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https://www.readbyqxmd.com/read/29885688/pulmonary-hypertension-registry-of-kerala-india-pro-kerala-clinical-characteristics-and-practice-patterns
#1
S Harikrishnan, G Sanjay, M Ashishkumar, Jaideep Menon, Gopalan Nair Rajesh, Raman Krishna Kumar, A George Koshy, Thankachan V Attacheril, Raju George, Eapen Punnoose, S M Ashraf, S R Arun, Mohammed Cholakkal, Panniyammakal Jeemon
BACKGROUND: Epidemiological data on pulmonary hypertension (PH) are scarce from developing countries including India. METHODS: We established a multi-center registry of PH, the PRO-KERALA registry, in Kerala, India. Fifty hospitals enrolled consecutive adult (>18 years) patients for one year. Echocardiographic criteria (right ventricular systolic pressure - RVSP > 50 mmHg) or invasively obtained mean pulmonary artery pressure > 25 mmHg was the criteria for entry...
August 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29867410/diagnosis-of-autism-spectrum-disorders-using-multi-level-high-order-functional-networks-derived-from-resting-state-functional-mri
#2
Feng Zhao, Han Zhang, Islem Rekik, Zhiyong An, Dinggang Shen
Functional brain networks derived from resting-state functional magnetic resonance imaging (rs-fMRI) have been widely used for Autism Spectrum Disorder (ASD) diagnosis. Typically, these networks are constructed by calculating functional connectivity (FC) between any pair of brain regions of interest (ROIs), i.e., using Pearson's correlation between rs-fMRI time series. However, this can only be called as a low-order representation of the functional interaction, because the relationship is investigated just between two ROIs...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29761488/psychological-therapies-for-treatment-resistant-depression-in-adults
#3
REVIEW
Sharea Ijaz, Philippa Davies, Catherine J Williams, David Kessler, Glyn Lewis, Nicola Wiles
BACKGROUND: Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for Health and Care Excellence (NICE) guidance suggests that the 'next step' for those who do not respond to antidepressants may include a change in the dose or type of antidepressant medication, the addition of another medication, or the start of psychotherapy...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29725349/diagnostic-accuracy-of-nice-classification-system-for-optical-recognition-of-predictive-morphology-of-colorectal-polyps
#4
Josipa Patrun, Lucija Okreša, Hrvoje Iveković, Nadan Rustemović
The NICE classification is an international endoscopic classification of colorectal neoplasia through a narrowband spectrum that on the basis of lesion colors, vascular pattern, and structure of the surface of the mucous membrane classifies colorectal neoplasms in three categories: type 1 as hyperplastic lesions, type 2 as adenomas, and type 3 as invasive tumors. The aim of this study was to verify diagnostic accuracy of the NICE classification system compared to the reference standard: histopathological analysis...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29674186/pulmonary-hypertension-real-world-data-from-a-portuguese-expert-referral-centre
#5
A Gomes, C Cruz, J Rocha, M Ricardo, M Vicente, A Melo, M Santos, L Carvalho, F Gonçalves, A Reis
BACKGROUND: Pulmonary hypertension (PH) is a heterogeneous, debilitating condition with highly relevant impact on functional capacity, quality of life, and life-expectancy. OBJECTIVES: This study aims to provide long-term data on the Portuguese PH population, by characterising the clinical presentation, evolution, and outcomes of PH patients in a specialised referral centre. METHODS: Retrospective analysis of a cohort of 101 patients with pre-capillary PH (pcPH) referenced to an expert tertiary care referral centre in northern Portugal from 2002 to 2013...
April 16, 2018: Pulmonology
https://www.readbyqxmd.com/read/29656581/japan-nbi-expert-team-classification-narrow-band-imaging-magnifying-endoscopic-classification-of-colorectal-tumors
#6
Yasushi Sano, Daizen Hirata, Yutaka Saito
No abstract text is available yet for this article.
April 14, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29645347/does-the-introduction-of-prostate-multiparametric-magnetic-resonance-imaging-into-the-active-surveillance-protocol-for-localized-prostate-cancer-improve-patient-re-classification
#7
Richard J Bryant, Bob Yang, Yiannis Philippou, Karla Lam, Maureen Obiakor, Jennifer Ayers, Virginia Chiocchia, Fergus Gleeson, Ruth MacPherson, Clare Verrill, Prasanna Sooriakumaran, Freddie C Hamdy, Simon F Brewster
OBJECTIVES: To determine whether replacement of protocol-driven repeat prostate biopsy (PB) with multiparametric magnetic resonance imaging (mpMRI) ± repeat targeted prostate biopsy (TB) when evaluating men on active surveillance (AS) for low-volume, low- to intermediate-risk prostate cancer (PCa) altered the likelihood of or time to treatment, or reduced the number of repeat biopsies required to trigger treatment. PATIENTS AND METHODS: A total of 445 patients underwent AS in the period 2010-2016 at our institution, with a median (interquartile range [IQR]) follow-up of 2...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29463046/a-novel-hard-decision-based-simultaneous-target-tracking-and-classification-approach
#8
Wen Cao, Meng Hui, Qisheng Wu
Methods dealing with the problem of Joint Tracking and Classification (JTC) are abundant, among which Simultaneous Tracking and Classification (STC) provides a modularized scheme solving tracking and classification subproblems simultaneously. However, there is no explicit hard decision on the class label but only soft decision (class probability) is provided. This does not fit many practical cases, in which a hard decision is urgently needed. To solve this problem, this paper proposes a Hard decision-based STC (HSTC) method...
