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https://www.readbyqxmd.com/read/28335381/computational-prediction-of-the-protonation-sites-of-ac-lys-ala-n-lys-nh2-peptides-through-conceptual-dft-descriptors
#1
Sebastián Sastre, Juan Frau, Daniel Glossman-Mitnik
Six density functionals (M11, M11L, MN12L, MN12SX, N12, and N12SX) in connection with the Def2TZVP basis set and the SMD solvation model (water as a solvent) have been assessed for the calculation of the molecular structure and properties of several peptides with the general formulaAc-Lys-(Ala)n-Lys-NH2,withn=0to5  [...].
March 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28301287/spinal-cord-lesions-a-modest-contributor-to-diagnosis-in-clinically-isolated-syndromes-but-a-relevant-prognostic-factor
#2
Georgina Arrambide, Alex Rovira, Jaume Sastre-Garriga, Carmen Tur, Joaquín Castilló, Jordi Río, Angela Vidal-Jordana, Ingrid Galán, Breogán Rodríguez-Acevedo, Luciana Midaglia, Carlos Nos, Patricia Mulero, Maria Jesús Arévalo, Manuel Comabella, Elena Huerga, Cristina Auger, Xavier Montalban, Mar Tintore
BACKGROUND: The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial. OBJECTIVE: To assess the value of SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual in CIS. METHODS: Concerning SC lesions and MS diagnosis (2010 McDonald), adjusted Cox regression analyses were performed in increasingly specific CIS groups: all cases ( n = 207), non-SC CIS ( n = 143), non-SC CIS with abnormal brain MRI ( n = 90) and non-SC CIS with abnormal brain MRI not fulfilling 2010 MS ( n = 67)...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28287331/disability-progression-markers-over-6-12%C3%A2-years-in-interferon-%C3%AE-treated-multiple-sclerosis-patients
#3
Jordi Río, Àlex Rovira, Mar Tintoré, Susana Otero-Romero, Manuel Comabella, Ángela Vidal-Jordana, Ingrid Galán, Joaquín Castilló, Georgina Arrambide, Carlos Nos, Carmen Tur, Berta Pujal, Cristina Auger, Jaume Sastre-Garriga, Xavier Montalban
OBJECTIVE: To investigate the association between activity during interferon-beta (IFNβ) therapy and disability outcomes in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: A longitudinal study based on two previously described cohorts of IFNβ-treated RRMS patients was conducted. Patients were classified according to clinical activity after 2 years (clinical cohort) or to clinical and radiological activity after 1 year (magnetic resonance imaging (MRI) cohort)...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28287248/the-pioneer-factor-smed-gata456-1-is-required-for-gut-cell-differentiation-and-maintenance-in-planarians
#4
Alejandro González-Sastre, Nídia De Sousa, Teresa Adell, Emili Saló
How adult stem cells differentiate into different cell types remains one of the most intriguing questions in regenerative medicine. Pioneer factors are transcription factors that can bind to and open chromatin, and are among the first elements involved in cell differentiation. We used the freshwater planarian Schmidtea mediterranea as a model system to study the role of the gata456 family of pioneer factors in gut cell differentiation during both regeneration and maintenance of the digestive system. Our findings reveal the presence of two members of the gata456 family in the Schmidtea mediterranea genome; Smed-gata456-1 and Smed-gata456-2...
