Bowen Li, Hui Ming, Siyuan Qin, Li Zhou, Zhao Huang, Ping Jin, Liyuan Peng, Maochao Luo, Tingting Zhang, Kui Wang, Rui Liu, Yih-Cherng Liou, Edouard C Nice, Jingwen Jiang, Canhua Huang
BRAF V600E attracts wide attention in the treatment of colorectal cancer (CRC) as stratifying and predicting a refractory classification of CRC. Recent evidence indicates that Wnt/β-catenin signaling is broadly activated and participates in the refractoriness of BRAF V600E CRC, but the underlying molecular mechanism needs to be elucidated. Here, heat shock 70 kDa protein 8 (HSPA8), an essential regulator in chaperone-mediated autophagy (CMA), is identified as a potential therapeutic target for advanced BRAF V600E CRC...
November 16, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)