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https://www.readbyqxmd.com/read/28087300/mutual-regulation-by-gnrh-and-kisspeptin-of-their-receptor-expression-and-its-impact-on-the-gene-expression-of-gonadotropin-subunits
#1
Tselmeg Mijiddorj, Haruhiko Kanasaki, Unurjargal Sukhbaatar, Aki Oride, Tomomi Hara, Satoru Kyo
Hypothalamic kisspeptin plays a pivotal role in the regulation of the hypothalamic-pituitary-gonadal axis by stimulating gonadotropin-releasing hormone (GnRH) release into the portal circulation, with the subsequent release of gonadotropins. Kisspeptin and its receptor, the kisspeptin 1 receptor (Kiss1R), are also expressed in the pituitary gland. This study demonstrates the interaction between GnRH and kisspeptin within the pituitary gonadotrophs by altering their individual receptor expression. Our results show that kisspeptin and Kiss1R are expressed in the mouse pituitary gonadotroph cell line LβT2...
January 10, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28040130/correlation-of-kisspeptin-10-level-and-fetal-well-being-in-preeclamptic-patients
#2
Maysoun A Ziyaraa, Farqad B Hamdan, Liqaa R Mousa
OBJECTIVE: This study aims to evaluate the role of kisspeptin-10 in preeclampsia and check for possible relationship between its severity and fetal growth well-being. Kisspeptin-10 may participate in implantation of the embryo, placenta formation, and maintenance of pregnancy. MATERIALS AND METHODS: One hundred women who completed 20 weeks of gestation with singleton pregnancies were divided into 60 peeclamptic and 40 normotensive control women. Kisspeptin-10 level estimation, and ultrasound and Doppler ultrasound studies for umbilical artery were performed during their second and third trimesters of pregnancy...
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28017596/the-role-of-the-kisspeptin-system-in-regulation-of-the-reproductive-endocrine-axis-and-territorial-behavior-in-male-side-blotched-lizards-uta-stansburiana
#3
Lorin Neuman-Lee, Timothy Grieves, Gareth R Hopkins, Susannah S French
The neuropeptide kisspeptin and its receptor are essential for activation of the hypothalamic-pituitary-gonadal (HPG) axis and regulating reproduction. While the role of kisspeptin in regulating the HPG axis in mammals has been well established, little is known about the functional ability of kisspeptins to activate the HPG axis and associated behavior in non-mammalian species. Here we experimentally examined the effects of kisspeptin on downstream release of testosterone and associated aggression and display behaviors in the side-blotched lizard (Uta stansburiana)...
December 23, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/28009489/effects-of-orchidectomy-and-testosterone-replacement-on-numbers-of-kisspeptin-neurokinin-b-and-dynorphin-a-immunoreactive-neurons-in-the-arcuate-nucleus-of-the-hypothalamus-in-obese-and-diabetic-rats
#4
M Dudek, P A Kołodziejski, E Pruszyńska-Oszmałek, K Ziarniak, J H Sliwowska
Neurons expressing kisspeptin, neurokinin B, and dynorphin A, located in the arcuate nucleus of the hypothalamus (ARC), are important regulators of reproduction. Their functions depend on metabolic and hormonal status. We hypothesized that male rats with high-fat diet-induced obesity (DIO) and/or streptozotocin-induced diabetes mellitus type 1 (DM1) and type 2 (DM2) will have: 1) alterations in numbers of immunoreactive (ir) cells: kisspeptin-ir and/or neurokinin B-ir, and dynorphin A-ir neurons in the ARC in the sham condition; 2) orchidectomy alone (ORX) and with testosterone treatment (ORX+T) will unmask possible deficits in the response of these neurons in DIO, and/or DM1 and DM2 rats...
