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https://www.readbyqxmd.com/read/28520858/rapid-tests-for-influenza-respiratory-syncytial-virus-and-other-respiratory-viruses-a-systematic-review-and-meta-analysis
#1
Ahl Bruning, Mmg Leeflang, Jmbw Vos, R Spijker, M D de Jong, K C Wolthers, D Pajkrt
Rapid diagnosis of respiratory virus infections contributes to patient care. This systematic review evaluates the diagnostic accuracy of rapid tests for the detection of respiratory viruses. We searched Medline and EMBASE for studies evaluating these tests against PCR as reference standard. 179 studies were included of which 134 evaluated rapid tests for influenza viruses, 32 for RSV, and 13 for other respiratory viruses. We used the bivariate random effects model for quantitative meta-analysis of the results...
May 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28515720/computational-exploration-of-putative-luxr-solos-in-archaea-and-their-functional-implications-in-quorum-sensing
#2
Akanksha Rajput, Manoj Kumar
LuxR solos are unexplored in Archaea, despite their vital role in the bacterial regulatory network. They assist bacteria in perceiving acyl homoserine lactones (AHLs) and/or non-AHLs signaling molecules for establishing intraspecies, interspecies, and interkingdom communication. In this study, we explored the potential LuxR solos of Archaea from InterPro v62.0 meta-database employing taxonomic, probable function, distribution, and evolutionary aspects to decipher their role in quorum sensing (QS). Our bioinformatics analyses showed that putative LuxR solos of Archaea shared few conserved domains with bacterial LuxR despite having less similarity within proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28500423/physiological-self-regulation-buffers-the-relationship-between-impulsivity-and-externalizing-behaviors-among-nonclinical-adolescents
#3
Michelle A Kuhn, Joshua J Ahles, Jaclyn T Aldrich, Madeline D Wielgus, Amy H Mezulis
Trait impulsivity is a risk factor for rule breaking and aggressive (externalizing) behaviors among nonclinical youth. Buffers of trait-based risk are of practical interest to preventing externalizing behaviors. One such buffer may be the capacity and efforts of a child to self-regulate their physiology. Youth who possess baseline physiological self-regulatory capacities are more likely to maintain adaptive engagement with their environment and may be less prone to impulsively rule break or be aggressive. Similarly, youth who are able to use self-regulatory skills to calm their physiology in times of stress may be less likely to externalize distress...
May 12, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28487993/acinetobacter%C3%A2-baumannii-quorum-sensing-signalling-molecule-induces-the-expression-of-drug-resistance-genes
#4
Yi Dou, Fei Song, Feng Guo, Zengding Zhou, Cailian Zhu, Jun Xiang, Jingning Huan
Quorum-sensing signalling molecules such as N‑acyl homoserine lactones (AHLs) enable certain Gram‑negative bacteria to respond to environmental changes through behaviours, such as biofilm formation and flagellar movement. The present study aimed to identify Acinetobacter baumannii AHLs and assess their influence on antibiotic resistance. A clinical isolate of A. baumannii strain S (AbS) was collected from the wound of a burn patient and high‑performance liquid chromatography and tandem quadrupole or quadrupole time‑of‑flight high‑resolution mass spectrometry was used to identify AbS AHLs...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28486154/insights-into-quorum-quenching-mechanisms-to-control-membrane-biofouling-under-changing-organic-loading-rates
#5
Hira Waheed, Yeyuan Xiao, Imran Hashmi, David Stuckey, Yan Zhou
A quorum quenching (QQ) consortium comprised of both acyl homoserine lactones (AHLs)- and autoinducer-2 (AI-2)-degrading bacteria, either immobilized in polymer-coated alginate beads or in liquid suspension, was examined for fouling control in lab-scale MBRs under both steady and changing organic loading rates (OLRs). Under steady conditions the QQ consortium retarded biofouling by a factor of 3. However, a continuous increase in OLR vastly reduced the effectiveness of QQ bacteria; the biofouling was retarded only by factors of 1...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28482205/effects-of-quorum-quenching-by-ahl-lactonase-on-ahls-protease-motility-and-proteome-patterns-in-aeromonas-veronii-lp-11
#6
Meng Gui, Ruiyun Wu, Lei Liu, Shun Wang, Li Zhang, Pinglan Li
Food spoilage by some bacteria is reported to be regulated by quorum sensing (QS). In this study, a quorum quenching approach was used to investigate the QS regulated phenotypes (growth, protease and motility) and proteins expression in of Aeromonas veronii LP-11, which is a specific spoilage organism of sturgeon. AHL lactonase AiiAAI96 from Bacillus quenched the QS system, probably by enzymatically inactivating the AHLs produced by A. veronii LP-11. After AiiAAI96 treatment, the protease and motility activities of A...
