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https://www.readbyqxmd.com/read/29146386/the-risk-of-symptomatic-knee-osteoarthritis-after-arthroscopic-meniscus-repair-vs-partial-meniscectomy-vs-the-general-population
#1
Fredrik Persson, Aleksandra Turkiewicz, Dan Bergkvist, Paul Neuman, Martin Englund
OBJECTIVE: To compare consultation rate for knee osteoarthritis (OA) after meniscus repair, arthroscopic partial meniscectomy (APM), and in general population, respectively. METHOD: We identified patients aged 16-45 years having had meniscus surgery due to traumatic meniscus tear in 1998-2010 in southern Sweden by a healthcare register. Patients were followed from surgery until a diagnosis of knee OA, relocation, death, or December 31(st), 2015. We studied the consultation rate for knee OA compared to the general population...
November 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29082539/efficient-%C3%A2-0-norm-feature-selection-based-on-augmented-and-penalized-minimization
#2
Xiang Li, Shanghong Xie, Donglin Zeng, Yuanjia Wang
Advances in high-throughput technologies in genomics and imaging yield unprecedentedly large numbers of prognostic biomarkers. To accommodate the scale of biomarkers and study their association with disease outcomes, penalized regression is often used to identify important biomarkers. The ideal variable selection procedure would search for the best subset of predictors, which is equivalent to imposing an ℓ0 -penalty on the regression coefficients. Since this optimization is a nondeterministic polynomial-time hard (NP-hard) problem that does not scale with number of biomarkers, alternative methods mostly place smooth penalties on the regression parameters, which lead to computationally feasible optimization problems...
October 30, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29034528/patients-with-a-new-variant-of-endemic-pemphigus-foliaceus-have-autoantibodies-against-arrector-pili-muscle-colocalizing-with-myzap-p0071-desmoplakins-1-and-2-and-arvcf
#3
A M Abreu-Velez, C A Valencia-Yepes, Y A Upegui-Zapata, E Upegui-Quiceno, N R Mesa-Herrera, J E Velazquez-Velez, M S Howard
BACKGROUND: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM. METHODS: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex and occupation, who were all from the endemic area, and tested these using direct immunofluorescence (DIF), confocal microscopy, immunohistochemistry and immunoblotting (IB)...
October 15, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29025772/impaired-hla-class-i-antigen-processing-and-presentation-as-a-mechanism-of-acquired-resistance-to-immune-checkpoint-inhibitors-in-lung-cancer
#4
Scott Gettinger, Jungmin Choi, Katherine Hastings, Anna Truini, Ila Datar, Ryan Sowell, Anna Wurtz, Weilai Dong, Guoping Cai, Mary Ann Melnick, Victor Y Du, Joseph Schlessinger, Sarah B Goldberg, Anne Chiang, Miguel F Sanmamed, Ignacio Melero, Jackeline Agorreta, Luis M Montuenga, Richard Lifton, Soldano Ferrone, Paula Kavathas, David L Rimm, Susan M Kaech, Kurt A Schalper, Roy S Herbst, Katerina Politi
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICIs) are poorly understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and presentation machinery (APM) components or interferon signaling play a role in acquired resistance to PD-1 or PD-L1 antagonistic antibodies. Recurrent mutations or copy number changes were not detected in our cohort. In one case, we found acquired homozygous loss of B2M that caused lack of cell surface HLA class I expression in the tumor and a matched patient-derived xenograft (PDX)...
October 12, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28993985/gastroesophageal-reflux-after-sleeve-gastrectomy-a-prospective-mechanistic-study
#5
Muriel Coupaye, Caroline Gorbatchef, Daniela Calabrese, Ouidad Sami, Simon Msika, Benoit Coffin, Séverine Ledoux
BACKGROUND: Evolution of gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) is controversial. Some authors report worsening or improvement of preoperative GERD, others the occurrence of de novo GERD between 5 and 69%. AIMS: The aims of this study are to evaluate the evolution of GERD after SG by ambulatory 24-h pH monitoring (APM) and to determine pre- and postoperative clinical and manometric factors associated with its evolution. METHODS: Between 2013 and 2015, 47 patients operated in our center performed APM before and 1 year (14...
October 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28983220/similar-cost-savings-of-bundled-payment-initiatives-applied-to-lower-extremity-total-joint-arthroplasty-can-be-achieved-applying-both-models-2-and-3
#6
Allyson Alfonso, Lorraine Hutzler, Bill Robb, Chad Beste, André Blom, Joseph Bosco
BACKGROUND: In an effort to control cost and increase value, Medicare is transitioning from fee-for-service to value-based alternative payment models (APMs). The Bundled Payments for Care Improvement (BPCI) initiative represents one such voluntary APM. BPCI offers four different bundling options: model 1 covers all Diagnosis Related Groups (DRGs) and Models 2-4 cover 48 clinical episodes, including 186 separate DRGs. QUESTIONS/PURPOSES: The purpose of this investigation is to analyze and compare the cost savings achieved by two different BPCI program participants, provider A and provider B, enrolled in different models of BPCI (Models 2 and 3) for lower extremity joint replacements (LEJRs)...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28980974/analytical-probabilistic-modeling-of-rbe-weighted-dose-for-ion-therapy
#7
Hans-Peter Wieser, Philipp Hennig, Niklas Wahl, Mark Bangert
Particle therapy is especially prone to uncertainties. This issue is usually being addressed with uncertainty quantification and minimization techniques based on scenario sampling. For proton therapy, however, it was recently shown that it is also possible to use closed-form computations based on Analytical Probabilistic Modeling (APM) for this purpose. APM yields unique features compared to sampling-based approaches motivating further research in this context. This paper demonstrates the application of APM for intensity-modulated carbon ion therapy to quantify the influence of setup and range uncertainties on the RBE-weighted dose...
