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https://www.readbyqxmd.com/read/29211802/hidden-%C3%AE-helical-propensity-segments-within-disordered-regions-of-the-transcriptional-activator-chop
#1
Ángeles Canales, Marcel Rösinger, Javier Sastre, Isabella C Felli, Jesús Jiménez-Barbero, Guillermo Giménez-Gallego, Carlos Fernández-Tornero
C/EBP-homologous protein (CHOP) is a key determinant of the apoptotic response to endoplasmic reticulum stress or DNA damage. As a member of the C/EBP family, CHOP contains a low complexity N-terminal region involved in transcriptional activation, followed by a bZIP that binds DNA after dimerization. However, in contrast to other C/EBPs, CHOP directs binding to non-canonical C/EBP sites due to unique substitutions in its DNA-binding domain. Herein, we show that the N-terminal region of CHOP is intrinsically unstructured but contains two segments presenting α-helical propensity...
2017: PloS One
https://www.readbyqxmd.com/read/29203926/pandemic-h1n1-influenza-a-viruses-suppress-immunogenic-ripk3-driven-dendritic-cell-death
#2
Boris M Hartmann, Randy A Albrecht, Elena Zaslavsky, German Nudelman, Hanna Pincas, Nada Marjanovic, Michael Schotsaert, Carles Martínez-Romero, Rafael Fenutria, Justin P Ingram, Irene Ramos, Ana Fernandez-Sesma, Siddharth Balachandran, Adolfo García-Sastre, Stuart C Sealfon
The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating 1918 strain motivates finding strain-specific host-pathogen mechanisms. During infection, dendritic cells (DC) mature into antigen-presenting cells that activate T cells, linking innate to adaptive immunity. DC infection with seasonal IAVs, but not with the 1918 and 2009 pandemic strains, induces global RNA degradation. Here, we show that DC infection with seasonal IAV causes immunogenic RIPK3-mediated cell death. Pandemic IAV suppresses this immunogenic DC cell death...
December 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/29195658/a-typical-case-of-lipoblastoma-on-the-lower-limb-of-an-infant
#3
L Giraldo Mordecay, M P Novoa Candia, C E Torres Fuentes, A M Sastre Zuluaga
No abstract text is available yet for this article.
November 28, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29190561/labile-and-stable-soil-organic-carbon-and-physical-improvements-using-groundcovers-in-vineyards-from-central-spain
#4
Andrés García-Díaz, María José Marqués, Blanca Sastre, Ramón Bienes
Mediterranean vineyards are usually managed with continuous tillage to maintain bare soils leading to low organic matter stocks and soil degradation. Vineyards are part of the Mediterranean culture, their management can be sustainable. We propose the setup of two types of groundcovers with the aim to assess their potential influence to improve soil properties. A field trial was performed to compare the effects of a seeded (Brachypodium distachyon) and spontaneous groundcovers, on a set of soil parameters, in comparison with the traditional tillage in four vineyards located in the center of Spain...
November 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29190509/genetic-determinants-of-freckle-occurrence-in-the-spanish-population-towards-ephelides-prediction-from-human-dna-samples
#5
Barbara Hernando, Maria Victoria Ibañez, Julio Alberto Deserio-Cuesta, Raquel Soria-Navarro, Inca Vilar-Sastre, Conrado Martinez-Cadenas
Prediction of human pigmentation traits, one of the most differentiable externally visible characteristics among individuals, from biological samples represents a useful tool in the field of forensic DNA phenotyping. In spite of freckling being a relatively common pigmentation characteristic in Europeans, little is known about the genetic basis of this largely genetically determined phenotype in southern European populations. In this work, we explored the predictive capacity of eight freckle and sunlight sensitivity-related genes in 458 individuals (266 non-freckled controls and 192 freckled cases) from Spain...
