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https://www.readbyqxmd.com/read/28711170/early-selenium-treatment-for-traumatic-brain-injury-does-it-improve-survival-and-functional-outcome
#1
Hosseinali Khalili, Rebecka Ahl, Yang Cao, Shahram Paydar, Gabriel Sjölin, Amin Niakan, Gholamreza Dabiri, Shahin Mohseni
BACKGROUND: Traumatic brain injury (TBI) is a major cause of death and debility following trauma. The initial brain tissue insult is worsened by secondary reactive responses including oxidative stress reactions, inflammatory changes and subsequent permanent neurologic deficits. Effective agents to improve functional outcome and survival following TBI are scarce. Selenium is an antioxidant which has shown to reduce oxidative stress. This study examines the effect of intravenous selenium (Selenase(®)) treatment in patients with severe TBI on functional outcome and survival in a prospective study design...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28706380/importance-of-anterior-humeral-line-for-successful-anatomical-reduction-in-the-surgical-treatment-of-pediatric-supracondylar-humeral-fractures
#2
Takamasa Shimizu, Atsushi Yoshida, Shohei Omokawa, Tadanobu Onishi, Tsutomu Kira, Shigeru Santo, Hideo Hasewgawa, Kenji Kawamura, Yasuhito Tanaka
Anterior humeral line (AHL) and tilting angle (TA) are used for the assessment of pediatric elbow sagittal plane alignment in surgical treatment of pediatric supracondylar humeral fracture. However, few studies exist that compare the reliabilities between these parameters. The purpose of this study is to determine whether measurements of radiographic parameters are reliable and useful for achieving anatomical reduction. In the current study, we demonstrated that the identifying the AHL location involves a simple and reliable measurement compared with TA...
September 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28702008/hypersensitive-response-of-plasmid-encoded-ahl-synthase-gene-to-lifestyle-and-nutrient-by-ensifer-adhaerens-x097
#3
Yanhua Zeng, Yanli Wang, Zhiliang Yu, Yili Huang
It is known that some bacteria, especially members of the family Rhizobiaceae, have multiple N-acyl homoserine lactones (AHL) synthase genes and produce multiple AHL signals. However, how bacteria selectively utilize these multiple genes and signals to cope with changing environments is poorly understood. Ensifer adhaerens is an important microorganism in terms of biotechnology, ecology and evolutionary. In this study, we investigated the AHL-based QS system of E. adhaerens X097 and its response to different lifestyles or nutrients...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28701854/is-linguistic-injustice-a-myth-a-response-to-hyland-2016
#4
Stephen Politzer-Ahles, Jeffrey J Holliday, Teresa Girolamo, Maria Spychalska, Kelly Harper Berkson
No abstract text is available yet for this article.
December 2016: J Second Lang Writ
https://www.readbyqxmd.com/read/28697551/n-acyl-homoserine-lactone-dynamics-during-biofilm-formation-of-a-1-2-4-trichlorobenzene-mineralizing-community-on-clay
#5
Hongjie Sheng, Mourad Harir, Lisa A Boughner, Xin Jiang, Philippe Schmitt-Kopplin, Reiner Schroll, Fang Wang
In Gram-negative bacteria, quorum sensing systems are based on the N-acyl-homoserine lactone (AHL) molecule. The objective of this study was to investigate the role of quorum sensing systems during biofilm formation by a microbial community while degrading the pollutant. Our model system included 1,2,4-trichlorobenzene (1,2,4-TCB) and its mineralizing Gram-negative bacterial community to investigate the relationships between AHL dynamics, cell growth and pollutant degradation. Biomineralization of 1,2,4-TCB was monitored for both the planktonic bacterial community with and without sterile clay particles in liquid cultures...