2017: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/28280608/prognostic-influence-of-histopathological-regression-patterns-in-rectal-adenocarcinoma-receiving-neoadjuvant-therapy
#5
Ma Jesús Fernández-Aceñero, Lourdes Estrada Muñoz, Javier Sastre Varela, Juan Antonio Corona Sánchez, Cristina Díaz Del Arco, Beatriz García Paredes, Sofía Córdoba Largo, Laura Del Puerto Nevado
BACKGROUND: Neoadjuvant chemoradiation therapy (CRT) is an important management strategy in rectal carcinoma. Different systems grading response have shown varying prognostic influence. METHODS: To analyze the prognostic influence of pathological response in a series of 183 patients with rectal carcinoma receiving neoadjuvant therapy. To determine the prognostic significance of the histopathological patterns of response. RESULTS: A total of 183 patients from two hospitals...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28279690/-early-clinical-trials-in-paediatric-oncology-in-spain-a-nationwide-perspective
#6
Francisco Bautista, Soledad Gallego, Adela Cañete, Jaume Mora, Cristina Díaz de Heredia, Ofelia Cruz, José María Fernández, Susana Rives, Pablo Berlanga, Raquel Hladun, Antonio Juan Ribelles, Luis Madero, Manuel Ramírez, Rafael Fernández Delgado, Antonio Pérez-Martínez, Cristina Mata, Anna Llort, Javier Martín Broto, María Elena Cela, Gema Ramírez, Constantino Sábado, Tomás Acha, Itziar Astigarraga, Ana Sastre, Ascensión Muñoz, Mercedes Guibelalde, Lucas Moreno
INTRODUCTION: Cancer is the leading cause of death between the first year of life and adolescence, and some types of diseases are still a major challenge in terms of cure. There is, therefore, a major need for new drugs. Recent findings in cancer biology open the door to the development of targeted therapies against individual molecular changes, as well as immunotherapy. Promising results in adult anti-cancer drug development have not yet been translated into paediatric clinical practice...
March 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/28278235/a-novel-zika-virus-mouse-model-reveals-strain-specific-differences-in-virus-pathogenesis-and-host-inflammatory-immune-responses
#7
Shashank Tripathi, Vinod R M T Balasubramaniam, Julia A Brown, Ignacio Mena, Alesha Grant, Susana V Bardina, Kevin Maringer, Megan C Schwarz, Ana M Maestre, Marion Sourisseau, Randy A Albrecht, Florian Krammer, Matthew J Evans, Ana Fernandez-Sesma, Jean K Lim, Adolfo García-Sastre
Zika virus (ZIKV) is a mosquito borne flavivirus, which was a neglected tropical pathogen until it emerged and spread across the Pacific Area and the Americas, causing large human outbreaks associated with fetal abnormalities and neurological disease in adults. The factors that contributed to the emergence, spread and change in pathogenesis of ZIKV are not understood. We previously reported that ZIKV evades cellular antiviral responses by targeting STAT2 for degradation in human cells. In this study, we demonstrate that Stat2-/- mice are highly susceptible to ZIKV infection, recapitulate virus spread to the central nervous system (CNS), gonads and other visceral organs, and display neurological symptoms...
March 9, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28271853/a-3-year-multi-food-study-of-the-presence-and-persistence-of-listeria-monocytogenes-in-54-small-food-businesses-in-ireland
#8
Dara Leong, Kerrie NicAogáin, Laura Luque-Sastre, Oisin McManamon, Karen Hunt, Avelino Alvarez-Ordóñez, Johann Scollard, Achim Schmalenberger, Séamus Fanning, Conor O'Byrne, Kieran Jordan
The problem of assessing the occurrence of the food-borne pathogen Listeria monocytogenes in the food chain, and therefore the risk of exposure of the human population, is often challenging because of the limited scope of some studies. In this study the occurrence of L. monocytogenes in food from four major food groups, dairy products, meats, seafood and vegetables, and associated food processing environments in Ireland was studied over a three-year period. Fifty-four small food businesses participated in the study and sent both food and environmental samples every 2months between 2013 and 2015...
February 21, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28256687/-reliability-and-stability-in-the-diagnosis-of-high-intellectual-capacity
#9
S Sastre-Riba, A Castello-Tarrida
INTRODUCTION: From a differential perspective it is essential to identify high intellectual capacity (HIC) as a valuable personal and social resource. A valid, stable and reliable metric approach is needed that prevents both false positives and non-detection, thus facilitating the planning and implementation of educational intervention programmes that enable the individual to express his or her personal well-being and potential. AIM: To explore the reliability and stability of the metric approach to HIC at different times of measurement...
