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https://www.readbyqxmd.com/read/29161426/family-history-of-gastric-mucosal-abnormality-and-the-risk-of-gastric-cancer-a-population-based-observational-study
#1
Huan Song, Isabella Guncha Ekheden, Alexander Ploner, Jan Ericsson, Olof Nyren, Weimin Ye
Background: An increased prevalence of gastric premalignant abnormalities was reported among relatives of gastric cancer (GC) patients, with rather unexplored clinical significance. Methods: In Swedish computerized pathology registers, we identified, as 'index' persons 232 681 patients who were born after 1931 and underwent endoscopic examination with stomach biopsy between 1979 and 2014. Through linkage with the Multi-Generation Register, we compiled a cohort consisting of 903 337 first-degree relatives of these biopsied patients...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29158794/association-between-sumoylation-related-gene-rs77447679-polymorphism-and-risk-of-gastric-cancer-gc-in-a-chinese-population
#2
Ying Luo, Sihong You, Jirong Wang, Shuling Fan, Jie Shi, Ai Peng, Tingting Yu
Purpose: Sumoylation plays a critical role in gene regulation and tumorigenesis, and is hypothesized to correlate with the development of various cancers. So far, there has been no reported association between sumoylation-related genes and the risk of gastric cancer (GC). Methods: A total of 17 tagging single-nucleotide polymorphisms (tag-SNPs) in 5 sumoylation-related genes were selected and genotyped by SNaPshot in a case-control study, including 1021 GC patients and 1304 controls. Odds ratio (OR) and 95% confidential interval (CI) were computed to evaluate the genetic association of the onset of GC...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29156838/associations-between-dietary-folate-intake-and-risks-of-esophageal-gastric-and-pancreatic-cancers-an-overall-and-dose-response-meta-analysis
#3
Wen Liu, Heng Zhou, Yaoqi Zhu, Chaorong Tie
There are still some controversies on the association between dietary folate intake and the risk of upper gastrointestinal cancers including esophageal, gastric and pancreatic cancers. Hence, a comprehensive meta-analysis on all available literatures was performed to clarify the relationship between dietary folate intake and risks of upper gastrointestinal cancers. An electric search was performed up to December 12(th), 2016 within the PubMed, MEDLINE AND EMBASE databases. Ultimately, a total of 46 studies which evaluated the association between folate intake and risks of upper gastrointestinal cancers were included...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156732/dietary-inflammatory-index-and-the-risk-of-gastric-cancer-in-a-korean-population
#4
Sunghee Lee, Jeonghee Lee, Il Ju Choi, Young-Woo Kim, Keun Won Ryu, Young-Il Kim, Jin-Kyoung Oh, Binh Thang Tran, Jeongseon Kim
We aimed to investigate the association with the Dietary Inflammatory Index (DII™) on the risk of gastric cancer and whether histological type modifies this association. From March 2011 to December 2014, 388 cases and 776 controls were enrolled at the National Cancer Center. Utilizing a food frequency questionnaire, thirty-five food components were used to score the DII. The tertile distribution of DII for controls was as follows: T1: <0.96, T2: 0.96-2.97, and T3: ≥2.97. To investigate the association between DII and the gastric cancer risk, multivariable logistic models were constructed...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155518/a-meta-analysis-of-clinical-trials-over-regimens-with-or-without-cetuximab-for-advanced-gastric-cancer-patients
#5
Lianhua Ji, Dongying Gu, Xinguang Tan, Hui Sun, Jinfei Chen
PURPOSE: To evaluate the efficiency and toxicity of treatment with or without cetuximab in patients with advanced gastric cancer (AGC). METHODS: Randomized phase III clinical trials (RCTs) on chemotherapy with or without cetuximab for AGC were searched in PUBMED and CNKI. A total of 874 patients were analyzed for their overall survival (OS), disease control rate (DCR), and toxicity. Reported hazard ratio (HR) with 95% CI from each study were used as the primary outcome measure...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155082/association-of-gastric-intestinal-metaplasia-and-east-asian-ethnicity-with-the-risk-of-gastric-adenocarcinoma-in-a-u-s-population
#6
Alyssa Y Choi, Lisa L Strate, Matthew C Fix, Rodney A Schmidt, Alexander R Ende, Matthew M Yeh, John M Inadomi, Joo Ha Hwang
BACKGROUND AND AIMS: Although the incidence of gastric cancer is higher than esophageal cancer in the United States, no screening or surveillance guidelines exist. The aim of this study is to evaluate the association between gastric intestinal metaplasia and the risk of gastric cancer in a U.S. tertiary care system with a large immigrant population. METHODS: This is a retrospective case-control study with cases of biopsy-proven gastric cancer matched (by age and gender) to controls without gastric cancer who had undergone EGD...
