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Arginine topical

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https://www.readbyqxmd.com/read/29159695/a-novel-lignin-based-nanofibrous-dressing-containing-arginine-for-wound-healing-applications
#1
Fatemeh Reesi, Mohsen Minaiyan, Azade Taheri
Nanofiber-based wound dressings have attracted much attention in wound care owing to their unique properties such as high aspect ratio and three-dimensional structure. Arginine is a precursor of nitric oxide that plays an important role in the wound-healing process. Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel). The effect of pH on the amount of arginine attached on Lig-NF surface was evaluated at three different pH values-5, 6, and 7...
November 20, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28910080/cell-surface-interactions-on-arginine-rich-cell-penetrating-peptides-allow-for-multiplex-modes-of-internalization
#2
Shiroh Futaki, Ikuhiko Nakase
One of the recent hot topics in peptide-related chemical biology research is the potential of cell-penetrating peptides (CPPs). Owing to their ability to deliver exogenous molecules into cells easily and effectively, their flexible design that allows transporters to comprise various chemical structures and functions, and their potential in chemical and cell biology studies and clinical applications, CPPs have been attracting enormous interest among researchers in related fields. Consequently, publications on CPPs have increased significantly...
October 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28769868/hydrogen-sulfide-mediating-both-excitatory-and-inhibitory-effects-in-a-rat-model-of-meningeal-nociception-and-headache-generation
#3
Christiane Teicher, Roberto De Col, Karl Messlinger
BACKGROUND/PURPOSE: Hydrogen sulfide (H2S) is a neuromodulator acting through nitroxyl (HNO) when it reacts with nitric oxide (NO). HNO activates transient receptor potential channels of the ankyrin type 1 (TRPA1) causing release of calcitonin gene-related peptide from primary afferents. Activation of meningeal nociceptors projecting to the human spinal trigeminal nucleus (STN) may lead to headaches. In a rat model of meningeal nociception, the activity of spinal trigeminal neurons was used as read-out for the interaction between H2S and NO...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28708224/carbonic-anhydrase-inhibitor-with-topical-nsaid-therapy-to-manage-cystoid-macular-edema-in-a-case-of-gyrate-atrophy
#4
Elena Piozzi, Salvatore Alessi, Silvia Santambrogio, Giovanni Cillino, Marco Mazza, Aissa Iggui, Salvatore Cillino
PURPOSE: Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern. CASE REPORT: We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME)...
July 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28664267/transdermally-administered-proline-arginine-rich-host-defense-peptides-show-systemic-efficacy-in-a-lethal-mouse-bacteremia-model
#5
Eszter Ostorhazi, Andrea Horvath, Dora Szabo, Laszlo Otvos
Host defense peptides are preferably administered as topical therapeutic agents. We have investigated whether peptide A3-APO can enter the circulation when applied to the ear skin. Efficacy of peptide monotherapy as transdermal administration option was assessed in a systemic mouse Acinetobacter baumannii model. A3-APO reduced mortality and demonstrated a statistically significant reduction of blood bacterial counts, regardless whether it was administered prior or after bacterial challenge. The peptidic metabolite of A3-APO was efficacious when applied to the ear or tail...
June 29, 2017: Amino Acids
https://www.readbyqxmd.com/read/28618757/the-effect-of-acetylsalicylic-acid-on-vasopressin-serum-insulin-levels-insulin-resistance-and-biochemical-parameters-in-rats-induced-with-experimental-diabetes-type-2
#6
Serkan Şen, Sefa Çelik
BACKGROUND/AIM: Acetylsalicylic acid (ASA) treatment in diabetic patients is very important owing to the increasing hyperactivity of thrombocytes and atherosclerosis. In several investigations, it was reported that diabetes caused increased coronary artery disease, cerebrovascular disease, and death. In this study, we aimed to investigate the effect of ASA on osmoregulation, glycemic control, and some biochemical parameters in rats induced with experimental diabetes type 2. MATERIALS AND METHODS: Twenty-four rats were randomly divided in four groups: control (I), ASA control (II), diabetic (III), and ASA diabetic (IV)...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28603971/enhanced-and-prolonged-cell-penetrating-abilities-of-arginine-rich-peptides-by-introducing-cyclic-%C3%AE-%C3%AE-disubstituted-%C3%AE-amino-acids-with-stapling
#7
Makoto Oba, Masayuki Kunitake, Takuma Kato, Atsushi Ueda, Masakazu Tanaka
Cell-penetrating peptides are receiving increasing attention as drug delivery tools, and the search for peptides with high cell-penetrating ability and negligible cytotoxicity has become a critical research topic. Herein, cyclic α,α-disubstituted α-amino acids were introduced into arginine-rich peptides and an additional staple was provided in the side chain. The peptides designed in the present study showed more enhanced and prolonged cell-penetrating abilities than an arginine nonapeptide due to high resistance to protease and conformationally stable helical structures...
