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https://www.readbyqxmd.com/read/28211351/quality-indicators-of-asthma-care-derived-from-the-spanish-guidelines-for-asthma-management-gema-4-0-a-multidisciplinary-team-report
#1
S Quirce, J Delgado, L M Entrenas, M Grande, C Llorente, A López Viña, E Martínez Moragón, E Mascarós, J Molina, J M Olaguibel, L A Pérez de Llano, M Perpiñá Tordera, J A Quintano, M Rodríguez, M Román-Rodriguez, J Sastre, J A Trigueros, A L Valero, A C Zoni, V Plaza
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28192418/defining-the-antibody-cross-reactome-directed-against-the-influenza-virus-surface-glycoproteins
#2
Raffael Nachbagauer, Angela Choi, Ariana Hirsh, Irina Margine, Sayaka Iida, Aldo Barrera, Marcela Ferres, Randy A Albrecht, Adolfo García-Sastre, Nicole M Bouvier, Kimihito Ito, Rafael A Medina, Peter Palese, Florian Krammer
Infection with influenza virus induces antibodies to the viral surface glycoproteins hemagglutinin and neuraminidase, and these responses can be broadly protective. To assess the breadth and magnitude of antibody responses, we sequentially infected mice, guinea pigs and ferrets with divergent H1N1 or H3N2 subtypes of influenza virus. We measured antibody responses by ELISA of an extensive panel of recombinant glycoproteins representing the viral diversity in nature. Guinea pigs developed high titers of broadly cross-reactive antibodies; mice and ferrets exhibited narrower humoral responses...
February 13, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28187322/chronic-aspartame-intake-causes-changes-in-the-trans-sulphuration-pathway-glutathione-depletion-and-liver-damage-in-mice
#3
Isabela Finamor, Salvador Pérez, Caroline A Bressan, Carlos E Brenner, Sergio Rius-Pérez, Patricia C Brittes, Gabriele Cheiran, Maria I Rocha, Marcelo da Veiga, Juan Sastre, Maria A Pavanato
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with aspartame for 90 days; and treated with aspartame plus N-acetylcysteine (NAC)...
February 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28166285/p38%C3%AE-regulates-actin-cytoskeleton-and-cytokinesis-in-hepatocytes-during-development-and-aging
#4
Ana M Tormos, Sergio Rius-Pérez, María Jorques, Patricia Rada, Lorena Ramirez, Ángela M Valverde, Ángel R Nebreda, Juan Sastre, Raquel Taléns-Visconti
BACKGROUND: Hepatocyte poliploidization is an age-dependent process, being cytokinesis failure the main mechanism of polyploid hepatocyte formation. Our aim was to study the role of p38α MAPK in the regulation of actin cytoskeleton and cytokinesis in hepatocytes during development and aging. METHODS: Wild type and p38α liver-specific knock out mice at different ages (after weaning, adults and old) were used. RESULTS: We show that p38α MAPK deficiency induces actin disassembly upon aging and also cytokinesis failure leading to enhanced binucleation...
2017: PloS One
https://www.readbyqxmd.com/read/28165094/exfoliation-and-supramolecular-functionalization-of-graphene-with-an-electron-donor-perylenediimide-derivative
#5
Luis Martín-Gomis, Nikos Karousis, Fernando Fernández-Lázaro, Ioannis D Petsalakis, Kei Ohkubo, Shunichi Fukuzumi, Nikos Tagmatarchis, Ángela Sastre-Santos
The liquid exfoliation of graphite to few layered graphene sheets together with the non-covalent supramolecular functionalization of exfoliated graphene by the synthesized N,N'-di(2-ethylhexyl)-1-(N''''-methylpiperazin-N'''-yl)perylene-3,4,9,10-tetracarboxydiimide (Pip-PDI) is reported. The aromatic Pip-PDI has the ability to non-covalently interact with the exfoliated graphene sheets, stabilizing them and preventing their reassembly. On the other hand, the presence of the piperazine moiety on the bay position of the PDI core makes it an ideal electron donor, nicely coupled with the electron accepting exfoliated graphene, hence, forming a novel donor-acceptor nanoensemble, which was characterized by complementary spectroscopic and microscopy techniques...