October 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28963077/payment-and-care-for-hematopoietic-cell-transplantation-patients-toward-a-specialized-medical-home-for-complex-care-patients
#8
James L Gajewski, Mark B McClellan, Navneet S Majhail, Parameswaran N Hari, Christopher N Bredeson, Richard T Maziarz, Charles F LeMaistre, Michael C Lill, Stephanie H Farnia, Krishna V Komanduri, Michael J Boo
Patient-centered medical home models are fundamental to the advanced alternative payment models defined in the Medicare Access and Children's Health Insurance Plan Reauthorization Act (MACRA). The patient-centered medical home is a model of healthcare delivery supported by alternative payment mechanisms and designed to promote coordinated medical care that is simultaneously patient-centric and population-oriented. This transformative care model requires shifting reimbursement to include a per-patient payment intended to cover services not previously reimbursed such as disease management over time...
September 28, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28956027/the-impact-of-changes-in-medicare-s-physician-payment-system-on-critical-care
#9
Charles E Hobson, Azra Bihorac, Mehrnaz Hadian, Daniel L Herr, Thomas G Rainey, Frank B Cerra, Lena M Napolitano, John W Hoyt
In 2015 President Obama signed the Medicare Access and CHIP Reauthorization Act (MACRA) which repealed the Sustainable Growth Rate (SGR) mechanism for Medicare physician reimbursement and mandated that CMS develop alternative payment methodologies to "reward health care providers for giving better care not more just more care." MACRA makes 3 major changes to Medicare reimbursements: (1) it ends the SGR formula; (2) it establishes a new framework to reward physicians based on performance and health outcomes rather than volume; and (3) it aims to combine existing quality reporting programs into one streamlined system...
February 2017: Crit Connect
https://www.readbyqxmd.com/read/28955632/prokaryotic-diversity-and-biochemical-properties-in-aging-artificial-pit-mud-used-for-the-production-of-chinese-strong-flavor-liquor
#10
Zhongke Sun, Can Chen, Xiaoge Hou, Jie Zhang, Fengshou Tian, Chengwei Li
At present, artificial pit mud (APM) is widely used in Chinese liquor-making industry and plays a particular role in the production of Chinese strong flavor liquor (CSFL). However, APM frequently ages during fermentation, thus becoming unsuitable for sustainable use due to its low-quality. The reasons behind, and results of, APM aging during the production of CSFL are not yet understood. Sequencing the V4 region of the 16S rRNA gene shows that prokaryotic diversity is significantly decreased (Shannon's diversity index, P < 0...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28920658/value-based-health-care-how-to-succeed-in-a-bundled-care-apm
#11
Daniel T Engelman
No abstract text is available yet for this article.
March 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28918225/on-the-relationship-between-executive-functions-of-working-memory-and-components-derived-from-fluid-intelligence-measures
#12
Xuezhu Ren, Karl Schweizer, Tengfei Wang, Pei Chu, Qin Gong
The aim of the current study is to provide new insights into the relationship between executive functions and intelligence measures in considering the item-position effect observed in intelligence items. Raven's Advanced Progressive Matrices (APM) and Horn's LPS reasoning test were used to assess fluid intelligence which served as criterion in investigating the relationship between intelligence and executive functions. A battery of six experimental tasks measured the updating, shifting, and inhibition processes of executive functions...
October 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28916281/explaining-the-spatiotemporal-variation-of-fine-particle-number-concentrations-over-beijing-and-surrounding-areas-in-an-air-quality-model-with-aerosol-microphysics
#13
Xueshun Chen, Zifa Wang, Jie Li, Huansheng Chen, Min Hu, Wenyi Yang, Zhe Wang, Baozhu Ge, Dawei Wang
In this study, a three-dimensional air quality model with detailed aerosol microphysics (NAQPMS + APM) was applied to simulate the fine particle number size distribution and to explain the spatiotemporal variation of fine particle number concentrations in different size ranges over Beijing and surrounding areas in the haze season (Jan 15 to Feb 13 in 2006). Comparison between observations and the simulation indicates that the model is able to reproduce the main features of the particle number size distribution...
