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https://www.readbyqxmd.com/read/28804629/clinical-presentation-and-treatment-of-gastric-metastasis-from-other-malignancies-of-solid-organs
#1
Tsutomu Namikawa, Eri Munekage, Maho Ogawa, Toyokazu Oki, Masaya Munekage, Hiromichi Maeda, Hiroyuki Kitagawa, Takeki Sugimoto, Michiya Kobayashi, Kazuhiro Hanazaki
The aim of the present study was to analyze the clinicopathologic features and treatment outcomes of gastric metastasis from other malignancies of solid organs. A review was conducted of patients with metastatic tumors in the stomach from other malignancies of solid organs detected endoscopically at the Department of Surgery, Kochi Medical School, from January 1991 to December 2015. Seven patients (four men and three women), with a median age of 64 years (range, 42-71 years), had metastatic gastric tumors. Median tumor size was 7...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28804625/the-relationship-between-tumor-necrosis-factor-%C3%AE-polymorphisms-and-gastric-cancer-risk-an-updated-meta-analysis
#2
Wenxian Zheng, Shuisheng Zhang, Shenfeng Zhang, Li Min, Yihong Wang, Jian Xie, Yong Hou, Xiufang Tian, Jian Cheng, Kun Liu, Deguo Xu, Xinshuang Yu, Zhen Liu, Yajuan Lv, Ning Liang, Jiandong Zhang, Fengjun Liu, Yuan Tian
The aim of the present study was to evaluate the relationship between tumor necrosis factor-α (TNF-α) and the development of gastric cancer, and to investigate whether it can be used as a biological marker for gastric cancer. In the current study, a new meta-analysis was performed to assess the association between TNF-α gene polymorphisms and gastric cancer susceptibility. Subgroup analyses based on ethnicity, control population source and non-cardia cancers were also conducted. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model...
August 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28801429/multicentric-randomised-study-of-helicobacter-pylori-eradication-and-pepsinogen-testing-for-prevention-of-gastric-cancer-mortality-the-gistar-study
#3
Marcis Leja, Jin Young Park, Raul Murillo, Inta Liepniece-Karele, Sergejs Isajevs, Ilze Kikuste, Dace Rudzite, Petra Krike, Sergei Parshutin, Inese Polaka, Arnis Kirsners, Daiga Santare, Valdis Folkmanis, Ilva Daugule, Martyn Plummer, Rolando Herrero
INTRODUCTION: Population-based eradication of Helicobacter pylori has been suggested to be cost-effective and is recommended by international guidelines. However, the potential adverse effects of widespread antibiotic use that this would entail have not been sufficiently studied. An alternative way to decrease gastric cancer mortality is by non-invasive search for precancerous lesions, in particular gastric atrophy; pepsinogen tests are the best currently available alternative. The primary objective of GISTAR is to determine whether H pylori eradication combined with pepsinogen testing reduces mortality from gastric cancer among 40-64-year-old individuals...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801179/family-history-of-gastric-cancer-is-associated-with-the-risk-of-colorectal-neoplasia-in-korean-population
#4
Yoon Suk Jung, Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
BACKGROUND: Family history of cancers at different sites except for colorectum has not been evaluated as a risk factor for colorectal neoplasia (CRN). AIMS: To investigate CRN risk according to family history of cancers at 12 different sites, including stomach and colorectum. METHODS: A cross-sectional study was performed on 139,497 asymptomatic Koreans who underwent colonoscopy as part of a health check-up. RESULTS: The mean age of the study population was 41...
July 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28799258/helicobacter-pylori-infection-and-serum-level-of-pepsinogen-are-associated-with-the-risk-of-metachronous-gastric-neoplasm-after-endoscopic-resection
#5
Y Kwon, S Jeon, S Nam, I Shin
BACKGROUND: Patients who have undergone endoscopic resection of early gastric cancers (EGCs) are at risk for metachronous gastric neoplasm. AIM: To determine whether serum level of pepsinogen (PG), a marker of gastric atrophy, can determine which patients who have undergone endoscopic submucosal dissection for EGC are at risk for metachronous gastric neoplasm. We also investigated the effects of Helicobacter pylori eradication on metachronous gastric neoplasm incidence...
