Rongchen Ye, Sige Ma, Yan Chen, Jiarou Shan, Ledong Tan, Liang Su, Yanlu Tong, Ziyang Zhao, Hongjiao Chen, Ming Fu, Zhipeng Guo, Xiaoyu Zuo, Jiakang Yu, Wei Zhong, Jixiao Zeng, Fei Liu, Chenwei Chai, Xisi Guan, Zhe Wang, Tao Liu, Jiankun Liang, Yan Zhang, Hongguang Shi, Zhe Wen, Huimin Xia, Ruizhong Zhang
BACKGROUND & AIMS: Our previous study indicated that CD177+ neutrophil activation has a vital role in the pathogenesis of biliary atresia (BA), which is partially ameliorated by N -acetylcysteine (NAC) treatment. Here, we evaluated the clinical efficacy of NAC treatment and profiled liver-resident immune cells via single cell RNA-sequencing (scRNA-seq) analysis to provide a comprehensive immune landscape of NAC-derived immune regulation. METHODS: A pilot clinical study was conducted to evaluate the potential effects of intravenous NAC treatment on infants with BA, and a 3-month follow-up was carried out to assess treatment efficacy...
November 2023: JHEP reports: innovation in hepatology