February 24, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28248984/multi-arm-cost-effectiveness-analysis-cea-comparing-different-durations-of-adjuvant-trastuzumab-in-early-breast-cancer-from-the-english-nhs-payer-perspective
#10
Caroline S Clarke, Rachael M Hunter, Ian Shemilt, Victoria Serra-Sastre
BACKGROUND: Trastuzumab improves survival in HER2+ breast cancer patients, with some evidence of adverse cardiac side effects. Current recommendations are to give adjuvant trastuzumab for one year or until recurrence, although trastuzumab treatment for only 9 or 10 weeks has shown similar survival rates to 12-month treatment. We present here a multi-arm joint analysis examining the relative cost-effectiveness of different durations of adjuvant trastuzumab. METHODS AND FINDINGS: Network meta-analysis (NMA) was used to examine which trials' data to include in the cost-effectiveness analysis (CEA)...
2017: PloS One
https://www.readbyqxmd.com/read/28248290/systems-based-analysis-of-rig-i-dependent-signalling-identifies-khsrp-as-an-inhibitor-of-rig-i-receptor-activation
#11
Stephen Soonthornvacharin, Ariel Rodriguez-Frandsen, Yingyao Zhou, Felipe Galvez, Nicholas J Huffmaster, Shashank Tripathi, Vinod R M T Balasubramaniam, Atsushi Inoue, Elisa de Castro, Hong Moulton, David A Stein, María Teresa Sánchez-Aparicio, Paul D De Jesus, Quy Nguyen, Renate König, Nevan J Krogan, Adolfo García-Sastre, Sunnie M Yoh, Sumit K Chanda
Retinoic acid-inducible gene I (RIG-I) receptor recognizes 5'-triphosphorylated RNA and triggers a signalling cascade that results in the induction of type-I interferon (IFN)-dependent responses. Its precise regulation represents a pivotal balance between antiviral defences and autoimmunity. To elucidate the cellular cofactors that regulate RIG-I signalling, we performed two global RNA interference analyses to identify both positive and negative regulatory nodes operating on the signalling pathway during virus infection...
March 1, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28235968/advanced-practice-nursing-competency-assessment-instrument-apncai-clinimetric-validation
#12
Pedro Sastre-Fullana, Jose Miguel Morales-Asencio, Albert Sesé-Abad, Miquel Bennasar-Veny, Juan Carlos Fernández-Domínguez, Joan De Pedro-Gómez
OBJECTIVE: To describe the development and clinimetric validation of the Advanced Practice Nursing Competency Assessment Instrument (APNCAI) through several evidence sources about reliability and validity in the Spanish context. DESIGN AND SETTING: APNCAI development was based on a multisequential and systematic process: literature review, instrument content consensus through qualitative Delphi method approach (a panel of 51 Advanced Practice in Nursing -APN- experts was selected) and the clinimetric validation process based on a sample of 600 nurses from the Balearic Islands public healthcare setting...
February 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28229438/-new-areas-new-challenges
#13
EDITORIAL
J Sastre-Garriga
No abstract text is available yet for this article.
March 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28211351/quality-indicators-of-asthma-care-derived-from-the-spanish-guidelines-for-asthma-management-gema-4-0-a-multidisciplinary-team-report
#14
S Quirce, J Delgado, L M Entrenas, M Grande, C Llorente, A López Viña, E Martínez Moragón, E Mascarós, J Molina, J M Olaguibel, L A Pérez de Llano, M Perpiñá Tordera, J A Quintano, M Rodríguez, M Román-Rodriguez, J Sastre, J A Trigueros, A L Valero, A C Zoni, V Plaza
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28192418/defining-the-antibody-cross-reactome-directed-against-the-influenza-virus-surface-glycoproteins
#15
Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida, Aldo Barrera, Marcela Ferres, Randy A Albrecht, Adolfo García-Sastre, Nicole M Bouvier, Kimihito Ito, Rafael A Medina, Peter Palese, Florian Krammer
Infection with influenza virus induces antibodies to the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To assess the breadth and magnitude of antibody responses, we sequentially infected mice, guinea pigs and ferrets with divergent H1N1 or H3N2 subtypes of influenza virus. We measured antibody responses by ELISA of an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses...
