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https://www.readbyqxmd.com/read/29667096/evaluation-of-the-novel-non-invasive-zero-heat-flux-tcore%C3%A2-thermometer-in-cardiac-surgical-patients
#1
José A Sastre, María J Pascual, Teresa López
Tcore™ Sensor is a novel zero-heat-flux thermometer that estimates core temperature from skin over forehead. We tested the hypothesis that this system estimates core temperature to an accuracy within 0.5 °C. 40 cardiac surgical patients were enrolled (960 measurements). Reference core temperatures were measured in nasopharynx, pulmonary artery and the arterial branch of the oxygenator of the cardiopulmonary bypass (CPB) circuit. 95% Bland-Altman limits of agreement for repeated measurement data was used to study the agreement between Tcore™ thermometer and the reference methods...
April 17, 2018: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29661169/rna-seq-reveals-the-existence-of-a-cdkn1c-e2f1-tp53-axis-that-is-altered-in-human-t-cell-lymphoblastic-lymphomas
#2
Pilar López-Nieva, Pablo Fernández-Navarro, Concepción Vaquero-Lorenzo, María Villa-Morales, Osvaldo Graña-Castro, María Ángeles Cobos-Fernández, José Luis López-Lorenzo, Pilar Llamas, Laura González-Sanchez, Isabel Sastre, Marina Pollan, Marcos Malumbres, Javier Santos, José Fernández-Piqueras
BACKGROUND: Precursor T-cell lymphoblastic lymphomas (T-LBL) are rare aggressive hematological malignancies that mainly develop in children. As in other cancers, the loss of cell cycle control plays a prominent role in the pathogenesis in these malignancies that is primarily attributed to loss of CDKN2A (encoding protein p16INK4A). However, the impact of the deregulation of other genes such as CDKN1C, E2F1, and TP53 remains to be clarified. Interestingly, experiments in mouse models have proven that conditional T-cell specific deletion of Cdkn1c gene may induce a differentiation block at the DN3 to DN4 transition, and that the loss of this gene in the absence of Tp53 led to aggressive thymic lymphomas...
April 16, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29628214/-neuroleptic-malignant-syndrome-after-withdrawal-of-levopoda
#3
Bernardo Cedeno-Veloz, Almudena Areosa Sastre
No abstract text is available yet for this article.
April 5, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29624387/computer-aided-discovery-and-characterization-of-novel-ebola-virus-inhibitors
#4
Stephen Joseph Capuzzi, Wei Sun, Eugene N Muratov, Carles Martinez-Romero, Shihua He, Wenjun Zhu, Hao Li, Gregory James Tawa, Ethan G Fisher, Miao Xu, Paul Shinn, Xiangguo Qiu, Adolfo García-Sastre, Wei Zheng, Alexander Tropsha
The Ebola virus (EBOV) causes severe human infection that lacks effective treatment. A recent screen identified a series of compounds that block EBOV-like particle entry into human cells. Using data from this screen, Quantitative Structure-Activity Relationship (QSAR) models were built and employed for virtual screening of a ~17 million compound library. Experimental testing of 102 hits yielded 14 compounds with IC50 values under 10 μM, including several sub-micromolar inhibitors, and more than 10-fold selectivity against host cytotoxicity...
April 6, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29609576/photovoice-and-empowerment-evaluating-the-transformative-potential-of-a-participatory-action-research-project
#5
Kirsten Budig, Julia Diez, Paloma Conde, Marta Sastre, Mariano Hernán, Manuel Franco
BACKGROUND: Photovoice is a visual research methodology with the intention to foster social change. Photovoice has been used to investigate change in empowerment in vulnerable communities, However, the individual experience of participants involved in Photovoice projects is seldom scrutinized. Our aim was to explore and describe the individual experiences of the female individuals who participated in a previous Photovoice project. We analyzed a change in the women's empowerment in terms of: 1) gain in knowledge and skills, 2) change in self-perception, and 3) access to and use of resources...
