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Multiple sclerosis and exercise

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https://www.readbyqxmd.com/read/29224960/persons-with-secondary-progressive-and-relapsing-remitting-multiple-sclerosis-reveal-different-responses-of-tryptophan-metabolism-to-acute-endurance-exercise-and-training
#1
Jens Bansi, Christina Koliamitra, Wilhelm Bloch, Niklas Joisten, Alexander Schenk, Matthew Watson, Jan Kool, Dawn Langdon, Ulrik Dalgas, Jürg Kesselring, Philipp Zimmer
Disturbances in Tryptophan metabolism play a crucial role in multiple sclerosis (MS). Exercise is suspected to counteract the progress of MS and its side effects. Current research suggests alterations of Tryptophan metabolism in healthy individuals in response to exercise. We investigated the influence of acute aerobic exercise and training on Tryptophan metabolism in 57 inpatients with relapsing remitting ((RRMS) n=33) and secondary progressive ((SPMS) n=24) MS. Serotonin increased after training, whereas the kynurenine pathway was only activated in persons with RRMS...
December 6, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/29181199/the-effects-of-aerobic-exercise-on-the-recovery-of-walking-ability-and-neuroplasticity-in-people-with-multiple-sclerosis-a-systematic-review-of-animal-and-clinical-studies
#2
REVIEW
Augustine Joshua Devasahayam, Matthew Bruce Downer, Michelle Ploughman
Introduction: Walking is of high priority for people with multiple sclerosis (PwMS). It remains unclear whether aerobic exercise can improve walking ability and upregulate neurotrophins. This review aims to consolidate evidence to develop optimal aerobic training parameters to enhance walking outcomes and neuroplasticity in PwMS. Methods: Clinical studies examining aerobic exercise for ≥3 weeks, having outcomes on walking with or without neurotrophic markers, were included...
2017: Multiple Sclerosis International
https://www.readbyqxmd.com/read/29163185/orthostatic-intolerance-in-older-persons-etiology-and-countermeasures
#3
REVIEW
Nandu Goswami, Andrew P Blaber, Helmut Hinghofer-Szalkay, Jean-Pierre Montani
Orthostatic challenge produced by upright posture may lead to syncope if the cardiovascular system is unable to maintain adequate brain perfusion. This review outlines orthostatic intolerance related to the aging process, long-term bedrest confinement, drugs, and disease. Aging-associated illness or injury due to falls often leads to hospitalization. Older patients spend up to 83% of hospital admission lying in bed and thus the consequences of bedrest confinement such as physiological deconditioning, functional decline, and orthostatic intolerance represent a central challenge in the care of the vulnerable older population...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29157400/advanced-symptom-management-in-multiple-sclerosis
#4
REVIEW
Elizabeth Crabtree-Hartman
Meaningful symptom management can have a profound impact on quality of life. It can challenge time parameters during clinic, and therefore thought should be given to strategies that can improve efficiency and thereby make the undertaking more tenable. For any given symptom, the building blocks of care, such as vitamin D status, exercise/physical therapy, nutrition, and stress management, and ensuring disease-modifying therapy coverage, should be maximized. For each symptom, there are pharmacologic and nonpharmacologic interventions...
February 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/29143590/exercise-therapy-in-multiple-sclerosis-and-its-effects-on-function-and-the-brain
#5
Ulrik Dalgas
Exercise therapy is a promising nonpharmacological therapy in people with multiple sclerosis (MS). Although exercise training may induce a transient worsening of symptoms in some MS patients, it is generally considered safe and does not increase the risk of relapses. Exercise training can lead to clinically relevant improvements in physical function, but should be considered an adjunct to specific task-based training. Exercise has also shown positive effects on the brain, including improvements in brain volume and cognition...
November 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29140896/cold-water-ingestion-improves-exercise-tolerance-of-heat-sensitive-people-with-ms
#6
Georgia K Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L Davis, Ollie Jay
PURPOSE: Heat intolerance commonly affects the exercise capacity of people with multiple sclerosis (MS) during bouts of hot weather. Cold-water ingestion is a simple cooling strategy but its efficacy for prolonging exercise capacity with MS remains undetermined. We sought to identify whether cold-water ingestion blunts exercise-induced rises in body temperature and improves exercise tolerance in heat-sensitive individuals with MS. METHODS: On two separate occasions, 20 participants (10 relapsing-remitting MS (EDSS: 1-5); 10 age-matched healthy controls (CON)) cycled at ~40% VO2max at 30°C, 30%RH until volitional exhaustion (or a maximum of 60 min)...
November 15, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29128525/respiratory-rehabilitation-in-multiple-sclerosis-a-narrative-review-of-rehabilitation-techniques
#7
REVIEW
J Levy, H Prigent, D Bensmail
BACKGROUND: Respiratory disorders in multiple sclerosis (MS) are an important issue. They can occur early during the course of the disease, are associated with the neurological impairment, and can lead to pneumonia and respiratory failure, which are the main causes of death in advanced MS. Prevailing impaired expiratory muscles and cough abilities has been demonstrated in this population and might constitute a specific target for rehabilitation interventions. However, international guidelines lack recommendations regarding respiratory rehabilitation in MS...
