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https://www.readbyqxmd.com/read/29774137/saudi-anti-human-cancer-plants-database-sacpd-a-collection-of-plants-with-anti-human-cancer-activities
#1
Ateeq Ahmed Al-Zahrani
Several anticancer drugs have been developed from natural products such as plants. Successful experiments in inhibiting the growth of human cancer cell lines using Saudi plants were published over the last three decades. Up to date, there is no Saudi anticancer plants database as a comprehensive source for the interesting data generated from these experiments. Therefore, there was a need for creating a database to collect, organize, search and retrieve such data. As a result, the current paper describes the generation of the Saudi anti-human cancer plants database (SACPD)...
January 30, 2018: Oncology Reviews
https://www.readbyqxmd.com/read/29773528/a-digital-app-to-aid-detection-monitoring-and-management-of-dyslexia-in-young-children-dimmand-protocol-for-a-digital-health-and-education-solution
#2
Mariam R Sood, Annet Toornstra, Martin I Sereno, Mark Boland, Daniele Filaretti, Anuj Sood
BACKGROUND: Dyslexia, a specific learning difficulty and a disability as defined in the Equality Act 2010, is a lifelong condition that affects a child from the start of education. Dyslexia is characterized by difficulties in language processing (reading, spelling, and writing) which do not correspond with the child's general intellectual abilities. Although dyslexia cannot be cured, there is a consensus that interventions are more effective and have greater impact the earlier they are administered...
May 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29773056/nanocrystals-technology-for-pharmaceutical-science
#3
Zhongyao Cheng, Yumei Lian, Zul Kamal, Xin Ma, Jianjun Chen, Xinbo Zhou, Jing Su, Mingfeng Qiu
BACKGROUND: Nanocrystals technology is a promising method for improving the dissolution rate and enhancing the bioavailability of poorly soluble drugs. In recent years, it has been developing rapidly and applied to drug research and engineering. Nanocrystal drugs can be formulated into various dosage forms. OBJECTIVE: This review mainly focused on the nanocrystals technology and its application in pharmaceutical science. Firstly, different preparation methods of nanocrystal technology and the characterization of nanocrystal drugs are briefly described...
May 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29772289/nose-to-brain-drug-delivery-an-update-on-clinical-challenges-and-progress-towards-approval-of-anti-alzheimer-drugs
#4
REVIEW
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
May 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29770325/linking-supply-chain-governance-and-biosecurity-in-the-context-of-hpai-control-in-western-java-a-value-chain-perspective
#5
Dikky Indrawan, Karl M Rich, Peter van Horne, Arief Daryanto, Henk Hogeveen
Despite extensive efforts to control the highly pathogenic avian influenza (HPAI), it remains endemic in Western Java, Indonesia. To understand the limited effectiveness of HPAI control measures, it is important to map the complex structure of the poultry sector. The governance of the poultry value chain in particular, could play a pivotal role, yet there is limited information on the different chain governance structures and their impacts on HPAI control. This article uses value chain analysis (VCA), focusing on an in-depth assessment of governance structures as well as transaction cost economics and quantitative estimates of the market power of different chain actors, to establish a theoretical framework to examine biosecurity and HPAI control in the Western Java poultry chain...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29770277/a-strategy-to-find-novel-candidate-anti-alzheimer-s-disease-drugs-by-constructing-interaction-networks-between-drug-targets-and-natural-compounds-in-medical-plants
#6
Bi-Wen Chen, Wen-Xing Li, Guang-Hui Wang, Gong-Hua Li, Jia-Qian Liu, Jun-Juan Zheng, Qian Wang, Hui-Juan Li, Shao-Xing Dai, Jing-Fei Huang
Background: Alzheimer' disease (AD) is an ultimately fatal degenerative brain disorder that has an increasingly large burden on health and social care systems. There are only five drugs for AD on the market, and no new effective medicines have been discovered for many years. Chinese medicinal plants have been used to treat diseases for thousands of years, and screening herbal remedies is a way to develop new drugs. Methods: We used molecular docking to screen 30,438 compounds from Traditional Chinese Medicine (TCM) against a comprehensive list of AD target proteins...
2018: PeerJ
https://www.readbyqxmd.com/read/29769135/health-inequalities-between-employed-and-unemployed-in-northern-sweden-a-decomposition-analysis-of-social-determinants-for-mental-health
#7
Anna Brydsten, Anne Hammarström, Miguel San Sebastian
BACKGROUND: Even though population health is strongly influenced by employment and working conditions, public health research has to a lesser extent explored the social determinants of health inequalities between people in different positions on the labour market, and whether these social determinants vary across the life course. This study analyses mental health inequalities between unemployed and employed in three age groups (youth, adulthood and mid-life), and identifies the extent to which social determinants explain the mental health gap between employed and unemployed in northern Sweden...