February 19, 2018: Sensors
https://www.readbyqxmd.com/read/29432063/approach-to-pulmonary-hypertension-from-ct-to-clinical-diagnosis
#9
Felipe Aluja Jaramillo, Fernando R Gutierrez, Federico G Díaz Telli, Sebastian Yevenes Aravena, Cylen Javidan-Nejad, Sanjeev Bhalla
Pulmonary hypertension (PH) is a condition characterized by increased pressure in the pulmonary circulation. It may be idiopathic or arise in the setting of other clinical conditions. Patients with PH tend to present with nonspecific cardiovascular or respiratory symptoms. The clinical classification of PH was recently revised at the World Health Organization symposium in Nice, France, in 2013. That consensus statement provided an updated classification based on the shared hemodynamic characteristics and management of the different categories of PH...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29331010/implants-for-extracapsular-neck-of-femur-fracture-dynamic-hip-screw-versus-intramedullary-nailing
#10
Faisal Farooq Butt, Adnan Shabbair Hussain, Ahmed Mushtaq Khan, Maria Sultan
Neck of femur fractures are the most prevalent type of injury in elderly trauma patients. Both intra and extra capsular type of fractures are equally distributed in the given population. Traditionally, Extra capsular fractures are fixed with Dynamic Hip screw or Intra medullary nailing based on the type of fracture. NICE (National Institute of Clinical Excellence) recommends fixing 31-A1 and 31-A2 fractures with DHS (Dynamic Hip Screw) whereas AO recommends fixing 31-A1 with DHS and 31-A2.1 subtype with DHS and 31-A2...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29310484/pathology-proteomics-and-the-pathway-to-personalised-medicine
#11
Ping Jin, Jiang Lan, Kui Wang, Mark S Baker, Canhua Huang, Edouard C Nice
As we move from a discovery to a translational phase in proteomics, with a focus on developing validated clinical assays to assist personalized medicine, there is a growing need for strong bidirectional interactions with the clinical pathology community. Thus, while on one hand the proteomics community will provide candidate biomarkers to assist in diagnosis, prognosis, surveillance, identification of individualized patient medication, and development and validation of new assays for diagnostic use, on the other the pathology community will assist with specific tissue identification and selection (e...
March 2018: Expert Review of Proteomics
https://www.readbyqxmd.com/read/29228454/new-semiparametric-method-for-predicting-high-cost-patients
#12
Adam Maidman, Lan Wang
Motivated by the Medical Expenditure Panel Survey containing data from individuals' medical providers and employers across the United States, we propose a new semiparametric procedure for predicting whether a patient will incur high medical expenditure. Problems of the same nature arise in many other important applications where one would like to predict if a future response occurs at the upper (or lower) tail of the response distribution. The common practice is to artificially dichotomize the response variable and then apply an existing classification method such as binomial regression or a classification tree...
December 11, 2017: Biometrics
https://www.readbyqxmd.com/read/29162242/current-concepts-in-spondylopelvic-dissociation
#13
REVIEW
André Luiz Loyelo Barcellos, Vinícius M da Rocha, João Antonio Matheus Guimarães
INTRODUCTION: Spondylopelvic dissociation is an uncommon and complex injury that results from high-energy trauma with axial overloading through the sacrum. Due to the life-threatening nature of these injuries, standard Advanced Trauma Life Support® (ATLS) protocol must be used in the trauma setting as part of the initial management of these patients. The key to diagnosis is a good physical exam coupled with high level of suspicion. Radicular neurological deficits commonly are present in spondylopelvic dissociation (L5's roots) and should be documented for future evaluations...
November 2017: Injury
https://www.readbyqxmd.com/read/29125866/inconsistent-selection-of-outcomes-and-measurement-devices-found-in-shoulder-arthroplasty-research-an-analysis-of-studies-on-clinicaltrials-gov
#14
Matthew Thomas Sims, Byron Nice Detweiler, Jared Thomas Scott, Benjamin McKinnley Howard, Grant Richard Detten, Matt Vassar
INTRODUCTION: Recent evidence suggests a lack of standardization of shoulder arthroplasty outcomes. This issue is a limiting factor in systematic reviews. Core outcome set (COS) methodology could address this problem by delineating a minimum set of outcomes for measurement in all shoulder arthroplasty trials. METHODS: A ClinicalTrials.gov search yielded 114 results. Eligible trials were coded on the following characteristics: study status, study type, arthroplasty type, sample size, measured outcomes, outcome measurement device, specific metric of measurement, method of aggregation, outcome classification, and adverse events...