November 23, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/29187256/astrocytes-in-mouse-models-of-tauopathies-acquire-early-deficits-and-lose-neurosupportive-functions
#6
Marta Sidoryk-Wegrzynowicz, Yannick N Gerber, Miriam Ries, Magdalena Sastre, Aviva M Tolkovsky, Maria Grazia Spillantini
Microtubule-associated protein tau aggregates constitute the characteristic neuropathological features of several neurodegenerative diseases grouped under the name of tauopathies. It is now clear that the process of tau aggregation is associated with neurodegeneration. Several transgenic tau mouse models have been developed where tau progressively aggregates, causing neuronal death. Previously we have shown that transplantation of astrocytes in P301S tau transgenic mice rescues cortical neuron death, implying that the endogenous astrocytes are deficient in survival support...
November 29, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29182709/the-rosas-cohort-a-prospective-longitudinal-study-of-biomarkers-for-alzheimer-s-disease-strategy-methods-and-initial-results
#7
A de Mauléon, M Soto, V Kiyasova, J Delrieu, I Guignot, S Galtier, M Lilamand, C Cantet, F Lala, N Sastre, S Andrieu, M Pueyo, P J Ousset, B Vellas
OBJECTIVE: The aims of the Research Of biomarkers in Alzheimer's diseaSe (ROSAS) study were to determine the biofluid and imaging biomarkers permitting an early diagnosis of Alzheimer's disease and better characterisation of cognitive and behavioural course of the pathology. This paper outlines the overall strategy, methodology of the study, baseline characteristics of the population and first longitudinal results from the ROSAS cohort. METHODS: Longitudinal prospective monocentric observational study performed at the Alzheimer's disease Research centre in Toulouse...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/29181719/environmental-biotechnology-and-engineering-crucial-tools-for-improving-and-caring-for-the-environment-and-the-quality-of-life-of-modern-societies
#8
EDITORIAL
Héctor M Poggi-Varaldo, Damien A Devault, Hervé Macarie, Isabel Sastre-Conde
No abstract text is available yet for this article.
November 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29180923/corrigendum-to-impact-of-reference-change-value-rcv-based-autoverification-on-turnaround-time-and-physician-satisfaction
#9
Esther Fernández-Grande, Carolina Varela-Rodriguez, Luis Sáenz-Mateos, Amparo Sastre-Gómez, Pilar García-Chico, Teodoro J Palomino-Muñoz
[This corrects the article DOI: 10.11613/BM.2017.037.].
October 15, 2017: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29155204/reciprocal-contribution-of-clinical-studies-and-the-hp10-antigen-elisa-for-the-diagnosis-of-extraparenchymal-neurocysticercosis
#10
R Michael E Parkhouse, Arturo Carpio, Alfredo Campoverde, Patricia Sastre, Glenda Rojas, María Milagros Cortez
To evaluate diagnosis of active neurocysticercosis, paired cerebral spinal fluid (CSF) and serum samples from 24 neurocysticercosis (NCC) patients and 17 control neurological patients were assayed in the HP10 Taenia antigen (Ag) ELISA. The CSF samples were also tested with an HP10 Lateral Flow Assay (LFA). The HP10 Ag was detected by ELISA in the CSF of 5/5 patients with Definitive extraparenchymal NCC, and in 4/5 of the corresponding sera. In the Definitive parenchymal group, on the other hand, the HP10 Ag was absent in 2/3 CSF (with a very low value in the one positive sample) and all the corresponding serum samples...
November 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29145602/genotype-based-selection-of-treatment-for-patients-with-advanced-colorectal-cancer-seticc-a-pharmacogenetic-based-randomized-phase-ii-trial
#11
A Abad, E Martínez-Balibrea, J M Viéitez, V A Orduña, P García Alfonso, J L Manzano, B Massutí, M Benavides, A Carrato, M Zanui, J Gallego, C Grávalos, V Conde, M Provencio, M Valladares, R Salazar, J Sastre, C Montagut, F Rivera, E Aranda
Background: There has been little progress toward personalized therapy for patients with metastatic colorectal cancer (mCRC). TYMS-3' untranslated region (UTR) 6 bp ins/del and ERCC1-118C/T polymorphisms were previously reported to facilitate selecting patients for fluoropyrimidine-based treatment in combination with oxaliplatin as first-line therapy. We assessed the utility of these markers in selecting therapy for patients with mCRC. Patients and methods: This randomized, open-label phase II trial compared bevacizumab plus XELOX (control) versus treatment tailored according to TYMS-3'UTR 6 bp ins/del and ERCC1-118C/T polymorphisms...