February 6, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28152519/kalirin-and-chd7-novel-endothelial-dysfunction-indicators-in-circulating-extracellular-vesicles-from-hypertensive-patients-with-albuminuria
#6
Fernando de la Cuesta, Montserrat Baldan-Martin, Rafael Moreno-Luna, Gloria Alvarez-Llamas, Laura Gonzalez-Calero, Laura Mourino-Alvarez, Tamara Sastre-Oliva, Juan A López, Jesús Vázquez, Gema Ruiz-Hurtado, Julian Segura, Fernando Vivanco, Luis M Ruilope, Maria G Barderas
Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin- System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies.Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28150417/the-ethics-of-postoperative-pain-management-mapping-nurses-views
#7
Maria Dolores Cano Romero, Maria Teresa Muñoz Sastre, Bruno Quintard, Paul C Sorum, Etienne Mullet
AIM: We explored the positions of nurses working in hospitals regarding the acceptability of refusing to give a repeat dose of painkiller to a postoperative patient who requested it. These positions were compared with that of lay people, physicians, and other health professionals. DESIGN AND METHODS: Factorial design was used to assess the impact of 6 situational factors: the patient's age, the current level of pain as assessed by the nurse, the number of requests, the level of risk associated with the administration of a repeat dose, the outcome of surgery, and the giving of alternative mild analgesics...
February 1, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28122896/prognostic-significance-of-venous-thromboembolic-events-in-disseminated-germ-cell-cancer-patients
#8
Enrique Gonzalez-Billalabeitia, Daniel Castellano, Nora Sobrevilla, Josep Guma, David Hervas, Maria I Luengo, Jorge Aparicio, Alfonso Sanchez-Muñoz, Begoña Mellado, Alberto Saenz, Claudia Valverde, Antonio Fernandez, Mireia Margeli, Ignacio Duran, Sara Fernandez, Javier Sastre, Silverio Ros, Pablo Maroto, Ray Manneh, Pablo Cerezuela, Alberto Carmona-Bayonas
BACKGROUND: Disseminated germ cell cancers are at high risk of developing thromboembolic complications. We evaluated the prognostic value of venous thromboembolic events (VTE) in disseminated germ cell cancer.  METHODS: Patients with germ cell cancer receiving upfront platinum-containing chemotherapy between 2004 and 2014 were pooled from the Spanish Germ Cell Cancer Group (SGCCG) registry and reviewed for the presence of VTE. Results were validated in an independent international group of patients...
January 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28112834/multichromophoric-perylenediimide-silicon-phthalocyanine-c60-system-as-an-artificial-photosynthetic-analogue
#9
Luis Martín-Gomis, Francisco Peralta-Ruiz, Michael B Thomas, Fernando Fernández-Lázaro, Francis D'Souza, Ángela Sastre-Santos
Sequential photoinduced energy transfer followed by electron transfer and the formation of charge-separated states, which are primary events of natural photosynthesis, have been demonstrated in a newly synthesized multichromophoric covalently linked triad, PDI-SiPc-C60 . The triad comprises a perylenediimide (PDI), which primarily fulfils antenna and electron-acceptor functionalities, silicon phthalocyanine (SiPc) as an electron donor, and fulleropyrrolidine (C60 ) as a second electron acceptor. The multi-step convergent synthetic procedure developed here produced good yields of the triad and control dyads, PDI-SiPc and SiPc-C60 ...
January 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28109743/regulation-of-human-pol%C3%AE-by-atm-mediated-phosphorylation-during-non-homologous-end-joining
#10
Guillermo Sastre-Moreno, John M Pryor, Marta Moreno-Oñate, Andrés M Herrero-Ruiz, Felipe Cortés-Ledesma, Luis Blanco, Dale A Ramsden, Jose F Ruiz
DNA double strand breaks (DSBs) trigger a variety of cellular signaling processes, collectively termed the DNA-damage response (DDR), that are primarily regulated by protein kinase ataxia-telangiectasia mutated (ATM). Among DDR activated processes, the repair of DSBs by non-homologous end joining (NHEJ) is essential. The proper coordination of NHEJ factors is mainly achieved through phosphorylation by an ATM-related kinase, the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), although the molecular basis for this regulation has yet to be fully elucidated...
