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https://www.readbyqxmd.com/read/29779845/effects-of-estradiol-on-lactoprivic-signaling-of-the-hindbrain-upon-the-contraregulatory-hormonal-response-and-metabolic-neuropeptide-synthesis-in-hypoglycemic-female-rats
#1
Santosh K Mandal, Prem K Shrestha, Fahaad S H Alenazi, Manita Shakya, Hussain N Alhamami, Karen P Briski
BACKGROUND: Caudal dorsomedial hindbrain detection of hypoglycemia-associated lactoprivation regulates glucose counter-regulation in male rats. In females, estradiol (E) determines hypothalamic neuroanatomical and molecular foci of hindbrain energy sensor activation. This study investigated the hypothesis that E signal strength governs metabolic neuropeptide and counter-regulatory hormone responses to hindbrain lactoprivic stimuli in hypoglycemic female rats. METHODS: Ovariectomized animals were implanted with E-filled silastic capsules [30 (E-30) or 300 μg (E-300)/mL] to replicate plasma concentrations at estrous cycle nadir versus peak levels...
May 17, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29773976/facing-the-challenges-of-neuropeptide-gene-knockouts-why-do-they-not-inhibit-reproduction-in-adult-teleost-fish
#2
REVIEW
Vance L Trudeau
Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed. Genome editing using transcription activator-like effector nuclease in zebrafish and medaka has established the role of follicle stimulating hormone for gonadal development and luteinizing hormone for ovulation. Attempts to genetically manipulate the hypophysiotropic neuropeptidergic systems have been less successful...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29772257/conspecific-odor-exposure-predominantly-activates-non-kisspeptin-cells-in-the-medial-nucleus-of-the-amygdala
#3
Leandro Bueno Lima, Fernanda Tais Haubenthal, Marina Augusto Silveira, Tabata Mariz Bohlen, Martin Metzger, Jose Donato, Renata Frazao
A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections...
May 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29760678/controversial-role-of-kisspeptins-kiss-1r-signaling-system-in-tumor-development
#4
REVIEW
Federica Fratangelo, Maria Vincenza Carriero, Maria Letizia Motti
KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29755406/the-role-of-kiss1-neurons-as-integrators-of-endocrine-metabolic-and-environmental-factors-in-the-hypothalamic-pituitary-gonadal-axis
#5
REVIEW
Shel-Hwa Yeo, William H Colledge
Kisspeptin-GPR54 signaling in the hypothalamus is required for reproduction and fertility in mammals. Kiss1 neurons are key regulators of gonadotropin-releasing hormone (GnRH) release and modulation of the hypothalamic-pituitary-gonadal (HPG) axis. Arcuate Kiss1 neurons project to GnRH nerve terminals in the median eminence, orchestrating the pulsatile secretion of luteinizing hormone (LH) through the intricate interaction between GnRH pulse frequency and the pituitary gonadotrophs. Arcuate Kiss1 neurons, also known as KNDy neurons in rodents and ruminants because of their co-expression of neurokinin B and dynorphin represent an ideal hub to receive afferent inputs from other brain regions in response to physiological and environmental changes, which can regulate the HPG axis...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29746990/hindbrain-5-monophosphate-activated-protein-kinase-mediates-short-term-food-deprivation-inhibition-of-the-gonadotropin-releasing-hormone-luteinizing-hormone-axis-role-of-nitric-oxide
#6
Manita Shakya, Prem K Shrestha, Karen P Briski
Hindbrain-derived stimuli restrain the gonadotropin-releasing hormone (GnRH)-pituitary luteinizing hormone (LH) reproductive neuroendocrine axis during energy insufficiency. Interruption of food intake, planned or unplanned, is emblematic of modern life. This study investigated the premise that the hindbrain energy sensor adenosine 5'-monophosphate-activated protein kinase (AMPK) inhibits reproductive neuroendocrine function in short-term, e.g. 18 hr food-deprived (FD) estradiol (E)-implanted ovariectomized female rats...
