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Adenoids in children

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https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#1
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29161199/intranasal-budesonide-and-quality-of-life-in-pediatric-sleep-disordered-breathing-a-randomized-controlled-trial
#2
Gunnhildur Gudnadottir, Eva Ellegård, Johan Hellgren
Objective To study the efficacy of budesonide nasal spray on the health-related quality of life and symptoms among children with sleep-disordered breathing. Study Design Randomized, parallel, double-blind, placebo-controlled trial. Setting Tertiary referral center. Subjects and Methods Sixty children (ages, 4-10 years) who were referred because of snoring and/or apneas for >3 months were included between January 2015 and June 2016 and randomized in a double-blind design to treatment with 64 μg/mL of budesonide nasal spray (n = 30) or placebo nasal spray (n = 30) twice daily for 6 weeks...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29153763/prevalence-of-adenoid-hypertrophy-a-systematic-review-and-meta-analysis
#3
REVIEW
Lara Pereira, John Monyror, Fabiana T Almeida, Fernanda R Almeida, Eliete Guerra, Carlos Flores-Mir, Camila Pachêco-Pereira
The purpose of our review was to synthesize the existing literature about the prevalence of adenoid hypertrophy (AH) in children and adolescents confirmed by the reference standard - the nasoendoscopy (NE). Six electronic databases and partial grey literature were searched. Studies were included if they reported the prevalence of AH confirmed via NE. Studies involving participants with associated comorbidities and/or fully diagnosed sleep apnea in their sample were excluded. The MAStARI tool assessed the potential risk of bias (RoB) among the studies, while the GRADE approach determined the level of evidence...
June 14, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29152748/comparison-of-pediatric-adenoidectomy-techniques
#4
Phayvanh P Sjogren, Andrew J Thomas, Benjamin N Hunter, James Butterfield, Craig Gale, Jeremy D Meier
OBJECTIVES: Evaluate the effects of electrocautery, microdebrider, and coblation techniques on outpatient pediatric adenoidectomy costs and complications. STUDY DESIGN: Observational retrospective cohort study. METHODS: An observational cohort study was performed in a multihospital network using a standardized accounting system. Children < 18 years of age who underwent outpatient adenoidectomy were included from January 2008 to September 2015...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29146888/halitosis-in-children-with-adenoid-hypertrophy
#5
Małgorzata Sikorska-Żuk, Marek Bochnia
This paper attempts to identify the sources and evaluate the prevalence of halitosis in children with adenoid hypertrophy. The study included pediatric patients admitted for adenoidectomy due to obstructive symptoms. Patients with possibly other causes of halitosis, were excluded from the study. Halitosis was detected in 30 out of 136 children (22.1%). The effect of adenoid hypertrophy on halitosis was confirmed by the significant reduction in the organoleptic score rated according to the Rosenberg Scale (on average by 2 degrees) and the levels of volatile sulfur compounds (VSCs) (on average 84 ppb) post-adenoidectomy, as compared to pre-surgery results...
November 17, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29138740/pediatric-pulmonary-hemorrhage-vs-extrapulmonary-bleeding-in-the-differential-diagnosis-of-hemoptysis
#6
Michael Vaiman, Baruch Klin, Noa Rosenfeld, Ibrahim Abu-Kishk
Introduction: Hemoptysis is an important symptom which causes a major concern, and warrants immediate diagnostic attention. The authors compared a group of patients with pediatric pulmonary hemorrhage with pediatric patients diagnosed with extrapulmonary bleeding focusing on differences in etiology, outcome and differential diagnosis of hemoptysis. Methods: We performed the retrospective analysis of medical charts of 134 pediatric patients admitted to the Emergency Department because of pulmonary and extrapulmonary hemorrhage and were diagnosed with suspected hemoptysis or developed hemoptysis (ICD10-CM code R04...
2017: Central Asian Journal of Global Health
https://www.readbyqxmd.com/read/29119714/cross-cultural-adaptation-and-validation-of-the-spanish-version-of-the-paediatric-throat-disorders-outcome-test-t-14
#7
Francisco Larrosa, Laura Samara, Eduard Esteller, Maria J Dura, Yolanda Escamilla, Anna Alberti, Rosa Rosell, Claire Hopkins
OBJECTIVES: The Paediatric Throat Disorders Outcome Test (T-14) is a disease-specific questionnaire that parents are requested to complete; it aims to assess the quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the T-14, thus allowing comparison across studies and facilitating international multicentre projects. DESIGN, SETTING AND PARTICIPANTS: This was a multicentre prospective instrument validation study...
