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https://www.readbyqxmd.com/read/27933750/comparing-glucose-and-hemoglobin-a1c-diagnostic-tests-among-a-high-metabolic-risk-hispanic-population
#1
Mónica A Vega-Vázquez, Margarita Ramirez-Vick, Francisco J Muñoz-Torres, Loida A González-Rodríguez, Kaumudi Joshipura
AIMS: Compare HbA1c diagnostic tests for pre-diabetes and diabetes with plasma glucose criteria (PGC), and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS: Participants were recruited for the San Juan Overweight Adults Longitudinal Study (SOALS). Were primarily Hispanic (98%), without previously diagnosed diabetes, and aged 40-65 years. Participants classified as normal glycemic, pre-diabetes or diabetes based on baseline HbA1c and PGC, were compared with respect to baseline cardiometabolic factors...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27933686/risk-of-incident-mycobacterium-tuberculosis-infection-in-patients-with-inflammatory-bowel-disease-a-nationwide-population-based-study-in-south-korea
#2
S N Hong, H J Kim, K H Kim, S-J Han, I M Ahn, H S Ahn
BACKGROUND: The low incidence of Mycobacterium tuberculosis infection and lack of adequate controls have prevented researchers from estimating tuberculosis (TB) risk in inflammatory bowel disease (IBD) patients. AIM: To evaluate the risk of incident TB among IBD patients. METHODS: Using the 2011-2013 data of the South Korean National Health Insurance (NHI) system, we calculated the incidence rates (IRs), standardised incidence ratio (SIR) and number needed to screen (NNS) for incident TB in IBD patients compared to the general population in terms of subtype, age, gender and IBD medications...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27933644/quantitative-determination-and-evaluation-of-paris-polyphylla-var-yunnanensis-with-different-harvesting-time-using-uplc-uv-ms-and-ft-ir-spectroscopy-in-combination-with-partial-least-squares-discriminant-analysis
#3
Yuan-Gui Yang, Ji Zhang, Yan-Li Zhao, Jin-Yu Zhang, Yuan-Zhong Wang
A rapid method was developed and validated by ultra performance liquid chromatography-triple quadrupole mass spectroscopy with ultraviolet detection (UPLC-UV-MS) for simultaneous determination of paris saponin I, paris saponin II, paris saponin VI and paris saponin VII. Partial least squares discriminant analysis (PLS-DA) based on UPLC and Fourier transform infrared (FT-IR) spectroscopy was employed to evaluate Paris polyphylla var. yunnanensis (PPY) of different harvesting time. Quantitative determination implied that the various content of bioactive compounds with different harvesting time may lead to different pharmacological effects, the average content of total saponins for PPY from eight years was higher than that from others...
December 9, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27933615/immediate-release-versus-controlled-release-carbamazepine-in-the-treatment-of-epilepsy
#4
REVIEW
Graham Powell, Matthew Saunders, Alexandra Rigby, Anthony G Marson
BACKGROUND: Carbamazepine (CBZ) is a commonly used drug for epilepsy that is associated with troublesome adverse events including dizziness, double vision, drowsiness, poor co-ordination and unsteadiness. These adverse events often occur during peaks in drug plasma concentration. These adverse events may limit the daily dose of CBZ that can be tolerated and reduce the chances of seizure control in patients who require high doses. A controlled-release formulation of CBZ delivers the same dose over a longer period of time when compared to a standard immediate-release formulation, thereby reducing post-dose peaks in CBZ plasma concentration and potentially reducing adverse events...
December 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27933594/vegetable-peel-waste-for-the-production-of-zno-nanoparticles-and-its-toxicological-efficiency-antifungal-hemolytic-and-antibacterial-activities
#5
T V Surendra, Selvaraj Mohana Roopan, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Gargi Sarkar, K Suthindhiran
Zinc oxide (ZnO) nanoparticles (NPs) are important materials when making different products like sun screens, textiles, and paints. In the current study, the photocatalytic effect of prepared ZnO NPs from Moringa oleifera (M. oleifera) was evaluated on degradation of crystal violet (CV) dye, which is largely released from textile industries and is harmful to the environment. Preliminarily, ZnO NP formation was confirmed using a double beam ultraviolet visible (UV-Vis) spectrophotometer; further, the NP size was estimated using XRD analysis and the functional group analysis was determined using Fourier transform infrared (FT-IR) spectroscopy...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27933496/green-synthesis-of-pd-walnut-shell-nanocomposite-using-equisetum-arvense-l-leaf-extract-and-its-application-for-the-reduction-of-4-nitrophenol-and-organic-dyes-in-a-very-short-time
#6
Maryam Bordbar, Nafiseh Mortazavimanesh
Palladium nanoparticles (PdNPs) have been immobilized on the surface of walnut shell powder using Equisetum arvense L. leaf extract as reducing and stabilizing agents in this work. FT-IR spectroscopy, UV-Vis spectroscopy, photoluminescence spectroscopy, X-ray diffraction (XRD) pattern, field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS), and transmission electron microscopy (TEM) have been used in the characterization of the nanocomposites thus prepared. High catalytic activity was shown by these nanocomposites in the reduction of different dyes...
