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https://www.readbyqxmd.com/read/29149460/the-impact-of-a-prolonged-stay-in-the-icu-on-patients-fundamental-care-needs
#1
Claire Minton, Lesley Batten, Annette Huntington
AIM: To explore patients', families', and health professionals' experiences of a long-stay patient in an intensive care unit. BACKGROUND: The fast-paced technologically driven intensive care unit environment, designed for a short patient stay, supports the provision of complex physiologically-focused care for those with life-threatening illnesses. Long stay patients with pronounced fundamental care needs fall outside predicted patient pathways, and nurses can find caring for these patients challenging...
November 17, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29147968/effects-of-fasting-on-the-activities-and-mrna-expression-levels-of-lipoprotein-lipase-lpl-hormone-sensitive-lipase-hsl-and-fatty-acid-synthetase-fas-in-spotted-seabass-lateolabrax-maculatus
#2
Hongli Huang, Yu Zhang, Mingyue Cao, Liangyi Xue, Weiliang Shen
To investigate the effects of fasting on lipid metabolism in spotted seabass muscle and liver tissues, we analyzed mRNA levels and enzyme activities of lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and fatty acid synthetase (FAS), and the relationship among fat content, mRNA level, and enzyme activity during fasting of 35 days. The results showed that expressions of all the three genes were ubiquitous. During the fasting experiment, the hepatosomatic index (HSI) and fat content of muscle and liver tissues significantly decreased before 5 days of fasting (P < 0...
November 16, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29140685/heterogeneous-ti3sic2-c-containing-na2ti7o15-architecture-for-high-performance-sodium-storage-at-elevated-temperatures
#3
Guodong Zou, Qingrui Zhang, Carlos Fernandez, Gang Huang, Jianyu Huang, Qiuming Peng
Rational design of heterogeneous electrode materials with hierarchical architecture is a potential approach to significantly improve their energy densities. Herein, we report a tailored microwave-assisted synthetic strategy to create heterogeneous hierarchical Ti3SiC2@C-containing Na2Ti7O15 (MAX@C-NTO) composites as potential anode materials for high-performance sodium storage in a wide temperature range from 25 to 80 °C. This composite delivers first reversible capacities of 230 mAh g(-1) at 200 mA g(-1) and 149 mAh g(-1) at 3000 mA g(-1) at 25 °C...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29131415/superior-toughness-and-fast-self-healing-at-room-temperature-engineered-by-transparent-elastomers
#4
Seon-Mi Kim, Hyeonyeol Jeon, Sung-Ho Shin, Seul-A Park, Jonggeon Jegal, Sung Yeon Hwang, Dongyeop X Oh, Jeyoung Park
The most important properties of self-healing polymers are efficient recovery at room temperature and prolonged durability. However, these two characteristics are contradictory, making it difficult to optimize them simultaneously. Herein, a transparent and easily processable thermoplastic polyurethane (TPU) with the highest reported tensile strength and toughness (6.8 MPa and 26.9 MJ m(-3) , respectively) is prepared. This TPU is superior to reported contemporary room-temperature self-healable materials and conveniently heals within 2 h through facile aromatic disulfide metathesis engineered by hard segment embedded aromatic disulfides...
November 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29129696/the-making-of-a-mushroom-mitosis-nuclear-migration-and-the-actin-network
#5
Elke-Martina Jung, Erika Kothe, Marjatta Raudaskoski
Basidiomycetes feature a prolonged dikaryotic life stage. A dispute over open versus closed mitosis could be solved using in vivo fluorescence videomicroscopy of histone 2B::EGFP and Lifeact labeled Schizophyllum commune. It revealed nuclei to condense to approximately one fifth in diameter during mitotic prophase. In addition, the specifics of clamp cell formation typical of many basidiomycetes included an actin network at the future site of nuclear division, which allowed for cessation of nuclear movement and re-localization of one nucleus towards the emerging clamp cell, while the other divided along the hyphal axis...
