keyword
MENU ▼
Read by QxMD icon Read
search

Apm

keyword
https://www.readbyqxmd.com/read/29348866/protein-methyltransferases-and-demethylases-dictate-cd8-t-cell-exclusion-in-squamous-cell-carcinoma-of-the-head-and-neck
#1
Theodore Vougiouklakis, Riyue Bao, Yusuke Nakamura, Vassiliki Saloura
A subset of patients with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) benefit from pembrolizumab and nivolumab, but the majority of patients do not probably due to lack of activated cytotoxic CD8+ T-cells in their tumor tissues. Herein, we aim to investigate whether specific protein methyltransferases (PMTs) and demethylases (PDMTs) could play any roles in the CD8+ T-cell exclusion process in HPV-negative SCCHN. RNA sequencing data from the TCGA database were interrogated for HPV-negative SCCHN patients using a 10-gene chemokine signature that classifies SCCHN tissues into CD8+ T-cell inflamed and non-CD8+ T-cell inflamed phenotypes...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29347402/stable-lattice-boltzmann-model-for-maxwell-equations-in-media
#2
A Hauser, J L Verhey
The present work shows a method for stable simulations via the lattice Boltzmann (LB) model for electromagnetic waves (EM) transiting homogeneous media. LB models for such media were already presented in the literature, but they suffer from numerical instability when the media transitions are sharp. We use one of these models in the limit of pure vacuum derived from Liu and Yan [Appl. Math. MODEL: 38, 1710 (2014)AMMODL0307-904X10.1016/j.apm.2013.09.009] and apply an extension that treats the effects of polarization and magnetization separately...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29341793/platelet-transfusion-does-not-improve-outcomes-in-patients-with-brain-injury-on-antiplatelet-therapy
#3
Jeremy L Holzmacher, Cassandra Reynolds, Mayur Patel, Patrick Maluso, Seth Holland, Nathaniel Gamsky, Henry Moore, Elizabeth Acquista, Matthew Carrick, Richard Amdur, Heather Hancock, Michael Metzler, Julie Dunn, Babak Sarani
INTRODUCTION: Platelet dysfunction following traumatic brain injury (TBI) is associated with worse outcomes. The efficacy of platelet transfusion to reverse antiplatelet medication (APM) remains unknown. Thrombelastography platelet mapping (TEG-PM) assesses platelet function. We hypothesize that platelet transfusion can reverse the effects of APM but does not improve outcomes following TBI. METHODS: An observational study at six US trauma centres was performed. Adult patients on APM with CT evident TBI after blunt injury were enrolled...
January 17, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29310642/urban-particulate-matter-pm-suppresses-airway-antibacterial-defence
#4
Xiaoyan Chen, Jinguo Liu, Jian Zhou, Jian Wang, Cuicui Chen, Yuanlin Song, Jue Pan
BACKGROUND: Epidemiological studies have shown that urban particulate matter (PM) increases the risk of respiratory infection. However, the underlying mechanisms are poorly understood. PM has been postulated to suppress the activation of airway epithelial innate defence in response to infection. METHODS: The effects of PM on antibacterial defence were studied using an in vitro infection model. The levels of antimicrobial peptides were measured using RT-PCR and ELISA...
January 8, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29281798/how-does-the-presence-of-unstable-chondral-lesions-affect-patient-outcomes-after-partial-meniscectomy-the-champ-randomized-controlled-trial
#5
Leslie J Bisson, Melissa A Kluczynski, William M Wind, Marc S Fineberg, Geoffrey A Bernas, Michael A Rauh, John M Marzo, Zehua Zhou, Jiwei Zhao
BACKGROUND: Chondral lesions are commonly encountered during arthroscopic partial meniscectomy (APM); however, it is unknown how these lesions affect postoperative outcomes. PURPOSE: The authors compared postoperative outcomes among patients with and without unstable chondral lesions 1 year after APM. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: The authors conducted a secondary analysis of data from the ChAMP (Chondral Lesions and Meniscus Procedures) randomized controlled trial...
