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https://www.readbyqxmd.com/read/27895186/correction-for-eduardo-correia-et-al-isg15-is-counteracted-by-vaccinia-virus-e3-protein-and-controls-the-proinflammatory-response-against-viral-infection
#1
Benedito Eduardo-Correia, Carles Martínez-Romero, Adolfo García-Sastre, Susana Guerra
No abstract text is available yet for this article.
December 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27894957/dna-methylation-profiling-identifies-ptrf-cavin-1-as-a-novel-tumor-suppressor-in-ewing-sarcoma-when-co-expressed-with-caveolin-1
#2
Juan Huertas-Martínez, Franck Court, Santiago Rello-Varona, David Herrero-Martín, Olga Almacellas-Rabaiget, Miguel Sáinz-Jaspeado, Silvia Garcia-Monclús, Laura Lagares-Tena, Raquel Buj, Lourdes Hontecillas-Prieto, Ana Sastre, Daniel Azorin, Xavier Sanjuan, Roser López-Alemany, Sebastian Moran, Josep Roma, Soledad Gallego, Jaume Mora, Xavier García Del Muro, Paloma H Giangrande, Miquel A Peinado, Javier Alonso, Enrique de Alava, Dave Monk, Manel Esteller, Oscar M Tirado
Epigenetic modifications have been shown to be important in developmental tumors as Ewing sarcoma. We profiled the DNA methylation status of 15 primary tumors, 7 cell lines, 10 healthy tissues and 4 human mesenchymal stem cells lines samples using the Infinium Human Methylation 450k. Differential methylation analysis between Ewing sarcoma and reference samples revealed 1,166 hypermethylated and 864 hypomethylated CpG sites (Bonferroni p<0.05, δ-β-value with absolute difference of >0.20) corresponding to 392 and 470 genes respectively...
November 25, 2016: Cancer Letters
https://www.readbyqxmd.com/read/27890675/synergistic-drug-combination-effectively-blocks-ebola-virus-infection
#3
Wei Sun, Shihua He, Carles Martínez-Romero, Jennifer Kouznetsova, Gregory Tawa, Miao Xu, Paul Shinn, Ethan Fisher, Yan Long, Omid Motabar, Shu Yang, Philip E Sanderson, Peter R Williamson, Adolfo García-Sastre, Xiangguo Qiu, Wei Zheng
Although a group of FDA-approved drugs were previously identified with activity against Ebola virus, most of them are not clinically useful because their human blood concentrations are not high enough to inhibit EBOV infection. We screened 795 unique three-drug combinations in an EBOV entry assay. Two sets of three-drug combinations, toremifene-mefloquine-posaconazole and toremifene-clarithromycin-posaconazole, were identified that effectively blocked EBOV entry and were further validated for inhibition of live EBOV infection...
November 24, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27884876/measurement-of-cortical-thickness-and-volume-of-subcortical-structures-in-multiple-sclerosis-agreement-between-2d-spin-echo-and-3d-mprage-t1-weighted-images
#4
A Vidal-Jordana, D Pareto, J Sastre-Garriga, C Auger, E Ciampi, X Montalban, A Rovira
BACKGROUND AND PURPOSE: Gray matter pathology is known to occur in multiple sclerosis and is related to disease outcomes. FreeSurfer and the FMRIB Integrated Registration and Segmentation Tool (FIRST) have been developed for measuring cortical and subcortical gray matter in 3D-gradient-echo T1-weighted images. Unfortunately, most historical MS cohorts do not have 3D-gradient-echo, but 2D-spin-echo images instead. We aimed to evaluate whether cortical thickness and the volume of subcortical structures measured with FreeSurfer and FIRST could be reliably measured in 2D-spin-echo images and to investigate the strength and direction of clinicoradiologic correlations...
November 24, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/27875634/the-stringent-response-plays-a-key-role-in-bacillus-subtilis-survival-of-fatty-acid-starvation
#5
A A Pulschen, D E Sastre, F Machinandiarena, A Crotta Asis, D Albanesi, D de Mendoza, F J Gueiros-Filho
The stringent response is a universal adaptive mechanism to protect bacteria from nutritional and environmental stresses. The role of the stringent response during lipid starvation has been studied only in Gram-negative bacteria. Here we report that the stringent response also plays a crucial role in the adaptation of the model Gram-positive Bacillus subtilis to fatty acid starvation. B. subtilis lacking all three (p)ppGpp-synthetases (RelBs , RelP and RelQ) or bearing a RelBs variant that no longer synthesizes (p)ppGpp suffer extreme loss of viability upon lipid starvation...