April 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29605235/application-of-a-short-term-air-quality-action-plan-in-madrid-spain-under-a-high-pollution-episode-part-i-diagnostic-and-analysis-from-observations
#6
Rafael Borge, Begoña Artíñano, Carlos Yagüe, Francisco Javier Gomez-Moreno, Alfonso Saiz-Lopez, Mariano Sastre, Adolfo Narros, David García-Nieto, Nuria Benavent, Gregorio Maqueda, Marcos Barreiro, Juan Manuel de Andrés, Ángeles Cristóbal
Exceedances of NO2 hourly limit value (200 μg·m-3 ) imply the need to implement short term action plans to avoid adverse effects on human health in urban areas. The Madrid City Council applied the stage 3 of the NO2 protocol during a high-pollution episode under stable meteorological conditions on December 2016 for the first time. This included road traffic access restrictions to the city centre (50% of conventional private vehicles based on plate numbers). In this contribution we analyse different meteorological and air quality observations, including non-standard parameters (such as number of ultrafine particles and remote sensing techniques MAXDOAS) for a better understanding of the effectivity of short-term emission abatement measures under real conditions and to identify options to improve the NO2 protocol in the future...
March 28, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29601514/diphenylphenoxy-thiophene-pdi-dimers-as-acceptors-for-opv-applications-with-open-circuit-voltage-approaching-1-volt
#7
Caterina Stenta, Desiré Molina, Aurélien Viterisi, María Pilar Montero-Rama, Sara Pla, Werther Cambarau, Fernando Fernández-Lázaro, Emilio Palomares, Lluis F Marsal, Ángela Sastre-Santos
Two new perylenediimides (PDIs) have been developed for use as electron acceptors in solution-processed bulk heterojunction solar cells. The compounds were designed to exhibit maximal solubility in organic solvents, and reduced aggregation in the solid state. In order to achieve this, diphenylphenoxy groups were used to functionalize a monomeric PDI core, and two PDI dimers were bridged with either one or two thiophene units. In photovoltaic devices prepared using PDI dimers and a monomer in conjunction with PTB7, it was found that the formation of crystalline domains in either the acceptor or donor was completely suppressed...
March 30, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29587145/spatial-temporal-lineage-restrictions-of-embryonic-p63-progenitors-establish-distinct-stem-cell-pools-in-adult-airways
#8
Ying Yang, Paul Riccio, Michael Schotsaert, Munemasa Mori, Jining Lu, Dong-Kee Lee, Adolfo García-Sastre, Jianming Xu, Wellington V Cardoso
Basal cells (BCs) are p63-expressing multipotent progenitors of skin, tracheoesophageal and urinary tracts. p63 is abundant in developing airways; however, it remains largely unclear how embryonic p63+ cells contribute to the developing and postnatal respiratory tract epithelium, and ultimately how they relate to adult BCs. Using lineage-tracing and functional approaches in vivo, we show that p63+ cells arising from the lung primordium are initially multipotent progenitors of airway and alveolar lineages but later become restricted proximally to generate the tracheal adult stem cell pool...
March 26, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29582852/the-current-role-of-mri-in-differentiating-multiple-sclerosis-from-its-imaging-mimics
#9
Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou
This corrects the article DOI: 10.1038/nrneurol.2018.14.
March 20, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29569486/pharmacoepigenetics-in-childhood-acute-lymphoblastic-leukemia-involvement-of-mirna-polymorphisms-in-hepatotoxicity
#10
Angela Gutierrez-Camino, Maitane Umerez, Borja Santos, Idoia Martin-Guerrero, Nagore García de Andoin, Ana Sastre, Aurora Navajas, Itziar Astigarraga, Africa Garcia-Orad
AIM: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function could be modulated by SNPs. As a consequence, we hypothesized that variants in miRNAs could be associated with drug-induced hepatotoxicity. METHODS: We analyzed 213 SNPs in 206 miRNAs in a cohort of 179 children with ALL homogeneously treated...
March 23, 2018: Epigenomics
https://www.readbyqxmd.com/read/29567616/age-dependent-regulation-of-antioxidant-genes-by-p38%C3%AE-mapk-in-the-liver
#11
Salvador Pérez, Sergio Rius-Pérez, Ana M Tormos, Isabela Finamor, Ángel R Nebreda, Raquel Taléns-Visconti, Juan Sastre
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related changes. For this purpose, we used liver-specific p38α-deficient mice at two different ages: young-mice (4 months-old) and old-mice (24 months-old). The liver of young p38α knock-out mice exhibited a decrease in GSH levels and an increase in GSSG/GSH ratio and malondialdehyde levels...