December 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29275484/growth-extracellular-alkaline-phosphatase-activity-and-kinetic-characteristic-responses-of-the-bloom-forming-toxic-cyanobacterium-microcystis-aeruginosa-to-atmospheric-particulate-matter-pm2-5-pm2-5-10-and-pm-10
#6
Ziran Xu, Shoubing Wang, Yuanan Wang, Jie Zhang
Atmospheric particulate matter (APM), commonly seen and widely excited in environment, appears great enough to influence the biochemical processes in aquatic microorganisms and phytoplankton. Understanding the response of cyanobacteria to various factors is fundamental for eutrophication control. To clarify the response of cyanobacteria to APM, the effects of PM2.5, PM2.5-10, and PM>10 on Microcystis aeruginosa were researched. Variabilities in cell density, chlorophyll a, soluble protein, malondialdehyde, extracellular activity, and kinetic parameters of alkaline phosphatase were evaluated by lab-cultured experiments...
December 23, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29258882/transcriptome-comparison-of-meniscus-from-patients-with-and-without-osteoarthritis
#7
Robert H Brophy, Bo Zhang, Lei Cai, Rick W Wright, Linda J Sandell, Muhammad Farooq Rai
OBJECTIVE: To assess the impact of osteoarthritis (OA) on the meniscus by comparing transcripts and biological processes in the meniscus between patients with and without OA. DESIGN: RNA microarrays were used to identify transcripts differentially expressed (DE) in meniscus obtained from 12 OA and 12 non-OA patients. The non-OA specimens were obtained at the time of arthroscopic partial meniscectomy (APM). Real-time PCR was performed on selected transcripts. Biological processes and gene-networking was examined computationally...
December 16, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29232674/speech-and-language-pathologists-voice-use-in-working-environments-a-field-study-using-ambulatory-phonation-monitoring
#8
Francesco Mozzanica, Alessandro Selvaggio, Daniela Ginocchio, Nicole Pizzorni, Letizia Scarponi, Antonio Schindler
OBJECTIVE: The aim of this study was to evaluate the speech and language pathologists' (SLPs) voice production during a typical working day. PATIENTS AND METHODS: A total of 28 SLPs, all females, were enrolled. According to the type of treated disease, the cohort of SLPs was divided into 4 groups (7 SLPs focused on the rehabilitation of dysphagic adult clients; 7 SLPs focused on the rehabilitation of deaf children; 7 SLPs focused on the rehabilitation of dysphonic adult clients; and 7 SLPs focused on the rehabilitation of aphasic adult clients)...
December 12, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/29232073/medicare-program-cancellation-of-advancing-care-coordination-through-episode-payment-and-cardiac-rehabilitation-incentive-payment-models-changes-to-comprehensive-care-for-joint-replacement-payment-model-extreme-and-uncontrollable-circumstances-policy-for-the
#9
(no author information available yet)
This final rule cancels the Episode Payment Models (EPMs) and Cardiac Rehabilitation (CR) Incentive Payment Model and rescinds the regulations governing these models. It also implements certain revisions to the Comprehensive Care for Joint Replacement (CJR) model, including: Giving certain hospitals selected for participation in the CJR model a one-time option to choose whether to continue their participation in the model; technical refinements and clarifications for certain payment, reconciliation and quality provisions; and a change to increase the pool of eligible clinicians that qualify as affiliated practitioners under the Advanced Alternative Payment Model (Advanced APM) track...
December 1, 2017: Federal Register
https://www.readbyqxmd.com/read/29232069/medicare-program-cy-2018-updates-to-the-quality-payment-program-and-quality-payment-program-extreme-and-uncontrollable-circumstance-policy-for-the-transition-year-final-rule-with-comment-period-and-interim-final-rule-with-comment-period
#10
(no author information available yet)
The Medicare Access and CHIP Reauthorization Act of 2015 (MACRA) established the Quality Payment Program for eligible clinicians. Under the Quality Payment Program, eligible clinicians can participate via one of two tracks: Advanced Alternative Payment Models (APMs); or the Merit-based Incentive Payment System (MIPS). We began implementing the Quality Payment Program through rulemaking for calendar year (CY) 2017. This final rule with comment period provides updates for the second and future years of the Quality Payment Program...
