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citrate locking solution

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https://www.readbyqxmd.com/read/29106676/safety-and-efficacy-of-taurolidine-urokinase-versus-taurolidine-heparin-as-a-tunneled-catheter-lock-solution-in-hemodialysis-patients-a-prospective-randomized-controlled-study
#1
Fadwa Al-Ali, Ahmad F Hamdy, Abdullah Hamad, Mohamed Elsayed, Zafar Zafar Iqbal, Aisha Elsayed, Rania Ibrahim, Hoda Tolba, Hisham Buanan, Ashraf Fawzy
Background: Taurolidine citrate with heparin (Taurolock/Hep) is a promising central venous catheter lock solution. Despite its universal use among our hemodialysis patients, the prevalence of catheter malfunction was high. We aimed to compare Taurolock/Hep and taurolidine citrate with urokinase (Taurolock/U) as a catheter lock solution in order to identify whether either solution could reduce catheter-related dysfunction. Methods: In this prospective, randomized, controlled trial, patients were randomized to receive either Taurolock/Hep or Taurolock/U and were followed for 6 months...
July 4, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28890326/taurolidine-based-catheter-lock-regimen-significantly-reduces-overall-costs-infection-and-dysfunction-rates-of-tunneled-hemodialysis-catheters
#2
Wolfgang Winnicki, Harald Herkner, Matthias Lorenz, Ammon Handisurya, Željko Kikić, Bernhard Bielesz, Benjamin Schairer, Thomas Reiter, Farsad Eskandary, Gere Sunder-Plassmann, Guerkan Sengoelge
Catheter-related infections and dysfunction are the main catheter complications causing morbidity and mortality in hemodialysis patients. However, there are no consistent data for the choice of catheter lock solutions for tunneled hemodialysis lines. In this prospective, multicenter, randomized, controlled trial, two lock regimens using three commercial catheter lock solutions were compared in 106 hemodialysis patients with a newly inserted tunneled central catheter. In the taurolidine group, TauroLock™-Hep500 was used twice per week and TauroLock™-U25,000 once a week...
September 7, 2017: Kidney International
https://www.readbyqxmd.com/read/28793993/taurolidine-citrate-heparin-lock-reduces-catheter-related-bloodstream-infections-in-intestinal-failure-patients-dependent-on-home-parenteral-support-a-randomized-placebo-controlled-trial
#3
RANDOMIZED CONTROLLED TRIAL
Siri Tribler, Christopher F Brandt, Anne H Petersen, Jørgen H Petersen, Kristian A Fuglsang, Michael Staun, Per Broebech, Claus E Moser, Palle B Jeppesen
Background: In patients with intestinal failure who are receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) inflict health impairment and high costs.Objective: This study investigates the efficacy and safety of the antimicrobial catheter lock solution, taurolidine-citrate-heparin, compared with heparin 100 IE/mL on CRBSI occurrence.Design: Forty-one high-risk patients receiving HPS followed in a tertiary HPS unit were randomly assigned in a double-blinded, placebo-controlled trial...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28623638/urokinase-containing-locking-solution-in-the-prevention-of-dialysis-catheter-dysfunction-a-double-blind-randomized-controlled-trial
#4
Florence Bonkain, Freya Van Hulle, Peter Janssens, Concetta Catalano, Mandelina Allamani, Jean-Claude Stolear, Dominique Vandervelde, Mark Libertalis, Serge Treille, Marie M Couttenye, Annemie Dhondt, Wim Van Biesen, Jean François Fils, Christian Tielemans, Karl M Wissing
INTRODUCTION: The prophylactic use of recombinant tissue plasminogen activator once weekly reduces the incidence rate of tunneled cuffed catheter (TCC) malfunction and bacteremia as compared to the exclusive use of heparin as locking solution. Restricting the use of prophylactic thrombolytic agents to patients with a history of thrombotic TCC malfunction could be more cost effective. We conduct a multicenter, double-blind, randomized controlled trial and test the hypothesis that weekly use of urokinase lock will reduce the incidence of thrombotic malfunction by 50% in prevalent hemodialysis patients with a history of thrombotic malfunction...
June 14, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28463827/taurolidine-citrate-lock-therapy-for-primary-prevention-of-catheter-related-infections-in-cancer-patients-results-of-a-prospective-randomized-phase-iv-trial-atapac
#5
RANDOMIZED CONTROLLED TRIAL
Raffaele Longo, Mathieu Llorens, Christophe Goetz, Christian Platini, Nada Eid, Jocelyne Sellies, Nadia Ouamara, Philippe Quétin
BACKGROUND: Totally implantable venous access port (TIVAP)-related infections (RIs) remain a serious health problem in cancer patients receiving an intravenous (i.v.) therapy. PATIENTS AND METHODS: The ATAPAC study was a prospective, randomized, monocentric, phase IV trial evaluating the efficacy of taurolidine lock solution versus standard saline solution for primary TIVAP-RI prevention in nonhematological cancer patients receiving i.v. chemotherapy. The primary endpoint was the TIVAP-RI incidence rate...