April 19, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28481027/neural-correlates-of-fine-grained-meaning-distinctions-an-fmri-investigation-of-scalar-quantifiers
#7
Jiayu Zhan, Xiaoming Jiang, Stephen Politzer-Ahles, Xiaolin Zhou
Communication involves successfully deriving a speaker's meaning beyond the literal expression. Using fMRI, it was investigated how the listener's brain realizes distinctions between enrichment-based meanings and literal semantic meanings. The neural patterns of the Mandarin scalar quantifier you-de (similar to some in English) which implies the meanings not all and not most via scalar enrichment, with the specific quantifier shao-shu-de (similar to less than half in English) which lexico-semantically encodes the meanings not all and not most, were compared...
May 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28472170/two-serines-in-the-distal-c-terminus-of-the-human-%C3%A3-1-adrenoceptor-determine-%C3%A3-arrestin2-recruitment
#8
Laura Hinz, Andrea Ahles, Benjamin Ruprecht, Bernhard Küster, Stefan Engelhardt
G protein-coupled receptors (GPCRs) undergo phosphorylation at several intracellular residues by G protein-coupled receptor kinases. The resulting phosphorylation pattern triggers arrestin recruitment and receptor desensitization. The exact sites of phosphorylation and their function remained largely unknown for the human β1-adrenoceptor (ADRB1), a key GPCR in adrenergic signal transduction and the target of widely used drugs such as β-blockers. The present study aimed to identify the intracellular phosphorylation sites in the ADRB1 and to delineate their function...
2017: PloS One
https://www.readbyqxmd.com/read/28466642/response-of-power-plant-emissions-to-ambient-temperature-in-the-eastern-united-states
#9
David Abel, Tracey Holloway, Ryan M Kladar, Paul Meier, Doug Ahl, Monica Harkey, Jonathan Patz
Past studies have established strong connections between meteorology and air quality, via chemistry, transport, and natural emissions. A less understood linkage between weather and air quality is the temperature-dependence of emissions from electricity generating units (EGUs), associated with high electricity demand to support building cooling on hot days. This study quantifies the relationship between ambient surface temperatures and EGU air emissions (CO2, SO2, and NOX) using historical data. We find that EGUs in the Eastern U...
May 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28463102/high-intracellular-c-di-gmp-levels-antagonize-quorum-sensing-and-virulence-gene-expression-in-burkholderia-cenocepacia-h111
#10
Nadine Schmid, Angela Suppiger, Elisabeth Steiner, Gabriella Pessi, Volkhard Kaever, Mustafa Fazli, Tim Tolker-Nielsen, Urs Jenal, Leo Eberl
The opportunistic human pathogen Burkholderia cenocepacia H111 uses two chemically distinct signal molecules for controlling gene expression in a cell density-dependent manner: N-acyl-homoserine lactones (AHLs) and cis-2-dodecenoic acid (BDSF). Binding of BDSF to its cognate receptor RpfR lowers the intracellular c-di-GMP level, which in turn leads to differential expression of target genes. In this study we analysed the transcriptional profile of B. cenocepacia H111 upon artificially altering the cellular c-di-GMP level...