November 16, 2017: Federal Register
https://www.readbyqxmd.com/read/29183885/can-we-predict-the-clinical-outcome-of-arthroscopic-partial-meniscectomy-a-systematic-review
#11
REVIEW
Susanne M Eijgenraam, Max Reijman, Sita M A Bierma-Zeinstra, Daan T van Yperen, Duncan E Meuffels
NHS-PROSPERO REGISTRATION NUMBER: 42016048592 OBJECTIVE: In order to make a more evidence-based selection of patients who would benefit the most from arthroscopic partial meniscectomy (APM), knowledge of prognostic factors is essential. We conducted a systematic review of predictors for the clinical outcome following APM. DESIGN: Systematic review DATA SOURCES: Medline, Embase, Cochrane Central Register, Web of Science, SPORTDiscus, PubMed Publisher, Google Scholar INCLUSION CRITERIA: Report an association between factor(s) and clinical outcome; validated questionnaire; follow-up >1 year...
November 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29153524/minimum-inhibitory-concentrations-of-frequently-used-antibiotics-against-escherichia-coli-and-trueperella-pyogenes-isolated-from-uteri-of-postpartum-dairy-cows
#12
A Pohl, A Lübke-Becker, W Heuwieser
The objective of this study was to determine minimum inhibitory concentrations (MIC) of frequently used antimicrobials for Escherichia coli and Trueperella pyogenes isolated from postpartum bovine uteri of cows with acute puerperal metritis (APM, n = 67), cows suspected to have APM (n = 37), and healthy cows (n = 37) and to evaluate possible differences in MIC according to clinical signs. Cows with APM had reddish-brown, fetid vaginal discharge and rectal temperature (RT) ≥39.5°C within 21 d in milk; cows suspected to have APM had either reddish-brown, fetid vaginal discharge or RT ≥39...
November 15, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29146386/the-risk-of-symptomatic-knee-osteoarthritis-after-arthroscopic-meniscus-repair-vs-partial-meniscectomy-vs-the-general-population
#13
Fredrik Persson, Aleksandra Turkiewicz, Dan Bergkvist, Paul Neuman, Martin Englund
OBJECTIVE: To compare consultation rate for knee osteoarthritis (OA) after meniscus repair, arthroscopic partial meniscectomy (APM), and in general population, respectively. METHOD: We identified patients aged 16-45 years having had meniscus surgery due to traumatic meniscus tear in 1998-2010 in southern Sweden by a healthcare register. Patients were followed from surgery until a diagnosis of knee OA, relocation, death, or December 31(st), 2015. We studied the consultation rate for knee OA compared to the general population...
November 13, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29082539/efficient-%C3%A2-0-norm-feature-selection-based-on-augmented-and-penalized-minimization
#14
Xiang Li, Shanghong Xie, Donglin Zeng, Yuanjia Wang
Advances in high-throughput technologies in genomics and imaging yield unprecedentedly large numbers of prognostic biomarkers. To accommodate the scale of biomarkers and study their association with disease outcomes, penalized regression is often used to identify important biomarkers. The ideal variable selection procedure would search for the best subset of predictors, which is equivalent to imposing an ℓ0 -penalty on the regression coefficients. Since this optimization is a nondeterministic polynomial-time hard (NP-hard) problem that does not scale with number of biomarkers, alternative methods mostly place smooth penalties on the regression parameters, which lead to computationally feasible optimization problems...
October 30, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29034528/patients-with-a-new-variant-of-endemic-pemphigus-foliaceus-have-autoantibodies-against-arrector-pili-muscle-colocalizing-with-myzap-p0071-desmoplakins-1-and-2-and-arvcf
#15
A M Abreu-Velez, C A Valencia-Yepes, Y A Upegui-Zapata, E Upegui-Quiceno, N R Mesa-Herrera, J E Velazquez-Velez, M S Howard
BACKGROUND: We identified a new variant of endemic pemphigus foliaceus in El Bagre, Colombia, South America, which we term El Bagre-EPF, and observed reactivity to arrector pili muscle (APM), thus we tested for autoimmunity to APM. METHODS: We took skin biopsies from 30 patients with El Bagre-EPF and 30 healthy controls (HCs) matched by age, sex and occupation, who were all from the endemic area, and tested these using direct immunofluorescence (DIF), confocal microscopy, immunohistochemistry and immunoblotting (IB)...
