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https://www.readbyqxmd.com/read/29772984/pain-upon-inserting-a-peripheral-intravenous-catheter-size-does-not-matter
#1
Fredericus Hj van Loon, Lisette Apm Puijn, Wesly H van Aarle, Angelique Tm Dierick-van Daele, Arthur Ra Bouwman
BACKGROUND: Approximately 1.2 billion peripheral intravenous catheters are inserted across the world annually. It is known that intravenous cannulation may be a painful procedure, which affects cognitive abilities by increasing anxiety and discomfort. AIM: We hypothesized that inserting a smaller sized peripheral intravenous catheter has a lower level of pain sensation compared to a larger sized catheter. METHODS: This observational, cross-sectional study was conducted between May and October 2016, in which surgical patients, aged 18 years or older, were eligible to participate...
May 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29770517/validity-and-generalizability-of-findings-of-randomized-controlled-trials-on-arthroscopic-partial-meniscectomy-of-the-knee
#2
REVIEW
Antti Malmivaara
BACKGROUND: The validity and generalizability of evidence from trials on arthroscopic partial meniscectomy (APM) for a ruptured meniscus of the knee has been debated in scientific journals. OBJECTIVE: To assess the validity and generalizability of evidence for trials on effectiveness of APM by a novel Benchmarking method; and to compare this assessment with established assessment methods; and to make an overall assessment of the current evidence on validity and generalizability of findings...
May 16, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29768009/use-of-dual-ligand-modification-in-kupffer-cell-targeted-liposomes-to-examine-the-contribution-of-kupffer-cells-to-accelerated-blood-clearance-abc-phenomenon
#3
Chaoyang Lai, Cong Li, Xiang Luo, Mengyang Liu, Xinrong Liu, Ling Hu, Le Kang, Qiujun Qiu, Yihui Deng, Yanzhi Song
The "accelerated blood clearance (ABC) phenomenon" is known to be involved in the adaptive immune system. Regretfully, the relationship between the ABC phenomenon and innate immune system, especially with respect to Kupffer cells (KCs) has been largely unexplored. In this study, the contribution of KCs to ABC was examined using the 4-aminophenyl-α-D-mannopyranoside (APM) lipid derivative DSPE-PEG2000-APM (DPM) and the 4-aminophenyl-β-L-fucopyranoside (APF) lipid derivative DSPE-PEG2000-APF (DPF) as ligands for mannose/fucose receptors on KCs, which were synthesized and modified on the surface of liposomes...
May 16, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29743214/advancing-primary-care-through-alternative-payment-models-lessons-from-the-united-states-canada
#4
Andrew Bazemore, Robert L Phillips, Richard Glazier, Joshua Tepper
The United States and Canada share high costs, poor health system performance, and challenges to the transformation of primary care, in part due to the limitations of their fee-for-service payment models. Rapidly advancing alternative payment models (APMs) in both countries promise better support for the essential tasks of primary care. These include interdisciplinary teams, care coordination, self-management support, and ongoing communication. This article reviews learnings from a 2017 binational symposium of 150 experts in policy and research that included a discussion of ongoing APM experiments in the United States and Canada...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29731622/chronic-obstructive-pulmonary-disease-severity-and-its-association-with-obstructive-sleep-apnea-syndrome-impact-on-cardiac-autonomic-modulation-and-functional-capacity
#5
Katiany Thays Lopes Zangrando, Renata Trimer, Luiz Carlos Soares de Carvalho, Guilherme Peixoto Tinoco Arêas, Flávia Cristina Rossi Caruso, Ramona Cabiddu, Meliza Goi Roscani, Fabíola Paula Galhardo Rizzatti, Audrey Borghi-Silva
Background: The study was conducted to determine the impact of chronic obstructive pulmonary disease (COPD) in association with obstructive sleep apnea syndrome (OSAS) on cardiac autonomic control and functional capacity. Subjects and methods: The study was a cross-sectional prospective controlled clinical study. Heart rate variability indices of 24 COPD (n = 12) and COPD+OSAS (n = 12) patients were evaluated and compared by electrocardiographic recordings acquired during rest, active postural maneuver (APM), respiratory sinus arrhythmia maneuver (RSA-m), and the 6-minute walk test (6MWT)...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29723872/knee-osteoarthritis-after-arthroscopic-partial-meniscectomy-prevalence-and-progression-of-radiographic-changes-after-5-to-12-years-compared-with-contralateral-knee
#6
Umile Giuseppe Longo, Mauro Ciuffreda, Vincenzo Candela, Giacomo Rizzello, Valerio D'Andrea, Nicholas Mannering, Alessandra Berton, Giuseppe Salvatore, Vincenzo Denaro
The purpose of this study was to study the clinical and radiographic changes in the knee after arthroscopic partial meniscectomy (APM) at a long-term follow-up compared with the contralateral knee. We assessed 57 patients (38 males and 19 females) with pre- and postoperative weight-bearing radiography with a follow-up ranging from 5.1 to 12.1 years (mean: 8.1) to analyze prevalence and progression of knee osteoarthritis (OA) after APM. We stratified patients according to body mass index (BMI), type of lesion (degenerative vs...