July 19, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28531982/study-of-the-keratin-based-therapeutic-dermal-patches-for-the-delivery-of-bioactive-molecules-for-wound-treatment
#8
Kush Kumar Nayak, Pratima Gupta
In the present study, dressing materials were fabricated in the form of dermal patches. The keratin based biocompatible materials, namely Keratin/Alginate, Keratin/Agar, and Keratin/Gellan were developed as therapeutic dermal patches. The patches were coated with green synthesized silver nanoparticles to prevent the microbial infection and were found to be antimicrobial against pathogens. Papain was used in the patches to acquire the enzymatic cell debridement and its activity was measured by reduction rate of benzoyl-l-arginine ethyl ester...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28450192/do-the-accelerating-actions-of-tianeptine-and-l-arginine-on-cortical-spreading-depression-interact-an-electrophysiological-analysis-in-young-and-adult-rats
#9
Luciana Maria Silva de Seixas Maia, Angela Amancio-Dos-Santos, Paula Catirina Pereira da Silva Germano, Anna Carolina Santos Marinho Falcão, Desirré Duda-de-Oliveira, Rubem Carlos Araújo Guedes
In the rat, we previously demonstrated that serotonin-enhancing drugs impair cortical spreading depression (CSD) and that l-arginine (arginine) treatment enhances CSD. Here, we investigated the interaction between topical application of the serotonin uptake enhancer tianeptine and systemic arginine administration on CSD. From postnatal day 7-28, female Wistar rats (n=40) received by gavage 300mg/Kg/day arginine (n=20) or water (n=20). Half of the arginine- or water-treated rats underwent CSD recording at 30-40days of age (young), while the other half was recorded at 90-120days (adult)...
April 25, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28414134/targeted-intracorneal-delivery-biodistribution-of-triamcinolone-acetonide-following-topical-iontophoresis-of-cationic-amino-acid-ester-prodrugs
#10
Verena Santer, Sergio Del Río Sancho, Maria Lapteva, Yogeshvar N Kalia
The aim was to investigate intracorneal iontophoresis of biolabile triamcinolone acetonide (TA) amino acid ester prodrugs (TA-AA). Arginine and lysine esters of TA (TA-Arg and TA-Lys, respectively) were synthesized and characterized; quantification was performed by HPLC-UV and UHPLC-MS/MS. The aqueous solubility of the prodrugs (at pH 5.5) was ∼1000-fold greater than TA. Anodal iontophoresis (10min at 3mA/cm(2)) of TA-AA was investigated using isolated porcine cornea. Although no statistically significant difference was observed in total intracorneal delivery of TA (468...