May 3, 2017: Microbiology
https://www.readbyqxmd.com/read/28462048/pitfalls-associated-with-evaluating-enzymatic-quorum-quenching-activity-the-case-of-moml-and-its-effect-on-pseudomonas-aeruginosa-and-acinetobacter-baumannii-biofilms
#11
Yunhui Zhang, Gilles Brackman, Tom Coenye
BACKGROUND: The enzymatic degradation of quorums sensing (QS) molecules (called quorum quenching, QQ) has been considered as a promising anti-virulence therapy to treat biofilm-related infections and combat antibiotic resistance. The recently-discovered QQ enzyme MomL has been reported to efficiently degrade different N-acyl homoserine lactones (AHLs) of various Gram-negative pathogens. Here we investigated the effect of MomL on biofilms formed by two important nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii...
2017: PeerJ
https://www.readbyqxmd.com/read/28455333/a-novel-quorum-quenching-enzyme-mediates-antibiotic-resistance
#12
Hiroyuki Kusada, Hideyuki Tamaki, Yoichi Kamagata, Satoshi Hanada, Nobutada Kimura
N-Acylhomoserine lactone acylase (AHL-acylase) is a well-known enzyme responsible for disrupting cell-cell communication (quorum sensing) in bacteria. Here we isolated and characterized a novel and unique AHL-acylase (designated MacQ) from a multidrug-resistant bacterium Acidovorax sp. MR-S7. The purified MacQ protein heterologously expressed in Escherichia coli degraded a wide variety of AHLs ranging from C6 to C14 side chains with or without 3-oxo substitutions. We also observed that AHL-mediated virulence factor production in a plant pathogen Pectobacterium carotovorum was dramatically attenuated by co-culturing with MacQ-overexpressing Escherichia coli, whereas E...
April 28, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28446863/peptides-as-quorum-sensing-molecules-measurement-techniques-and-obtained-levels-in-vitro-and-in-vivo
#13
REVIEW
Frederick Verbeke, Severine De Craemer, Nathan Debunne, Yorick Janssens, Evelien Wynendaele, Christophe Van de Wiele, Bart De Spiegeleer
The expression of certain bacterial genes is regulated in a cell-density dependent way, a phenomenon called quorum sensing. Both Gram-negative and Gram-positive bacteria use this type of communication, though the signal molecules (auto-inducers) used by them differ between both groups: Gram-negative bacteria use predominantly N-acyl homoserine lacton (AHL) molecules (autoinducer-1, AI-1) while Gram-positive bacteria use mainly peptides (autoinducer peptides, AIP or quorum sensing peptides). These quorum sensing molecules are not only involved in the inter-microbial communication, but can also possibly cross-talk directly or indirectly with their host...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28444448/the-5-untranslated-region-of-potato-sbglr-gene-contributes-to-pollen-specific-expression
#14
Yujie Chang, Min Yan, Jingjuan Yu, Dengyun Zhu, Qian Zhao
The 5'UTR of SBgLR enhances gene expression by regulating both its transcription and translation. SBgLR (Solanum tuberosum genomic lysine rich) is a pollen-specific gene in Solanum tuberosum that encodes a microtubule-associated protein. The region from -85 to +180 (transcription start site at +1) was determined to be critical for specific expression in pollen grains. Transient and stable expression assays showed that the 5'UTR (from +1 to +184) enhanced gene expression in all detected tissues of transgenic tobacco...
