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https://www.readbyqxmd.com/read/29031890/changing-perspectives-in-atopic-dermatitis
#1
REVIEW
E Serra-Baldrich, J O de Frutos, I Jáuregui, J C Armario-Hita, J F Silvestre, L Herraez, A Martín-Santiago, A Valero, J Sastre
Atopic dermatitis (AD) is a multifaceted disease that involves a complex interplay between the skin and the immune system. The course of the disease depends strongly on the genetic background of the patient and on yet poorly-defined environmental factors. Changes in lifestyle could be behind the dramatic rise in the prevalence of AD across continents; including hygienic conditions, food, social habits, skin microbiome or exposure to a number of allergens. Although AD typically develops in childhood and disappears after a few years, in a relatively large number of patients it continues into adulthood...
October 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29018525/concordance-of-opinions-between-patients-and-physicians-and-their-relationship-with-symptomatic-control-and-future-risk-in-patients-with-moderate-severe-asthma
#2
Astrid Crespo-Lessmann, Vicente Plaza, Francisco-Javier González-Barcala, Toni Fernández-Sánchez, Joaquín Sastre
INTRODUCTION: Differences between the opinions of patients and physicians on the impact of asthma are common. We hypothesised that patient-physician discordance may negatively affect asthma outcome. METHODS: A total of 2902 patients (61% women, mean age 47 years) with moderate-severe asthma and 231 physicians participated in a prospective study. At the baseline visit, data on demographics, clinical variables, degree of asthma control according to the Asthma Control Test (ACT), basic spirometry and the Hospital Anxiety and Depression Scale (HADS) were collected and an ad hoc questionnaire was completed that allowed the degree of concordance between doctors and patients to be assessed...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29018447/trim25-in-the-regulation-of-the-antiviral-innate-immunity
#3
REVIEW
María Martín-Vicente, Luz M Medrano, Salvador Resino, Adolfo García-Sastre, Isidoro Martínez
TRIM25 is an E3 ubiquitin ligase enzyme that is involved in various cellular processes, including regulation of the innate immune response against viruses. TRIM25-mediated ubiquitination of the cytosolic pattern recognition receptor RIG-I is an essential step for initiation of the intracellular antiviral response and has been thoroughly documented. In recent years, however, additional roles of TRIM25 in early innate immunity are emerging, including negative regulation of RIG-I, activation of the melanoma differentiation-associated protein 5-mitochondrial antiviral signaling protein-TRAF6 antiviral axis and modulation of p53 levels and activity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29017832/impact-of-rhinitis-on-work-productivity-a-systematic-review
#4
Olivier Vandenplas, Denis Vinnikov, Paul D Blanc, Ioana Agache, Claus Bachert, Michael Bewick, Lars-Olaf Cardell, Paul Cullinan, Pascal Demoly, Alexis Descatha, Joao Fonseca, Tari Haahtela, Peter W Hellings, Jacques Jamart, Juha Jantunen, Ömer Kalayci, David Price, Boleslaw Samolinski, Joaquin Sastre, Longxiu Tian, Antonio L Valero, Xinyi Zhang, Jean Bousquet
BACKGROUND: Allergic rhinitis (AR) is increasingly acknowledged as having a substantial socioeconomic impact associated with impaired work productivity, although available information remains fragmented. OBJECTIVE: This systematic review summarizes recently available information to provide a quantitative estimate of the burden of AR on work productivity including lost work time (ie, absenteeism) and reduced performance while working (ie, presenteeism). METHODS: A Medline search retrieved original studies from 2005 to 2015 pertaining to the impact of AR on work productivity...