July 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28695853/crystal-structure-of-the-n-terminal-domain-of-vqsr-from-pseudomonas-aeruginosa-at-2-1%C3%A2-%C3%A3-resolution
#6
Qing He, Kang Wang, Tiantian Su, Feng Wang, Lichuan Gu, Sujuan Xu
VqsR is a quorum-sensing (QS) transcriptional regulator which controls QS systems (las, rhl and pqs) by directly downregulating the expression of qscR in Pseudomonas aeruginosa. As a member of the LuxR family of proteins, VqsR shares the common motif of a helix-turn-helix (HTH)-type DNA-binding domain at the C-terminus, while the function of its N-terminal domain remains obscure. Here, the crystal structure of the N-terminal domain of VqsR (VqsR-N; residues 1-193) was determined at a resolution of 2.1 Å...
July 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28690598/large-diversity-and-original-structures-of-acyl-homoserine-lactones-in-strain-mola-401-a-marine-rhodobacteraceae-bacterium
#7
Margot Doberva, Didier Stien, Jonathan Sorres, Nathalie Hue, Sophie Sanchez-Ferandin, Véronique Eparvier, Yoan Ferandin, Philippe Lebaron, Raphaël Lami
Quorum sensing (QS) is a density-dependent mechanism allowing bacteria to synchronize their physiological activities, mediated by a wide range of signaling molecules including N-acyl-homoserine lactones (AHLs). Production of AHL has been identified in various marine strains of Proteobacteria. However, the chemical diversity of these molecules still needs to be further explored. In this study, we examined the diversity of AHLs produced by strain MOLA 401, a marine Alphaproteobacterium that belongs to the ubiquitous Rhodobacteraceae family...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28688010/quorum-sensing-molecules-production-by-nosocomial-and-soil-isolates-acinetobacter-baumannii
#8
Demet Erdönmez, Abbas Yousefi Rad, Nilüfer Aksöz
Acinetobacter species remain alive in hospitals on various surfaces, both dry and moist, forming an important source of hospital infections. These bacteria are naturally resistant to many antibiotic classes. Although the role of the quorum sensing system in regulating the virulence factors of Acinetobacter species has not been fully elucidated, it has been reported that they play a role in bacterial biofilm formation. The biofilm formation helps them to survive under unfavorable growth conditions and antimicrobial treatments...
July 7, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28687817/etiologic-and-audiologic-characteristics-of-patients-with-pediatric-onset-unilateral-and-asymmetric-sensorineural-hearing-loss
#9
Pei-Hsuan Lin, Chuan-Jen Hsu, Yi-Hsin Lin, Yin-Hung Lin, Hui-Yu Lee, Chen-Chi Wu, Tien-Chen Liu
Importance: Pediatric-onset unilateral and asymmetric sensorineural hearing loss (SNHL) is a common condition, but in most patients, the cause remains unclear; thus, determination of the hearing outlook is difficult. Objective: To analyze the etiologic and audiologic characteristics of pediatric-onset unilateral and asymmetric SNHL. Design, Setting, and Participants: In this retrospective cohort study performed from January 1, 2008, through December 31, 2016, patients at a tertiary referral center who were diagnosed with pediatric-onset unilateral or asymmetric SNHL were divided into 3 groups according to their hearing levels: unilateral hearing loss with scaled-out levels (UHL-SO), unilateral hearing loss with residual hearing (UHL-RH), and asymmetric hearing loss (AHL)...
July 6, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28685594/disruption-of-the-quorum-sensing-regulated-pathogenic-traits-of-the-biofilm-forming-fish-pathogen-aeromonas-hydrophila-by-tannic-acid-a-potent-quorum-quencher
#10
Bhakti Patel, Supriya Kumari, Rajanya Banerjee, Mrinal Samanta, Surajit Das
The quorum sensing (QS) phenomenon regulates a myriad of pathogenic traits in the biofilm forming fish pathogen, Aeromonas hydrophila. Blocking the QS mechanism of A. hydrophila is a novel strategy to prevent disease in fish. This study evaluated the effect of tannic acid, a QS inhibitor, on A. hydrophila-associated QS regulated phenomena. A streaking assay with Chromobacterium violaceum (CVO26) reported the presence of N-acyl homoserine lactone (AHL) in A. hydrophila, which was confirmed by HPLC and GC-MS analysis...