November 22, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27863976/postoperative-hyperglycaemia-control-reduces-postoperative-complications-in-patients-subject-to-total-knee-arthroplasty
#6
Diego Reátegui, Eduard Tornero, Dragos Popescu, Sergi Sastre, Miquel Camafort, Gracia Gines, Andrés Combalía, Luis Lozano
BACKGROUND: The aim of our study was the early detection and treatment of patients with unknown alterations of the hydrocarbon metabolism subject to total knee arthroplasty in order to reduce the incidence of postoperative complications. METHODS: Patients were classified as non-diabetic patients (group 1), diabetic patients (group 2) and patients with stress hyperglycaemia (group 3). The last two groups were recommended assessment by a primary care physician (PCP)...
November 15, 2016: Knee
https://www.readbyqxmd.com/read/27834188/quality-indicators-of-asthma-care-derived-from-the-spanish-guideline-for-asthma-management-gema-4-0-a-multidisciplinary-team-report
#7
S Quirce, J Delgado, J L Entrenas, M Grande, C Llorente, A López Viña, E Martínez Moragón, E Mascarós, J Molina, J M Olaguibel, L A Pérez de Llano, M Perpiñá Tordera, J A Quintano, M Rodríguez, M Román-Rodriguez, J Sastre, J A Trigueros, A L Valero, A C Zoni, V Plaza
No abstract text is available yet for this article.
November 11, 2016: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/27833609/a-case-of-il-7r-deficiency-caused-by-a-novel-synonymous-mutation-and-implications-for-mutation-screening-in-scid-diagnosis
#8
Fernando Gallego-Bustos, Valer Gotea, José T Ramos-Amador, Rebeca Rodríguez-Pena, Juana Gil-Herrera, Ana Sastre, Aitor Delmiro, Ghadi Rai, Laura Elnitski, Luis I González-Granado, Luis M Allende
Reported synonymous substitutions are generally non-pathogenic, and rare pathogenic synonymous variants may be disregarded unless there is a high index of suspicion. In a case of IL7 receptor deficiency severe combined immunodeficiency (SCID), the relevance of a non-reported synonymous variant was only suspected through the use of additional in silico computational tools, which focused on the impact of mutations on gene splicing. The pathogenic nature of the variant was confirmed using experimental validation of the effect on mRNA splicing and IL7 pathway function...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27807226/subcellular-localizations-of-rig-i-trim25-and-mavs-complexes
#9
M T Sánchez-Aparicio, J Ayllón, A Leo-Macias, T Wolff, A García-Sastre
: The RIG-I signaling pathway is essential for the recognition of viruses and the initiation of host IFN-mediated antiviral responses. Once activated, RIG-I interacts with polyubiquitin chains generated by TRIM25 and binds MAVS, leading to the production of type I IFN. We now show specific interactions among these key partners in the RLR pathway, through the use of Bimolecular Fluorescence Complementation (BiFC) and super resolution microscopy. Dimers of RIG-I, TRIM25 and MAVS localize into different compartments...
November 2, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27803206/effect-of-a-person-centered-course-on-the-empathic-ability-of-dental-students
#10
Julien Rosenzweig, Alessandra Blaizot, Nancie Cougot, Estelle Pegon-Machat, Olivier Hamel, Nareg Apelian, Christophe Bedos, Maria-Teresa Munoz-Sastre, Jean-Noel Vergnes
Person-centered or patient-centered care (PCC) focuses on the individual's needs and concerns. Although PCC is widely acknowledged as a core value of modern medicine, there has been a lack of research on how dental curricula could engage future dentists in PCC approaches. The aim of this study was to assess the impact of a PCC course on empathy in dental students. A controlled study was conducted with fourth-year dental students in four dental faculties in France in 2014-15. The test group (n=63) received 20 hours of PCC training including arts-based approaches, narrative dentistry activities, and workshops on communication based on the Calgary-Cambridge guide...