November 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29143353/prospective-study-of-concordance-between-hysterosalpingo-contrast-sonography-and-hysteroscopy-for-evaluation-of-the-uterine-cavity-in-patients-undergoing-infertility-studies
#12
Laura Calles-Sastre, Virginia Engels-Calvo, Mar Ríos-Vallejo, Lucia Serrano-González, Manuel García-Espantaleón, Ana Royuela, Reyes De la Cuesta, Tirso Pérez-Medina
OBJECTIVES: The purpose of the study was to assess the accuracy of hysterosalpingo-contrast sonography (HyCoSy) for evaluation of the uterine cavity. METHODS: Hysterosalpingo-contrast sonography was compared with hysteroscopy for assessment of the uterine cavity. This work was a descriptive prospective study to assess the concordance between pathologic intrauterine findings using the Cohen κ coefficient. Ninety infertile patients from Puerta de Hierro University Hospital were included in the study...
November 16, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29141963/current-and-new-challenges-in-occupational-lung-diseases
#13
REVIEW
Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard
Occupational lung diseases are an important public health issue and are avoidable through preventive interventions in the workplace. Up-to-date knowledge about changes in exposure to occupational hazards as a result of technological and industrial developments is essential to the design and implementation of efficient and effective workplace preventive measures. New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29126611/diaphragmatic-thickness-ratio-inspiratory-expiratory-as-a-diagnostic-method-of-diaphragmatic-palsy-associated-with-interescalene-block
#14
V M López Escárraga, K Dubos España, R H Castillo Bustos, L Peidró, S Sastre, X Sala-Blanch
INTRODUCTION: Diaphragmatic paralysis is a side-effect associated with interscalene block. Thickness index of the diaphragm muscle (inspiratory thickness/expiratory thickness) obtained by ultrasound has recently been introduced in clinical practice for diagnosis of diaphragm muscle atrophy. Our objective was to evaluate this index for the diagnosis of acute phrenic paresis associated with interscalene block. PATIENTS AND METHODS: We designed an observational study in 22 patients scheduled for shoulder arthroscopy...
November 7, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29125965/death-by-self-mutilation-after-oral-cannabis-consumption
#15
Clemence Delteil, Caroline Sastre, Marie-Dominique Piercecchi, Catherine Faget-Agius, Marc Deveaux, Pascal Kintz, Marc-Antoine Devooght, George Leonetti, Christophe Bartoli, Anne-Laure Pélissier-Alicot
Major self-mutilation (amputation, castration, self-inflicted eye injuries) is frequently associated with psychiatric disorders and/or substance abuse. A 35-year-old man presented with behavioral disturbances of sudden onset after oral cannabis consumption and major self-mutilation (attempted amputation of the right arm, self-enucleation of both eyes and impalement) which resulted in death. During the enquiry, four fragments of a substance resembling cannabis resin were seized at the victim's home. Autopsy confirmed that death was related to hemorrhage following the mutilations...
November 2, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29108098/high-resolution-crystal-structure-reveals-molecular-details-of-target-recognition-by-the-calcium-dependent-lipopeptide-antibiotic-laspartomycin-c
#16
Laurens H J Kleijn, Hedwich C Vlieg, Thomas M Wood, Javier Sastre Toraño, Bert J C Janssen, Nathaniel Isaac Martin
The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. We here report the crystal structure of the CDA laspartomycin C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28 Å. This represents the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55-P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target...
