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https://www.readbyqxmd.com/read/28818377/heterologous-expression-of-gmsip1-3-from-soybean-in-tobacco-showed-and-growth-retardation-and-tolerance-to-hydrogen-peroxide
#1
Dayong Zhang, Yihong Huang, Manoj Kumar, Qun Wan, Zhaolong Xu, Hongbo Shao, Girdhar K Pandey
Aquaporins (AQPs) are transmembrane protein channels that are members of Major Intrinsic Proteins (MIP) superfamily. AQPs play important roles in plant reproduction, cell elongation, osmoregulation, influence leaf physiology and are responsive to drought and salt tolerance. Small intrinsic proteins (SIPs)belongs to one of the groups of AQPs, which are mainly localized to endoplasmic reticulum(ER). While this group of aquaporin is being well studied in Arabidopsis, grape and other plant species, not much is known about the molecular regulatory mechanisms driven by ER-type AQPs in Glycine Max...
October 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28647685/irtks-is-correlated-with-progression-and-survival-time-of-patients-with-gastric-cancer
#2
Li-Yu Huang, Xuefei Wang, Xiao-Fang Cui, He Li, Junjie Zhao, Chong-Chao Wu, Lingqiang Min, Zhicheng Zhou, Lixin Wan, Yu-Ping Wang, Chao Zhang, Wei-Qiang Gao, Yihong Sun, Ze-Guang Han
BACKGROUND AND OBJECTIVES: IRTKS functions as a novel regulator of tumour suppressor p53; however, the role of IRTKS in pathogenesis of gastric cancer is unclear. DESIGN: We used immunohistochemistry to detect IRTKS levels in 527 human gastric cancer specimens. We generated both IRTKS-deficient and p53-deficient mice to observe survival time of these mice and to isolate mouse embryonic fibroblasts (MEFs) for evaluating in vivo tumorigenicity. Co-immunoprecipitation was used to study the interaction among p53, MDM2 and IRTKS, as well as the ubiquitination of p53...
June 24, 2017: Gut
https://www.readbyqxmd.com/read/28591574/mtor-inhibition-subdues-milk-disorder-caused-by-maternal-vldlr-loss
#3
HoangDinh Huynh, Wei Wei, Yihong Wan
It is unknown whether and how very-low density lipoprotein receptors (VLDLRs) impact skeletal homeostasis. Here, we report that maternal and offspring VLDLRs play opposite roles in osteoclastogenesis and bone resorption. VLDLR deletion in the offspring augments osteoclast differentiation by enhancing RANKL signaling, leading to osteoporosis. In contrast, VLDLR deletion in the mother alters milk metabolism, which inhibits osteoclast differentiation and causes osteopetrosis in the offspring. The maternal effects are dominant...
June 6, 2017: Cell Reports
https://www.readbyqxmd.com/read/28563903/high-contrast-fluorescence-detection-of-metastatic-breast-cancer-including-bone-and-liver-micrometastases-via-size-controlled-ph-activatable-water-soluble-probes
#4
Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, Daniel J Siegwart
Breast cancer metastasis is the major cause of cancer death in women worldwide. Early detection would save many lives, but current fluorescence imaging probes are limited in their detection ability, particularly of bone and liver micrometastases. Herein, probes that are capable of imaging tiny (<1 mm) micrometastases in the liver, lung, pancreas, kidneys, and bone, that have disseminated from the primary site, are reported. The influence of the poly(ethylene glycol) (PEG) chain length on the performance of water-soluble, pH-responsive, near-infrared 4,4'-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) probes is systematically investigated to demonstrate that PEG tuning can provide control over micrometastasis tracking with high tumor-to-background contrast (up to 12/1)...
