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microRNA, diabetes

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https://www.readbyqxmd.com/read/28529949/microrna-expression-varies-according-to-glucose-tolerance-measurement-platform-and-biological-source
#1
S Dias, S Hemmings, C Muller, J Louw, C Pheiffer
Dysregulated microRNA (miRNA) expression is observed during type 2 diabetes (T2D), although the consistency of miRNA expression across measurement platform and biological source is uncertain. Here we report miRNA profiling in the whole blood and serum of South African women with different levels of glucose tolerance, using next generation sequencing (NGS) and quantitative real time PCR (qRT-PCR). Whole blood-derived miRNAs from women with newly diagnosed T2D (n = 4), impaired glucose tolerance (IGT) (n = 4), and normal glucose tolerance (NGT) (n = 4) were subjected to NGS, whereafter transcript levels of selected miRNAs were quantified in the whole blood and serum of these women using qRT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28520942/emerging-roles-for-micrornas-in-diabetic-microvascular-disease-novel-targets-for-therapy
#2
Yu Zhang, Xinghui Sun, Basak Icli, Mark W Feinberg
Chronic, low-grade systemic inflammation and impaired microvascular function are critical hallmarks in the development of insulin resistance. Accordingly, insulin resistance is a major risk factor for type 2 diabetes and cardiovascular disease. Accumulating studies demonstrate that restoration of impaired function of the diabetic macro- and microvasculature may ameliorate a range of cardiovascular disease states and diabetes-associated complications. In this review, we focus on the emerging role of microRNAs (miRNAs), noncoding RNAs that fine-tune target gene expression and signaling pathways, in insulin-responsive tissues and cell types important for maintaining optimal vascular homeostasis and preventing the sequelae of diabetes-induced end organ injury...
April 1, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28503423/microrna-126-a-promising-novel-biomarker-in-peripheral-blood-for-diabetic-retinopathy
#3
Li-Li Qin, Mei-Xia An, Yan-Li Liu, Han-Chun Xu, Zhi-Qing Lu
AIM: To investigate the content of serum microRNA-126 (miR-126) and its role in screening retinal endothelial injury and early diagnosis of proliferative diabetic retinopathy. METHODS: The study included 184 serum samples, 59 samples from healthy individuals, 44 samples from diabetes mellitus (DM) patients without diabetic retinopathy (NDR), 42 from non-proliferative diabetic retinopathy (NPDR) patients and 39 samples from proliferative diabetic retinopathy (PDR) patients...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28500393/association-of-serum-micrornas-with-islet-autoimmunity-disease-progression-and-metabolic-impairment-in-relatives-at-risk-of-type-1-diabetes
#4
Isaac V Snowhite, Gloria Allende, Jay Sosenko, Ricardo L Pastori, Shari Messinger Cayetano, Alberto Pugliese
AIMS/HYPOTHESIS: MicroRNAs (miRNAs) are key regulators of gene expression and novel biomarkers for many diseases. We investigated the hypothesis that serum levels of some miRNAs would be associated with islet autoimmunity and/or progression to type 1 diabetes. METHODS: We measured levels of 93 miRNAs most commonly detected in serum. This retrospective cohort study included 150 autoantibody-positive and 150 autoantibody-negative family-matched siblings enrolled in the TrialNet Pathway to Prevention Study...
May 12, 2017: Diabetologia
https://www.readbyqxmd.com/read/28498508/stroke-in-women-risk-factors-and-clinical-biomarkers
#5
Hamed Mirzaei
Stroke has been emerged as one of major health problems for women worldwide. Increasing of knowledge in this field provided new data in this area which contribute to finding of new risk factors and could improve stroke treatment. A large number studies indicated a variety of risk factors including sex, age, race, smoking, diabetes, and physical inactivity could be involved in stroke in women. The understanding of various aspects involved in women stroke including risk factors, outcomes, stroke recovery, and prevention could provide new therapeutic platforms which could likely lead to better treatment in women stroke...
May 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28490541/exosomes-as-mediators-of-the-systemic-adaptations-to-endurance-exercise
#6
Adeel Safdar, Mark A Tarnopolsky
Habitual endurance exercise training is associated with multisystemic metabolic adaptations that lower the risk of inactivity-associated disorders such as obesity and type 2 diabetes mellitus (T2DM). Identification of complex systemic signaling networks responsible for these benefits are of great interest because of their therapeutic potential in metabolic diseases; however, specific signals that modulate the multisystemic benefits of exercise in multiple tissues and organs are only recently being discovered...
May 10, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28487136/role-of-micrornas-in-type-2-diabetes-and-associated-vascular-complications
#7
REVIEW
Joyita Banerjee, Vijay Nema, Yogita Dhas, Neetu Mishra
Type 2 diabetes mellitus (T2DM) has become a major health threat worldwide. MicroRNAs (miRNAs) are a group of non-coding RNAs known to regulate various biological processes including the pathogenesis of T2DM. Recent studies have pointed out that specific miRNAs play a critical role in controlling β cell activities and the development of diabetic vascular complications. Their association with the disease pathogenesis and omnipresence in body fluids have made them important players for prognosis, diagnosis and management of T2DM...