2017: Oncology
https://www.readbyqxmd.com/read/28429519/the-incidence-and-costs-of-bacteremia-due-to-lack-of-gentamicin-lock-solutions-for-dialysis-catheters
#6
Tze Liang Goh, Jason Wei, David Semple, John Collins
The use of antibiotic lock solutions as prophylaxis for catheter-associated blood stream infection (CRBSI) has been shown to be effective in previous randomized controlled trials. However, the cost-effectiveness of this approach had not been studied. In 2012, the routine gentamicin-heparin lock solution used in Auckland City Hospital was withdrawn from the market, leading to a change to heparin-only lock. This was then replaced with gentamicin-citrate lock in 2014. This situation allowed review of the CRBSI rate and financial impact of different catheter lock solutions...
June 2017: Nephrology
https://www.readbyqxmd.com/read/28416559/a-novel-nonantibiotic-nitroglycerin-based-catheter-lock-solution-for-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#7
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Amin Sapna, Andrew Assaf, Yazan Numan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
For long-term central lines (CL), the lumen is the major source of central line-associated bloodstream infections (CLABSI). The current standard of care for maintaining catheter patency includes flushing the CL with saline or heparin. Neither agent has any antimicrobial activity. Furthermore, heparin may enhance staphylococcal biofilm formation. We evaluated the safety and efficacy of a novel nonantibiotic catheter lock solution for the prevention of CLABSI. Between November 2015 and February 2016, we enrolled 60 patients with hematologic malignancies who had peripherally inserted central catheters (PICC) to receive the study lock solution...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28297055/any-use-for-alternative-lock-solutions-in-the-prevention-of-catheter-related-blood-stream-infections
#8
REVIEW
Laura Labriola, Jean-Michel Pochet
The prevention of catheter-related blood stream infections (CRBSI) in hemodialysis (HD) patients remains a challenge because of high morbidity and mortality associated to CRBSI. Alternative locking solutions (ALS) containing an antithrombotic substance with additional antimicrobial or antibiofilm properties (citrate, ethylenediaminetetraacetic acid [EDTA], 70% ethanol, thrombolytics) with or without the addition of molecules with specific antimicrobial activity (antibiotics, taurolidine, paraben-methylene-blue) has been proposed with the aim to prevent or eradicate intraluminal biofilm colonization and subsequent CRBSI...
March 6, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28287523/use-of-sacrificial-nanoparticles-to-remove-the-effects-of-shot-noise-in-contact-holes-fabricated-by-e-beam-lithography
#9
Shankar B Rananavare, Moshood K Morakinyo
Nano-patterns fabricated with extreme ultraviolet (EUV) or electron-beam (E-beam) lithography exhibit unexpected variations in size. This variation has been attributed to statistical fluctuations in the number of photons/electrons arriving at a given nano-region arising from shot-noise (SN). The SN varies inversely to the square root of a number of photons/electrons. For a fixed dosage, the SN is larger in EUV and E-beam lithographies than for traditional (193 nm) optical lithography. Bottom-up and top-down patterning approaches are combined to minimize the effects of shot noise in nano-hole patterning...
February 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28035620/does-antimicrobial-lock-solution-reduce-catheter-related-infections-in-hemodialysis-patients-with-central-venous-catheters-a-bayesian-network-meta-analysis
#10
REVIEW
Jun Zhang, Bo Wang, Rongke Li, Long Ge, Kee-Hsin Chen, Jinhui Tian
PURPOSE: The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial lock solutions (ALS) for prevention of catheter-related infections (CRI) in patients with hemodialysis (HD) and ranking these ALS for practical consideration. METHODS: We searched six electronic databases, earlier relevant meta-analysis and reference lists of included studies for randomized controlled trials (RCTs) that compared ALS for preventing episodes of CRI in patients with HD either head-to-head or against control interventions using non-ALS...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/27670267/the-clock-trial-a-double-blinded-randomized-controlled-trial-trisodium-citrate-30-and-minocycline-3-mg-ml-plus-edta-30-mg-ml-are-effective-and-safe-for-catheter-patency-maintenance-among-ckd-5d-patients-on-hemodialysis
#11
RANDOMIZED CONTROLLED TRIAL
Marcus V S João Luiz, Cristoforo Scavone, Carmen Tzanno
INTRODUCTION: Poor blood flow rate (PF) is highly prevalent among CKD 5D patients with long-term central venous catheters. Heparin catheter lock solutions are commonly used to maintain catheter patency, however the incidence of PF remains high. The purpose of the CLOCK Trial was to evaluate two catheter lock solutions on reduction of PF incidence. METHODS: Seventy-five CKD 5D patients on high-efficiency hemodialysis at the Integrated Centre of Nephrology (Guarulhos, Brazil) were randomized 1:1:1 to receive a lock solution combining minocycline 3 mg/mL with the anticoagulant/chelation agent EDTA 30 mg/mL (M-EDTA) or heparin 1000 IU/mL (H) or trisodium citrate 30% (TSC) vs...
