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Benli Jia, Dongsheng Yu, Gang Yu, Yunsheng Cheng, Yang Wang, Xiaoqiang Yi, Xiaoping Li, Yong Wang
Hepatitis C virus (HCV) infection may finally lead to hepatocellular carcinoma (HCC), and also associated with insulin resistance (IR). Naringenin (NGEN), a flavonoid found in grapefruit, has anti-virus, anti-inflammation and insulin sensitization effects. In the present study we examined the effects of NGEN on HCV core protein (HCVCP) infection induced IR and investigated the mechanism involved. We found that NGEN ameliorated IR and glucose tolerance in HCVCP infected mice by increase the phosphorylation of Akt at both Ser473 and Thr308 site, and also inhibited the inflammation cytokine production and T-cell immune response...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Giovanni Fusco, Gero Göbel, Robertino Zanoni, Maria Paola Bracciale, Gabriele Favero, Franco Mazzei, Fred Lisdat
In this study, polythiophene copolymers have been used as modifier for electrode surfaces in order to allow the immobilization of active pyrroloquinoline quinone dependent glucose dehydrogenase (PQQ-GDH) and to simultaneously improve the direct electrical connection of the enzyme with the electrode. Polymer films are electrosynthesized in aqueous solution without the need of surfactants onto carbon nanotubes modified gold electrodes from mixtures of 3-thiopheneacetic acid (ThCH2 CO2 H) and 3-methoxythiophene (ThOCH3 ) using a potentiostatic pulse method...
April 7, 2018: Biosensors & Bioelectronics
Ji Wang, Tong Wu, Xiaobin Fang, Weihong Min, Zhennai Yang
A purified neutral exopolysaccharide (EPS) designated as EPS0142 was obtained from Lactobacillus plantarum JLK0142. EPS0142 consisted of glucose and galactose in an approximate molar ratio of 2.13:1.06 and had a molecular weight of 1.34 × 105  Da. The FT-IR spectrum showed that EPS0142 had a typical polysaccharide absorption pattern. 1 H NMR and 13 C NMR spectra analysis showed the presence of N-acetylated sugar residues. EPS0142 had no toxic effects on RAW 264.7 cells and significantly improved their phagocytic activity and NO secretion in vitro...
April 20, 2018: International Journal of Biological Macromolecules
I M Kenawy, M A Ismail, M A H Hafez, M A Hashem
The new ion-imprinted guanyl-modified cellulose (II.Gu-MC) was prepared for the separation and determination of Cu (II) ions in different real samples. Several techniques such as Fourier Transform Infrared (FT-IR), scanning electron microscope (SEM), thermal analysis, potentiograph and elemental analysis have been utilized for the characterization of II.Gu-MC. The adsorption behavior of the ion imprinted polymer (II.Gu-MC) was evaluated and compared to the non ion-imprinted polymer (NII.Gu-MC) at the optimum conditions...
April 20, 2018: International Journal of Biological Macromolecules
Milena Maria Moreira Guimarães, Dirceu Bartolomeu Greco, Allyson Nogueira Moreira, Nathalia Sernizon Guimarães, Cláudia Maria Vilas Freire, Bruna Guimarães Rolfs, Lucas José de Campos Machado
The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels...
April 20, 2018: Brazilian Journal of Infectious Diseases
J C López López, M Ballesteros Polo, M Sampere Valero, R Sacristán Nieto, S Alguacil García, A Ruiz Julian, E Santos Avila, S García Rubia, B López Costa, J M Martínez Martínez
INTRODUCTION: Different countries have shown an inverse relationship between unemployment rates (UR) and indicators of sickness absence during periods of economic recession. OBJECTIVE: To evaluate the relationship between indicators of sickness absence and unemployment in Spain during 2009-2015. METHODS: We obtained incidence and absenteeism rates of non-work related sickness absence (NWSA) from Social Security data, and UR from the National Institute of Statistics...
April 2018: Archivos de Prevención de Riesgos Laborales
Tian-Tian Zou, Chao Zhang, Yi-Fan Zhou, Yi-Jing Han, Jiao-Jiao Xiong, Xi-Xi Wu, Yong-Ping Chen, Ming-Hua Zheng
Lifestyle interventions remain the first-line therapy for nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate the individual impact of exercise and/or dietary interventions on the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), homeostasis model of assessment for insulin resistance index (HOMA-IR), and BMI. Randomized-controlled trials from patients diagnosed with NAFLD were included in the meta-analysis if they reported the associations between changes in ALT, AST, HOMA-IR, or BMI and types of lifestyle interventions...
