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https://www.readbyqxmd.com/read/28098909/biology-and-function-of-glypican-3-as-a-candidate-for-early-cancerous-transformation-of-hepatocytes-in-hepatocellular-carcinoma-review
#1
Mauro Montalbano, Jeremias Georgiadis, Ashlyn L Masterson, Joshua T McGuire, Janika Prajapati, Ali Shirafkan, Cristiana Rastellini, Luca Cicalese
Glypican-3 (GPC-3), a transmembrane heparan sulfate proteoglycan (HSPG), has recently been investigated as a player in tissue-dependent cellular signaling, specifically as a regulator of growth. Noteworthy, the regulatory protein has been implicated in both stimulatory and inhibitory pathways involving cell growth. Initially, GPC-3 was thought to act as a cell cycle regulator, as a loss-of-function mutation in the gene caused a hyper-proliferative state known as Simpson-Golabi-Behmel (SGB) overgrowth syndrome...
January 18, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098406/contemporary-migration-patterns-in-the-prevalence-of-helicobacter-pylori-infection-a-systematic-review
#2
REVIEW
Samantha Morais, Ana Rute Costa, Ana Ferro, Nuno Lunet, Bárbara Peleteiro
BACKGROUND: A rapid growth in the number of international migrants over the past years has occurred with most traveling to more affluent settings. As Helicobacter pylori infects over half of the adult population and its prevalence is higher in developing countries, understanding the prevalence of infection in migrants can provide insight into future trends in the burden and management of infection. We aimed to describe the prevalence of H. pylori among migrants through a systematic literature review...
January 18, 2017: Helicobacter
https://www.readbyqxmd.com/read/28098342/the-evolution-of-rgs-proteins-as-drug-targets-20%C3%A2-years-in-the-making-iuphar-review-x
#3
REVIEW
B Sjögren
Regulators of G protein signaling (RGS) proteins are celebrating the 20(th) anniversary of their discovery. The unveiling of this new family of negative regulators of G protein signaling in the mid-1990's solved a persistent conundrum in the G protein signaling field, in which the rate of deactivation of signaling cascades in vivo could not be replicated in exogenous systems. Since then, there has been tremendous advancement in the knowledge of RGS protein structure, function, regulation and their role as novel drug targets...
January 18, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28098107/knowledge-and-attitude-towards-organ-donation-among-adult-population-in-al-kharj-saudi-arabia
#4
Sandeep Agrawal, Saud Binsaleem, Mohammed Al-Homrani, Abdullaziz Al-Juhayim, Abdullah Al-Harbi
Organ transplantation is a lifesaving treatment for patients with end-stage organ failure. Despite the advanced medical science and technology, shortage of organs had led to a growing gap between the demand for organs and the number of donors. With a limited number of studies on the subject and based on those findings, the public knowledge and attitudes must be assessed to understand more clearly that why many people are opposing donating their organs in Saudi Arabia. The objective of our study was to assess the knowledge and attitude of the adult population toward organ donation in Saudi Arabia...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28097814/detection-and-molecular-characterization-of-foot-and-mouth-disease-viruses-from-outbreaks-in-some-states-of-northern-nigeria-2013-2015
#5
D O Ehizibolo, A Haegeman, A R De Vleeschauwer, J U Umoh, H M Kazeem, E C Okolocha, K De Clercq, S Van Borm
Control measures for foot and mouth disease (FMD) in Nigeria have not been implemented due to the absence of locally produced vaccines and risk-based analysis resulting from insufficient data on the circulating FMD virus (FMDV) serotypes/strains. In 2013-2015, blood and epithelial samples were collected from reported FMD outbreaks in four states (Kaduna, Kwara, Plateau and Bauchi) in northern Nigeria. FMDV non-structural protein (NSP) seroprevalence for the outbreaks was estimated at 80% (72 of 90) and 70% (131 of 188) post-outbreak...