May 6, 2017: Biochimie
https://www.readbyqxmd.com/read/28467989/mir-338-3p-mediates-tnf-a-induced-hepatic-insulin-resistance-by-targeting-pp4r1-to-regulate-pp4-expression
#8
Lin Dou, Shuyue Wang, Libo Sun, Xiuqing Huang, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Weiqing Tang, Jian Li
OBJECTIVE: Insulin resistance is a critical factor contributing to the pathogenesis of type 2 diabetes and other metabolic diseases. Recent studies have indicated that miR-338-3p plays an important role in cancer. Here, we investigated whether miR-338-3p mediates tumour necrosis factor-α (TNF-α)-induced hepatic insulin resistance. METHODS: The activation of the insulin signalling pathway and the level of glycogenesis were examined in the livers of the db/db and high fat diet (HFD)-fed mice and in HEP1-6 cells transfected with miR-338-3p mimic or inhibitor...
May 3, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28465657/the-microrna-21-signaling-pathway-is-involved-in-prorenin-receptor-prr-induced-vegf-expression-in-arpe-19-cells-under-a-hyperglycemic-condition
#9
Rashidul Haque, P Michael Iuvone, Li He, Kimberly Su Chung Choi, Ashley Ngo, Samantha Gokhale, Madiha Aseem, Daniel Park
PURPOSE: MicroRNAs (miRNAs/miRs) are involved in a large number of biological functions and diseases, such as cancer, cardiovascular diseases, and diabetes. MiR-21 has been reported to target Sprouty homolog 1 (SPRY1), SMAD7, and PTEN. In this study, we examined the underlying role of miR-21 in the regulation of prorenin receptor (PRR)-mediated induction of vascular endothelial growth factor (VEGF) expression via targeting SMAD7, SPRY1, and PTEN in a hyperglycemic condition. METHODS: PRR-mediated induction of VEGF under a hyperglycemic condition (high glucose, 33mM) was studied by treating ARPE-19 cells with perindopril (10 µmol/l), which inhibits angiotensin II-mediated signaling...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28465283/expression-of-micrornas-and-target-proteins-in-skeletal-muscle-of-rats-selectively-bred-for-high-and-low-running-capacity
#10
Samuel Pinto, Séverine Lamon, Erin J Stephenson, Ming Kalanon, Jasmine Mikovic, Lauren G Koch, Steven L Britton, John A Hawley, Donny M Camera
Impairments in mitochondrial function and substrate metabolism are implicated in the etiology of obesity and type 2 diabetes. MicroRNAs (miRNAs) can degrade mRNA or repress protein translation and have been implicated in the development of such disorders. We used a contrasting rat model system of selectively bred high- (HCR) or low- (LCR) intrinsic running capacity with established differences in metabolic health to investigate the molecular mechanisms through which miRNAs regulate target proteins mediating mitochondrial function and substrate oxidation processes...
May 2, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28462946/light-inducible-antimir-92a-as-a-therapeutic-strategy-to-promote-skin-repair-in-healing-impaired-diabetic-mice
#11
Tina Lucas, Florian Schäfer, Patricia Müller, Sabine A Eming, Alexander Heckel, Stefanie Dimmeler
MicroRNAs (miRs) are small non-coding RNAs that post-transcriptionally control gene expression. Inhibition of miRs by antisense RNAs (antimiRs) might be a therapeutic option for many diseases, but systemic inhibition can have adverse effects. Here we show that light-activatable antimiRs efficiently and locally restricted target miR activity in vivo. We use an antimiR-92a and establish a therapeutic benefit in diabetic wound healing. AntimiR-92a is modified with photolabile protecting groups, so called 'cages'...
May 2, 2017: Nature Communications
https://www.readbyqxmd.com/read/28458441/erratum-modulation-of-hippocampal-gene-expression-of-microrna-146a-microrna-155-nuclear-factor-kappa-b-inflammatory-signaling-by-troxerutin-in-healthy-and-diabetic-rats
#12
(no author information available yet)
[This corrects the article on p. 675 in vol. 48, PMID: 28066106.].
January 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/28455975/suppression-of-microrna-205-5p-in-human-mesenchymal-stem-cells-improves-their-therapeutic-potential-in-treating-diabetic-foot-disease
#13
Lingyan Zhu, Gongxian Wang, Shane Fischbach, Xiangwei Xiao
Diabetes is a prevalent disease endangering human health, while diabetic foot disease (DF) is one of the most severe complications of diabetes. Mesenchymal stem cells (MSCs) have been used in DF treatment, taking advantage of the differentiation potential of MSCs into endothelial cells and their production and secretion of trophic factors like vascular endothelial growth factor (VEGF). Molecular modification of MSCs to improve their therapeutic effects has been recently applied in treating other diseases, but not yet in DF...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28447068/microrna-21-is-up-regulated-in-adipose-tissue-of-obese-diabetic-subjects
#14
Valeria Guglielmi, Monica D'Adamo, Rossella Menghini, Marina Cardellini, Paolo Gentileschi, Massimo Federici, Paolo Sbraccia
We investigated miR21 expression in omental (OAT) and subcutaneous adipose tissue (SAT) from 16 obese subjects undergoing bariatric surgery. Patients were divided into two age- and BMI-matched groups according to the presence of type 2 diabetes (T2D). miR21 was not differently expressed in OAT and SAT. However, miR21 expression was two folds greater in adipose tissue in patients with T2D. Accordingly, in primary cultures of adipocytes from non diabetic overweight subjects, miR21 expression increased after 24-h exposure to high glucose and insulin...