May 7, 2018: Neuroscience
https://www.readbyqxmd.com/read/29745981/evaluation-of-biochemical-endocrine-and-metabolic-biomarkers-for-the-early-diagnosis-of-polycystic-ovary-syndrome-among-non-obese-saudi-women
#7
Maha H Daghestani
OBJECTIVE: To investigate the potential of selected biochemical, endocrine, and metabolic biomarkers for early diagnosis of polycystic ovary syndrome (PCOS) among non-obese women. METHODS: A prospective observational cross-sectional study was conducted at three medical centers in Makkah, Saudi Arabia, between July 15 and September 20, 2017. Eligible participants were non-obese women diagnosed with PCOS according to the Rotterdam criteria (n=44) and non-obese normo-ovulatory women without signs of PCOS (control group; n=44)...
May 10, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29743877/follicle-size-on-day-of-trigger-most-likely-to-yield-a-mature-oocyte
#8
Ali Abbara, Lan N Vuong, Vu N A Ho, Sophie A Clarke, Lisa Jeffers, Alexander N Comninos, Rehan Salim, Tuong M Ho, Tom W Kelsey, Geoffrey H Trew, Peter Humaidan, Waljit S Dhillo
Objective: To identify follicle sizes on the day of trigger most likely to yield a mature oocyte following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment. Design: Retrospective analysis to determine the size of follicles on day of trigger contributing most to the number of mature oocytes retrieved using generalized linear regression and random forest models applied to data from IVF cycles (2014-2017) in which either hCG, GnRHa, or kisspeptin trigger was used...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29740399/the-emerging-role-s-for-kisspeptin-in-metabolism-in-mammals
#9
REVIEW
Andrew Wolfe, Mehboob A Hussain
Kisspeptin was initially identified as a metastasis suppressor. Shortly after the initial discovery, a key physiologic role for kisspeptin emerged in the regulation of fertility, with kisspeptin acting as a neurotransmitter via the kisspeptin receptor, its cognate receptor, to regulate hypothalamic GnRH neurons, thereby affecting pituitary-gonadal function. Recent work has demonstrated a more expansive role for kisspeptin signaling in a variety of organ systems. Kisspeptin has been revealed as a significant player in regulating glucose homeostasis, feeding behavior, body composition as well as cardiac function...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29729480/the-anti-androgenic-effect-of-chronic-exposure-to-semicarbazide-on-male-japanese-flounder-paralichthys-olivaceus-and-its-potential-mechanisms
#10
Zonghao Yue, Miao Yu, Xiaona Zhang, Jun Wang, Shaoguo Ru
Semicarbazide (SMC), a new marine pollutant, has anti-estrogenic effects on female Japanese flounder (Paralichthys olivaceus). However, whether SMC also affects the reproductive endocrine system of male marine organisms is currently unclear. In this study, Japanese flounder embryos were exposed to 1, 10, and 100 μg/L SMC for 130 days. Plasma testosterone (T) and 17β-estradiol (E2 ) concentrations were significantly decreased in male flounders after SMC exposure. The expression of genes involved in T and E2 synthesis, including steroidogenic acute regulatory protein, cytochrome P450 11A1, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase and cytochrome P450 19A, was down-regulated in the gonads, which may explain the decrease in plasma sex hormones levels...
May 2, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29729230/role-of-hypothalamus-in-aging-and-its-underlying-cellular-mechanisms
#11
REVIEW
Keetae Kim, Han Kyoung Choe
Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brain region that connects the neuroendocrine system to physiological functions. In addition, functional alterations in a set of agouti-related peptide/neuropeptide Y (AgRP/NPY) and pro-opiomelanocortin (POMC) neurons, a set of growth hormone-releasing hormone (GHRH) and somatostatin (SST) neurons, a set of arginine vasopressin (AVP) and vasoactive intestinal peptide (VIP) neurons, and a set of gonadotropin-releasing hormone (GnRH) and kisspeptin/neurokinin B/dynorphin (KNDy) neurons contribute to age-related physiological decline in energy metabolism, hormone regulation, circadian rhythm, and reproduction, respectively...