May 16, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29769080/a-complex-culturally-targeted-intervention-to-reduce-hispanic-disparities-in-living-kidney-donor-transplantation-an-effectiveness-implementation-hybrid-study-protocol
#8
Elisa J Gordon, Jungwha Lee, Raymond H Kang, Juan Carlos Caicedo, Jane L Holl, Daniela P Ladner, Michelle D Shumate
BACKGROUND: The shortage of organs for kidney transplantation for patients with end-stage renal disease (ESRD) is magnified in Hispanics/Latin Americans in the United States. Living donor kidney transplantation (LDKT) is the treatment of choice for ESRD. However, compared to their representation on the transplant waitlist, fewer Hispanics receive a LDKT than non-Hispanic whites. Barriers to LDKT for Hispanics include: lack of knowledge, cultural concerns, and language barriers. Few interventions have been designed to reduce LDKT disparities...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29769067/antioxidant-capacity-of-cinnamon-extract-for-palm-oil-stability
#9
Muhammad Zia Shahid, Hafiza Saima, Adeela Yasmin, Muhammad Tahir Nadeem, Muhammad Imran, Muhammad Afzaal
BACKGROUND: Spices and their bioactive components are more promising attractions for their inclusion in diet-based regimes to improve human health. These are sources of natural antioxidants and play an important role in the chemoprevention of diseases and aging. The aim of the current study was to explore the antioxidant potential of cinnamon; a widely used spice throughout the world. METHODS: The current research was aimed to investigate the antioxidant potential of cinnamon extract...
May 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29768712/innovation-at-the-intersection-of-clinical-trials-and-real-world-data-science-to-advance-patient-care
#10
REVIEW
Brandon Swift, Lokesh Jain, Craig White, Vasu Chandrasekaran, Aman Bhandari, Dyfrig A Hughes, Pravin R Jadhav
While efficacy and safety data collected from randomized clinical trials are the evidentiary standard for determining market authorization, this alone may no longer be sufficient to address the needs of key stakeholders (regulators, providers, and payers) and guarantee long-term success of pharmaceutical products. There is a heightened interest from stakeholders on understanding the use of real-world evidence (RWE) to substantiate benefit-risk assessment and support the value of a new drug. This review provides an overview of real-world data (RWD) and related advances in the regulatory framework, and discusses their impact on clinical research and development...
May 16, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29768576/recent-advances-and-perspectives-in-cancer-drug-design
#11
Luma G Magalhaes, Leonardo L G Ferreira, Adriano D Andricopulo
Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments...
May 14, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29766832/northstar-perspectives-for-actinium-225-production-at-commercial-scale
#12
James T Harvey
Actinium-225, and its daughter bismuth-213, have great promise in alpha immuno therapy (AIT) for treatment of various disease modalities. Unfortunately, current production levels of actinium-225 that are commercially available do not support broad use of either actinium-225 or bismuth-213 in development or use for disease treatment. Further, the current cost per millicurie is much too high to be sustainable long term in the market. Resolution of both supply and cost issues allows clinical research to proceed through clinical trials and potentially produce one or more effective therapies for cancer or infectious diseases that could benefit the public...
May 15, 2018: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29764957/examining-perceptions-about-iqos-heated-tobacco-product-consumer-studies-in-japan-and-switzerland
#13
Elizabeth C Hair, Morgane Bennett, Emily Sheen, Jennifer Cantrell, Jodie Briggs, Zoe Fenn, Jeffrey G Willett, Donna Vallone
OBJECTIVE: To examine consumer perceptions, attitudes and behaviours regarding the heated tobacco product, IQOS, as well as to document the product's marketing strategies to determine its potential for appealing to youth and young adults. METHOD: Truth Initiative, in collaboration with Flamingo, collected qualitative data via: (1) expert interviews, (2) semiotic analysis of IQOS packing and marketing materials, and (3) 12 focus groups with adults in Switzerland (ages 19-44 years; June 6-9, 2016) and Japan (ages 20-39 years; June 22-24, 2016) (n=68 for both groups)...
May 15, 2018: Tobacco Control
https://www.readbyqxmd.com/read/29764917/the-path-to-victory-a-beginner-s-guide-to-success-using-commercial-research-antibodies
#14
REVIEW
Simon L Goodman
Commercial research antibodies are crucial tools in modern cell biology and biochemistry. In the USA some $2 billion a year are spent on them, but many are apparently not fit-for-purpose, and this may contribute to the 'reproducibility crisis' in biological sciences. Inadequate antibody validation and characterization, lack of user awareness, and occasional incompetence amongst suppliers have had immense scientific and personal costs. In this Opinion, I suggest some paths to make the use of these vital tools more successful...
