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https://www.readbyqxmd.com/read/29145926/corrigendum-to-increased-high-molecular-weight-adiponectin-but-decreased-total-adiponectin-and-kisspeptin-in-central-precocious-puberty-compared-with-aged-matched-prepubertal-girls
#1
Chantacha Sitticharoon, Maynart Sukharomana, Supawadee Likitmaskul, Malika Churintaraphan, Pailin Maikaew
The aim of the present study was to compare serum leptin, kisspeptin, total adiponectin, high molecular weight (HMW) adiponectin and neuropeptide Y (NPY) levels between girls with central precocious puberty (CPP; n=26, 7-9.5 years old) and age-matched controls (n=29) including or excluding obese girls. Leptin and NPY levels were comparable between CPP and control girls. Kisspeptin levels were lower in the CPP than control group, and were positively correlated with oestrogen in the control group and with systolic and diastolic blood pressure in the CPP group...
November 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29145598/pubertal-escape-from-estradiol-negative-feedback-in-ewe-lambs-is-not-accounted-for-by-decreased-esr1-mrna-or-protein-in-kisspeptin-neurons
#2
Michelle N Bedenbaugh, Marcella D'Oliveira, Rodolfo C Cardoso, Stanley M Hileman, Gary L Williams, Marcel Amstalden
In this study, we investigated whether decreased sensitivity to estradiol negative feedback is associated with reduced ESR1 expression in kisspeptin neurons as ewe lambs approach puberty. Lambs were ovariectomized and received no implant (OVX) or an implant containing estradiol (OVX+E). In the middle arcuate nucleus (mARC), ESR1 mRNA was greater in OVX than OVX+E lambs but did not differ elsewhere. Posthoc analysis of LH secretion from OVX+E lambs revealed three patterns of LH pulsatility: low (1-2 pulses/12 h; LF, n=3), moderate (6-7 pulses/12 h; MF, n=6) and high (>10 pulses/12 h; HF, n=5)...
November 14, 2017: Endocrinology
https://www.readbyqxmd.com/read/29137471/serum-levels-of-spexin-and-kisspeptin-negatively-correlate-with-obesity-and-insulin-resistance-in-women
#3
P A Kołodziejskii, E Pruszyńska-Oszmałek, E Korek, M Sassek, D Szczepankiewicz, P Kaczmarek, L Nogowski, P Maćkowiak, K W Nowak, H Krauss, M Z Strowski
Spexin (SPX) and kisspeptin (KISS) are novel peptides relevant in the context of regulation of metabolism, food intake, puberty and reproduction. Here, we studied changes of serum SPX and KISS levels in female non-obese volunteers (BMI<25 kg/m2) and obese patients (BMI>35 kg/m2). Correlations between SPX or KISS with BMI, McAuley index, QUICKI, HOMA IR, serum levels of insulin, glucagon, leptin, adiponectin, orexin-A, obestatin, ghrelin and GLP-1 were assessed. Obese patients had lower SPX and KISS levels as compared to non-obese volunteers (SPX: 4...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29136398/molecular-cloning-and-epigenetic-change-detection-of-kiss1-during-seasonal-reproduction-in-chinese-indigenous-sheep
#4
Xiaoyun He, Qiuyue Liu, Xiaoyu Li, Xiaofei Guo, Xiangyu Wang, Wenping Hu, Ran Di, Mingxing Chu
Like most seasonal domesticated species, sheep are short-day breeders, which means that the reproduction axis is activated by short days. The annual photoperiodic cycle affects the amount of daylength information that is transmitted to the hypothalamic-pituitary-gonadal (HPG) axis by regulating pulsatile secretion of gonadotrophin-releasing hormone from the hypothalamus. Kisspeptin, which is encoded by Kiss1, plays a major role in reproductive seasonality. Based on results from our previous Solexa sequencing data obtained from Tan (T) and Small Tail Han (STH) sheep during anoestrus and the breeding season, full-length mRNA information for ovine Kiss1 was obtained; 894bp in T sheep and 1145bp in STH sheep...
November 15, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29129377/kisspeptin-as-a-biomarker-for-miscarriage-let-s-wait
#5
EDITORIAL
Ricardo F Savaris
No abstract text is available yet for this article.
