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https://www.readbyqxmd.com/read/28920658/value-based-health-care-how-to-succeed-in-a-bundled-care-apm
#1
Daniel T Engelman
No abstract text is available yet for this article.
March 2017: Bulletin of the American College of Surgeons
https://www.readbyqxmd.com/read/28918225/on-the-relationship-between-executive-functions-of-working-memory-and-components-derived-from-fluid-intelligence-measures
#2
Xuezhu Ren, Karl Schweizer, Tengfei Wang, Pei Chu, Qin Gong
The aim of the current study is to provide new insights into the relationship between executive functions and intelligence measures in considering the item-position effect observed in intelligence items. Raven's Advanced Progressive Matrices (APM) and Horn's LPS reasoning test were used to assess fluid intelligence which served as criterion in investigating the relationship between intelligence and executive functions. A battery of six experimental tasks measured the updating, shifting, and inhibition processes of executive functions...
September 14, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28916281/explaining-the-spatiotemporal-variation-of-fine-particle-number-concentrations-over-beijing-and-surrounding-areas-in-an-air-quality-model-with-aerosol-microphysics
#3
Xueshun Chen, Zifa Wang, Jie Li, Huansheng Chen, Min Hu, Wenyi Yang, Zhe Wang, Baozhu Ge, Dawei Wang
In this study, a three-dimensional air quality model with detailed aerosol microphysics (NAQPMS + APM) was applied to simulate the fine particle number size distribution and to explain the spatiotemporal variation of fine particle number concentrations in different size ranges over Beijing and surrounding areas in the haze season (Jan 15 to Feb 13 in 2006). Comparison between observations and the simulation indicates that the model is able to reproduce the main features of the particle number size distribution...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28870403/high-antigen-processing-machinery-component-expression-in-langerhans-cells-from-melanoma-patients-sentinel-lymph-nodes
#4
Maria Raffaella Romoli, Paola Di Gennaro, Gianni Gerlini, Serena Sestini, Paola Brandani, Soldano Ferrone, Lorenzo Borgognoni
Langerhans cells (LCs) from melanoma patients sentinel lymph nodes (SLN) are poor T cell activators mostly due to an immature immunophenotype. However Antigen Presenting Machinery (APM) role is unknown. We investigated HLA-class I APM components (Delta, LMP-7/10, TAP-1, Calnexin, Tapasin, β2-microglobulin and HLA-A,B,C) in LCs from healthy donors skin and melanoma patients SLN. APM component levels were low in immature epidermal LCs and significantly increased after maturation (p<0.05); their levels were significantly high in SLN LCs (p<0...
August 30, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28835410/injury-profile-suffered-by-targets-of-antipersonnel-improvised-explosive-devices-prospective-cohort-study
#5
Shane Smith, Melissa Devine, Joseph Taddeo, Vivian Charles McAlister
OBJECTIVE: To describe pattern 1 injuries caused by the antipersonnel improvised explosive device (AP-IED) in comparison to those previously described for antipersonnel mines (APM). DESIGN: Prospective cohort study of 100 consecutive pedestrian victims of an AP-IED, with traumatic amputation without regard for gender, nationality or military status. SETTING: Multinational Medical Unit at Kandahar Air Field, Afghanistan. PARTICIPANTS: One hundred consecutive patients, all male, 6-44 years old...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28815175/platelet-rich-plasma-an-elixir-for-treatment-of-alopecia-personal-experience-on-117-patients-with-review-of-literature
#6
REVIEW
Suruchi Garg, Shweta Manchanda
Platelet-rich plasma (PRP) has emerged as a new treatment modality in regenerative plastic surgery and dermatology. PRP is a simple, cost-effective and feasible treatment option with high patient satisfaction for hair loss and can be regarded as a valuable adjuvant treatment modality for androgenic alopecia and other types of non-scarring alopecias. Authors have proposed a hair model termed "Golden anchorage with 'molecular locking' of ectodermal and mesenchymal components for survival and integrity of hair follicle (HF)" in this article...
