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gastric cancer risk

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https://www.readbyqxmd.com/read/29353347/serum-pepsinogen-levels-indicate-the-requirement-of-upper-gastrointestinal-endoscopy-among-group-a-subjects-of-abc-classification-a-multicenter-study
#1
Daisuke Chinda, Tadashi Shimoyama, Tatsuya Mikami, Tetsu Arai, Daisuke Chiba, Yoshio Sasaki, Kazuo Komai, Yoshihiko Sawada, Yoshiharu Saito, Hironobu Chiba, Shinsaku Fukuda
BACKGROUND: ABC classification has been used to assess the risk for gastric cancer. The current problem of ABC classification is that Group A contains individuals with current and past H. pylori infection. The aims of this study were to assesse the proportion of current and past infection in Group A and to establish a criteria for the identification of subjects with past infection from Group A subjects with negative results of urea breath test (UBT) and/or stool antigen test. METHODS: 201 subjects classified into Group A received UBT and/or stool antigen test, and also subsequent upper gastrointestinal endoscopy...
January 20, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29353152/tgf%C3%AE-c-509t-tgf%C3%AE-t869c-xrcc1-arg194trp-ikb%C3%AE-c642t-il4-c-590t-genetic-polymorphisms-combined-with-socio-economic-lifestyle-diet-factors-and-gastric-cancer-risk-a-case-control-study-in-south-indian-population
#2
Dhayalan Pavithra, Majumdar Gautam, Ranganathan Rama, Rajaraman Swaminathan, Gopisetty Gopal, Ayyalur Seshadri Ramakrishnan, Thangarajan Rajkumar
BACKGROUND: Gastric cancer is worldwide the third major cause of cancer related death. Risk factors for gastric cancer includes Helicobacter pylori infection, gastric ulcer, less hygienic condition, use of tobacco, alcohol consumption, use of salted, smoked food, genetic alterations etc. In order to identify the risk factors associated with gastric cancer in South Indian population a case-control study involving 200 proven gastric cancer cases and 400 controls was conducted. METHODS: A structured questionnaire was used to interview all the subjects who participated in our study...
January 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29350665/laparoscopic-gastric-bypass-with-remnant-gastrectomy-in-a-super-super-obese-patient-with-gastric-metaplasia-a-surgical-hazard
#3
Francesco Tartamella, Gabriele Petracca, Andrea Romboli, Federico Marchesi
The endoscopic inaccessibility of the gastric remnant after Roux-en-Y gastric bypass (RYGBP) for morbid obesity represents an important issue for patients with familiar history of gastric cancer (GC) or affected by premalignant lesions, such as intestinal metaplasia. If a different bariatric procedure is contraindicated, RYGBP with remnant gastrectomy represents a reasonable alternative, significantly reducing the risk of GC but potentially increasing postoperative morbidity. For this reason, only few cases have been reported in the recent Literature and none regarding a super-super obese patient...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29345408/the-effect-of-eradication-of-helicobacter-pylori-on-gastric-cancer-prevention-in-healthy-asymptomatic-populations
#4
Suh Eun Bae, Kee Don Choi, Jaewon Choe, Seon Ok Kim, Hee Kyong Na, Ji Young Choi, Ji Yong Ahn, Kee Wook Jung, JeongHoon Lee, Do Hoon Kim, Hye-Sook Chang, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Although many epidemiologic studies have evaluated the effect of Helicobacter pylori eradication on gastric cancer, the effect is still uncertain in general populations. We evaluated whether H. pylori eradication would affect the incidence of gastric cancer in healthy asymptomatic populations. MATERIALS AND METHODS: We performed a retrospective cohort study in 38 984 asymptomatic individuals, who underwent health screening examinations more than twice between 2005 and 2016...
