keyword
MENU ▼
Read by QxMD icon Read
search

kisspeptin

keyword
https://www.readbyqxmd.com/read/28435188/effect-of-kisspeptin-on-in-vitro-maturation-of-sheep-oocytes
#1
Priyanka Byri, Arunakumari Gangineni, K Ramachandra Reddy, K B P Raghavender
AIM: The aim of this study was to investigate the effect of kisspeptin (KP) on in vitro maturation (IVM) of sheep oocytes aspirated from the ovaries collected from slaughterhouse. MATERIALS AND METHODS: Two different experiments were conducted to investigate the effect of KP (5, 10 and 15 µg/ml) alone (experiment 1) or in combination with follicle-stimulating hormone (FSH), luteinizing hormone (LH), and Estradiol (E2) (experiment 2) on IVM of sheep oocytes. Tissue culture medium 199 supplemented with Gentamicin was used as control medium...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28429258/hormonal-regulation-of-nk-cell-cytotoxic-activity
#2
S V Shirshev, I V Nekrasova, O L Gorbunova, E G Orlova
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
January 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28427900/molecular-cloning-and-characterization-of-kiss1-in-brandt-s-voles-lasiopodomys-brandtii
#3
Yan Chen, Lan Liu, Zhengguang Li, Dawei Wang, Ning Li, Ying Song, Cong Guo, Xiaohui Liu
Kisspeptin, encoded by kiss1, has been regarded as a major modulator of mammalian puberty and fertility due to its stimulation on GnRH. Brandt's vole is one of the main pest species on the Inner Mongolian steppes for its striking reproductive capacity and kiss1 is a key candidate gene related to reproductive regulatory cascades. In this study, kiss1 cDNA was cloned from the hypothalamus of Brandt's voles and kiss1 mRNA levels were investigated in different tissues, and at different developmental stages, using high-throughput real-time PCR...
April 18, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28422705/plasma-kisspeptin-and-ghrelin-levels-in-puberty-variant-cases
#4
Erdal Kurnaz, Yaşar Şen, Süleyman Aydın
BACKGROUND: The aim of this study was to determine the serum levels of kisspeptin and ghrelin (GAH), as well as the relationship of these two peptides with each other in premature thelarche (PT) and premature adrenarche (PA) cases and to investigate the possibility of using these peptides as markers in the differentiation of puberty disorders. METHODS: A PT group aged 1-8 years (n = 40), a PA group aged 1-9 years (n = 23, female/male = 20/3) and control groups consistent with each of the previous groups in terms of age and gender were created for the study...
April 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28422142/g-protein-coupled-kiss1-receptor-is-overexpressed-in-triple-negative-breast-cancer-and-promotes-drug-resistance
#5
Alexandra Blake, Magdalena Dragan, Rommel G Tirona, Daniel B Hardy, Muriel Brackstone, Alan B Tuck, Andy V Babwah, Moshmi Bhattacharya
Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor α, progesterone receptor and human epidermal growth factor receptor 2 (HER2). TNBC patients lack targeted therapies, as they fail to respond to endocrine and anti-HER2 therapy. Prognosis for this aggressive cancer subtype is poor and survival is limited due to the development of resistance to available chemotherapies and resultant metastases. The mechanisms regulating tumor resistance are poorly understood. Here we demonstrate that the G protein-coupled kisspeptin receptor (KISS1R) promotes drug resistance in TNBC cells...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28411243/potent-vasoconstrictor-kisspeptin-10-induces-atherosclerotic-plaque-progression-and-instability-reversal-by-its-receptor-gpr54-antagonist
#6
Kengo Sato, Remina Shirai, Mina Hontani, Rina Shinooka, Akinori Hasegawa, Tomoki Kichise, Tomoyuki Yamashita, Hayami Yoshizawa, Rena Watanabe, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Shinji Koba, Youichi Kobayashi, Tsutomu Hirano, Takuya Watanabe
BACKGROUND: Kisspeptin-10 (KP-10), a potent vasoconstrictor and inhibitor of angiogenesis, and its receptor, GPR54, have currently received much attention in relation to pre-eclampsia. However, it still remains unknown whether KP-10 could affect atherogenesis. METHODS AND RESULTS: We evaluated the effects of KP-10 on human umbilical vein endothelial cells, human monocyte-derived macrophages, human aortic smooth muscle cells in vitro, and atherosclerotic lesions in apolipoprotein E-deficient (ApoE(-/-)) mice in vivo...
