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https://www.readbyqxmd.com/read/28634536/telavancin-a-novel-semisynthetic-lipoglycopeptide-agent-to-counter-the-challenge-of-resistant-gram-positive-pathogens
#1
REVIEW
Biswadeep Das, Chayna Sarkar, Debasmita Das, Amit Gupta, Arnav Kalra, Shubham Sahni
Telavancin (TD-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). The US Food and Drug Administration (USFDA) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria, including MRSA (S. aureus, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus anginosus group, or Enterococcus faecalis)...
March 2017: Therapeutic Advances in Infectious Disease
https://www.readbyqxmd.com/read/28629388/the-albumin-exendin-4-recombinant-protein-e2hsa-improves-glycemic-control-and-%C3%AE-cell-function-in-spontaneous-diabetic-kkay-mice
#2
Caina Li, Shaocong Hou, Shuainan Liu, Yi Huan, Sujuan Sun, Quan Liu, Zhufang Shen
BACKGROUND: E2HSA is a genetic fusion protein that consists of two tandem exendin-4 molecules that are covalently bonded to recombinant human serum albumin via a peptide linker. Previous studies have demonstrated that E2HSA significantly decreased blood glucose levels, improved β-cell function and promoted β-cell proliferation in diabetic db/dB mice. This study aimed to evaluate the benefits of E2HSA on glucose and lipid metabolism in a spontaneous diabetes animal model, KKAy mice. METHODS: E2HSA was acutely administered at doses of 1, 3 and 9 mg/kg by subcutaneous injection in diabetic KKAy mice with exendin-4 (2 μg/kg) as a positive reference, and then the non-fasting blood glucose and food intake levels were dynamically monitored...
June 19, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28626167/a-human-glucagon-like-peptide-1-albumin-recombinant-protein-with-prolonged-hypoglycemic-effect-provides-efficient-and-beneficial-control-of-glucose-metabolism-in-diabetic-mice
#3
Caina Li, Miaomiao Yang, Guojiang Hou, Shuainan Liu, Yi Huan, Dongan Yu, Sujuan Sun, Quan Liu, Shousheng Yan, Zhufang Shen
GW002 is a recombinant protein engineered by fusing the C-terminal region of human glucagon-like peptide-1 (GLP-1) to the N-terminal region of human serum albumin (HSA) with a peptide linker. This study aims to evaluate its anti-diabetic effects both in vitro and vivo. The GLP-1 receptor-dependent luciferase reporter plasmid was transiently transfected in NIT-1 cells to calculate the half-maximal concentration (EC50) for GLP-1 receptor activation, and normal ICR mice and diabetic KKAy mice were acutely injected with GW002 (1, 3 and 9 mg/kg) subcutaneously to evaluate the hypoglycemic action, while the diabetic KKAy and db/db mice were treated with GW002 once daily for 7 weeks to evaluate the effects on glucose metabolism...
June 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28623664/mechanosensory-neurons-control-the-timing-of-spinal-microcircuit-selection-during-locomotion
#4
Claire Wyart, Steven Knafo, Kevin Fidelin, Andrew Prendergast, Po-En Brian Tseng, Alexandre Parrin, Charles William Dickey, Urs Lucas Böhm, Sophie Nunes FIgueiredo, Olivier Thouvenin, Hugues Pascal-Moussellard
Despite numerous physiological studies about reflexes in the spinal cord, the contribution of mechanosensory feedback to active locomotion and the nature of underlying spinal circuits remains elusive. Here we investigate how mechanosensory feedback shapes active locomotion in a genetic model organism exhibiting simple locomotion-the zebrafish larva. We show that mechanosensory feedback enhances the recruitment of motor pools during active locomotion. Furthermore, we demonstrate that inputs from mechanosensory neurons increase locomotor speed by prolonging fast swimming at the expense of slow swimming during stereotyped acoustic escape responses...