November 9, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29110575/utility-of-neck-height-and-tonsillar-size-to-screen-for-obstructive-sleep-apnea-among-obese-youth
#8
Indra Narang, Suhail Al-Saleh, Reshma Amin, Evan J Propst, Saadoun Bin-Hasan, Paolo Campisi, Clodagh Ryan, Tetyana Kendzerska
Objectives To determine whether neck:height ratio combined with adenoid and tonsillar size is a good predictive tool for obstructive sleep apnea in obese youth. Study Design Cross-sectional study. Setting Sleep clinics at the Hospital for Sick Children, Toronto, Canada. Subjects and Methods Consented obese individuals aged 8 to 18 years were recruited between 2013 and 2015. Anthropometric measures were obtained by a trained research coordinator in a standardized manner. Otolaryngologists evaluated adenoid and tonsil sizes...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29092747/pediatric-airway-study-endoscopic-grading-system-for-quantifying-tonsillar-size-in-comparison-to-standard-adenotonsillar-grading-systems
#9
Neha A Patel, Kristen Carlin, Joseph M Bernstein
SIGNIFICANCE: Current grading systems may not allow clinicians to reliably document and communicate adenotonsillar size in the clinical setting. A validated endoscopic grading system may be useful for reporting tonsillar size in future clinical outcome studies. This is especially important as tonsillar enlargement is the cause of a substantial health care burden on children. OBJECTIVE: To propose and validate an easy-to-use flexible fiberoptic endoscopic grading system that provides physicians with a more accurate sense of the three-dimensional relationship of the tonsillar fossa to the upper-airway...
October 29, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29064308/systematic-review-of-drug-induced-sleep-endoscopy-scoring-systems
#10
Janine M Amos, Megan L Durr, Heather C Nardone, Cristina M Baldassari, Angela Duggins, Stacey L Ishman
Objective To systematically review the scoring systems used to report findings during drug-induced sleep endoscopy (DISE) for adults and children with obstructive sleep apnea. Data Sources PubMed, CINAHL, EBM Reviews, Embase, and Scopus databases. Review Methods This is a systematic review of all indexed years of publications referring to scoring of DISE for children and adults with obstructive sleep apnea. The type of DISE scoring system utilized was the primary outcome. PRISMA guidelines were followed to carry out this review; articles were independently reviewed by 2 investigators...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29049225/factors-related-to-pediatric-obstructive-sleep-apnea-hypopnea-syndrome-in-children-with-attention-deficit-hyperactivity-disorder-in-different-age-groups
#11
Jiali Wu, Meizhen Gu, Shumei Chen, Wei Chen, Kun Ni, Hongming Xu, Xiaoyan Li
This study aimed to retrospectively investigate the factors related to pediatric obstructive sleep apnea-hypopnea syndrome (OSAHS) with attention deficit hyperactivity disorder (ADHD) in children younger than 6 years and those older than 6 years.A total of 437 children who were hospitalized due to OSAHS between January 2014 and December 2014 were retrospectively reviewed. The children were further divided into OSAHS group and OSAHS + ADHD group. The general characteristics, OSA-18 quality of life, intention-hyperactivity score, and polysomnographic parameters (apnea-hypopnea index and the lowest oxygen saturation) were collected and compared between groups...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29042788/decreased-frequency-of-adenoidectomy-by-a-12-week-nasal-budesonide-treatment
#12
Haiyu Hong, Fenghong Chen, Xiaobin Zheng, Wei Liao, Zhenpeng Liao, Yujie Cao, Haixin He, Zhe Zhu, Yunping Fan
OBJECTIVE: There is little evidence on the role of topical budesonide in reducing the frequency of adenoidectomy, although it was reported that topical budesonide can effectively ameliorate the symptoms of adenoid hypertrophy (AH). This study was aimed to investigate the possibility and safety of alternatives to adenoidectomy with a 12-week treatment with nasal budesonide. MATERIALS AND METHODS: One hundred patients with AH were randomized to receive either a double-blind budesonide (1 mg once daily) or placebo treatment for 2 weeks by transnasal nebulization...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29039986/orbital-exenteration-institutional-review-of-evolving-trends-in-indications-and-rehabilitation-techniques
#13
Hayyam Kiratli, İrem Koç
PURPOSE: To determine the changes in indications for orbital exenteration over 20 years and to assess its impact on patient survival. Evolving techniques of rehabilitation of the orbit in our institution were also evaluated. METHODS: This was a retrospective review of hospital records of patients who underwent orbital exenteration from 1995 to 2015 in a tertiary care center. Data extracted included primary location of the tumor, preoperative treatments, interval between initial diagnosis and exenteration, status of surgical margins, presence of metastatic disease, and postoperative survival...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/28990663/adaptation-and-validation-of-the-spanish-version-of-the-tonsil-and-adenoid-health-status-instrument
#14
Laura Samara, Eduard Esteller, Maria J Dura, Miquel Guirao, Alda Cardesin, Michael Stewart, Francisco Larrosa
OBJECTIVES/HYPOTHESIS: The Tonsil and Adenoid Health Status Instrument (TAHSI) is a disease-specific questionnaire, intended for completion by parents, for assessing quality of life related to tonsil and adenoid disease or its treatment in children with throat disorders. The aim of this study was to validate the Spanish adaptation of the TAHSI, thus allowing comparison across studies and international multicenter projects. STUDY DESIGN: Multicenter prospective instrument validation study...