November 9, 2017: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29128523/acute-effect-of-smoking-and-smoking-abstinence-on-energy-intake-and-appetite-related-hormones-blood-concentrations
#6
M Yannakoulia, C A Anastasiou, K Zachari, M Sidiropoulou, P Katsaounou, R Tenta
The effect of smoking on energy balance and the underlying mechanisms are not fully understood. The aim of the present study is to examine the acute effect of smoking and its abstinence on energy intake, subjective feelings of appetite and related hormones. Fourteen healthy smokers participated in a randomized, crossover study consisting of two trials: the Cigarette trial (participants smoked two cigarettes of their brand within 15min) and the Sham trial (they were asked to hold the cigarette as smoking, but without lighting it)...
November 8, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29124978/sustained-release-solid-dispersion-of-pelubiprofen-using-the-blended-mixture-of-aminoclay-and-ph-independent-polymers-preparation-and-in-vitro-in-vivo-characterization
#7
Yeo-Song Lee, Jae Guen Song, Sang Hoon Lee, Hyo-Kyung Han
The present study aimed to develop the sustained-release oral dosage form of pelubiprofen (PEL) by using the blended mixture of 3-aminopropyl functionalized-magnesium phyllosilicate (aminoclay) and pH-independent polymers. The sustained-release solid dispersion (SRSD) was prepared by the solvent evaporation method and the optimal composition of SRSD was determined as the weight ratio of drug: Eudragit® RL PO: Eudragit® RS PO of 1:1:2 in the presence of 1% of aminoclay (SRSD(F6)). The dissolution profiles of SRSD(F6) were examined at different pHs and in the simulated intestinal fluids...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29124365/change-in-reimbursement-and-costs-in-german-oncological-head-and-neck-surgery-over-the-last-decade-ablative-tongue-cancer-surgery-and-reconstruction-with-split-thickness-skin-graft-vs-microvascular-radial-forearm-flap
#8
Sebastian Hoefert, Oliver Lotter
OBJECTIVES: Defects after ablative tongue cancer surgery can be reconstructed by split-thickness skin grafts or free microvascular flaps. The different surgical options may influence costs, reimbursement, and therefore possible profits. Our goal was to analyze the development of these parameters for different procedures in head and neck reconstruction in Germany over the last decade. MATERIALS AND METHODS: After tumor resection and neck dissection of tongue cancer, three different scenarios were chosen to calculate costs, reimbursement, length of stay (LoS), and profits...
November 9, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29122559/constant-hepatic-atp-concentrations-during-prolonged-fasting-and-absence-of-effects-of-cerbomed-nemos-%C3%A2-on-parasympathetic-tone-and-hepatic-energy-metabolism
#9
Sofiya Gancheva, Alessandra Bierwagen, Daniel F Markgraf, Gidon J Bönhof, Kevin G Murphy, Erifili Hatziagelaki, Jesper Lundbom, Dan Ziegler, Michael Roden
OBJECTIVE: Brain insulin-induced improvement in glucose homeostasis has been proposed to be mediated by the parasympathetic nervous system. Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) activating afferent branches of the vagus nerve may prevent hyperglycemia in diabetes models. We examined the effects of 14-min taVNS vs sham stimulation by Cerbomed Nemos(®) on glucose metabolism, lipids, and hepatic energy homeostasis in fasted healthy humans (n = 10, age 51 ± 6 yrs, BMI 25...
October 25, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29114500/analysis-of-energy-restriction-and-physical-activity-on-brain-function-the-role-of-ketone-body-and-brain-derived-neurotrophic-factor
#10
REVIEW
Chan Ho Park, Yi-Sub Kwak
Brain development is a complex process, and stimuli during this development period may modulate the functional maturation of the brain. It has been shown that environmental stimuli, such as physical activity habits, have a beneficial effect on brain development. Endurance exercise and prolonged fasting state are known to improve brain function including cognition. The exact mechanisms of exercise improving brain function are still unknown. However, it can be considered that energy restriction and stressful challenge induced by long-lasting physical exercise might cause direct effect on brain function...