February 17, 2018: Redox Biology
https://www.readbyqxmd.com/read/29566971/the-mega-project-a-study-of-the-mechanisms-involved-in-the-genesis-and-disease-course-of-asthma-asthma-cohort-creation-and-long-term-follow-up
#12
Xavier Muñoz, María José Álvarez-Puebla, Ebymar Arismendi, Lourdes Arochena, María Del Pilar Ausín, Pilar Barranco, Irina Bobolea, Jose Antonio Cañas, Blanca Cardaba, Astrid Crespo, Victora Del Pozo, Javier Domínguez-Ortega, María Del Mar Fernandez-Nieto, Jordi Giner, Francisco Javier González-Barcala, Juan Alberto Luna, Joaquim Mullol, Iñigo Ojanguren, José María Olaguibel, César Picado, Vicente Plaza, Santiago Quirce, David Ramos, Manuel Rial, Christian Romero-Mesones, Francisco Javier Salgado, María Esther San-José, Silvia Sánchez-Diez, Beatriz Sastre, Joaquin Sastre, Lorena Soto, Montserrat Torrejón, Marisa Urnadoz, Luis Valdes, Antonio Valero, María Jesús Cruz
The general aim of this study is to create a cohort of asthma patients with varying grades of severity in order to gain greater insight into the mechanisms underlying the genesis and course of this disease. The specific objectives focus on various studies, including imaging, lung function, inflammation, and bronchial hyperresponsiveness, to determine the relevant events that characterize the asthma population, the long-term parameters that can determine changes in the severity of patients, and the treatments that influence disease progression...
March 19, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29562638/characterization-of-carotid-smooth-muscle-cells-during-phenotypic-transition
#13
Haize Goikuria, Maria Del Mar Freijo, Reyes Vega Manrique, María Sastre, Elena Elizagaray, Ana Lorenzo, Koen Vandenbroeck, Iraide Alloza
Vascular smooth muscle cells (VSMCs) are central players in carotid atherosclerosis plaque development. Although the precise mechanisms involved in plaque destabilization are not completely understood, it is known that VSMC proliferation and migration participate in plaque stabilization. In this study, we analyzed expression patterns of genes involved in carotid atherosclerosis development (e.g., transcription factors of regulation of SMC genes) of VSMCs located inside or outside the plaque lesion that may give clues about changes in phenotypic plasticity during atherosclerosis...
March 18, 2018: Cells
https://www.readbyqxmd.com/read/29560985/engineered-contrast-agents-in-a-single-structure-for-t-1-t-2-dual-magnetic-resonance-imaging
#14
Alejandro Cabrera-García, Elisa Checa-Chavarria, Jesús Pacheco-Torres, Ángela Bernabeu-Sanz, Alejandro Vidal-Moya, Eva Rivero-Buceta, Germán Sastre, Eduardo Fernández, Pablo Botella
The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T1-T2 dual-mode relaxivity requires the accurate assembly of T1 and T2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)4[Fe(CN)6] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH...
March 21, 2018: Nanoscale
https://www.readbyqxmd.com/read/29555916/potential-role-of-new-molecular-plasma-signatures-on-cardiovascular-risk-stratification-in-asymptomatic-individuals
#15
Montserrat Baldan-Martin, Juan A Lopez, Nerea Corbacho-Alonso, Paula J Martinez, Elena Rodriguez-Sanchez, Laura Mourino-Alvarez, Tamara Sastre-Oliva, Tatiana Martin-Rojas, Raul Rincón, Eva Calvo, Jesus Vazquez, Fernando Vivanco, Luis R Padial, Gloria Alvarez-Llamas, Gema Ruiz-Hurtado, Luis M Ruilope, Maria G Barderas
The evaluation of cardiovascular (CV) risk is based on equations derived from epidemiological data in individuals beyond the limits of middle age such as the Framingham and SCORE risk assessments. Lifetime Risk calculator (QRisk® ), estimates CV risk throughout a subjects' lifetime, allowing those. A more aggressive and earlier intervention to be identified and offered protection from the consequences of CV and renal disease. The search for molecular profiles in young people that allow a correct stratification of CV risk would be of great interest to adopt preventive therapeutic measures in individuals at high CV risk...
