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Multiple sclerosis and exercise

Lilian Assunção Felippe, Pedro Rippel Salgado, Diego de Souza Silvestre, Suhaila Mahmoud Smaili Santos, Gustavo Christofoletti
OBJECTIVE: To investigate the effects of a 6-month exercise program on cognition and mobility in participants with multiple sclerosis. DESIGN: Prospective, single blind, controlled clinical trial. SETTING: A community rehabilitation program within a large metropolitan health service. PARTICIPANTS: Twenty-eight patients with multiple sclerosis, referred for outpatient rehabilitation. INTERVENTIONS: Participants were allocated to one of two groups and undertook a cognitive-motor exercise program or monitoring (control group)...
June 21, 2018: American Journal of Physical Medicine & Rehabilitation
Kaitlynne Leclaire, Audrey Cecil, Allison LaRussa, Fiona Stuart, Christopher C Hemond, Brian C Healy, Tanuja Chitnis, Howard Weiner, Jeff Huffman, Bonnie I Glanz
Background: Positive psychology uses targeted activities to increase the frequency and intensity of positive emotional experiences. Positive psychology interventions that increase positive constructs may facilitate adjustment and improve well-being in patients with multiple sclerosis (MS). The primary goal of this study was to assess the feasibility and acceptability of a 5-week group positive psychology intervention for patients with MS. In addition, we examined the utility of the group intervention to increase positive psychological constructs and health-related quality of life (HRQOL)...
May 2018: International Journal of MS Care
Marcin Kacper Uszynski, Blathin Casey, Sara Hayes, Stephen Gallagher, Helen Purtill, Robert W Motl, Susan Coote
Background: There is a growing body of evidence that physical activity (PA) improves symptoms of multiple sclerosis (MS). Despite the benefits of PA, people with MS are relatively inactive compared with their healthy counterparts. This study investigated associations between social cognitive theory (SCT) constructs and energy expenditure (EE) as an objective measure of PA in a sample of inactive people with MS. Methods: Participants (n = 65) completed several questionnaires and were assessed using standardized outcome measures as part of a cross-sectional analysis of baseline data from a randomized controlled trial (Step it Up)...
May 2018: International Journal of MS Care
Motahare Mokhtarzade, Robert Motl, Raoof Negaresh, Philipp Zimmer, Mostafa Khodadoost, Julien S Baker, Darpan Patel, Nastaran Majdinasab, Rouholah Ranjbar
Blood-brain barrier (BBB) and neurotrophic factors seemingly have an important role in multiple sclerosis pathology. Physical activity may influence blood-brain barrier function and levels of neurotrophic factors, and such effects might be moderated by body weight status. This study investigated the effect of exercise training on markers of blood-brain barrier permeability and neurotrophic factors as a function of weight status in multiple sclerosis patients. Sixty three persons with relapsing remitting multiple sclerosis who were normal weight (n: 33) or overweight (n: 33) were randomly assigned into groups of exercise (normal weight training, n: 18; overweight training group, n: 18) or no exercise (normal weight control, n: 15; overweight control group, n: 15)...
May 31, 2018: Neuropeptides
Terry Wahls, Maria O Scott, Zaidoon Alshare, Linda Rubenstein, Warren Darling, Lucas Carr, Karen Smith, Catherine A Chenard, Nicholas LaRocca, Linda Snetselaar
BACKGROUND: Fatigue is one of the most disabling symptoms of multiple sclerosis (MS) and contributes to diminishing quality of life. Although currently available interventions have had limited success in relieving MS-related fatigue, clinically significant reductions in perceived fatigue severity have been reported in a multimodal intervention pilot study that included a Paleolithic diet in addition to stress reduction, exercise, and electrical muscle stimulation. An optimal dietary approach to reducing MS-related fatigue has not been identified...
June 4, 2018: Trials
James H Rimmer, Mohanraj Thirumalai, Hui-Ju Young, Dori Pekmezi, Tracy Tracy, Emily Riser, Tapan Mehta
Long-term exercise/rehabilitation is an integral component of the continual care for people with multiple sclerosis (MS). However, access to this care, which includes comprehensive exercise/rehabilitation services to people with MS, remains a significant challenge, especially in rural, low-income areas. Telerehabilitation, or what we refer to as teleexercise, can help fill service gaps for underserved MS populations in this region. This pragmatic, cluster randomized controlled effectiveness trial will compare a 12-week, 20 session complementary and alternative medicine (CAM) intervention composed of neurorehabilitative (functional) exercise, yoga and Pilates delivered at home, using pre-loaded tablets and Interactive Voice Response (IVR) system technology (TeleCAM), to the same intervention delivered in clinic by a therapist (DirectCAM)...