November 9, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29126131/continuous-kisspeptin-restores-luteinizing-hormone-pulsatility-following-cessation-by-a-neurokinin-b-antagonist-in-female-sheep
#6
Iain J Clarke, Qun Li, Belinda A Henry, Robert P Millar
Pulsatile secretion of gonadotropin releasing hormone (GnRH) drives pulsatile secretion of luteinizing hormone (LH), with evidence that this depends upon kisspeptin (Kiss) input to GnRH neurons. Kiss administration causes acute GnRH/LH secretion and electrophysiological data suggest that Kiss neurons may act in a phasic manner to drive GnRH secretion, but there is not definitive evidence for this. The product of the Kiss1 gene is proteolytically cleaved to smaller products and the 10 amino-acid C-terminal product (Kiss-10) displays full bioactivity...
November 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/29114074/glutamatergic-transmission-to-hypothalamic-kisspeptin-neurons-is-differentially-regulated-by-estradiol-through-estrogen-receptor-%C3%AE-in-adult-female-mice
#7
Luhong Wang, Laura L Burger, Megan L Greenwald-Yarnell, Martin G Myers, Suzanne M Moenter
Estradiol feedback regulates gonadotropin-releasing hormone (GnRH) neurons and subsequent luteinizing hormone (LH) release. Estradiol acts through estrogen receptor α (ERα)-expressing afferents of GnRH neurons including kisspeptin neurons in the anteroventral periventricular (AVPV) and arcuate nuclei, providing homeostatic feedback on episodic GnRH/LH release as well as positive feedback to control ovulation. Ionotropic glutamate receptors are important for estradiol feedback but it is not known where they fit in the circuitry...
November 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29109352/mapping-of-kndy-neurons-and-immunohistochemical-analysis-of-the-interaction-between-kndy-and-substance-p-neural-systems-in-goat
#8
Hiroaki Okamura, Takashi Yamamura, Yoshihiro Wakabayashi
A population of neurons in the arcuate nucleus (ARC) coexpresses kisspeptin, neurokinin B (NKB), and dynorphin, and therefore they are referred to as KNDy neurons. It has been suggested that KNDy neurons participate in several brain functions, including the control of reproduction. The present study aimed to advance our understanding of the anatomy of the KNDy neural system. We first produced an antiserum against goat kisspeptin. After confirming its specificity, the antiserum was used to histochemically detect kisspeptin-positive signals...
November 7, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/29109258/definition-of-the-hypothalamic-gnrh-pulse-generator-in-mice
#9
Jenny Clarkson, Su Young Han, Richard Piet, Timothy McLennan, Grace M Kane, Jamie Ng, Robert W Porteous, Joon S Kim, William H Colledge, Karl J Iremonger, Allan E Herbison
The pulsatile release of luteinizing hormone (LH) is critical for mammalian fertility. However, despite several decades of investigation, the identity of the neuronal network generating pulsatile reproductive hormone secretion remains unproven. We use here a variety of optogenetic approaches in freely behaving mice to evaluate the role of the arcuate nucleus kisspeptin (ARN(KISS)) neurons in LH pulse generation. Using GCaMP6 fiber photometry, we find that the ARN(KISS) neuron population exhibits brief (∼1 min) synchronized episodes of calcium activity occurring as frequently as every 9 min in gonadectomized mice...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29100632/the-anti-estrogenicity-of-chronic-exposure-to-semicarbazide-in-female-japanese-flounders-paralichthys-olivaceus-and-its-potential-mechanisms
#10
Zonghao Yue, Miao Yu, Haifeng Zhao, Jun Wang, Xiaona Zhang, Hua Tian, Wei Wang, Shaoguo Ru
This study investigated the anti-estrogenic effects of chronic exposure to a new marine pollutant, semicarbazide (SMC; 1, 10, and 100μg/L), in female Paralichthys olivaceus, as well as the associated mechanism. After 130days of exposure, plasma 17β-estradiol and testosterone concentrations, and hepatic estrogen receptors, vitellogenin, and choriogenin mRNA levels decreased significantly in SMC-exposed groups. Moreover, down-regulation of genes in the hypothalamic-pituitary-gonadal axis, including gonadotropin-releasing hormone, gonadotropic hormones and their receptors, the steroidogenic acute regulatory protein, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase, and cytochrome P450 19A, was observed after SMC exposure...
