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https://www.readbyqxmd.com/read/27923249/thyroid-function-in-human-obesity-underlying-mechanisms
#1
L C Fontenelle, M M Feitosa, J S Severo, T E C Freitas, J B S Morais, F L Torres-Leal, G S Henriques, D do Nascimento Marreiro
Obesity is associated with several metabolic and endocrine disorders; and changes in plasma concentrations, secretion patterns, and clearance of various hormones are observed in obese patients. In this context, recent research has shown that overweight can influence the function of the thyroid gland, usually leading to increased thyrotropin concentrations and changes in the ratio between the hormones triiodothyronine and thyroxine, though within the normal range. The etiology of these changes is still unclear; however, several mechanisms have been proposed including the adaptive process to increase energy expenditure, hyperleptinemia, changes in the activity of deiodinases, the presence of thyroid hormones resistance, chronic low-grade inflammation, and insulin resistance...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27923197/single-chain-fc-dimer-human-growth-hormone-fusion-protein-for-improved-drug-delivery
#2
Li Zhou, Hsuan-Yao Wang, Shanshan Tong, Curtis T Okamoto, Wei-Chiang Shen, Jennica L Zaro
Fc fusion protein technology has been successfully used to generate long-acting forms of several protein therapeutics. In this study, a novel Fc-based drug carrier, single chain Fc-dimer (sc(Fc)2), was designed to contain two Fc domains recombinantly linked via a flexible linker. Since the Fc dimeric structure is maintained through the flexible linker, the hinge region was omitted to further stabilize it against proteolysis and reduce FcγR-related effector functions. The resultant sc(Fc)2 candidate preserved the neonatal Fc receptor (FcRn) binding...
November 27, 2016: Biomaterials
https://www.readbyqxmd.com/read/27923182/sociodemographic-lifestyle-and-psychosocial-determinants-of-hair-cortisol-in-a-south-london-community-sample
#3
Susanne Fischer, Roman Duncko, Stephani L Hatch, Andrew Papadopoulos, Laura Goodwin, Souci Frissa, Matthew Hotopf, Anthony J Cleare
OBJECTIVE: Hypothalamic-pituitary-adrenal (HPA) measures are crucial for research into stress and stress-related disorders. Most HPA measures fluctuate depending on diurnal rhythms and state confounders. Hair cortisol concentrations (HCC) are less susceptible to such fluctuations, but less is known about trait-like confounders. Using a community sample, we tested the relationship between HCC and a range of variables including demographic variables, hair treatment, and medication, as well as psychosocial variables, namely childhood trauma, critical life events, and depressive symptoms...
November 17, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27923181/combined-oral-contraceptive-use-is-associated-with-both-improvement-and-worsening-of-mood-in-the-different-phases-of-the-treatment-cycle-a-double-blind-placebo-controlled-randomized-trial
#4
Cecilia Lundin, Kristina Gemzell Danielsson, Marie Bixo, Lena Moby, Hanna Bengtsdotter, Izabella Jawad, Lena Marions, Jan Brynhildsen, Agota Malmborg, Ingela Lindh, Inger Sundström Poromaa
OBJECTIVE: Ever since the introduction of combined oral contraception (COC), one of the major reasons for discontinuing the pill use has been mood-related side effects. Moreover, women who discontinue the pill turn to less effective methods whereby the probability of an unintended conception increases. Approximately 4-10% of COC users complain of depressed mood, irritability or increased anxiety, but drug-related causality has been difficult to prove. Given the lack of randomized controlled trials in this area, we aimed to prospectively estimate the severity of adverse mood in COC users that would be as representative of general users as possible...
November 29, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27923166/a-comparative-systematic-review-of-yasmin-drospirenone-pill-versus-standard-treatment-options-for-symptoms-of-polycystic-ovary-syndrome
#5
REVIEW
Jing Li, Jing Ren, Wenxia Sun
OBJECTIVES: To systematically review the impact of Yasmin (drospirenone pill) compares with other standard treatments for symptoms of Polycystic Ovary Syndrome (PCOS). STUDY DESIGN: The relevant studies of the randomized controlled trials in women with PCOS treated with drospirenone were retrieved and the systematic evaluation was conducted. RESULTS: Eighteen articles were included. Compared with drospirenone (DRSP) monotherapy, DRSP plus metformin was better in reducing body mass index (BMI), luteinizing hormone (LH) and low-density lipoprotein cholesterol (LDL-C)...
