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https://www.readbyqxmd.com/read/29674186/pulmonary-hypertension-real-world-data-from-a-portuguese-expert-referral-centre
#1
A Gomes, C Cruz, J Rocha, M Ricardo, M Vicente, A Melo, M Santos, L Carvalho, F Gonçalves, A Reis
BACKGROUND: Pulmonary hypertension (PH) is a heterogeneous, debilitating condition with highly relevant impact on functional capacity, quality of life, and life-expectancy. OBJECTIVES: This study aims to provide long-term data on the Portuguese PH population, by characterising the clinical presentation, evolution, and outcomes of PH patients in a specialised referral centre. METHODS: Retrospective analysis of a cohort of 101 patients with pre-capillary PH (pcPH) referenced to an expert tertiary care referral centre in northern Portugal from 2002 to 2013...
April 16, 2018: Pulmonology
https://www.readbyqxmd.com/read/29656581/the-jnet-classification-nbi-magnifying-endoscopic-classification-of-colorectal-tumors
#2
Yasushi Sano, Daizen Hirata, Yutaka Saito
The NICE classification is widely used around the world as a universal NBI endoscopic classification that is available without magnifying endoscopy. On the other hand, as histopathological criteria of curative endoscopic resection for early colorectal cancers is getting clear in Japan, endoscopists are required to diagnose their invasion depth accurately with magnifying endoscopy and obtain deeper histopathological materials by endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD). Therefore, we need a new classification which provides accurate qualitative and quantitative diagnosis linking to the appropriate treatment strategy including polypectomy, EMR/ESD, and surgery...
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29645347/does-the-introduction-of-prostate-multiparametric-mri-into-active-surveillance-of-localised-prostate-cancer-improve-patient-re-classification
#3
R J Bryant, B Yang, Y Philippou, K Lam, M Obiakor, J Ayers, V Chiocchia, F Gleeson, R MacPherson, C Verrill, P Sooriakumaran, F C Hamdy, S F Brewster
OBJECTIVES: To determine whether replacement of protocol-driven repeat prostate biopsy (PB) with multiparametric magnetic resonance imaging (mpMRI) +/- targeted repeat prostate biopsy (TB) in evaluating men on active surveillance (AS) for low-volume low- to intermediate-risk prostate cancer (PCa) altered the likelihood or time to treatment, or reduced the number of repeat biopsies required to trigger treatment. PATIENTS AND METHODS: 445 patients underwent AS from 2010-2016 at our institution with median follow-up of 2...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29463046/a-novel-hard-decision-based-simultaneous-target-tracking-and-classification-approach
#4
Wen Cao, Meng Hui, Qisheng Wu
Methods dealing with the problem of Joint Tracking and Classification (JTC) are abundant, among which Simultaneous Tracking and Classification (STC) provides a modularized scheme solving tracking and classification subproblems simultaneously. However, there is no explicit hard decision on the class label but only soft decision (class probability) is provided. This does not fit many practical cases, in which a hard decision is urgently needed. To solve this problem, this paper proposes a Hard decision-based STC (HSTC) method...
February 19, 2018: Sensors
https://www.readbyqxmd.com/read/29432063/approach-to-pulmonary-hypertension-from-ct-to-clinical-diagnosis
#5
Felipe Aluja Jaramillo, Fernando R Gutierrez, Federico G Díaz Telli, Sebastian Yevenes Aravena, Cylen Javidan-Nejad, Sanjeev Bhalla
Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary circulation. It may be idiopathic or arise in the setting of other clinical conditions. Patients with PH tend to present with nonspecific cardiovascular or respiratory symptoms. The clinical classification of PH was recently revised at the World Health Organization symposium in Nice, France, in 2013. That consensus statement provided an updated classification based on the shared hemodynamic characteristics and management of the different categories of PH...