May 31, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28527581/nuclear-receptors-in-skeletal-homeostasis
#5
Hao Zuo, Yihong Wan
Nuclear receptors are a family of transcription factors that can be activated by lipophilic ligands. They are fundamental regulators of development, reproduction, and energy metabolism. In bone, nuclear receptors enable bone cells, including osteoblasts, osteoclasts, and osteocytes, to sense their dynamic microenvironment and maintain normal bone development and remodeling. Our views of the molecular mechanisms in this process have advanced greatly in the past decade. Drugs targeting nuclear receptors are widely used in the clinic for treating patients with bone disorders such as osteoporosis by modulating bone formation and resorption rates...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28049847/gpr132-sensing-of-lactate-mediates-tumor-macrophage-interplay-to-promote-breast-cancer-metastasis
#6
Peiwen Chen, Hao Zuo, Hu Xiong, Matthew J Kolar, Qian Chu, Alan Saghatelian, Daniel J Siegwart, Yihong Wan
Macrophages are prominent immune cells in the tumor microenvironment that exert potent effects on cancer metastasis. However, the signals and receivers for the tumor-macrophage communication remain enigmatic. Here, we show that G protein-coupled receptor 132 (Gpr132) functions as a key macrophage sensor of the rising lactate in the acidic tumor milieu to mediate the reciprocal interaction between cancer cells and macrophages during breast cancer metastasis. Lactate activates macrophage Gpr132 to promote the alternatively activated macrophage (M2)-like phenotype, which, in turn, facilitates cancer cell adhesion, migration, and invasion...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27967239/lipid-osteoclastokines-regulate-breast-cancer-bone-metastasis
#7
Jing Y Krzeszinski, Adam G Schwaid, Wing Yin Cheng, Zixue Jin, Zachary R Gallegos, Alan Saghatelian, Yihong Wan
Bone metastasis is a deadly consequence of cancers, in which osteoclast forms a vicious cycle with tumor cells. Bone metastasis attenuation by clinical usage of osteoclast inhibitors and in our osteopetrotic mouse genetic models with β-catenin constitutive activation or peroxisome proliferator-activated receptor γ deficiency fully support the important role of osteoclast in driving the bone metastatic niche. However, the mechanisms for this "partnership in crime" are underexplored. Here we show that osteoclasts reprogram their lipid secretion to support cancer cells...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/27886052/a-melting-curve-based-multiplex-rt-qpcr-assay-for-simultaneous-detection-of-four-human-coronaviruses
#8
Zhenzhou Wan, Ya'nan Zhang, Zhixiang He, Jia Liu, Ke Lan, Yihong Hu, Chiyu Zhang
Human coronaviruses HCoV-OC43, HCoV-229E, HCoV-NL63 and HCoV-HKU1 are common respiratory viruses associated with acute respiratory infection. They have a global distribution. Rapid and accurate diagnosis of HCoV infection is important for the management and treatment of hospitalized patients with HCoV infection. Here, we developed a melting curve-based multiplex RT-qPCR assay for simultaneous detection of the four HCoVs. In the assay, SYTO 9 was used to replace SYBR Green I as the fluorescent dye, and GC-modified primers were designed to improve the melting temperature (Tm) of the specific amplicon...
November 23, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27863398/unique-epigenetic-gene-profiles-define-human-breast-cancers-with-poor-prognosis
#9
Samuel Peña-Llopis, Yihong Wan, Elisabeth D Martinez
Epigenetic enzymes are at the nexus of cellular regulatory cascades and can drive cancer-specific deregulation at all stages of the oncogenic process, yet little is known about their prognostic value in human patients. Here, we used qRT-PCR to profile at high resolution the expression of fifty-five epigenetic genes in over one hundred human breast cancer samples and patient-matched benign tissues. We correlated expression patterns with clinical and histological parameters and validated our findings in two independent large patient cohorts (TCGA and METABRIC)...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27824815/reply-to-ppar-%C3%AE-regulates-pharmacological-but-not-physiological-or-pathological-osteoclast-formation
#10
Ronald M Evans, Yihong Wan
No abstract text is available yet for this article.
November 8, 2016: Nature Medicine
https://www.readbyqxmd.com/read/27762598/identification-of-two-new-hiv-1-circulating-recombinant-forms-crf87_cpx-and-crf88_bc-from-reported-unique-recombinant-forms-in-asia
#11
Yihong Hu, Zhenzhou Wan, Yan-Heng Zhou, Davey Smith, Yong-Tang Zheng, Chiyu Zhang
The on-going generation of HIV-1 intersubtype recombination has led to new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) in Asia. In this study, we evaluated whether previously reported URFs were actually CRFs. All available complete or near full-length HIV-1 URF sequences from Asia were retrieved from the HIV Los Alamos National Laboratory Sequence database, and phylogenetic, transmission cluster, and bootscan analyses were performed using MEGA 6.0, Cluster Picker 1.2.1, and SimPlot3...
April 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27692066/macrophage-ppar%C3%AE-inhibits-gpr132-to-mediate-the-anti-tumor-effects-of-rosiglitazone
#12
Wing Yin Cheng, HoangDinh Huynh, Peiwen Chen, Samuel Peña-Llopis, Yihong Wan
Tumor-associated macrophage (TAM) significantly contributes to cancer progression. Human cancer is enhanced by PPARγ loss-of-function mutations, but inhibited by PPARγ agonists such as TZD diabetes drugs including rosiglitazone. However, it remains enigmatic whether and how macrophage contributes to PPARγ tumor-suppressive functions. Here we report that macrophage PPARγ deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, we identify Gpr132 as a novel direct PPARγ target in macrophage whose expression is enhanced by PPARγ loss but repressed by PPARγ activation...