December 23, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28008860/basal-serum-neurokinin-b-level-can-be-used-to-differentiate-idiopathic-central-precocious-puberty-from-premature-thelarche-in-girls
#5
Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz
OBJECTIVE: The aim of the study is to investigate the diagnostic role of kisspeptin and neurokinin B in idiopathic central precocious puberty (ICPP) and premature thelarche (PT). METHODS: The girls who presented with early breast development before the age of 8 years were evaluated. Basal and stimulated FSH, LH levels and basal neurokinin B and kisspeptin levels were measured. Patients who had peak LH > 5mIU/mL, and a bone age (BA) /chronological age (CA) ratio >1...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27997334/ontogeny-of-clock-and-kiss-1-metastasis-suppressor-kiss1-gene-expression-in-the-prepubertal-mouse-hypothalamus
#6
Cassandra C Yap, Peter J Mark, Brendan J Waddell, Jeremy T Smith
Kisspeptin is crucial for the generation of the circadian-gated preovulatory gonadotrophin-releasing hormone (GnRH)-LH surge in female rodents, with expression in the anteroventral periventricular nucleus (AVPV) peaking in the late afternoon of pro-oestrus. Given kisspeptin expression is established before puberty, the aim of the present study was to investigate kisspeptin and clock gene rhythms during the neonatal period. Anterior and posterior hypothalami were collected from C57BL/6J mice on Postnatal Days (P) 5, 15 and 25, at six time points across 24h, for analysis of gene expression by reverse transcription-quantitative polymerase chain reaction...
December 21, 2016: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/27990162/the-changes-of-serum-leptin-and-kisspeptin-levels-in-chinese-children-and-adolescents-in-different-pubertal-stages
#7
Hui Juan Zhu, Su Juan Li, Hui Pan, Naishi Li, Dian Xi Zhang, Lin Jie Wang, Hong Bo Yang, Qinyong Wu, Feng Ying Gong
The aim of the study is to investigate the changes of serum leptin and kisspeptin levels in children and adolescents with different pubertal stages and nutritional states. A total of 647 Chinese children and adolescents were recruited, and serum estradiol, testosterone, pituitary gonadotropins, leptin, and kisspeptin levels were measured. The results showed that serum leptin levels of boys in T2 stage were the highest among the five stages, while they showed a gradual increase from T1 to T5 stage in girls and reached the highest in T5 stage (P < 0...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27983870/kisspeptin-in-the-hypothalamus-of-two-rat-models-of-polycystic-ovary-syndrome
#8
Satoko Osuka, Akira Iwase, Tatsuo Nakahara, Mika Kondo, Ai Saito, Bayasula, Tomoko Nakamura, Sachiko Takikawa, Maki Goto, Tomomi Kotani, Fumitaka Kikkawa
Hyperandrogenism, disturbance of the hypothalamus-pituitary-ovary axis followed by elevated serum luteinizing hormone (LH) levels, and insulin resistance are involved in the complicated pathophysiology of polycystic ovary syndrome (PCOS). Kisspeptin is co-expressed with neurokinin B (NKB) in the arcuate nucleus (ARC), the center of the gonadotropin-releasing hormone (GnRH)-pulse generator that is responsible for pulsatile LH secretion. We compared two androgenized rat models of PCOS to evaluate the estrous cycle, hormonal profiles, and expression of kisspeptin and NKB in the ARC...
December 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27983867/roles-of-rfrp-3-in-the-daily-and-seasonal-regulation-of-reproductive-activity-in-female-syrian-hamsters
#9
Jo B Henningsen, Caroline Ancel, Jens D Mikkelsen, François Gauer, Valérie Simonneaux
In females, reproductive activity relies on proper integration of daily and environmental changes as well as cyclic sex-steroid feedback. This study aimed at investigating the role of the hypothalamic Arg-Phe amide-related peptide (RFRP)-3 in the daily and seasonal control of reproductive activity in female Syrian hamsters, by analyzing the RFRP system and investigating the effects of central administration of RFRP-3 at different reproductive stages. In long day-adapted sexually active female hamsters, the number of c-Fos activated RFRP-ir neurons was reduced in the afternoon of diestrus and proestrus, the latter being correlated with increased kisspeptin activity and the LH surge...