October 15, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29025772/impaired-hla-class-i-antigen-processing-and-presentation-as-a-mechanism-of-acquired-resistance-to-immune-checkpoint-inhibitors-in-lung-cancer
#16
Scott Gettinger, Jungmin Choi, Katherine Hastings, Anna Truini, Ila Datar, Ryan Sowell, Anna Wurtz, Weilai Dong, Guoping Cai, Mary Ann Melnick, Victor Y Du, Joseph Schlessinger, Sarah B Goldberg, Anne Chiang, Miguel F Sanmamed, Ignacio Melero, Jackeline Agorreta, Luis M Montuenga, Richard Lifton, Soldano Ferrone, Paula Kavathas, David L Rimm, Susan M Kaech, Kurt Schalper, Roy S Herbst, Katerina Politi
Mechanisms of acquired resistance to immune checkpoint inhibitors (ICI) are poorly understood. We leveraged a collection of 14 ICI-resistant lung cancer samples to investigate whether alterations in genes encoding HLA Class I antigen processing and presentation machinery (APM) components or interferon signaling play a role in acquired resistance to PD-1 or PD-L1 antagonistic antibodies. Recurrent mutations or copy-number changes were not detected in our cohort. In one case, we found acquired homozygous loss of B2M that caused lack of cell-surface HLA Class I expression in the tumor and a matched patient-derived xenograft (PDX)...
December 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28993985/gastroesophageal-reflux-after-sleeve-gastrectomy-a-prospective-mechanistic-study
#17
Muriel Coupaye, Caroline Gorbatchef, Daniela Calabrese, Ouidad Sami, Simon Msika, Benoit Coffin, Séverine Ledoux
BACKGROUND: Evolution of gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) is controversial. Some authors report worsening or improvement of preoperative GERD, others the occurrence of de novo GERD between 5 and 69%. AIMS: The aims of this study are to evaluate the evolution of GERD after SG by ambulatory 24-h pH monitoring (APM) and to determine pre- and postoperative clinical and manometric factors associated with its evolution. METHODS: Between 2013 and 2015, 47 patients operated in our center performed APM before and 1 year (14...
October 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28983220/similar-cost-savings-of-bundled-payment-initiatives-applied-to-lower-extremity-total-joint-arthroplasty-can-be-achieved-applying-both-models-2-and-3
#18
Allyson Alfonso, Lorraine Hutzler, Bill Robb, Chad Beste, André Blom, Joseph Bosco
BACKGROUND: In an effort to control cost and increase value, Medicare is transitioning from fee-for-service to value-based alternative payment models (APMs). The Bundled Payments for Care Improvement (BPCI) initiative represents one such voluntary APM. BPCI offers four different bundling options: model 1 covers all Diagnosis Related Groups (DRGs) and Models 2-4 cover 48 clinical episodes, including 186 separate DRGs. QUESTIONS/PURPOSES: The purpose of this investigation is to analyze and compare the cost savings achieved by two different BPCI program participants, provider A and provider B, enrolled in different models of BPCI (Models 2 and 3) for lower extremity joint replacements (LEJRs)...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28980974/analytical-probabilistic-modeling-of-rbe-weighted-dose-for-ion-therapy
#19
Hans-Peter Wieser, Philipp Hennig, Niklas Wahl, Mark Bangert
Particle therapy is especially prone to uncertainties. This issue is usually being addressed with uncertainty quantification and minimization techniques based on scenario sampling. For proton therapy, however, it was recently shown that it is also possible to use closed-form computations based on Analytical Probabilistic Modeling (APM) for this purpose. APM yields unique features compared to sampling-based approaches motivating further research in this context. This paper demonstrates the application of APM for intensity-modulated carbon ion therapy to quantify the influence of setup and range uncertainties on the RBE-weighted dose...
October 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28963077/payment-and-care-for-hematopoietic-cell-transplantation-patients-toward-a-specialized-medical-home-for-complex-care-patients
#20
James L Gajewski, Mark B McClellan, Navneet S Majhail, Parameswaran N Hari, Christopher N Bredeson, Richard T Maziarz, Charles F LeMaistre, Michael C Lill, Stephanie H Farnia, Krishna V Komanduri, Michael J Boo
Patient-centered medical home models are fundamental to the advanced alternative payment models defined in the Medicare Access and Children's Health Insurance Plan Reauthorization Act (MACRA). The patient-centered medical home is a model of healthcare delivery supported by alternative payment mechanisms and designed to promote coordinated medical care that is simultaneously patient-centric and population-oriented. This transformative care model requires shifting reimbursement to include a per-patient payment intended to cover services not previously reimbursed such as disease management over time...
September 28, 2017: Biology of Blood and Marrow Transplantation
keyword
keyword
119121
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"