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Nice classification

Luigi Gabrielli, María Paz Ocaranza, Marta Sitges, Andrés Kanacri, Rodrigo Saavedra, Pablo Sepulveda, Luis Sepulveda, Victor Rossel, Monica Zagolin, Hugo E Verdejo, Fernando Baraona, Ricardo Zalaquett, Mario Chiong, Sergio Lavandero, Pablo F Castro
BACKGROUND: Right atrium function and ventricular function have significant prognostic value in pulmonary arterial hypertension patients. Acute changes in right ventricular synchrony and right atrium function postiloprost inhalation have not been evaluated. METHODS: Cross-sectional study. Consecutive pulmonary arterial hypertension patients (group I from Nice classification) were included. Echocardiographic right atrium and right ventricular function pre- and postiloprost inhalation, including a right ventricular dyssynchrony index and right atrium function using speckle tracking, were performed in all patients...
October 14, 2016: Echocardiography
Willemijn M H Zijlstra, Johannes M Douwes, Mark-Jan Ploegstra, Usha Krishnan, Marcus T R Roofthooft, Hans L Hillege, D Dunbar Ivy, Erika B Rosenzweig, Rolf M F Berger
Congenital heart disease (CHD) is a frequent cause of pediatric pulmonary arterial hypertension (PAH), with diverse etiology and outcome. We aimed to describe phenotypic heterogeneity in pediatric PAH associated with CHD (PAH-CHD), assess the applicability of the Nice CHD classification, and explore whether this classification accurately reflects patient/disease characteristics and survival. All children with CHD from a contemporary cohort of consecutive pediatric PAH patients followed in three major referral centers (Denver, New York, the Netherlands) were characterized and classified on the basis of the latest proposed clinical classification for PAH-CHD (World Symposium on Pulmonary Hypertension, Nice, 2013)...
September 2016: Pulmonary Circulation
J Fistouris, C Bergh, A Strandell
STUDY QUESTION: How do four protocols based on serial human chorionic gonadotropin (hCG) measurements perform when classifying pregnancies of unknown location (PULs) as low or high risk of being an ectopic pregnancy (EP)? SUMMARY ANSWER: The use of cut-offs in hCG level changes published by NICE, and a logistic regression model, M4, correctly classify more PULs as high risk, compared with two other protocols. WHAT IS KNOWN ALREADY: A logistic regression model, M4, based on the mean of two consecutive hCG values and the hCG ratio (hCG 48 h/hCG 0 h) that classify PULs into low- and high-risk groups for triage purposes, identifies more EPs than a protocol using the cut-offs between a 13% decline and a 66% rise in hCG levels over 48 h...
October 2016: Human Reproduction
Amaya L Bustinduy, Irina Chis Ster, Rebecca Shaw, Adam Irwin, Jaiganesh Thiagarajan, Rhys Beynon, Shamez Ladhani, Mike Sharland
OBJECTIVE: To explore the risk factors for ward and paediatric assessment unit (PAU) admissions from the emergency department (ED). DESIGN: Prospective observational study. SETTING AND PATIENTS: Febrile children attending a large tertiary care ED during the winter of 2014-2015. MAIN OUTCOME MEASURES: Ward and PAU admissions, National Institute for Health and Care Excellence (NICE) guidelines classification, reattendance to the ED within 28 days and antibiotic use...
August 22, 2016: Archives of Disease in Childhood
Cindy M Padilla, Wahida Kihal-Talantikit, Sandra Perez, Severine Deguen
BACKGROUND: An environmental health inequality is a major public health concern in Europe. However just few studies take into account a large set of characteristics to analyze this problematic. The aim of this study was to identify and describe how socioeconomic, health accessibility and exposure factors accumulate and interact in small areas in a French urban context, to assess environmental health inequalities related to infant and neonatal mortality. METHODS: Environmental indicators on deprivation index, proximity to high-traffic roads, green space, and healthcare accessibility were created using the Geographical Information System...
2016: Environmental Health: a Global Access Science Source
Xiang Zhang, Yichao Wu, Lan Wang, Runze Li
Information criteria have been popularly used in model selection and proved to possess nice theoretical properties. For classification, Claeskens et al. (2008) proposed support vector machine information criterion for feature selection and provided encouraging numerical evidence. Yet no theoretical justification was given there. This work aims to fill the gap and to provide some theoretical justifications for support vector machine information criterion in both fixed and diverging model spaces. We first derive a uniform convergence rate for the support vector machine solution and then show that a modification of the support vector machine information criterion achieves model selection consistency even when the number of features diverges at an exponential rate of the sample size...