October 9, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28912855/effect-of-transoral-endoscopic-adenoidectomy-on-peripheral-blood-t-lymphocyte-subsets-in-children-with-obstructive-sleep-apnea-hypopnea-syndrome-and-its-treatment-strategy
#15
Na Yang, Yaofeng Ji, Yin Liu
The objective of the present study was to investigate the effect of transoral endoscopic adenoidectomy on peripheral blood T lymphocyte subsets in pediatric patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and its treatment strategy. Ninety-eight pediatric patients with adenoidal hypertrophy associated with OSAHS admitted to the Department of Otolaryngology, Xuzhou Children's Hospital were selected. After admission, patients received perfected 24 h polysomnogram monitoring, routine blood examination, fasting blood biochemistry examination, T-lymphocyte subset count, 24 h ambulatory blood pressure monitoring, and nasopharyngeal computed tomography...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28899547/linear-dimensions-of-normal-upper-airway-structure-by-magnetic-resonance-imaging-in-chinese-han-infants-and-preschool-children
#16
Xiaoli Yi, Linyin Yao, Xinyu Yuan, Yongxiang Wei, Zhenchang Wang
OBJECTIVES: To establish normative data of upper airway structure in Chinese Han infants and preschool children. METHODS: Magnetic resonance imaging (MRI) scans of 521 Chinese Han infants and preschool children (225 girls, 296 boys) aged from 1 day to 72 months were selected from the children who underwent head MRI at the Capital Institute of Pediatrics Affiliated Children Hospital, Beijing, China. No subjects had sleep-disordered breathing or associated conditions that may have affected the upper airway anatomy...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28857989/albuminuria-in-pediatric-patients-with-adenotonsillar-hypertrophy
#17
Ozlem Unsal, Gulpembe Bozkurt, Meltem Esen Akpinar, Egehan Salepci, Gokce Aktas Oguz, Berna Uslu Coskun
The relationship between intermittent nocturnal hypoxia and albuminuria in pediatric patients with adenotonsillar hypertrophy was evaluated in this prospective study. Fifty children with grade 3 to 4 adenotonsillar hypertrophy scheduled for adenoidectomy and/or adenotonsillectomy were selected for study group. Fifteen patients with adenotonsillar grade 1 to 2 or adenotonsillectomized subjects in a similar range of sex, age, and body mass index scheduled for other surgeries were selected for control group. All children were monitored using finger pulse oximeter during the night before surgery...
October 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28851993/differential-changes-in-the-adenoids-and-tonsils-in-japanese-children-and-teenagers-a-cross-sectional-study
#18
Asuka Manabe, Takayoshi Ishida, Hyung Sik Yoon, Shin-Sheng Yang, Eiichiro Kanda, Takashi Ono
When adenoids (Ad) and tonsils (Tn) become hypertrophied, craniofacial and general body growth is affected. However, there are no objective explicit criteria for evaluating the size of the Ad and Tn, and their respective growth patterns remain unclear. This study determined the average proportions of the Ad and Tn sizes to the upper airway area at various developmental stages in Japanese individuals. Lateral cephalometric radiographs were obtained from 300 Japanese children and teenagers (150 boys and 150 girls, aged 6-20 years), and the respective proportions of Ad to the nasopharynx (Ad/Np) and Tn to the oropharynx (Tn/Op) in the upper airway were determined...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28818510/breathing-mode-influence-on-craniofacial-development-and-head-posture
#19
Annel Chambi-Rocha, Maria Eugenia Cabrera-Domínguez, Antonia Domínguez-Reyes
OBJECTIVE: The incidence of abnormal breathing and its consequences on craniofacial development is increasing, and is not limited to children with adenoid faces. The objective of this study was to evaluate the cephalometric differences in craniofacial structures and head posture between nasal breathing (NB) and oral breathing (OB) children and teenagers with a normal facial growth pattern. METHOD: Ninety-eight 7-16 year-old patients with a normal facial growth pattern were clinically and radiographically evaluated...
August 14, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28807075/relationship-between-chronic-otitis-media-with-effusion-and-overweight-or-obesity-in-children
#20
S Kaya, E Selimoğlu, S Cureoğlu, M A Selimoğlu
OBJECTIVES: Otitis media with effusion and obesity are both common in childhood and might share some immunological alterations. This study aimed to investigate the relationship between chronic otitis media with effusion and childhood overweight or obesity, including the potential effects of adenoid or tonsillar hypertrophy on that relationship. METHODS: This study included 60 children with chronic otitis media with effusion and 86 healthy children aged from 2 to 10 years...
October 2017: Journal of Laryngology and Otology
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