August 11, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28799174/abdominal-surgery-for-gastric-cancer-following-coronary-artery-bypass-grafting-using-an-in-situ-right-gastroepiploic-artery-graft
#6
Keita Yano, Hideki Tsubota, Yoshio Arai, Toshihiro Abe, Michiya Hanyu
BACKGROUND: The right gastroepiploic artery (RGEA) is often used for coronary artery bypass grafting (CABG) in Japan. As gastric cancer has a high prevalence in many Asian countries, we investigated problems with surgery for gastric cancer after CABG using the RGEA. METHODS: A total of 860 patients underwent CABG using the RGEA between January 1997 and December 2006. Of these, 13 patients underwent surgery for gastric cancer after CABG. In all cases, the RGEA was harvested by the skeletonization technique, and an antegastric route was used for the anastomosis...
August 11, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/28797755/failure-to-rescue-in-patients-undergoing-surgery-for-esophageal-or-gastric-cancer
#7
L A Busweiler, D Henneman, J L Dikken, M Fiocco, M I van Berge Henegouwen, B P Wijnhoven, R van Hillegersberg, C Rosman, M W Wouters, J W van Sandick
BACKGROUND: Complex surgical procedures such as esophagectomy and gastrectomy for cancer are associated with substantial morbidity and mortality. The purpose of this study was to evaluate trends in postoperative morbidity, mortality, and associated failure-to-rescue (FTR), in patients who underwent a potentially curative resection for esophageal or gastric cancer in the Netherlands, and to investigate differences between the two groups. METHODS: All patients with esophageal or gastric cancer who underwent a potentially curative resection, registered in the Dutch Upper GI Cancer Audit (DUCA) between 2011 and 2014, were included...
July 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28797248/the-role-of-bariatric-surgery-to-treat-diabetes-current-challenges-and-perspectives
#8
REVIEW
Chrysi Koliaki, Stavros Liatis, Carel W le Roux, Alexander Kokkinos
Bariatric surgery is emerging as a powerful weapon against severe obesity and type 2 diabetes mellitus (T2DM). Given its role in metabolic regulation, the gastrointestinal tract constitutes a meaningful target to treat T2DM, especially in light of accumulating evidence that surgery with gastrointestinal manipulations may result in T2DM remission (metabolic surgery). The major mechanisms mediating the weight loss-independent effects of bariatric surgery comprise effects on tissue-specific insulin sensitivity, β-cell function and incretin responses, changes in bile acid composition and flow, modifications of gut microbiota, intestinal glucose metabolism and increased brown adipose tissue metabolic activity...
August 10, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28797101/two-populations-of-less-virulent-helicobacter-pylori-genotypes-in-bangladesh
#9
Hafeza Aftab, Muhammad Miftahussurur, Phawinee Subsomwong, Faruque Ahmed, A K Azad Khan, Takashi Matsumoto, Rumiko Suzuki, Yoshio Yamaoka
Bangladesh has a population with a low gastric cancer risk but high prevalence of Helicobacter pylori infection. Several studies have examined virulence genes in H. pylori from Bangladesh. We analyzed cagA and vacA subtypes and their association with severe histology phenotypes, and analyzed population types among Bangladeshi strains. We included patients who underwent endoscopy in Dhaka. Sequences of virulence genes and seven housekeeping genes were obtained by next generation sequencing and confirmed by Sanger sequencing...
2017: PloS One
https://www.readbyqxmd.com/read/28796378/functional-genetic-variants-of-xrcc4-and-ercc1-predict-survival-of-gastric-cancer-patients-treated-with-chemotherapy-by-regulating-the-gene-expression
#10
Lei Cheng, Lixin Qiu, Mengyun Wang, Ruoxin Zhang, Menghong Sun, Xiaodong Zhu, Yanong Wang, Qingyi Wei
DNA repair protects genomic integrity and may modulate chemotherapy efficacy. Few large-scale studies have evaluated predictive roles of genetic variants of DNA repair genes in survival of Chinese gastric cancer (GCa) patients treated with chemotherapy. Here, we assessed the roles of 35 single nucleotide polymorphisms (SNPs) in DNA repair genes in survival of 1,002 GCa patients, of whom 694 received chemotherapy and 308 did not. Among patients receiving chemotherapy, the ERCC1 rs2298881A allele was associated with a better survival [hazards ratio (HR) =0...