January 17, 2017: DNA Repair
https://www.readbyqxmd.com/read/28101294/erratum-to-risk-and-safety-requirements-for-diagnostic-and-therapeutic-procedures-in-allergology-world-allergy-organization-statement
#11
Marek L Kowalski, Ignacio Ansotegui, Werner Aberer, Mona Al-Ahmad, Mubeccel Akdis, Barbara K Ballmer-Weber, Kirsten Beyer, Miguel Blanca, Simon Brown, Chaweewan Bunnag, Arnaldo Capriles Hulett, Mariana Castells, Hiok Hee Chng, Frederic De Blay, Motohiro Ebisawa, Stanley Fineman, David B K Golden, Tari Haahtela, Michael Kaliner, Connie Katelaris, Bee Wah Lee, Joanna Makowska, Ulrich Muller, Joaquim Mullol, John Oppenheimer, Hae-Sim Park, James Parkerson, Giovanni Passalacqua, Ruby Pawankar, Harald Renz, Franziska Rueff, Mario Sanchez-Borges, Joaquin Sastre, Glenis Scadding, Scott Sicherer, Pongsakorn Tantilipikorn, James Tracy, Vera van Kampen, Barbara Bohle, G Walter Canonica, Luis Caraballo, Maximiliano Gomez, Komei Ito, Erika Jensen-Jarolim, Mark Larche, Giovanni Melioli, Lars K Poulsen, Rudolf Valenta, Torsten Zuberbier
[This corrects the article DOI: 10.1186/s40413-016-0122-3.].
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28096299/exosomes-from-eosinophils-autoregulate-and-promote-eosinophil-functions
#12
José Antonio Cañas, Beatriz Sastre, Carla Mazzeo, Mar Fernández-Nieto, José Manuel Rodrigo-Muñoz, Andrés González-Guerra, Manuel Izquierdo, Pilar Barranco, Santiago Quirce, Joaquín Sastre, Victoria Del Pozo
Eosinophils are able to secrete exosomes that have an undefined role in asthma pathogenesis. We hypothesized that exosomes released by eosinophils autoregulate and promote eosinophil function. Eosinophils of patients with asthma (n = 58) and healthy volunteers (n = 16) were purified from peripheral blood, and exosomes were isolated and quantified from eosinophils of the asthmatic and healthy populations. Apoptosis, adhesion, adhesion molecules expression, and migration assays were performed with eosinophils in the presence or absence of exosomes from healthy and asthmatic individuals...
January 17, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28089234/oncogenic-kras-induced-increase-in-fluid-phase-endocytosis-is-dependent-on-n-wasp-and-is-required-for-the-formation-of-pancreatic-preneoplastic-lesions
#13
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M Schmid, Jens T Siveke
Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRas(G12D), which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRas(G12D)-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified mechanism. Using three-dimensional mouse and human acinar tissue cultures and genetically engineered mouse models, we provide evidence that (i) KRas(G12D) leads to EGFR-dependent sustained fluid-phase endocytosis (FPE) during acinar metaplasia; (ii) variations in plasma membrane tension increase FPE and lead to ADM in vitro independently of EGFR; and (iii) that RAC1 regulates ADM formation partially through actin-dependent regulation of FPE...
December 24, 2016: EBioMedicine
https://www.readbyqxmd.com/read/28089097/a-systematic-approach-for-the-chromatographic-fractionation-and-purification-of-major-steroid-saponins-in-commercial-extracts-of-yucca-schidigera-roezl
#14
F Sastre, F Ferreira, F Pedreschi
Yucca schidigera Roezl. (yucca) is one of the major industrial sources of steroid saponins used as animal and human food additives. This work describes a new, systematic and reproducible three-step method by medium and high-pressure liquid chromatography (under RP, NP and RP conditions), for the isolation and purification of three groups of saponins, which were further purified in six sub-fractions, and finally into twelve individual steroid saponins previously reported in Y. schidigera. In accordance to the increasing applications of yucca extracts, further analytical, biological and physicochemical studies are still required...
November 23, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28067239/corrigendum-influenza-virus-mrna-trafficking-through-host-nuclear-speckles
#15
Amir Mor, Alexander White, Ke Zhang, Matthew Thompson, Matthew Esparza, Raquel Muñoz-Moreno, Kazunori Koide, Kristen W Lynch, Adolfo García-Sastre, Beatriz M A Fontoura
No abstract text is available yet for this article.