October 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28987991/bioaccumulation-maternal-transfer-and-effects-of-dietary-2-2-4-4-tetrabromodiphenyl-ether-bde-47-exposure-on-medaka-fish-oryzias-latipes-offspring
#5
Miguel González-Doncel, Salvador Sastre, Gregoria Carbonell, Eulalia María Beltrán, Cristina González Anaya, José Enrique García-Mauriño, Carlos Fernández Torija
A previous study conducted in our laboratory with growing medaka (Oryzias latipes) showed the capacity of BDE-47 (10-1000ng/g) to bioaccumulate during a 40-day oral exposure. However, the results did not provide evidence for effects during or after the exposure period. In this study, breeding medakas were fed a diet for 40days that contained 1000ng of BDE-47/g. At predefined time points, females (time points 10, 20, 30 and 40), males (time points 30 and 40) and pools of laid eggs (time points 10, 20, 30 and 40) were sampled and collected for: 1) the BDE-47 quantitative analysis in adults in the <24-h-old post-fertilization (hpf) embryos, and in the <24-h-old post-hatch (hph) eleutheroembryos; 2) the evaluation of fecundity, fertility and hatching...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28984163/epidemiology-of-nmosd-in-catalonia-influence-of-the-new-2015-criteria-in-incidence-and-prevalence-estimates
#6
Maria Sepúlveda, Marta Aldea, Domingo Escudero, Sara Llufriu, Georgina Arrambide, Susana Otero-Romero, J Sastre-Garriga, Lucía Romero-Pinel, Sergio Martínez-Yélamos, N Sola-Valls, Thais Armangué, Javier Sotoca, Antonio Escartín, René Robles-Cedeño, Lluís Ramió-Torrentà, Silvia Presas-Rodríguez, Cristina Ramo-Tello, Elvira Munteis, Raúl Pelayo, Laura Gubieras, Luis Brieva, Nicolau Ortiz, Mariona Hervás, Maria Alba Mañé-Martínez, Antonio Cano, Emili Vela, Mar Tintoré, Yolanda Blanco, Xavier Montalban, Francesc Graus, Albert Saiz
BACKGROUND: Population-based studies on neuromyelitis optica spectrum disorders (NMOSD) are limited, and it is unclear whether the rates have changed with the implementation of the new 2015 criteria. OBJECTIVES: To estimate the incidence and prevalence of NMOSD in Catalonia (Spain), using both the 2006 and the 2015 criteria. METHODS: In this clinic-based retrospective study, patients diagnosed with NMOSD between 2006 and 2015 were identified using multiple sources, including direct contact to all Catalan hospitals, identification of cases through the Catalan Health Surveillance System, and registry of antibodies to aquaporin-4 (AQP4-IgG) and myelin oligodendrocyte glycoprotein (MOG-IgG) in a reference laboratory...
October 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28979597/controversies-in-the-surgical-management-of-shoulder-instability-open-vs-arthroscopic-procedures
#7
Alejandro Huerta, Gustavo Rincón, Lluis Peidro, Andreu Combalia, Sergi Sastre
BACKGROUND: Traumatic anterior instability of the shoulder is a common condition associated with a high recurrence rate in young adults. Operative treatment reduces the risk of recurrence. Several studies have compared arthroscopic and open shoulder instability repair. The purpose of this paper is to perform a review of the literature where both techniques are compared in the repair of the anterior shoulder instability without bone loss. METHODS: Prior to arthroscopy, recurrent dislocations were managed by open repair...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28973441/pol%C3%AE-tumor-variants-decrease-the-efficiency-and-accuracy-of-nhej
#8
Guillermo Sastre-Moreno, John M Pryor, Alberto Díaz-Talavera, José F Ruiz, Dale A Ramsden, Luis Blanco
The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment of the broken ends, a complex task performed in human cells by two specialized DNA polymerases, Polλ and Polμ. It is now well established that Polμ is the one adapted to repair DSBs with non-complementary ends, the most challenging scenario, although the structural basis and physiological implications of this adaptation are not fully understood. Here, we demonstrate that two human Polμ point mutations, G174S and R175H, previously identified in two different tumor samples and affecting two adjacent residues, limit the efficiency of accurate NHEJ by Polμ in vitro and in vivo...
September 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28962985/domoic-acid-in-a-marine-pelagic-food-web-exposure-of-southern-right-whales-eubalaena-australis-to-domoic-acid-on-the-pen%C3%A3-nsula-vald%C3%A3-s-calving-ground-argentina
#9
Valeria C D'Agostino, Mariana Degrati, Viviana Sastre, Norma Santinelli, Bernd Krock, Torben Krohn, Silvana L Dans, Mónica S Hoffmeyer
The gulfs that surround Península Valdés (PV), Golfo Nuevo and Golfo San José in Argentina, are important calving grounds for the southern right whale Eubalaena australis. However, high calf mortality events in recent years could be associated with phycotoxin exposure. The present study evaluated the transfer of domoic acid (DA) from Pseudo-nitzschia spp., potential producers of DA, to living and dead right whales via zooplanktonic vectors, while the whales are on their calving ground at PV. Phytoplankton and mesozooplankton (primary prey of the right whales at PV and potential grazers of Pseudo-nitzschia cells) were collected during the 2015 whale season and analyzed for species composition and abundance...