October 31, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29097006/kisspeptin-recombinant-oral-vaccine-a-master-gene-vaccine-inhibiting-the-reproductive-physiology-and-behavior-of-ram-lambs
#11
Birhanu Tesema, Jia-Yu Zhao, Xun-Pin Jiang, Gui-Qiang Liu, Yan-Guo Han, Teketay Wassie
The KISS1 gene product, kisspeptin, stimulates gonadotrophic steroid hormone (GNRH) neuronal signaling through the G-protein coupled receptor, kiss1r. Disturbance of this signaling pathway causes hypogonadotropic hypogonadism in mammals. As part of this cutting-edge research project, we analyzed the efficacy of an oral kisspeptin recombinant vaccine on the reproductive physiology and behavior of ram lambs. Ten 56-day old ram lambs were randomly divided into treatment and control groups to receive the experimental recombinant vaccines, C500/pKS-asd or C500/pVAX-asd (aspartate-β semialdehyde dehydrogenase), respectively...
October 31, 2017: Vaccine
https://www.readbyqxmd.com/read/29072778/regulation-of-kisspeptin-synthesis-and-release-in-the-preoptic-anterior-hypothalamic-region-of-prepubertal-female-rats-actions-of-igf-1-and-alcohol
#12
Jill K Hiney, Vinod K Srivastava, Danielle N Vaden Anderson, Nicole L Hartzoge, William L Dees
Alcohol (ALC) causes suppressed secretion of prepubertal luteinizing hormone-releasing hormone (LHRH). Insulin-like growth factor-1 (IGF-1) and kisspeptin (Kp) are major regulators of LHRH and are critical for puberty. IGF-1 may be an upstream mediator of Kp in the preoptic area and rostral hypothalamic area (POA/RHA) of the rat brain, a region containing both Kp and LHRH neurons. We investigated the ability of IGF-1 to stimulate prepubertal Kp synthesis and release in POA/RHA, and the potential inhibitory effects of ALC METHODS: Immature female rats were administered either ALC (3g/Kg) or water via gastric gavage at 0730 h...
October 26, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29069289/distinct-dynorphin-expression-patterns-with-low-and-high-dose-estrogen-treatment-in-the-arcuate-nucleus-of-female-rats
#13
Moeko Kanaya, Kinuyo Iwata, Hitoshi Ozawa
Kisspeptin (KISS1; encoded by Kiss1 ) neurons in the arcuate nucleus (ARC) co-express tachykinin 3 (TAC3; also known as neurokinin B) and dynorphin A (PDYN). Accordingly, they are termed KNDy neurons and considered to be crucial in generating pulsatile release of gonadotropin-releasing hormone. Accumulating evidence suggests that Kiss1 and Tac3 are negatively regulated by estrogen. However it has not been fully determined whether and how estrogen modulates Pdyn and PDYN. Here, we examined the expression of Pdyn mRNA and PDYN by in situ hybridization and immunohistochemistry, respectively, in the ARC of female rats after ovariectomy (OVX) and OVX plus low or high-dose beta-estradiol (E 2 ) replacement...
October 24, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29053844/evolutionally-conserved-function-of-kisspeptin-neuronal-system-is-non-reproductive-regulation-as-revealed-by-non-mammalian-study
#14
Mikoto Nakajo, Shinji Kanda, Tomomi Karigo, Akiko Takahashi, Yasuhisa Akazome, Yoshihisa Uenoyama, Makito Kobayashi, Yoshitaka Oka
Kisspeptin neuronal system, which consists of a neuropeptide kisspeptin and its receptor Gpr54, is considered in mammals a key factor of reproductive regulation, so called hypothalamic-pituitary-gonadal (HPG) axis. However, in non-mammalian vertebrates, especially in teleosts, existence of kisspeptin regulation on HPG axis is still controversial. Here, we applied multidisciplinary techniques to a teleost fish, medaka and examined possible kisspeptin regulation on HPG axis. First, we generated knockout medaka for kisspeptin-related genes and found that they show normal fertility, gonadal maturation, and expression of gonadotropins...
October 18, 2017: Endocrinology
https://www.readbyqxmd.com/read/29044434/glp-1-increases-kiss-1-mrna-expression-in-kisspeptin-expressing-neuronal-cells
#15
Aki Oride, Haruhiko Kanasaki, Tselmeg Mijiddorj, Unurjargal Sukhbaatar, Tomomi Hara, Tuvshintugs Tumurbaatar, Satoru Kyo
Feeding-related metabolic factors exert regulatory influences on the hypothalamic-pituitary-gonadal axis. Glucagon-like peptide-1 (GLP-1) is an anorexigenic hormone synthesized from the ileum in response to food intake. The purpose of this study was to examine the direct effect of GLP-1 on hypothalamic kisspeptin and gonadotropin-releasing hormone (GnRH) expression using the rat clonal hypothalamic cell line rHypoE-8. GLP-1 significantly increased Kiss-1 mRNA expression in rHypoE-8 cells up to 1.94 ± 0.22-fold...
