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https://www.readbyqxmd.com/read/29027526/-investigation-of-the-structure-of-a-functionally-intact-xenopericardial-bioconduit-after-long-term-implantation
#1
R A Mukhamadiyarov, N V Rutkovskaya, I V Milto, O D Sidopova, Yu А Kudryavtseva, L S Barbarash
AIM: to investigate the cellular composition of a functionally intact xenopericardial valve in a recipient with acquired mitral defect after long-term implantation. MATERIAL AND METHODS: A Uniline bioconduit (BC) ('Neocor', Kemerovo) removed from the heart in the mitral position at 7.2 years after implantation was investigated. Heart valve leaflets were fixed in a buffered 4% paraformaldehyde solution and imbedded in paraffin or epoxy resin. Slices made from the paraffin samples were stained with hematoxylin and eosin or underwent immunohistochemical (IHC) examination for typing endothelial cells, smooth muscle cells, macrophages, fibroblasts, and T and B lymphocytes...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28747538/complexing-agents-and-ph-influence-on-chemical-durability-of-type-i-molded-glass-containers
#2
Alberto Biavati, Michele Poncini, Arianna Ferrarini, Nicola Favaro, Martina Scarpa, Marta Vallotto
Among the factors that affect the glass surface chemical durability, pH and complexing agents present in aqueous solution have the main role. Glass surface attack can be also related to the delamination issue causing glass particles' appearance in the pharmaceutical preparation. A few methods to check for glass containers delamination propensity and some control guidelines have been proposed. The present study emphasizes the possible synergy between a few complexing agents with pH on borosilicate glass chemical durability...
July 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28629076/effect-of-acute-and-long-term-administration-of-gold-nanoparticles-on-biochemical-parameters-in-rat-brain
#3
Gabriela K Ferreira, Eria Cardoso, Francieli Silva Vuolo, Letícia Selinger Galant, Monique Michels, Cinara L Gonçalves, Gislaine Tezza Rezin, Felipe Dal-Pizzol, Roberto Benavides, Gabriel Alonso-Núñez, Vanessa Moraes Andrade, Emilio L Streck, Marcos Marques da Silva Paula
The present study investigated stress oxidative parameters and activities of enzymes of the energy metabolism in various brain structures. Rats were subjected to acute and long-term administration of gold nanoparticles (GNPs) with mean diameters of 10nm and 30nm. Adult (60days old) male Wistar rats received a single intraperitoneal injection (acute administration; 70μg·kg(-1)) or repeated injections once daily for 28days (long-term administration; 70μg·kg(-1)) of saline solution or GNPs (10nm or 30nm). Twenty-four hours after administration of the final dose, the animals were killed and the cerebral structures were isolated for enzyme analysis...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28604877/understanding-and-improving-aggregated-gold-nanoparticle-dsdna-interactions-by-molecular-spectroscopy-and-deconvolution-methods
#4
Jose M Carnerero, Aila Jimenez-Ruiz, Elia M Grueso, Rafael Prado-Gotor
It is well known that single-stranded DNA (ssDNA) is easily able to adsorb on citrate-capped, non-functionalized gold nanoparticles (AuNPs). However, the affinity of double-stranded DNA (dsDNA) for them is much more limited. The present work demonstrates that long dsDNA suffers from a bending conformational change when anionic nanoparticles are present in solution. A striking decrease in the persistence length of the double helix in the absence of salt is observed through dynamic light scattering (DLS), viscometric, and atomic force microscopy (AFM) methods...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28416559/a-novel-nonantibiotic-nitroglycerin-based-catheter-lock-solution-for-prevention-of-intraluminal-central-venous-catheter-infections-in-cancer-patients
#5
Anne-Marie Chaftari, Ray Hachem, Ariel Szvalb, Mahnaz Taremi, Bruno Granwehr, George Michael Viola, Amin Sapna, Andrew Assaf, Yazan Numan, Pankil Shah, Ketevan Gasitashvili, Elizabeth Natividad, Ying Jiang, Rebecca Slack, Ruth Reitzel, Joel Rosenblatt, Elie Mouhayar, Issam Raad