April 14, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28409493/obesity-in-pregnancy-a-novel-concept-on-the-roles-of-adipokines-in-uterine-contractility
#7
REVIEW
Judit Hajagos-Tóth, Eszter Ducza, Reza Samavati, Sandor G Vari, Robert Gaspar
Obesity is a global health problem even among pregnant women. Obesity alters quality of labor, such as preterm labor, prolonged labor, and higher oxytocin requirements in pregnant women. The most important factors to play a role in the altered gestational period and serve as drug targets to treat the consequences are female sexual hormones, calcium channels, adrenergic system, oxytocin, and prostaglandins. However, we have limited information about the impact of obesity on the pregnant uterine contractility and gestation time...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28393578/kisspeptin-as-a-promising-oocyte-maturation-trigger-for-in-vitro-fertilisation-in-humans
#8
Miro Kasum, Daniela Franulić, Ermin Čehić, Slavko Orešković, Albert Lila, Emina Ejubović
The aim of this review is to analyse the effectiveness of exogenous kisspeptin administration as a novel alternative of triggering oocyte maturation, instead of currently used triggers such as human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) agonist, in women undergoing in vitro fertilisation (IVF) treatment. Kisspeptin has been considered a master regulator of two modes of GnRH and hence gonadotropin secretion, pulses and surges. Administration of kisspeptin-10 and kisspeptin-54 induces the luteinising hormone (LH) surge required for egg maturation and ovulation in animal investigations and LH release during the preovulatory phase of the menstrual cycle and hypothalamic amenorrhoea in humans...
April 10, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28387824/alpha-estrogen-and-progesterone-receptors-modulate-kisspeptin-effects-on-prolactin-role-in-estradiol-induced-prolactin-surge-in-female-rats
#9
Nayara S S Aquino, Roberta Araujo-Lopes, Patricia C Henriques, Felipe E F Lopes, Daniela O Gusmao, Candido C Coimbra, Celso R Franci, Adelina M Reis, Raphael E Szawka
Kisspeptin regulates prolactin (PRL) in an estradiol-dependent manner. We investigated the interaction between ovarian-steroid receptors and kisspeptin in the control of PRL secretion. Intracerebroventricular injections of kisspeptin-10 (Kp-10) or kisspeptin-234 (Kp-234) were performed in ovariectomized (OVX) rats under different hormonal treatments. Kp-10 increased PRL release and decreased 3,4-dihydroxyphenylacet acid (DOPAC) levels in the median eminence (ME) of OVX rats treated with estradiol (OVX+E), which was prevented by tamoxifen...
April 6, 2017: Endocrinology
https://www.readbyqxmd.com/read/28384629/estrogen-and-progesterone-integration-in-an-in-vitro-model-of-rp3v-kisspeptin-neurons
#10
Melinda A Mittelman-Smith, Angela M Wong, Paul E Micevych
No abstract text is available yet for this article.
April 7, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28380486/neurokinin-3-receptor-antagonism-reveals-roles-for-neurokinin-b-in-the-regulation-of-gonadotropin-secretion-and-hot-flashes-in-postmenopausal-women
#11
Karolina Skorupskaite, Jyothis T George, Johannes D Veldhuis, Robert P Millar, Richard A Anderson
OBJECTIVES: Neurokinin B (NKB) and kisspeptin are obligate for normal gonadotropin secretion, and links between GnRH pulsatility and vasomotor symptoms have been proposed. Using a selective NKB receptor (NK3R) antagonist, the role of NKB in the hypergonadotropic state in menopausal women was explored. METHODS: Eleven postmenopausal women were administered the NK3R antagonist MLE4901, 40 mg twice daily orally for 7 days. 10-min blood sampling for 8 h was performed before and on the last day of NK3R antagonist treatment for LH pulsatility analysis with kisspeptin-10 (0...