July 7, 2017: Biofouling
https://www.readbyqxmd.com/read/28684366/impact-of-species-delimitation-and-sampling-on-niche-models-and-phylogeographical-inference-a-case-study-of-the-east-african-reed-frog-hyperolius-substriatus-ahl-1931
#11
Gabriela B Bittencourt-Silva, Lucinda P Lawson, Krystal A Tolley, Daniel M Portik, Christopher D Barratt, Peter Nagel, Simon P Loader
Ecological niche models (ENMs) have been used in a wide range of ecological and evolutionary studies. In biogeographic studies these models have, among other things, helped in the discovery of new allopatric populations, and even new species. However, small sample sizes and questionable taxonomic delimitation can challenge models, often decreasing their accuracy. Herein we examine the sensitivity of ENMs to the addition of new, geographically isolated populations, and the impact of applying different taxonomic delimitations...
July 3, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28676791/interplay-between-4-hydroxy-3-methyl-2-alkylquinoline-and-n-acyl-homoserine-lactone-signaling-in-a-burkholderia-cepacia-complex-clinical-strain
#12
Annelise Chapalain, Marie-Christine Groleau, Servane Le Guillouzer, Aurélie Miomandre, Ludovic Vial, Sylvain Milot, Eric Déziel
Species from the Burkholderia cepacia complex (Bcc) share a canonical LuxI/LuxR quorum sensing (QS) regulation system named CepI/CepR, which mainly relies on the acyl-homoserine lactone (AHL), octanoyl-homoserine lactone (C8-HSL) as signaling molecule. Burkholderia ambifaria is one of the least virulent Bcc species, more often isolated from rhizospheres where it exerts a plant growth-promoting activity. However, clinical strains of B. ambifaria display distinct features, such as phase variation and higher virulence properties...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28674525/deciphering-physiological-functions-of-ahl-quorum-quenching-acylases
#13
REVIEW
Putri D Utari, Jan Vogel, Wim J Quax
N-Acylhomoserine lactone (AHL)-acylase (also known as amidase or amidohydrolase) is a class of enzyme that belongs to the Ntn-hydrolase superfamily. As the name implies, AHL-acylases are capable of hydrolysing AHLs, the most studied signaling molecules for quorum sensing in Gram-negative bacteria. Enzymatic degradation of AHLs can be beneficial in attenuating bacterial virulence, which can be exploited as a novel approach to fight infection of human pathogens, phytopathogens or aquaculture-related contaminations...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28670747/rod-like-tetracene-derivatives
#14
Michael Roth, Marcus Ahles, Christian Gawrisch, Thorsten Schwalm, Roland Schmechel, Christian Melzer, Heinz von Seggern, Matthias Rehahn
An efficient and versatile synthetic access to rod-like tetracene derivatives has been developed using Diels-Alder cycloaddition, halogenation, halogen-metal exchange, and transition-metal mediated coupling reactions. Here we review the synthesis of three of the resulting materials, i.e., 2-(tetracen-2-yl) tetracene (DT), 1,4-bis(2-tetracenyl)benzene (TPT), and 2,5-bis(2-tetracenyl)-thiophene (TTT), and present their structural, electrical and charge-transport properties. Good crystallization behaviour on SiO2 substrates, a narrowing of the bandgap by 0...
July 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28670299/detection-of-diverse-n-acyl-homoserine-lactones-in-vibrio-alginolyticus-and-regulation-of-biofilm-formation-by-n-3-oxodecanoyl-homoserine-lactone-in-vitro
#15
Jianfei Liu, Kaifei Fu, Yuxiao Wang, Chenglin Wu, Fei Li, Lei Shi, Yinlin Ge, Lijun Zhou
Quorum sensing (QS) is a cell-to-cell communication system based on the exchange of small intercellular signal molecules, such as N-Acyl homoserine lactones (AHLs), which act as cell-density mediators of QS gene expression, and are highly variable both in types and amounts in most Gram-negative Proteobacteria. Understanding the regulation of AHLs may contribute to the elucidation of cell density-dependent phenomena, such as biofilm formation. Vibrio alginolyticus is among the most frequently observed marine opportunistic Vibrio pathogens...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28662345/comprehension-of-presuppositions-in-school-age-cantonese-speaking-children-with-and-without-autism-spectrum-disorders
#16
Candice Chi-Hang Cheung, Stephen Politzer-Ahles, Heeju Hwang, Ronald Lung Yat Chui, Man Tak Leung, Tempo Po Yi Tang
While an enormous amount of research has been done on the deficient conversation skills in individuals with autism spectrum disorders (ASD), little is known about their performance on presuppositions, a domain of knowledge that is crucial for successful communication. This study investigated the comprehension of four types of presupposition, namely existential, factive, lexical and structural presuppositions, in school-age Cantonese-speaking children with and without ASD. A group of children with ASD (n = 21), mean age 8...