April 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28260884/topical-ocular-delivery-to-laser-induced-choroidal-neovascularization-by-dual-internalizing-rgd-and-tat-peptide-modified-nanoparticles
#11
Yongchao Chu, Ning Chen, Huajun Yu, Hongjie Mu, Bin He, Hongchen Hua, Aiping Wang, Kaoxiang Sun
A nanoparticle (NP) was developed to target choroidal neovascularization (CNV) via topical ocular administration. The NPs were prepared through conjugation of internalizing arginine-glycine-aspartic acid RGD (iRGD; Ac-CCRGDKGPDC) and transactivated transcription (TAT) (RKKRRQRRRC) peptide to polymerized ethylene glycol and lactic-co-glycolic acid. The iRGD sequence can specifically bind with integrin αvβ3, while TAT facilitates penetration through the ocular barrier. (1)H nuclear magnetic resonance and high-performance liquid chromatography demonstrated that up to 80% of iRGD and TAT were conjugated to poly(ethylene glycol)- poly(lactic-co-glycolic acid)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28181841/surface-density-of-polyarginine-influence-the-size-zeta-potential-cellular-uptake-and-tissue-distribution-of-the-nanostructured-lipid-carrier
#12
COMPARATIVE STUDY
Mingshuang Sun, Zhihong Zhu, Huixin Wang, Cuiyan Han, Dandan Liu, Lei Tian, Xinggang Yang, Weisan Pan
Poly-arginines are strong tools to elevate the cellular uptake of nanopreparations. To learn the influence of poly-arginine (RRRRRRRR, R8) density on a series of properties of nanostructured lipid carrier (NLC), we build six R8 modified NLCs with different R8 densities (nR-NLC, where n represents the R8 ratio) by fusion-emulsion method with the aid of stearyl-R8. The pharmaceutical characteristics like size, zeta potential and in vitro drug release, cellular uptake, cytotoxicity to A549 cells and tissue distribution in S180 tumor-bearing mice of the six nR-NLCs are all investigated...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28135068/development-of-potent-selective-srpk1-inhibitors-as-potential-topical-therapeutics-for-neovascular-eye-disease
#13
Jennifer Batson, Hamish D Toop, Clara Redondo, Roya Babaei-Jadidi, Apirat Chaikuad, Stephen F Wearmouth, Brian Gibbons, Claire Allen, Cynthia Tallant, Jingxue Zhang, Chunyun Du, Jules C Hancox, Tom Hawtrey, Joana Da Rocha, Renate Griffith, Stefan Knapp, David O Bates, Jonathan C Morris
Serine/arginine-protein kinase 1 (SRPK1) regulates alternative splicing of VEGF-A to pro-angiogenic isoforms and SRPK1 inhibition can restore the balance of pro/antiangiogenic isoforms to normal physiological levels. The lack of potency and selectivity of available compounds has limited development of SRPK1 inhibitors, with the control of alternative splicing by splicing factor-specific kinases yet to be translated. We present here compounds that occupy a binding pocket created by the unique helical insert of SRPK1, and trigger a backbone flip in the hinge region, that results in potent (<10 nM) and selective inhibition of SRPK1 kinase activity...
March 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/27934650/parenteral-or-enteral-arginine-supplementation-safety-and-efficacy
#14
REVIEW
Martin D Rosenthal, Phillip W Carrott, Jayshil Patel, Laszlo Kiraly, Robert G Martindale
Arginine supplementation has the potential to improve the health of patients. Its use in hospitalized patients has been a controversial topic in the nutrition literature, especially concerning supplementation of septic patients. In this article, we review the relevant literature both for and against the use of arginine in critically ill, surgical, and hospitalized patients. The effect of critical illness on arginine metabolism is reviewed, as is its use in septic and critically ill patients. Although mounting evidence supports immunonutrition, there are only a few studies that suggest that this is safe in patients with severe sepsis...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27825863/comparison-of-liposomal-and-nlc-nanostructured-lipid-carrier-formulations-for-improving-the-transdermal-delivery-of-oxaprozin-effect-of-cyclodextrin-complexation
#15
COMPARATIVE STUDY
N Mennini, M Cirri, F Maestrelli, P Mura
The combined strategy of drug-cyclodextrin (CD) complexation and complex loading into nanocarriers (deformable liposomes or nanostructured lipid carriers (NLC)), was exploited to develop effective topical formulations for oxaprozin transdermal administration. Oxaprozin was loaded as ternary complex with randomly-methylated-ßCD and arginine, selected as the best system in improving drug solubility. The colloidal dispersions, characterized for particle size, zeta-potential and entrapment efficiency, were investigated for drug permeation properties in comparison with a plain drug aqueous suspension, a ternary complex aqueous solution and a plain drug liposomal or NLC dispersion...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27743199/arginine-silicate-inositol-complex-accelerates-cutaneous-wound-healing
#16
Ali Said Durmus, Mehmet Tuzcu, Oguzhan Ozdemir, Cemal Orhan, Nurhan Sahin, Ibrahim Hanifi Ozercan, James Richard Komorowski, Shakir Ali, Kazim Sahin
Arginine silicate inositol (ASI) complex is a composition of arginine, silicon, and inositol that has been shown to have beneficial effects on vascular health. This study reports the effects of an ASI ointment on wound healing in rats. A full-thickness excision wound was created by using a disposable 5 mm diameter skin punch biopsy tool. In this placebo-controlled study, the treatment group's wound areas were covered by 4 or 10 % ASI ointments twice a day for 5, 10, or 15 days. The rats were sacrificed either 5, 10, or 15 days after the wounds were created, and biopsy samples were taken for biochemical and histopathological analysis...