April 5, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28379327/evidence-that-endogenous-somatostatin-inhibits-episodic-but-not-surge-secretion-of-lh-in-female-sheep
#12
Richard B McCosh, Brett M Szeligo, Michelle N Bedenbaugh, Justin A Lopez, Steven L Hardy, Stanley M Hileman, Michael N Lehman, Robert L Goodman
Two modes of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion are necessary for female fertility: surge and episodic secretion, however the neural systems that regulate these GnRH secretion patterns are still under investigation. The neuropeptide somatostatin (SST) inhibits episodic luteinizing hormone (LH) secretion in humans and sheep, and several lines of evidence suggest SST may regulate secretion during the LH surge. In this study, we examined whether SST alters the LH surge in ewes by administering a SST receptor 2 (SSTR2) agonist (octreotide) or antagonist (CYN154806; CYN) into the third ventricle during an estrogen-induced LH surge, and whether endogenous SST alters episodic LH secretion...
April 3, 2017: Endocrinology
https://www.readbyqxmd.com/read/28377404/effect-of-androgen-on-kiss1-expression-and-luteinizing-hormone-release-in-female-rats
#13
Kinuyo Iwata, Yuyu Kunimura, Keisuke Matsumoto, Hitoshi Ozawa
Hyperandrogenic women have various grades of ovulatory dysfunction, which lead to infertility. The purpose of this study was to determine whether chronic exposure to androgen affects expression of kisspeptin (ovulation and follicle development regulator) or release of luteinizing hormone (LH) in female rats. Weaned females were subcutaneously implanted with 90-day continuous-release pellets of 5α-dihydrotestosterone (DHT) and studied after 10 weeks of age. Number of Kiss1-expressing cells in both the anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC) was significantly decreased in ovary-intact DHT rats...
April 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28370545/molecular-mechanism-of-feedback-regulation-of-17%C3%AE-estradiol-on-two-kiss-genes-in-the-protogynous-orange-spotted-grouper-epinephelus-coioides
#14
Yin Guo, Qingqing Wang, Gaofei Li, Meng He, Haipei Tang, Haifa Zhang, Xiaoli Yang, Xiaochun Liu, Haoran Lin
Kisspeptins are considered critical regulators in the hypothalamic-pituitary-gonadal axis because they can stimulate secretion of Gonadotropin-releasing hormone in mammals, and may also mediate the feedback regulation of sex steroids in the hypothalamus. Two kiss1 paralogues (kiss1 and kiss2) were identified in teleosts, hinting at their increased complexity of signaling for sex-steroid feedback regulation. In the present study, molecular pathways by which 17β-estradiol (E2 ) exerted feedback regulation on two kiss genes, via three types of estrogen receptors, were investigated in the protogynous orange-spotted grouper (Epinephelus coioides)...
March 30, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28368450/long-term-neonatal-estrogen-exposure-causes-irreversible-inhibition-of-lh-pulses-by-suppressing-arcuate-kisspeptin-expression-via-estrogen-receptors-%C3%AE-and-%C3%AE-in-female-rodents
#15
Shiori Minabe, Nahoko Ieda, Youki Watanabe, Naoko Inoue, Yoshihisa Uenoyama, Kei-Ichiro Maeda, Hiroko Tsukamura
Exposure to estrogen during the developmental period causes reproductive dysfunction in mammals, as the developing brain is highly sensitive to estrogens. Here we report that long-term exposure to supraphysiological doses of estrogen during the neonatal critical period causes an irreversible suppression of Kiss1/kisspeptin expression in the arcuate nucleus (ARC) via the estrogen receptor alpha (ERα) and ERβ, resulting in reproductive dysfunction in female rats. Daily estradiol-benzoate (EB) administration from days 0 to 10 postpartum caused persistent vaginal diestrus in female rats...