November 2016: Journal of Dental Education
https://www.readbyqxmd.com/read/27802314/detection-prevalence-and-phylogenetic-relationships-of-demodex-spp-and-further-skin-prostigmata-mites-acari-arachnida-in-wild-and-domestic-mammals
#11
Natalia Sastre, Olga Francino, Joseph N Curti, Tiffany C Armenta, Devaughn L Fraser, Rochelle M Kelly, Erin Hunt, Katja Silbermayr, Christine Zewe, Armand Sánchez, Lluís Ferrer
This study was conceived to detect skin mites in social mammals through real-time qPCR, and to estimate taxonomic Demodex and further Prostigmata mite relationships in different host species by comparing sequences from two genes: mitochondrial 16S rRNA and nuclear 18S rRNA. We determined the mite prevalence in the hair follicles of marmots (13%) and bats (17%). The high prevalence found in marmots and bats by sampling only one site on the body may indicate that mites are common inhabitants of their skin. Since we found three different mites (Neuchelacheles sp, Myobia sp and Penthaleus sp) in three bat species (Miotis yumanensis, Miotis californicus and Corynorhinus townsendii) and two different mites (both inferred to be members of the Prostigmata order) in one marmot species (Marmota flaviventris), we tentatively concluded that these skin mites 1) cannot be assigned to the same genus based only on a common host, and 2) seem to evolve according to the specific habitat and/or specific hair and sebaceous gland of the mammalian host...
2016: PloS One
https://www.readbyqxmd.com/read/27798150/epigenetic-regulation-of-early-and-late-response-genes-in-acute-pancreatitis
#12
Juan Sandoval, Javier Pereda, Salvador Pérez, Isabela Finamor, Azahara Vallet-Sánchez, José Luis Rodríguez, Luis Franco, Juan Sastre, Gerardo López-Rodas
Chromatin remodeling seems to regulate the patterns of proinflammatory genes. Our aim was to provide new insights into the epigenetic mechanisms that control transcriptional activation of early- and late-response genes in initiation and development of severe acute pancreatitis as a model of acute inflammation. Chromatin changes were studied by chromatin immunoprecipitation analysis, nucleosome positioning, and determination of histone modifications in promoters of proinflammatory genes in vivo in the course of taurocholate-induced necrotizing pancreatitis in rats and in vitro in rat pancreatic AR42J acinar cells stimulated with taurocholate or TNF-α...
October 19, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27797403/light-harvesting-phthalocyanine-diketopyrrolopyrrole-derivatives-synthesis-spectroscopic-electrochemical-and-photochemical-studies
#13
Desiré Molina, Mohamed E El-Khouly, Maged El-Kemary, Shunichi Fukuzumi, Fernando Fernández-Lázaro, Ángela Sastre-Santos
A new family of light-harvesting zinc phthalocyanine (ZnPc)-diketopyrrolopyrrole (DPP) hybrids have been synthesized and characterized. The absorption spectral measurements showed that the major absorptions of DPP (450-600 nm) are complementary to those of zinc phthalocyanine (300-400 and 600-700 nm). Therefore, the designed hybrids absorb over a broad range in the visible region. The geometric and electronic structures of the dyads were probed by initio B3LYP/6-311G methods. The majority of the HOMOs were found to be located on the ZnPc, while the majority of the LUMOs were on the DPP units...
October 31, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27791106/synthetically-derived-bat-influenza-a-like-viruses-reveal-a-cell-type-but-not-species-specific-tropism
#14
Étori Aguiar Moreira, Samira Locher, Larissa Kolesnikova, Hardin Bolte, Teresa Aydillo, Adolfo García-Sastre, Martin Schwemmle, Gert Zimmer
Two novel influenza A-like viral genome sequences have recently been identified in Central and South American fruit bats and provisionally designated "HL17NL10" and "HL18NL11." All efforts to isolate infectious virus from bats or to generate these viruses by reverse genetics have failed to date. Recombinant vesicular stomatitis virus (VSV) encoding the hemagglutinin-like envelope glycoproteins HL17 or HL18 in place of the VSV glycoprotein were generated to identify cell lines that are susceptible to bat influenza A-like virus entry...