August 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/29113829/increased-motor-neuron-resilience-by-small-molecule-compound-that-regulate-igf-ii-expression
#11
Teresia M Osborn, Jonathan Beagan, Ole Isacson
The selective vulnerability of motor neurons in amyotrophic lateral sclerosis (ALS) is evident by sparing of a few subpopulations during this fast progressing and debilitating degenerative disease. By studying the gene expression profile of resilient vs. vulnerable motor neuron populations we can gain insight in what biomolecules and pathways may contribute to the resilience and vulnerability. Several genes have been found to be differentially expressed in the vulnerable motor neurons of the cervical spinal cord as compared to the spared motor neurons in CN3/4...
November 4, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29112362/performance-and-reliability-of-electrowetting-on-dielectric-ewod-systems-based-on-tantalum-oxide
#12
Marcel Mibus, Giovanni Zangari
The electrowetting-on-dielectric behavior of Cytop/Tantalum oxide (TaOx) bilayers is studied by measuring their response vs applied voltage and under prolonged periodic cycling, below and above the threshold voltage VT corresponding to the breakdown field for the oxide. TaOx exhibits symmetric solid state I-V characteristics, with electronic conduction dominated by Schottky, Poole-Frenkel emission; conduction is attributed to oxygen vacancies (6 × 10(16) cm(-3)), resulting in large currents at low bias. Electrolyte/Metal Oxide/Metal I-V characteristics show oxide degradation at (<5 V) cathodic bias; anodic bias in contrast results in stable characteristics until reaching the anodization voltage, where the oxide thickens, leading eventually to breakdown and oxygen production at the electrode...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29110954/effect-of-motor-subtypes-of-delirium-in-the-intensive-care-unit-on-fast-track-failure-after-cardiac-surgery
#13
Anna Lee, Jing Lan Mu, Chun Hung Chiu, Tony Gin, Malcolm John Underwood, Gavin Matthew Joynt
OBJECTIVE: The purpose of the study was to evaluate the association between motor subtypes of postoperative delirium in the intensive care unit and fast-track failure (a composite outcome of prolonged stay in the intensive care unit >48 hours, intensive care unit readmission, and 30-day mortality) after cardiac surgery. METHODS: This was a secondary analysis of a prospective cohort study of 600 consecutive adults undergoing cardiac surgery at a university hospital in Hong Kong (July 2013 to July 2015)...
September 30, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29105987/a-ketone-ester-drink-lowers-human-ghrelin-and-appetite
#14
Brianna J Stubbs, Pete J Cox, Rhys D Evans, Malgorzata Cyranka, Kieran Clarke, Heidi de Wet
OBJECTIVE: The ketones d-β-hydroxybutyrate (BHB) and acetoacetate are elevated during prolonged fasting or during a "ketogenic" diet. Although weight loss on a ketogenic diet may be associated with decreased appetite and altered gut hormone levels, it is unknown whether such changes are caused by elevated blood ketones. This study investigated the effects of an exogenous ketone ester (KE) on appetite. METHODS: Following an overnight fast, subjects with normal weight (n = 15) consumed 1...
November 6, 2017: Obesity
https://www.readbyqxmd.com/read/29102970/cabergoline-induced-fibrosis-of-prolactinomas-a-neurosurgical-perspective
#15
Niraj Mohan, Yi Yan Chia, Giap Hean Goh, Eric Ting, Kejia Teo, Tseng Tsai Yeo
Presently, the standard of care for prolactinomas, a type of pituitary adenoma, is dopaminergic agents such as bromocriptine and cabergoline. However, dopaminergic agents may induce fibrosis of cardiac valves leading to valvular insufficiency, necessitating surgical treatment of prolactinoma. Fibrosis of prolactinoma can be induced by prolonged medical treatment with bromocriptine, and this usually occurs after years of treatment. In comparison to bromocriptine, there have been no reports of cabergoline-induced fibrosis of prolactinoma...