January 17, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28096740/unanswered-clinical-questions-a-survey-of-specialists-and-primary-care-providers
#6
Ellen Brassil, Bridget Gunn, Anant M Shenoy, Rebecca Blanchard
OBJECTIVE: With the myriad of cases presented to clinicians every day at our integrated academic health system, clinical questions are bound to arise. Clinicians need to recognize these knowledge gaps and act on them. However, for many reasons, clinicians might not seek answers to these questions. Our goal was to investigate the rationale and process behind these unanswered clinical questions. Subsequently, we explored the use of biomedical information resources among specialists and primary care providers and identified ways to promote more informed clinical decision making...
January 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28096447/pbp1b-glycosyltransferase-and-transpeptidase-activities-play-different-essential-roles-during-the-de-novo-regeneration-of-rod-shaped-morphology-in-escherichia-coli
#7
Dev K Ranjit, Matthew A Jorgenson, Kevin D Young
: Peptidoglycan is a vital component of nearly all cell wall-bearing bacteria and is a valuable target for antibacterial therapy. However, despite decades of work, there remain important gaps in understanding how this macromolecule is synthesized and molded into a three-dimensional structure that imparts specific morphologies to individual cells. Here, we investigate the particularly enigmatic area of how peptidoglycan is synthesized and shaped during the first stages of creating cell shape de novo, that is, in the absence of a pre-existing template...
January 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28096409/field-scale-experiments-reveal-persistent-yield-gaps-in-low-input-and-organic-cropping-systems
#8
Alexandra N Kravchenko, Sieglinde S Snapp, G Philip Robertson
Knowledge of production-system performance is largely based on observations at the experimental plot scale. Although yield gaps between plot-scale and field-scale research are widely acknowledged, their extent and persistence have not been experimentally examined in a systematic manner. At a site in southwest Michigan, we conducted a 6-y experiment to test the accuracy with which plot-scale crop-yield results can inform field-scale conclusions. We compared conventional versus alternative, that is, reduced-input and biologically based-organic, management practices for a corn-soybean-wheat rotation in a randomized complete block-design experiment, using 27 commercial-size agricultural fields...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096124/nutritional-considerations-for-healthy-aging-and-reduction-in-age-related-chronic-disease
#9
REVIEW
Julie Shlisky, David E Bloom, Amy R Beaudreault, Katherine L Tucker, Heather H Keller, Yvonne Freund-Levi, Roger A Fielding, Feon W Cheng, Gordon L Jensen, Dayong Wu, Simin N Meydani
A projected doubling in the global population of people aged ≥60 y by the year 2050 has major health and economic implications, especially in developing regions. Burdens of unhealthy aging associated with chronic noncommunicable and other age-related diseases may be largely preventable with lifestyle modification, including diet. However, as adults age they become at risk of "nutritional frailty," which can compromise their ability to meet nutritional requirements at a time when specific nutrient needs may be high...