2017: PloS One
https://www.readbyqxmd.com/read/29042789/linked-color-imaging-combined-with-the-nice-classification-system-for-optical-diagnosis-of-colon-polyps-new-image-enhanced-endoscopic-technology-for-pathological-prediction
#15
Chi-Huan Wu, Tsung-Hsing Chen, Chen-Ming Hsu, Ming-Yao Su, Cheng-Tang Chiu, Ren-Chin Wu, Cheng-Chou Lai
INTRODUCTION: Linked-color imaging (LCI) is a recently developed system used in endoscopy. It creates clear and bright endoscopic images using short-wavelength, narrow-band laser light combined with white laser light. The illuminating light and signal processing emphasize slight color differences in abnormal regions that approximate the normal color of the mucosa. As a result, regions initially appearing red become a deeper shade of red, while regions originally appearing white become brighter, yet with natural tones...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29039837/-a-patient-with-severe-idiopathic-pulmonary-arterial-hypertension-is-there-a-way-out
#16
N A Tsareva, S N Avdeev, G V Neklyudova
The paper considers a clinical example of current therapy for idiopathic pulmonary arterial hypertension in a female patient with its clinical deterioration. It shows the tactics of switching from one drug (bosentan) to others (macitentan) within in the same pathogenetic therapy group (endothelin receptor antagonists). The latest pulmonary hypertension classification (Nice, 2013) is presented. The current strategies of pathogenetic therapy for pulmonary hypertension are discussed.
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28922737/economic-evaluations-of-internet-and-mobile-based-interventions-for-the-treatment-and-prevention-of-depression-a-systematic-review
#17
REVIEW
Sarah Paganini, Wiebke Teigelkötter, Claudia Buntrock, Harald Baumeister
BACKGROUND: Internet- and mobile-based interventions (IMIs) targeting depression have been shown to be clinically effective and are considered a cost-effective complement to established interventions. The aim of this review was to provide an overview of the evidence for the cost-effectiveness of IMIs for the treatment and prevention of depression. METHODS: A systematic database search was conducted (Medline, PsychInfo, CENTRAL, PSYNDEX, OHE HEED). Relevant articles were selected according to defined eligibility criteria...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28756134/molecular-phylogeny-of-pasiphaeidae-crustacea-decapoda-caridea-reveals-systematic-incongruence-of-the-current-classification
#18
Yunshi Liao, Sammy De Grave, Tsz Wai Ho, Brian H Y Ip, Ling Ming Tsang, Tin-Yam Chan, Ka Hou Chu
Caridean shrimps constitute one of the most diverse groups of decapod crustaceans, notwithstanding their poorly resolved infraordinal relationships. One of the systematically controversial families in Caridea is the predominantly pelagic Pasiphaeidae, comprises 101 species in seven genera. Pasiphaeidae species exhibit high morphological disparity, as well as ecological niche width, inhabiting shallow to very deep waters (>4000m). The present work presents the first molecular phylogeny of the family, based on a combined dataset of six mitochondrial and nuclear gene markers (12S rDNA, 16S rDNA, histone 3, sodium-potassium ATPase α-subunit, enolase and ATP synthase β-subunit) from 33 species belonged to six genera of Pasiphaeidae with 19 species from 12 other caridean families as outgroup taxa...
October 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28625310/mise-%C3%A3-jour-2016-des-recommandations-pour-la-pratique-clinique-de-nice-saint-paul-de-vence-dans-le-cancer-de-l%C3%A2-ovaire-et-du-col-de-l%C3%A2-ut%C3%A3-rus-%C3%A3-un-stade-avanc%C3%A3
#19
Florence Joly, Denis Querleu, Moise Namer, Eric Pujade-Lauraine
UPDATED 2016 RECOMMENDATIONS FOR THE CLINICAL PRACTICE OF NICE/SAINT-PAUL-DE-VENCE IN OVARIAN CANCER AND ADVANCED CERVICAL CANCER: Since the first edition of the 2012-2013 Clinical Practice Recommendations Nice-Saint-Paul for gynecological cancers, the management of ovarian cancer has become more complex with a better definition of histological subtypes of ovarian cancers, the update of the anatomo-clinical classifications, the evolution of the recommended quality criteria for surgery. In addition, the integration of new medical options, such as PARP inhibitors, requires us to review our management of ovarian cnacer patients (including early systematic oncogenetic research of homologous recombination pathway deficiency)...
May 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28574989/optimal-classifier-for-imbalanced-data-using-matthews-correlation-coefficient-metric
#20
Sabri Boughorbel, Fethi Jarray, Mohammed El-Anbari
Data imbalance is frequently encountered in biomedical applications. Resampling techniques can be used in binary classification to tackle this issue. However such solutions are not desired when the number of samples in the small class is limited. Moreover the use of inadequate performance metrics, such as accuracy, lead to poor generalization results because the classifiers tend to predict the largest size class. One of the good approaches to deal with this issue is to optimize performance metrics that are designed to handle data imbalance...
2017: PloS One
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