April 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27573387/comparative-effectiveness-of-30%C3%A2-trisodium-citrate-and-heparin-lock-solution-in-preventing-infection-and-dysfunction-of-hemodialysis-catheters-a-randomized-controlled-trial-citrim-trial
#12
RANDOMIZED CONTROLLED TRIAL
Franklin Correa Barcellos, Bruno Pereira Nunes, Luciana Jorge Valle, Thiago Lopes, Bianca Orlando, Cintia Scherer, Marcia Nunes, Gabriela Araújo Duarte, Maristela Böhlke
BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed for patients without definitive vascular access. However, CVC is associated with complications, such as infection, thrombosis, and dysfunction, leading to higher mortality and expenditures. The aim of this study was to compare the effectiveness of 30 % trisodium citrate (TSC30 %) with heparin as CVC lock solutions in preventing catheter-related bloodstream infections (CRBSI) and dysfunction in hemodialysis patients...
April 2017: Infection
https://www.readbyqxmd.com/read/27516141/evidence-based-criteria-for-the-choice-and-the-clinical-use-of-the-most-appropriate-lock-solutions-for-central-venous-catheters-excluding-dialysis-catheters-a-gavecelt-consensus
#13
REVIEW
Mauro Pittiruti, Sergio Bertoglio, Giancarlo Scoppettuolo, Roberto Biffi, Massimo Lamperti, Alberto Dal Molin, Nicola Panocchia, Nicola Petrosillo, Mario Venditti, Carla Rigo, Enrico DeLutio
BACKGROUND: The most appropriate lock solution for central venous access devices is still to be defined. GAVeCeLT - the Italian group for venous access devices - has developed a consensus on the evidence-based criteria for the choice and the clinical use of the most appropriate lock solution for central venous catheters (excluding dialysis catheters). METHOD: After the constitution of a panel of experts, a systematic collection and review of the literature has been performed, focusing on clinical studies dealing with lock solutions used for prevention of occlusion (heparin, citrate, urokinase, recombinant tissue plasminogen activator [r-TPA], normal saline) or for prevention of infection (citrate, ethanol, taurolidine, ethylene-diamine-tetra-acetic acid [EDTA], vancomycin, linezolid and other antibiotics), in both adults and in pediatric patients...
November 2, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27390716/is-taurolidine-citrate-an-effective-and-cost-effective-hemodialysis-catheter-lock-solution-a-systematic-review-and-cost-effectiveness-analysis
#14
Zahra Kavosi, Maryam Sarikhani Khorrami, Khosro Keshavarz, Abdosaleh Jafari, Amir Hashemi Meshkini, Hamid Reza Safaei, Shekoufeh Nikfar
BACKGROUND: Prevention of catheter-related infection is of prime importance,. However, because of the risks caused by the leakage of circulating antibiotics and development of resistance to antibiotics, they are replaced by lock solutions. The aim of this study was to evaluate the efficacy and cost- effectiveness of taurolidine-citrate as a hemodialysis catheter lock solution compared to other common alternatives in Iran. METHODS: To evaluate the efficacy of taurolidine-citrate, a systematic review was conducted by searching electronic databases...
2016: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/27297475/in-vitro-assessment-of-the-antimicrobial-efficacy-of-optimized-nitroglycerin-citrate-ethanol-as-a-nonantibiotic-antimicrobial-catheter-lock-solution-for-prevention-of-central-line-associated-bloodstream-infections
#15
Ruth A Reitzel, Joel Rosenblatt, Cheryl Hirsh-Ginsberg, Kimberly Murray, Anne-Marie Chaftari, Ray Hachem, Issam Raad
The rapid, broad-spectrum, biofilm-eradicating activity of the combination of 0.01% nitroglycerin, 7% citrate, and 20% ethanol and its potential as a nonantibiotic, antimicrobial catheter lock solution (ACLS) were previously reported. Here, a nitroglycerin-citrate-ethanol (NiCE) ACLS optimized for clinical assessment was developed by reducing the nitroglycerin and citrate concentrations and increasing the ethanol concentration. Biofilm-eradicating activity was sustained when the ethanol concentration was increased from 20 to 22% which fully compensated for reducing the citrate concentration from 7% to 4% as well as the nitroglycerin concentration from 0...
