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https://www.readbyqxmd.com/read/29331017/kv4-channels-to-kisspeptin-neurons-let-s-not-go-steady
#1
Richard Piet
Fertility in all mammals is ultimately controlled by a population of neurons in the ventral forebrain that produce the gonadotropin-releasing hormone (GnRH). This article is protected by copyright. All rights reserved.
January 13, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29325466/the-correlation-between-birth-weight-and-insulin-like-growth-factor-binding-protein-1-igfbp-1-kisspeptin-1-kiss-1-and-three-dimensional-fetal-volume
#2
Gunsu Kimyon Comert, Sertac Esin, Gamze Sinem Caglar, Bulent Yirci, Sedat Ozdemir, Selda Demirtas, Omer Kandemir
PURPOSE: This study aimed to determine the relationship between birth weight, and maternal serum insulin-like growth factor binding protein-1 (IGFBP-1) and kisspeptin-1 (KISS-1) levels, and first-trimester fetal volume (FV) based on three-dimensional ultrasonography. MATERIALS AND METHODS: The study included 142 pregnant women at gestational week 110-136. All fetuses were imaged ultrasonographically by the same physician. Maternal blood samples were collected at the time of ultrasonographic evaluation and analyzed for IGFBP-1 and KISS-1 levels via enzyme-linked immunosorbent assay (ELISA)...
January 11, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29323764/integrative-neuro-humoral-regulation-of-oxytocin-neuron-activity-in-pregnancy-and-lactation
#3
REVIEW
Rachael A Augustine, Alexander J Seymour, Rebecca E Campbell, David R Grattan, Colin H Brown
Oxytocin is required for normal birth and lactation. Oxytocin is synthesised by hypothalamic supraoptic and paraventricular nuclei neurons and is released into the circulation from the posterior pituitary gland. Under basal conditions, circulating oxytocin levels are relatively constant but during birth and lactation, pulsatile oxytocin release triggers rhythmic contraction of the uterus during birth and milk ejection during suckling. Oxytocin levels are principally determined by the pattern of action potential firing that is, in turn, determined by the interplay between the intrinsic properties of the oxytocin neurons, regulation of their excitability by surrounding glia as well as by synaptic drive from their afferent inputs...
January 11, 2018: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/29309558/intergenerational-influence-of-paternal-obesity-on-metabolic-and-reproductive-health-parameters-of-the-offspring-male-preferential-impact-and-involvement-of-kiss1-mediated-pathways
#4
Miguel Angel Sanchez-Garrido, Francisco Ruiz-Pino, Inmaculada Velasco, Alexia Barroso, Daniela Fernandois, Violeta Heras, Maria Manfredi-Lozano, Maria Jesus Vazquez, Juan Manuel Castellano, Juan Roa, Leonor Pinilla, Manuel Tena-Sempere
Obesity and its comorbidities are reaching epidemic proportions worldwide. Maternal obesity is known to predispose the offspring to metabolic disorders, independently of genetic inheritance. This intergenerational transmission has also been suggested for paternal obesity, with a potential negative impact on the metabolic and, eventually, reproductive health of the offspring, likely via epigenetic changes in spermatozoa. However, the neuroendocrine component of such phenomenon and whether paternal obesity sensitizes the offspring to the disturbances induced by high fat diet (HFD) remain poorly defined...
December 22, 2017: Endocrinology
https://www.readbyqxmd.com/read/29307393/kisspeptin-as-a-new-serum-biomarker-to-discriminate-miscarriage-from-viable-intrauterine-pregnancy
#5
Chantae Sullivan-Pyke, Daniel J Haisenleder, Suneeta Senapati, Olivia Nicolais, Esther Eisenberg, Mary D Sammel, Kurt T Barnhart
OBJECTIVE: To validate the ability of serum kisspeptin-54 to discriminate between first-trimester viable pregnancies and miscarriages. DESIGN: Case-control study. SETTING: Academic medical centers. PATIENT(S): Women with confirmed viable intrauterine pregnancy (IUP) at estimated gestational age 6-10 weeks (n = 20), women with confirmed miscarriage (spontaneous abortion [SAB]) at estimated gestational age 6-10 weeks (n = 20), and nonpregnant women (n = 19)...
January 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29303010/the-usefulness-of-circulating-levels-of-leptin-kisspeptin-and-neurokinin-b-in-obese-girls-with-precocious-puberty
#6
Min Jae Kang, Yeon Joung Oh, Young Suk Shim, Joon Woo Baek, Seung Yang, Il Tae Hwang
This study investigated the relationships of circulating leptin, kisspeptin, and neurokinin B (NKB) levels with precocious puberty (PP) in overweight/obese girls and evaluated the usefulness of these markers in the initiation of puberty. One hundred and twenty-eight girls aged 7.0-8.9 years with PP (group A, normal-weight; group B, overweight/obese) and 30 age-matched normal controls (NC) were enrolled. Serum levels of leptin, kisspeptin, and NKB were measured by commercial kits. Serum leptin levels were higher in group A (4...