For long-term central lines (CL), the lumen is the major source of central line-associated bloodstream infections (CLABSI). The current standard of care for maintaining catheter patency includes flushing the CL with saline or heparin. Neither agent has any antimicrobial activity. Furthermore, heparin may enhance staphylococcal biofilm formation. We evaluated the safety and efficacy of a novel nonantibiotic catheter lock solution for the prevention of CLABSI. Between November 2015 and February 2016, we enrolled 60 patients with hematologic malignancies who had peripherally inserted central catheters (PICC) to receive the study lock solution...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28327741/new-polyaminocarboxylate-macrocycles-containing-phenolate-binding-units-synthesis-luminescent-and-relaxometric-properties-of-their-lanthanide-complexes
#6
Morgane Enel, Nadine Leygue, Stéphane Balayssac, Sophie Laurent, Chantal Galaup, Luce Vander Elst, Claude Picard
The synthesis of two new polyaminocarboxylate macrocycles incorporating one or two intracyclic phenol units (H4L(1) and H8L(2), respectively) is described. The 12-membered H4L(1) macrocycle leads to soluble and stable mononuclear Ln(III) complexes of [(L(1))Ln(H2O)2](-) composition (Ln = Eu, Tb and Gd) in aqueous solutions. In Tris buffer (pH 7.4), the [(L(1))Tb(H2O)2](-) complex displays a suitable efficiency for sensitized emission (ηsens = 48%) and a high luminescence quantum yield (Φ = 22%), which is worthy of note for a bis-hydrated terbium complex...
March 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28035620/does-antimicrobial-lock-solution-reduce-catheter-related-infections-in-hemodialysis-patients-with-central-venous-catheters-a-bayesian-network-meta-analysis
#7
REVIEW
Jun Zhang, Bo Wang, Rongke Li, Long Ge, Kee-Hsin Chen, Jinhui Tian
PURPOSE: The purpose of our study is to carry out a Bayesian network meta-analysis comparing the efficacy of different antimicrobial lock solutions (ALS) for prevention of catheter-related infections (CRI) in patients with hemodialysis (HD) and ranking these ALS for practical consideration. METHODS: We searched six electronic databases, earlier relevant meta-analysis and reference lists of included studies for randomized controlled trials (RCTs) that compared ALS for preventing episodes of CRI in patients with HD either head-to-head or against control interventions using non-ALS...
April 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/27984227/physical-compatibility-of-propofol-sufentanil-mixtures
#8
Jarmila Zbytovská, Jana Gallusová, Lucie Vidlářová, Kamila Procházková, Jan Šimek, František Štěpánek
BACKGROUND: Combined infusions of propofol and sufentanil preparations are frequently used in clinical practice to induce anesthesia and analgesia. However, the stability of propofol emulsions can be affected by dilution with another preparation, sometimes leading to particle coalescence and enlargement. Such unwanted effects can lead to fat embolism syndrome after intravenous application. This study describes the physical stability of 5 commercially available propofol preparations mixed with sufentanil citrate solutions...
March 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27865859/solubilization-of-proteins-in-aqueous-two-phase-extraction-through-combinations-of-phase-formers-and-displacement-agents
#9
Christian Kress, Gabriele Sadowski, Christoph Brandenbusch
The aqueous two-phase extraction (ATPE) of therapeutic proteins is a promising separation alternative to cost-intensive chromatography, still being the workhorse of nowadays downstream processing. As shown in many publications, using NaCl as displacement agent in salt-polymer ATPE allows for a selective purification of the target protein immunoglobulin G (IgG) from human serum albumin (HSA, represents the impurity). However a high yield of the target protein is only achievable as long as the protein is stabilized in solution and not precipitated...
March 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27844288/methylphenidate-decreases-atp-levels-and-impairs-glutamate-uptake-and-na-k-atpase-activity-in-juvenile-rat-hippocampus
#10
Felipe Schmitz, Paula Pierozan, André F Rodrigues, Helena Biasibetti, Mateus Grings, Bruna Zanotto, Daniella M Coelho, Carmen R Vargas, Guilhian Leipnitz, Angela T S Wyse
The study of the long-term neurological consequences of early exposure with methylphenidate (MPH) is very important since this psychostimulant has been widely misused by children and adolescents who do not meet full diagnostic criteria for ADHD. The aim of this study was to examine the effect of early chronic exposure with MPH on amino acids profile, glutamatergic and Na(+),K(+)-ATPase homeostasis, as well as redox and energy status in the hippocampus of juvenile rats. Wistar male rats received intraperitoneal injections of MPH (2...