2017: Stem Cell Investigation
https://www.readbyqxmd.com/read/28811980/erap1-overexpression-in-hpv-induced-malignancies-a-possible-novel-immune-evasion-mechanism
#7
Alina Steinbach, Jan Winter, Miriam Reuschenbach, Renata Blatnik, Alexandra Klevenz, Miriam Bertrand, Stephanie Hoppe, Magnus von Knebel Doeberitz, Agnieszka K Grabowska, Angelika B Riemer
Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV(+) tumor samples. Therefore in this study, systematic expression analysis of the APM was performed on the mRNA and protein level in a comprehensive collection of HPV16(+) cell lines...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28810518/ameliorative-effects-of-artemisia-pallens-in-a-murine-model-of-ovalbumin-induced-allergic-asthma-via-modulation-of-biochemical-perturbations
#8
Anwesha A Mukherjee, Amit D Kandhare, Supada R Rojatkar, Subhash L Bodhankar
INTRODUCTION: Asthma is a chronic, heterogeneous airway disorder characterized by airway inflammatory and remodeling. Artemisia pallens has been reported to possess antioxidant, anti-inflammatory and Anti-allergic potential. OBJECTIVE: To evaluate the anti-asthmatic effects of methanolic extract of Artemisia pallens (APME) against ovalbumin (OVA)-induced airway hyperresponsiveness (AHR) in rats. MATERIALS AND METHOD: AHR was induced in male Sprague-Dawley rats (180-200g) by intraperitoneal (i...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28774199/physical-activity-patterns-and-clusters-in-1001-patients-with-copd
#9
Rafael Mesquita, Gabriele Spina, Fabio Pitta, David Donaire-Gonzalez, Brenda M Deering, Mehul S Patel, Katy E Mitchell, Jennifer Alison, Arnoldus Jr van Gestel, Stefanie Zogg, Philippe Gagnon, Beatriz Abascal-Bolado, Barbara Vagaggini, Judith Garcia-Aymerich, Sue C Jenkins, Elisabeth Apm Romme, Samantha Sc Kon, Paul S Albert, Benjamin Waschki, Dinesh Shrikrishna, Sally J Singh, Nicholas S Hopkinson, David Miedinger, Roberto P Benzo, François Maltais, Pierluigi Paggiaro, Zoe J McKeough, Michael I Polkey, Kylie Hill, William D-C Man, Christian F Clarenbach, Nidia A Hernandes, Daniela Savi, Sally Wootton, Karina C Furlanetto, Li W Cindy Ng, Anouk W Vaes, Christine Jenkins, Peter R Eastwood, Diana Jarreta, Anne Kirsten, Dina Brooks, David R Hillman, Thaís Sant'Anna, Kenneth Meijer, Selina Dürr, Erica Pa Rutten, Malcolm Kohler, Vanessa S Probst, Ruth Tal-Singer, Esther Garcia Gil, Albertus C den Brinker, Jörg D Leuppi, Peter Ma Calverley, Frank Wjm Smeenk, Richard W Costello, Marco Gramm, Roger Goldstein, Miriam Tj Groenen, Helgo Magnussen, Emiel Fm Wouters, Richard L ZuWallack, Oliver Amft, Henrik Watz, Martijn A Spruit
We described physical activity measures and hourly patterns in patients with chronic obstructive pulmonary disease (COPD) after stratification for generic and COPD-specific characteristics and, based on multiple physical activity measures, we identified clusters of patients. In total, 1001 patients with COPD (65% men; age, 67 years; forced expiratory volume in the first second [FEV1], 49% predicted) were studied cross-sectionally. Demographics, anthropometrics, lung function and clinical data were assessed...
August 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28760665/metritis-vaccination-in-holstein-dairy-heifers-using-a-herd-specific-multivalent-vaccine-effects-on-uterine-health-and-fertility-in-first-lactation
#10
M Freick, A Kunze, O Passarge, J Weber, S Geidel
In cattle, acute puerperal metritis (APM) compromises animal welfare and has an economic impact to the farmer because of the detrimental effects on reproductive performance, milk production, and survivability. The aim of this randomized clinical study was to investigate the effects of a prepartum immunization using a herd-specific multivalent vaccine on incidence of APM, prevalence of clinical endometritis (CE), and selected measures of reproductive performance in primiparous Holstein cows. Pregnant nulliparous cows (230±4days of gestation) assigned to the vaccinated group (VG; n=142) received subcutaneously 5...
