keyword
MENU ▼
Read by QxMD icon Read
search

MZF1

keyword
https://www.readbyqxmd.com/read/28720772/blockade-of-axl-signaling-ameliorates-hpv16e6-mediated-tumorigenecity-of-cervical-cancer
#1
Eun-Hee Lee, Kon-Young Ji, Eun-Mi Kim, Su-Man Kim, Hyeong-Woo Song, Ha-Rim Choi, Byung Yeoup Chung, Hyo Jin Choi, Hyoung-Woo Bai, Hyung-Sik Kang
Axl receptor tyrosine kinase is involved in the tumorigenesis and metastasis of many cancers. Axl expression was markedly higher in human papilloma virus type 16E6 (HPV16E6)-overexpressing HeLa (HE6F) cells and lower in HPV16E6-suppressing CaSki (CE6R) cells than in the controls. SiRNA-mediated knockdown of E6 expression led to increased phosphatase and tensin homolog (PTEN) phosphorylation at Ser380 and attenuated AKT phosphorylation. Expression of membrane-associated guanylate kinase inverted-2 (MAGI-2), an E6-induced degradation target, was induced in E6-siRNA-transfected cells...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28703907/tgf-%C3%AE-1-induced-ck17-enhances-cancer-stem-cell-like-properties-rather-than-emt-in-promoting-cervical-cancer-metastasis-via-the-erk1-2-mzf1-signaling-pathway
#2
Lanfang Wu, Lingfei Han, Chenfei Zhou, Wenfei Wei, Xiaojing Chen, Hongyan Yi, Xiangguang Wu, Xiangyang Bai, Suiqun Guo, Yanhong Yu, Li Liang, Wei Wang
Tumor metastasis remains a major obstacle for improving overall cancer survival in cervical cancer (CC), which may be due to the existence of tumor microenvironment-related cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT). The mechanism underlying these processes needs to be further elucidated. Here, we report that TGF-β1, one of the key microenvironmental stimuli, can enhance CSC characteristics, facilitate the EMT and induce CK17. Silencing CK17 expression attenuated CSC-like properties without affecting the EMT markers induced by TGF-β1, whereas forced over-expression of CK17 promoted lymphatic metastasis in vivo even without EMT inducement...
July 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28634046/tumor-antigen-prame-is-up-regulated-by-mzf1-in-cooperation-with-dna-hypomethylation-in-melanoma-cells
#3
Yong-Kyu Lee, Ui-Hyun Park, Eun-Joo Kim, Jin-Taek Hwang, Ji-Cheon Jeong, Soo-Jong Um
Elevated expression of preferentially expressed antigen in melanoma (PRAME) has been implicated in disease progression in a variety of cancers. However, the mechanisms underlying the transcriptional regulation of PRAME remain largely unexplored. Initially, we observed that PRAME was elevated in proportion to the malignant potential of melanoma cells. From the in silico prediction of PRAME gene structure, we identified the putative myeloid zinc finger 1 (MZF1) binding sites, which overlap with a CpG-rich region located in the first intron...
June 17, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28560409/construction-of-disease-specific-transcriptional-regulatory-networks-identifies-co-activation-of-four-gene-in-esophageal-squamous-cell-carcinoma
#4
Yu Zhao, Li Min, Changqin Xu, Linlin Shao, Shuilong Guo, Rui Cheng, Jie Xing, Shengtao Zhu, Shutian Zhang
Even though various molecules may serve as biomarkers, little is known concerning the mechanisms underlying the carcinogenesis of ESCC, particularly the transcriptional regulatory network. Thus, in the present study, paired ESCC and non-cancerous (NC) tissues were assayed by Affymetrix microarray assays. Passing Attributes between Networks for Data Assimilation (PANDA) was used to construct networks between transcription factors (TFs) and their targets. AnaPANDA program was applied to compare the regulatory networks...
May 30, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28478957/sirt6-regulated-nucleosomal-occupancy-affects-hexokinase-2-expression
#5
Piyushi Gupta, Touseef Sheikh, Ellora Sen
To understand the molecular association between inflammation and dysregulated metabolism in glioblastoma, the effect of IL-1β on Hexokinase 2 (HK2) expression was investigated. IL-1β induced HK2 expression was accompanied by heightened SIRT6 and MZF1 levels. IL-1β mediated overall decrease in chromatin compactness on HK2 promoter involved diminished nucleosomal occupancy around the most labile region bearing MZF1 sites. Importantly, SIRT6 and MZF1 served as negative regulators of HK2. Ectopic SIRT6 induced formation and recruitment of MZF1-SIRT6 complex to MZF1 site was concomitant with increased nucleosomal occupancy...