December 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/27823671/in-situ-hydrazine-reduced-silver-colloid-synthesis-enhancing-sers-reproducibility
#11
Vera Dugandžić, Izabella Jolan Hidi, Karina Weber, Dana Cialla-May, Jürgen Popp
Herein we report a novel strategy for the in situ synthesis of the silver colloids for LoC-SERS applications. Silver nanoparticles are obtained in a segmented flow based glass microfluidic chip by the reduction of silver ions with hydrazine in ammonium hydroxide solution. Citrate ions are used as protecting agents. The synthesized nanoparticles are characterized by UV-VIS spectroscopy, SEM and TEM imaging. The SERS performance of the in situ synthesized nanoparticles is tested by using adenine as a test analyte right after the colloid synthesis...
November 23, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27779114/novel-one-pot-and-facile-room-temperature-synthesis-of-gold-nanodots-and-application-as-highly-sensitive-and-selective-probes-for-cyanide-detection
#12
Nagamalai Vasimalai, Maria T Fernandez-Arguelles
Highly fluorescent gold nanodots have been synthesized through a novel rapid, facile and one-pot room temperature route using trithiocyanuric acid as mild reducing agent and surface ligand. The proposed synthesis overcomes limitations of other synthetic routes in terms of cost, time, complexity and environmental risks, and gives rise to highly fluorescent gold nanodots within 10 min at room temperature, with a maximum emission wavelength at 623 nm and a large Stokes shift (213 nm). Moreover, the synthesized gold nanodots showed a large emission QY (9...
November 25, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27670267/the-clock-trial-a-double-blinded-randomized-controlled-trial-trisodium-citrate-30-and-minocycline-3-mg-ml-plus-edta-30-mg-ml-are-effective-and-safe-for-catheter-patency-maintenance-among-ckd-5d-patients-on-hemodialysis
#13
RANDOMIZED CONTROLLED TRIAL
Marcus V S João Luiz, Cristoforo Scavone, Carmen Tzanno
INTRODUCTION: Poor blood flow rate (PF) is highly prevalent among CKD 5D patients with long-term central venous catheters. Heparin catheter lock solutions are commonly used to maintain catheter patency, however the incidence of PF remains high. The purpose of the CLOCK Trial was to evaluate two catheter lock solutions on reduction of PF incidence. METHODS: Seventy-five CKD 5D patients on high-efficiency hemodialysis at the Integrated Centre of Nephrology (Guarulhos, Brazil) were randomized 1:1:1 to receive a lock solution combining minocycline 3 mg/mL with the anticoagulant/chelation agent EDTA 30 mg/mL (M-EDTA) or heparin 1000 IU/mL (H) or trisodium citrate 30% (TSC) vs...
April 2017: Hemodialysis International
https://www.readbyqxmd.com/read/27593160/isoexergonic-conformations-of-surface-bound-citrate-regulated-bioinspired-apatite-nanocrystal-growth
#14
Ziqiu Wang, Zhijun Xu, Weilong Zhao, Wei Chen, Toshikazu Miyoshi, Nita Sahai
The superior biomechanical properties of bone and dentin are dictated, in part, by the unique plate-like morphology of hydroxyapatite (HAP) nanocrysals within a hierarchically assembled collagen matrix. Understanding the mechanism of crystal growth and thus morphology is important to the rational design of bioinspired apatite nanocrystals for orthopedic and dental applications. Citrate has long been proposed to modulate apatite crystal growth, but major questions exist regarding the HAP-bound citrate conformations and the identities of the interacting functional groups and HAP surface sites...
October 5, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27500213/cyclic-helix-b-peptide-in-preservation-solution-and-autologous-blood-perfusate-ameliorates-ischemia-reperfusion-injury-in-isolated-porcine-kidneys
#15
Cheng Yang, Sarah A Hosgood, Patel Meeta, Yaqiu Long, Tongyu Zhu, Michael L Nicholson, Bin Yang
UNLABELLED: There is a critical need to better preserve isolated organs before transplantation. We developed a novel nonerythropoiesis cyclic helix B peptide (CHBP) derived from erythropoietin, which has potent tissue protection and prolonged serum stability. The renoprotection and potential mechanism of CHBP were evaluated in a kidney preservation model. MATERIALS AND METHODS: Porcine kidneys (n = 5) subjected to 20-minute warm ischemia were retrieved and flushed with hyperosmolar citrate to mimic deceased donation...