2016: Journal of Machine Learning Research: JMLR
Peter Auguste, Alexander Tsertsvadze, Joshua Pink, Rachel Court, Farah Seedat, Tara Gurung, Karoline Freeman, Sian Taylor-Phillips, Clare Walker, Jason Madan, Ngianga-Bakwin Kandala, Aileen Clarke, Paul Sutcliffe
BACKGROUND: Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) [(Zopf 1883) Lehmann and Neumann 1896], is a major cause of morbidity and mortality. Nearly one-third of the world's population is infected with MTB; TB has an annual incidence of 9 million new cases and each year causes 2 million deaths worldwide. OBJECTIVES: To investigate the clinical effectiveness and cost-effectiveness of screening tests [interferon-gamma release assays (IGRAs) and tuberculin skin tests (TSTs)] in latent tuberculosis infection (LTBI) diagnosis to support National Institute for Health and Care Excellence (NICE) guideline development for three population groups: children, immunocompromised people and those who have recently arrived in the UK from high-incidence countries...
May 2016: Health Technology Assessment: HTA
Colin J Rees, Praveen T Rajasekhar, Ana Wilson, Helen Close, Matthew D Rutter, Brian P Saunders, James E East, Rebecca Maier, Morgan Moorghen, Usman Muhammad, Helen Hancock, Anthoor Jayaprakash, Chris MacDonald, Arvind Ramadas, Anjan Dhar, James M Mason
BACKGROUND: Accurate optical characterisation and removal of small adenomas (<10 mm) at colonoscopy would allow hyperplastic polyps to be left in situ and surveillance intervals to be determined without the need for histopathology. Although accurate in specialist practice the performance of narrow band imaging (NBI), colonoscopy in routine clinical practice is poorly understood. METHODS: NBI-assisted optical diagnosis was compared with reference standard histopathological findings in a prospective, blinded study, which recruited adults undergoing routine colonoscopy in six general hospitals in the UK...
April 19, 2016: Gut
Peter Hammond
Type 1 diabetes affects around 370,000 adults in the UK, about 10% of all those diagnosed with diabetes. In type 1 diabetes there is a lack of beta cell insulin secretion as a result of autoimmune destruction of the beta cells. However, patients are not affected by insulin resistance, and so do not routinely experience the features of metabolic syndrome that occur in type 2 diabetes. NICE recommends considering further investigation with autoantibody testing or measurement of C-peptide when: type 1 diabetes is suspected but the presentation includes atypical features (e...
January 2016: Practitioner
Erik Tossavainen, Michael Y Henein, Christer Grönlund, Per Lindqvist
OBJECTIVES: We hypothesized that left atrial deformation during atrial systole (LASRa) correlates with pulmonary capillary wedge pressure (PCWP), thus enabling echo-derived pulmonary vascular resistance (PVR) estimation in a wide range of different subsets of patients. BACKGROUND: Various etiologies of pulmonary hypertension (PH) have different mechanisms and treatments for breathlessness. Irrespective of the location of the underlying pulmonary vascular pathology, pre- or postcapillary, the resulting PH is fairly easy to assess by Doppler echocardiography, but PVR remains a challenge...
August 2016: Echocardiography
Yunlong Feng, Yuning Yang, Xiaolin Huang, Siamak Mehrkanoon, Johan A K Suykens
This letter addresses the robustness problem when learning a large margin classifier in the presence of label noise. In our study, we achieve this purpose by proposing robustified large margin support vector machines. The robustness of the proposed robust support vector classifiers (RSVC), which is interpreted from a weighted viewpoint in this work, is due to the use of nonconvex classification losses. Besides the robustness, we also show that the proposed RSCV is simultaneously smooth, which again benefits from using smooth classification losses...
June 2016: Neural Computation
I-Chen Chen, Zen-Kong Dai
UNLABELLED: Compared with adult patients with pulmonary hypertension (PH), pulmonary vascular disease is characterized by complex heterogeneity in pediatric patients. The Nice PH classification does not completely characterize or individualize any subgroup of pediatric PH. This is in contrast to the Panama classification, in which prenatal and fetal origins of many pulmonary vascular diseases in neonates and children, perinatal pulmonary vascular maladaptation, prenatal and postnatal pulmonary vascular mal-development, and pulmonary vascular hypoplasia are included...
November 2015: Acta Cardiol Sin
Antoine Italiano, Ilaria Di Mauro, Jocelyn Rapp, Gaëlle Pierron, Nathalie Auger, Laurent Alberti, Frédéric Chibon, Fabienne Escande, Anne-Claire Voegeli, Jean-Pierre Ghnassia, Frédérique Keslair, Marick Laé, Dominique Ranchère-Vince, Philippe Terrier, Sandrine Baffert, Jean-Michel Coindre, Florence Pedeutour
BACKGROUND: Advances in molecular genetics of sarcoma have enabled the identification of type-specific aberrations. We aimed to assess the clinical effect of systematic implementation of molecular assays to improve sarcoma misdiagnosis. METHODS: In this multicentre, observational study, we recruited patients from 32 centres of the French Sarcoma Group/Reference Network in Pathology of Sarcomas. Eligibility criteria included: biopsy or surgical resection; suspicion of: dermatofibrosarcoma protuberans (cohort 1), dedifferentiated liposarcoma (cohort 2), Ewing's sarcoma family of tumours (cohort 3), synovial sarcoma (cohort 4), alveolar rhabdomyosarcoma (cohort 5), and myxoid or round cell liposarcoma (cohort 6); review by one sarcoma-expert pathologist; availability of frozen material (except for cohort 1 of patients with dermatofibrosarcoma protuberans because anti-CD34 immunohistochemistry is performed on paraffin-embedded tissue); and patient information...
