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JOURNAL ARTICLE
Kaylee Petraccione, Mohamed G H Ali, Normand Cyr, Haytham M Wahba, Timothy Stocker, Maryna Akhrymuk, Ivan Akhrymuk, Lauren Panny, Nicole Bracci, Raphaël Cafaro, Danuta Sastre, Andrew Silberfarb, Paul O'Maille, James Omichinski, Kylene Kehn-Hall
Rift Valley fever virus (RVFV) is a viral zoonosis that causes severe disease in ruminants and humans. The nonstructural small (NSs) protein is the primary virulence factor of RVFV that suppresses the host's antiviral innate immune response. Bioinformatic analysis and AlphaFold structural modeling identified four putative LC3-interacting regions (LIR) motifs (NSs 1-4) in the RVFV NSs protein, which suggest that NSs interacts with the host LC3-family proteins. Using, isothermal titration calorimetry, X-ray crystallography, co-immunoprecipitation, and co-localization experiments, the C-terminal LIR motif (NSs4) was confirmed to interact with all six human LC3 proteins...
March 21, 2024: PLoS Pathogens
#22
JOURNAL ARTICLE
Juan J Díez, Emma Anda, Begoña Pérez-Corral, Miguel Paja, Victoria Alcázar, Cecilia Sánchez-Ragnarsson, Aida Orois, Ana R Romero-Lluch, Marcel Sambo, Amelia Oleaga, Águeda Caballero, María R Alhambra, Virginia Urquijo, Ana M Delgado-Lucio, José C Fernández-García, Viyey Kishore-Doulatram, Suset Dueñas-Disotuar, Tomás Martín, Mercedes Peinado, Julia Sastre
PURPOSE: Population-based and registry studies have shown that chronic hypoparathyroidism is accompanied by long-term complications. We aimed to evaluate the risk of incident comorbidity among patients with chronic postsurgical hypoparathyroidism in real-life clinical practice in Spain. METHODS: We performed a multicenter, retrospective cohort study including patients with chronic postsurgical hypoparathyroidism lasting ≥3 years with at least a follow-up visit between January 1, 2022 and September 15, 2023 (group H)...
2024: Frontiers in Endocrinology
#23
JOURNAL ARTICLE
Lu Peng, Bogdan Jurca, Alberto Garcia-Baldovi, Liang Tian, German Sastre, Ana Primo, Vasile Parvulescu, Amarajothi Dhakshinamoorthy, Hermenegildo Garcia
The quest for efficient catalysts based on abundant elements that can promote the selective CO2 hydrogenation to green methanol still continues. Most of the reported catalysts are based on Cu/ZnO supported in inorganic oxides, with not much progress with respect to the benchmark Cu/ZnO/Al2 O3 catalyst. The use of carbon supports for Cu/ZnO particles is much less explored in spite of the favorable strong metal support interaction that these doped carbons can establish. This manuscript reports the preparation of a series of Cu-ZnO@(N)C samples consisting of Cu/ZnO particles embedded within a N-doped graphitic carbon with a wide range of Cu/Zn atomic ratio...
March 6, 2024: Nanomaterials
#24
JOURNAL ARTICLE
Luca Bollo, Georgina Arrambide, Alvaro Cobo-Calvo, Javier V Alvarez, Manel Alberich, Sergio Cabello, Joaquín Castilló, Ingrid Galan, Luciana S Midaglia, Breogan Rodriguez Acevedo, Ana Zabalza, Agustin Pappolla, Neus Mongay Ochoa, Mar Tintore, Jordi Rio, Manuel Comabella, Carmen Tur, Cristina Auger, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban, Deborah Pareto, Angela Vidal-Jordana
BACKGROUND AND OBJECTIVES: We aimed to assess the presence of retinal neurodegeneration independent of optic neuritis (ON) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to investigate the development of trans-synaptic anterograde degeneration in these patients after ON. METHODS: Cross-sectional, retrospective study of 34 adult patients with MOGAD and 23 healthy controls (HC). Clinical, optical coherence tomography (OCT), and MRI data were collected...