April 20, 2018: European Journal of Gastroenterology & Hepatology
Atieh Modarresi, Mohsen Nafar, Zahra Sahraei, Jamshid Salamzadeh, Samira Chaibakhsh, Shadi Ziaie, Mahmoud Parvin, Yunes Panahi, Behzad Einollahi
CONTEXT: Acute kidney injury (AKI) is a common complication after kidney transplantation (KT), especially in recipients from deceased donors. Urinary neutrophil gelatinase-associated lipocalin (u-NGAL) is an early and sensitive marker of AKI after transplantation. OBJECTIVES: We assessed the renoprotective effect of N-acetylcysteine (NAC) on u-NGAL levels as an early prognostic marker of graft function immediately after transplantation. MATERIALS AND METHODS: A double-blind, randomized, placebo-controlled trial was conducted on 70 deceased-donor KT recipients ( www...
April 23, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Guillaume Falco, Nathanael Guigo, Luc Vincent, Nicolas Sbirrazzuoli
This work shows how furan ring-opening reactions were controlled by polymerization conditions to tune the cross-link density in biobased poly(furfuryl alcohol) (PFA). The influence of water and isopropyl alcohol (IPA) on the polymerization of furfuryl alcohol (FA), and particularly on furan ring-opening, was investigated by means of 13C NMR and FT-IR spectroscopy. Results indicated that formation of open structures were favored in presence of solvents thus leading to modification of thermo-mechanical properties compared to PFA cross-linked without solvent...
April 23, 2018: ChemSusChem
Arul Prakash Francis, Sneha Gurudevan, A Jayakrishnan
Polymannose (PM) having a weight-average molar mass (Mw ) of 30-53 kDa was synthesized by the polycondensation of mannose using phosphorous acid as the catalyst and characterized by various techniques such as NMR, IR, GPC and polarimetry. 2D NMR results confirmed the presence of (1→ 6)-linked α-D-mannose residues as backbone with O-3 and O-2 substituted linear or branched chains in PM. Amphotericin B (AmB) was conjugated to periodate-oxidized PM through Schiff's linkages at 20 wt% concentration. The AmB-PM conjugates were highly soluble in phosphate buffered saline (180-250 mg/mL), exhibited negligible hemolytic potential to human erythrocytes even at a concentration of 200 μg /mL (equivalent to ~ 40 μg/mL AmB) and were non-toxic to human embryonic kidney (HEK293T) cells even at a concentration of 250 μg/mL (equivalent to ~ 50 μg/mL AmB)...
April 23, 2018: Journal of Biomaterials Science. Polymer Edition
Min-Hong Jiang, Yue Hu, Lin Jiao, Pan Dong, Sheng Yin, Zhi-Min Zhao, De-Po Yang, Dong-Mei Wang
Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2-10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell line (IC50  = 23...
April 23, 2018: Journal of Asian Natural Products Research
M Masiá, S Padilla, J A García, J I Bernardino, A A Campins, V Asensi, F Gutiérrez
OBJECTIVES: Contemporary data from country-wide cohorts are needed to reveal trends in the occurrence of acute myocardial infarction (AMI) in people living with HIV (PLWH). We analysed time trends in the standardized incidence rate (sIR) of AMI in PLWH in Spain from 2004 to 2015, and compared them with trends in the general population. METHODS: A longitudinal study in a nationwide contemporary multicentre HIV-infected cohort was carried out. Data on all incident AMI events were collected, and age- and sex-standardized IRs calculated...
April 23, 2018: HIV Medicine
Hiromichi Ueno, Mitsuhiro Yoshimura, Kentaro Tanaka, Haruki Nishimura, Kazuaki Nishimura, Satomi Sonoda, Yasuhito Motojima, Reiko Saito, Takashi Maruyama, Tetsu Miyamoto, Ryota Serino, Masahito Tamura, Tatsushi Onaka, Yutaka Otsuji, Yoichi Ueta
Furosemide, which is used worldwide as a diuretic agent, inhibits sodium reabsorption in the Henle's loop, resulting in diuresis and natriuresis. Arginine vasopressin (AVP) is synthesized in the supraoptic nucleus (SON), paraventricular nucleus (PVN), and suprachiasmatic nucleus (SCN) of the hypothalamus. The synthesis AVP in the magnocellular neurons of SON and PVN physiologically regulated by plasma osmolality and blood volume and contributed water homeostasis by increasing water reabsorption in the collecting duct...
April 22, 2018: Journal of Neuroendocrinology
Sang Yeon Lee, Gowoon Shim, Jucheol Park, Hyungtak Seo
The tunable polaron effect of amorphous tungsten oxide on FTO substrates has been used to detect fluorine in the gas phase via photochemical and gasochromic reactions. By combining photochemical (UV exposure under an H2 atomsphere) and gasochromic (XeF2 exposure) reactions, the detection of gaseous fluorine using amorphous tungsten oxide is described. The effective hydrogenation of WO3 was achieved using UV/H2 exposure to prepare hydrogenated tungsten oxide (H-WO3-x) upon activating the strong polaron-coupling to infrared (IR) light to decrease IR transmission from 70 to 20% at 1000 nm wavelength...