May 2, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29728876/kisspeptin-and-lh-pulsatile-temporal-coupling-in-pcos-patients
#12
Krzysztof Katulski, Agnieszka Podfigurna, Adam Czyzyk, Blazej Meczekalski, Alessandro D Genazzani
PURPOSE: To evaluate the temporal coupling between spontaneous kisspeptin and luteinizing hormone (LH) pulsatile releases in polycystic ovary syndrome (PCOS) patients. METHODS: We examined 71 patients diagnosed with PCOS. A 2 h pulsatility study was performed to evaluate serum kisspeptin and LH pulse frequency and concentration, sampled every 10 min; baseline follicle-stimulating hormone (FSH), estradiol (E2), prolactin (PRL), cortisol, 17-hydroksy-progesterone (17OHP), testosterone (T), free testosterone index (FTI, and insulin levels were also measured...
May 4, 2018: Endocrine
https://www.readbyqxmd.com/read/29721201/antitumor-efficacy-of-kisspeptin-in-human-malignant-mesothelioma-cells
#13
Vincenza Ciaramella, Carminia Maria Della Corte, Concetta Di Mauro, Stefano Tomassi, Salvatore Di Maro, Teresa Troiani, Erika Martinelli, Roberto Bianco, Sandro Cosconati, Riccardo Pierantoni, Rosaria Meccariello, Rosanna Chianese, Fortunato Ciardiello, Floriana Morgillo
Purpose: Kisspeptin signaling, via its receptors GPR54, could be an essential players in the inhibition of mesothelioma progression, invasion and metastasis formation. The loss of KiSS1 by tumor cells has been associated with a metastatic phenotype but the mechanistic insights of this process are still unknown. Experimental design: The blockade of the metastatic process at early stage is a hot topic in cancer research. We studied the role of KiSS1 on proliferation, invasiveness, migration abilities of mesothelioma cell lines focusing on the effect on epithelial-to-mesenchymal transition (EMT)...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720538/sympathetic-innervation-regulates-macrophage-activity-in-rat-with-polycystic-ovary
#14
Florencia Figueroa, Gisela Mendoza, Dario Cardozo, Fabian Mohamed, Liliana Oliveros, Myriam Liliana Forneris
Polycystic ovary syndrome (PCOS) is a low grade inflammatory disease characterized by hyperandrogenism and ovarian hyperinnervation. The aim of this work is to investigate whether in vivo bilateral superior ovarian nerve (SON) section in adult rats with estradiol valerate induced polycystic ovarian syndrome (PCO rats) affects macrophage spleen cells (MФ) and modifies the steroidogenic ability of their secretions. Culture media of MФ from PCO rats and PCO rats with SON section (PCO-SON rats) were used to stimulate in vitro intact ovaries...
May 2, 2018: Journal of Endocrinology
https://www.readbyqxmd.com/read/29713310/kisspeptin-and-metabolism-the-brain-and-beyond
#15
REVIEW
Monika Dudek, Kamil Ziarniak, Joanna H Sliwowska
Apart from the well-established role of kisspeptin (Kp) in the regulation of reproductive functions, recent data described its action in the control of metabolism. Of particular interest for the review is the population of Kp neurons localized in the arcuate nucleus (ARC) of the hypothalamus, the site of the brain where reproductive and metabolic cross talk occurs. However, within the hypothalamus Kp does not work alone, but rather interacts with other neuropeptides, e.g., neurokinin B, dynorphin A, proopiomelanocortin, the cocaine- and amphetamine-regulated transcript, agouti-related peptide, and neuropeptide Y...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29709623/kisspeptin-modulates-pain-sensitivity-of-cflp-mice
#16
Krisztina Csabafi, Zsolt Bagosi, Éva Dobó, Júlia Szakács, Gyula Telegdy, Gyula Szabó
Kisspeptin, a hypothalamic neuropeptide, is a member of the RF-amide family, which have been known to modify pain sensitivity in rodents. The aim of the present study was to investigate the effect of kisspeptin-13 (KP-13), an endogenous derivative of kisspeptin, on nociception in adult male and female CFLP mice and the possible interaction of KP-13 with morphine on nociception. Mice were injected with different doses of KP-13, 30, 60 and 120 min after of which the nociceptive sensitivity were assessed via the tail-flick test...