April 9, 2024: Neurology
#25
JOURNAL ARTICLE
Alba Escalera, Amaya Rojo-Fernandez, Alexander Rombauts, Gabriela Abelenda-Alonso, Jordi Carratalà, Adolfo García-Sastre, Teresa Aydillo
Despite multiple research efforts to characterize coronavirus disease 2019 (COVID-19) in humans, there is no clear data on the specific role of mucosal immunity on COVID-19 disease. Here, we longitudinally profile the antibody response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and seasonal HCoV-OC43 S proteins in serum and nasopharyngeal swabs from COVID-19 patients. Results showed that specific antibody responses against SARS-CoV-2 and HCoV-OC43 S proteins can be detected in the upper respiratory tract...
March 15, 2024: IScience
#26
JOURNAL ARTICLE
Alejandro Losada, Nuria Izquierdo-Useros, Pablo Aviles, Júlia Vergara-Alert, Irene Latino, Joaquim Segalés, Santiago F Gonzalez, Carmen Cuevas, Dàlia Raïch-Regué, María J Muñoz-Alonso, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Jordi Rodon, Lauren A Chang, Prajakta Warang, Gagandeep Singh, Marco Brustolin, Guillermo Cantero, Núria Roca, Mònica Pérez, Eugenio Bustos-Morán, Kris White, Michael Schotsaert, Adolfo García-Sastre
Plitidepsin is a host-targeted compound known for inducing a strong anti-SARS-CoV-2 activity, as well as for having the capacity of reducing lung inflammation. Because IL-6 is one of the main cytokines involved in acute respiratory distress syndrome, the effect of plitidepsin in IL-6 secretion in different in vitro and in vivo experimental models was studied. A strong plitidepsin-mediated reduction of IL-6 was found in human monocyte-derived macrophages exposed to nonproductive SARS-CoV-2. In resiquimod (a ligand of TLR7/8)-stimulated THP1 human monocytes, plitidepsin-mediated reductions of IL-6 mRNA and IL-6 levels were also noticed...
February 28, 2024: Journal of Immunology
#27
JOURNAL ARTICLE
Rajiv Pathak, Carolina Eliscovich, Ignacio Mena, Anastasija Cupic, Magdalena Rutkowska, Kartik Chandran, Rohit K Jangra, Adolfo García-Sastre, Robert H Singer, Ganjam V Kalpana
SARS-CoV-2 infection remains a global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood, such as the kinetics of the formation of genomic RNA (gRNA), sub-genomic RNA (sgRNA), and replication centers/organelles (ROs). We employed single-molecule RNA-fluorescence in situ hybridization (smRNA-FISH) to simultaneously detect viral gRNA and sgRNA and immunofluorescence to detect nsp3 protein, a marker for the formation of RO, and carried out a time-course analysis...
February 7, 2024: Viruses
#28
Elena Basabe, José C De La Flor, Virginia López de la Manzanara, Luis Nombela-Franco, Carlos Narváez-Mejía, Leónidas Cruzado, Daniel Villa, Rocío Zamora, Manuel Tapia, Miguel Ángel Sastre, Edurne López Soberón, José A Herrero Calvo, Alfonso Suárez, David Martí Sánchez
Non-valvular atrial fibrillation (NVAF) is the most common cardiac arrhythmia in the general population, and its prevalence increases among patients with chronic kidney disease (CKD) undergoing hemodialysis. This population presents high risk of both hemorrhagic and thrombotic events, with little evidence regarding the use of oral anticoagulation treatment (OAT) and multiple complications arising from it; however, stroke prevention with percutaneous left atrial appendage closure (LAAC) is an alternative to be considered...
