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Caustic esophagitis

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https://www.readbyqxmd.com/read/29892928/halofuginone-improves-caustic-induced-oxidative-injury-of-esophagus-in-rats
#1
Kıvılcım Karadeniz Cerit, Berna Karakoyun, Elif Bahadır, Meral Yüksel, Nurdan Bülbül, Feriha Ercan, E Tolga Dağlı, Berrak Ç Yeğen
BACKGROUND: The aim of this study is to evaluate the anti-inflammatory and anti-fibrotic effects of halofuginone in caustic esophageal burn injury in rats. MATERIALS AND METHODS: Corrosive esophageal injury (CEI) was produced in male Wistar albino rats by instilling NaOH solution (1 ml, 37.5%) into the distal esophagus. Rats were decapitated on the 3rd day (early group) or 28th day (late group), and treated daily with either saline or halofuginone (100 µg/kg/day; i...
April 2018: Esophagus: Official Journal of the Japan Esophageal Society
https://www.readbyqxmd.com/read/29890517/endoscopic-mucosal-autograft-for-treating-esophageal-caustic-strictures-preliminary-human-experience
#2
Kexin He, Lili Zhao, Shoushan Bu, Li Liu, Xiang Wang, Min Wang, Zhining Fan
 Esophageal caustic stricture is a stubborn disease and postoperative restenosis limits the clinical efficacy of endoscopic dilation. Autologous mucosal grafts have been successfully applied in the treatment of urethral stricture and in the prevention of stricture after extensive mucosal resection. We aimed to use mucosal autografting performed endoscopically to treat refractory esophageal stricture. METHODS : Three patients with intractable corrosive esophageal stricture were treated endoscopically by combining dilation with autologous mucosal transplantation...
June 11, 2018: Endoscopy
https://www.readbyqxmd.com/read/29889306/ph-neutralizing-esophageal-irrigations-as-a-novel-mitigation-strategy-for-button-battery-injury
#3
Rachel R Anfang, Kris R Jatana, Rebecca L Linn, Keith Rhoades, Jared Fry, Ian N Jacobs
OBJECTIVES/HYPOTHESIS: Ingestion of button batteries (BB) can rapidly lead to caustic esophageal injury in infants and children, resulting in significant morbidity and mortality. To identify novel mitigation strategies, we tested common weakly acidic household beverages, viscous liquids, and Carafate® for their ability to act as protective esophageal irrigations until endoscopic removal of the BB. STUDY DESIGN: Cadaveric and live animal model. METHODS: Apple juice, orange juice, Gatorade®, POWERADE®, pure honey, pure maple syrup, and Carafate® were screened using a 3 V lithium (3 V-CR2032) BB on cadaveric porcine esophagus...
June 11, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29869478/-about-a-cresol-intoxication
#4
S Fatihi, P Mols
Cresols are phenol derivatives commonly used as surface disinfectants. Ingestion may cause local mucocutaneous damage and extensive systemic toxicity : central nervous, cardiovascular, hematological, hepatic, renal and pulmonary. We describe the case of a 33-year-old woman who swallowed, without suicidal intent, 50 to 70 cm3 of a 50% cresol solution. Coma occurred within 5 minutes of ingestion, she presented a bradypnea with desaturation, and the SMUR team performed on-site an orotracheal intubation. On arrival at the hospital, the patient had typical caustic lesions around her mouth...
May 30, 2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29869087/prospective-study-of-the-effect-of-topical-application-of-mitomycin-c-in-refractory-pediatric-caustic-esophageal-strictures
#5
Carolyne Morcos Ghobrial, A E Eskander
BACKGROUND: Esophageal strictures resulting from caustic ingestion in children are usually difficult to be managed, and surgical replacement is usually required for cases refractory to frequent dilatation sessions. Topical Mitomycin C (MMC) has been recently used in the management of resistant strictures. We evaluated the efficacy of MMC application in treatment of long refractory caustic esophageal strictures. METHODS: This prospective study included 120 patients of both sexes with refractory caustic long esophageal strictures (> 3 cm in length)...
June 4, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29788901/recurrent-esophageal-stricture-from-previous-caustic-ingestion-treated-with-40-year-self-dilation-case-report-and-review-of-literature
#6
C Gambardella, A Allaria, G Siciliano, C Mauriello, R Patrone, N Avenia, A Polistena, A Sanguinetti, S Napolitano, G Conzo
BACKGROUND: Corrosive esophageal strictures are common. The severity of the strictures depends on type, quantity, duration of contact and concentration of the caustic substance ingested. Endoscopic balloon dilation and endoscopic bougienage are a cornerstone in the management of the benign esophageal strictures and are the most widely used treatments, but are expensive and invasive procedures. CASE PRESENTATION: We report the case of an 82-year-old patient with a corrosive esophageal stricture treated for over 40 years by means of home self-bougienage...