January 5, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29300923/morphological-analysis-of-the-axonal-projections-of-egfp-labeled-esr1-expressing-neurons-in-transgenic-female-medaka
#7
Buntaro Zempo, Tomomi Karigo, Shinji Kanda, Yasuhisa Akazome, Yoshitaka Oka
Some hypothalamic neurons expressing estrogen receptor α (Esr1) are thought to transmit a gonadal estrogen feedback signal to gonadotropin releasing hormone 1 (GnRH1) neurons, which is the final common pathway for feedback regulation of reproductive functions. Moreover, estrogen-sensitive neurons are suggested to control sexual behaviors in coordination with reproduction. In mammals, hypothalamic estrogen-sensitive neurons release the peptide Kisspeptin and regulate GnRH1 neurons. However, a growing body of evidence in non-mammalian species casts doubt on the regulation of GnRH1 neurons by Kisspeptin neurons...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29298283/kisspeptin-permits-the-sexual-development-of-female-rats-with-normal-and-precocious-puberty-but-is-not-a-trigger-for-it
#8
Wei Song, Kailin Li, Chao Sun, Jiang Xue
OBJECTIVE: We inferred how KISS-1/GPR54 system to involved in precocious puberty by observing hormones level during the process of precocious puberty in model and normal rats during sexual development and the estrus cycle. METHOD: Female rats were divided randomly into CPP and control groups; the former were injected with NMDA twice daily, and control groups were injected with saline. Blood and tissue samples were collected and measured during the stages of prepuberty, vaginal opening, estrus, proestrus and diestrus...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29259493/gamma-aminobutyric-acida-receptor-agonist-muscimol-increases-kiss-1-gene-expression-in-hypothalamic-cell-models
#9
Haruhiko Kanasaki, Tuvshintugs Tumurbaatar, Aki Oride, Tomomi Hara, Hiroe Okada, Satoru Kyo
Purpose: Accumulating evidence indicates that hypothalamic kisspeptin plays a pivotal role in the regulation of the hypothalamic-pituitary-gonadal (HPG) axis. In this study, the direct action of the gamma-aminobutyric acid (GABA)A receptor agonist on kisspeptin-expressing neuronal cells was examined. Methods: A hypothalamic cell model of rat hypothalamic cell line R8 (rHypoE8) cells and primary cultures of neuronal cells from fetal rat brains were stimulated with a potent and selective GABAA receptor agonist, muscimol, to determine the expression of the KiSS-1 gene...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29259492/intra-follicular-kisspeptin-levels-are-related-to-oocyte-maturation-and-gonadal-hormones-in-patients-who-are-undergoing-assisted-reproductive-technology
#10
Yuka Taniguchi, Akira Kuwahara, Ayaka Tachibana, Yuya Yano, Kiyohito Yano, Yuri Yamamoto, Mikio Yamasaki, Takeshi Iwasa, Kenji Hinokio, Toshiya Matsuzaki, Minoru Irahara
Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology. Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels...
October 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29234440/morinda-officinalis-polysaccharides-stimulate-hypothalamic-gnrh-secretion-in-varicocele-progression
#11
Zhu Zhu, Feng Huang, Feng Wang, Yonghong Zhang, Xiaozhen Zhao, Wei Wang
Varicoceles (VCs) are the predominant cause of male infertility and are a risk factor for chronic venous disease. Morinda officinalis (M. officinalis) is a traditional Chinese medicine used to tonify the kidney and strengthen yang. In this study, we evaluated the effects of water-soluble polysaccharides extracted from M. officinalis (MOPs) on gonadotropin-release hormone (GnRH) secretion in a classic experimental left VC (ELV) rat model. Intragastric administration of MOPs at a dose ranging from 50 mg kg-1 to 100 mg kg-1 facilitated improvements in sperm parameters and seminiferous epithelial structures, modulated serum hormone profiles, and stimulated GnRH synthesis and release in the hypothalamus...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29229849/obligatory-role-of-hypothalamic-neuroestradiol-during-the-estrogen-induced-lh-surge-in-female-ovariectomized-rhesus-monkeys
#12
Brian P Kenealy, Kim L Keen, James P Garcia, Lucille K Kohlenberg, Ei Terasawa
Negative and positive feedback effects of ovarian 17β-estradiol (E2) regulating release of gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH) are pivotal events in female reproductive function. While ovarian feedback on hypothalamo-pituitary function is a well-established concept, the present study shows that neuroestradiol, locally synthesized in the hypothalamus, is a part of estrogen's positive feedback loop. In experiment 1, E2 benzoate-induced LH surges in ovariectomized female monkeys were severely attenuated by systemic administration of the aromatase inhibitor, letrozole...
December 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29223677/the-hypothalamus-pituitary-gonad-axis-tales-of-mice-and-men
#13
REVIEW
Athina Kaprara, Ilpo T Huhtaniemi
Reproduction is controlled by the hypothalamic - pituitary - gonadal (HPG) axis. Gonadotropin-releasing hormone (GnRH) neurons play a central role in this axis through production of GnRH, which binds to a membrane receptor on pituitary gonadotrophs and stimulates the biosynthesis and secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Multiple factors affect GnRH neuron migration, GnRH gene expression, GnRH pulse generator, GnRH secretion, GnRH receptor expression, and gonadotropin synthesis and release...