August 10, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28796034/the-association-between-xpg-polymorphisms-and-cancer-susceptibility-evidence-from-observational-studies
#11
Cuihong Han, Xiaoyi Huang, Ruixi Hua, Shujie Song, Lihua Lyu, Na Ta, Jinhong Zhu, Peixi Zhang
BACKGROUND: Exposure to environmental carcinogens can cause damages to DNA. If not properly repaired, the DNA damages may increase the risk of carcinogenesis. Xeroderma pigmentosum group G (XPG) gene is an essential gene in the nucleotide excision repair (NER) pathway. The association between XPG polymorphisms and cancer susceptibility has been the focus of attention in the molecular epidemiology of cancer. However, the conclusions have been divergent. Therefore, we conducted a comprehensive meta-analysis to precisely evaluate the association of 3 frequently investigated XPG polymorphisms (rs751402, rs873601, and rs2296147) with cancer risk...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28794960/gastric-perforation-after-duodenopancreatectomy
#12
Henrik Bäcker, Frank Jp Beeres, Marco Rossi, Andreas Scheiwiller
Fungal and bacterial infections are often which may cause sepsis. Mucormycosis is an unfrequent, but often life-threatening disease. A timely diagnosis and treatment is the cornerstone of success. An increase in incidence can be expected, given an aging population and increasing incidence of obesity, diabetes and cancer. We present a rare case where early diagnosis has helped to treat the patient mainly with antifungal therapy as surgical therapy has had high risk of complications.
December 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28793921/standardising-the-reporting-of-outcomes-in-gastric-cancer-surgery-trials-protocol-for-the-development-of-a-core-outcome-set-and-accompanying-outcome-measurement-instrument-set-the-gastros-study
#13
Bilal Alkhaffaf, Anne-Marie Glenny, Jane M Blazeby, Paula Williamson, Iain A Bruce
BACKGROUND: Gastric cancer is one of the leading causes of cancer-related deaths worldwide. Whilst surgery is the mainstay of curative treatment, it is associated with significant risks. Surgical strategies for treating gastric cancer should be based on evidence from systematic reviews of well-designed randomised controlled trials. However, inconsistencies in the reporting of outcomes from these trials makes evidence synthesis unreliable. We present a protocol for an international consensus study to develop a standardised set of outcomes and measurement tools - a 'core outcome set' (COS) - to be used by all future trials examining therapeutic surgical interventions for gastric cancer...
August 9, 2017: Trials
https://www.readbyqxmd.com/read/28793755/cancer-screening-rate-in-diabetic-patients-in-the-korean-population-results-from-korean-national-health-and-nutrition-examination-survey-knhanes-2007-2009
#14
Kumban Walter Chuck, Minji Hwang, Kui Son Choi, Mina Suh, Jae Kwan Jun, Boyoung Park
Purpose: To investigate the screening rate for gastric, breast, and cervical cancer in people with diabetes compared with people without diabetes. Methods: Data from the Korean National Health and Nutrition Examination survey 2007-2009 was used. Cancer-free men who were 40 years old and over and women who were 30 years old and over were included. Lifetime screening rate and regular screening rate were compared in people with and without diabetes. Results: People with diabetes received less cancer screening than people without diabetes in their lifetime (53...
August 10, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28791679/effect-of-age-on-rates-of-palliative-surgery-and-chemotherapy-use-in-patients-with-locally-advanced-or-metastatic-gastric-cancer
#15
S D Nelen, M van Putten, V E P P Lemmens, K Bosscha, J H W de Wilt, R H A Verhoeven
BACKGROUND: This study assessed trends in the treatment and survival of palliatively treated patients with gastric cancer, with a focus on age-related differences. METHODS: For this retrospective, population-based, nationwide cohort study, all patients diagnosed between 1989 and 2013 with non-cardia gastric cancer with metastasized disease or invasion into adjacent structures were selected from the Netherlands Cancer Registry. Trends in treatment and 2-year overall survival were analysed and compared between younger (age less than 70 years) and older (aged 70 years or more) patients...