August 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28423538/gene-regulatory-pattern-analysis-reveals-essential-role-of-core-transcriptional-factors-activation-in-triple-negative-breast-cancer
#6
Li Min, Cheng Zhang, Like Qu, Jialiang Huang, Lan Jiang, Jiafei Liu, Luca Pinello, Guo-Cheng Yuan, Chengchao Shou
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype. Genome-scale molecular characteristics and regulatory mechanisms that distinguish TNBC from other subtypes remain incompletely characterized. RESULTS: By combining gene expression analysis and PANDA network, we defined three different TF regulatory patterns. A core TNBC-Specific TF Activation Driven Pattern (TNBCac) was specifically identified in TNBC by computational analysis...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28193206/inducing-goat-pluripotent-stem-cells-with-four-transcription-factor-mrnas-that-activate-endogenous-promoters
#7
Hao Chen, Qisheng Zuo, Yingjie Wang, Jiuzhou Song, Huilin Yang, Yani Zhang, Bichun Li
BACKGROUND: Traditional approaches for generating goat pluripotent stem cells (iPSCs) suffer from complexity and low preparation efficiency. Therefore, we tried to derive goat iPSCs with a new method by transfecting exogenous Oct4, Sox2, Klf4 and c-Myc mRNAs into goat embryonic fibroblasts (GEFs), and explore the mechanisms regarding the transcription regulation of the reprogramming factors in goat iPSCs induction. RESULTS: mRNAs of the four reprogramming factors were transfected into GEFs, and were localized in nucleus with approximately 90% transfection efficiency...
February 13, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28018905/the-mutational-landscape-of-the-oncogenic-mzf1-scan-domain-in-cancer
#8
Mads Nygaard, Thilde Terkelsen, André Vidas Olsen, Valentina Sora, Juan Salamanca Viloria, Fabio Rizza, Sanne Bergstrand-Poulsen, Miriam Di Marco, Mette Vistesen, Matteo Tiberti, Matteo Lambrughi, Marja Jäättelä, Tuula Kallunki, Elena Papaleo
SCAN domains in zinc-finger transcription factors are crucial mediators of protein-protein interactions. Up to 240 SCAN-domain encoding genes have been identified throughout the human genome. These include cancer-related genes, such as the myeloid zinc finger 1 (MZF1), an oncogenic transcription factor involved in the progression of many solid cancers. The mechanisms by which SCAN homo- and heterodimers assemble and how they alter the transcriptional activity of zinc-finger transcription factors in cancer and other diseases remain to be investigated...
2016: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/27922669/upregulation-of-smad4-by-mzf1-inhibits-migration-of-human-gastric-cancer-cells
#9
Jin-Hee Lee, Sung-Su Kim, Hun Seok Lee, Sungyoul Hong, Nirmal Rajasekaran, Li-Hui Wang, Joon-Seok Choi, Young Kee Shin
SMAD4 is a tumor suppressor that is frequently inactivated in many types of cancer. The role of abnormal expression of SMAD4 has been reported in developmental processes and the progression of various human cancers. The expression level of SMAD4 has been related to the survival rate in gastric cancer patients. However, the molecular mechanism underlying transcriptional regulation of SMAD4 remains largely unknown. In the present study, we characterized the promoter region of SMAD4 and identified myeloid zinc finger 1 (MZF1), as a putative transcription factor...