December 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28870403/high-antigen-processing-machinery-component-expression-in-langerhans-cells-from-melanoma-patients-sentinel-lymph-nodes
#14
Maria Raffaella Romoli, Paola Di Gennaro, Gianni Gerlini, Serena Sestini, Paola Brandani, Soldano Ferrone, Lorenzo Borgognoni
Langerhans cells (LCs) from melanoma patients sentinel lymph nodes (SLN) are poor T cell activators mostly due to an immature immunophenotype. However Antigen Presenting Machinery (APM) role is unknown. We investigated HLA-class I APM components (Delta, LMP-7/10, TAP-1, Calnexin, Tapasin, β2-microglobulin and HLA-A,B,C) in LCs from healthy donors skin and melanoma patients SLN. APM component levels were low in immature epidermal LCs and significantly increased after maturation (p<0.05); their levels were significantly high in SLN LCs (p<0...
October 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28835410/injury-profile-suffered-by-targets-of-antipersonnel-improvised-explosive-devices-prospective-cohort-study
#15
Shane Smith, Melissa Devine, Joseph Taddeo, Vivian Charles McAlister
OBJECTIVE: To describe pattern 1 injuries caused by the antipersonnel improvised explosive device (AP-IED) in comparison to those previously described for antipersonnel mines (APM). DESIGN: Prospective cohort study of 100 consecutive pedestrian victims of an AP-IED, with traumatic amputation without regard for gender, nationality or military status. SETTING: Multinational Medical Unit at Kandahar Air Field, Afghanistan. PARTICIPANTS: One hundred consecutive patients, all male, 6-44 years old...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28815175/platelet-rich-plasma-an-elixir-for-treatment-of-alopecia-personal-experience-on-117-patients-with-review-of-literature
#16
REVIEW
Suruchi Garg, Shweta Manchanda
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28811980/erap1-overexpression-in-hpv-induced-malignancies-a-possible-novel-immune-evasion-mechanism
#17
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K Grabowska, Angelika B Riemer
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV(+) tumor samples. Therefore in this study, systematic expression analysis of the APM was performed on the mRNA and protein level in a comprehensive collection of HPV16(+) cell lines...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28810518/ameliorative-effects-of-artemisia-pallens-in-a-murine-model-of-ovalbumin-induced-allergic-asthma-via-modulation-of-biochemical-perturbations
#18
Anwesha A Mukherjee, Amit D Kandhare, Supada R Rojatkar, Subhash L Bodhankar
INTRODUCTION: Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential. OBJECTIVE: To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats. MATERIALS AND METHOD: AHR was induced in male Sprague-Dawley rats (180-200g) by intraperitoneal (i...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28774199/physical-activity-patterns-and-clusters-in-1001-patients-with-copd
#19
Rafael Mesquita, Gabriele Spina, Fabio Pitta, David Donaire-Gonzalez, Brenda M Deering, Mehul S Patel, Katy E Mitchell, Jennifer Alison, Arnoldus Jr van Gestel, Stefanie Zogg, Philippe Gagnon, Beatriz Abascal-Bolado, Barbara Vagaggini, Judith Garcia-Aymerich, Sue C Jenkins, Elisabeth Apm Romme, Samantha Sc Kon, Paul S Albert, Benjamin Waschki, Dinesh Shrikrishna, Sally J Singh, Nicholas S Hopkinson, David Miedinger, Roberto P Benzo, François Maltais, Pierluigi Paggiaro, Zoe J McKeough, Michael I Polkey, Kylie Hill, William D-C Man, Christian F Clarenbach, Nidia A Hernandes, Daniela Savi, Sally Wootton, Karina C Furlanetto, Li W Cindy Ng, Anouk W Vaes, Christine Jenkins, Peter R Eastwood, Diana Jarreta, Anne Kirsten, Dina Brooks, David R Hillman, Thaís Sant'Anna, Kenneth Meijer, Selina Dürr, Erica Pa Rutten, Malcolm Kohler, Vanessa S Probst, Ruth Tal-Singer, Esther Garcia Gil, Albertus C den Brinker, Jörg D Leuppi, Peter Ma Calverley, Frank Wjm Smeenk, Richard W Costello, Marco Gramm, Roger Goldstein, Miriam Tj Groenen, Helgo Magnussen, Emiel Fm Wouters, Richard L ZuWallack, Oliver Amft, Henrik Watz, Martijn A Spruit
We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed...
August 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28760665/metritis-vaccination-in-holstein-dairy-heifers-using-a-herd-specific-multivalent-vaccine-effects-on-uterine-health-and-fertility-in-first-lactation
#20
M Freick, A Kunze, O Passarge, J Weber, S Geidel
In cattle, acute puerperal metritis (APM) compromises animal welfare and has an economic impact to the farmer because of the detrimental effects on reproductive performance, milk production, and survivability. The aim of this randomized clinical study was to investigate the effects of a prepartum immunization using a herd-specific multivalent vaccine on incidence of APM, prevalence of clinical endometritis (CE), and selected measures of reproductive performance in primiparous Holstein cows. Pregnant nulliparous cows (230±4days of gestation) assigned to the vaccinated group (VG; n=142) received subcutaneously 5...
July 22, 2017: Animal Reproduction Science
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