May 15, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29764795/mapping-of-crowdsourcing-in-health-systematic-review
#15
REVIEW
Perrine Créquit, Ghizlène Mansouri, Mehdi Benchoufi, Alexandre Vivot, Philippe Ravaud
BACKGROUND: Crowdsourcing involves obtaining ideas, needed services, or content by soliciting Web-based contributions from a crowd. The 4 types of crowdsourced tasks (problem solving, data processing, surveillance or monitoring, and surveying) can be applied in the 3 categories of health (promotion, research, and care). OBJECTIVE: This study aimed to map the different applications of crowdsourcing in health to assess the fields of health that are using crowdsourcing and the crowdsourced tasks used...
May 15, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29764767/a-systematic-review-of-mobile-produce-markets-facilitators-and-barriers-to-use-and-associations-with-reported-fruit-and-vegetable-intake
#16
Bi-Sek Hsiao, Lindiwe Sibeko, Lisa M Troy
BACKGROUND: Diet-related chronic diseases are a major public health burden. There is growing awareness that disparities in healthful food access contribute to disparities in health. Mobile produce markets (MPMs) have emerged as a strategy to improve fruit and vegetable access and consumption, particularly among low-income, minority, and other vulnerable populations (eg, older adults and children) in food desert neighborhoods. OBJECTIVE: This review examined research on MPMs in the United States and specifically aimed to assess the relationship between MPM use and fruit and/or vegetable intake, and facilitators and barriers related to MPM use within a social ecological framework...
May 12, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29764458/cone-beam-computed-tomography-in-implant-dentistry-recommendations-for-clinical-use
#17
Reinhilde Jacobs, Benjamin Salmon, Marina Codari, Bassam Hassan, Michael M Bornstein
BACKGROUND: In implant dentistry, three-dimensional (3D) imaging can be realised by dental cone beam computed tomography (CBCT), offering volumetric data on jaw bones and teeth with relatively low radiation doses and costs. The latter may explain why the market has been steadily growing since the first dental CBCT system appeared two decades ago. More than 85 different CBCT devices are currently available and this exponential growth has created a gap between scientific evidence and existing CBCT machines...
May 15, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29761160/measuring-and-preventing-alcohol-use-and-related-harm-among-young-people-in-asian-countries-a-thematic-review
#18
REVIEW
Heng Jiang, Xiaojun Xiang, Wei Hao, Robin Room, Xiaojie Zhang, Xuyi Wang
Background: The paper reviews alcohol consumption patterns and alcohol-related social and health issues among 15-29-year old young people in Asian countries, and discusses strategies for preventing and controlling alcohol use and related harms. Methods: We searched Google Scholar, PubMed, and Web of Science for reports, reviews and journal articles published in English between 1st Jan 1990 and 31st August 2016. Results: Forty-one reports, reviews and journal papers were identified and included in the final review...
2018: Global Health Research and Policy
https://www.readbyqxmd.com/read/29760332/dry-thermotropic-glycolipid-self-assembly-a-review
#19
Rauzah Hashim, N Idayu Zahid, T S Velayutham, Nurul Fadhilah Kamalul Aripin, Shigesaburo Ogawa, Akihiko Sugimura
Also recognized as carbohydrate liquid crystals, glycolipids are amphiphiles whose basic unit comprises of a sugar group attached to an alkyl chain. Glycolipids are amphitropic, which means these materials form liquid crystal self-assemblies when dry (thermotropic) as well as when dissolved in solvents (lyotropic/surfactants) such as water. Many glycolipids are also naturally derived since these can be found in cell membranes. Their membrane and surfactant functions are largely understood through their lyotropic properties...
May 15, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29758417/exploring-the-value-of-overseas-biodiversity-to-chinese-netizens-based-on-willingness-to-pay-for-the-african-elephants-protection
#20
Zhengzao Wang, Yazhen Gong, Xianqiang Mao
For a long time, Chinese people have been considered to be concerned only with commercial interests but not ecological systems and biodiversity conservation, even though their trade and investment footprints are globalizing rapidly. This study intended to reveal the non-market valuation on the non-use value of African elephant to Chinese people. Taking the ban of ivory trade as the background, in this study, Chinese netizens' willingness to pay for African elephant conservation was investigated using the contingent valuation method...
May 10, 2018: Science of the Total Environment
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