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https://www.readbyqxmd.com/read/28812045/soluble-st2-predicts-outcome-and-hemorrhagic-transformation-after-acute-stroke
#1
Zoe Wolcott, Ayush Batra, Matthew B Bevers, Cristina Sastre, Jane Khoury, Matthew Sperling, Brett C Meyer, Kyle B Walsh, Opeolu Adeoye, Joseph P Broderick, W Taylor Kimberly
OBJECTIVE: ST2 is a member of the toll-like receptor superfamily that can alter inflammatory signaling of helper T-cells. We investigated whether soluble ST2 (sST2) could independently predict outcome and hemorrhagic transformation (HT) in the setting of stroke. METHODS: We measured sST2 in patients enrolled in the Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) network biomarker study. 646 patients had plasma samples collected at the time of hospital admission and 210 patients had a second sample collected 48 h after stroke onset...
August 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28799903/ten-strategies-of-interferon-evasion-by-viruses
#2
REVIEW
Adolfo García-Sastre
Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral response to replicate and propagate to new hosts. The complex regulation of the IFN response allows viruses to antagonize IFN at multiple levels. However, no single strategy appears to be the golden ticket, and viruses have adopted multiple means to dampen this host defense. This Review does not exhaustively cover all mechanisms of viral IFN antagonism. Rather it examines the ten most common strategies that viruses use to subvert the IFN response with examples from publications appearing in the last 10 years of Cell Host & Microbe...
August 9, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28783704/constitutive-resistance-to-viral-infection-in-human-cd141-dendritic-cells
#3
Aymeric Silvin, Chun I Yu, Xavier Lahaye, Francesco Imperatore, Jean-Baptiste Brault, Sylvain Cardinaud, Christian Becker, Wing-Hong Kwan, Cécile Conrad, Mathieu Maurin, Christel Goudot, Santy Marques-Ladeira, Yuanyuan Wang, Virginia Pascual, Esperanza Anguiano, Randy A Albrecht, Matteo Iannacone, Adolfo García-Sastre, Bruno Goud, Marc Dalod, Arnaud Moris, Miriam Merad, A Karolina Palucka, Nicolas Manel
Dendritic cells (DCs) are critical for the launching of protective T cell immunity in response to viral infection. Viruses can directly infect DCs, thereby compromising their viability and suppressing their ability to activate immune responses. How DC function is maintained in light of this paradox is not understood. By analyzing the susceptibility of primary human DC subsets to viral infections, we report that CD141(+) DCs have an innate resistance to infection by a broad range of enveloped viruses, including HIV and influenza virus...
July 7, 2017: Science Immunology
https://www.readbyqxmd.com/read/28780125/effects-of-fullerene-on-lipid-bilayers-displaying-different-liquid-ordering-a-coarse-grained-molecular-dynamics-study
#4
Judit Sastre, Ilaria Mannelli, Ramon Reigada
BACKGROUND: The toxic effects and environmental impact of nanomaterials, and in particular of Fullerene particles, are matters of serious concern. It has been reported that fullerene molecules enter the cell membrane and occupy its hydrophobic region. Understanding the effects of carbon-based nanoparticles on biological membranes is therefore of critical importance to determine their exposure risks. METHODS: We report on a systematic coarse-grained molecular dynamics study of the interaction of fullerene molecules with simple model cell membranes...
August 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28758655/inhibitors-of-nicotinamide-n-methyltransferase-designed-to-mimic-the-methylation-reaction-transition-state
#5
Matthijs J van Haren, Rebecca Taig, Jilles Kuppens, Javier Sastre Toraño, Ed E Moret, Richard B Parsons, Davide Sartini, Monica Emanuelli, Nathaniel I Martin
Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyses the methylation of nicotinamide to form N'-methylnicotinamide. Both NNMT and its methylated product have recently been linked to a variety of diseases, suggesting a role for the enzyme as a therapeutic target beyond its previously ascribed metabolic function in detoxification. We here describe the systematic development of NNMT inhibitors derived from the structures of the substrates involved in the methylation reaction. By covalently linking fragments of the NNMT substrates a diverse library of bisubstrate-like compounds was prepared...
