal paradigm which provides patient convenience, first-pass hepatic metabolism avoidance, local targeting and reduction in toxic effect related to various categories of drugs like, analgesics, anti-inflammatory, antibiotics, antiviral, anaesthetic, anticancer etc...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28228075/challenges-in-dermal-delivery-of-therapeutic-antimicrobial-protein-and-peptides
#6
Rohan Aminbhai Lalani, Ambikanandan Misra, Jitendra Amrutiya, Hinal Patel, Priyanka Bhatt, Vivek Patel
BACKGROUND: Protein and peptides in biological system form an important part of innate immune system and are being explored for potential use in various diseases as therapeutics. Importance of proteins and peptides as a new class of antimicrobial agents have boosted research in the field of biotechnology as potential alternative to antibiotic agents. OBJECTIVE: Protein and peptides antimicrobial as a therapeutics class are structurally diverse and exhibit potent activity against microbes by various mechanisms...
February 22, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28227018/using-constrained-information-entropy-to-detect-rare-adverse-drug-reactions-from-medical-forums
#7
Yi Zheng, Chaowang Lan, Hui Peng, Jinyan Li, Yi Zheng, Chaowang Lan, Hui Peng, Jinyan Li, Jinyan Li, Hui Peng, Chaowang Lan, Yi Zheng
Adverse drug reactions (ADRs) detection is critical to avoid malpractices yet challenging due to its uncertainty in pre-marketing review and the underreporting in post-marketing surveillance. To conquer this predicament, social media based ADRs detection methods have been proposed recently. However, existing researches are mostly co-occurrence based methods and face several issues, in particularly, leaving out the rare ADRs and unable to distinguish irrelevant ADRs. In this work, we introduce a constrained information entropy (CIE) method to solve these problems...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226963/design-and-characterization-of-a-torque-controllable-actuator-for-knee-assistance-during-sit-to-stand
#8
Max K Shepherd, Elliott J Rouse, Max K Shepherd, Elliott J Rouse, Elliott J Rouse, Max K Shepherd
Individuals with post-stroke hemiparesis often have difficulty standing out of a chair. One way to potentially improve sit-to-stand is to provide knee extension assistance using a powered knee exoskeleton. An exoskeleton providing unilateral, partial assistance during sit-to-stand would need to be torque-controllable. There are no knee exoskeletons on the market suitable for conducting experiments assisting stroke patients with sit-to-stand, so to enable such experiments a research device was developed. The purpose of this report is to present the design of a novel knee exoskeleton actuator that uses a fiberglass leaf spring in series to improve torque-controllability, and present a characterization of the actuator performance...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225447/environmental-market-factors-associated-with-electronic-health-record-adoption-among-cancer-hospitals
#9
Will L Tarver, Nir Menachemi
BACKGROUND: Although recent literature has explored the relationship between various environmental market characteristics and the adoption of electronic health records (EHRs) among general, acute care hospitals, no such research currently exists for specialty hospitals, including those providing cancer care. PURPOSE: The aim of the study was to examine the relationship between market characteristics and the adoption of EHRs among Commission on Cancer (CoC)-accredited hospitals...
February 22, 2017: Health Care Management Review
https://www.readbyqxmd.com/read/28224793/a-never-ending-story-of-per-and-polyfluoroalkyl-substances-pfass
#10
Zhanyun Wang, Jamie C DeWitt, Christopher P Higgins, Ian T Cousins
More than 3000 per- and polyfluoroalkyl substances (PFASs) are, or have been, on the global market, yet most research and regulation continues to focus on a limited selection of rather well-known long-chain PFASs, particularly perfluorooctanesulfonate (PFOS), perfluorooctanoic acid (PFOA) and their precursors. Continuing to overlook the vast majority of other PFASs is a major concern for society. We provide recommendations for how to proceed with research and cooperation to tackle the vast number of PFASs on the market and in the environment...
February 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28223995/synergistic-action-of-a-microbial-based-biostimulant-and-a-plant-derived-protein-hydrolysate-enhances-lettuce-tolerance-to-alkalinity-and-salinity
#11
Youssef Rouphael, Mariateresa Cardarelli, Paolo Bonini, Giuseppe Colla
In the coming years, farmers will have to deal with growing crops under suboptimal conditions dictated by global climate changes. The application of plant biostimulants such as beneficial microorganisms and plant-derived protein hydrolysates (PHs) may represent an interesting approach for increasing crop tolerance to alkalinity and salinity. The current research aimed at elucidating the agronomical, physiological, and biochemical effects as well as the changes in mineral composition of greenhouse lettuce (Lactuca sativa L...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28222849/considering-employee-needs-during-a-catastrophe-requires-innovative-recovery-plans-why-traditional-workplace-recovery-solutions-are-outdated
#12
Joe Sullivan
Mobile technology has changed the way we live and operate, with co-working, flexible spaces and home office solutions that offer us the freedom to work when and where we choose. However, when disaster strikes the workplace, people are often the last to be considered in the recovery process. This paper examines strategies for businesses and their employees to continue working after a disaster strikes. It explores the trends in the market, the benefits and drawbacks of different approaches and the attitudes of continuity experts and small business owners who have the responsibility to ensure that businesses, and people, continue to function, even when their main place of work is inaccessible...
January 1, 2017: Journal of Business Continuity & Emergency Planning
https://www.readbyqxmd.com/read/28222488/explaining-counterfeit-alcohol-purchases-in-russia
#13
Zoya Kotelnikova
BACKGROUND: Alcohol is a common target of counterfeiting in Russia. Counterfeit alcohol is defined here as the manufacture, distribution, unauthorized placement (forgery) of protected commodity trademarks, and infringement of the exclusive rights of the registered trademark holders of alcoholic beverages. It is often argued that the expansion of the counterfeit product market is due to the steady demand of economically disadvantaged people for low-priced goods. The situation becomes more complicated once deceptive and nondeceptive forms of counterfeiting are taken into account...