May 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/27737343/oral-or-topical-administration-of-l-arginine-changes-the-expression-of-tgf-and-inos-and-results-in-early-wounds-healing
#17
Márcio Sousa Jerônimo, Adria do Prado Barros, Vinícius Elord Zen MoritaI, Erika Oliveira Alves, Nathalia Lobão Barroso de Souza, Rosane Mansan de Almeida, Yanna Karla Medeiros Nóbrega, Florêncio Figueiredo Cavalcanti, Rivadávio Amorin, Maria de Fátima Borin, Anamélia Lorenzetti Bocca
PURPOSE: To evaluate the contribution of L-arginine oral or topical rout of administration in the surgical wound healing process. METHODS: L-arginine was orally or topically administrated to mice after a laparotomy model procedure. The wounds were analyzed to evaluate the granulation tissue by HE analysis, collagen deposition, iNOS and cytokines production by immunochemisyry on wound progress. Mice used in this model were healthy, immunosupressed or diabetic and all of them were treated with different concentration of L-arginine and rout of administration...
September 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27651809/effects-of-topical-and-systemic-administration-of-eugenia-caryophyllata-buds-essential-oil-on-corneal-anesthesia-and-analgesia
#18
Emad Khalilzadeh, Reza Hazrati, Gholamreza Vafaei Saiah
Clinical studies suggest that essential oil of Eugenia caryophyllata (Clove) buds (EOEC) is efficacious in the treatment of dental pain. In the present study, we investigated the analgesic and local anesthetic effects of EOEC and its possible mechanisms of action in acute corneal pain in rats. EOEC was extracted by hydro-distillation in a Clevenger type apparatus from clove buds. The acute corneal pain was induced by applying a drop (40 µl) of 5 M NaCl solution on the corneal surface, and the numbers of eye wipes were counted during the first 30 s...
July 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27579336/protein-transduction-therapy-into-cochleae-via-the-round-window-niche-in-guinea-pigs
#19
Hiroki Takeda, Takaomi Kurioka, Taku Kaitsuka, Kazuhito Tomizawa, Takeshi Matsunobu, Farzana Hakim, Kunio Mizutari, Toru Miwa, Takao Yamada, Momoko Ise, Akihiro Shiotani, Eiji Yumoto, Ryosei Minoda
Cell-penetrating peptides (CPPs) are short sequences of amino acids that facilitate the penetration of conjugated cargoes across mammalian cell membranes, and as such, they may provide a safe and effective method for drug delivery to the inner ear. Simple polyarginine peptides have been shown to induce significantly higher cell penetration rates among CPPs. Herein, we show that a peptide consisting of nine arginines ("9R") effectively delivered enhanced green fluorescent protein (EGFP) into guinea pig cochleae via the round window niche without causing any deterioration in auditory function...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27405275/evaluation-of-short-synthetic-antimicrobial-peptides-for-treatment-of-drug-resistant-and-intracellular-staphylococcus-aureus
#20
Mohamed F Mohamed, Ahmed Abdelkhalek, Mohamed N Seleem
Methicillin-resistant Staphylococcus aureus (MRSA) infections present a serious challenge because of the emergence of resistance to numerous conventional antibiotics. Due to their unique mode of action, antimicrobial peptides are novel alternatives to traditional antibiotics for tackling the issue of bacterial multidrug resistance. Herein, we investigated the antibacterial activity of two short novel peptides (WR12, a 12 residue peptide composed exclusively of arginine and tryptophan, and D-IK8, an eight residue β-sheet peptide) against multidrug resistant staphylococci...
July 11, 2016: Scientific Reports
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