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https://www.readbyqxmd.com/read/28323149/the-effect-of-tobramycin-incorporated-with-bismuth-ethanedithiol-loaded-on-niosomes-on-the-quorum-sensing-and-biofilm-formation-of-pseudomonas-aeruginosa
#1
Faeze Mahdiun, Shahla Mansouri, Payam Khazaeli, Rasoul Mirzaei
Pseudomonas aeruginosa is an opportunistic pathogen, enable of causing infections especially in immunocompromised patients. Recently many isolates developed multiple drug resistance, resulting in treatment failure in serious infections. In this study, the effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm production by P. aeruginosa was evaluated. Thin layer hydration method with cholesterol (30%), Span 40 and Tween 40 were used to make niosomes...
March 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28303956/inhibitory-role-of-acyl-homoserine-lactones-in-hemolytic-activity-and-viability-of-streptococcus-pyogenes-m6-s165
#2
Sunil D Saroj, Linda Holmer, Júlia M Berengueras, Ann-Beth Jonsson
Streptococcus pyogenes an adapted human pathogen asymptomatically colonizes the nasopharynx, among other polymicrobial communities. However, information on the events leading to the colonization and expression of virulence markers subject to interspecies and host-bacteria interactions are limited. The interference of acyl homoserine lactones (AHLs) with the hemolytic activity and viability of S. pyogenes M6 S165 was examined. AHLs, with fatty acid side chains ≥12 carbon atoms, inhibited hemolytic activity by downregulating the expression of the sag operon involved in the production of streptolysin S...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297640/signal-destruction-tunes-the-zone-of-activation-in-spatially-distributed-signaling-networks
#3
Kalinga Pavan Silva, Prithiviraj Chellamuthu, James Q Boedicker
Diverse microbial communities coordinate group behaviors through signal exchange, such as the exchange of acyl-homoserine lactones (AHLs) by Gram-negative bacteria. Cellular communication is prone to interference by neighboring microbes. One mechanism of interference is signal destruction through the production of an enzyme that cleaves the signaling molecule. Here we examine the ability of one such interference enzyme, AiiA, to modulate signal propagation in a spatially distributed system of bacteria. We have developed an experimental assay to measure signal transduction and implement a theoretical model of signaling dynamics to predict how the system responds to interference...
March 14, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28287619/effects-of-cdh23-single-nucleotide-substitutions-on-age-related-hearing-loss-in-c57bl-6-and-129s1-sv-mice-and-comparisons-with-congenic-strains
#4
Kenneth R Johnson, Cong Tian, Leona H Gagnon, Haiyan Jiang, Dalian Ding, Richard Salvi
A single nucleotide variant (SNV) of the cadherin 23 gene (Cdh23(c.753A)), common to many inbred mouse strains, accelerates age-related hearing loss (AHL) and can worsen auditory phenotypes of other mutations. We used homologous recombination in C57BL/6 NJ (B6N) and 129S1/SvImJ (129S1) embryonic stem cells to engineer mouse strains with reciprocal single base pair substitutions (B6-Cdh23(c.753A>G) and 129S1-Cdh23(c.753G>A)). We compared ABR thresholds and cochlear pathologies of these SNV mice with those of congenic (B6...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28281272/quorum-sensing-of-microalgae-associated-marine-ponticoccus-sp-pd-2-and-its-algicidal-function-regulation
#5
Wendan Chi, Li Zheng, Changfei He, Bin Han, Minggang Zheng, Wei Gao, Chengjun Sun, Gefei Zhou, Xiangxing Gao
Quorum sensing (QS) systems play important roles in regulating many physiological functions of microorganisms, such as biofilm formation, bioluminescence, and antibiotic production. One marine algicidal bacterium, Ponticoccus sp. PD-2, was isolated from the microalga Prorocentrum donghaiense, and its N-acyl-homoserine lactone (AHL)-mediated QS system was verified. In this study, we analyzed the AHLs profile of strain PD-2. Two AHLs, 3-oxo-C8-HSL and 3-oxo-C10-HSL, were detected using a biosensor overlay assay and GC-MS methods...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28275834/%C3%AE-blocker-after-severe-traumatic-brain-injury-is-associated-with-better-long-term-functional-outcome-a-matched-case-control-study
#6
R Ahl, E P Thelin, G Sjölin, B-M Bellander, L Riddez, P Talving, S Mohseni
PURPOSE: Severe traumatic brain injury (TBI) is the predominant cause of death and disability following trauma. Several studies have observed improved survival in TBI patients exposed to β-blockers, however, the effect on functional outcome is poorly documented. METHODS: Adult patients with severe TBI (head AIS ≥ 3) were identified from a prospectively collected TBI database over a 5-year period. Patients with neurosurgical ICU length of stay <48 h and those dying within 48 h of admission were excluded...