December 16, 2016: Endocrinology
https://www.readbyqxmd.com/read/27981646/characterization-of-kiss1r-gpr54-expressing-neurons-in-the-arcuate-nucleus-of-the-female-rat-hypothalamus
#10
Shimpei Higo, Norio Iijima, Hitoshi Ozawa
Kisspeptin is essential in reproduction, and acts by stimulating neurons expressing gonadotropin-releasing hormone (GnRH). Recent studies suggest that kisspeptin has multiple roles in the modulation of neuronal circuits in systems outside the hypothalamic-pituitary-gonadal axis. Our recent research using in situ hybridization (ISH) clarified the histological distribution of Kiss1r (Gpr54)-expressing neurons in the rat brain which were presumed to be putative targets of kisspeptin. The arcuate nucleus (ARN) of the hypothalamus is one of the brain regions in which Kiss1r expression in non-GnRH neurons is prominent...
December 16, 2016: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/27957681/dynamic-regulation-of-hypothalamic-dmxl2-kiss1-and-rfrp-expression-during-postnatal-development-in-non-human-primates
#11
Fazal Wahab, Charis Drummer, Stefan Schlatt, Rüdiger Behr
The neurobiological mechanism of puberty onset in primates is currently only partly understood. A recent study reported an important role of Dmx-like 2 (DMXL2), a gene encoding rabconnectin-3α vesicular protein, in human subjects with mental retardation and neuroendocrine impairment of reproduction. To further characterize the potential role of DMXL2 in the regulation of reproduction, we analyzed the expression of DMXL2 in hypothalami of newborn, infantile, juvenile, pubertal, and postpubertal female and male common marmoset monkeys...
December 12, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27942879/the-sesquiterpene-%C3%AE-bisabolol-in-the%C3%A2-adipocyte-cancer-desmoplastic-crosstalk-does-it-have-an-action-on-epithelial-mesenchymal-transition-mechanisms
#12
REVIEW
Salvatore Chirumbolo, Geir Bjørklund
Alpha-bisabolol is a plant-derived sesquiterpene alcohol recently associated with a supposed anti-cancer action due to its ability to induce BID-related apoptosis. The molecule, which enters the cell through lipid rafts, may also interact with kisspeptin receptor 1, which has recently been associated with tumor mobility and invasiveness. This evidence suggests the possibility that α-bisabolol might act on the epithelial-mesenchymal transition mechanism, closely associated with the desmoplastic reaction of adipose tissue surrounding a pancreatic ductal adenocarcinoma...
December 9, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27940396/immunohistochemical-expression-pattern-of-metastasis-suppressor-kiss-1-protein-in-adenomyosis-lesions-and-normal-endometrium
#13
I Kolioulis, M Zafrakas, G Grimbizis, D Miliaras, A Timologou, J N Bontis, B C Tarlatzis
OBJECTIVE: Kisspeptins are multifunctional peptides; it has been shown that they act as inhibitors of tumor metastasis in a range of cancers and that they are also involved in cell invasion through regulation of matrix metalloproteinases (MMPs). The aim of this study was to investigate the expression of KISS-1 protein in adenomyosis lesions compared with matched eutopic endometrium, as well as with endometrium from patients without adenomyosis. STUDY DESIGN: In this comparative, non-interventional study, adenomyosis and corresponding eutopic endometrium samples from women with histologically proven adenomyosis after hysterectomy, and eutopic endometrium samples from women without adenomyosis were analysed...
December 5, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27916574/temperature-affects-sexual-maturation-through-the-control-of-kisspeptin-kisspeptin-receptor-gnrh-and-gth-subunit-gene-expression-in-the-grass-puffer-during-the-spawning-season
#14
Md Shahjahan, Takashi Kitahashi, Hironori Ando
Water temperature is an environmental factor of primary importance that influences reproductive function in fish. To understand the molecular and physiological mechanisms underlying the regulation of reproduction by temperature, we examined changes in expression of genes encoding kisspeptin (kiss2), kisspeptin receptor (kiss2r) and three gonadotropin-releasing hormones (gnrh1, gnrh2 and gnrh3) in the brain and genes encoding gonadotropin (GTH) subunits (gpa, fshb and lhb) in the pituitary of grass puffer exposed to a low temperature (14°C), normal temperature (21°C) and high temperature (28°C) for 7days...