September 2017: Harmful Algae
https://www.readbyqxmd.com/read/28960366/portal-pressure-and-liver-stiffness-measurements-in-the-prediction-of-fibrosis-regression-after-svr-in-recurrent-hepatitis-c
#10
Ezequiel Mauro, Gonzalo Crespo, Carla Montironi, Maria-Carlota Londoño, Virginia Hernández-Gea, Pablo Ruiz, Lydia Sastre, Julissa Lombardo, Zoe Mariño, Alba Díaz, Jordi Colmenero, Antoni Rimola, Juan Carlos Garcia-Pagan, Mercé Brunet, Xavier Forns, Miquel Navasa
Sustained virological response (SVR) improves survival in post liver transplant (LT) recurrent hepatitis C. However, the impact of SVR on fibrosis regression is not well defined. In addition, the performance of noninvasive methods to evaluate the presence of fibrosis and portal hypertension after SVR has been scarcely evaluated. We aimed to investigate the degree of fibrosis regression (decrease ≥1 METAVIR stage) after SVR and its associated factors in recurrent hepatitis C, as well as the diagnostic capacity of noninvasive methods in the assessment of liver fibrosis and portal hypertension after viral clearance...
September 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28953980/influenza-virus-differentially-activates-mtorc1-and-mtorc2-signaling-to-maximize-late-stage-replication
#11
Sharon K Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A Mata, Raquel Muñoz-Moreno, Xiang Chen, Florian Krammer, Michael S Diamond, Zhijian J Chen, Adolfo García-Sastre, Beatriz M A Fontoura
Influenza A virus usurps host signaling factors to regulate its replication. One example is mTOR, a cellular regulator of protein synthesis, growth and motility. While the role of mTORC1 in viral infection has been studied, the mechanisms that induce mTORC1 activation and the substrates regulated by mTORC1 during influenza virus infection have not been established. In addition, the role of mTORC2 during influenza virus infection remains unknown. Here we show that mTORC2 and PDPK1 differentially phosphorylate AKT upon influenza virus infection...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28946482/fuzzy-logic-modeling-of-pb-ii-sorption-onto-mesoporous-nio-zncl2-rosa-canina-l-seeds-activated-carbon-nanocomposite-prepared-by-ultrasound-assisted-co-precipitation-technique
#12
Hamedreza Javadian, Maryam Ghasemi, Montserrat Ruiz, Ana Maria Sastre, Seyed Mostafa Hosseini Asl, Mojtaba Masomi
In this study, NiO/Rosa Canina-L seeds activated carbon nanocomposite (NiO/ACNC) was prepared by adding dropwise NaOH solution (2mol/L) to raise the suspension pH to around 9 at room temperature under ultrasonic irradiation (200W) as an efficient method and characterized by FE-SEM, FTIR and N2 adsorption-desorption isotherm. The effect of different parameters such as contact time (0-120min), initial metal ion concentration (25-200mg/L), temperature (298, 318 and 333K), amount of adsorbent (0.002-0.007g) and the solution's initial pH (1-7) on the adsorption of Pb (II) was investigated in batch-scale experiments...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28905402/affinity-capillary-electrophoresis-for-the-assessment-of-binding-affinity-of-carbohydrate-based-cholera-toxin-inhibitors
#13
Oier Aizpurua-Olaizola, Javier Sastre Torano, Aliaksei Pukin, Ou Fu, Geert Jan Boons, Gerhardus J de Jong, Roland J Pieters
Developing tools for the study of protein carbohydrate interactions is an important goal in glycobiology. Cholera toxin inhibition is an interesting target in this context, as its inhibition may help the fight against cholera. For the study of novel ligands an affinity capillary electrophoresis (ACE) method was optimised and applied. The method uses unlabeled cholera toxin B-subunit (CTB) and unlabeled carbohydrate ligands based on ganglioside GM1-oligosaccharides (GM1os). In an optimized method at pH 4, adsorption of the protein to the capillary walls was prevented by a polybrene-dextran sulfate-polybrene (PB-DS-PB) coating...
September 14, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28901243/an-exploration-into-municipal-waste-charges-for-environmental-management-at-local-level-the-case-of-spain
#14
Ignasi Puig-Ventosa, Sergio Sastre Sanz
Municipal waste charges have been widely acknowledged as a crucial tool for waste management at the local level. This is because they contribute to financing the costly provision of waste collection and treatment services and they can be designed to provide an economic stimulus to encourage citizens and local businesses to improve separate collection and recycling. This work presents a methodology to evaluate a sample of 125 municipal waste charges in Spain for the year 2015, covering 33.91% of the Spanish population...