August 9, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28790411/prognostic-value-of-a-25-gene-assay-in-patients-with-gastric-cancer-after-curative-resection
#16
Xiaohong Wang, Yiqiang Liu, Zhaojian Niu, Runjia Fu, Yongning Jia, Li Zhang, Duanfang Shao, Hong Du, Ying Hu, Xiaofang Xing, Xiaojing Cheng, Lin Li, Ting Guo, Ziyu Li, Qunsheng Ji, Lianhai Zhang, Jiafu Ji
This study aimed to develop and validate a practical, reliable assay for prognosis and chemotherapy benefit prediction compared with conventional staging in Gastric cancer (GC). Twenty-three candidate genes with significant correlation between quantitative hybridization and microarray results plus 2 reference genes were selected to form a 25-gene prognostic classifier, which can classify patients into 3 distinct groups of different risk of mortality obtained by analyzing microarray data from 78 frozen tumor specimens...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782119/systematic-review-with-meta-analysis-diagnostic-performance-of-the-combination-of-pepsinogen-gastrin-17-and-anti-helicobacter-pylori-antibodies-serum-assays-for-the-diagnosis-of-atrophic-gastritis
#17
REVIEW
R M Zagari, S Rabitti, D C Greenwood, L H Eusebi, A Vestito, F Bazzoli
BACKGROUND: The combination of pepsinogen, gastrin-17 and anti-H. pylori antibodies serological assays (panel test) is a non-invasive tool for the diagnosis of atrophic gastritis. However, the diagnostic reliability of this test is still uncertain. AIM: To assess the diagnostic performance of the serum panel test for the diagnosis of atrophic gastritis. METHODS: Medline via PubMed, Embase, Scopus, Cochrane Library databases and abstracts of international conferences proceedings were searched from January 1995 to December 2016 using the primary keywords "pepsinogens," "gastrin," "atrophic gastritis," "gastric precancerous lesions...
August 7, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28780045/sleeve-gastrectomy-with-duodenojejunal-end-to-side-anastomosis-in-the-treatment-of-type-2-diabetes-the-initial-experiences-in-a-chinese-population-with-a-more-than-4-year-follow-up
#18
Xiaojiao Ruan, Weijian Zhang, Huajie Cai, Ru Zheng, Feizhao Jiang, Hengliang Zhu
BACKGROUND: Gastric bypass has been thought to be associated with a risk of gastric cancer, particularly in Asia. Sleeve gastrectomy with duodenojejunal end-to-side anastomosis (SG-DJESA) was suggested to be a better-designed procedure to avoid this risk, and it also has other advantages. OBJECTIVE: We aimed to evaluate the clinical efficacy and feasibility of SG-DJESA in the treatment of nonobese patients with type 2 diabetes (T2D). SETTING: University Hospital, China...
July 14, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28771198/prevention-of-gastric-cancer-eradication-of-helicobacter-pylori-and-beyond
#19
REVIEW
Tetsuya Tsukamoto, Mitsuru Nakagawa, Yuka Kiriyama, Takeshi Toyoda, Xueyuan Cao
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium Helicobacter pylori is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that H. pylori infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of H. pylori significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of H...
August 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28771157/the-risk-of-cancer-as-a-result-of-elevated-levels-of-nitrate-in-drinking-water-and-vegetables-in-central-india
#20
Pinky Taneja, Pawan Labhasetwar, Pranav Nagarnaik, Jeroen H J Ensink
The objective of the present study was to determine the effect of nitrates on the incidence of gastrointestinal (GI) cancer development. Nitrate converted to nitrite under reducing conditions of gut results in the formation of N-nitrosamines which are linked to an increased gastric cancer risk. A population of 234 individuals with 78 cases of GI cancer and 156 controls residing at urban and rural settings in Nagpur and Bhandara districts of India were studied for 2 years using a case-control study. A detailed survey of 16 predictor variables using Formhub software was carried out...
August 2017: Journal of Water and Health
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