July 22, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28732276/sampling-and-single-particle-analysis-for-the-chemical-characterisation-of-fine-atmospheric-particulates-a-review
#11
REVIEW
Michele Elmes, Massimo Gasparon
To better understand the potential environmental and human health impacts of fine airborne particulate matter (APM), detailed physical and chemical characterisation is required. The only means to accurately distinguish between the multiple compositions in APM is by single particle analysis. A variety of methods and instruments are available, which range from filter-based sample collection for off-line laboratory analysis to on-line instruments that detect the airborne particles and generate size distribution and chemical data in real time...
July 18, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28724788/multiparametric-immune-profiling-in-hpv-oral-squamous-cell-cancer
#12
Zipei Feng, Daniel Bethmann, Matthias Kappler, Carmen Ballesteros-Merino, Alexander Eckert, R Bryan Bell, Allen Cheng, Tuan Bui, Rom Leidner, Walter J Urba, Kent Johnson, Clifford Hoyt, Carlo B Bifulco, Juergen Bukur, Claudia Wickenhauser, Barbara Seliger, Bernard A Fox
Evaluation of T lymphocyte frequency provides prognostic information for patients with oral squamous cell cancer (OSCC). However, the effect of simultaneously evaluating T cell frequency and assessing suppressive elements and defects in antigen-processing machinery (APM) has not been clarified. Simultaneous characterization of CD3+, CD8+, FoxP3+, CD163+, and PD-L1+ cells using multispectral imaging was performed on sections from 119 patients with HPV- OSCC. Expression of β2-microglobulin, MHC class I heavy chain, and large multifunctional peptidase 10 was quantified, and all data were correlated with patient outcome...
July 20, 2017: JCI Insight
https://www.readbyqxmd.com/read/28698804/the-knee-meniscus-management-of-traumatic-tears-and-degenerative-lesions
#13
Philippe Beaufils, Roland Becker, Sebastian Kopf, Ollivier Matthieu, Nicolas Pujol
Meniscectomy is one of the most popular orthopaedic procedures, but long-term results are not entirely satisfactory and the concept of meniscal preservation has therefore progressed over the years. However, the meniscectomy rate remains too high even though robust scientific publications indicate the value of meniscal repair or non-removal in traumatic tears and non-operative treatment rather than meniscectomy in degenerative meniscal lesionsIn traumatic tears, the first-line choice is repair or non-removal...
May 2017: EFORT open reviews
https://www.readbyqxmd.com/read/28690302/a-rapid-dialysis-method-for-analysis-of-artificial-sweeteners-in-foods-2nd-report
#14
Shoichi Tahara, Sumiyo Yamamoto, Yukiko Yamajima, Hiroyuki Miyakawa, Yoko Uematsu, Kimio Monma
Following the previous report, a rapid dialysis method was developed for the extraction and purification of four artificial sweeteners, namely, sodium saccharide (Sa), acesulfame potassium (AK), aspartame (APM), and dulcin (Du), which are present in various foods. The method was evaluated by the addition of 0.02 g/kg of these sweeteners to a cookie sample, in the same manner as in the previous report. Revisions from the previous method were: reduction of the total dialysis volume from 200 to 100 mL, change of tube length from 55 to 50 cm, change of dialysate from 0...
2017: Shokuhin Eiseigaku Zasshi. Journal of the Food Hygienic Society of Japan
https://www.readbyqxmd.com/read/28680742/modulation-of-mhc-class-i-surface-expression-in-b16f10-melanoma-cells-by-methylseleninic-acid
#15
Claudia Lennicke, Jette Rahn, Jürgen Bukur, Falko Hochgräfe, Ludger A Wessjohann, Rudolf Lichtenfels, Barbara Seliger
The essential trace element selenium (Se) might play a role in cancer prevention as well as for cancer therapy. Its metabolite methylselenol is able to kill cells through distinct mechanisms including induction of reactive oxygen species, DNA damage and apoptosis. Since methylselenol affects innate immune responses by modulating the expression of NKG2D ligands, the aim of this study was to determine whether the methylselenol generating compound methylseleninic acid (MSA) influences the expression of the MHC class I surface antigens and growth properties thereby reverting immune escape...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28678120/patient-outcomes-after-observation-versus-debridement-of-unstable-chondral-lesions-during-partial-meniscectomy-the-chondral-lesions-and-meniscus-procedures-champ-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Leslie J Bisson, Melissa A Kluczynski, William M Wind, Marc S Fineberg, Geoffrey A Bernas, Michael A Rauh, John M Marzo, Zehua Zhou, Jiwei Zhao
BACKGROUND: It is unknown whether unstable chondral lesions observed during arthroscopic partial meniscectomy (APM) require treatment. We examined differences at 1 year with respect to knee pain and other outcomes between patients who had debridement (CL-Deb) and those who had observation (CL-noDeb) of unstable chondral lesions encountered during APM. METHODS: Patients who were ≥30 years old and undergoing APM were randomized to receive debridement (CL-Deb group; n = 98) or observation (CL-noDeb; n = 92) of unstable Outerbridge grade-II, III, or IV chondral lesions...