December 8, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27933483/covalent-immobilization-of-human-placental-17%C3%AE-hydroxysteroid-dehydrogenase-type-1-onto-glutaraldehyde-activated-silica-coupled-with-lc-tof-ms-for-anti-cancer-drug-screening-applications
#7
Yin Bai, Wen-Di Zhou, Xian-Min Mu, Qian Zhang, Chen Yu, Bin Di, Meng-Xiang Su
Human 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), a potential target in breast cancer prevention and therapy, was extracted from human placenta and immobilized on nonporous silica (∼5 μm) with a covalent method for the first time. The optimum initial enzyme concentration and immobilization time during the immobilization process were 0.42 mg mL(-1) and 12 h, repectively. The binding was confirmed by scanning electron microscope (SEM) and infrared spectroscopy (FT-IR). It could improve the pH, thermal and storage stability compared to free enzyme...
December 8, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27933433/full-length-infectious-clone-of-an-iranian-isolate-of-chicken-anemia-virus
#8
Amir Kaffashi, Fatemeh Eshratabadi, Abdelhamed Shoushtari
An Iranian field strain of chicken anemia virus (CAV), designated IR CAV, was isolated in the Marek's disease virus-transformed lymphoblastoid cell line MDCC-MSB1 (MSB1) culture for the first time. The full-length CAV DNA of this strain was cloned in the bacterial plasmid pTZ57R/T to create the molecular clone pTZ-CAV. The nucleotide and deduced amino acid sequences of viral proteins of IR CAV were compared with those of representative CAV sequences including reference and commercial vaccine strains. IR CAV was not related to vaccine strains and also found to have glutamine at positions 139 and 144 confirming previous studies in which such mutations were associated with a slow rate of virus spread in cell culture...
December 8, 2016: Virus Genes
https://www.readbyqxmd.com/read/27933387/effect-of-vitamin-d-on-biochemical-parameters-in-polycystic-ovary-syndrome-women-a-meta-analysis
#9
Yunping Xue, Pengfei Xu, Kai Xue, Xiaoyi Duan, Jian Cao, Ting Luan, Qian Li, Lin Gu
AIM: To investigate the therapeutical effect of vitamin D supplementation on the metabolism and endocrine parameters of PCOS patients. MATERIALS AND METHODS: Clinical studies investigating the therapeutic effect of vitamin D supplementation on PCOS patients were selected by searching PubMed, Embase, The Cochrane library and Web of Science until April 2016. The included articles were selected according to the inclusion criteria. Serum HOMA-IR, QUICKI, LDL, DHEAS, free testosterone (FT), total testosterone (TT), PTH, 25-hydroxy-vitamin D, and triglyceride of PCOS patients were enrolled for evaluating the therapeutic effects of vitamin D...
December 9, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27932386/aberrant-expression-of-fbxo2-disrupts-glucose-homeostasis-through-ubiquitin-mediated-degradation-of-insulin-receptor-in-obese-mice
#10
Bin Liu, Han Lu, Duanzhuo Li, Xuelian Xiong, Lu Gao, Zhixiang Wu, Yan Lu
Insulin resistance is a critical factor in the development of metabolic disorders, including type 2 diabetes (T2DM). However, its molecular mechanisms remain incompletely understood. In the present study, we found that F-box only protein 2 (FBXO2), a substrate recognition component of SKP1-Cullin1-F-box protein (SCF) E3 ubiquitin ligase complex, were up-regulated in livers of obese mice. Furthermore, using a protein purification approach combined with high performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS), we carried out a system-wide screening of FBXO2 substrates, in which insulin receptor (IR) was identified as a substrate for FBXO2...