January 18, 2018: Helicobacter
https://www.readbyqxmd.com/read/29344235/metronomic-chemotherapy-remodel-cancer-associated-fibroblasts-to-decrease-chemoresistance-of-gastric-cancer-in-nude-mice
#5
Chao Wang, Wenqi Xi, Jinling Jiang, Jun Ji, Yingyan Yu, Zhenggang Zhu, Jun Zhang
The present study aimed to evaluate whether capecitabine or 5-fluorouracil (5-Fu) chemotherapy with the metronomic pattern may cause significant chemoresistance compared with the traditional pattern, and whether CAFs are involved in drug resistance. SGC-7901 cells were subcutaneously injected into the nude mice, and the mice were divided into five groups: The control group, intraperitoneally injected with normal saline; the 5-Fu conventional dose group [5-Fu maximum tolerated dose (MTD) group], intraperitoneally injected with 50 mg/kg, twice per week for 2 weeks, with an 1-week discontinuation for 6 weeks; the capecitabine conventional dose group (capecitabine MTD group), intragastric 500 mg/kg, twice per week for 2 weeks, with a 1-week discontinuation for 6 weeks; the 5-Fu metronomic group [5-Fu low-dose metronomic (LDM) group], intraperitoneally injected with 15 mg/kg, twice a week for 6 weeks; and the capecitabine metronomic group (capecitabine LDM group), intragastric administration at 200 mg/kg, twice a week for 6 weeks...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344226/analysis-of-survival-and-prognosis-of-298-gastric-adenocarcinoma-patients-with-no-distant-metastasis
#6
Luguang Liu, Hongbo Hao, Lijuan Zhao, Junxia Hu, Baocai Si
This study investigated the survival and prognosis of 298 gastric adenocarcinoma patients with no distant metastasis. For analysis and comparison of the prognosis of patients, a retrospective analysis was performed in 298 patients with perfect clinical data and follow-up data who received the D2 resections for gastric cancer in Shandong Provincial Hospital Affiliated to Shandong University between January, 2005 and January, 2012, and were diagnosed as gastric adenocarcinoma with no distant metastasis in postoperative pathological examination...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344191/expression-and-prognostic-significance-of-cyclin-dependent-kinase-inhibitor-1a-in-patients-with-resected-gastric-adenocarcinoma
#7
Youdong Lin, Xiaoting Wang, Yinghao Yu, Wei Liu, Feilai Xie, Xuenong Ouyang, Qiaojia Huang
Cyclin-dependent kinase inhibitor 1A (CDKN1A) is an important cell cycleregulator, and has been identified to exhibit aberrant expression in various types of cancer tissues. However, the association between CDKN1A expression level and prognosis in patients with resected gastric adenocarcinoma (RGA) requires additional elucidation. In the present study, the CDKN1A expression profile in RGA tissues obtained from 217 patients were analyzed using immunohistochemistry. Its prognostic significance was evaluated by using the χ2 test, Kaplan-Meier curves and the log-rank test, and a multivariate Cox model analysis, during a median follow-up time of 51 months...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29344113/downregulated-mirna-1269a-variant-rs73239138-decreases-the-susceptibility-to-gastric-cancer-via-targeting-znf70
#8
Wenshuai Li, Huilu Zhang, Pei Min, Jie Zhu, Diannan Xu, Weiru Jiang, Yanyun Ma, Jigang Qiu, Weihong Xu, Jian Chen, Mingqing Zhang, Min Li, Dongqin Yang, Jianping Shi, Jun Zhang, Jie Liu
Although emerging evidence has indicated that single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) are associated with susceptibility to gastric cancer, a limited number of studies have revealed the underlying molecular mechanisms. In the present study, the results suggested that miR-1269a rs73239138 has a role in decreasing the risk of gastric cancer. The level of miR-1269a variant expression was significantly downregulated compared with the wild-type miR-1269a in the gastric cells (Fig. 1). Furthermore, overexpression of miR-1269a inhibited apoptosis of gastric cancer cells...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29343955/lysyl-oxidase-activates-cancer-stromal-cells-and-promotes-gastric-cancer-progression-quantum-dot-based-identification-of-biomarkers-in-cancer-stromal-cells
#9
Chunwei Peng, Jiuyang Liu, Guifang Yang, Yan Li
Purpose: Semiconductor quantum dots (QDs) are a promising alternative to organic fluorescent dyes for multiplexed molecular imaging of cancer stroma, which have great advantages in holistically analyzing the complex interactions among cancer stromal components in situ. Patients and methods: A QD probe-based multiplexed spectral molecular imaging method was established for simultaneous imaging. Three tissue microarrays (TMAs) including 184 gastric cancer (GC) tissues were constructed for the study...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29341149/quality-of-life-implications-of-risk-reducing-cancer-surgery