November 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29102884/effects-of-dietary-2-2-4-4-tetrabromodiphenyl-ether-bde-47-exposure-on-medaka-oryzias-latipes-swimming-behavior
#17
Salvador Sastre, Carlos Fernández Torija, Gregoria Carbonell, José Antonio Rodríguez Martín, Eulalia María Beltrán, Miguel González-Doncel
A diet fortified with 2,2', 4,4'-tetrabromodiphenyl ether (BDE-47: 0, 10, 100, and 1000 ng/g) was dosed to 4-7-day-old post-hatch medaka fish for 40 days to evaluate the effects on the swimming activity of fish using a miniaturized swimming flume. Chlorpyrifos (CF)-exposed fish were selected as the positive control to assess the validity and sensitivity of the behavioral findings. After 20 and 40 days of exposure, the locomotor activity was analyzed for 6 min in a flume section (arena). The CF positive control for each time point were fish exposed to 50 ng CF/ml for 48 h...
November 2, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29101276/lesion-topographies-in-multiple-sclerosis-diagnosis-a-reappraisal
#18
Georgina Arrambide, Mar Tintore, Cristina Auger, Jordi Río, Joaquín Castilló, Angela Vidal-Jordana, Ingrid Galán, Carlos Nos, Manuel Comabella, Raquel Mitjana, Patricia Mulero, Andrea de Barros, Breogán Rodríguez-Acevedo, Luciana Midaglia, Jaume Sastre-Garriga, Alex Rovira, Xavier Montalban
OBJECTIVES: To assess the contributions of cortico-juxtacortical and corpus callosum lesions to multiple sclerosis diagnosis and to compare the value of ≥1 vs ≥3 periventricular lesions in clinically isolated syndromes (CIS). METHODS: Step 1: We evaluated lesion topography classifications in 657 patients with CIS with stepwise Cox proportional hazards regression models considering second attack as the outcome. Step 2: We established 2 dissemination in space (DIS) versions according to the periventricular lesion cutoffs of ≥1 and ≥3 and assessed their performance at 10 years with second attack as the outcome, first individually and then combined with dissemination in time (DIT) in all cases (n = 326), by age, and by CIS topography...
November 3, 2017: Neurology
https://www.readbyqxmd.com/read/29100014/tgf-%C3%AE-induced-quiescence-mediates-chemoresistance-of-tumor-propagating-cells-in-squamous-cell-carcinoma
#19
Jessie A Brown, Yoshiya Yonekubo, Nicole Hanson, Ana Sastre-Perona, Alice Basin, Julie A Rytlewski, Igor Dolgalev, Shane Meehan, Aristotelis Tsirigos, Slobodan Beronja, Markus Schober
Squamous cell carcinomas (SCCs) are heterogeneous tumors sustained by tumor-propagating cancer cells (TPCs). SCCs frequently resist chemotherapy through still unknown mechanisms. Here, we combine H2B-GFP-based pulse-chasing with cell-surface markers to distinguish quiescent from proliferative TPCs within SCCs. We find that quiescent TPCs resist DNA damage and exhibit increased tumorigenic potential in response to chemotherapy, whereas proliferative TPCs undergo apoptosis. Quiescence is regulated by TGF-β/SMAD signaling, which directly regulates cell-cycle gene transcription to control a reversible G1 cell-cycle arrest, independent of p21CIP function...
November 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29098213/single-cell-analysis-of-early-antiviral-gene-expression-reveals-a-determinant-of-stochastic-ifnb1-expression
#20
Sultan Doğanay, Maurice Youzong Lee, Alina Baum, Jessie Peh, Sun-Young Hwang, Joo-Yeon Yoo, Paul J Hergenrother, Adolfo García-Sastre, Sua Myong, Taekjip Ha
RIG-I-like receptors (RLRs) are cytoplasmic sensors of viral RNA that trigger the signaling cascade that leads to type I interferon (IFN) production. Transcriptional induction of RLRs by IFN is believed to play the role of positive feedback to further amplify viral sensing. We found that RLRs and several other IFN-stimulated genes (ISGs) are induced early in viral infection independent of IFN. Expression of these early ISGs requires IRF3/IRF7 and is highly correlated amongst them. Simultaneous detection of mRNA of IFNB1, viral replicase, and ISGs revealed distinct populations of IFNB1 expressing and non-expressing cells which are highly correlated with the levels of early ISGs but are uncorrelated with IFN-dependent ISGs and viral gene expression...
November 13, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
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