June 17, 2017: ELife
https://www.readbyqxmd.com/read/28619366/bpi-3016-a-novel-long-acting-hglp-1-analogue-for-the-treatment-of-type-2-diabetes-mellitus
#5
Lieming Ding, Sisi Lu, Yanping Wang, Haibo Chen, Wei Long, Cunbo Ma, Erlong He, Dan Yan, Fenlai Tan
Glucagon-like peptide-1 (GLP-1) analogues have been commonly used as add-on medications for patients with Type 2 diabetes mellitus (T2DM). Currently, the development of long-acting GLP-1 analogues which allow the freedom and flexibility of once-weekly injections while maintaining their potency for a relatively long period has become the mainstream. Here, we successfully developed a long-acting human GLP-1(7-37) analogue (BPI-3016) with significantly extended half-life and increased resistance to dipeptidyl peptidase IV (DPP-IV) cleavage by structural modifications of human GLP-1...
June 13, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28618659/projected-impact-of-climate-change-and-chemical-emissions-on-the-water-quality-of-the-european-rivers-rhine-and-meuse-a-drinking-water-perspective
#6
Rosa M A Sjerps, Thomas L Ter Laak, Gertjan J J G Zwolsman
Low river discharges of the rivers Rhine and Meuse are expected to occur more often and more prolonged in a changing climate. During these dry periods the dilution of point sources such as sewage effluents is reduced leading to a decline in chemical water quality. This study projects chemical water quality of the rivers Rhine and Meuse in the year 2050, based on projections of chemical emissions and two climate scenarios: moderate and fast climate change. It focuses on specific compounds known to be relevant to drinking water production, i...
June 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28617863/the-use-of-metabolic-profiling-to-identify-insulin-resistance-in-veal-calves
#7
Andre J Pantophlet, Han Roelofsen, Marcel P de Vries, Walter J J Gerrits, Joost J G C van den Borne, Roel J Vonk
Heavy veal calves (4-6 months old) are at risk of developing insulin resistance and disturbed glucose homeostasis. Prolonged insulin resistance could lead to metabolic disorders and impaired growth performance. Recently, we discovered that heavy Holstein-Friesian calves raised on a high-lactose or high-fat diet did not differ in insulin sensitivity, that insulin sensitivity was low and 50% of the calves could be considered insulin resistant. Understanding the patho-physiological mechanisms underlying insulin resistance and discovering biomarkers for early diagnosis would be useful for developing prevention strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28611728/are-movement-artifacts-in-magnetic-resonance-imaging-a-real-problem-a-narrative-review
#8
REVIEW
Inger Havsteen, Anders Ohlhues, Kristoffer H Madsen, Janus Damm Nybing, Hanne Christensen, Anders Christensen
Movement artifacts compromise image quality and may interfere with interpretation, especially in magnetic resonance imaging (MRI) applications with low signal-to-noise ratio such as functional MRI or diffusion tensor imaging, and when imaging small lesions. High image resolution has high sensitivity to motion artifacts and often prolongs scan time that again aggravates movement artifacts. During the scan fast imaging techniques and sequences, optimal receiver coils, careful patient positioning, and instruction may minimize movement artifacts...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28611004/an-in-situ-forming-phospholipid-based-phase-transition-gel-prolongs-the-duration-of-local-anesthesia-for-ropivacaine-with-minimal-toxicity
#9
Hanmei Li, Tao Liu, Yuxuan Zhu, Qiang Fu, Wanxia Wu, Jie Deng, Li Lan, Sanjun Shi
An injectable, phospholipid-based phase transition gel (PPTG) has been developed for prolonging the release of ropivacaine (RO) for local anesthesia. PPTG was prepared by mixing phospholipids, medium-chain triglyceride and ethanol. Prior to injection, the PPTG is in a sol state with low viscosity. After subcutaneous injection, the PPTG rapidly forms a gel in situ, which acts as a drug release depot as verified by in vitro release profiles and in vivo pharmacokinetics. Administering RO-PPTG to rats led to a significantly smaller initial burst release than administering RO solution or RO base suspension...
June 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28608684/antioxidant-vitamin-e-cyclodextrin-inclusion-complex-electrospun-nanofibers-enhanced-water-solubility-prolonged-shelf-life-and-photostability-of-vitamin-e
#10
Asli Celebioglu, Tamer Uyar
Here, we demonstrated the electrospinning of polymer-free nanofibrous webs from inclusion complex (IC) between hydroxypropyl-β-cyclodextrin (HPβCD) and Vitamin E (Vitamin E/HPβCD-IC NF). The inclusion complexation between HPβCD and Vitamin E was prepared by using two different molar ratio (Vitamin E: HPβCD; 1:2 and 1:1), which correspond to theoretical value of ~13% (w/w) and 26% (w/w) loading of Vitamin E in the nanofiber (NF) matrix. After electrospinning and storage, a very high loading of Vitamin E (up to ~11% w/w, with respect to fiber matrix) was preserved in Vitamin E/HPβCD-IC NF...