November 16, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27923118/cutting-out-the-middle-man-in-light-hormone-interactions
#6
Anna N Stepanova, Jose M Alonso
In this issue of Developmental Cell, Shi et al. (2016a) show that red-light-activated phytochrome B interacts with transcriptional regulators of ethylene signaling, EIN3/EIL1, triggering their degradation by bringing the F-box proteins EBF1 and 2 to the complex. These findings provide a paradigm for crosstalk between light and hormone signaling pathways.
December 5, 2016: Developmental Cell
https://www.readbyqxmd.com/read/27923036/cotargeting-of-cyp-19-aromatase-and-emerging-pivotal-signalling-pathways-in-metastatic-breast-cancer
#7
REVIEW
Stine Daldorff, Randi Margit Ruud Mathiesen, Olav Erich Yri, Hilde Presterud Ødegård, Jürgen Geisler
Aromatase inhibition is one of the cornerstones of modern endocrine therapy of oestrogen receptor-positive (ER+) metastatic breast cancer (MBC). The nonsteroidal aromatase inhibitors anastrozole and letrozole, as well as the steroidal aromatase inactivator exemestane, are the preferred drugs and established worldwide in all clinical phases of the disease. However, although many patients suffering from MBC experience an initial stabilisation of their metastatic burden, drug resistance and disease progression occur frequently, following in general only a few months on treatment...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27922936/the-rejoice-trial-a-phase-3-randomized-controlled-trial-evaluating-the-safety-and-efficacy-of-a-novel-vaginal-estradiol-soft-gel-capsule-for-symptomatic-vulvar-and-vaginal-atrophy
#8
Ginger D Constantine, James A Simon, James H Pickar, David F Archer, Harvey Kushner, Brian Bernick, Gina Gasper, Shelli Graham, Sebastian Mirkin
OBJECTIVE: To evaluate the safety and efficacy of TX-004HR vaginal estradiol soft-gel capsules for moderate-to-severe dyspareunia associated with postmenopausal vulvar and vaginal atrophy. METHODS: In this randomized, double-blind, placebo-controlled, phase 3 study, postmenopausal women with a self-identified most bothersome symptom of dyspareunia received 4, 10, or 25 μg TX-004HR or placebo for 12 weeks. Four co-primary efficacy endpoints were change from baseline to week 12 in percentages of superficial and parabasal cells, vaginal pH, and severity of dyspareunia...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922933/the-cross-sectional-association-between-vasomotor-symptoms-and-hemostatic-parameter-levels-in-postmenopausal-women
#9
Laura B Harrington, Marc Blondon, Mary Cushman, Andrew M Kaunitz, Jacques E Rossouw, Matthew A Allison, Lisa W Martin, Karen C Johnson, Jan Rosing, Nancy F Woods, Andrea Z LaCroix, Susan R Heckbert, Barbara McKnight, Nicholas L Smith
OBJECTIVE: Vasomotor symptoms (VMS) may be a marker of cardiovascular risk. We aimed to evaluate the cross-sectional association of VMS presence and severity with hemostatic parameter levels measured at baseline among Women's Health Initiative (WHI) Hormone Therapy trial postmenopausal participants. METHODS: This cross-sectional analysis included 2,148 postmenopausal women with measures of VMS presence and severity reported in the 4 weeks before WHI baseline, who were not using warfarin or hormone therapy and for whom the following baseline hemostatic parameters were measured within the WHI Cardiovascular Disease Biomarker Case-Control Study: antithrombin, plasminogen activator inhibitor-1, protein C antigen, total and free protein S antigen, total and free tissue factor pathway inhibitor, D-dimer, normalized activated protein C sensitivity ratio, and thrombin generation...
December 5, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27922822/serum-protein-mediators-of-dementia-and-aging-proper
#10
Donald R Royall, Safa Al-Rubaye, Ram Bishnoi, Raymond F Palmer
The latent variable "δ" (for "dementia") appears to be uniquely responsible for the dementing aspects of cognitive impairment. Age, depressive symptoms, gender and the apolipoprotein E (APOE) ε4 allele are independently associated with δ. In this analysis, we explore serum proteins as potential mediators of age's specific association with δ in a large, ethnically diverse longitudinal cohort, the Texas Alzheimer's Research and Care Consortium (TARCC). 22 serum proteins were recognized as partial mediators of age's association with δ...