#10
REVIEW
A M Altman, J Y C Hui, T M Tuttle
BACKGROUND: Modern advances in genetic sequencing techniques have allowed for increased availability of genetic testing for hereditary cancer syndromes. Consequently, more people are being identified as mutation carriers and becoming aware of their increased risk of malignancy. Testing is commonplace for many inheritable cancer syndromes, and with that comes the knowledge of being a gene carrier for some patients. With increased risk of malignancy, many guidelines recommend that gene carriers partake in risk reduction strategies, including risk-reducing surgery for some syndromes...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29341148/outcomes-after-prophylactic-gastrectomy-for-hereditary-diffuse-gastric-cancer
#11
R T van der Kaaij, J P van Kessel, J M van Dieren, P Snaebjornsson, O Balagué, F van Coevorden, L E van der Kolk, K Sikorska, A Cats, J W van Sandick
BACKGROUND: Patients with hereditary diffuse gastric cancer and a CDH1 mutation have a 60-80 per cent lifetime risk of developing diffuse gastric cancer. Total prophylactic gastrectomy eliminates this risk, but is associated with considerable morbidity. The effectiveness (removal of all gastric mucosa) and outcomes of this procedure were evaluated retrospectively. METHODS: All consecutive individuals undergoing a prophylactic gastrectomy for a CDH1 mutation or gastric signet ring cell foci at the authors' institute between 2005 and 2017 were included...
January 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29338698/enteral-immunonutrition-versus-enteral-nutrition-for-gastric-cancer-patients-undergoing-a-total-gastrectomy-a-systematic-review-and-meta-analysis
#12
Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan
BACKGROUND: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes...
January 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29334503/family-history-of-autoimmune-diseases-and-risk-of-gastric-cancer-a-national-cohort-study
#13
Jianguang Ji, Jan Sundquist, Kristina Sundquist
A personal history of autoimmune diseases is associated with an increased incidence of gastric cancer, but whether they share familial susceptibility is still unknown. The contribution of shared environmental or genetic factors toward the observed familial aggregation has not been determined. We used a few Swedish registers, including the Swedish Multigeneration Register and the Cancer Register, to examine the familial risk of gastric cancer among individuals with a family history of a set of autoimmune diseases...
January 12, 2018: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/29332452/the-dnmt3b-579g-t-polymorphism-is-significantly-associated-with-the-risk-of-gastric-cancer-but-not-lung-cancer-in-chinese-population
#14
Bifeng Chen, Jingdong Wang, Xiuli Gu, Jingli Zhang, Jiankun Zhang, Xianhong Feng
The -149C>T and -579G>T, 2 single nucleotide polymorphisms in de novo methyltransferase 3B gene promoter, have been previously reported to potentially alter the promoter activity and to influence cancer risk. However, the results from previous studies remain conflicting rather than conclusive. In view of this, we conducted a case-control study and then a meta-analysis to examine the association between these 2 single-nucleotide polymorphisms with risk of lung and gastric cancer in Chinese population. The genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and confirmed by sequencing...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29332342/study-on-the-association-between-pi3k-akt-mtor-signaling-pathway-gene-polymorphism-and-susceptibility-to-gastric-cancer
#15
Lei Qi, Kewen Sun, Yun Zhuang, Jing Yang, Jianping Chen
PURPOSE: Excessive activation of PI3K/AKT/mTOR signaling pathway is one of the most common changes in human cancers, and single nucleotide polymorphisms (SNPs) existing in its functional region can affect the occurrence process of a variety of cancers. This study aimed to screen out the SNPs associated with susceptibility to gastric cancer in the PI3K/AKT/mT0R signaling pathway. METHODS: In this case-control study, the tagging SNPs in the promoter region5'-UTR, exon region or 3'-UTR of PIK3CA, PIK3CB, PIK3R1, PIK3R2, PIK3R3, AKT1, AKT2, AKT3 and mTOR genes were screened out...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331945/risk-factors-for-gastric-cancer-is-it-time-to-discard-ppis
#16
Lucrezia Laterza, Franco Scaldaferri, Antonio Gasbarrini
No abstract text is available yet for this article.
