Feng Lyu, Shi-Yu Shang, Xian-Shu Gao, Ming-Wei Ma, Mu Xie, Xue-Ying Ren, Ming-Zhu Liu, Jia-Yan Chen, Shan-Shi Li, Lei Huang
Prostate cancer (PCa) is a critical global public health issue with its incidence on the rise. Radiation therapy holds a primary role in PCa treatment; however, radiation resistance has become increasingly challenging as we uncover more about PCa's pathogenesis. Our review aims to investigate the multifaceted mechanisms underlying radiation therapy resistance in PCa. Specifically, we will examine how various factors, such as cell cycle regulation, DNA damage repair, hypoxic conditions, oxidative stress, testosterone levels, epithelial-mesenchymal transition, and tumor stem cells, contribute to radiation therapy resistance...
June 3, 2023: Biomedicines