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https://www.readbyqxmd.com/read/29244742/fibrinogen-gamma-chain-mutations-provoke-fibrinogen-and-apolipoprotein-b-plasma-deficiency-and-liver-storage
#1
Francesco Callea, Isabella Giovannoni, Sinan Sari, Esendagli Guldal, Buket Dalgic, Gulen Akyol, Tsuyoshi Sogo, Abdulrahman Al-Hussaini, Giuseppe Maggiore, Andrea Bartuli, Renata Boldrini, Paola Francalanci, Emanuele Bellacchio
p.R375W (Fibrinogen Aguadilla) is one out of seven identified mutations (Brescia, Aguadilla, Angers, Al du Pont, Pisa, Beograd, and Ankara) causing hepatic storage of the mutant fibrinogen γ. The Aguadilla mutation has been reported in children from the Caribbean, Europe, Japan, Saudi Arabia, Turkey, and China. All reported children presented with a variable degree of histologically proven chronic liver disease and low plasma fibrinogen levels. In addition, one Japanese and one Turkish child had concomitant hypo-APOB-lipoproteinemia of unknown origin...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29243516/gas6-as-a-predictor-of-esophageal-varices-in-patients-affected-by-hepatitis-c-virus-related-chronic-liver-disease
#2
Mattia Bellan, Pier Paolo Sainaghi, Margherita Tran Minh, Rosalba Minisini, Luca Molinari, Marco Baldrighi, Livia Salmi, Matteo Nazzareno Barbaglia, Luigi Mario Castello, Paolo Ravanini, Gian Carlo Avanzi, Mario Pirisi
AIM: Plasma Gas6 was tested as an alternative to Baveno VI criteria (liver stiffness <20 kPa and platelet count >150 × 109/l) in an endoscopy-sparing strategy. METHODS:  A total of 160 patients with chronic hepatitis C and advanced fibrosis/cirrhosis underwent, on the same occasion, liver elastography, upper endoscopy, a platelet count and serum Gas6 measurement Results: A total of 74/160 (46%) patients had esophageal varices, that were small (diameter <5 mm) in 57/160 (34%) and large in 17/160 (11%) cases...
December 15, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29243418/-research-progress-of-pharmacokinetics-and-pharmacodynamics-of-total-glucosides-of-peony-in-hepatoprotective-effects
#3
REVIEW
Zhi-Yan Zuo, Shu-Yu Zhan, Xuan Huang, Bao-Yue Ding, Yu-Qian Liu, Yu-Er Ruan, Ning-Hua Jiang
Total glucosides of peony (TGP), containing the effective components of paeoniflorin (Pae), albiflorin (Alb) and so on, are effective parts of Radix Paeoniae Alba. And it possesses extensive pharmacological actions, one of which is hepatoprotective effect. In recent years, abundant of pharmacokinetics and pharmacodynamics research of TGP in hepatoprotective effects have been performed. However, the relative medicine of TGP in hepatoprotective effect has not been developed for clinical application. In order to provide reference for the development and rational clinical application of TGP, the research progresses of pharmacokinetics and pharmacodynamics of TGP in hepatoprotective effect were summarized in this paper...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29242513/scarf-1-promotes-adhesion-of-cd4-t-cells-to-human-hepatic-sinusoidal-endothelium-under-conditions-of-shear-stress
#4
Daniel A Patten, Sivesh K Kamarajah, Joanne M Rose, Joseph Tickle, Emma L Shepherd, David H Adams, Chris J Weston, Shishir Shetty
Liver-resident cells are constantly exposed to gut-derived antigens via portal blood and, as a consequence, they express a unique repertoire of scavenger receptors. Whilst there is increasing evidence that the gut contributes to chronic inflammatory liver disease, the role of scavenger receptors in regulating liver inflammation remains limited. Here, we describe for the first time the expression of scavenger receptor class F, member 1 (SCARF-1) on hepatic sinusoidal endothelial cells (HSEC). We report that SCARF-1 shows a highly localised expression pattern and co-localised with endothelial markers on sinusoidal endothelium...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241748/psoriasis-and-the-metabolic-syndrome