February 12, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29331010/implants-for-extracapsular-neck-of-femur-fracture-dynamic-hip-screw-versus-intramedullary-nailing
#6
Faisal Farooq Butt, Adnan Shabbair Hussain, Ahmed Mushtaq Khan, Maria Sultan
Neck of femur fractures are the most prevalent type of injury in elderly trauma patients. Both intra and extra capsular type of fractures are equally distributed in the given population. Traditionally, Extra capsular fractures are fixed with Dynamic Hip screw or Intra medullary nailing based on the type of fracture. NICE (National Institute of Clinical Excellence) recommends fixing 31-A1 and 31-A2 fractures with DHS (Dynamic Hip Screw) whereas AO recommends fixing 31-A1 with DHS and 31-A2.1 subtype with DHS and 31-A2...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29310484/pathology-proteomics-and-the-pathway-to-personalised-medicine
#7
Ping Jin, Jiang Lan, Kui Wang, Mark S Baker, Canhua Huang, Edouard C Nice
As we move from a discovery to a translational phase in proteomics, with a focus on developing validated clinical assays to assist personalized medicine, there is a growing need for strong bidirectional interactions with the clinical pathology community. Thus, while on one hand the proteomics community will provide candidate biomarkers to assist in diagnosis, prognosis, surveillance, identification of individualized patient medication, and development and validation of new assays for diagnostic use, on the other the pathology community will assist with specific tissue identification and selection (e...
March 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29228454/new-semiparametric-method-for-predicting-high-cost-patients
#8
Adam Maidman, Lan Wang
Motivated by the Medical Expenditure Panel Survey containing data from individuals' medical providers and employers across the United States, we propose a new semiparametric procedure for predicting whether a patient will incur high medical expenditure. Problems of the same nature arise in many other important applications where one would like to predict if a future response occurs at the upper (or lower) tail of the response distribution. The common practice is to artificially dichotomize the response variable and then apply an existing classification method such as binomial regression or a classification tree...
December 11, 2017: Biometrics
https://www.readbyqxmd.com/read/29162242/current-concepts-in-spondylopelvic-dissociation
#9
REVIEW
André Luiz Loyelo Barcellos, Vinícius M da Rocha, João Antonio Matheus Guimarães
INTRODUCTION: Spondylopelvic dissociation is an uncommon and complex injury that results from high-energy trauma with axial overloading through the sacrum. Due to the life-threatening nature of these injuries, standard Advanced Trauma Life Support® (ATLS) protocol must be used in the trauma setting as part of the initial management of these patients. The key to diagnosis is a good physical exam coupled with high level of suspicion. Radicular neurological deficits commonly are present in spondylopelvic dissociation (L5's roots) and should be documented for future evaluations...
November 2017: Injury
https://www.readbyqxmd.com/read/29125866/inconsistent-selection-of-outcomes-and-measurement-devices-found-in-shoulder-arthroplasty-research-an-analysis-of-studies-on-clinicaltrials-gov
#10
Matthew Thomas Sims, Byron Nice Detweiler, Jared Thomas Scott, Benjamin McKinnley Howard, Grant Richard Detten, Matt Vassar
INTRODUCTION: Recent evidence suggests a lack of standardization of shoulder arthroplasty outcomes. This issue is a limiting factor in systematic reviews. Core outcome set (COS) methodology could address this problem by delineating a minimum set of outcomes for measurement in all shoulder arthroplasty trials. METHODS: A ClinicalTrials.gov search yielded 114 results. Eligible trials were coded on the following characteristics: study status, study type, arthroplasty type, sample size, measured outcomes, outcome measurement device, specific metric of measurement, method of aggregation, outcome classification, and adverse events...