April 25, 2017: Planta
https://www.readbyqxmd.com/read/28432587/rituximab-methotrexate-procarbazine-vincristine-and-intensified-cytarabine-consolidation-for-primary-central-nervous-system-lymphoma-pcnsl-in-the-elderly-a-loc-network-study
#15
Caroline Houillier, Hervé Ghesquières, Cécile Chabrot, Carole Soussain, Guido Ahle, Sylvain Choquet, Emmanuelle Nicolas-Virelizier, Jacques-Olivier Bay, Jacques Vargaftig, Claude Gaultier, Valérie Touitou, Nadine Martin-Duverneuil, Nathalie Cassoux, Magali Le Garff-Tavernier, Myrto Costopoulos, Pierre Faurie, Khê Hoang-Xuan
Primary CNS lymphoma (PCNSL) is chemosensitive to high-dose methotrexate-based chemotherapy. However, responses in the elderly are short-lasting and outcome is poor. Given that radiotherapy and intensive chemotherapy expose elderly to severe toxicities, alternative consolidation approaches need to be evaluated. In this multicenter study, we retrospectively analyzed consecutive patients with newly-diagnosed PCNSL, aged >60, treated with a (R)-MPV-AAA regimen. The regimen consisted of three 28-day cycles of methotrexate (3...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28425948/characterization-of-n-acyl-homoserine-lactones-in-vibrio-tasmaniensis-lgp32-by-a-biosensor-based-uhplc-hrms-ms-method
#16
Léa Girard, Élodie Blanchet, Laurent Intertaglia, Julia Baudart, Didier Stien, Marcelino Suzuki, Philippe Lebaron, Raphaël Lami
Since the discovery of quorum sensing (QS) in the 1970s, many studies have demonstrated that Vibrio species coordinate activities such as biofilm formation, virulence, pathogenesis, and bioluminescence, through a large group of molecules called N-acyl homoserine lactones (AHLs). However, despite the extensive knowledge on the involved molecules and the biological processes controlled by QS in a few selected Vibrio strains, less is known about the overall diversity of AHLs produced by a broader range of environmental strains...
April 20, 2017: Sensors
https://www.readbyqxmd.com/read/28424524/hqia-a-novel-quorum-quenching-enzyme-which-expands-the-ahl-lactonase-family
#17
Marta Torres, Stéphane Uroz, Rafael Salto, Laure Fauchery, Emilia Quesada, Inmaculada Llamas
The screening of a metagenomic library of 250,000 clones generated from a hypersaline soil (Spain) allowed us to identify a single positive clone which confers the ability to degrade N-acyl homoserine lactones (AHLs). The sequencing of the fosmid revealed a 42,318 bp environmental insert characterized by 46 ORFs. The subcloning of these ORFs demonstrated that a single gene (hqiA) allowed AHL degradation. Enzymatic analysis using purified HqiA and HPLC/MS revealed that this protein has lactonase activity on a broad range of AHLs...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28416858/study-on-e-coli-and-salmonella-biofilms-from-fresh-fruits-and-vegetables
#18
Balagopal Amrutha, Kothandapani Sundar, Prathapkumar Halady Shetty
Foodborne outbreaks associated with fresh fruits and vegetables are on the rise worldwide. Biofilm formation is one of the important traits of pathogens making them strongly attached to substrates as well as express virulence phenotypes. Present study investigates the biofilm forming ability of E. coli and Salmonella sp. isolated from fresh fruits and vegetables. A total of 53 strains, including 35 E. coli and 18 Salmonella sp. isolated from different fruit and vegetable samples were taken into account for the study...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28414213/immobilization-and-stabilization-of-acylase-on-carboxylated-polyaniline-nanofibers-for-highly-effective-antifouling-application-via-quorum-quenching
#19
Jeongjoon Lee, Inseon Lee, Jahyun Nam, Dong Soo Hwang, Kyung-Min Yeon, Jungbae Kim
Acylase (AC) was immobilized and stabilized on carboxylated polyaniline nanofibers (cPANFs) for the development of antifouling nanobiocatalysts with high enzyme loading and stability. AC was immobilized via three different approaches: covalent attachment (CA), enzyme coating (EC), and magnetically separable enzyme precipitate coating (Mag-EPC). The enzyme activity per unit weight of cPANFs with Mag-EPC was 75 and 300 times higher than that of those with CA and EC, respectively, representing improved enzyme loading in the form of Mag-EPC...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28407206/pre-ejection-period-reactivity-to-reward-is-associated-with-anhedonic-symptoms-of-depression-among-adolescents
#20
Joshua J Ahles, Amy H Mezulis, Sheila E Crowell
Pre-ejection period (PEP) reactivity to reward has been posited as a specific index of behavioral approach and incentive motivation, suggesting it might be uniquely associated with the affective and motivational deficits of anhedonia. This study evaluated PEP reactivity to a reward task as a predictor of depressive symptoms among adolescents, examining global depressive symptoms as well as specific anhedonic and nonanhedonic symptoms clusters. Participants included 76 adolescents, ages 11-15 years (52% female)...
April 13, 2017: Developmental Psychobiology
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