March 8, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28275548/novel-quorum-quenching-enzymes-identified-from-draft-genome-of-roseomonas-sp-tas13
#7
Eri Nasuno, Tomohiro Suzuki, Ryoko Suzuki, Chigusa Okano, Takeshi Kurokura, Ken-Ichi Iimura, Norihiro Kato
Roseomonas sp. strain TAS13 isolated from an activated sludge sample degrades N-acylhomoserine lactones (AHLs) that are widely utilized as a signal in bacterial quorum sensing systems. The draft genome of Roseomonas sp. TAS13 contains 816 contigs (total 5,078,941 bp) which carries 4760 protein-coding genes and 52 tRNA genes (DDBJ/EMBL/GenBank accession numbers BDLP01000001 through BDLP01000816).
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28265730/does-beta-blockade-reduce-the-risk-of-depression-in-patients-with-isolated-severe-extracranial-injuries
#8
Rebecka Ahl, Galinos Barmparas, Louis Riddez, Eric J Ley, Göran Wallin, Olle Ljungqvist, Shahin Mohseni
BACKGROUND: Approximately half of trauma patients develop post-traumatic depression. It is suggested that beta-blockade impairs trauma memory recollection, reducing depressive symptoms. This study investigates the effect of early beta-blockade on depression following severe traumatic injuries in patients without significant brain injury. METHODS: Patients were identified by retrospectively reviewing the trauma registry at an urban university hospital between 2007 and 2011...
March 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28244432/simulating-and-optimizing-compound-refractive-lens-based-x-ray-microscopes
#9
Hugh Simons, Sonja Rosenlund Ahl, Henning Friis Poulsen, Carsten Detlefs
A comprehensive optical description of compound refractive lenses (CRLs) in condensing and full-field X-ray microscopy applications is presented. The formalism extends ray-transfer matrix analysis by accounting for X-ray attenuation by the lens material. Closed analytical expressions for critical imaging parameters such as numerical aperture, spatial acceptance (vignetting), chromatic aberration and focal length are provided for both thin- and thick-lens imaging geometries. These expressions show that the numerical aperture will be maximized and chromatic aberration will be minimized at the thick-lens limit...
March 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28239068/complete-genome-sequence-of-pseudomonas-chlororaphis-subsp-aurantiaca-reveals-a-triplicate-quorum-sensing-mechanism-for-regulation-of-phenazine-production
#10
Tomohiro Morohoshi, Takahito Yamaguchi, Xiaonan Xie, Wen-Zhao Wang, Kasumi Takeuchi, Nobutaka Someya
Pseudomonas chlororaphis subsp. aurantiaca StFRB508 regulates phenazine production through N-acyl-l-homoserine lactone (AHL)-mediated quorum sensing. Two sets of AHL-synthase and AHL-receptor genes, phzI/phzR and aurI/aurR, have been identified from the incomplete draft genome of StFRB508. In the present study, the complete genome of StFRB508, comprising a single chromosome of 6,997,933 bp, was sequenced. The complete genome sequence revealed the presence of a third quorum-sensing gene set, designated as csaI/csaR...