November 8, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29113572/effects-of-an-individual-12-week-community-located-start-to-run-program-on-physical-capacity-walking-fatigue-cognitive-function-brain-volumes-and-structures-in-persons-with-multiple-sclerosis
#8
Peter Feys, Lousin Moumdjian, Florian Van Halewyck, Inez Wens, Bert O Eijnde, Bart Van Wijmeersch, Veronica Popescu, Paul Van Asch
BACKGROUND: Exercise therapy studies in persons with multiple sclerosis (pwMS) primarily focused on motor outcomes in mid disease stage, while cognitive function and neural correlates were only limitedly addressed. OBJECTIVES: This pragmatic randomized controlled study investigated the effects of a remotely supervised community-located "start-to-run" program on physical and cognitive function, fatigue, quality of life, brain volume, and connectivity. METHOD: In all, 42 pwMS were randomized to either experimental (EXP) or waiting list control (WLC) group...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29111839/the-interpretation-of-physical-activity-exercise-and-sedentary-behaviours-by-persons-with-multiple-sclerosis
#9
Dominique Kinnett-Hopkins, Yvonne Learmonth, Elizabeth Hubbard, Lara Pilutti, Sarah Roberts, Jason Fanning, Thomas Wójcicki, Edward McAuley, Robert Motl
OBJECTIVES: This study adopted a qualitative research design with directed content analysis and examined the interpretations of physical activity, exercise, and sedentary behaviour by persons with multiple sclerosis. METHODS: Fifty three persons with multiple sclerosis who were enrolled in an exercise trial took part in semi-structured interviews regarding personal interpretations of physical activity, exercise, and sedentary behaviours. RESULTS: Forty three percent of participants indicated a consistent understanding of physical activity, 42% of participants indicated a consistent understanding of exercise, and 83% of participants indicated a consistent understanding of sedentary behaviour with the standard definitions...
November 7, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29108826/physical-activity-and-autoimmune-diseases-get-moving-and-manage-the-disease
#10
REVIEW
Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Micheal Lichtbroun, Howard Amital, Yehuda Shoenfeld
Physical activity, by definition, is any skeletal muscle body movement that results in energy expenditure. In the last few decades, a plethora of scientific evidences have accumulated and confirmed the beneficial role of physical activity as a modifiable risk factor for a wide variety of chronic diseases including cardiovascular diseases (CVDs), diabetes mellitus and cancer, among others. Autoimmune diseases are a heterogeneous group of chronic diseases, which occur secondary to loss of self-antigen tolerance...
November 3, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29089214/examining-the-roles-of-self-compassion-and-resilience-on-health-related-quality-of-life-for-individuals-with-multiple-sclerosis
#11
Mara Nery-Hurwit, Joonkoo Yun, Vicki Ebbeck
BACKGROUND: There are over 400,000 individuals living with Multiple Sclerosis (MS) in the U.S. These individuals experience unpredictable relapses of disabling conditions and poorer quality of life than the general population. Recent literature suggests self-compassion and resilience may improve wellness in this population. OBJECTIVE: The purpose of this study was to examine the roles of self-compassion and resilience on perceived health-related quality of life for individuals with Multiple Sclerosis (MS) using mediation analysis...
October 23, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/29076760/aspirin-is-an-effective-pretreatment-for-exercise-in-multiple-sclerosis-a-double-blind-randomized-controlled-pilot-trial
#12
Victoria M Leavitt, Adam R Blanchard, Chu-Yueh Guo, Eva Gelernt, James F Sumowski, Joel Stein
Exercise benefits multiple sclerosis (MS) patients, but exercise-induced overheating is a deterrent for many. We conducted a double-blind crossover-design placebo-controlled pilot of aspirin to increase time-to-exhaustion (TTE) and reduce exercise-induced body temperature increase. A total of 12 patients participated. At enrollment, 8 of 12 reported heat sensitivity during exercise. After 650 mg of aspirin or placebo, participants performed lower body cycle ergometer exercise test. TTE increased after aspirin compared to placebo: t(11) = 2...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29057668/modeling-subjective-well-being-in-individuals-with-chronic-pain-and-a-physical-disability-the-role-of-pain-control-and-pain-catastrophizing
#13
Angela Furrer, Gisela Michel, Alexandra L Terrill, Mark P Jensen, Rachel Müller
PURPOSE: To investigate the associations between subjective well-being and pain intensity, pain interference, and depression in individuals with physical disabilities. We hypothesized that (1) pain control and (2) pain catastrophizing mediate the effects of subjective well-being on pain intensity, pain interference, and depression. METHODS: Analyses of cross-sectional data from 96 individuals diagnosed with spinal cord injury, multiple sclerosis, neuromuscular disease, or post-polio syndrome, with average pain intensity of ≥4 (0-10) on at least half the days in the past month...