January 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27764784/dna-methylation-promotes-paired-box-2-expression-via-myeloid-zinc-finger-1-in-endometrial-cancer
#10
Nan Jia, Jieyu Wang, Qing Li, Xiang Tao, Kaikai Chang, Keqin Hua, Yinhua Yu, Kwong-Kwok Wong, Weiwei Feng
This work investigated the role of paired box 2 (PAX2) in endometrial cancer and its epigenetic regulation mechanism. Endometrial cancer tissues and cell lines exhibited increased PAX2 expression compared with hyperplasia, normal endometrium and endometrial epithelial cells. Knock-down of PAX2 resulted in reduced cell viability, invasion and migration, and PAX2 overexpression caused the opposite effects. Increased methylation of the PAX2 promoter was observed in both cancer tissues and cell lines and was positively correlated with PAX2 expression...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/27404893/otosclerosis-associated-with-a-de-novo-mutation-832g%C3%A2-%C3%A2-a-in-the-tgfb1-gene-promoter-causing-a-decreased-expression-level
#11
Saurabh Priyadarshi, Kirtal Hansdah, Chinmay Sundar Ray, Narayan Chandra Biswal, Puppala Venkat Ramchander
Otosclerosis (OTSC) is defined by abnormal bone remodeling in the otic capsule of middle ear which leads to conductive hearing loss. In our previous study, we have identified a de novo heterozygous mutation -832G > A in the promoter of TGFB1 in an otosclerosis patient. In the present study, we progressively screened this mutation in a cohort of 254 cases and 262 controls. The family members of the patient positive for -832G > A variation were also screened and found inheritance of this variation only to her daughter...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27259238/mirna-337-3p-inhibits-gastric-cancer-progression-through-repressing-myeloid-zinc-finger-1-facilitated-expression-of-matrix-metalloproteinase-14
#12
Liduan Zheng, Wanju Jiao, Hong Mei, Huajie Song, Dan Li, Xuan Xiang, Yajun Chen, Feng Yang, Huanhuan Li, Kai Huang, Qiangsong Tong
Matrix metalloproteinase 14 (MMP-14), a membrane-anchored MMP that promotes the tumorigenesis and aggressiveness, is highly expressed in gastric cancer. However, the transcriptional regulators of MMP-14 expression in gastric cancer still remain largely unknown. In this study, through mining computational algorithm programs and chromatin immunoprecipitation datasets, we identified adjacent binding sites of myeloid zinc finger 1 (MZF1) and miRNA-337-3p (miR-337-3p) within the MMP-14 promoter. We demonstrated that MZF1 directly bound to the MMP-14 promoter to facilitate its nascent transcription and expression in gastric cancer cell lines...
June 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/26697505/bioinformatic-evaluation-of-transcriptional-regulation-of-wnt-pathway-genes-with-reference-to-diabetic-nephropathy
#13
Gareth J McKay, David H Kavanagh, John K Crean, Alexander P Maxwell
OBJECTIVE: WNT/β-catenin pathway members have been implicated in interstitial fibrosis and glomerular sclerosis disease processes characteristic of diabetic nephropathy (DN), processes partly controlled by transcription factors (TFs) that bind to gene promoter regions attenuating regulation. We sought to identify predicted cis-acting transcription factor binding sites (TFBSs) overrepresented within WNT pathway members. METHODS: We assessed 62 TFBS motif frequencies from the JASPAR databases in 65 WNT pathway genes...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/26299976/application-of-human-haploid-cell-genetic-screening-model-in-identifying-the-genes-required-for-resistance-to-environmental-toxicants-chlorpyrifos-as-a-case-study
#14
Jinqiu Zhu, Amber Dubois, Yichen Ge, James A Olson, Xuefeng Ren
INTRODUCTION: High-throughput loss-of-function genetic screening tools in yeast or other model systems except in mammalian cells have been implemented to study human susceptibility to chemical toxicity. Here, we employed a newly developed human haploid cell (KBM7)-based mutagenic screening model (KBM7-mu cells) and examined its applicability in identifying genes whose absence allows cells to survive and proliferate in the presence of chemicals. METHODS: KBM7-mu cells were exposed to 200 μM Chlorpyrifos (CPF), a widely used organophosphate pesticide, a dose causing approximately 50% death of cells after 48h of treatment...
November 2015: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/26220195/allelic-mutations-in-noncoding-genomic-sequences-construct-novel-transcription-factor-binding-sites-that-promote-gene-overexpression
#15
Erming Tian, Magne Børset, Jeffrey R Sawyer, Gaute Brede, Thea K Våtsveen, Håkon Hov, Anders Waage, Bart Barlogie, John D Shaughnessy, Joshua Epstein, Anders Sundan
The growth and survival factor hepatocyte growth factor (HGF) is expressed at high levels in multiple myeloma (MM) cells. We report here that elevated HGF transcription in MM was traced to DNA mutations in the promoter alleles of HGF. Sequence analysis revealed a previously undiscovered single-nucleotide polymorphism (SNP) and crucial single-nucleotide variants (SNVs) in the promoters of myeloma cells that produce large amounts of HGF. The allele-specific mutations functionally reassembled wild-type sequences into the motifs that affiliate with endogenous transcription factors NFKB (nuclear factor kappa-B), MZF1 (myeloid zinc finger 1), and NRF-2 (nuclear factor erythroid 2-related factor 2)...