February 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28221988/prevalence-and-phylogenetic-characterization-of-escherichia-coli-and-hygiene-indicator-bacteria-isolated-from-leafy-green-produce-beef-and-pork-obtained-from-farmers-markets-in-pennsylvania
#14
Joshua A Scheinberg, Edward G Dudley, Jonathan Campbell, Beth Roberts, Michael DiMarzio, Chitrita DebRoy, Catherine N Cutter
The popularity of farmers' markets in the United States has led to over 8,400 farmers' markets being in operation in 2015. As farmers' markets have increased in size and complexity in the kinds of foods sold at these venues, so have the potential food safety risks. Since 2008, seven major foodborne illness outbreaks and two recalls associated with food products from farmers' markets have occurred, causing 80 known reported illnesses and one death. Various researchers also have observed vendors performing high-risk food safety retail behaviors, and others have identified microbiological hazards in foods sold at farmers' markets...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221966/annual-effective-dose-of-gamma-emitters-in-adults-and-children-for-some-types-of-rice-consumed-in-iraq
#15
Ali Abid Abojassim, Dahir Mohammad Dahir, Azhar S Alaboodi, Abbas H Abonasria
This work studies the activity concentration of natural radioactivity in 20 different types of rice, including imported rice and that produced locally. The rice samples were collected from markets and farms in Iraq, and then a natural radioactivity investigation was done in the environmental laboratory of the Kufa University, using gamma-ray spectrometer systems. The research focused on measuring the activity concentration of natural radioactivity ((238)U, (232)Th, and (40)K) to determine the level of the radium equivalent activity, internal hazard indices, and annual effective dose...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28220961/carbon-based-perovskite-solar-cells-without-hole-transport-materials-the-front-runner-to-the-market
#16
REVIEW
Haining Chen, Shihe Yang
Organometal trihalide perovskite solar cells (PSCs) have garnered recent interest in the scientific community. In the past few years, they have achieved power conversion efficiencies comparable to traditional commercial solar cells (e.g., crystalline Si, CuInGaSe and CdTe) due to their low-cost of production via solution-processed fabrication techniques. However, the stability of PSCs must be addressed before their commercialization is viable. Among various kinds of PSCs, carbon-based PSCs without hole transport materials (C-PSCs) seem to be the most promising for addressing the stability issue because carbon materials are stable, inert to ion migration (which originates from perovskite and metal electrodes), and inherently water-resistant...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220276/taxonomic-examination-of-longgu-fossilia-ossis-mastodi-dragon-bone-and-a-related-crude-drug-longchi-dens-draconis-dragon-tooth-from-japanese-and-chinese-crude-drug-markets
#17
Kazuki Oguri, Yuichiro Nishioka, Yoshitsugu Kobayashi, Kyoko Takahashi
Longgu ("dragon bone," Ryu-kotsu, Fossilia Ossis Mastodi, or Os Draconis) is the only fossil crude drug listed in the Japanese Pharmacopoeia. All longgu in the current Japanese market is imported from China, where its resources are being depleted. Therefore, effective countermeasures are urgently needed to prevent resource depletion. One possible solution is the development of a substitute made from bones of contemporary animals that are closely related to the original animal source of the current longgu. However, no research has been conducted on the original animal source of longgu, except for a report on the longgu specimens present in the Shosoin Repository...
February 20, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28219727/economic-botany-collections-a-source-of-material-evidence-for-exploring-historical-changes-in-chinese-medicinal-materials
#18
Eric Brand, Christine Leon, Mark Nesbitt, Ping Guo, Ran Huang, Hubiao Chen, Li Liang, Zhongzhen Zhao
ETHNOPHARMACOLOGICAL RELEVANCE: Many Chinese medicinal materials (CMMs) have changed over centuries of use, particularly in terms of their botanical identity and processing methods. In some cases, these changes have important implications for safety and efficacy in modern clinical practice. As most previous research has focused on clarifying the evolution of CMMs by analyzing traditional Chinese materia medica ("bencao") literature, assessments of historical collections are needed to validate these conclusions with material evidence...
February 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28219114/self-reported-youth-and-adult-exposure-to-alcohol-marketing-in-traditional-and-digital-media-results-of-a-pilot-survey
#19
David H Jernigan, Alisa Padon, Craig Ross, Dina Borzekowski
BACKGROUND: Alcohol marketing is known to be a significant risk factor for underage drinking. However, little is known about youth and adult exposure to alcohol advertising in digital and social media. This study piloted a comparative assessment of youth and adult recall of exposure to online marketing of alcohol. METHODS: From September to October 2013, a pilot survey of past 30-day exposure to alcohol advertising and promotional content in traditional and digital media was administered to a national sample of 1,192 youth (ages 13 to 20) and 1,124 adults (ages ≥21) using a prerecruited Internet panel maintained by GfK Custom Research...
February 20, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28215387/dissemination-of-technology-to-evaluate-healthy-food-incentive-programs
#20
Darcy A Freedman, Alan R Hunt, Katie Merritt, En-Jung Shon, Stephanie N Pike
INTRODUCTION: Federal policy supports increased implementation of monetary incentive interventions for chronic disease prevention among low-income populations. This study describes how a Prevention Research Center, working with a dissemination partner, developed and distributed technology to support nationwide implementation and evaluation of healthy food incentive programming focused on Supplemental Nutrition Assistance Program recipients. METHODS: FM Tracks, an iOS-based application and website, was developed to standardize evaluation methods for healthy food incentive program implementation at direct-to-consumer markets...
March 2017: American Journal of Preventive Medicine
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