January 29, 2024: Medicina
#29
REVIEW
Mateus Boaventura, Jaume Sastre-Garriga, Carolina de Medeiros Rimkus, Àlex Rovira, Deborah Pareto
T1/T2-weighted ratio is a novel magnetic resonance imaging (MRI) biomarker based on conventional sequences, related to microstructural integrity and with increasing use in multiple sclerosis (MS) research. Different from other advanced MRI techniques, this method has the advantage of being based on routinely acquired MRI sequences, a feature that enables analysis of retrospective cohorts with considerable clinical value. This article provides an overview of this method, describing the previous cross-sectional and longitudinal findings in the main MS clinical phenotypes and in different brain tissues: focal white matter (WM) lesions, normal-appearing white matter (NAWM), cortical gray matter (GM), and deep normal-appearing gray matter (NAGM)...
February 22, 2024: Multiple Sclerosis: Clinical and Laboratory Research
#30
JOURNAL ARTICLE
Xuechao Tan, Pablo García-Aznar, German Sastre, Suk Bong Hong
Ammonia selective catalytic reduction (NH3 -SCR) over copper- and iron-exchanged zeolites is a state-of-the-art technology for removal of nitrogen oxides (NO x , NO, and NO2 ) from exhaust emissions but suffers from poor low-temperature (i.e., 150 °C) activity. Here we show that hydrothermal aging of Fe-beta, Fe-ZSM-5, and Fe-ferrierite at 650 °C or higher leads to a remarkable increase in NO x conversion from ∼30 to ∼80% under fast NH3 -SCR conditions at 150 °C. The practical relevance of this finding becomes more evident as an aged Fe-beta/fresh Cu-SSZ-13 composite catalyst exhibits ∼90% conversion...
February 22, 2024: Journal of the American Chemical Society
#31
REVIEW
Maria Sastre, Alessandra Cimbalo, Jordi Mañes, Lara Manyes
The prevalence of diabetes has increased in last decades worldwide and is expected to continue to do so in the coming years, reaching alarming figures. Evidence have shown that patients with type 2 diabetes (T2D) have intestinal microbial dysbiosis. Moreover, several mechanisms link the microbiota with the appearance of insulin resistance and diabetes. Diet is a crucial factor related to changes in the composition, diversity, and activity of gut microbiota (GM). In this review, the current and future possibilities of nutrient-GM interactions as a strategy to alleviate T2D are discussed, as well as the mechanisms related to decreased low-grade inflammation and insulin resistance...
February 2024: Journal of Medicinal Food
#32
JOURNAL ARTICLE
Raúl Velamazán, Pablo López-Guillén, Samuel J Martínez-Domínguez, Daniel Abad Baroja, Daniel Oyón, Anna Arnau, Lara M Ruiz-Belmonte, Javier Tejedor-Tejada, Raul Zapater, Noelia Martín-Vicente, Pedro José Fernández-Esparcia, Ana Belén Julián Gomara, Violeta Sastre Lozano, Juan José Manzanares García, Irene Chivato Martín-Falquina, Laura Andrés Pascual, Nuria Torres Monclus, Natividad Zaragoza Velasco, Eukene Rojo, Berta Lapeña-Muñoz, Virginia Flores, Arantxa Díaz Gómez, Pablo Cañamares-Orbís, Isabel Vinzo Abizanda, Natalia Marcos Carrasco, Laura Pardo Grau, Guillermo García-Rayado, Judith Millastre Bocos, Ana Garcia Garcia de Paredes, María Vaamonde Lorenzo, Arantzazu Izagirre Arostegi, Edgard Efrén Lozada-Hernández, José Antonio Velarde-Ruiz Velasco, Enrique de-Madaria
BACKGROUND: Delayed cholecystectomy in patients with symptomatic gallstone disease is associated with recurrence. Limited data on the recurrence patterns and the factors that determine them are available. OBJECTIVE: We aimed to determine the pattern of relapse in each symptomatic gallstone disease (acute pancreatitis, cholecystitis, cholangitis, symptomatic choledocholithiasis, and biliary colic) and determine the associated factors. METHODS: RELAPSTONE was an international multicenter retrospective cohort study...