June 13, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28594657/fitness-moderates-glycemic-responses-to-sitting-and-light-activity-breaks
#11
Matthew McCarthy, Charlotte L Edwardson, Melanie J Davies, Joseph Henson, Danielle H Bodicoat, Kamlesh Khunti, David W Dunstan, James A King, Thomas Yates
PURPOSE: This study aimed to experimentally determine whether cardio-respiratory fitness (CRF) modifies postprandial glycemia during prolonged sitting and investigated the potentially blunting influence this may have upon the benefits of interrupting postprandial sitting time with light activity breaks. METHODS: Thirty-four adults (18female; 16male; mean ± SD age: 40 ± 9years, BMI: 24.5 ± 3kg/m) undertook two 7·5hour experimental conditions in a randomized order: 1) Prolonged sitting; 2) Sitting interspersed with 5min light walking bouts every 30min...
June 8, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28589456/zn-2-sequestration-by-nostoc-muscorum-study-of-thermodynamics-equilibrium-isotherms-and-biosorption-parameters-for-the-metal
#12
Omega L Diengdoh, Mayashree B Syiem, Kannan Pakshirajan, Amar N Rai
Microbial biosorption has evolved as an effective strategy for heavy metal removal from contaminated waters. The common cyanobacterium Nostoc muscorum isolated from the banks of a polluted river in Meghalaya, India, was tested for its potential to remove Zn(2+) from aqueous solutions. Energy-dispersive X-ray (EDX) study verified Zn binding on the cyanobacterial biomass, and FTIR analysis revealed many negatively charged functional groups (hydroxyl, carbonyl, alcohol, amine, phosphoryl, sulfhydryl, and carboxyl) on the cell surface that aided in metal binding...
July 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28588788/survival-of-patients-with-lung-cancer-and-diabetes-mellitus
#13
Koichi Kurishima, Hiroko Watanabe, Hiroichi Ishikawa, Hiroaki Satoh, Nobuyuki Hizawa
Diabetes mellitus (DM) and lung cancer are two highly globally prevalent diseases. The current study aimed to determine the prognostic significance of DM comorbidity in patients with lung cancer. All patients diagnosed at Tsukuba Medical Center Hospital and Mito Medical Center, (University of Tsukuba, Ibaraki, Japan) between April 1999 and March 2012 were followed up to 2015 and were retrospectively analyzed. DM was defined as a fasting plasma glucose (FPG) level ≥126 mg/dl, a non-FPG level ≥200 mg/dl, or a hemoglobin (Hb) A1c level ≥6...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28588499/intake-of-a-ketone-ester-drink-during-recovery-from-exercise-promotes-mtorc1-signaling-but-not-glycogen-resynthesis-in-human-muscle
#14
Tijs Vandoorne, Stefan De Smet, Monique Ramaekers, Ruud Van Thienen, Katrien De Bock, Kieran Clarke, Peter Hespel
Purpose: Ketone bodies are energy substrates produced by the liver during prolonged fasting or low-carbohydrate diet. The ingestion of a ketone ester (KE) rapidly increases blood ketone levels independent of nutritional status. KE has recently been shown to improve exercise performance, but whether it can also promote post-exercise muscle protein or glycogen synthesis is unknown. Methods: Eight healthy trained males participated in a randomized double-blind placebo-controlled crossover study. In each session, subjects undertook a bout of intense one-leg glycogen-depleting exercise followed by a 5-h recovery period during which they ingested a protein/carbohydrate mixture...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28584055/prolonged-fasting-suppresses-mitochondrial-nlrp3-inflammasome-assembly-and-activation-via-sirt3-mediated-activation-of-superoxide-dismutase-2
#15
Javier Traba, Sarah S Geiger, Miriam Kwarteng Siaw, Kim Han, One Hyuk Ra, Richard M Siegel, David Gius, Michael N Sack
Twenty-four hours of fasting is known to blunt activation of the human NLRP3 inflammasome. This effect might be mediated by SIRT3 activation, controlling mitochondrial reactive oxygen species (ROS). To characterize the molecular underpinnings of this fasting effect, we comparatively analyzed the NLRP3 inflammasome response to nutrient deprivation in wildtype and SIRT3-knockout mice. Consistent with previous findings for human NLRP3, prolonged fasting blunted the inflammasome in wildtype mice but not in SIRT3-knockout mice...