March 31, 2017: Nutrition and Healthy Aging
https://www.readbyqxmd.com/read/28442786/microrna-30a-regulation-of-epithelial-mesenchymal-transition-in-diabetic-cataracts-through-targeting-snai1
#15
Lu Zhang, Ye Wang, Wenfeng Li, Panagiotis A Tsonis, Zhiyuan Li, Lixin Xie, Yusen Huang
Epithelial-mesenchymal transition (EMT) is a highly conserved and fundamental process in development, fibrosis, and metastasis. During the process, epithelial cells lose their morphology and transcriptional program, and transdifferentiate to mesenchymal cells. It has been reported that lens epithelial cells undergo EMT during cataract formation, and regulation of microRNAs on genes is associated with lens development. However, the molecular mechanisms of this regulation in diabetic cataract still need to be investigated...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28440196/mir-126-as-a-therapeutic-agent-for-diabetes-mellitus
#16
Elham Pishavar, Javad Behravan
Diabetes mellitus (DM) is a metabolic disorder which is characterized by inappropriate hyperglycemia. It is becoming an epidemic disease in developing countries. Diabetic patients are frequently afflicted with a vascular dysfunction and wound healing defect. In spite of intense investigations, over the past 2-3 decades, optimal treatment options and related mechanisms are still unclear. MicroRNAs (miRNAs) are small noncoding RNAs considered as regulators of a vast number of biological processes including endothelial cell function controlling molecular signaling pathways in diabetic pathogenesis...
April 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28439258/diabetic-cardiomyopathy-an-immunometabolic-perspective
#17
REVIEW
Paras K Mishra, Wei Ying, Shyam Sundar Nandi, Gautam K Bandyopadhyay, Kaushik K Patel, Sushil K Mahata
The heart possesses a remarkable inherent capability to adapt itself to a wide array of genetic and extrinsic factors to maintain contractile function. Failure to sustain its compensatory responses results in cardiac dysfunction, leading to cardiomyopathy. Diabetic cardiomyopathy (DCM) is characterized by left ventricular hypertrophy and reduced diastolic function, with or without concurrent systolic dysfunction in the absence of hypertension and coronary artery disease. Changes in substrate metabolism, oxidative stress, endoplasmic reticulum stress, formation of extracellular matrix proteins, and advanced glycation end products constitute the early stage in DCM...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28433754/mir-146a-suppresses-stat3-vegf-pathways-and-reduces-apoptosis-through-il-6-signaling-in-primary-human-retinal-microvascular-endothelial-cells-in-high-glucose-conditions
#18
Eun-Ah Ye, Jena J Steinle
microRNA (miRNA) play critical roles in the pathological processes of diabetic retinopathy, including inflammatory responses, insulin signaling, and angiogenesis. In addition to their regulatory functions on gene expression, miRNA is considered as a potential therapeutic target, as well as a diagnostic marker for many diseases. Our understanding on the pathological mechanisms underlying diabetic retinopathy is still incomplete and additional investigations are required to develop novel therapeutic strategies...
April 26, 2017: Vision Research
https://www.readbyqxmd.com/read/28433632/role-of-microrna-130b-in-placental-pgc-1%C3%AE-tfam-mitochondrial-biogenesis-pathway
#19
Shaoning Jiang, April M Teague, Jeanie B Tryggestad, Steven D Chernausek
Diabetes during pregnancy is associated with abnormal placenta mitochondrial function and increased oxidative stress, which affect fetal development and offspring long-term health. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis and energy metabolism. The molecular mechanisms underlying the regulation of PGC-1α in placenta in the context of diabetes remain unclear. The present study examined the role of microRNA 130b (miR-130b-3p) in regulating PGC-1α expression and oxidative stress in a placental trophoblastic cell line (BeWo)...
June 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28431855/relationship-between-long-noncoding-rnas-and-physiological-risk-factors-of-cardiovascular-disease
#20
REVIEW
Moshen Mazidi, Peter Penson, Anna Gluba-Brzozka, Jacek Rysz, Maciej Banach
Long noncoding ribonucleic acids (lncRNAs) are an important category of noncoding RNAs that play crucial roles in controlling the expression of genes in health and in a range of illnesses including cardiovascular disease. A large body of genetic, experimental, and epidemiologic evidence suggests roles for an increasing number of lncRNAs in the regulation of metabolism, lipid profile, inflammation, and glucose metabolism in type II diabetes. Importantly, it has been suggested that lncRNAs can regulate chromatin alteration, messenger RNA stability, microRNA action, and can control transcription factors...
March 27, 2017: Journal of Clinical Lipidology
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