November 2015: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/26209503/transcriptional-regulation-of-the-vegf-gene-in-dependence-of-individual-genomic-variations
#16
REVIEW
Carmen S Metzger, Dimitrios Koutsimpelas, Juergen Brieger
Overexpression of the vascular endothelial growth factor (VEGF) gene has been associated with advanced stage and poor survival in several cancers. The majority of disease-associated VEGF-single nucleotide polymorphisms (SNPs) locate within regulatory regions. Therefore, an influence of SNPs located in the promoter/5'-untranslated region (5'UTR) on transcription factor binding (TFB) and gene expression seems feasible. We reviewed the literature investigating a potential connection of VEGF-SNPs and transcriptional regulation of the VEGF gene...
December 2015: Cytokine
https://www.readbyqxmd.com/read/25903835/role-and-regulation-of-myeloid-zinc-finger-protein-1-in-cancer
#17
REVIEW
Taka Eguchi, Thomas Prince, Barbara Wegiel, Stuart K Calderwood
Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors...
October 2015: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/25899830/myeloid-zinc-finger-1-mzf-1-regulates-expression-of-the-ccn2-ctgf-and-ccn3-nov-genes-in-the-hematopoietic-compartment
#18
Richard T Piszczatowski, Brian J Rafferty, Andre Rozado, James V Parziale, Nathan H Lents
Connective Tissue Growth Factor (CCN2/CTGF) and Nephroblastoma Overexpressed (CCN3/NOV) execute key functions within the hematopoietic compartment. Both are abundant in the bone marrow stroma, which is a niche for hematopoiesis and supports marrow function. Roles for 1,25-dihydroxyvitamin D3 (calcitriol) and all-trans retinoic acid in the bone marrow have also been elucidated. Interestingly, some of the annotated roles of these vitamins overlap with established functions of CCN2 and CCN3. Yet, no factor has been identified that unifies these observations...
November 2015: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25884514/the-transcription-factors-ik-1-and-mzf1-downregulate-igf-ir-expression-in-npm-alk%C3%A2-%C2%BA-t-cell-lymphoma
#19
Deeksha Vishwamitra, Choladda V Curry, Serhan Alkan, Yao-Hua Song, Gary E Gallick, Ahmed O Kaseb, Ping Shi, Hesham M Amin
BACKGROUND: The type I insulin-like growth factor receptor (IGF-IR) tyrosine kinase promotes the survival of an aggressive subtype of T-cell lymphoma by interacting with nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) oncogenic protein. NPM-ALK(+) T-cell lymphoma exhibits much higher levels of IGF-IR than normal human T lymphocytes. The mechanisms underlying increased expression of IGF-IR in this lymphoma are not known. We hypothesized that upregulation of IGF-IR could be attributed to previously unrecognized defects that inherently exist in the transcriptional machinery in NPM-ALK(+) T-cell lymphoma...
2015: Molecular Cancer
https://www.readbyqxmd.com/read/25877752/expression-of-myeloid-zinc-finger-1-and-the-correlation-to-clinical-aspects-of-oral-squamous-cell-carcinoma
#20
Chung-Po Ko, Li-Chiu Yang, Chih-Jung Chen, Kun-Tu Yeh, Shu-Hui Lin, Shun-Fa Yang, Mu-Kuan Chen, Chiao-Wen Lin
The myeloid zinc finger 1 (MZF1) is a zinc finger transcription factor which regulates myeloid differentiation and oncogenesis. However, little information is available concerning the MZF1 expression in oral squamous cell carcinoma (OSCC) and its correlation with patients' prognosis. We detected the expression of MZF1 in 274 patients with OSCC using tissue microarrays (TMAs) and evaluated the associations between nuclear MZF1 expression and the clinical parameters of OSCC patients. We found that nuclear MZF1 expression was present in 190/274 (69...
September 2015: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
keyword
keyword
119124
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"