August 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28748977/solvent-dependent-photo-induced-dynamics-in-a-non-rigidly-linked-zinc-phthalocyanine-perylenediimide-dyad-probed-using-ultrafast-spectroscopy
#6
Bryan Kudisch, Margherita Maiuri, Vicente M Blas-Ferrando, Javier Ortiz, Ángela Sastre-Santos, Gregory D Scholes
In this work, we characterize the energy and electron transfer kinetics of a zinc phthalocyanine-perylenediimide dyad (ZnPc-PDI) in various solvents using steady-state and tunable narrowband pump-probe spectroscopy. We fit the ultrafast data with global analysis techniques and find that upon excitation of the PDI moiety (pump pulse at 540 nm), the excitation energy transfer (EET) rate to the ZnPc moiety displays a solvent sensitivity that we attribute to changes in the relative equilibrium moiety orientation...
August 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28739251/evidence-for-an-important-role-of-host-micrornas-in-regulating-hepatic-fibrosis-in-humans-infected-with-schistosoma-japonicum
#7
Sandrine Cabantous, Xunya Hou, Laurence Louis, Hongbin He, Odette Mariani, Xavier Sastre, Martine Daujat-Chavanieu, Yuesheng Li, Alain Dessein
MicroRNAs (miRNAs) are short, non-coding RNAs that repress the translation of target gene transcripts. They have been implicated in various activities such as cell proliferation, survival, differentiation, migration and metabolism. We report here the first known miRNome and transcriptome analysis of human livers displaying advanced fibrosis due to Schistosoma japonicum infection. We present evidence that hsa-miR-150-5p, hsa-miR-10a-5p, hsa-miR-199a-3p, hsa-miR-4521, hsa-miR-222/221, hsa-miR-663b and hsa-miR-143-3p (associated without correction) play an important role in hepatic fibrosis by acting on metabolism, organization of the extracellular matrix proteins, lipid mobilization and limitation of oxidative damage stress...
July 21, 2017: International Journal for Parasitology
https://www.readbyqxmd.com/read/28732985/numerical-models-for-the-study-of-the-nonlinear-frequency-mixing-in-two-and-three-dimensional-resonant-cavities-filled-with-a-bubbly-liquid
#8
María Teresa Tejedor Sastre, Christian Vanhille
The objective of this work is to develop versatile numerical models to study the nonlinear distortion of ultrasounds and the generation of low-ultrasonic frequency signals by nonlinear frequency mixing in two and three-dimensional resonators filled with bubbly liquids. The interaction of the acoustic field and the bubble vibrations is modeled through a coupled differential system formed by the multi-dimensional wave equation and a Rayleigh-Plesset equation. The numerical models we develop are based on multi-dimensional finite-volume techniques and a time discretization carried out by finite differences...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28731620/solvent-free-off-on-detection-of-the-improvised-explosive-triacetone-triperoxide-tatp-with-fluorogenic-materials
#9
Tomas Torroba, Patricia Calvo-Gredilla, Jose Garcia-Calvo, Jose V Cuevas, Jesus-Luis Pablos, Felix C Garcia, Jose-Miguel Garcia, Nathalie Zink-Lorre, Enrique Font-Sanchis, Angela Sastre-Santos, Fernando Fernandez-Lazaro
We have developed a fluorogenic perylenediimide functionalized polyacrylate capable to generate color and fluorescence changes in the presence of triacetone triperoxide, TATP, an improvised explosive used in terrorist attacks, under solvent-free, solid state conditions. The material works by accumulating the volatile TATP until it reaches a threshold, therefore triggering colorimetric and fluorescent responses.
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28704962/sirt3-oncogene-and-tumor-suppressor-in-cancer
#10
REVIEW
Margalida Torrens-Mas, Jordi Oliver, Pilar Roca, Jorge Sastre-Serra
Sirtuin 3 (SIRT3), the major deacetylase in mitochondria, plays a crucial role in modulating oxygen reactive species (ROS) and limiting the oxidative damage in cellular components. SIRT3 targets different enzymes which regulate mitochondrial metabolism and participate in ROS detoxification, such as the complexes of the respiratory chain, the isocitrate dehydrogenase, or the manganese superoxide dismutase. Thus, SIRT3 activity is essential in maintaining mitochondria homeostasis and has recently received great attention, as it is considered a fidelity protein for mitochondrial function...