April 23, 2018: Physical Chemistry Chemical Physics: PCCP
Olga V Yurchenko, Olga I Skiteva, Elena E Voronezhskaya, Vyacheslav A Dyachuk
Background: Bivalves comprise a large, highly diverse taxon of invertebrate species. Developmental studies of neurogenesis among species of Bivalvia are limited. Due to a lack of neurogenesis information, it is difficult to infer a ground pattern for Bivalvia. To provide more comprehensive morphogenetic data on bivalve molluscs and relationships among molluscan clades, we investigated neurogenesis in the Pacific oyster, Crassostrea gigas , from the appearance of the first sensory cells to the formation of the larval ganglionic nervous system by co-immunocytochemistry of the neuronal markers FMRFamide or 5-HT and vesicular acetylcholine transporter (VAChT)...
2018: Frontiers in Zoology
Andrea Ertani, Ornella Francioso, Anna Tinti, Michela Schiavon, Diego Pizzeghello, Serenella Nardi
Seaweed extracts can be employed as biostimulants during crop cultivation owing to their positive effects on plant performance. Therefore, in this study one extract from Laminaria (A) and five extracts from Ascophyllum nodosum (B-F) were assayed on maize ( Zea mays L.) plants supplied for 2 days with 0.5 mL L-1 of single products to evaluate their capacity to stimulate root growth and morphology, nutrition, and sugars accumulation. Firstly, extracts were chemically characterized via Fourier transform infrared (FT-IR) and FT-Raman spectroscopies, and their content in carbon, nitrogen, phenolic acids and hormones (indole-3-acetic acid, IAA, and Isopentenyladenosine, IPA) was quantified...
2018: Frontiers in Plant Science
Kelly N Z Fuller, Edwin R Miranda, John P Thyfault, Jill K Morris, Jacob M Haus
Although there is evidence for metabolic dysfunction and chronic inflammation in Alzheimer's disease (AD), circulating levels of soluble receptor for advanced glycation end products (sRAGE) and the receptor for advanced glycation end products (RAGE) ligand S100B have not been characterized. sRAGE is an important mediator in disease as it can act as a ligand decoy for RAGE and attenuate downstream inflammatory signaling. Cognitively healthy elderly and AD participants with and without type 2 diabetes ( n = 135) were stratified according to the clinical dementia rating (CDR; 0 = normal cognition (NC); ≥0...
2018: Mediators of Inflammation
Maryo Cenk Kohen, Sinan Tatlipinar, Alev Cumbul, Ünal Uslu
Purpose: To create a model of an ischemic retina with temporary ischemia and reperfusion (IR) and to examine the possible antiapoptotic and neurodegenerative effects of a vascular endothelial growth factor (VEGF) antagonist. Methods: Three groups were formed. Rats were subjected to continued ischemia for 45 min, and then reperfusion was allowed for 2 days. For the first group, ischemia was induced, but an anti-VEGF agent was not administered. For the second group, 2 days before ischemia, 0...
2018: Molecular Vision
Monpichar Srisa-Art, Scott D Noblitt, Amber T Krummel, Charles S Henry
Coupling infrared (IR) spectroscopy to microfluidic devices provides a powerful tool for characterizing complex chemical and biochemical reactions. Examples of microfluidic devices coupled with infrared spectroscopy have been limited, however, largely due to the difficulties associated with fabricating systems in common infrared transparent materials like CaF2 . Recent reports have shown that polydimethylsiloxane (PDMS) can be used as an IR transparent substrate when fabricated with thin layers. The use of soft lithography with PDMS expands the library of possible designs that can be achieved for IR measurements in microfluidics...
August 27, 2018: Analytica Chimica Acta
Åsmund Rinnan, Francesco Savorani, Søren Balling Engelsen
Interval based chemometric algorithms have proven to be very powerful for spectral alignments, spectral regressions and spectral classifications. The interval-based methods may not only improve the performance, but also reduce model complexity and enhance the spectral interpretation. Extended Canonical Variate Analysis (ECVA) is a powerful method for multiple group classifications of multivariate data and can easily be extended to an interval approach, iECVA. This study outlines the iECVA method and compares its performance to interval Partial Least Squares Discriminant Analysis (iPLS-DA) on three spectroscopic datasets from Nuclear Magnetic Resonance (NMR), Near Infrared (NIR) and Infrared (IR) spectroscopy, respectively...
August 27, 2018: Analytica Chimica Acta
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