September 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28899746/performance-of-five-research-domain-automated-wm-lesion-segmentation-methods-in-a-multi-center-ms-study
#15
Alexandra de Sitter, Martijn D Steenwijk, Aurélie Ruet, Adriaan Versteeg, Yaou Liu, Ronald A van Schijndel, Petra J W Pouwels, Iris D Kilsdonk, Keith S Cover, Bob W van Dijk, Stefan Ropele, Maria A Rocca, Marios Yiannakas, Mike P Wattjes, Soheil Damangir, Giovanni B Frisoni, Jaume Sastre-Garriga, Alex Rovira, Christian Enzinger, Massimo Filippi, Jette Frederiksen, Olga Ciccarelli, Ludwig Kappos, Frederik Barkhof, Hugo Vrenken
BACKGROUND AND PURPOSE: In vivoidentification of white matter lesions plays a key-role in evaluation of patients with multiple sclerosis (MS). Automated lesion segmentation methods have been developed to substitute manual outlining, but evidence of their performance in multi-center investigations is lacking. In this work, five research-domain automated segmentation methods were evaluated using a multi-center MS dataset. METHODS: 70 MS patients (median EDSS of 2...
September 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28887880/allergy-rhinitis-similarities-and-differences-between-children-and-adults
#16
A Izquierdo-Dominguez, I Jauregui, A Del Cuvillo, J Montoro, I Davila, J Sastre, J Bartra, M Ferrer, I Alobid, J Mullol, A L Valero
BACKGROUND: Allergic rhinitis (AR) is a highly prevalent disease worldwide. Although a number of studies have described AR, no studies compared children and adult AR populations. The objective was to compare the AR characteristics between two AR cohorts of children and adults. METHODS: Two AR cohorts (children and adults) from Spain were studied through observational cross-sectional multicentre studies. AR was classified based on classical (allergen exposure), original (o-ARIA), and modified (m-ARIA) ARIA criteria...
September 9, 2017: Rhinology
https://www.readbyqxmd.com/read/28886928/geographic-atrophy-etiopathogenesis-and-current-therapies
#17
M Sastre-Ibáñez, A Barreiro-González, R Gallego-Pinazo, R Dolz-Marco, B García-Armendariz
Geographic atrophy is characterized by severe visual deficit whose etiology and pathophysiology are yet to be elucidated. As a working hypothesis, oxidative damage could trigger a chronic inflammation in Bruch's membrane-RPE-choriocapillaris complex, mostly due to complement pathway overactivation. Some individuals with mutations in the complement system and other factors have diminished capacity in the modulation of the inflammatory response, which results in cell damage and waste accumulation. This accumulation of intracellular and extracellular waste products manifests as drusen and pigmentary changes that precede the atrophy of photoreceptors, RPE, choriocapillaris with an ischemic process with decreased choroid flow...
September 5, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28869005/human-interactome-of-the-influenza-b-virus-ns1-protein
#18
Corinna Patzina, Catherine H Botting, Adolfo García-Sastre, Richard E Randall, Benjamin G Hale
NS1 proteins of influenza A and B viruses share limited sequence homology, yet both are potent manipulators of host cell processes, particularly interferon (IFN) induction. Although many cellular partners are reported for A/NS1, only a few (e.g. PKR and ISG15) have been identified for B/NS1. Here, affinity-purification and mass spectrometry were used to expand the known host interactome of B/NS1. We identified 22 human proteins as new putative targets for B/NS1, validating several, including DHX9, ILF3, YBX1 and HNRNPC...
September 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28868956/intracytoplasmic-filamentous-inclusions-and-ighv-rearrangements-in-a-patient-with-chronic-lymphocytic-leukemia
#19
Cecilia M Rodríguez, Carmen Stanganelli, Claudio Bussi, Daniela Arroyo, Darío Sastre, Viviana Heller, Pablo Iribarren, Irma Slavutsky
No abstract text is available yet for this article.
September 3, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28862734/utility-of-bruch-membrane-opening-based-optic-nerve-head-parameters-in-myopic-subjects
#20
Marina Sastre-Ibañez, Jose M Martinez-de-la-Casa, Gema Rebolleda, Pilar Cifuentes-Canorea, Maria Nieves-Moreno, Laura Morales-Fernandez, Federico Saenz-Frances, Julian Garcia-Feijoo
PURPOSE: To evaluate whether the new rim analysis software with spectral-domain optical coherence tomography (SD-OCT) shows advantages over the retinal nerve fiber layer (RNFL) thickness in patients with moderate myopia. METHODS: In this prospective cross-sectional study, we studied 65 healthy subjects, 37 with spherical refractive errors in the range of -3 to -6 D (moderate, G1) and 28 with less than -3 D (low/non-myopic, G0). All patients were examined with Heidelberg Spectralis SD-OCT, including Glaucoma Premium Module Edition (GPME) software...
August 11, 2017: European Journal of Ophthalmology
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