December 8, 2016: Diabetes
https://www.readbyqxmd.com/read/27932203/neural-connection-supporting-endogenous-5-hydroxytryptamine-influence-on-autonomic-activity-in-medial-prefrontal-cortex
#11
Hao-Qiang Zhang, Yong Zhang, Lin Liu, Jin-Lian Li, Ya-Cheng Lu, Ying-Ying Yu, Hui Li, Ting Zhang, Ying-Shing Chan, Fu-Xing Zhang, Yun-Qing Li
5-hydroxytryptamine (5-HT) transmission in the medial prefrontal cortex (mPFC) enhances or suppresses signal outflow to influence emotion-/cognition-based function performances and, putatively, the autonomic responses. The top-down cortical modulation of autonomic activities may be mediated in part through projections from mPFC to brain stem dorsal vagal complex (DVC). The abundant and heterogeneous densities of 5-HT fibers across laminae in mPFC suggest serotonergic innervation of mPFC-DVC projection neurons whereby endogenous 5-HT acts to regulate autonomic activities...
December 1, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27931995/descriptive-epidemiology-of-deployment-related-medical-conditions-and-shipboard-training-related-injuries-in-a-chinese-navy-population
#12
R-R Qi, J-Q Wang, L-L Pan, W Zhou, J-L Liu, J-T Ju, Y-L Cai
OBJECTIVES: To investigate the deployment-related medical conditions and shipboard tactical training-related injuries in a Chinese Navy population. STUDY DESIGN: A retrospective study with the Chinese Navy was conducted. METHODS: The medical records of 1543 Navy crewmembers from 2011 to 2015 were collected. The distribution and incidence rate (IR) of different types of medical conditions were provided and compared between the Aden Gulf deployment and nondeployment periods...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931981/relative-contribution-of-muscle-and-liver-insulin-resistance-to-dysglycemia-in-postmenopausal-overweight-and-obese-women-a-monet-group-study
#13
Belinda Elisha, Emmanuel Disse, Katherine Chabot, Nadine Taleb, Denis Prud'homme, Sophie Bernard, Rémi Rabasa-Lhoret, Jean-Philippe Bastard
OBJECTIVES: The relative contribution of muscle and liver insulin resistance (IR) in the development of dysglycemia and metabolic abnormalities is difficult to establish. The present study aimed to investigate the relative contribution of muscle IR vs. liver IR to dysglycemia in non-diabetic overweight or obese postmenopausal women and to determine differences in body composition and cardiometabolic indicators associated with hepatic or muscle IR. MATERIAL AND METHODS: Secondary analysis of 156 non-diabetic overweight or obese postmenopausal women...
December 5, 2016: Annales D'endocrinologie
https://www.readbyqxmd.com/read/27931589/a-new-chemical-compound-necrox-7-acts-as-a-necrosis-modulator-by-inhibiting-high-mobility-group-box-1-protein-release-during-massive-ischemia-reperfusion-injury
#14
J H Lee, K M Park, Y J Lee, J H Kim, S H Kim
BACKGROUND: Necrotic cell death is common in a wide variety of pathologic conditions, including ischemia-reperfusion (IR) injury. The aim of this study was to develop an IR injury-induced hepatic necrosis model in dogs by means of selective left hepatic inflow occlusion and to test the efficacy of a new chemical compound, NecroX-7, against the IR injury-induced hepatic damage. METHODS: A group of male Beagle dogs received intravenous infusions of either vehicle or different doses of NecroX-7 (1...