May 3, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29713932/crowdsourced-versus-expert-evaluations-of-the-vesico-urethral-anastomosis-in-the-robotic-radical-prostatectomy-is-one-superior-at-discriminating-differences-in-automated-performance-metrics
#7
Paul J Oh, Jian Chen, David Hatcher, Hooman Djaladat, Andrew J Hung
Crowdsourcing from the general population is an efficient, inexpensive method of surgical performance evaluation. In this study, we compared the discriminatory ability of experts and crowdsourced evaluators (the Crowd) to detect differences in robotic automated performance metrics (APMs). APMs (instrument motion tracking and events data directly from the robot system) of anterior vesico-urethral anastomoses (VUAs) of robotic radical prostatectomies were captured by the dVLogger (Intuitive Surgical). Crowdsourced evaluators and four expert surgeons evaluated video footage using the Global Evaluative Assessment of Robotic Skills (GEARS) (individual domains and total score)...
April 30, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29709440/the-2018-ishlt-apm-ast-iccac-stsw-recommendations-for-the-psychosocial-evaluation-of-adult-cardiothoracic-transplant-candidates-and-candidates-for-long-term-mechanical-circulatory-support
#8
EDITORIAL
Mary Amanda Dew, Andrea F DiMartini, Fabienne Dobbels, Kathleen L Grady, Sheila G Jowsey-Gregoire, Annemarie Kaan, Kay Kendall, Quincy-Robyn Young, Susan E Abbey, Zeeshan Butt, Catherine C Crone, Sabina De Geest, Christina T Doligalski, Christiane Kugler, Laurie McDonald, Linda Ohler, Liz Painter, Michael G Petty, Desiree Robson, Thomas Schlöglhofer, Terry D Schneekloth, Jonathan P Singer, Patrick J Smith, Heike Spaderna, Jeffrey J Teuteberg, Roger D Yusen, Paula C Zimbrean
The psychosocial evaluation is well-recognized as an important component of the multifaceted assessment process to determine candidacy for heart transplantation, lung transplantation, and long-term mechanical circulatory support (MCS). However, there is no consensus-based set of recommendations for either the full range of psychosocial domains to be assessed during the evaluation, or the set of processes and procedures to be used to conduct the evaluation, report its findings, and monitor patients' receipt of and response to interventions for any problems identified...
April 27, 2018: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29625843/role-of-genetic-variations-on-mhc-class-i-antigen-processing-genes-in-human-cancer-and-viral-mediated-diseases
#9
Valerio D'Alicandro, Paolo Romania, Ombretta Melaiu, Doriana Fruci
Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell surface to eliminate transformed and virally infected cells expressing peptides derived from abnormal proteins. The generation of antigenic peptides and their loading on MHC class I molecules is a multistep process involving different molecules that constitute the so-called antigen processing and presentation machinery (APM). To avoid immune-mediated elimination, human tumors and pathogens have adopted different strategies including loss of MHC class I expression and dysregulation of APM genes and proteins...
April 3, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29621113/a-repeated-power-training-enhances-fatigue-resistance-while-reducing-intraset-fluctuations
#10
Oliver Gonzalo-Skok, Julio Tous-Fajardo, Gerard Moras, José Luis Arjol-Serrano, Alberto Mendez-Villanueva
Oliver, GS, Julio, TF, Moras, G, José Luis, AS, and Alberto, MV. A repeated power training enhances fatigue resistance while reducing intraset fluctuations. J Strength Cond Res XX(X): 000-000, 2018-The present study analyzed the effects of adding an upper-body repeated power ability (RPA) training to habitual strength training sessions. Twenty young elite male basketball players were randomly allocated into a control group (CON, n = 10) or repeated power group (RPG, n = 10) and evaluated by 1 repetition maximum (1RM), incremental load, and RPA tests in the bench press exercise before and after a 7-week period and a 4-week cessation period...