February 25, 2017: Microbes and Environments
https://www.readbyqxmd.com/read/28225085/aidp-a-novel-n-acyl-homoserine-lactonase-gene-from-antarctic-planococcus-sp
#11
Wah Seng See-Too, Robson Ee, Yan-Lue Lim, Peter Convey, David A Pearce, Wai-Fong Yin, Kok-Gan Chan
Planococcus is a Gram-positive halotolerant bacterial genus in the phylum Firmicutes, commonly found in various habitats in Antarctica. Quorum quenching (QQ) is the disruption of bacterial cell-to-cell communication (known as quorum sensing), which has previously been described in mesophilic bacteria. This study demonstrated the QQ activity of a psychrotolerant strain, Planococcus versutus strain L10.15(T), isolated from a soil sample obtained near an elephant seal wallow in Antarctica. Whole genome analysis of this bacterial strain revealed the presence of an N-acyl homoserine lactonase, an enzyme that hydrolyzes the ester bond of the homoserine lactone of N-acyl homoserine lactone (AHLs)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28213548/effects-of-gelling-agent-and-extracellular-signaling-molecules-on-the-culturability-of-marine-bacteria
#12
Anita Mac Rygaard, Mariane Schmidt Thøgersen, Kristian Fog Nielsen, Lone Gram, Mikkel Bentzon-Tilia
Only 1 % of marine bacteria are currently culturable using standard laboratory procedures and this is a major obstacle for our understanding of the biology of marine microorganisms and for the discovery of novel microbial natural products. Therefore, the purpose of the present study was to investigate if improved cultivation conditions, including the use of an alternative gelling agent, and supplementation with signaling molecules, could improve the culturability of bacteria from seawater. Substituting agar with gellan gum improved viable counts 3 - 40-fold, depending on medium composition and incubation conditions, with a maximum of 6...
February 17, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28197135/cloning-and-characterization-of-the-autoinducer-synthase-gene-from-lipid-degrading-bacterium-cedecea-neteri
#13
Kian-Hin Tan, Kah-Yan How, Jia-Yi Tan, Wai-Fong Yin, Kok-Gan Chan
The process of intercellular communication among bacteria, termed quorum sensing (QS), is mediated by small diffusible molecules known as the autoinducers. QS allows the population to react to the change of cell density in unison, in processes such as biofilm formation, plasmid conjugation, virulence, motility and root nodulation. In Gram-negative proteobacteria, N-acyl homoserine lactone (AHL) is the common "language" to coordinate gene expression. This signaling molecule is usually synthesized by LuxI-type proteins...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28164039/quorum-sensing-n-acyl-homoserine-lactones-sdia-suppresses-escherichia-coli-pseudomonas-aeruginosa-conjugation-through-inhibiting-trai-expression
#14
Yang Lu, Jianming Zeng, Binning Wu, Shunmei E, Lina Wang, Renxin Cai, Ni Zhang, Youqiang Li, Xianzhang Huang, Bin Huang, Cha Chen
Conjugation is a key mechanism for horizontal gene transfer and plays an important role in bacterial evolution, especially with respect to antibiotic resistance. However, little is known about the role of donor and recipient cells in regulation of conjugation. Here, using an Escherichia coli (SM10λπ)-Pseudomonas aeruginosa (PAO1) conjugation model, we demonstrated that deficiency of lasI/rhlI, genes associated with generation of the quorum sensing signals N-acyl homoserine lactones (AHLs) in PAO1, or deletion of the AHLs receptor SdiA in the donor SM10λπ both facilitated conjugation...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28149306/characterization-of-a-genomic-region-under-selection-in-cultivated-carrot-daucus-carota-subsp-sativus-reveals-a-candidate-domestication-gene
#15
Alicja Macko-Podgórni, Gabriela Machaj, Katarzyna Stelmach, Douglas Senalik, Ewa Grzebelus, Massimo Iorizzo, Philipp W Simon, Dariusz Grzebelus
Carrot is one of the most important vegetables worldwide, owing to its capability to develop fleshy, highly nutritious storage roots. It was domesticated ca. 1,100 years ago in Central Asia. No systematic knowledge about the molecular mechanisms involved in the domestication syndrome in carrot are available, however, the ability to form a storage root is undoubtedly the essential transition from the wild Daucus carota to the cultivated carrot. Here, we expand on the results of a previous study which identified a polymorphism showing a significant signature for selection upon domestication...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28148985/multiplicity-of-quorum-quenching-enzymes-a-potential-mechanism-to-limit-quorum-sensing-bacterial-population
#16
Shikha Koul, Vipin Chandra Kalia
Bacteria express certain of their characteristics especially, pathogenicity factors at high cell densities. The process is termed as quorum sensing (QS). QS operates via signal molecules such as acylhomoserine lactones (AHLs). Other bacteria inhibit QS through the inactivation of AHL signals by producing enzymes like AHL-lactonases and -acylases. Comparative genomic analysis has revealed the multiplicity of genes for AHL lactonases (up to 12 copies per genome) among Bacillus spp. and that of AHL-acylases (up to 5 copies per genome) among Pseudomonas spp...