May 22, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29697549/endoscopic-electrocautery-incisional-therapy-as-a-treatment-for-refractory-benign-pediatric-esophageal-strictures
#7
Michael A Manfredi, Susannah J Clark, Shawn Medford, Steven J Staffa, Peter Ngo, Thomas E Hamilton, C Jason Smithers, Russell W Jennings
BACKGROUND AND AIM: Refractory esophageal strictures are rare conditions in pediatrics, and are often due to anastomotic, congenital, or caustic strictures. Traditional treatment options include serial dilation and surgical stricture resection; endoscopic intralesional steroid injections, mitomycin C, and externally removable stents combined with dilation have had variable success rates. Although not as widely used, endoscopic electrocautery incisional therapy (EIT) has been reported as an alternative treatment for refractory strictures in a small number of adult series...
April 23, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29533267/emergency-computed-tomography-predicts-caustic-esophageal-stricture-formation
#8
Matthieu Bruzzi, Mircea Chirica, Matthieu Resche-Rigon, Helene Corte, Thibault Voron, Emile Sarfati, Anne-Marie Zagdanski, Pierre Cattan
BACKGROUND: Endoscopy is the best predictor of stricture formation after caustic ingestion. OBJECTIVE: Our aim was to compare the accuracy of emergency computed tomography (CT) and endoscopy in predicting risks of esophageal stricture. METHODS: We describe a CT classification of esophageal caustic injuries: Grade I show normal esophagus; Grade IIa display internal enhancement of the esophageal mucosa and enhancement of the outer wall conferring a "target" aspect; Grade IIb present as a fine rim of external esophageal wall enhancement...
March 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29528033/incidence-of-childhood-eosinophilic-esophagitis-in-central-brazil-how-many-are-we-missing
#9
L O Gonçalves, M M Lopes, E R Rezende, G Rs Segundo
BACKGROUND: Few studies have assessed the incidence of eosinophilic esophagitis (EoE) in childhood. The study aim is to determine the incidence of EoE in pediatric patients submitted to upper gastrointestinal endoscopy (UGE), with analysis of epidemiological data regarding sex, age, symptomatology, the frequency of atopy and endoscopic and histological findings. METHODS: A retrospective, observational and analytical study performed with an evaluation of medical records of patients aged 0 to 14 years who underwent to upper gastrointestinal endoscopy in a tertiary hospital from January 2004 to January 2014...
March 12, 2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29509534/esophageal-reconstruction-with-the-stomach-a-functional-dilemma
#10
Dragoş Predescu, Silviu Constantinoiu
Background: A few decades ago, esophageal substitution was mainly dedicated particularly in postcaustic esophageal stenosis; currently, the reconstruction has expanded its palette of indications to other areas of benign esophageal pathology (severe motor disorders, esophageal achalasia with multiple relapses, peptic stenosis, etc.) but has also become a quasi-obligatory final time in the esophagectomy for cancer whenever it is possible. The techniques of esophageal reconstruction using the stomach, regardless of the indication and the chosen technical option, remain a valuable and effective method...
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29349540/self-dilation-for-therapy-resistant-benign-esophageal-strictures-towards-a-systematic-approach
#11
Emo E van Halsema, Chantal A 't Hoen, Patricia S de Koning, Wilda D Rosmolen, Jeanin E van Hooft, Jacques J Bergman
BACKGROUND: Patients with therapy-resistant benign esophageal strictures (TRBES) suffer from chronic dysphagia and generally require repeated endoscopic dilations. For selected patients, esophageal self-dilation may improve patient's autonomy and reduce the number of endoscopic dilations. We evaluated the clinical course and outcomes of patients who started esophageal self-dilation at our institution. METHODS: This study was a retrospective case series of patients with TRBES who started esophageal self-dilation between 2012 and 2016 at the Academic Medical Center Amsterdam...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29286326/role-of-rdw-in-prediction-of-burn-after-caustic-substance-ingestion
#12
Emrah Aydin, Omer Faruk Beser, Soner Sazak, Ensar Duras
A quantifiable, quick, inexpensive and reproducible predictor is needed to decide if caustic substance ingestion results in burn regardless of the symptoms. A multicenter cohort study was conducted to investigate the predictive value of red cell distribution width (RDW) in detecting the esophageal burns. The data of 174 patients were retrospectively analyzed. Eleven patients were excluded due to inability to define the substance ingested. Complete blood count (CBC) was taken at admission, and an esophagogastroduodenoscopy was performed within the first 12-24 h in all patients, regardless of their symptoms...
December 29, 2017: Children
https://www.readbyqxmd.com/read/29216023/corticosteroids-for-preventing-caustic-esophageal-strictures-systematic-review-and-meta-analysis
#13
Raji Katibe, Ibtihal Abdelgadir, Paraic McGrogan, Anthony K Akobeng
OBJECTIVES: Caustic ingestion can have a complicated clinical course. Corticosteroids are widely used but there is uncertainty about its role in preventing esophageal stricture formation following caustic ingestion. This systematic review and meta-analysis assessed the available clinical evidence regarding the efficacy and safety of corticosteroids for preventing esophageal strictures following caustic injury. METHODS: We assessed randomized controlled trials (RCTs) that compared corticosteroids versus no corticosteroids in the prevention of esophageal stricture formation following caustic ingestion...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29207003/risk-factors-for-symptomatic-esophageal-stricture-after-caustic-ingestion-a-retrospective-cohort-study
#14
P Le Naoures, A Hamy, N Lerolle, E Métivier, E Lermite, A Venara
Esophageal stricture is a major secondary complication of ingesting caustic agents. We examined our experiences with caustic injuries with a view to finding clinical and biological risk factors of esophageal strictures secondary to caustic ingestion. Records were retrieved for 58 adults admitted consecutively to our intensive care unit for caustic ingestion. Fifty cases were managed conservatively and therefore retained for analyses. Patients were grouped according to whether they developed strictures or not during the follow-up period...