November 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29101564/first-experience-with-the-autolap%C3%A2-system-an-image-based-robotic-camera-steering-device
#16
Paul J M Wijsman, Ivo A M J Broeders, Hylke J Brenkman, Amir Szold, Antonello Forgione, Henk W R Schreuder, Esther C J Consten, Werner A Draaisma, Paul M Verheijen, Jelle P Ruurda, Yuval Kaufman
BACKGROUND: Robotic camera holders for endoscopic surgery have been available for 20 years but market penetration is low. The current camera holders are controlled by voice, joystick, eyeball tracking, or head movements, and this type of steering has proven to be successful but excessive disturbance of surgical workflow has blocked widespread introduction. The Autolap™ system (MST, Israel) uses a radically different steering concept based on image analysis. This may improve acceptance by smooth, interactive, and fast steering...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29101523/functional-comparison-of-corticostriatal-and-thalamostriatal-postsynaptic-responses-in-striatal-neurons-of-the-mouse
#17
M A Arias-García, D Tapia, J A Laville, V M Calderón, Y Ramiro-Cortés, J Bargas, E Galarraga
Synaptic inputs from cortex and thalamus were compared in electrophysiologically defined striatal cell classes: direct and indirect pathways' striatal projection neurons (dSPNs and iSPNs), fast-spiking interneurons (FS), cholinergic interneurons (ChINs), and low-threshold spiking-like (LTS-like) interneurons. Our purpose was to observe whether stimulus from cortex or thalamus had equivalent synaptic strength to evoke prolonged suprathreshold synaptic responses in these neuron classes. Subthreshold responses showed that inputs from either source functionally mix up in their dendrites at similar electrotonic distances from their somata...
November 3, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/29099601/interactions-between-chloramphenicol-carrier-polymers-and-bacteria-implications-for-designing-electrospun-drug-delivery-systems-countering-wound-infection
#18
Liis Preem, Mohammad Mahmoudzadeh, Marta Putrinš, Andres Meos, Ivo Laidmäe, Tavo Romann, Jaan Aruväli, Riinu Härmas, Artturi Koivuniemi, Alex Bunker, Tanel Tenson, Karin Kogermann
Antibacterial drug-loaded electrospun nano- and microfibrous dressings are of major interest as novel topical drug delivery systems in wound care. In this study, chloramphenicol (CAM)-loaded polycaprolactone (PCL) and PCL/poly(ethylene oxide) (PEO) fiber mats were electrospun and characterized in terms of morphology, drug distribution, physicochemical properties, drug release, swelling, cytotoxicity, and antibacterial activity. Computational modeling together with physicochemical analysis helped to elucidate possible interactions between the drug and carrier polymers...
November 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29092729/bioequivalence-and-food-effect-study-of-two-zaltoprofen-preparations-in-healthy-chinese-volunteers%C3%A2
#19
Ying Song, Yi Ding, Yanyan Jia, Jinyi Zhao, Kai Gao, Chengtao Lu, Ruili Li, Aidong Wen
OBJECTIVE: Zaltoprofen, a propionic acid derivative of nonsteroidal anti-inflammatory drug (NSAID), has powerful anti-inflammatory and analgesic effects on inflammatory pain. This study was undertaken to investigate the effect of food on the pharmacokinetic parameters of zaltoprofen capsule (trial preparation, T) and tablet (reference preparation, R), and to assess the relative bioequivalence of two zaltoprofen preparations. MATERIALS AND METHODS: In this open-label, randomized, crossover, two-state, four-period study, 24 healthy Chinese volunteers were randomized to receive a single oral dose of zaltoprofen capsule/tablet (80 mg) under fasting and fed state...
October 26, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29090223/paraoxonase-1-activity-lipid-profile-and-atherogenic-indexes-status-in-coronary-heart-disease
#20
Mostafa Cheraghi, Gholamreza Shahsavari, Ali Maleki, Hassan Ahmadvand
BACKGROUND: Dyslipidemia is considered an independent risk factor for coronary heart disease (CHD). In the present study, we examined lipid profiles and paraoxonase 1 (PON1) activity and atherogenic indexes status and the relationship of PON1 activity by high-density lipoprotein (HDL) and atherogenic indexes in CHD patients and healthy people. METHODS: The aim of the study was to compare PON1, lipid profiles, and atherogenic indexes in CHD patients and healthy people as controls...
October 2017: Reports of Biochemistry & Molecular Biology
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