Atika Malique, Shengxiang Sun, Kanta Chandwe, Beatrice Amadi, Talin Haritunians, Umang Jain, Brian D Muegge, Jennifer Frein, Yo Sasaki, Amanda Foster, Chad E Storer, Emebet Mengesha, Justin Kern, Dermot P B McGovern, Richard D Head, Paul Kelly, Ta-Chiang Liu
Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss of the small intestinal Paneth and goblet cells that are critical for innate immunity, reduced villous height, increased bile acids, and dysregulated nicotinamide adenine dinucleotide (NAD+ ) synthesis signaling as potential mechanisms underlying EED and which also correlated with diminished length-for-age z score...
January 3, 2024: Science Translational Medicine