September 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27039404/anticoagulants-and-antiplatelet-agents-for-preventing-central-venous-haemodialysis-catheter-malfunction-in-patients-with-end-stage-kidney-disease
#16
REVIEW
Ying Wang, Jessica N Ivany, Vlado Perkovic, Martin P Gallagher, Mark Woodward, Meg J Jardine
BACKGROUND: Catheter malfunction, including thrombosis, is associated with reduced dialysis adequacy, as well as an increased risk of catheter-related bacteraemia and mortality. The role of anticoagulants in the prevention of catheter malfunction remains uncertain. OBJECTIVES: This review aimed to compare the prophylactic effect of different anticoagulant agents, preparations, doses and administration on the incidence of central venous haemodialysis catheter-related malfunction and sepsis in patients with end-stage kidney disease (ESKD)...
April 4, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26660041/an-ethanol-sodium-citrate-locking-solution-compared-to-heparin-to-prevent-hemodialysis-catheter-related-infections-a-randomized-pilot-study
#17
RANDOMIZED CONTROLLED TRIAL
Lavern M Vercaigne, Don R Allan, Sean W Armstrong, James M Zacharias, Lisa M Miller
PURPOSE: The objective of this study was to compare the initial safety and efficacy of a novel 30% ethanol/4% sodium citrate catheter-locking solution to heparin in a hemodialysis population. METHODS: This was a prospective, randomized, pilot study of 40 hemodialysis patients randomized to a 30% ethanol/4% sodium citrate or heparin 1000 units/mL locking solution. The primary outcome was identification of any serious adverse events over the study duration. Secondary outcomes included the rate per 1000 catheter days for catheter-related bloodstream infections (CRBSI), alteplase use, catheter dysfunction, and catheter removal...
January 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/26614260/retracted-%C3%A2-article-anticoagulant-agents-for-the-prevention-of-hemodialysis-catheter-related-complications-systematic-review-and-meta-analysis-of-prospective-randomized-controlled-trials
#18
REVIEW
Jinrui Liu, Chang'an Wang, Hongfei Zhao, Jinghua Zhang, Jie Ma, Yuanyuan Hou, Hongbin Zou
No abstract text is available yet for this article.
July 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/26550111/anticoagulant-therapies-versus-heparin-for-the-prevention-of-hemodialysis-catheter-related-complications-systematic-review-and-meta-analysis-of-prospective-randomized-controlled-trials
#19
Jinrui Liu, Chang'an Wang, Hongfei Zhao, Jinghua Zhang, Jie Ma, Yuanyuan Hou, Hongbin Zou
Locking of central venous catheters with heparin is an accepted practice to maintain catheter patency between dialysis sessions. However, this practice may cause other adverse reactions. Although many studies suggest benefits of other catheter lock solutions over heparin on these grounds, no consensus has been reached for clinical practice. A systematic review and meta-analysis was performed of randomized controlled trials (RCT) that compared antimicrobial-containing or citrate-alone catheter lock solutions with heparin alone in patients undergoing hemodialysis with central venous catheters...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25960883/risk-factors-associated-with-hemodialysis-central-venous-catheter-malfunction-a-retrospective-analysis-of-a-randomized-controlled-trial
#20
David R Ward, Louise M Moist, Jennifer M MacRae, Nairne Scott-Douglas, Jianguo Zhang, Marcello Tonelli, Charmaine E Lok, Steven D Soroka, Brenda R Hemmelgarn
BACKGROUND: We previously reported a reduction in central venous catheter (CVC) malfunction when using once-weekly recombinant tissue-plasminogen activator (rt-PA) as a locking solution, compared with thrice-weekly heparin. OBJECTIVES: To identify risk factors for CVC malfunction to inform a targeted strategy for rt-PA use. DESIGN: Retrospective analysis. SETTING: Canadian hemodialysis (HD) units. PATIENTS: Adults with newly placed tunnelled upper venous system CVCs randomized to a locking solution of rt-PA(1 mg/mL) mid-week and heparin (5000 u/ml) on the other HD sessions, or thrice-weekly heparin (5000 u/ml)...
2014: Canadian Journal of Kidney Health and Disease
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