February 20, 2024: United European Gastroenterology Journal
#33
REVIEW
Ioana Agache, Carlos Canelo-Aybar, Isabella Annesi-Maesano, Lorenzo Cecchi, Benedetta Biagioni, Fan Chung, Gennaro D'Amato, Athanasios Damialis, Stefano Del Giacco, Leticia De Las Vecillas, Javier Dominguez-Ortega, Carmen Galàn, Stefanie Gilles, Mattia Giovannini, Stephen Holgate, Mohamed Jeebhay, Kari Nadeau, Nikos Papadopoulos, Santiago Quirce, Joaquin Sastre, Claudia Traidl-Hoffmann, Jolanta Walusiak-Skorupa, Bernardo Sousa-Pinto, Josefina Salazar, L Yesenia Rodríguez-Tanta, Yahveth Cantero, Camila Montesinos-Guevara, Yang Song, Giancarlo Alvarado-Gamarra, Ivan Sola, Pablo Alonso-Coello, Wendy Nieto-Gutierrez, Marek Jutel, Cezmi A Akdis
Systematic review using GRADE of the impact of exposure to volatile organic compounds (VOCs), cleaning agents, mould/damp, pesticides on the risk of (i) new-onset asthma (incidence) and (ii) adverse asthma-related outcomes (impact). MEDLINE, EMBASE and Web of Science were searched for indoor pollutant exposure studies reporting on new-onset asthma and critical and important asthma-related outcomes. Ninety four studies were included: 11 for VOCs (7 for incidenceand 4 for impact), 25 for cleaning agents (7 for incidenceand 8 for impact), 48 for damp/mould (26 for incidence and 22 for impact) and 10 for pesticides (8 for incidence and 2 for impact)...
February 17, 2024: Allergy
#34
JOURNAL ARTICLE
Juan Sastre, José Ángel Mínguez, Juan Luis Alcázar, Luis Chiva
OBJECTIVE: Between 20% and 30% of women who have undergone tubal ligation regret their decision. The alternative to regain fertility for these women is either in vitro fertilization or tubal re-anastomosis. This article presents a systematic review with meta-analysis to assess the current evidence on the efficacy of tubal recanalization surgery in patients who have previously undergone tubal ligation. STUDY DESIGN: The search was conducted in the World of Science (WOS) database, The Cochrane Library and ClinicalTrials...
December 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#35
JOURNAL ARTICLE
Huiru Yang, Liang Tian, Abdessamad Grirrane, Alberto García-Baldoví, Jiajun Hu, German Sastre, Changwei Hu, Hermenegildo García
Photodecarboxylation of biomass-derived fatty acids to alkanes offers significant potential to obtain hydrocarbons and economic benefits due to the mild conditions and high activity. Herein, the photodecarboxylation of hexanoic acid into alkanes using TiO2 -supported monometallic Au or Pd and bimetallic Au-Pd catalysts is reported. It was found that bimetallic Au-Pd catalysts, featuring a core-shell structure evidenced by EDX-mapping and element line profile, show better photocatalytic performance, achieving 94...
November 17, 2023: ACS Catalysis
#36
JOURNAL ARTICLE
Sylvia Sastre-Riba
INTRODUCTION: Executive functions and Metacognition are integrated for the management of intellectual resources in close relation to intelligence its functioning and results; they are specially interesting for understanding the expression and development of high intellectual abilility (HIA). The aim of the study is to find out the relationship between executive functions (and components) and metacognition (and components) in schoolchildren with HIA. MATERIALS AND METHOD: Measures of executive and metacognitive functioning and perfectionism were extracted from a sample of n= 147 schoolchildren with HIA...