January 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28096017/a-survey-of-skin-to-skin-contact-with-perinatal-nurses
#10
Dorothy Vittner, Xiaomei Cong, Susan M Ludington-Hoe, Jacqueline M McGrath
OBJECTIVE: This study explored perinatal nurses' knowledge, attitudes and practices of SSC, to identify knowledge-practice gaps. STUDY DESIGN: A descriptive cross-sectional survey design was completed by 101 perinatal nurses. Descriptive statistics and ordered logistical regression were used to describe and compare nurses' responses. RESULTS: The participants strongly agreed that it is nurses' responsibility to advocate for SSC. Significant differences (p<0...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28095901/risk-assessment-tools-to-predict-location-of-discharge-and-need-for-supportive-services-for-medical-patients-after-discharge-from-hospital-a-systematic-review-protocol
#11
Daniel M Kobewka, Daniel McIsaac, Michaël Chassé, Kednapa Thavorn, Sunita Mulpuru, Luke T Lavallée, Shane English, Justin Presseau, Alan J Forster
BACKGROUND: Patients who are discharged from hospital after an acute medical illness often have impaired function that prevents them from returning to their previous place of residence. Assessing each patient's post-discharge needs takes time and resources but is important in order to reduce unplanned readmissions and adverse events post-discharge. METHODS/DESIGN: We will conduct a systematic review to synthesize the evidence on prognostic models and their reported accuracy in predicting the location of discharge after a medical admission to an acute care hospital...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28095885/symptoms-of-attention-deficit-hyperactivity-disorder-adhd-among-adult-eating-disorder-patients
#12
Nils Erik Svedlund, Claes Norring, Ylva Ginsberg, Yvonne von Hausswolff-Juhlin
BACKGROUND: Very little is known about the prevalence of ADHD symptoms in Bulimia Nervosa and Binge Eating Disorder and even less in other eating disorders. This knowledge gap is of clinical importance since stimulant treatment is proven effective in Binge Eating Disorder and discussed as a treatment possibility for Bulimia Nervosa. The objective of this study was to explore the prevalence and types of self-reported ADHD symptoms in an unselected group of eating disorder patients assessed in a specialized eating disorder clinic...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28095278/awareness-of-hiv-transmission-risks-and-determinants-of-sexual-behaviour-descriptive-and-multivariate-analyses-among-german-nursing-students
#13
Carolin Jacob, Katharina von Lindeman, Jörg Klewer, Joachim Kugler
AIM: Nursing students play a crucial role in sexual health education. Evidence suggests, however, that nursing students had several gaps in their knowledge of HIV transmission. This study investigates how nursing students in Germany assess the potential risks of spreading HIV in defined situations and which factors influence the self-expressed sexual behaviour patterns of these students. METHODS: A standardized anonymous questionnaire was administered to a sample (N=617) of nursing students in 2008 and 2013...
December 2016: Central European Journal of Public Health
https://www.readbyqxmd.com/read/28094990/bridging-the-gap-between-dielectric-nanophotonics-and-the-visible-regime-with-effectively-lossless-gap-antennas
#14
Javier Cambiasso, Gustavo Grinblat, Yi Li, Aliaksandra Rakovich, Emiliano Cortés, Stefan A Maier
We present all-dielectric gallium phosphide (GaP) nanoantennas as an efficient nanophotonic platform for surface-enhanced second harmonic generation (SHG) and fluorescence (SEF), showing negligible losses in the visible range. Employing single GaP nanodisks, we observe an increase of more than three orders of magnitude in the SHG signal in comparison with the bulk. This constitutes an SHG efficiency as large as 0.0002%, which is, to the best of our knowledge, the highest yet achieved value produced by a single nano-object in the optical region...
January 17, 2017: Nano Letters
https://www.readbyqxmd.com/read/28094787/a-dataset-of-human-decision-making-in-teamwork-management
#15
Han Yu, Zhiqi Shen, Chunyan Miao, Cyril Leung, Yiqiang Chen, Simon Fauvel, Jun Lin, Lizhen Cui, Zhengxiang Pan, Qiang Yang
Today, most endeavours require teamwork by people with diverse skills and characteristics. In managing teamwork, decisions are often made under uncertainty and resource constraints. The strategies and the effectiveness of the strategies different people adopt to manage teamwork under different situations have not yet been fully explored, partially due to a lack of detailed large-scale data. In this paper, we describe a multi-faceted large-scale dataset to bridge this gap. It is derived from a game simulating complex project management processes...
January 17, 2017: Scientific Data
https://www.readbyqxmd.com/read/28093730/tumor-necrosis-factor-alpha-gene-promoter-238g-a-polymorphism-increases-the-risk-of-psoriasis-vulgaris-in-indian-patients
#16
Deepa Rajesh, Rajesh Gurumurthy, A V Moideen Kutty, Sharath Balakrishna
BACKGROUND: Tumor necrosis factor alpha (TNFα) gene -238G/A polymorphism (rs361525) is associated with psoriasis in several populations worldwide. To the best of our knowledge, there is no information about this polymorphism in Indian psoriatic patients. This study was undertaken to fill the gap in knowledge. METHODS: This case-control study involved 72 patients with psoriasis vulgaris (PsV) and 72 age and gender matched healthy individuals. TNFα -238G/A polymorphism was genotyped by PCR-RFLP method...