#5
Paolo Gisondi, Anna Chiara Fostini, Irene Fossà, Giampiero Girolomoni, Giovanni Targher
Chronic plaque psoriasis is an immune-mediated inflammatory skin disease that is strongly associated with the clinical features of the metabolic syndrome (MetS), including abdominal obesity, hypertension, atherogenic dyslipidemia, type 2 diabetes, insulin resistance, and nonalcoholic fatty liver disease. The strength of these associations has been repeatedly confirmed by several observational studies. In particular, the prevalence of MetS in patients with psoriasis ranges from 20% to 50%, with a risk of having MetS is at least double in psoriatic patients compared with nonpsoriatic control individuals...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29240010/well-preserved-renal-function-in-children-with-untreated-chronic-liver-disease
#6
Ulla B Berg, Antal Németh
OBJECTIVES: Based on studies with hepatorenal syndrome, it is widely regarded that renal function is impacted in chronic liver disease. Therefore we investigated renal function in our children with chronic liver disease. METHODS: In a retrospective study of 277 children with chronic liver disease, renal function was investigated as glomerular filtration rate (GFR) and effective renal plasma flow (ERPF), measured as clearance of inulin and para-amino hippuric acid or clearance of iohexol...
December 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29238510/epidemiology-transmission-diagnosis-and-outcome-of-hepatitis-c-virus-infection
#7
REVIEW
Seyed Hamid Moosavy, Parivash Davoodian, Mirza Ali Nazarnezhad, Abdolazim Nejatizaheh, Ebrahim Eftekhar, Hamidreza Mahboobi
Hepatitis C infection is one of the main causes of chronic liver disorders worldwide. Nearly three percent (3%) of the world population has an HCV infection. Prevalence of HCV infection was higher in some groups such as injected drug users (IDUs) and HIV positive populations. Acute hepatitis has proven asymptomatic in most cases, and delay of diagnosis might lead to late onset of hepatocellular carcinoma and cirrhosis. Some host characteristics such as age, gender, body mass index, and viral properties are associated with HCV outcome hepatitis...
October 2017: Electronic Physician
https://www.readbyqxmd.com/read/29238003/direct-acting-agents-for-hepatitis-c-virus-before-and-after-liver-transplantation
#8
Yasuhiko Sugawara, Taizo Hibi
Chronic hepatitis C virus (HCV) infection remains a widespread public health concern and many people are infected with HCV. HCV is one of the leading indications for liver transplantation. Direct-acting antiviral agents (DAAs) against HCV have changed the course of chronic HCV infection, however, making it a curable disease. DAA treatment may be initiated before or after liver transplantation. In the present review, we present the available data on DAA treatment of HCV in liver transplant recipients.
December 14, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/29237409/iga-nephropathy-featuring-massive-wire-loop-like-deposits-in-two-patients-with-alcoholic-cirrhosis
#9
Daisuke Takada, Keiichi Sumida, Akinari Sekine, Ryo Hazue, Masayuki Yamanouchi, Tatsuya Suwabe, Noriko Hayami, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Yoshifumi Ubara
BACKGROUND: Various renal manifestations are known to develop in patients with liver disease, including chronic hepatitis and cirrhosis. CASE PRESENTATION: We evaluated renal disease in two 47-year-old Japanese men with liver cirrhosis and chronic alcoholism for 34 years and 27 years, respectively. Renal biopsy demonstrated massive wire loop-like deposits in the subendothelial space of the glomerular basement membrane and in the mesangium. However, immunofluorescence was only positive for IgA and C3, and electron microscopy did not reveal any organized structures in the electron-dense deposits...