April 2017: Nature Immunology
https://www.readbyqxmd.com/read/28187322/chronic-aspartame-intake-causes-changes-in-the-trans-sulphuration-pathway-glutathione-depletion-and-liver-damage-in-mice
#16
Isabela Finamor, Salvador Pérez, Caroline A Bressan, Carlos E Brenner, Sergio Rius-Pérez, Patricia C Brittes, Gabriele Cheiran, Maria I Rocha, Marcelo da Veiga, Juan Sastre, Maria A Pavanato
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with aspartame for 90 days; and treated with aspartame plus N-acetylcysteine (NAC)...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28166285/p38%C3%AE-regulates-actin-cytoskeleton-and-cytokinesis-in-hepatocytes-during-development-and-aging
#17
Ana M Tormos, Sergio Rius-Pérez, María Jorques, Patricia Rada, Lorena Ramirez, Ángela M Valverde, Ángel R Nebreda, Juan Sastre, Raquel Taléns-Visconti
BACKGROUND: Hepatocyte poliploidization is an age-dependent process, being cytokinesis failure the main mechanism of polyploid hepatocyte formation. Our aim was to study the role of p38α MAPK in the regulation of actin cytoskeleton and cytokinesis in hepatocytes during development and aging. METHODS: Wild type and p38α liver-specific knock out mice at different ages (after weaning, adults and old) were used. RESULTS: We show that p38α MAPK deficiency induces actin disassembly upon aging and also cytokinesis failure leading to enhanced binucleation...
2017: PloS One
https://www.readbyqxmd.com/read/28165094/exfoliation-and-supramolecular-functionalization-of-graphene-with-an-electron-donor-perylenediimide-derivative
#18
Luis Martín-Gomis, Nikos Karousis, Fernando Fernández-Lázaro, Ioannis D Petsalakis, Kei Ohkubo, Shunichi Fukuzumi, Nikos Tagmatarchis, Ángela Sastre-Santos
The liquid exfoliation of graphite to few layered graphene sheets together with the non-covalent supramolecular functionalization of exfoliated graphene by the synthesized N,N'-di(2-ethylhexyl)-1-(N''''-methylpiperazin-N'''-yl)perylene-3,4,9,10-tetracarboxydiimide (Pip-PDI) is reported. The aromatic Pip-PDI has the ability to non-covalently interact with the exfoliated graphene sheets, stabilizing them and preventing their reassembly. On the other hand, the presence of the piperazine moiety on the bay position of the PDI core makes it an ideal electron donor, nicely coupled with the electron accepting exfoliated graphene, hence, forming a novel donor-acceptor nanoensemble, which was characterized by complementary spectroscopic and microscopy techniques...
February 6, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28152519/kalirin-and-chd7-novel-endothelial-dysfunction-indicators-in-circulating-extracellular-vesicles-from-hypertensive-patients-with-albuminuria
#19
Fernando de la Cuesta, Montserrat Baldan-Martin, Rafael Moreno-Luna, Gloria Alvarez-Llamas, Laura Gonzalez-Calero, Laura Mourino-Alvarez, Tamara Sastre-Oliva, Juan A López, Jesús Vázquez, Gema Ruiz-Hurtado, Julian Segura, Fernando Vivanco, Luis M Ruilope, Maria G Barderas
Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin- System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies.Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28150417/the-ethics-of-postoperative-pain-management-mapping-nurses-views
#20
Maria Dolores Cano Romero, Maria Teresa Muñoz Sastre, Bruno Quintard, Paul C Sorum, Etienne Mullet
AIM: We explored the positions of nurses working in hospitals regarding the acceptability of refusing to give a repeat dose of painkiller to a postoperative patient who requested it. These positions were compared with that of lay people, physicians, and other health professionals. DESIGN AND METHODS: Factorial design was used to assess the impact of 6 situational factors: the patient's age, the current level of pain as assessed by the nurse, the number of requests, the level of risk associated with the administration of a repeat dose, the outcome of surgery, and the giving of alternative mild analgesics...
February 1, 2017: International Journal of Nursing Practice
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