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331883/curative-distal-pancreatectomy-in-patients-with-acinar-cell-carcinoma-of-pancreas-diagnosed-by-endoscopic-aspiration-via-esophago-jejunostomy-a-successful-case-report
#17
Takeomi Hamada, Atsushi Nanashima, Masahide Hiyoshi, Makoto Ikenoue, Naoya Imamura, Koichi Yano, Yoshiro Fujii, Yoshimasa Kubota, Tesshin Ban, Hiroshi Kawakami, Yuichiro Sato
INTRODUCTION: This is a case report on the advances in preoperative endoscopic-guided fine-needle-aspiration (FNA) diagnosis for pancreatic carcinoma to achieve a curative operation even in patients who have a history of total gastrectomy. CASE PRESENTATION: A 65-year-old man, who underwent total gastrectomy for gastric cancer 13 years ago, had discomfort in the left lateral abdomen. A 3-cm hypovascular mass accompanying a large distal pseudocyst in the pancreatic tail was observed on computed tomography...
January 8, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29330724/a-novel-nomogram-for-predicting-postsurgical-intra-abdominal-infection-in-gastric-cancer-patients-a-prospective-study
#18
Chen-Chen Mao, Xiao-Dong Chen, Ji Lin, Wei-Shan Zhu-Ge, Zhong-Dong Xie, Xi-Yi Chen, Feng-Min Zhang, Rui-Sen Wu, Wei-Teng Zhang, Neng Lou, Li Shi, Guan-Bao Zhu, Xian Shen
BACKGROUND: This study aimed to determine the relationship between intra-abdominal infection (IAI) and sarcopenia prospectively and to construct a nomogram to identify patients at a high risk of IAI. METHODS: We conducted a prospective study of 682 consecutive patients with gastric cancer who underwent radical gastrectomy. The sarcopenia elements, including lumbar skeletal muscle index, handgrip strength, and gait speed, were measured before surgery. Factors contributing to IAI were determined through univariate and multivariate analysis...
January 12, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29329668/helicobacter-pylori-induces-direct-activation-of-the-lymphotoxin-beta-receptor-and-non-canonical-nuclear-factor-kappa-b-signaling
#19
Michael Hartmut Feige, Michael Vieth, Olga Sokolova, Christian Täger, Michael Naumann
The pathogen Helicobacter pylori, which infects half of the world's population, is a major risk factor for the development of gastric diseases including chronic gastritis and gastric cancer. Among H. pylori's virulence factors is the cytotoxin-associated gene pathogenicity island (cagPAI), which encodes for a type IV secretion system (T4SS). The T4SS induces fast canonical nuclear factor-kappa B (NF-κB) signaling, a major factor increasing inflammation, supressing apoptotic cell death and thereby promoting the development of neoplasia...
January 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29329598/treatment-outcome-of-anti-angiogenesis-through-vegf-pathway-in-the-management-of-gastric-cancer-a-systematic-review-of-phase-ii-and-iii-clinical-trials
#20
Brian Mawalla, Xianglin Yuan, Xiaoxiao Luo, Phillip L Chalya
OBJECTIVES: Advanced gastric cancer poses a therapeutic challenge worldwide. In randomised clinical trials, anti-VEGF has been reported as an essential agent for the treatment of advanced gastric cancer. This review aims at assessing the treatment outcome of anti-angiogenesis therapy through the VEGF pathway in the management of patients with advanced gastric cancer. RESULTS: During this review, 38 clinical trials were identified. Of these, 30 clinical trials were excluded, leaving eight trials of phase II and III...
January 12, 2018: BMC Research Notes
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