May 30, 2018: Contemporary Clinical Trials
Fatemeh Mosalanejad, Ardashir Afrasiabifar, Mohammad Zoladl
OBJECTIVE: To evaluate the combined effect of pelvic floor muscle exercise and mindfulness on sexual function in women with multiple sclerosis. DESIGN: It was a three-arm parallel randomized clinical trial study. SETTING: Outpatient clinic. SUBJECTS: Patients with multiple sclerosis. INTERVENTIONS: Participants in the intervention groups completed an eight-week program consisting of pelvic floor muscle exercise, mindfulness, and pelvic floor muscle exercise along with mindfulness...
May 1, 2018: Clinical Rehabilitation
Mohanraj Thirumalai, James H Rimmer, George Johnson, Jereme Wilroy, Hui-Ju Young, Tapan Mehta, Byron Lai
BACKGROUND: People with multiple sclerosis face varying levels of disability and symptoms, thus requiring highly trained therapists and/or exercise trainers to design personalized exercise programs. However, for people living in geographically isolated communities, access to such trained professionals can be challenging due to a number of barriers associated with cost, access to transportation, and travel distance. Generic mobile health exercise apps often fall short of what people with multiple sclerosis need to become physically active (ie, exercise content that has been adapted to accommodate a wide range of functional limitations)...
May 24, 2018: JMIR MHealth and UHealth
Mohammad Etoom, Yazan Khraiwesh, Francesco Lena, Mohannad Hawamdeh, Ziad Hawamdeh, Diego Centonze, Calogero Foti
OBJECTIVE: To examine the effectiveness of physiotherapy (PT) interventions on spasticity in people with multiple sclerosis (PwMS). DESIGN: A systematic search was performed using PRISMA guidance. Studies evaluate the effect of PT interventions on spasticity were included. PwMS, spasticity, disability and PT interventions characteristics were extracted in included studies. Level of evidence was synthesized by GRADE approach. Meta-analyses were performed by calculating Hedges g at 95% confidence interval...
May 22, 2018: American Journal of Physical Medicine & Rehabilitation
Lauren B Strober, Alexandra Becker, John J Randolph
Multiple sclerosis (MS) is a neurological condition associated with a wide variety of physical, cognitive, and mood-related symptoms. While disease-modifying treatment has been shown to reduce the severity and frequency of MS symptom relapses, engagement in certain daily activities holds promise as an adjunctive treatment to better manage disease sequelae. The present study sought to determine whether healthy nutritional choices, exercise, and social/intellectual engagement impacts functioning in individuals with MS...
July 2018: Applied Neuropsychology. Adult
Maryam Naghibzadeh, Rouhollah Ranjbar, Mohammad Reza Tabandeh, Abdolhamid Habibi
The aim of the present study was to investigate the effects of high-intensity interval training (HIIT) versus low-intensity continuous training (LICT) on transcriptional levels of neurotrophic factors and oligodendrocyte/microglia cell loss in a cuprizone (CP) induced animal model of demyelination. Male C57BL/6 mice were assigned to six groups: control (C), cuprizone-induced demyelination (CP), interval training (IT), continuous training (CT), IT plus CP (ITCP), and CT plus CP (CTCP). Training programs on the treadmill were performed for four weeks, and then demyelination was induced by feeding mice a diet containing 0...
May 18, 2018: International Journal of Sports Medicine
Jessica F Baird, Brian M Sandroff, Robert W Motl
Mobility disability is one of the most widespread and impactful consequences of multiple sclerosis (MS). Disease modifying drugs (DMDs) may delay the progression of disability over time; however, there is minimal evidence supporting the efficacy of DMDs for reversing mobility disability or restoring ambulatory function in persons with MS. Areas covered: This review outlines symptomatic pharmacologic and non-pharmacologic therapeutic approaches that target mobility disability with the goal of restoring and improving walking function...
May 17, 2018: Expert Review of Neurotherapeutics
Rachel Dennett, Hilary Gunn, Jennifer A Freeman
Background: Supporting people with multiple sclerosis (MS) to achieve and maintain recommended levels of physical activity is important but challenging. Web-based interventions are increasingly being used to deliver targeted exercise programs and promote physical activity. Purpose: The purpose of this study was to systematically review current evidence regarding the effectiveness and user experience of web-based interventions in increasing physical activity in people with MS...