July 12, 2017: Cancers
https://www.readbyqxmd.com/read/28701948/microglial-activation-in-traumatic-brain-injury
#11
REVIEW
Cornelius K Donat, Gregory Scott, Steve M Gentleman, Magdalena Sastre
Microglia have a variety of functions in the brain, including synaptic pruning, CNS repair and mediating the immune response against peripheral infection. Microglia rapidly become activated in response to CNS damage. Depending on the nature of the stimulus, microglia can take a number of activation states, which correspond to altered microglia morphology, gene expression and function. It has been reported that early microglia activation following traumatic brain injury (TBI) may contribute to the restoration of homeostasis in the brain...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28694725/impact-of-reference-change-value-rcv-based-autoverification-on-turnaround-time-and-physician-satisfaction
#12
Esther Fernández-Grande, Carolina Valera-Rodriguez, Luis Sáenz-Mateos, Amparo Sastre-Gómez, Pilar García-Chico, Teodoro J Palomino-Muñoz
BACKGROUND: For a quicker delivery of laboratory test results to the hospital emergency department (ED), we implemented an autoverification system based on the reference change value (RCV). The aim of this study was to assess how the RCV based autoverification reflected on turnaround time (TAT) and on physician satisfaction. MATERIALS AND METHODS: The laboratory information system (LIS) was programmed to autoverify the results as long as they were within the range settled by RCV, so that the autoverified results were reported to the physician as soon as the tests were carried out, without any further intervention...
June 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/28694008/-reduced-intensity-conditioning-haematopoietic-stem-cell-transplantation-in-genetic-diseases-experience-of-the-spanish-working-group-for-bone-marrow-transplantation-in-children
#13
Lucía López-Granados, Montserrat Torrent, Ana Sastre, Marta Gonzalez-Vicent, Cristina Díaz de Heredia, Bienvenida Argilés, Antonia Pascual, José M Pérez-Hurtado, Luisa Sisinni, Miguel Ángel Diaz, Izaskun Elorza, M Angeles Dasí, Isabel Badell
INTRODUCTION: Haematopoietic stem cell transplantation (HSCT) involves implanting cellular elements capable of generating a new and healthy haematopoietic system. Reduced intensity conditioning (RIC) consists of an immunosuppressive treatment to facilitate a progressive implant with lower morbidity. This type of conditioning can also lead to myelosuppression, which is potentially reversible over time. Reduced intensity conditioning enables HSCT to be performed on patients with genetic diseases for whom added comorbidity is undesirable due to the high doses of chemotherapy that accompanies conventional myeloablative regimens...
July 7, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28689450/recent-advances-and-clinical-insights-into-the-use-of-proteomics-in-the-study-of-atherosclerosis
#14
Laura Mourino-Alvarez, Montserrat Baldan-Martin, Raul Rincon, Tatiana Martin-Rojas, Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Maria G Barderas
The application of new proteomics methods may help to identify new diagnostic/predictive molecular markers in an attempt to improve the clinical management of atherosclerosis. Areas covered: Technological advances in proteomics have enhanced its sensitivity and multiplexing capacity, as well as the possibility of studying protein interactions and tissue structure. These advances will help us better understand the molecular mechanisms at play in atherosclerosis as a biological system. Moreover, this should help identify new predictive/diagnostic biomarkers and therapeutic targets that may facilitate effective risk stratification and early diagnosis, with the ensuing rapid implementation of treatment...
July 14, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28685869/biomarkers-of-the-alcohol-hangover-state-ethyl-glucuronide-etg-and-ethyl-sulfate-ets
#15
Marlou Mackus, Aurora J A E van de Loo, S Jorinde Raasveld, Anna Hogewoning, Javier Sastre Toraño, Frits M Flesch, Gerdien A H Korte-Bouws, Renier H P van Neer, Xiaochun Wang, Thomas T Nguyen, Karel A Brookhuis, Aletta D Kraneveld, Johan Garssen, Joris C Verster
INTRODUCTION: The aim of this study was to investigate the usefulness of ethyl glucuronide (EtG) and ethyl sulfate (EtS) as biomarkers of the hangover state. METHODS: Thirty-sixhealthy social drinkers participated in this study, being of naturalistic design. Eighteen participants experience regular hangovers (the hangover group), whereas the other 18 claim to not experience a hangover (the hangover-immune group). On a control day (alcohol-free) day and a post-alcohol day, urine EtG and EtS concentrations were determined and hangover severity assessed...