November 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29154808/genetic-host-factors-in-helicobacter-pylori-induced-carcinogenesis-emerging-new-paradigms
#7
REVIEW
Michiel C Mommersteeg, Jun Yu, Maikel P Peppelenbosch, Gwenny M Fuhler
Helicobacter Pylori is a gram negative rod shaped microaerophilic bacterium that colonizes the stomach of approximately half the world's population. Infection with c may cause chronic gastritis which via a quite well described process known as Correas cascade can progress through sequential development of atrophic gastritis, intestinal metaplasia and dysplasia to gastric cancer. H. pylori is currently the only bacterium that is classified as a class 1 carcinogen by the WHO, although the exact mechanisms by which this bacterium contributes to gastric carcinogenesis are still poorly understood...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29150418/immune-enhancing-formulas-for-patients-with-cancer-undergoing-esophagectomy-systematic-review-protocol
#8
Astrid Naranjo, Elizabeth Isenring, Laisa Teleni
BACKGROUND: Adult patients with an esophageal cancer can potentially be compromised with postoperative leaks or fistulae if patients' nutritional status is in a vulnerable stage. Currently in Australia, there is a growing need for clinicians to know whether use of immune-enhancing formulas (IEFs) containing Arg, omega-3, and RNA are a cost-effective approach compared with isonitrogenous-isocaloric formulas to reduce postoperative infectious complications in esophagectomy patients. Since IEFs may carry higher costs, this has led to inconsistencies in practice among clinicians and hospitals...
November 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29149920/gastrointestinal-and-hepatic-disease-in-the-inflammatory-myopathies
#9
REVIEW
Chiranjeevi Gadiparthi, Amneet Hans, Kyle Potts, Mohammad K Ismail
Although muscle weakness is the pathognomonic feature of idiopathic inflammatory myopathies, systemic organ involvement is not uncommon. The gastrointestinal and hepatic manifestations are well known. Oropharyngeal dysphagia is the most common gastrointestinal symptom and can be severe. Gastric and small intestinal motility disorders, including chronic intestinal pseudo-obstruction, celiac disease, and inflammatory bowel disease have been described. Comprehensive cancer screening is warranted soon after the diagnosis of inflammatory myopathies due to high risk of occult malignancies...
February 2018: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/29148016/association-of-xpg-gene-rs751402-polymorphism-with-gastric-cancer-risk-a-meta-analysis-in-the-chinese-population
#10
Jun Liang, Ya-Yun Xu, Cheng Zhang, Qing-Rong Xia
BACKGROUND: Previous studies have revealed a conflicting relationship of xeroderma pigmentosum group G (XPG) gene polymorphism with gastric cancer (GC) risk. To our knowledge, this is the first meta-analysis to investigate the association between rs751402 mutation located on the XPG promoter region and GC risk. METHODS: We undertook a meta-analysis by identifying relevant articles from the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) databases on February 28, 2017...
November 9, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/29147877/efficacy-and-safety-of-fully-covered-self-expanding-metal-stents-for-malignant-esophageal-obstruction
#11
Hoonsub So, Ji Yong Ahn, Seungbong Han, Kyoungwon Jung, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jeong, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung
BACKGROUND: Malignant dysphagia can result in poor nutritional status with severe weight loss. Rapid relief from dysphagia can be achieved with esophageal self-expanding metal stents (SEMSs), a minimally invasive method. In this study, we evaluated the usefulness of SEMSs for malignant dysphagia. METHODS: Between 2012 and 2015, 119 patients with malignant dysphagia underwent esophageal SEMS insertion with endoscopic assistance. Their demographics and clinical outcomes were collected...
November 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29147601/tumor-infiltrating-%C3%AE-%C3%AE-t-cells-predict-prognosis-and-adjuvant-chemotherapeutic-benefit-in-patients-with-gastric-cancer
#12
Jieti Wang, Chao Lin, He Li, Ruochen Li, Yifan Wu, Hao Liu, Heng Zhang, Hongyong He, Weijuan Zhang, Jiejie Xu
Purpose : Tumor-infiltrating γδT cells (γδTILs) have different prognostic value and functions among various cancers. The aim of the present study was to evaluate the effect of γδTILs in gastric cancer. Patients and methods : A discovery set (n = 190) and a validation set (n = 273) were involved in this study. Patients with TNM II and III disease were used to predict response to 5-fluorouracil (5-FU)-based adjuvant chemotherapy (ACT) in both sets. γδTILs were defined as intense (γδT cells≥ 5/HPF) versus nonintense (γδT cells<5/HPF)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29141465/reliability-of-rapid-urease-test-for-screening-gastric-cancer-in-high-risk-populations
#13
Negin Kashani, Amin Talebi Bezmin Abadi
No abstract text is available yet for this article.