June 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29168156/the-anesthetic-management-of-button-battery-ingestion-in-children
#15
Richard J Ing, Monica Hoagland, Lena Mayes, Mark Twite
PURPOSE: Injuries related to button battery ingestion are common in children. This review provides an outline of the epidemiology, pathophysiology, management, and anesthetic implications in children who have ingested a button battery. SOURCE: A literature search was conducted in the United States National Library of Medicine PubMed database using the terms "button battery ingestion" and "children' and "removal" and "surgery" and "anesthesia"...
March 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29112883/a-new-paradigm-for-gerd-pathogenesis-not-acid-injury-but-cytokine-mediated-inflammation-driven-by-hif-2%C3%AE-a-potential-role-for-targeting-hif-2%C3%AE-to-prevent-and-treat-reflux-esophagitis
#16
REVIEW
Rhonda F Souza, Liela Bayeh, Stuart J Spechler, Uttam K Tambar, Richard K Bruick
Traditionally, reflux esophagitis was assumed to develop as a caustic, chemical injury inflicted by refluxed acid. Recently, however, studies in rats and humans suggest that reflux esophagitis develops as a cytokine-mediated inflammatory injury, with hypoxia inducible factor (HIF)-2α playing a major role. In response to the reflux of acid and bile, HIF-2α in esophageal epithelial cells becomes stabilized, thereby increasing production of pro-inflammatory cytokines that attract T lymphocytes and other inflammatory cells to damage the esophagus...
December 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28942656/use-of-self-expanding-nitinol-stents-in-the-pediatric-management-of-refractory-esophageal-caustic-stenosis
#17
Verónica Alonso, Devicka Ojha, Harsha Nalluri, Juan Carlos de Agustín
BACKGROUND: The treatment of recurrent esophageal stricture secondary to the ingestion of a caustic agent is an arduous task. Self-expanding esophageal stents may be an alternative to repeated endoscopic esophageal dilations. CASE REPORT: We present the case of a two-year-old male with a severe and long esophageal stricture successfully treated by the combination of dilations and stent placement. After five months of serial pneumatic dilations, three self-expanding nitinol stents internally coated with silicone were introduced through a gastrostomy, covering the entire esophagus...
October 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28894776/diagnostic-accuracy-of-computed-tomography-scan-in-detection-of-upper-gastrointestinal-tract-injuries-following-caustic-ingestion
#18
Hooman Bahrami-Motlagh, Mohammad Hadizadeh-Neisanghalb, Hassan Peyvandi
INTRODUCTION: Endoscopy is an invasive procedure and finding noninvasive alternative tools in detection of probable upper gastrointestinal (GI) tract injuries following caustic ingestion is an area of interest. The present study aimed to evaluate the screening performance characteristics of thoraco-abdominal computed tomography (CT) scan in this regard. METHODS: This prospective cross sectional study was conducted on patients presenting to emergency department following acute caustic ingestion...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28881910/effect-of-polaprezinc-on-experimental-corrosive-esophageal-burns-in-rats
#19
A Ozbayoglu, K Sonmez, R Karabulut, Z Turkyilmaz, A Poyraz, O Gulbahar, A C Basaklar
Unconsciously caustic ingestion is one of the most common causes of serious esophageal strictures in children. The aim of this study is to determine the efficiency of polaprezinc in preventing stricture formation after corrosive esophageal burns (CEB); this was the first time it has been used to treat experimental CEB in rats. Twenty-four rats were divided into four groups, three of which received CEB by the instillation of 1 mL of 10% NaOH solution into their isolated esophageal segments for three minutes...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28877001/total-laparoscopic-approach-for-transhiatal-esophagectomy-and-gavriliu-s-esophagoplasty-in-children-with-caustic-esophageal-injuries
#20
Louise Montalva, Jérôme Viala, Daphné Michelet, Fernanda Frade, Hubert Lardy, Christine Vitoux, Arnaud Bonnard
BACKGROUND: Esophageal repair after caustic injury is a surgical challenge in children. The aim of this study was to report the first results of a total laparoscopic approach in transhiatal esophagectomy and esophageal replacement by an anisoperistaltic gastric tube. PATIENTS AND METHODS: A retrospective review of data from children operated on with a laparoscopic approach for transhiatal esophagectomy and Gavriliu's esophagoplasty between 2011 and 2015 was performed...
October 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
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