March 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29541394/selective-targeting-of-collagen-iv-in-the-cancer-cell-microenvironment-reduces-tumor-burden
#16
Fernando Revert, Francisco Revert-Ros, Raül Blasco, Aida Artigot, Ernesto López-Pascual, Roberto Gozalbo-Rovira, Ignacio Ventura, Elain Gutiérrez-Carbonell, Nuria Roda, Daniel Ruíz-Sanchis, Jerónimo Forteza, Javier Alcácer, Alejandra Pérez-Sastre, Ana Díaz, Enrique Pérez-Payá, Juan F Sanz-Cervera, Juan Saus
Goodpasture antigen-binding protein (GPBP) is an exportable1 Ser/Thr kinase that induces collagen IV expansion and has been associated with chemoresistance following epithelial-to-mesenchymal transition (EMT). Here we demonstrate that cancer EMT phenotypes secrete GPBP (mesenchymal GPBP) which displays a predominant multimeric oligomerization and directs the formation of previously unrecognized mesh collagen IV networks (mesenchymal collagen IV). Yeast two-hybrid (YTH) system was used to identify a260 SHCIE264 motif critical for multimeric GPBP assembly which then facilitated design of a series of potential peptidomimetics...
February 16, 2018: Oncotarget
https://www.readbyqxmd.com/read/29526739/insights-into-maleimide-thiol-conjugation-chemistry-conditions-for-efficient-surface-functionalization-of-nanoparticles-for-receptor-targeting
#17
Lucía Martínez-Jothar, Sofia Doulkeridou, Raymond M Schiffelers, Javier Sastre Torano, Sabrina Oliveira, Cornelus F van Nostrum, Wim E Hennink
Maleimide-thiol chemistry is widely used for the design and preparation of ligand-decorated drug delivery systems such as poly(lactide-co-glycolide) (PLGA) based nanoparticles (NPs). While many publications on nanocarriers functionalized exploiting this strategy are available in the literature, the conditions at which this reaction takes place vary among publications. This paper presents a comprehensive study on the conjugation of the peptide cRGDfK and the nanobody 11A4 (both containing a free thiol group) to maleimide functionalized PLGA NPs by means of the maleimide-thiol click reaction...
March 8, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29521337/the-current-role-of-mri-in-differentiating-multiple-sclerosis-from-its-imaging-mimics
#18
REVIEW
Ruth Geraldes, Olga Ciccarelli, Frederik Barkhof, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Monika Hofer, Friedemann Paul, Paolo Preziosa, Alex Rovira, Gabriele C DeLuca, Ludwig Kappos, Tarek Yousry, Franz Fazekas, Jette Frederiksen, Claudio Gasperini, Jaume Sastre-Garriga, Nikos Evangelou, Jacqueline Palace
MRI red flags proposed over a decade ago by the European Magnetic Resonance Network in MS (MAGNIMS) have guided clinicians in the diagnosis of multiple sclerosis (MS). However, the past 10 years have seen increased recognition that vascular disease can coexist and possibly interact with MS, improvements in the reliability of ways to differentiate MS from novel antibody-mediated CNS disorders (such as anti-aquaporin-4 antibody and myelin-oligodendrocyte glycoprotein antibody-associated diseases) and advances in MRI techniques...
March 9, 2018: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29517382/mapping-french-people-s-views-regarding-posthumous-reproduction
#19
Elodie Pajot, María Teresa Muñoz Sastre, Etienne Mullet
OBJECTIVE: The study mapped French people's views regarding the acceptability of posthumous reproduction. BACKGROUND: Posthumous reproduction - the use of a deceased person's gametes for procreative purposes -is a controversial procedure because it involves a series of ethical issues, namely the surviving partner's rights to procreation, the emotional feelings and financial interests of other family members, and the government's interest in maintaining orderly inheritance rules...
November 2017: Journal of Reproductive and Infant Psychology
https://www.readbyqxmd.com/read/29516453/-executive-neurofunctionality-a-comparative-study-in-high-intellectual-abilities
#20
S Sastre-Riba, T Ortiz
INTRODUCTION: From a differential perspective, high intellectual ability is an expression of intellectual functioning with characteristic functional correlates and structural correlates of the underlying neural activity that suggests an improved executive capacity as a relevant characteristic, highlighting in it a more effective working memory. DEVELOPMENT: The neuroscientific evidences about the neural mechanisms that can explain the differences are analyzed between the intellectual functioning of the high intellectual ability and the typical intellectual capacity...
March 1, 2018: Revista de Neurologia
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