June 29, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28651911/conformational-studies-of-gram-negative-bacterial-quorum-sensing-3-oxo-n-acyl-homoserine-lactone-molecules
#17
Darren Crowe, Alan Nicholson, Adrienne Fleming, Ed Carey, Goar Sánchez-Sanz, Fintan Kelleher
In their (1)H NMR spectra in CDCl3 3-oxo-N-acyl homoserine lactones (OHLs) show significant downfield chemical shifts of the amide NH proton when compared to the parent N-acyl homoserine lactones (AHLs). NMR spectroscopic and DFT calculation studies have shown that this is most likely due to the presence of a stabilising intramolecular H-bond from the NH to the 3-oxo group. The (1)H NMR spectra also show evidence for the enol tautomers and that the amount of enol present for a range of OHLs is 4.1-4.5% in CDCl3 and 6...
June 8, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28633201/rapid-start-up-of-denitrifying-granular-sludge-by-dosing-with-semi-starvation-fluctuation-c-n-ratio-strategy
#18
Wenyu Niu, Jianbo Guo, Jing Lian, Yuanyuan Song, Caicai Lu, Haibo Li, Yi Han, Pengna Yin
This study cultivated denitrifying granular sludge in three UASB reactors by the semi-starvation fluctuation C/N ratio strategy (reactor 1 (R1): constant C/N ratio; R2: regular fluctuation C/N ratio; and R3: semi-starvation fluctuation C/N ratio (SSF)). Microbial aggregates appeared in R1, R2 and R3 on days 28, 14 and 6, respectively. Compared with the results in R1 and R2, the guanosine tetraphosphate (ppGpp) concentration was highest, the acyl homoserine lactones (AHLs) concentration quickly reached a certain threshold, and more protein (PN) of extracellular polymeric substances (EPS) secretion resulted in the rapid formation of denitrifying granular sludge in R3...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28624619/quorum-sensing-signals-enhance-the-electrochemical-activity-and-energy-recovery-of-mixed-culture-electroactive-biofilms
#19
Shanshan Chen, Xianyue Jing, Jiahuan Tang, Yanlun Fang, Shungui Zhou
The impacts of exogenous or endogenous quorum sensing (QS) signaling molecules on mixed-culture electroactive biofilms (EABs), especially extracellular polymeric substances (EPS) and exoelectrogens using direct electron transfer mechanism inside EABs are poorly understood. This research focuses on the influence of acylhomoserine lactones (AHLs), the most common QS signaling molecules for gram negative bacteria, on mixed-culture EABs. Results indicated that both exogenous and endogenous AHLs played the role as regulators to improve the electrochemical activities of EABs...
June 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28614901/x-ray-crystal-structures-of-the-pheromone-binding-domains-of-two-quorum-hindered-transcription-factors-yenr-of-yersinia-enterocolitica-and-cepr2-of-burkholderia-cenocepacia
#20
Youngchang Kim, Gekleng Chhor, Ching-Sung Tsai, Gabriel Fox, Chia-Sui Chen, Nathan J Winans, Robert Jedrzejczak, Andrzej Joachimiak, Stephen C Winans
The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and some of them require AHLs for folding and stability, and for protease-resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. One such protein is YenR of Yersinia enterocolitica, which is antagonized by N-3-oxohexanoyl-l-homoserine lactone (OHHL)...
June 14, 2017: Proteins
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