January 17, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28092359/lysine-relay-mechanism-coordinates-intermediate-transfer-in-vitamin-b6-biosynthesis
#17
Matthew J Rodrigues, Volker Windeisen, Yang Zhang, Gabriela Guédez, Stefan Weber, Marco Strohmeier, Jeremiah W Hanes, Antoine Royant, Gwyndaf Evans, Irmgard Sinning, Steven E Ealick, Tadhg P Begley, Ivo Tews
Substrate channeling has emerged as a common mechanism for enzymatic intermediate transfer. A conspicuous gap in knowledge concerns the use of covalent lysine imines in the transfer of carbonyl-group-containing intermediates, despite their wideuse in enzymatic catalysis. Here we show how imine chemistry operates in the transfer of covalent intermediates in pyridoxal 5'-phosphate biosynthesis by the Arabidopsis thaliana enzyme Pdx1. An initial ribose 5-phosphate lysine imine is converted to the chromophoric I320 intermediate, simultaneously bound to two lysine residues and partially vacating the active site, which creates space for glyceraldehyde 3-phosphate to bind...
January 16, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28092287/current-and-future-management-of-the-young-child-with-early-onset-wheezing
#18
Allison J Burbank, Stanley J Szefler
PURPOSE OF REVIEW: In this review, we discuss current thinking in relation to available guidelines for the care of preschool-aged children with recurrent wheezing, while highlighting the gaps in our knowledge and discussing changes that could occur over the next 5 years. RECENT FINDINGS: The Asthma Predictive Index as well as allergen-specific IgE, peripheral eosinophil count and exhaled nitric oxide are perhaps underutilized sources of information that can assist in predicting progression to asthma and response to therapies...
January 13, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28092207/healthcare-burden-of-depression-in-adults-with-arthritis
#19
Usha Sambamoorthi, Drishti Shah, Xiaohui Zhao
Arthritis and depression are two of the top disabling conditions. When arthritis and depression exist in the same individual, they can interact with each other negatively and pose a significant healthcare burden on the patients, their families, payers, healthcare systems, and society as a whole. Areas covered: The primary objective of this review is to summarize, identify knowledge gaps and discuss the challenges in estimating the healthcare burden of depression among individuals with arthritis. Electronic literature searches were performed on PubMed, Embase, EBSCOhost, Scopus, the Cochrane Library, and Google Scholar to identify relevant studies...
January 16, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28090288/expression-profiling-elucidates-a-molecular-gene-signature-for-pulmonary-hypertension-in-sarcoidosis
#20
Sunit Singla, Tong Zhou, Kamran Javaid, Taimur Abbasi, Nancy Casanova, Wei Zhang, Shwu-Fan Ma, Michael S Wade, Imre Noth, Nadera J Sweiss, Joe G N Garcia, Roberto F Machado
Pulmonary hypertension (PH), when it complicates sarcoidosis, carries a poor prognosis, in part because it is difficult to detect early in patients with worsening respiratory symptoms. Pathogenesis of sarcoidosis occurs via incompletely characterized mechanisms that are distinct from the mechanisms of pulmonary vascular remodeling well known to occur in conjunction with other chronic lung diseases. To address the need for a biomarker to aid in early detection as well as the gap in knowledge regarding the mechanisms of PH in sarcoidosis, we used genome-wide peripheral blood gene expression analysis and identified an 18-gene signature capable of distinguishing sarcoidosis patients with PH (n = 8), sarcoidosis patients without PH (n = 17), and healthy controls (n = 45)...
December 2016: Pulmonary Circulation
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