March 2015: Transplantation Direct
https://www.readbyqxmd.com/read/27222612/formulation-development-process-optimization-and-in-vitro-characterization-of-spray-dried-lansoprazole-enteric-microparticles
#16
Chintan Vora, Riddhish Patadia, Karan Mittal, Rajashree Mashru
This research focuses on the development of enteric microparticles of lansoprazole in a single step by employing the spray drying technique and studies the effects of variegated formulation/process variables on entrapment efficiency and in vitro gastric resistance. Preliminary trials were undertaken to optimize the type of Eudragit and its various levels. Further trials included the incorporation of plasticizer triethyl citrate and combinations of other polymers with Eudragit S 100. Finally, various process parameters were varied to investigate their effects on microparticle properties...
April 2016: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/26971068/gene-delivery-using-calcium-phosphate-nanoparticles-optimization-of-the-transfection-process-and-the-effects-of-citrate-and-poly-l-lysine-as-additives
#17
Mohammed A Khan, Victoria M Wu, Shreya Ghosh, Vuk Uskoković
Despite the long history of nanoparticulate calcium phosphate (CaP) as a non-viral transfection agent, there has been limited success in attempts to optimize its properties for transfection comparable in efficiency to that of viral vectors. Here we focus on the optimization of: (a) CaP nanoparticle precipitation conditions, predominantly supersaturation and Ca/P molar ratios; (b) transfection conditions, mainly the concentrations of the carrier and plasmid DNA; (c) the presence of surface additives, including citrate anion and cationic poly(l-lysine) (PLL)...
June 1, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/26969510/a-method-to-preserve-low-parasitaemia-plasmodium-infected-avian-blood-for-host-and-vector-infectivity-assays
#18
Jenny S Carlson, Federico Giannitti, Gediminas Valkiūnas, Lisa A Tell, Joy Snipes, Stan Wright, Anthony J Cornel
BACKGROUND: Avian malaria vector competence studies are needed to understand more succinctly complex avian parasite-vector-relations. The lack of vector competence trials may be attributed to the difficulty of obtaining gametocytes for the majority of Plasmodium species and lineages. To conduct avian malaria infectivity assays for those Plasmodium spp. and lineages that are refractory to in vitro cultivation, it is necessary to obtain and preserve for short periods sufficient viable merozoites to infect naïve donor birds to be used as gametocyte donors to infect mosquitoes...
March 11, 2016: Malaria Journal
https://www.readbyqxmd.com/read/26966916/three-dimensional-alginate-bead-culture-of-human-pituitary-adenoma-cells
#19
Dulce Avila-Rodríguez, Karina Paisano-Cerón, Irene Valdovinos-Ramírez, Carmen Solano-Agama, Alma Ortiz-Plata, María E Mendoza-Garrido
A three-dimensional culture method is described in which primary pituitary adenoma cells are grown in alginate beads. Alginate is a polymer derived from brown sea algae. Briefly, the tumor tissue is cut into small pieces and submitted to an enzymatic digestion with collagenase and trypsin. Next, a cell suspension is obtained. The tumor cell suspension is mixed with 1.2% sodium alginate and dropped into a CaCl2 solution, and the alginate/cell suspension is gelled on contact with the CaCl2 to form spherical beads...
February 18, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26963496/electrophoretic-separation-of-single-particles-using-nanoscale-thermoplastic-columns
#20
Kumuditha M Weerakoon-Ratnayake, Franklin I Uba, Nyoté J Oliver-Calixte, Steven A Soper
Phenomena associated with microscale electrophoresis separations cannot, in many cases, be applied to the nanoscale. Thus, understanding the electrophoretic characteristics associated with the nanoscale will help formulate relevant strategies that can optimize the performance of separations carried out on columns with at least one dimension below 150 nm. Electric double layer (EDL) overlap, diffusion, and adsorption/desorption properties and/or dielectrophoretic effects giving rise to stick/slip motion are some of the processes that can play a role in determining the efficiency of nanoscale electrophoretic separations...
April 5, 2016: Analytical Chemistry
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