April 2016: Lancet Oncology
Alessandro Repici, Camilla Ciscato, Loredana Correale, Raf Bisschops, Pradeep Bhandari, Evelien Dekker, Oliver Pech, Franco Radaelli, Cesare Hassan
BACKGROUND AND AIMS: The Narrow-band Imaging International Colorectal Endoscopic (NICE) Classification has been validated for differentiating hyperplastic from adenomatous polyps. This classification system was based on narrow-band imaging (NBI) technology, leaving uncertainty regarding its applicability to other systems. The aim of this study was to assess accuracy and reliability of histologic predictions for polyps <1 cm by applying the NICE classification to the Fujinon Spectral Imaging Color Enhancement (FICE) System...
September 2016: Gastrointestinal Endoscopy
Tate Nice, Benjamin Tuanama Diaz, Michelle Shroyer, David Rogers, Mike Chen, Colin Martin, Elizabeth Beierle, Beverly Chaignaud, Scott Anderson, Robert Russell
PURPOSE: Esophageal stricture remains a common morbidity of esophageal atresia (EA) repair. The purpose of this study was to examine the association of multiple pre- and postoperative variables with stricture formation after EA repair. METHODS: A retrospective review of all patients who underwent EA repair was performed from June 1999 to January 2014, excluding patients who died prior to discharge. Data were collected on patient demographics, disease specifics, treatment, and outcomes...
May 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Depeng Wang, Yun Wu, Jun Xia
Photoacoustic (PA) tomography (PAT) is a hybrid imaging modality that integrates rich optical contrasts with a high-ultrasonic spatial resolution in deep tissue. Among various imaging applications, PA neuroimaging is becoming increasingly important as it nicely complements the limitations of conventional neuroimaging modalities, such as the low-temporal resolution in magnetic resonance imaging and the low depth-to-resolution ratio in optical microscopy/tomography. In addition, the intrinsic hemoglobin contrast PA neuroimaging has also been greatly improved by recent developments in nanoparticles (NPs)...
January 2016: Neurophotonics
Yinhe Sikong, Xiangchun Lin, Kuiliang Liu, Jing Wu, Wu Lin, Nan Wei, Guojun Jiang, Weiping Tai, Hui Su, Hong Liu, Mingming Meng
BACKGROUND AND AIM: To evaluate the effectiveness of systematic training in the application of narrow-band imaging (NBI) International Colorectal Endoscopic (NICE) classification for the prediction of the histology of colorectal polyps. METHODS: This is a single-center study. In total, 260 still images of colorectal polyps from 225 patients were included. Two series of 130 images obtained using NBI and white light without magnification were distributed to 10 endoscopists-five highly experienced endoscopists (HEE group) and five less experienced endoscopists (LEE group)-for assessment using the NICE classification, before and after systematic training...
July 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Dan Wang, Kristopher Attwood, Lili Tian
Receiver operating characteristic (ROC) curve and its summary statistics (e.g., the area under curve (AUC)) are commonly used to evaluate the diagnostic accuracy for disease processes with binary classification. The ROC curve has been extended to ROC surface for scenarios with three ordinal classes or to hyper-surface for scenarios with more than three classes. For classifier under tree or umbrella ordering in which the marker measurement for one class is lower or higher than those for the other classes, the commonly adopted diagnostic measures are the naive AUC (NAUC) based on a pooled class of all the unordered classes and the umbrella volume (UV) based on the concept of volume under surface...
May 20, 2016: Statistics in Medicine
Anwar M Batieha, Yousef S Khader, Nino Berdzuli, Chuanpit Chua-Oon, Eman F Badran, Nihaya A Al-Sheyab, Asma S Basha, Ahmad Obaidat, Ra'eda J Al-Qutob
OBJECTIVE: The present study aimed at assessment of the magnitude of neonatal mortality in Jordan, and its causes and associated factors. METHODS: Through a multistage sampling technique, a total of 21,928 deliveries with a gestational period ≥20 weeks from 18 hospitals were included in the study. The status of their babies 28 days after birth, whether dead or alive, was ascertained. Extensive data were collected about mothers and their newborns at admission and after 28 days of birth...
May 2016: Maternal and Child Health Journal
F R J Groen, D Delawi, M C Kruyt, F C Oner
PURPOSE: This study aimed at discussing the relevance of the type B3 fracture of the new AOSpine classification. METHODS: Hyperextension fractures of the spine are rare in the general population, but common in the ankylotic spine. We present a case of a severe spinal fracture with concomitant esophageal rupture, which was diagnosed early and could be treated during the initial trauma care. RESULTS: The spinal column was stabilized using a percutaneous technique after which the perforated esophagus was sutured through a thoracotomy...
May 2016: European Spine Journal
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