October 23, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29055463/improvement-of-postural-control-in-individuals-with-multiple-sclerosis-after-a-single-session-of-ball-throwing-exercise
#14
Alexander S Aruin, Mohan Ganesan, Yunju Lee
BACKGROUND: Deficit in balance control is a common and often an initial disabling symptom of multiple sclerosis (MS). We investigated the role of short-term training in improvement of anticipatory postural adjustments (APAs) and its effect on subsequent control of posture in individuals with MS. METHODS: A pre-post feasibility study involved eight individuals with relapsing-remitting MS who participated in the laboratory tests before and after a single training session consisting of throwing a medicine ball...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29055449/successful-long-term-management-of-spasticity-in-patients-with-multiple-sclerosis-using-a-software-application-app-a-pilot-study
#15
Rainer Ehling, Michael Edlinger, Kay Hermann, Kerstin Dröge, Yvonne Seidinger, Ursula Miller, Hannes Franz Alber, Christian Brenneis
BACKGROUND: Spasticity is a very common syndrome in patients with multiple sclerosis (pwMS), but available treatments lead to sufficient symptom control only in one third. OBJECTIVE: To investigate the impact of an individualized training program on improving spasticity in a prospective pilot trial in pwMS suffering from moderate spasticity (defined as ≥ 4 on a normative rating scale; NRS). METHODS: PwMS were familiarized with predefined exercises targeting spasticity while undergoing inpatient rehabilitation (IR)...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29036843/aberrant-peak-lactate-response-in-ms
#16
Kathrin Schlüter, Josephina Maier, Stefan Patra, Stefan M Gold, Christoph Heesen, Karl-Heinz Schulz
BACKGROUND: The peak blood lactate response to an exhaustive exercise test in a number of chronic conditions has been shown to differ from that seen in healthy, untrained individuals. However, this has not been investigated for patients with multiple sclerosis (MS). OBJECTIVE: The main objective was to determine and compare the peak blood lactate response to exercise and the maximal workload between two groups of MS patients with different illness severity. METHODS: Twenty-five patients with a relapsing-remitting disease course (Group RR) and 41 patients with a secondary- or primary chronic progressive disease course (group CP) performed an exhaustive incremental bicycle ergometry...
October 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/29025830/randomised-controlled-pilot-trial-of-an-exercise-plus-behaviour-change-intervention-in-people-with-multiple-sclerosis-the-step-it-up-study
#17
Sara Hayes, Marcin Kacper Uszynski, Robert W Motl, Stephen Gallagher, Aidan Larkin, John Newell, Carl Scarrott, Susan Coote
OBJECTIVE: To investigate feasibility of multiple sclerosis (MS) exercise guidelines for inactive people with MS (PwMS) and to examine preliminary efficacy for walking. To investigate effect of augmenting that intervention with education based on social cognitive theory (SCT). DESIGN: Pilot multicentre, double-blind, randomised, parallel, controlled trial. SETTING: Community-delivered programme. PARTICIPANTS: Sixty-five physically inactive PwMS walked independently, scored 0-3 on the Patient Determined Disease Steps Scale, had no MS relapse or change in MS medication in 12 weeks...
October 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28991714/the-pharmacological-and-non-pharmacological-interventions-for-the-management-of-fatigue-related-multiple-sclerosis
#18
REVIEW
Philippa Miller, Andrew Soundy
AIM: The clinical aim was to provide up-to-date evidence-based recommendations for the treatment of MS-related fatigue (MSRF). The scientific aim was to prioritise topics for future randomised clinical trials with sufficient power. METHODS: A systematic search of review based research that considered MSRF in adults (18years and over) was undertaken in May 2016. Data from reviews was extracted, critically appraised and synthesised using four specific techniques. RESULTS: A total of 24 reviews were identified (17 non-pharmacological, 5 pharmacological, 2 combining both), which contained 339 studies on interventions deigned to improve MSRF...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28991096/evaluation-of-intervention-fidelity-in-a-multisite-clinical-trial-in-persons-with-multiple-sclerosis
#19
Janet D Morrison, Heather Becker, Alexa K Stuifbergen
BACKGROUND: Careful consideration of intervention fidelity is critical to establishing the validity and reliability of research findings, yet such reports are often lacking in the research literature. It is imperative that intervention fidelity be methodically evaluated and reported to promote the translation of effective interventions into sound evidence-based practice. PURPOSE: The purpose of this article is to explore strategies used to promote intervention fidelity, incorporating examples from a multisite clinical trial, that illustrate the National Institutes of Health Behavior Change Consortium's 5 domains for recommended treatment practices: (1) study design, (2) facilitator training, (3) intervention delivery, (4) intervention receipt, and (5) intervention enactment...
December 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28949284/aerobic-exercise-cognitive-behavioural-therapy-and-energy-conservation-management-for-multiple-sclerosis-ms-fatigue-are-three-trials-better-than-one
#20
Rona Moss-Morris, Sam Norton
No abstract text is available yet for this article.
October 2017: Multiple Sclerosis: Clinical and Laboratory Research
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