2017: PloS One
https://www.readbyqxmd.com/read/29042789/linked-color-imaging-combined-with-the-nice-classification-system-for-optical-diagnosis-of-colon-polyps-new-image-enhanced-endoscopic-technology-for-pathological-prediction
#11
Chi-Huan Wu, Tsung-Hsing Chen, Chen-Ming Hsu, Ming-Yao Su, Cheng-Tang Chiu, Ren-Chin Wu, Cheng-Chou Lai
INTRODUCTION: Linked-color imaging (LCI) is a recently developed system used in endoscopy. It creates clear and bright endoscopic images using short-wavelength, narrow-band laser light combined with white laser light. The illuminating light and signal processing emphasize slight color differences in abnormal regions that approximate the normal color of the mucosa. As a result, regions initially appearing red become a deeper shade of red, while regions originally appearing white become brighter, yet with natural tones...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29039837/-a-patient-with-severe-idiopathic-pulmonary-arterial-hypertension-is-there-a-way-out
#12
N A Tsareva, S N Avdeev, G V Neklyudova
The paper considers a clinical example of current therapy for idiopathic pulmonary arterial hypertension in a female patient with its clinical deterioration. It shows the tactics of switching from one drug (bosentan) to others (macitentan) within in the same pathogenetic therapy group (endothelin receptor antagonists). The latest pulmonary hypertension classification (Nice, 2013) is presented. The current strategies of pathogenetic therapy for pulmonary hypertension are discussed.
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28922737/economic-evaluations-of-internet-and-mobile-based-interventions-for-the-treatment-and-prevention-of-depression-a-systematic-review
#13
REVIEW
Sarah Paganini, Wiebke Teigelkötter, Claudia Buntrock, Harald Baumeister
BACKGROUND: Internet- and mobile-based interventions (IMIs) targeting depression have been shown to be clinically effective and are considered a cost-effective complement to established interventions. The aim of this review was to provide an overview of the evidence for the cost-effectiveness of IMIs for the treatment and prevention of depression. METHODS: A systematic database search was conducted (Medline, PsychInfo, CENTRAL, PSYNDEX, OHE HEED). Relevant articles were selected according to defined eligibility criteria...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28756134/molecular-phylogeny-of-pasiphaeidae-crustacea-decapoda-caridea-reveals-systematic-incongruence-of-the-current-classification
#14
Yunshi Liao, Sammy De Grave, Tsz Wai Ho, Brian H Y Ip, Ling Ming Tsang, Tin-Yam Chan, Ka Hou Chu
Caridean shrimps constitute one of the most diverse groups of decapod crustaceans, notwithstanding their poorly resolved infraordinal relationships. One of the systematically controversial families in Caridea is the predominantly pelagic Pasiphaeidae, comprises 101 species in seven genera. Pasiphaeidae species exhibit high morphological disparity, as well as ecological niche width, inhabiting shallow to very deep waters (>4000m). The present work presents the first molecular phylogeny of the family, based on a combined dataset of six mitochondrial and nuclear gene markers (12S rDNA, 16S rDNA, histone 3, sodium-potassium ATPase α-subunit, enolase and ATP synthase β-subunit) from 33 species belonged to six genera of Pasiphaeidae with 19 species from 12 other caridean families as outgroup taxa...
October 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28625310/mise-%C3%A3-jour-2016-des-recommandations-pour-la-pratique-clinique-de-nice-saint-paul-de-vence-dans-le-cancer-de-l%C3%A2-ovaire-et-du-col-de-l%C3%A2-ut%C3%A3-rus-%C3%A3-un-stade-avanc%C3%A3
#15
Florence Joly, Denis Querleu, Moise Namer, Eric Pujade-Lauraine
UPDATED 2016 RECOMMENDATIONS FOR THE CLINICAL PRACTICE OF NICE/SAINT-PAUL-DE-VENCE IN OVARIAN CANCER AND ADVANCED CERVICAL CANCER: Since the first edition of the 2012-2013 Clinical Practice Recommendations Nice-Saint-Paul for gynecological cancers, the management of ovarian cancer has become more complex with a better definition of histological subtypes of ovarian cancers, the update of the anatomo-clinical classifications, the evolution of the recommended quality criteria for surgery. In addition, the integration of new medical options, such as PARP inhibitors, requires us to review our management of ovarian cnacer patients (including early systematic oncogenetic research of homologous recombination pathway deficiency)...