July 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28665174/inappropriate-use-of-arthroscopic-meniscal-surgery-in-degenerative-knee-disease
#17
Leander L S Muheim, Oliver Senn, Mathias Früh, Oliver Reich, Thomas Rosemann, Stefan M Neuner-Jehle
Background and purpose - Current evidence suggests that arthroscopic knee surgery has no added benefit compared with non-surgical management in degenerative meniscal disease. Yet in many countries, arthroscopic partial meniscectomy (APM) remains among the most frequently performed surgeries. This study quantifies and characterizes the dynamics of the current use of knee arthroscopies in Switzerland in a distinctively non-traumatic patient group. Methods - We assessed a non-accident insurance plan of a major Swiss health insurance company for surgery rates of APM, arthroscopic debridement and lavage in patients over the age of 40, comparing the years 2012 and 2015...
October 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28655789/acquired-immune-resistance-follows-complete-tumor-regression-without-loss-of-target-antigens-or-ifn%C3%AE-signaling
#18
Marco Donia, Katja Harbst, Marit van Buuren, Pia Kvistborg, Mattias F Lindberg, Rikke Andersen, Manja Idorn, Shamaila Munir Ahmad, Eva Ellebæk, Anja Mueller, Paolo Fagone, Ferdinando Nicoletti, Massimo Libra, Martin Lauss, Sine Reker Hadrup, Henrik Schmidt, Mads Hald Andersen, Per Thor Straten, Jonas A Nilsson, Ton N Schumacher, Barbara Seliger, Göran Jönsson, Inge Marie Svane
Cancer immunotherapy can result in durable tumor regressions in some patients. However, patients who initially respond often experience tumor progression. Here, we report mechanistic evidence of tumoral immune escape in an exemplary clinical case: a patient with metastatic melanoma who developed disease recurrence following an initial, unequivocal radiologic complete regression after T-cell-based immunotherapy. Functional cytotoxic T-cell responses, including responses to one mutant neoantigen, were amplified effectively with therapy and generated durable immunologic memory...
June 27, 2017: Cancer Research
https://www.readbyqxmd.com/read/28649976/efficiency-of-analytical-and-sampling-based-uncertainty-propagation-in-intensity-modulated-proton-therapy
#19
N Wahl, P Hennig, H P Wieser, M Bangert
The sensitivity of intensity-modulated proton therapy (IMPT) treatment plans to uncertainties can be quantified and mitigated with robust/min-max and stochastic/probabilistic treatment analysis and optimization techniques. Those methods usually rely on sparse random, importance, or worst-case sampling. Inevitably, this imposes a trade-off between computational speed and accuracy of the uncertainty propagation. Here, we investigate analytical probabilistic modeling (APM) as an alternative for uncertainty propagation and minimization in IMPT that does not rely on scenario sampling...
June 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28641274/an-efficient-multiple-variants-coordination-framework-for-differential-evolution
#20
Sheng Xin Zhang, Shao Yong Zheng, Li Ming Zheng
Differential evolution (DE) is recognized as a simple but powerful algorithm in the family of evolutionary algorithms. Over the past two decades, many advanced DE variants with significantly improved performance have been proposed. However, the variants may only achieve the best performance on a certain type of functions. Moreover, a specific optimizer may not always be suitable for the whole optimization process. To overcome these weaknesses, this paper proposes a multiple variants coordination (MVC) framework with two mechanisms, namely, the multiple variants adaptive selecting mechanism and the multiple variants adaptive solutions preserving mechanisms (MV-APM)...
September 2017: IEEE Transactions on Cybernetics
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