December 6, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29223284/daily-rhythms-count-for-female-fertility
#14
REVIEW
Valérie Simonneaux, Thibault Bahougne, Eleni Angelopoulou
Female ovulation depends on a surge in circulating luteinizing hormone (LH) which occurs at the end of the resting period and requests high circulating estradiol. This fine tuning involves both an estradiol feedback as an indicator of oocyte maturation, and the master circadian clock of the suprachiasmatic nuclei as an indicator of the time of the day. This review describes the mechanisms through which daily time cues are conveyed to reproductive hypothalamic neurons to time the pre-ovulatory surge. In female rodents, neurotransmitters released by the suprachiasmatic nuclei activate the stimulatory kisspeptin neurons and reduce the inhibitory RFRP neurons precisely at the end of the afternoon of proestrus to allow a full surge in LH secretion...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29214635/kv4-2-channel-activity-controls-intrinsic-firing-dynamics-of-arcuate-kisspeptin-neurons
#15
Philipe R F Mendonça, Victoria Kyle, Shel-Hwa Yeo, William H Colledge, Hugh P C Robinson
Kisspeptin neurons in the hypothalamus are critically involved in reproductive function, via their effect on GnRH neuron activity and consequent gonadotropin release. Kisspeptin neurons show an intrinsic irregularity of firing, but the mechanism of this remains unclear. To address this, we carried out targeted whole-cell patch-clamp recordings of kisspeptin neurons in the arcuate nucleus (Kiss1Arc ), in brain slices isolated from adult male Kiss-Cre:tdTomato mice. Cells fired irregularly in response to constant current stimuli, with a wide range of spike time variability, and prominent subthreshold voltage fluctuations...
December 6, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#16
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29206176/kisspeptin-10-induces-%C3%AE-casein-synthesis-via-gpr54-and-its-downstream-signaling-pathways-in-bovine-mammary-epithelial-cells
#17
Jianhua Sun, Juxiong Liu, Bingxu Huang, Xingchi Kan, Guangxin Chen, Wei Wang, Shoupeng Fu
Kisspeptins (Kps) play a key role in the regulation of GnRH axis and as an anti-metastasis agent by binding with GPR54. Recently, we observed that the expression of GPR54 was higher in the lactating mammary tissues of dairy cows with high-quality milk (0.81 ± 0.13 kg/day of milk protein yield; 1.07 ± 0.18 kg/day of milk fat yield) than in those with low-quality milk (0.51 ± 0.14 kg/day of milk protein yield; 0.67 ± 0.22 kg/day of milk fat yield). We hypothesized that Kp-10 might regulate the milk protein, β-casein (CSN2) synthesis via GPR54 and its downstream signaling...
December 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29203206/expression-of-hypothalamic-kisspeptin-neurokinin-b-and-dynorphin-a-neurons-attenuates-in-female-zucker-fatty-rats
#18
Kimihiko Nakao, Kinuyo Iwata, Toshiyuki Takeshita, Hitoshi Ozawa
Zucker fatty (ZF) rats are considered to be an obese model due to leptin receptor abnormality and such rats show infertility. Pulsatile gonadotropin-releasing hormone/luteinizing hormone (LH) secretion, which is important for follicular development in females, is considered to be controlled by KNDy neurons coexpressing kisspeptin, neurokinin B (NKB), and dynorphin A (DynA), encoded by Kiss1, Tac3, and Pdyn, respectively, in the hypothalamic arcuate nucleus (ARC). The purpose of this study is to examine the expression of KNDy neurons in female ZF rats by histochemical approach because pulsatile LH secretion is suppressed...
December 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29203140/coordination-or-coincidence-the-relationship-between-prolactin-and-gonadotropin-secretion
#19
David R Grattan
A recent paper demonstrates that kisspeptin can stimulate the secretion of both prolactin and luteinizing hormone (LH). This provides novel insight into mechanisms that could account for previous observations of concordant patterns of secretion of the two hormones, such as pulsatile secretion with simultaneous pulses, as well as the preovulatory surges of both prolactin and LH.
December 1, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29201072/the-role-of-kisspeptin-in-female-reproduction
#20
REVIEW
Sareh Zeydabadi Nejad, Fahimeh Ramezani Tehrani, Azita Zadeh-Vakili
Context: Kisspeptin (KISS1), a recently discovered neuropeptide that acts upstream of gonadotropin-releasing hormone (GnRH) neurons, is critical for maturation and function of the reproductive axis. This review aimed at providing comprehensive and up-to-date information on Kisspeptin and its role in female reproduction. Evidence Acquisition: A literature review was performed using PubMed for all English language articles published between 1999 and 2016. Results: The kisspeptin system (KISS1/G protein-coupled receptor-54,GPR54) has recently been addressed as an essential gatekeeper of puberty onset and gonadotropin secretion...
July 2017: International Journal of Endocrinology and Metabolism
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