December 3, 2016: Aging
https://www.readbyqxmd.com/read/27922667/pituitary-sex-hormones-enhance-the-pro%C3%A2-metastatic-potential-of-human-lung-cancer-cells-by-downregulating-the-intracellular-expression-of-heme-oxygenase%C3%A2-1
#11
Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Gabriela Schneider, Jacek Niklinski, Radoslaw Charkiewicz, Marcin Moniuszko, Magda Kucia, Mariusz Z Ratajczak
We report that human lung cancer cell lines express functional receptors for pituitary sex hormones (SexHs) and respond to stimulation by follicle‑stimulating hormone (FSH), luteinizing hormone (LH), and prolactin (PRL). Expression of these receptors has also been confirmed in patient lung cancer samples at the mRNA level. Stimulation of human lung cancer cell lines with FSH, LH, or PRL stimulated migration and chemotaxis, and some cell lines responded by enhanced proliferation. Moreover, priming of human lung cancer cells by exposing them to pituitary SexHs resulted in enhanced seeding efficiency of injected human lung cancer cells into bone marrow, liver, and lungs in an immunodeficient mouse model...
December 2, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27922639/mesolimbic-leptin-signaling-negatively-regulates-cocaine-conditioned-reward
#12
M Shen, C Jiang, P Liu, F Wang, L Ma
The regulatory mechanisms underlying the response to addictive drugs are complex, and increasing evidence indicates that there is a role for appetite-regulating pathways in substance abuse. Leptin, an important adipose hormone that regulates energy balance and appetite, exerts its physiological functions via leptin receptors. However, the role of leptin signaling in regulating the response to cocaine remains unclear. Here we examined the potential role of leptin signaling in cocaine reward using a conditioned place preference (CPP) procedure...
December 6, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27922279/clinical-experience-with-an-ovarian-stimulation-protocol-for-intrauterine-insemination-adopting-a-gonadotropin-releasing-hormone-antagonist-at-low-dose
#13
Adalisa Ponzano, Enrica Concetta Colangelo, Lucia Di Biase, Federica Romani, Gian Mario Tiboni
Studies testing the effectiveness of GnRH antagonists in controlled ovarian stimulation (COS) for intrauterine insemination (IUI) have provided controversial results. The present study was undertaken to evaluate, whether the use of a half of the conventional dose of the GnRH antagonist cetrorelix can be effective in increasing the successful rate of IUI cycles. Patients started COS with human menopausal gonadotropin (hMG) on day three of the menstrual cycle. Cetrorelix was started when at least one follicle of ≥14 mm, was detected at the ultrasound scan, according to the flexible multiple daily dose protocol, and continued until the trigger day with recombinant hCG...
December 6, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27922245/a-novel-mutation-in-a-case-of-pseudohypoparathyroidism-type-ia
#14
Birgül Kırel, Meliha Demiral, Özkan Bozdağ, Kadri Karaer
Pseudohypoparathyroidism (PHP) type Ia is characterized by multiple hormone resistance; primarily parathyroid hormone (PTH) resistance and Albright's hereditary osteodystrophy (AHO) which involves skeletal and developmental defects. The AHO phenotype alone without hormone resistance is defined as pseudoPHP. A boy was first diagnosed as having both rickets and primary hypothyroidism at 2.5 months of age. His calcium level remained within normal levels after vitamin D treatment, but, elevated PTH and ALP levels and normal-high phosphate levels persisted during his follow-up by age of 2...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27922125/an-er%C3%AE-agonist-induces-browning-of-subcutaneous-abdominal-fat-pad-in-obese-female-mice
#15
Yi-Fei Miao, Wen Su, Yu-Bing Dai, Wan-Fu Wu, Bo Huang, Rodrigo P A Barros, Hao Nguyen, Laure Maneix, You-Fei Guan, Margaret Warner, Jan-Åke Gustafsson
Estrogen, via estrogen receptor alpha (ERα), exerts several beneficial effects on metabolism and energy homeostasis by controlling size, enzymatic activity and hormonal content of adipose tissue. The actions of estrogen on sympathetic ganglia, which are key players in the browning process, are less well known. In the present study we show that ERβ influences browning of subcutaneous adipose tissue (SAT) via its actions both on sympathetic ganglia and on the SAT itself. A 3-day-treatment with a selective ERβ agonist, LY3201, induced browning of SAT in 1-year-old obese WT and ERα(-/-) female mice...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27922078/malat1-and-hotair-long-non-coding-rnas-play-opposite-role-in-estrogen-mediated-transcriptional-regulation-in-prostate-cancer-cells