December 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27931163/preparation-characterization-and-in-vitro-anticoagulant-activity-of-corn-stover-xylan-sulfates
#15
He-Li Cheng, Hao Liu, Qing-Hua Feng, Yi-Min Xie, Huai-Yu Zhan
A new anticoagulant agent was prepared by introducing sulfate groups into corn stover xylan through homogeneous reactions. Three organic solvents, N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO) and formamide (FA), were adopted as reaction media, with the assistance of LiCl. Structural characterization by FT-IR and (13)CNMR showed that xylan sulfate (XS) could be successfully synthesized with SO3∙Pyridine (SO3∙Py) complexes sulfation reagent in the three media. The effect of sulfation temperature, sulfation time, media type and molar ratio of -SO3/-OH on the degree of substitution (DS) and degree of the polymerization (DP) were studied...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27931150/in-vitro-synergism-of-a-water-insoluble-fraction-of-uncaria-tomentosa-combined-with-fluconazole-and-terbinafine-against-resistant-non-candida-albicans-isolates
#16
Renata Cougo Moraes, Anderson Ramos Carvalho, Aline Jacobi Dalla Lana, Samuel Kaiser, Bruna Pippi, Alexandre Meneghello Fuentefria, George González Ortega
CONTEXT: Uncaria tomentosa D.C. (Rubiaceae) has several biological activities, including activity against resistant Candida strains. The synergistic interaction with terbinafine or fluconazole can be an important alternative to overcome this resistance. OBJECTIVES: The potential synergy between a water insoluble fraction (WIF) from Uncaria tomentosa bark and the antifungals terbinafine (TRB) and fluconazole (FLZ) against non-Candida albicans resistant strains was investigated...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27931003/multivalent-calix-4-arene-based-fluorescent-sensor-for-detecting-silver-ions-in-aqueous-media-and-physiological-environment
#17
Behzad Lotfi, Aliakbar Tarlani, Peyman Akbari-Moghaddam, Maryam Mirza-Aghayan, Ali Ahmadi Peyghan, Jacques Muzart, Reza Zadmard
A new derivative of dipodal 1,3-calix[4]arene-based chemosensor (R), which was containing several binding sites have been synthesized and characterized by NMR, IR and LC-MS spectroscopic methods. The selectivity of Rhas been investigated in aqueous methanol, resulting in fluorescence shift and selective recognition of Ag(+) among 20 various alkali, alkaline earth and transition metal ions. Microstructural features of R and its complex with Ag(+)have been investigated by Atomic Force Microscopy (AFM). AFM images can clearly differentiate R from its complex of Ag(+)...
December 1, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27930544/adiponectin-fbg%C3%A2-%C3%A3-%C3%A2-fins-as-a-predictor-of-insulin-sensitivity-and-metabolic-syndrome-in-patients-with-polycystic-ovary-syndrome
#18
Xiaohui Xu, Yerui Lai, Gangyi Yang, Mengliu Yang, Ling Li, Qin Zhang, Hua Liu, Hongting Zheng, Danping Zhu
The euglycemic-hyperinsulinemic clamp is not available in most clinical settings. An accessible and inexpensive measurement for identifying insulin resistance (IR) is necessary. Our aim is to assess whether the adiponectin (ADI) index (ADI/[FBG × FIns]) is a better surrogate index for the assessment of IR or metabolic syndrome (MetS).A population-based cross-sectional study was conducted including 100 healthy women and 99 polycystic ovary syndrome patients. The euglycemic-hyperinsulinemic clamp was performed...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27929801/preparation-of-native-cellulose-agcl-fiber-with-antimicrobial-activity-through-one-step-electrospinning
#19
Shaojun Wang, Xiaomin Zhang, Ting Luo, Jin Zhu, Shengpei Su
The native Cellulose-AgCl fiber have been firstly fabricated by one-step electrospinning of cellulose solution with poly(vinyl pyrrolidone) (PVP) and AgNO3. X-ray diffraction (XRD), Scanning electron microscopy (SEM), Energy dispersive spectrometer (EDS), Thermo-gravimetric analysis (TGA) and Fourier transform infrared (FT-IR) are used to characterize the crystal structure, morphology and composition of cellulose-AgCl nanocomposites. The results of SEM indicate that the size of AgCl in cellulose fiber matrix is able to be adjusted by the addition of Polyvinylpyrrolidone(PVP)...
December 8, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27929713/postoperative-thyroglobulin-and-neck-ultrasound-in-the-risk-re-stratification-and-decision-to-perform-131-i-ablation
#20
Antonio Matrone, Carla Gambale, Paolo Piaggi, David Viola, Carlotta Giani, Laura Agate, Valeria Bottici, Francesca Bianchi, Gabriele Materazzi, Paolo Vitti, Eleonora Molinaro, Rossella Elisei
CONTEXT: For many years, total thyroidectomy (TTx) and radioiodine remnant ablation (RRA) represented the initial treatment of differentiated thyroid cancer (DTC). There is currently much debate surrounding the clinical impact of RRA, particularly in low (LR) and intermediate (IR) risk DTC. OBJECTIVE: To evaluate the role of postoperative High-Sensitive Thyroglobulin on L-thyroxine (LT4-HSTg) and postoperative neck ultrasound (nUS) in risk re-stratification and decision to perform RRA...
December 8, 2016: Journal of Clinical Endocrinology and Metabolism
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