December 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29236915/prognostic-factors-of-the-short-term-outcomes-of-patients-with-hepatitis-b-virus-associated-acute-on-chronic-liver-failure
#10
Qing Lei, Kangjian Ao, Yinhua Zhang, Deqiang Ma, Deping Ding, Changzheng Ke, Yue Chen, Jie Luo, Zhongji Meng
OBJECTIVE: To investigate the impact of the baseline status of patients with hepatitis B virus-associated acute-on-chronic liver failure on short-term outcomes. METHODS: A retrospective study was conducted that included a total of 138 patients with hepatitis B virus-associated acute-on-chronic liver failure admitted to the Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, from November 2013 to October 2016. The patients were divided into a poor prognosis group (74 patients) and a good prognosis group (64 patients) based on the disease outcome...
November 2017: Clinics
https://www.readbyqxmd.com/read/29236317/association-of-rno-mir-183-96-182-cluster-with-diethylnitrosamine-induced-liver-fibrosis-in-wistar-rats
#11
Rajeev Chandel, Roli Saxena, Ashim Das, Jyotdeep Kaur
Chronic liver injury due to various etiological factors including environmental carcinogens results in development of liver fibrosis. Numerous studies showed role of miRNAs in liver fibrosis. In the present study, we determined the rno-miR-183-96-182 cluster expression during hepatic fibrosis induced by diethylnitrosamine (DEN) treated Wistar rats and its association with plasma levels of circulating rno-miR-96, rno-miR-182, rno-miR-183, liver function test and lipid profile, aiming to identify their potential for histological stratification and early diagnosis of liver fibrosis...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29235656/nonalcoholic-fatty-liver-disease-in-patients-with-psoriasis-a-consequence-of-systemic-inflammatory-burden
#12
REVIEW
R B Prussick, L Miele
Patients with psoriasis are at an increased risk for nonalcoholic fatty liver disease (NAFLD) compared to the general population. However, the pathophysiology underlying this comorbidity and elucidation of effective treatment strategies are unclear. This review provides insights into the possible role of chronic, low-grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Both conditions are associated with increased levels of pro-inflammatory adipokines (such as tumor necrosis factor-α and interleukin-6), and hepatokines, and decreased levels of adiponectin, an anti-inflammatory adipokine...
December 13, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29234972/staging-treatment-and-future-approaches-of-gallbladder-carcinoma
#13
REVIEW
Sanjeev Kumar Shukla, Govind Singh, K S Shahi, Bhuvan, Prabhat Pant
BACKGROUND: Gallbladder cancer is the most common malignant cancer of the bile ducts and third most common gastrointestinal malignant in the world for public health. Its relatively low incidence and confused symptoms result in advanced disease at the time of presentation, contributing to poor prognosis and reduced survival associated with this disease. The main function of the gallbladder is to store excreted bile acids from the liver in preparation for a meal. Its main risk factor is prolonged exposure to biliary calculations, although bacterial infections and other inflammatory conditions are associated...
December 12, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29234288/lipocalin-2-in-fructose-induced-fatty-liver-disease
#14
Jessica Lambertz, Thorsten Berger, Tak W Mak, Josef van Helden, Ralf Weiskirchen
The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ. However, precisely how fructose is involved in NAFLD progression is still not fully understood, limiting therapy. Lipocalin-2 (LCN2) is a small secreted transport protein that binds to fatty acids, phospholipids, steroids, retinol, and pheromones. LCN2 regulates lipid and energy metabolism in obesity and is upregulated in response to insulin...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29234199/prevalence-and-characteristics-of-hepatitis-delta-virus-infection-in-a-tertiary-hospital-setting-in-cameroon
#15
Henry N Luma, Servais A F B Eloumou, Cécile Okalla, Olivier Donfack-Sontsa, Ruth Koumitana, Agnes Malongue, Georges B Nko'Ayissi, Dominique N Noah
Background/Aims: Hepatitis B virus (HBV) and hepatitis D virus (HDV) coinfection is associated with more severe liver disease than HBV alone. More knowledge on the epidemiology and clinical impact of HDV-infected individuals is needed in Cameroon.We aimed at determining the frequency of anti-HDV antibody testing in hepatitis B surface antigen (HBsAg) positive patients, the proportion of anti-HDV positivity, and the characteristics of anti-HDV positive compared to anti-HDV negative patients in a tertiary hospital setting in Cameroon...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29234194/an-insight-into-antibiotic-resistance-to-bacterial-infection-in-chronic-liver-disease
#16
Mayank Jain, Joy Varghese, Tom Michael, Chandan Kumar Kedarishetty, Balajee G, Subramanian Swaminathan, Jayanthi Venkataraman
Background: End stage liver disease leads to immune dysfunction which predisposes to infection. There has been a rise in antibiotic resistant infections in these patients. There is scanty data f from India or idea regarding the same. Aim of the study: The present study was undertaken to determine the type of infection acquired and the prevalence of antibiotic resistant infections in cirrhotic patients at a tertiary referral center in South India. Materials and methods: In this retrospective study, all consecutive cirrhotic patients hospitalized between 2011 and 2013 with a microbiologically-documented infection were enrolled...