#16
Aurora Aiello, Lorenza Bacci, Agnese Re, Cristian Ripoli, Francesco Pierconti, Francesco Pinto, Riccardo Masetti, Claudio Grassi, Carlo Gaetano, Pier Francesco Bassi, Alfredo Pontecorvi, Simona Nanni, Antonella Farsetti
In the complex network of nuclear hormone receptors, the long non-coding RNAs (lncRNAs) are emerging as critical determinants of hormone action. Here we investigated the involvement of selected cancer-associated lncRNAs in Estrogen Receptor (ER) signaling. Prior studies by Chromatin Immunoprecipitation (ChIP) Sequencing showed that in prostate cancer cells ERs form a complex with the endothelial nitric oxide synthase (eNOS) and that in turn these complexes associate with chromatin in an estrogen-dependent fashion...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27921452/simultaneous-profiling-of-17-steroid-hormones-for-the-evaluation-of-endocrine-disrupting-chemicals-in-h295r-cells
#17
Udi Jumhawan, Toshiyuki Yamashita, Kazuya Ishida, Eiichiro Fukusaki, Takeshi Bamba
AIM: There is urgent need to develop a new protocol for the evaluation of chemical substances to potentially interact with the endocrine system and induce numerous pathological issues. The recently validated in vitro screening assay is limited on monitoring two steroid hormones. Methodology & results: The H295R model cell was exposed to seven endocrine disrupting chemicals (EDCs). The levels of 17 steroid hormones in cell extracts were subsequently determined by a quantitative targeted GC/MS/MS method...
January 2017: Bioanalysis
https://www.readbyqxmd.com/read/27921427/-growth-hormone-axis-gh-igf1-and-glucose-metabolism
#18
Michal Kršek
Growth hormone is a hormone of anterior lobe of pituitary gland which possesses besides its growth promoting effects also many other various physiological effects including its regulatory influences on metabolism with glucose metabolism belonging to most important ones. The present article summarizes basic information about metabolic consequences of disturbed growth hormone secretion and their importance for clinical presentation and management.Key words: acromegaly - glucose - growth hormone - growth hormone deficiency - IGF1 - metabolism...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27921379/fibroids-that-do-not-distort-the-uterine-cavity-and-ivf-success-rates-an-observational-study-using-extensive-matching-criteria
#19
G Christopoulos, A Vlismas, R Salim, R Islam, G Trew, S Lavery
OBJECTIVE: To assess the impact of non-cavity-distorting fibroids on in vitro fertilisation (IVF) pregnancy outcomes. DESIGN: A retrospective, matched, single-centre, cohort study was performed. SETTING: The IVF unit of a tertiary, university hospital. POPULATION: We analysed all women with non-cavity-distorting uterine fibroids undergoing IVF/intracytoplasmic sperm injection (ICSI) cycles from 1 January 2011 to 1 May 2015...
December 5, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27921341/unexpected-effect-of-the-vehicle-grain-ethanol-of-homeopathic-fsh-on-the-in-vitro-survival-and-development-of-isolated-ovine-preantral-follicles
#20
Lartiza F Lima, Rebeca M P Rocha, Ana Beatriz G Duarte, Ivina R Brito, Gerlane M Silva, Giovanna Q Rodrigues, Diana C S Nunes-Pinheiro, Antônia D Sales, Arlindo A Moura, Matthew B Wheeler, Ana Paula R Rodrigues, Cláudio C Campello, José Ricardo Figueiredo
The aims of this study were to investigate the effects of medium replacement system (experiment I) and of FSH presentations (homeopathic - FSH 6cH and allopathic FSH - rFSH; experiment II) on the in vitro development, hormone production and gene expression of isolated ovine preantral follicles cultured for 6 days. In experiment I, secondary follicles were cultured in the α-MEM(+) supplemented with FSH 6cH (0.05 fg/ml) or recombinant bovine FSH (100 ng/ml) without/with daily medium addition. The homeopathic FSH treatments with/without medium addition improved (p < ...
December 5, 2016: Microscopy Research and Technique
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