March 2024: Medicina
#37
JOURNAL ARTICLE
Rosa González-Sastre, Raquel Coronel, Adela Bernabeu-Zornoza, Patricia Mateos-Martínez, Andreea Rosca, Victoria López-Alonso, Isabel Liste
Human cerebral organoids (hCOs) offer the possibility of deepening the knowledge of human brain development, as well as the pathologies that affect it. The method developed here describes the efficient generation of hCOs by going directly from two-dimensional (2D) pluripotent stem cell (PSC) cultures to three-dimensional (3D) neuroepithelial tissue, avoiding dissociation and aggregation steps. This has been achieved by subjecting 2D cultures, from the beginning of the neural induction step, to dual-SMAD inhibition in combination with CHIR99021...
2024: Journal of Tissue Engineering
#38
M Á Gómez-Ríos, J A Sastre, X Onrubia-Fuertes, T López, A Abad-Gurumeta, R Casans-Frances, D Gómez-Ríos, J C Garzón, V Martínez-Pons, M Casalderrey-Rivas, M Á Fernández-Vaquero, E Martínez-Hurtado, R Martín-Larrauri, L Reviriego-Agudo, U Gutierrez-Couto, J García-Fernández, A Serrano-Moraza, L J Rodríguez Martín, C Camacho Leis, S Espinosa Ramírez, J M Fandiño Orgeira, M J Vázquez Lima, M Mayo-Yáñez, P Parente-Arias, J A Sistiaga-Suárez, M Bernal-Sprekelsen, P Charco-Mora
The Airway Management section of the Spanish Society of Anesthesiology, Resuscitation, and Pain Therapy (SEDAR), the Spanish Society of Emergency Medicine (SEMES), and the Spanish Society of Otorhinolaryngology and Head and Neck Surgery (SEORL-CCC) present the Guide for the comprehensive management of difficult airway in adult patients. Its principles are focused on the human factor, cognitive processes for decision-making in critical situations, and optimization in the progression of strategies application to preserve adequate alveolar oxygenation in order to enhance safety and the quality of care...
February 8, 2024: Revista española de anestesiología y reanimación
#39
M Á Gómez-Ríos, J A Sastre, X Onrubia-Fuertes, Teresa López, A Abad-Gurumeta, R Casans-Frances, D Gómez-Ríos, J C Garzón, V Martínez-Pons, M Casalderrey-Rivas, M Á Fernández-Vaquero, E Martínez-Hurtado, R Martín-Larrauri, L Reviriego-Agudo, U Gutierrez-Couto, J García-Fernández, A Serrano-Moraza, L J Rodríguez Martín, C Camacho Leis, S Espinosa Ramírez, J M Fandiño Orgeira, M J Vázquez Lima, M Mayo-Yáñez, P Parente-Arias, J A Sistiaga-Suárez, M Bernal-Sprekelsen, P Charco-Mora
The Airway Management section of the Spanish Society of Anesthesiology, Resuscitation, and Pain Therapy (SEDAR), the Spanish Society of Emergency Medicine (SEMES), and the Spanish Society of Otorhinolaryngology and Head and Neck Surgery (SEORL-CCC) present the Guide for the comprehensive management of difficult airway in adult patients. Its principles are focused on the human factor, cognitive processes for decision-making in critical situations, and optimization in the progression of strategies application to preserve adequate alveolar oxygenation in order to enhance safety and the quality of care...
February 8, 2024: Revista española de anestesiología y reanimación
#40
JOURNAL ARTICLE
Joaquín Cerdá-Boluda, Marta C Mora, Nuria Lloret, Stefano Scarani, Jorge Sastre
The emergence of the Metaverse is raising important questions in the field of human-machine interaction that must be addressed for a successful implementation of the new paradigm. Therefore, the exploration and integration of both technology and human interaction within this new framework are needed. This paper describes an innovative and technically viable proposal for virtual shopping in the fashion field. Virtual hands directly scanned from the real world have been integrated, after a retopology process, in a virtual environment created for the Metaverse, and have been integrated with digital nails...
January 23, 2024: Sensors
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