July 6, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28678834/normative-database-for-separate-inner-retinal-layers-thickness-using-spectral-domain-optical-coherence-tomography-in-caucasian-population
#16
María Nieves-Moreno, Jose M Martínez-de-la-Casa, Pilar Cifuentes-Canorea, Marina Sastre-Ibáñez, Enrique Santos-Bueso, Federico Sáenz-Francés, Laura Morales-Fernández, Julián García-Feijoó
PURPOSE: Develop the first normative database of the thickness of every inner retinal layer in the macular area in a healthy, Caucasian population between 18 to 87 years old, using Spectralis Optical Coherence Tomography (OCT). METHODS: On this transversal, observational study, 300 patients between 18 to 87 years old and without an ophthalmological condition were recruited. Macular OCT scans were performed on all patients (Spectralis OCT, Heidelberg Engineering)...
2017: PloS One
https://www.readbyqxmd.com/read/28676340/molecular-and-morphological-characterization-of-acanthamoeba-isolated-from-corneal-scrapes-and-contact-lens-wearers-in-argentina
#17
Rodolfo D Casero, Florencia Mongi, Laura Laconte, Fernando Rivero, Dario Sastre, Aníbal Teherán, Giovanny Herrera, Juan David Ramírez
In this study, we describe the frequency of Acanthamoeba keratitis (AK) in patients that assisted in the Ophthalmology Department and determine the species/genotypes of free living amoebas (FLA) isolates. FLA from Corneal scrapes (CS) and contact lens (CL) wearers were studied by morphological and molecular characterization. A database was constructed with sociodemographic, clinical findings and history of use of CL variables. During January 2000 and September 2016 patients with corneal pathology admitted to the Ophthalmology Service of the University Hospital in Córdoba city, Argentina were included in the study...
July 1, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28663209/is-it-possible-to-develop-a-universal-influenza-virus-vaccine-toward-a-universal-influenza-virus-vaccine-potential-target-antigens-and-critical-aspects-for-vaccine-development
#18
Florian Krammer, Adolfo García-Sastre, Peter Palese
Influenza viruses cause seasonal epidemics as well as pandemics and are a significant concern for human health. Current influenza virus vaccines show efficacy when they are antigenically well matched to circulating strains. Seasonal influenza viruses undergo antigenic drift at a high rate and, therefore, current vaccines have to be reformulated and readministered on an annual basis. Mismatches between vaccine strains and circulating strains frequently occur, significantly decreasing vaccine efficacy. In addition, current seasonal influenza virus vaccines have limited efficacy against newly emerging pandemic viruses...
June 29, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28649744/mannose-binding-lectin-deficient-donors-increase-the-risk-of-bacterial-infection-and-bacterial-infection-related-mortality-after-liver-transplantation
#19
J Lombardo-Quezada, G Sanclemente, J Colmenero, M Español-Rego, M T Arias, P Ruiz, E Mauro, L Sastre, G Crespo, A Rimola, A Moreno, F Lozano, M Navasa
Mannose-binding lectin (MBL) is synthesized by the liver and binds to microbes. MBL2 gene polymorphisms produce intermediate/low/null or normal MBL serum levels (MBL-deficient or MBL-sufficient phenotypes, respectively). We aimed to evaluate the incidence and severity of infection, rejection, and survival within 1 year after liver transplantation (LT) according to donor and recipient MBL2 gene polymorphisms. A repeated-event analysis for infection episodes (negative binomial regression, Andersen-Gill model) was performed in 240 LTs...
June 26, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28641544/post-mortem-redistribution-of-drugs-current-state-of-knowledge
#20
Caroline Sastre, Christophe Bartoli, Valerie Baillif-Couniou, Georges Leonetti, Anne-Laure Pelissier-Alicot
BACKGROUND: Drug concentrations obtained from post mortem samples do not necessarily reflect the concentrations at the time of death, and variations of concentration may be observed between different sites and/or different sampling times. These phenomena, collectively termed post mortem redistribution, concern numerous molecules (medications, drugs of abuse, gases, etc.) and can complicate the interpretation of toxicological analyses. METHODS: Literature review...
June 22, 2017: Current Pharmaceutical Design
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