April 27, 2018: Peptides
https://www.readbyqxmd.com/read/29698886/presence-and-function-of-kisspeptin-kiss1r-system-in-swine-ovarian-follicles
#17
G Basini, F Grasselli, S Bussolati, R Ciccimarra, M Maranesi, A Bufalari, F Parillo, M Zerani
Kisspeptin and its receptor KISS1R are involved in the neuroendocrine regulation of mammalian reproduction and their role on follicular development and function can be hypothesized. The present work was designed to confirm the immunopresence of kisspeptin and its receptor in the ovary of swine and to study the effects of kisspeptin 10 and its antagonist, kisspeptin 234, on main functional parameters of granulosa cells (i.e. cell proliferation, steroid production, and redox status) as well as their modulatory action on angiogenesis...
April 5, 2018: Theriogenology
https://www.readbyqxmd.com/read/29692674/co-expression-of-the-calcitonin-receptor-gene-in-the-hypothalamic-kisspeptin-neurons-in-female-rats
#18
Assadullah, Nahoko Ieda, Narumi Kawai, Hirotaka Ishii, Kunio Ihara, Naoko Inoue, Yoshihisa Uenoyama, Hiroko Tsukamura
Purpose: Hypothalamic kisspeptin neurons are considered to play a critical role in regulating mammalian reproduction and integrating humoral and neuronal inputs that control gonadotropin-releasing hormone (GnRH)/gonadotropin release. The present study aimed to investigate the upstream regulator candidates for kisspeptin neurons. Methods: Visualized kisspeptin neurons that were taken from the arcuate nucleus (ARC) of Kiss1 -tdTomato rats were subjected to next-generation sequencing (NGS) analysis...
April 2018: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29689132/alcohol-delays-the-onset-of-puberty-in-the-female-rat-by-altering-key-hypothalamic-events
#19
Vinod K Srivastava, Jill K Hiney, William L Dees
BACKGROUND: Because alcohol (ALC) delays signs of pubertal development, we assessed the time course of events associated with the synthesis of critical hypothalamic peptides that regulate secretion of luteinizing hormone-releasing hormone (LHRH), the peptide that drives the pubertal process. METHODS: Immature female rats were administered either lab chow or Bio-Serve isocaloric control or ALC liquid diets from 27 through 33 days of age. On days 28, 29, 31 and 33 animals were killed by decapitation and tissue blocks containing the medial basal hypothalamus (MBH) and the rostral hypothalamic area (RHA) were isolated and stored frozen until assessed by Western blot analysis...
April 24, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29682539/effect-of-kisspeptin-on-the-developmental-competence-and-early-transcript-expression-in-porcine-oocytes-parthenogenetically-activated-with-different-methods
#20
Islam M Saadeldin, Ayman Abdel-Aziz Swelum, Aaser M Abdelazim, Essam A Almadaly
Recent studies showed the modulatory effect of kisspeptin (KP) on calcium waves through the cell membrane and inside the cell. Spermatozoon can induce similar ooplasmic calcium oscillations at fertilization to trigger meiosis II. Here, we evaluated the effect of KP supplementation with 6-dimethylaminopurine (6-DMAP) for 4 h on embryonic development after oocyte activation with single electric pulse, 5 µ M ionomycin, or 8% ethanol. Compared to control nonsupplemented groups, KP significantly improved embryo developmental competence electric- and ethanol-activated oocytes in terms of cleavage (75...
2018: BioMed Research International
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