December 1, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27914139/genetic-variations-of-the-kiss1r-gene-in-korean-girls-with-central-precocious-puberty
#15
Yeon Joung Oh, Young Jun Rhie, Hyo Kyoung Nam, Hye Ryun Kim, Kee Hyoung Lee
The timing of puberty onset varies greatly among individuals, and much of this variation is modulated by genetic factors. This study aimed to identify the kisspeptin receptor (KISS1R) gene variations and to investigate the associations between these variations and central precocious puberty (CPP). Korean girls with CPP (n = 194) and their healthy controls (n = 99) were included in this study. The entire coding region and the exon-intron boundaries (exon 1 through 5) of the KISS1R gene were directly sequenced...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27908602/kisspeptin-and-embryo-implantation-after-icsi
#16
Zehra Jamil, Syeda Sadia Fatima, Sara Arif, Faiza Alam, Rehana Rehman
A cross-sectional study was carried out at the Australian Concept Infertility Medical Centre from June 2014 to June 2015 to relate serum kisspeptin levels on human chorionic gonadotrophin (HCG) day with pregnancy outcome after intracytoplasmic sperm injection (ICSI). A total of 176 women aged 20 to 42 years, with regular menstrual cycles, normal thyroid function and prolactin levels selected for ICSI were included in the study. Patients with uterine fibroids, metabolic disorders, short agonist and antagonist protocol were excluded...
November 18, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27902923/kisspeptin-expression-is-decreased-in-the-arcuate-nucleus-of-hypothyroid-female-rats-with-irregular-estrus-cycles
#17
Yuji Tomori, Ken Takumi, Norio Iijima, Shinro Takai, Hitoshi Ozawa
Insufficiency of thyroid hormones inhibits gonadotropin release and results in dysregulation of reproductive function, although the precise mechanism of this disrupted gonadotropin secretion remains unclear. Kisspeptin is a neuropeptide that strongly stimulates gonadotropin secretion and plays an important role in reproductive function. To examine the involvement of kisspeptin in the dysregulation of gonadotropin secretion in hypothyroidism, we investigated Kiss1 mRNA expression and kisspeptin immunoreactivity in the hypothalamus of female rats treated with propylthiouracil (PTU)...
November 27, 2016: Neuroscience Research
https://www.readbyqxmd.com/read/27901187/interactions-between-prolactin-and-kisspeptin-to-control-reproduction
#18
Jose Donato, Renata Frazão
Prolactin is best known for its effects of stimulating mammary gland development and lactogenesis. However, prolactin is a pleiotropic hormone that is able to affect several physiological functions, including fertility. Prolactin receptors (PRLRs) are widely expressed in several tissues, including several brain regions and reproductive tract organs. Upon activation, PRLRs may exert prolactin's functions through several signaling pathways, although the recruitment of the signal transducer and activator of transcription 5 causes most of the known effects of prolactin...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27900820/investigation-of-the-effects-of-kisspeptin-10-in-methionine-induced-lipid-peroxidation-in-testicle-tissue-of-young-rats
#19
Hatice Akkaya, Signem Eyuboglu, Gozde Erkanlı Senturk, Bayram Yilmaz
Disruption of the balance oxidants, antioxidants cause various pathophysiological conditions such as lipid peroxidation, protein degradation, or DNA damage. We have examined possible effects of kisspeptin-10 on the structural damage produced by methionine-induced lipid peroxidation in testicle tissue of young rats. Kisspeptin-10 did not significantly affect spermatogenic cells in seminiferous tubules. Testosterone levels decreased in the methionine group as compared with the control group but without statistical significance...
November 30, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27890710/in-vivo-and-vitro-characterization-of-the-effects-of-kisspeptin-13-endogenous-ligands-for-gpr54-on-mouse-gastrointestinal-motility
#20
Jinhong Jiang, Weidong Jin, Yali Peng, Zhen He, Lijuan Wei, Shu Li, Xiaoli Wang, Min Chang, Rui Wang
Kisspeptin (KP), the endogenous ligand of GPR54, is a mammalian amidated neurohormone, which belongs to the RF-amide peptide family. However, in contrast with the related members of the RF-amide family, little information is available regarding its role in the gastrointestinal motility. With regard to the recent data suggesting KP play an important role in food intake, and while gastrointestinal motility are closely related to it. Thus, in the present work, effects of central administration of KP-13, one of the endogenous active isoforms, on gastrointestinal motility were investigated...
January 5, 2017: European Journal of Pharmacology
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