April 4, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29614770/development-and-on-field-testing-of-low-cost-portable-system-for-monitoring-pm2-5-concentrations
#11
Konstantinos N Genikomsakis, Nikolaos-Fivos Galatoulas, Panagiotis I Dallas, Luis Miguel Candanedo Ibarra, Dimitris Margaritis, Christos S Ioakimidis
Recent developments in the field of low-cost sensors enable the design and implementation of compact, inexpensive and portable sensing units for air pollution monitoring with fine-detailed spatial and temporal resolution, in order to support applications of wider interest in the area of intelligent transportation systems (ITS). In this context, the present work advances the concept of developing a low-cost portable air pollution monitoring system (APMS) for measuring the concentrations of particulate matter (PM), in particular fine particles with a diameter of 2...
April 1, 2018: Sensors
https://www.readbyqxmd.com/read/29607580/effectiveness-of-antenatal-perineal-massage-in-reducing-perineal-trauma-and-post-partum-morbidities-a-randomized-controlled-trial
#12
Emmanuel Onyebuchi Ugwu, Eric Sunday Iferikigwe, Samuel Nnamdi Obi, George Uchenna Eleje, Benjamin Chukwuma Ozumba
AIM: The study aimed to evaluate the effectiveness of antenatal perineal massage (APM) in reducing perineal trauma and post-partum morbidities. METHODS: A randomized controlled trial of 108 primigravidae at the University of Nigeria Teaching Hospital, Enugu, Nigeria, was conducted from January 2013 to May 2014. The intervention group received APM, while the control group did not receive APM. RESULTS: Women who received APM were significantly more likely to have an intact perineum after childbirth [27/53 (50...
April 2, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29571352/artificial-polymer-materials-debris-characteristics-along-the-moroccan-mediterranean-coast
#13
F Maziane, D Nachite, G Anfuso
A monitoring program was carried out in autumn 2015 along the Mediterranean coast of Morocco, at sites including urban, village and remote/rural beaches. Artificial Polymer Materials (APM) represented 70.64% of all collected items and included plastic (16 categories), foamed plastic (3) and other APM materials (2). Plastic items represented the dominant debris with 5356 items, i.e. 94.53% of all APM debris, foamed plastics presented 191 items (i.e. 3.37%) and other APM summed 119 items, i.e. 2.1% of all APM...
March 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29562524/revolution-of-alzheimer-precision-neurology-passageway-of-systems-biology-and-neurophysiology
#14
Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L Black, Arun L W Bokde, René S Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A Chiesa, Olivier Colliot, Cristina-Maria Coman, Bruno Dubois, Andrea Duggento, Stanley Durrleman, Maria-Teresa Ferretti, Nathalie George, Remy Genthon, Marie-Odile Habert, Karl Herholz, Yosef Koronyo, Maya Koronyo-Hamaoui, Foudil Lamari, Todd Langevin, Stéphane Lehéricy, Jean Lorenceau, Christian Neri, Robert Nisticò, Francis Nyasse-Messene, Craig Ritchie, Simone Rossi, Emiliano Santarnecchi, Olaf Sporns, Steven R Verdooner, Andrea Vergallo, Nicolas Villain, Erfan Younesi, Francesco Garaci, Simone Lista
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems dysfunction within distinct molecular, cellular, and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in different diseases and subgroups at different stages of pathophysiological progression. This translational research path is paralleled by an "omics"-based, hypothesis-free, exploratory research pathway, which will collect multimodal data from progressing asymptomatic, preclinical, and clinical neurodegenerative disease (ND) populations, within the wide continuous biological and clinical spectrum of ND, applying high-throughput and high-content technologies combined with powerful computational and statistical modeling tools, aimed at identifying novel dysfunctional systems and predictive marker signatures associated with ND...
March 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29558214/preliminary-assessment-of-a-novel-14-day-electrocardiographic-adhesive-patch-monitor-in-dogs
#15
Jonathan Lichtenberger, Kathryn M Meurs, Etienne Côté
Cardiac arrhythmias often are transient and might not be detected using conventional electrocardiographic (ECG) techniques. The adhesive patch monitor (APM) is a single-lead, lightweight, up to 14-day continuous ambulatory ECG monitor. This study aimed to prospectively assess its usability in four boxer dogs considered either to be healthy or to have arrhythmogenic right ventricular cardiomyopathy. Optimal recording was obtained by placing the APM on the left side of the animal's thorax, at the fifth intercostal space, slightly dorsal to the costochondral junction, and oriented either vertically or parallel to the long axis of the heart...