May 15, 2018: Physical Therapy
E Sebastião, R W Motl
OBJECTIVE: This study examined body fatness and its association with cardiorespiratory fitness (CRF) in persons with multiple sclerosis (pwMS) accounting for disability status. MATERIALS AND METHODS: This study involved a secondary data analysis from a previous study of 62 pwMS. Body fatness was indirect measured as body mass index (BMI), and CRF was measured as peak oxygen consumption from an incremental exercise test with spirometry. Participants were allocated into 3 different groups based on established BMI categories (ie, normal, overweight, and obese), and data were analyzed using SPSS...
May 11, 2018: Acta Neurologica Scandinavica
Marcello Di Paolo, Antonietta Gigante, Marta Liberatori, Liborio Sardo, Paolo Marinelli, Marco Rossetti, Paolo Palange, Luigi Tubani, Edoardo Rosato
OBJECTIVES: Autonomic dysfunction (AD) in systemic sclerosis (SSc) was already confirmed through heart rate variability (HRV) analysis. Cardio-pulmonary exercise testing (CPET) is a useful tool in early detection of exercise tolerance in SSc patients. Aim of the study was to assess the relationships existing between AD and exercise tolerance. METHODS: Thirty-two [4 M, 28 F; median age: 47.5 (20-65) years] consecutive SSc patients were enrolled. All patients underwent pulmonary function testing, incremental symptom-limited CPET and twenty-four hours ECG Holter recording with HRV analysis in time and frequency domain...
May 4, 2018: Clinical and Experimental Rheumatology
Kimberly R Chapman, Jason R Anderson, Dayana Calvo, Brandon S Pollock, Jennifer Petersen, Hayden Gerhart, Angela Ridgel, Mary Beth Spitznagel
BACKGROUND: Despite the demonstrated benefits of exercise in multiple sclerosis (MS), this population shows low rates of physical activity. Understanding barriers to exercise in persons with MS is important. The current study examined the relationship between lifetime history of depression, current depressive symptoms, and aerobic endurance in persons with relapsing-remitting MS to determine whether depression might be one such barrier. METHODS: Thirty-one participants with relapsing-remitting MS self-reported current depressive symptoms and history of depression...
June 2018: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
Nastaran Majdinasab, Robert W Motl, Motahare Mokhtarzade, Philipp Zimmer, Rouholah Ranjbar, Charly Keytsman, Tom Cullen, Raoof Negaresh, Julien S Baker
OBJECTIVE: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). METHODS: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise...
May 2018: Complementary Therapies in Clinical Practice
Emerson Sebastião, Edward McAuley, Ryosuke Shigematsu, Robert W Motl
We propose a randomized controlled trial (RCT) examining the feasibility of square-stepping exercise (SSE) delivered as a home-based program for older adults with multiple sclerosis (MS). We will assess feasibility in the four domains of process, resources, management and scientific outcomes. The trial will recruit older adults (aged 60 years and older) with mild-to-moderate MS-related disability who will be randomized into intervention or attention control conditions. Participants will complete assessments before and after completion of the conditions delivered over a 12-week period...
September 2017: Contemporary Clinical Trials Communications
Whitney R D Duff, Justin W Andrushko, Doug W Renshaw, Philip D Chilibeck, Jonathan P Farthing, Jana Danielson, Charity D Evans
Background: Pilates is a series of exercises based on whole-body movement and may improve mobility in people with multiple sclerosis (MS). The purpose of this study was to determine the effect of Pilates on walking performance in people with MS. Methods: 30 individuals with MS who were not restricted to a wheelchair or scooter (Patient-Determined Disease Steps scale score <7) were randomized to receive Pilates (twice weekly) and massage therapy (once weekly) or once-weekly massage therapy only (control group)...
March 2018: International Journal of MS Care
Anna Caroline Marques Braga, Anabela Pinto, Susana Pinto, Mamede de Carvalho
Introduction: The efficacy of cardiopulmonary exercise testing (CPET) to determining exercise intensity has not been established in Amyotrophic Lateral Sclerosis (ALS). We studied this intervention. Methods: We included 48 ALS patients randomized in 2 groups: G1 ( n = 24), exercise intensity leveled by CPET; G2 ( n = 24), standard care limited by fatigue, during 6 months. ALS functional scale (ALSFRS-R) and forced vital capacity (FVC) were performed every 3 months; CPET was done at admission ( T 1) and 6 months later ( T 2)...
2018: Neurology Research International
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