November 16, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29139048/high-adherence-to-the-western-prudent-and-mediterranean-dietary-patterns-and-risk-of-gastric-adenocarcinoma-mcc-spain-study
#14
Adela Castelló, Nerea Fernández de Larrea, Vicente Martín, Verónica Dávila-Batista, Elena Boldo, Marcela Guevara, Víctor Moreno, Gemma Castaño-Vinyals, Inés Gómez-Acebo, Guillermo Fernández-Tardón, Rosana Peiró, Rocío Olmedo-Requena, Rocio Capelo, Carmen Navarro, Silvino Pacho-Valbuena, Beatriz Pérez-Gómez, Manolis Kogevinas, Marina Pollán, Nuria Aragonés
BACKGROUND: The influence of dietary habits on the development of gastric adenocarcinoma is not clear. The objective of the present study was to explore the association of three previously identified dietary patterns with gastric adenocarcinoma by sex, age, cancer site, and morphology. METHODS: MCC-Spain is a multicase-control study that included 295 incident cases of gastric adenocarcinoma and 3040 controls. The association of the Western, Prudent, and Mediterranean dietary patterns-derived in another Spanish case-control study-with gastric adenocarcinoma was assessed using multivariable logistic regression models with random province-specific intercepts and considering a possible interaction with sex and age...
November 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29137439/association-between-alcohol-consumption-and-the-risk-of-gastric-cancer-a-meta-analysis-of-prospective-cohort-studies
#15
Zheng He, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Zhong-Ran Ni, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao
Alcohol consumption is inconsistently associated with the risk of gastric cancer morbidity and mortality. The aim of this study was to systematically evaluate the association between alcohol consumption on gastric cancer risk. The PubMed, Embase, and Cochrane Library databases were searched from inception through April 2017. Prospective cohort studies evaluating the association between alcohol consumption and risk of gastric cancer which report its effect estimates with 95% confidence intervals (CIs) were included...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137337/alcohol-consumption-and-gastric-cancer-risk-a-meta-analysis-of-prospective-cohort-studies
#16
Xue Han, Li Xiao, Yao Yu, Yu Chen, Hai-Hua Shu
We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose-response relationship between gastric cancer risk and alcohol consumption...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137312/neurofibromatosis-type-1-is-a-prognostic-indicator-in-human-gastric-carcinoma
#17
Debao Liu, Yueying Zhang, Yan Li, Kaixi Fan
We investigated whether the Neurofibromatosis type-1(NF1) gene was of prognostic relevance to gastric cancer (GC) patients. Immunohistochemical staining of 160 matched GC tumor and adjacent normal tissue samples showed that 58.1% (93/160) of GC samples were NF1-positive as compared to 94.4% (151/160) of normal tissue samples (χ(2)=58.05, P <0.001). qRT-PCR analysis revealed that NF1 mRNA expression is lower in GC tissues than normal tissues (χ(2)=34.23, P <0.001). Moreover, NF1 protein and mRNA levels were associated with T stage (P <0...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137273/programmed-death-ligand-1-and-met-co-expression-is-a-poor-prognostic-factor-in-gastric-cancers-after-resection
#18
Mi Jung Kwon, Kab-Choong Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Hye Kyung Lee, Ho Suk Kang, Kyueng-Whan Min
Programmed death-ligand 1 (PD-L1) plays an essential protein for immune evasion, contributing to tumor development and progression. Recent studies have reported MET as an upregulator for PD-L1 overexpression through an oncogenic pathway. However, an association between PD-L1 expression with MET has not been reported in gastric cancer.The prognostic significance of PD-L1 and its association with Epstein-Barr virus (EBV), microsatellite instability (MSI), and mucin phenotype remain controversial. We performed in situ hybridization for EBV-encoded RNA and immunohistochemistry in tissue microarrays for 394 gastric cancers...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136725/-the-china-expert-consensus-of-clinical-practice-for-magnetically-controlled-capsule-gastroscopy-2017-shanghai
#19
(no author information available yet)
Gastric diseases are very common in China, especially gastric cancer with a continuous high level of morbidity and mortality. As an important screening method of gastric diseases, magnetically-controlled-capsule-gastroscopy (MCCG) has already been widely used in medical institutions worldwide. Several clinical trials have already showed that MCCG has comparable accuracy in diagnosing gastric diseases compared with conventional gastroscopy. Furthermore, MCCG has the advantages of anesthesia free, no risks of cross infection, and excellent compliance...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29133255/high-prevalence-of-barrett-s-esophagus-and-esophageal-squamous-cell-carcinoma-after-repair-of-esophageal-atresia
#20
Floor W T Vergouwe, Hanneke IJsselstijn, Katharina Biermann, Nicole S Erler, René M H Wijnen, Marco J Bruno, Manon C W Spaander
BACKGROUND & AIMS: Esophageal atresia is rare, but improved surgical and intensive care techniques have increased rates of survival in children, so there are now many adults with this disorder. Many patients with esophageal atresia develop gastroesophageal reflux (GER), raising concerns about increased risk of Barrett's esophagus (BE; prevalence of 1.3%-1.6% in general population) and esophageal carcinoma. We assessed the prevalence of BE and esophageal carcinoma in this population. METHODS: We performed a prospective study of 289 patients with esophageal atresia at the Department of Gastroenterology and Hepatology at Erasmus MC University Medical Center in The Netherlands, from May 2012 through March 2017...
November 10, 2017: Clinical Gastroenterology and Hepatology
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