March 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/28141492/rnase-e-and-rnase-j-are-needed-for-s-adenosylmethionine-homeostasis-in-sinorhizobium-meliloti
#17
Kathrin Baumgardt, Hendrik Melior, Ramakanth Madhugiri, Sebastian Thalmann, Adam Schikora, Matthew McIntosh, Anke Becker, Elena Evguenieva-Hackenberg
The ribonucleases (RNases) E and J play major roles in Escherichia coli and Bacillus subtilis, respectively, and co-exist in Sinorhizobium meliloti. We analyzed S. meliloti 2011 mutants with mini-Tn5 insertions in the corresponding genes rne and rnj and found many overlapping effects. We observed similar changes in mRNA levels including lower mRNA levels of the motility and chemotaxis related genes flaA, flgB, and cheR and higher levels of ndvA (important for glucan export). The acyl-homoserine lactone (AHL) levels were also higher during exponential growth in both RNase mutants, despite no increase in the expression of the sinI AHL synthase gene...
January 28, 2017: Microbiology
https://www.readbyqxmd.com/read/28137764/elevated-temperature-enhances-short-to-medium-chain-acyl-homoserine-lactone-production-by-black-band-disease-associated-vibrios
#18
Chinmayee D Bhedi, Carson W Prevatte, Maggie S Lookadoo, Patricia A Waikel, Patrick M Gillevet, Masoumeh Sikaroodi, Shawn R Campagna, Laurie L Richardson
Black band disease (BBD) of corals is a horizontally migrating, pathogenic, polymicrobial mat community which is active above a temperature threshold of 27.5°C on the reef. Bacterial isolates from BBD, the surface mucopolysaccharide layer (SML) of healthy corals, and SML of healthy areas of BBD infected corals were tested for production of short to medium chain acyl homoserine lactones (AHLs) using the Chromobacterium violaceum CV026 reporter strain. Of 110 bacterial isolates tested, 19 produced AHLs and 15 of these were from BBD...
January 29, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28133926/n-acylhomoserine-lactone-regulation-of-genes-mediating-motility-and-pathogenicity-in-pseudomonas-syringae-pathovar-tabaci-11528
#19
Feifei Cheng, Anzhou Ma, Jinxue Luo, Xuliang Zhuang, Guoqiang Zhuang
Pseudomonas syringae pathovar tabaci 11528 (P. syringae 11528) is a phytopathogen that causes wild-fire disease in soybean and tobacco plants. It utilizes a cell density-dependent regulation system known as quorum sensing (QS). In its QS system, the psyI is responsible for the biosynthesis of N-acylhomoserine lactones (AHLs). By comparing the transcripts from P. syringae 11528 wild-type strain with those of the ΔpsyI mutant using RNA sequencing (RNA-seq) technology, 1118 AHL-regulated genes were identified in the transition from exponential to stationary growth phase...
January 29, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28129983/identification-and-characterization-of-a-novel-n-acyl-homoserine-lactonase-gene-in-sphingomonas-ursincola-isolated-from-industrial-cooling-water-systems
#20
Tomohiro Morohoshi, Niina Sato, Taro Iizumi, Airi Tanaka, Tsukasa Ikeda
Biofilm formation by bacteria is one of the main causes of fouling in industrial cooling water systems. In many gram-negative bacteria, biofilm formation is regulated by N-acyl-homoserine lactone (AHL)-mediated quorum sensing. In this study, we isolated three AHL-degrading bacteria from cooling water systems and identified them as Sphingomonas ursincola. The draft genome sequence of S. ursincola A1 revealed the presence of an AHL-degrading gene homolog, designated qsdS. The qsdS region was also amplified by PCR from the genomes of the other two S...
January 24, 2017: Journal of Bioscience and Bioengineering
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