March 29, 2017: Endocrinology
https://www.readbyqxmd.com/read/28368443/continuous-kisspeptin-administration-in-postmenopausal-women-impact-of-estradiol-on-luteinizing-hormone-secretion
#16
Margaret F Lippincott, Yee-Ming Chan, Dianali Rivera Morales, Stephanie B Seminara
Context: Kisspeptin stimulates the reproductive endocrine cascade in both men and women. Circulating sex-steroids are thought to modulate kisspeptin's ability to stimulate GnRH-induced LH release. Objective: To probe the effects of sex steroids on kisspeptin-stimulated GnRH-induced LH pulses. Participants: Eight healthy postmenopausal women. Intervention: Subjects underwent q10 min blood sampling to measure GnRH-induced LH secretion at baseline and in response to a continuous kisspeptin infusion (12...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28359086/the-arcuate-estrogen-regulated-transcriptome-estrogen-response-element-dependent-and-independent-signaling-of-er%C3%AE-in-female-mice
#17
Jennifer A Yang, Hillary Stires, William J Belden, Troy A Roepke
To influence energy homeostasis and reproduction, 17β-estradiol (E2) controls the arcuate nucleus (ARC) through multiple receptor-mediated mechanisms, but primarily via estrogen receptor (ER) α, which signals through both estrogen response element (ERE)-dependent and -independent mechanisms. To determine ERα-mediated, ERE-dependent, and ERE-independent E2 signaling in the ARC, we examined the differential regulation of the mouse arcuate transcriptome by E2 using three mice genotypes: (1) wild-type, (2) ERα knock-in/knockout (ERE-independent mechanisms), and (3) total ERα knockout (ERα-independent mechanisms)...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28359084/genetic-evidence-for-multifactorial-control-of-the-reproductive-axis-in-zebrafish
#18
Yun Liu, Haipei Tang, Rui Xie, Shuisheng Li, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
It is generally believed that kisspeptin and gonadotropin-releasing hormone (GnRH) are required for reproduction in vertebrates. In this study, we generated gnrh3-null zebrafish and found that gnrh3 mutation did not impair gonad development and reproductive capacity. Moreover, zebrafish triple knockout mutant lacking gnrh3 and the 2 kiss1s genes undergo normal puberty and gonad maturation. The expression of follicle-stimulating hormone beta (fshβ) and luteinizing hormone beta (lhβ) was not significantly altered whereas the expression of neuropeptide Y (npy), tachykinin 3 (tac3), and secretogranin-II (sgII) was significantly increased in the triple knockout mutant, suggesting that compensation mechanisms exist to stimulate the reproductive axis in the absence of kiss and gnrh...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28344192/effect-of-investigational-kisspeptin-metastin-analog-tak-683-on-luteinizing-hormone-secretion-at-different-stages-of-the-luteal-phase-in-goats
#19
Larasati Puji Rahayu, Mohammed El Behiry, Natsumi Endo, Tomomi Tanaka
This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an investigational metastin/kisspeptin analog, through treatment during different stages of the luteal phase in goats. Nine cycling Shiba goats (4.4 ± 2.3 years old) were assigned to early luteal phase (ELP, n = 4), mid-luteal phase (MLP, n = 4), and control (n = 5) groups. The ELP and MLP groups were administered 50 µg of TAK-683 intravenously on either day 5 or between days 7-14 after ovulation, respectively...
March 25, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28344041/stat5-signaling-in-kisspeptin-cells-regulates-the-timing-of-puberty
#20
Marina Augusto Silveira, Isadora C Furigo, Thais T Zampieri, Tabata M Bohlen, Daniella G de Paula, Celso Rodrigues Franci, Jose Donato, Renata Frazao
Previous studies have shown that kisspeptin neurons are important mediators of prolactin's effects on reproduction. However, the cellular mechanisms recruited by prolactin to affect kisspeptin neurons remain unknown. Using whole-cell patch-clamp recordings of brain slices from kisspeptin reporter mice, we observed that 20% of kisspeptin neurons in the anteroventral periventricular nucleus was indirectly depolarized by prolactin via an unknown population of prolactin responsive neurons. This effect required the phosphatidylinositol 3-kinase signaling pathway...
March 23, 2017: Molecular and Cellular Endocrinology
keyword
keyword
11905
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"