August 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29039178/-potential-clinical-application-of-kisspeptin-in-reproductive-endocrinology
#16
Yanling Fu, Yimin Zhu
Gonadotropin-releasing hormone (GnRH) plays an important role in the process of reproduction. Studies have shown that a family of peptides Kisspeptin can act on GnRH-related neurons, stimulating the secretion of GnRH, and activating the hypothalamic-pituitary-gonadal axis. Both animal experiments and clinical studies have shown that exogenous administration of Kisspeptin is able to induce physiological GnRH release in healthy individuals and those with endocrine-disorders, which brings great hope for treatment of reproductive endocrine diseases...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29024132/expression-of-isotocin-is-male-specifically-upregulated-by-gonadal-androgen-in-the-medaka-brain
#17
Junpei Yamashita, Yukika Kawabata, Kataaki Okubo
Oxytocin, a mammalian neuropeptide primarily synthesized in the supraoptic and paraventricular nuclei of the hypothalamus, mediates a variety of physiological and behavioral processes ranging from parturition and lactation to affiliation and prosociality. Multiple studies in rodents have shown that the expression of the oxytocin gene (Oxt) is stimulated by estrogen, while androgen has no apparent effect. However, this finding is not consistent across all studies, and no study has examined sex steroid regulation of Oxt or its orthologs in other animals...
October 10, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29019791/the-influence-of-dopaminergic-system-inhibition-on-biosynthesis-of-gonadotrophin-releasing-hormone-gnrh-and-gnrh-receptor-in-anoestrous-sheep-hierarchical-role-of-kisspeptin-and-rfamide-related-peptide-3-rfrp-3
#18
M Ciechanowska, M Łapot, E Paruszewska, W Radawiec, F Przekop
This study aimed to explain how prolonged inhibition of central dopaminergic activity affects the cellular processes governing gonadotrophin-releasing hormone (GnRH) and LH secretion in anoestrous sheep. For this purpose, the study included two experimental approaches: first, we investigated the effect of infusion of sulpiride, a dopaminergic D2 receptor antagonist (D2R), on GnRH and GnRH receptor (GnRHR) biosynthesis in the hypothalamus and on GnRHR in the anterior pituitary using an immunoassay. This analysis was supplemented by analysis of plasma LH levels by radioimmunoassay...
October 12, 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28988968/kiss1-gene-as-a-novel-mediator-of-tgf%C3%AE-mediated-cell-invasion-in-triple-negative-breast-cancer
#19
Jun Tian, Amal A Al-Odaini, Yun Wang, Juliana Korah, Meiou Dai, Lan Xiao, Suhad Ali, Jean-Jacques Lebrun
The invasive and metastatic phenotypes of breast cancer correlate with high recurrence rates and poor survival outcomes. Transforming growth factor-β (TGFβ) promotes tumor progression and metastasis in aggressive breast cancer. Here, we identified the kisspeptin KiSS1 as a downstream target of canonical TGFβ/Smad2 pathway in triple negative breast cancer cells. We also found KiSS1 expression to be required for TGFβ-induced cancer cell invasion. Indeed, knockdown expression of KiSS1 blocked TGFβ-mediated cancer cell invasion as well as metalloproteinase (MMP9) expression and activity...
October 6, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28985371/the-preoptic-area-and-the-rfamide-related-peptide-neuronal-system-gate-seasonal-changes-in-chemosensory-processing
#20
Kimberly J Jennings, Manon Chasles, Hweyryoung Cho, Jens Mikkelsen, George Bentley, Matthieu Keller, Lance J Kriegsfeld
Males of many species rely on chemosensory information for social communication. In male Syrian hamsters (Mesocricetus auratus), as in many species, female chemosignals potently stimulate sexual behavior and a concurrent, rapid increase in circulating luteinizing hormone (LH) and testosterone (T). However, under winter-like, short-day (SD) photoperiods, when Syrian hamsters are reproductively quiescent, these same female chemosignals fail to elicit behavioral or hormonal responses, even after T replacement...
November 1, 2017: Integrative and Comparative Biology
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