June 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28578285/bioinspired-catecholic-activation-of-marine-chitin-for-immobilization-of-ag-nanoparticles-as-recyclable-pollutant-nanocatalysts
#16
Yanwei Wang, Qingshan Kong, Beibei Ding, Yijun Chen, Xiaofei Yan, Shiwei Wang, Fushan Chen, Jun You, Chaoxu Li
Being one type of the most abundant marine polysaccharides in nature, chitin has inert chemical properties and thus prolonged been hindered for high-value utilization. A mussel-inspired catecholic chemistry was found to be able to confer nature-derived mesoporous chitin aerogels with high and tunable surface activities. When further combining with their high porosity, high specific surface area, mechanical toughness and unique nanofibrous architecture, these catechol-activated chitin aerogels could be used as a unique supporting matrix to immobilize Ag nanoparticles...
May 26, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28577886/investigating-physiological-glucose-excursions-before-during-and-after-ramadan-in-adults-without-diabetes-mellitus
#17
Maria Pallayova, Hadeel B Zaghloul, Teresa Arora, Sopna M Choudhury, Omar M Omar, Odette L Chagoury, Shahrad Taheri
AIM: The study aimed to investigate physiological effects of Ramadan fasting on continuously monitored glucose levels in relation to Ramadan in young non-diabetic adults. METHODS: Continuous glucose monitoring was employed to measure interstitial glucose for several days 1-2weeks before Ramadan, in the middle of Ramadan, and 4-6weeks after Ramadan to assess glucose exposure and glucose variability. RESULTS: A total of 34,182 accurate glucose sensor readings and 438 capillary blood glucose values [mean absolute difference median (interquartile range) 8...
May 31, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28574286/changes-of-intima-media-thickness-in-marathon-runners-a-mid-term-follow-up
#18
Jan Müller, Valeria Dahm, Elke S Lorenz, Axel Pressler, Bernhard Haller, Viola Grabs, Martin Halle, Johannes Scherr
Objective Carotid intima-media thickness (IMT) is used to assess cardiovascular risk and progression of atherosclerosis. It is known that regular physical activity of moderate intensity has beneficial effects on the vasculature. However, it is still discussed controversially whether prolonged exercise, including participation in exhaustive competitive sports such as long-distance races, has also beneficial effects or might even be harmful regarding the cardiovascular system. Patients and methods Thirty-eight male marathon runners (45...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28570377/part-i-the-effects-of-music-for-the-symptom-management-of-anxiety-pain-and-insomnia-in-critically-ill-patients-an-integrative-review-of-current-literature
#19
Naheed Meghani, Mary Fran Tracy, Niloufar Niakosari Hadidi, Ruth Lindquist
Critical care environments are known for provoking anxiety, pain, and sleeplessness. Often, these symptoms are attributed to patients' underlying physiological conditions; life-sustaining or life-prolonging treatments such as ventilators, invasive procedures, tubes, and monitoring lines; and noise and the fast-paced technological nature of the critical care environment. This, in turn, possibly increases length of stay and morbidity and challenges the recovery and healing of critically ill patients. Complementary therapies can be used as adjunctive therapies alongside pharmacological interventions and modalities...
July 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28555777/early-ictal-and-interictal-patterns-in-fires-the-sparks-before-the-blaze
#20
Raquel Farias-Moeller, Luca Bartolini, Katelyn Staso, John M Schreiber, Jessica L Carpenter
OBJECTIVE: Febrile infection-related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy described as explosive onset of super refractory status epilepticus (SRSE) in previously healthy children. We describe electroencephalography (EEG) abnormalities in the hyperacute phase of FIRES, with the aim of contributing to the diagnostic characterization of a syndrome otherwise lacking specific biomarkers. METHODS: This is a retrospective single-center, case series of seven children with FIRES...
May 26, 2017: Epilepsia
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