December 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29233630/higher-risk-of-renal-disease-in-chronic-hepatitis-c-patients-antiviral-therapy-survival-benefit-in-patients-on-hemodialysis
#17
Jonas Söderholm, Charlotta Millbourn, Katharina Büsch, Jan Kövamees, Robert Schvarcz, Karin Lindahl, Annette Bruchfeld
BACKGROUND & AIMS: Several studies have shown that chronic hepatitis C (CHC) infection has a negative impact on kidney function, as well as survival, in patients with chronic kidney disease (CKD) or on hemodialysis (HD). The aim of this nationwide registry study was to describe renal disease in Swedish CHC patients METHODS: In the present study, patients were identified for CHC (B18.2) and CKD (N18) according to the International Classification of Diseases (ICD)-10 in the nationwide Swedish inpatient care day surgery (1997-2013) and non-primary outpatient care (2001-2013) patient registries...
December 9, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29233599/corrigendum-to-multidisciplinary-approach-to-optimize-management-of-patients-with-chronic-hepatitis-c-and-alcoholic-liver-disease-j-formos-med-assoc-2016-1097-1098
#18
Yi-Wen Huang
No abstract text is available yet for this article.
December 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29231919/-non-alcoholic-liver-disease-diagnosis-and-treatment
#19
REVIEW
Anna Sarosiekjeznach-Steinhagen, Joanna Ostrowska, Aneta Czerwonogrodzka-Senczyna, Iwona Boniecka
Non-alcoholic fatty liver disease (NAFLD) is currently the most common chronic liver disease in the developed world (15% to 40% of the adult population). Introduction of lifestyle changes including dietary intervention and increased physical activity is most often the first-line treatment and is intended to support not only the treatment of liver disease, but also for diseases associated with obesity, insulin resistance, diabetes and dyslipidemia. In addition to well-known metformin, there are new classes of antidiabetic drugs, including GLP-1analog, SGLT-2 antagonist, pioglitazon...
November 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29230534/the-burden-of-comorbidity-and-complexity-in-sarcoidosis-impact-of-associated-chronic-diseases
#20
Pilar Brito-Zerón, Nihan Acar-Denizli, Antoni Sisó-Almirall, Xavier Bosch, Fernanda Hernández, Sergi Vilanova, Mireia Villalta, Belchin Kostov, Marina Paradela, Marcelo Sanchez, José Ramírez, Africa Muxí, Antonio Berruezo, Celeste Galceran-Chaves, Antoni Xaubet, Carles Agustí, Jacobo Sellarés, Manuel Ramos-Casals
PURPOSE: To evaluate comorbidity, complexity and poor outcomes in patients with sarcoidosis and to compare those scores with a control group. METHODS: 218 consecutive patients were diagnosed with sarcoidosis according to the ATS/ERS/WASOG criteria; extrathoracic involvement was evaluated using the 2014 WASOG organ assessment instrument. Sarcoidosis patients were compared with an age- and gender-matched control group of primary care outpatients without sarcoidosis...
December 11, 2017: Lung
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