January 9, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28062361/redox-signaling-in-the-gastrointestinal-tract
#16
REVIEW
Salvador Pérez, Raquel Taléns-Visconti, Sergio Rius-Pérez, Isabela Finamor, Juan Sastre
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells. Furthermore, commensal bacteria contribute to intestine epithelial homeostasis through NOX1- and dual oxidase 2-derived reactive oxygen species (ROS). The loss of redox homeostasis is involved in the pathogenesis and development of a wide diversity of gastrointestinal disorders, such as Barrett's esophagus, esophageal adenocarcinoma, peptic ulcer, gastric cancer, ischemic intestinal injury, celiac disease, inflammatory bowel disease and colorectal cancer...
January 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28059146/influenza-virus-exploits-tunneling-nanotubes-for-cell-to-cell-spread
#17
Amrita Kumar, Jin Hyang Kim, Priya Ranjan, Maureen G Metcalfe, Weiping Cao, Margarita Mishina, Shivaprakash Gangappa, Zhu Guo, Edward S Boyden, Sherif Zaki, Ian York, Adolfo García-Sastre, Michael Shaw, Suryaprakash Sambhara
Tunneling nanotubes (TNTs) represent a novel route of intercellular communication. While previous work has shown that TNTs facilitate the exchange of viral or prion proteins from infected to naïve cells, it is not clear whether the viral genome is also transferred via this mechanism and further, whether transfer via this route can result in productive replication of the infectious agents in the recipient cell. Here we present evidence that lung epithelial cells are connected by TNTs, and in spite of the presence of neutralizing antibodies and an antiviral agent, Oseltamivir, influenza virus can exploit these networks to transfer viral proteins and genome from the infected to naïve cell, resulting in productive viral replication in the naïve cells...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057438/oncogenic-kras-induced-increase-in-fluid-phase-endocytosis-is-dependent-on-n-wasp-and-is-required-for-the-formation-of-pancreatic-preneoplastic-lesions
#18
Clara Lubeseder-Martellato, Katharina Alexandrow, Ana Hidalgo-Sastre, Irina Heid, Sophie Luise Boos, Thomas Briel, Roland M Schmid, Jens T Siveke
Fluid-phase endocytosis is a homeostatic process with an unknown role in tumor initiation. The driver mutation in pancreatic ductal adenocarcinoma (PDAC) is constitutively active KRas(G12D), which induces neoplastic transformation of acinar cells through acinar-to-ductal metaplasia (ADM). We have previously shown that KRas(G12D)-induced ADM is dependent on RAC1 and EGF receptor (EGFR) by a not fully clarified mechanism. Using three-dimensional mouse and human acinar tissue cultures and genetically engineered mouse models, we provide evidence that (i) KRas(G12D) leads to EGFR-dependent sustained fluid-phase endocytosis (FPE) during acinar metaplasia; (ii) variations in plasma membrane tension increase FPE and lead to ADM in vitro independently of EGFR; and (iii) that RAC1 regulates ADM formation partially through actin-dependent regulation of FPE...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28054016/data-set-on-a-study-of-gene-expression-in-peripheral-samples-to-identify-biomarkers-of-severity-of-allergic-and-nonallergic-asthma
#19
Selene Baos, David Calzada, Lucía Cremades, Joaquín Sastre, Joaquín Quiralte, Fernando Florido, Carlos Lahoz, Blanca Cárdaba
This article contains information related to the research article entitled "Biomarkers associated with disease severity in allergic and nonallergic asthma" (S. Baos, D. Calzada, L. Cremades, J. Sastre, J. Quiralte, F. Florido, C. Lahoz, B. Cárdaba, In press). Specifically, the clinical criteria stablished for selecting the study population (n=104 subjects) are described. Moreover, this article describes the criteria for selecting the 94 genes to be analyzed in PBMCs (peripheral blood mononuclear cells), it is provided a description of these genes and a Table with the genes most differentially expressed by clinical phenotypes and, finally it is detailed the experimental methodology followed for studying the protein expression of MSR1 (macrophage scavenger receptor 1), one of the genes evaluated in the research...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/28038922/oct-angiography-in-retinal-arterial-macroaneurysm
#20
P Gili Manzanaro, H Santiago-Balsera, I Velasco Sastre
No abstract text is available yet for this article.
December 27, 2016: Archivos de la Sociedad Española de Oftalmología
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