October 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27791018/ppar%C3%AE-coactivator-1%C3%AE-gene-transfer-reduces-neuronal-loss-and-amyloid-%C3%AE-generation-by-reducing-%C3%AE-secretase-in-an-alzheimer-s-disease-model
#15
Loukia Katsouri, Yau M Lim, Katrin Blondrath, Ioanna Eleftheriadou, Laura Lombardero, Amy M Birch, Nazanin Mirzaei, Elaine E Irvine, Nicholas D Mazarakis, Magdalena Sastre
Current therapies for Alzheimer's disease (AD) are symptomatic and do not target the underlying Aβ pathology and other important hallmarks including neuronal loss. PPARγ-coactivator-1α (PGC-1α) is a cofactor for transcription factors including the peroxisome proliferator-activated receptor-γ (PPARγ), and it is involved in the regulation of metabolic genes, oxidative phosphorylation, and mitochondrial biogenesis. We previously reported that PGC-1α also regulates the transcription of β-APP cleaving enzyme (BACE1), the main enzyme involved in Aβ generation, and its expression is decreased in AD patients...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27777642/risk-and-safety-requirements-for-diagnostic-and-therapeutic-procedures-in-allergology-world-allergy-organization-statement
#16
Marek L Kowalski, Ignacio Ansotegui, Werner Aberer, Mona Al-Ahmad, Mubeccel Akdis, Barbara K Ballmer-Weber, Kirsten Beyer, Miguel Blanca, Simon Brown, Chaweewan Bunnag, Arnaldo Capriles Hulett, Mariana Castells, Hiok Hee Chng, Frederic De Blay, Motohiro Ebisawa, Stanley Fineman, David B K Golden, Tari Haahtela, Michael Kaliner, Connie Katelaris, Bee Wah Lee, Joanna Makowska, Ulrich Muller, Joaquim Mullol, John Oppenheimer, Hae-Sim Park, James Parkerson, Giovanni Passalacqua, Ruby Pawankar, Harald Renz, Franziska Rueff, Mario Sanchez-Borges, Joaquin Sastre, Glenis Scadding, Scott Sicherer, Pongsakorn Tantilipikorn, James Tracy, Vera van Kempen, Barbara Bohle, G Walter Canonica, Luis Caraballo, Maximiliano Gomez, Komei Ito, Erika Jensen-Jarolim, Mark Larche, Giovanni Melioli, Lars K Poulsen, Rudolf Valenta, Torsten Zuberbier
One of the major concerns in the practice of allergy is related to the safety of procedures for the diagnosis and treatment of allergic disease. Management (diagnosis and treatment) of hypersensitivity disorders involves often intentional exposure to potentially allergenic substances (during skin testing), deliberate induction in the office of allergic symptoms to offending compounds (provocation tests) or intentional application of potentially dangerous substances (allergy vaccine) to sensitized patients. These situations may be associated with a significant risk of unwanted, excessive or even dangerous reactions, which in many instances cannot be completely avoided...
2016: World Allergy Organization Journal
https://www.readbyqxmd.com/read/27775306/-endocrine-disrupting-chemicals-exposure-and-other-parental-factors-in-hypospadias-and-cryptorchidism-etiology
#17
B Estors Sastre, P Bragagnini Rodríguez, R Fernández Atuan, R Delgado Alvira, M A Rihuete Heras, J Gracia Romero
AIM OF THE STUDY: To investigate the association between endocrine disrupting chemicals (EDC) exposure and other paternal factors in the etiology of hipospadias and cryptorchidism. METHODS: A case-control study. Cases were infants between 0 and 6 years of age diagnosed with hypospadias or cryptorchidism in our pediatric urology and general pediatric surgery services during a period of 6 months, and controls were infants with the same range of age attending the same services without any urological problem...
July 20, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27775281/-efficacy-of-the-retroperitoneal-assisted-laparoscopic-pyeloplasty-versus-the-mini-posterior-lumbotomy-approach
#18
P Bragagnini Rodríguez, B Stors Sastre, R Fernández Atuan, R Delgado Alvira, M A Rihuete Heras, J Gracia Romero
OBJECTIVE: To evaluate the results of the retroperitoneal-assisted laparoscopic pyeloplasty (RALP) versus the mini posterior lumbotomy pyeloplasty (MPLP). MATERIAL AND METHODS: A retrospective study of 77 patients diagnosed with ureteropelvic junction obstruction between 2007 and 2013 was made, analyzing the surgical technique, complications and results. The anteroposterior pelvic diameter of the kidney, the thickness of the renal parenchyma, the renal function and the morphology of the renogram curve were also evaluated and compared...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
https://www.readbyqxmd.com/read/27773316/a-numerical-model-for-the-study-of-the-difference-frequency-generated-from-nonlinear-mixing-of-standing-ultrasonic-waves-in-bubbly-liquids
#19
María Teresa Tejedor Sastre, Christian Vanhille
The aim of this paper is the study of the behavior of nonlinear standing ultrasonic waves in bubbly liquids and the generation of the difference frequency by nonlinear mixing of several signals. To this end we present a new numerical model based on the finite-volume method and the finite-difference method. This model solves the differential system formed by the wave equation and a Rayleigh-Plesset equation coupling the acoustic pressure field with the bubble vibrations. We consider a resonator filled with a bubbly liquid excited by an ultrasonic pressure source...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27763867/resolution-of-common-variable-immunodeficiency-after-hiv-infection
#20
V Balugo-López, E Hernández García de la Barrera, J Sastre
No abstract text is available yet for this article.
2016: Journal of Investigational Allergology & Clinical Immunology
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