March 20, 2018: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/29553283/improving-quality-of-care-in-oncology-through-healthcare-payment-reform
#16
Lonnie Wen, Christine Divers, Melissa Lingohr-Smith, Jay Lin, Scott Ramsey
OBJECTIVES: To provide an overview of alternative payment models (APMs) and describe how leading national organizations involved with oncology care and payment are linking quality improvement initiatives and payment reform. STUDY DESIGN: Literature review. METHODS: For this review, we summarized the literature on APMs and their goals of improving healthcare quality while jointly controlling the cost of care. We described the types of APMs that have been examined in the real-world setting, specifically in the area of oncology, and how they have affected the quality of oncology care...
March 1, 2018: American Journal of Managed Care
https://www.readbyqxmd.com/read/29513636/home-dental-bleaching-monitored-with-microelectronic-sensors-to-record-the-wearing-times-of-an-acetate-tray-bleaching-product
#17
C C Pavani, D Sundfeld, T C Schott, Apm Bertoz, R Bigliazzi, R H Sundfeld
The present case study quantifies the clinical wearing time of an acetate tray/bleaching product during home dental bleaching. The patient was instructed to use a 10% carbamide peroxide gel for 6-8 hours each day for 20 days. The wearing time of the tray was measured by a microsensor from TheraMon microelectronic system (Sales Agency Gschladt, Hargelsberg, Austria) completely embedded in the tray so that the clinician would be informed as to the precise time the tray was placed in the mouth. Evaluation of the daily printout during dental bleaching demonstrated that the patient did not correctly follow the clinician's instructions as to the wearing time of the tray...
March 7, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29487978/defective-hla-class-i-antigen-processing-machinery-in-cancer
#18
Lei Cai, Theodoros Michelakos, Teppei Yamada, Song Fan, Xinhui Wang, Joseph H Schwab, Cristina R Ferrone, Soldano Ferrone
Malignant transformation of cells is frequently associated with defective HLA class I antigen processing machinery (APM) component expression. This abnormality may have functional relevance, since it may have a negative impact on tumor cell recognition by cognate T cells. Furthermore, HLA class I APM abnormalities appear to have clinical significance, since they are associated with poor prognosis in several malignant diseases and may play a role in the resistance to immune checkpoint inhibitor-based immunotherapy...
February 27, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29483985/advanced-pretibial-melanoma-apm-clinicians-behaviour-as-triggering-factor
#19
Georgi Tchernev, Ivan Pidakev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Georgi Konstantinov Maximov, Ilia Lozev
BACKGROUND: Pigmented lesions represent a broad spectrum of clinical conditions, both benign and malignant. The precise diagnosis is often a challenge, while the clinical diagnostic criteria could be misleading, as a result of the frequently atypical presentation of otherwise completely benign in nature lesions. The variety of therapeutic options for benign pigmented lesions including shave curettage, local laser destruction, electrocoagulation removal could sound enticingly both for the physician and patient, but they destroy the possibility for histological examination and provide a deceptively feeling of calm, that the problem is solved...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29476722/mir-51-regulates-gabaergic-synapses-by-targeting-rab-gef-glo-4-and-lysosomal-trafficking-related-glo-ap-3-pathway-in-caenorhabditis-elegans
#20
Shuai Zhang, Zhibin Fan, Ping Qiao, Yinsuo Zhao, Yanan Wang, Da Jiang, Xiangming Wang, Xiaojuan Zhu, Yu Zhang, Baiqu Huang, Jun Lu, Xiaoxue Li
A deficit of GABA (γ-aminobutyric acid) transmission will lead to epilepsy and other cognitive disorders. Recent evidence has shown that neuronal miRNAs affect various synapses, including GABAergic synapses. However, the miRNAs that control GABAergic synapses remain not fully understood. Here, we identified miR-51, a member of Caenorhabditis elegans miR-99/100 family, as a key regulator of GABAergic synapses. Loss of mir-51 increased PTZ (Pentylenetetrazole) and aldicarb hypersensitivities, and decreased the number of GABAergic synapses and abundance of GABAA receptors...
April 1, 2018: Developmental Biology
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