May 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28574989/optimal-classifier-for-imbalanced-data-using-matthews-correlation-coefficient-metric
#16
Sabri Boughorbel, Fethi Jarray, Mohammed El-Anbari
Data imbalance is frequently encountered in biomedical applications. Resampling techniques can be used in binary classification to tackle this issue. However such solutions are not desired when the number of samples in the small class is limited. Moreover the use of inadequate performance metrics, such as accuracy, lead to poor generalization results because the classifiers tend to predict the largest size class. One of the good approaches to deal with this issue is to optimize performance metrics that are designed to handle data imbalance...
2017: PloS One
https://www.readbyqxmd.com/read/28389440/haematological-cancers-improving-outcomes-a-summary-of-updated-nice-service-guidance-in-relation-to-specialist-integrated-haematological-malignancy-diagnostic-services-sihmds
#17
REVIEW
John A Snowden, Susan O'Connell, James Hawkins, Chris Dalley, Andrew Jack, Deepak Mannari, Chris McNamara, Mike Scott, Geoff Shenton, Elizabeth Soilleux, Fergus Macbeth
Haematological malignancies are a diverse group of cancers that affect the blood, bone marrow and lymphatic systems. Laboratory diagnosis of haematological malignancies is dependent on combining several technologies, including morphology, immunophenotyping, cytogenetics and molecular genetics correlated clinical details and classification according to the current WHO guidelines. The concept of the Specialised Integrated Haematological Malignancy Diagnostic Services (SIHMDS) has evolved since the UK National Institute for Health and Care Excellence (NICE) Improving Outcomes Guidance (IOG) in 2003 and subsequently various models of delivery have been established...
June 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28381378/severe-acute-pancreatitis-pathogenesis-diagnosis-and-surgical-management
#18
REVIEW
Mark Portelli, Christopher David Jones
BACKGROUND: Severe acute pancreatitis is a subtype of acute pancreatitis, associated with multiple organ failure and systemic inflammatory response syndrome. In this qualitative review we looked at the principles of pathogenesis, classification and surgical management of severe acute pancreatitis. We also looked at the current shift in paradigm in the management of severe acute pancreatitis since the guideline developed by the British Society of Gastroenterology. DATA SOURCES: Studies published between 1st January 1991 and 31st December 2015 were identified with PubMed, MEDLINE, EMBASE and Google Scholar online search engines using the following Medical Subject Headings: "acute pancreatitis, necrosis, mortality, pathogenesis, incidence" and the terms "open necrosectomy and minimally invasive necrosectomy"...
April 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28378694/the-role-of-narrow-band-imaging-in-colorectal-polyp-detection
#19
Irina Ioana Vișovan, Marcel Tanțău, Oliviu Pascu, Lidia Ciobanu, Alina Tanțău
Colonoscopic detection and removal of polyps represent the most important prevention method for colorectal cancer. We aimed to investigate the diagnostic yield of narrow band imaging (NBI) colonoscopy for polyp detection compared with standard colonoscopy. In this prospective study, 505 patients that underwent total colonoscopy were randomized into two groups: 226 patients in NBI group and 279 in non-NBI group (standard colonoscopy). The primary endpoints were polyp detection rate (PDR) and adenoma detection rate (ADR) in both groups...
May 20, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28346664/a-cross-sectional-comparison-of-three-guidelines-for-intrapartum-cardiotocography
#20
COMPARATIVE STUDY
Meena Bhatia, Kamal R Mahtani, David Nunan, Aparna Reddy
OBJECTIVE: To compare the cardiotocography classification systems outlined by the International Federation of Gynecology and Obstetrics (FIGO) in 2015 and the UK National Institute for Health and Care Excellence (NICE) in 2007 and 2014. METHODS: A cross-sectional observational study of cardiotocography practices at a UK hospital was conducted among labor ward staff (n=21) from November 1 to November 31, 2015. All observers classified ten cardiotocography traces according to the three guidelines using a bespoke form...
July 2017: International Journal of Gynaecology and Obstetrics
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