October 3, 2016: ELife
https://www.readbyqxmd.com/read/27464760/microrna-exert-macro-effects-on-cancer-bone-metastasis
#13
REVIEW
Scott R Baier, Yihong Wan
Bone metastasis is a deadly complication of cancers arising from many different primary tumor locations. Cross talk between cancer and bone cells is a well-established driver of bone metastasis, and recent work reveals microRNA (miRNA) as key players in this communication. Functional significance of miRNA was first demonstrated in cancer cells and has now also been documented in bone cell differentiation and skeletal remodeling. Review of recent literature highlights how different miRNAs can impact each step of the metastatic process by acting in both tumor and the metastatic niche to exert pleiotropic effects...
October 2016: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/27451264/a-novel-real-time-reverse-transcription-polymerase-chain-reaction-assay-with-partially-double-stranded-linear-dna-probe-for-sensitive-detection-of-hepatitis-c-viral-rna
#14
Tianfu Liu, Zhenzhou Wan, Jia Liu, Lingyi Zhang, Yanheng Zhou, Ke Lan, Yihong Hu, Chiyu Zhang
The detection and quantification of HCV RNA is very helpful for the management and treatment of HCV related diseases. Detection of low HCV viral load is a great challenge in HCV RNA detection. Here, we developed a novel real-time RT-PCR assay with partially double-stranded linear DNA probe which can detect all HCV genotypes and improve the detection performance. The novel assay has a wide linear dynamic range of HCV RNA quantification (1×10(2)-1×10(11)IU/ml) and a limit of detection of 78IU/ml. The assay exhibits an excellent reproducibility with 2...
October 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27335162/genome-wide-characterization-of-the-ankyrin-repeats-gene-family-under-salt-stress-in-soybean
#15
Dayong Zhang, Qun Wan, Xiaolan He, Lihua Ning, Yihong Huang, Zhaolong Xu, Jia Liu, Hongbo Shao
Ankyrin repeats (ANK) gene family are common in diverse organisms and play important roles in cell growth, development and response to environmental stresses. Recently, genome-wide identification and evolutionary analyses of the ANK gene family have been carried out in Arabidopsis, rice and maize. However, little is known about the ANK genes in the whole soybean genome. In this study, we described the identification and structural characterization of 162ANK genes in soybean (GmANK). Then, comprehensive bioinformatics analyses of GmANK genes family were performed including gene locus, phylogenetic, domain composition analysis, chromosomal localization and expression profiling...
October 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27047508/soybean-c2h2-type-zinc-finger-protein-gmzfp3-with-conserved-qalggh-motif-negatively-regulates-drought-responses-in-transgenic-arabidopsis
#16
Dayong Zhang, Jinfeng Tong, Zhaolong Xu, Peipei Wei, Ling Xu, Qun Wan, Yihong Huang, Xiaolan He, Jiayin Yang, Hongbo Shao, Hongxiang Ma
Plant response to environmental stresses is regulated by a complicated network of regulatory and functional genes. In this study, we isolated the putative stress-associated gene GmZFP3 (a C2H2-type Zinc finger protein gene) based on the previous finding that it was one of two genes located in the QTL region between the Satt590 and Satt567 markers related to soybean tolerance to drought. Temporal and spatial expression analysis using quantitative real-time PCR indicated that GmZFP3 was primarily expressed in roots, stems and leaf organs and was expressed at low levels in flowers and soybean pods...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27039704/use-of-a-steady-state-baseline-to-address-evoked-vs-oscillation-models-of-visual-evoked-potential-origin
#17
Minpeng Xu, Yihong Jia, Hongzhi Qi, Yong Hu, Feng He, Xin Zhao, Peng Zhou, Lixin Zhang, Baikun Wan, Wei Gao, Dong Ming
There has been a long debate about the neural mechanism of event-related potentials (ERPs). Previously, no evidence or method was apparent to validate the two competing models, the evoked model and the oscillation model. One argument is whether the pre-stimulus brain oscillation could influence the following ERP. This study carried out an innovative visual oddball task experiment to investigate the dynamic process of visual evoked potentials. A period of stable oscillations of specified dominant frequencies and initial phases, i...
July 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/26812161/gata2-is-a-rheostat-for-mesenchymal-stem-cell-fate-in-male-mice
#18
Xiaoxiao Li, HoangDinh Huynh, Hao Zuo, Marjo Salminen, Yihong Wan
Gata2 is a zinc finger transcription factor that is important in hematopoiesis and neuronal development. However, the roles of Gata2 in the mesenchymal lineages are poorly understood. In vitro studies suggest that Gata2 modulates adipocyte differentiation and mesenchymal stem cell (MSC) proliferation. To systematically determine the in vivo functions of Gata2 in the MSC lineage commitment and development, we have generated three mouse models in which Gata2 is specifically deleted in MSCs, adipocytes, or osteoblasts...
March 2016: Endocrinology
https://www.readbyqxmd.com/read/26777690/ligand-activation-of-err%C3%AE-by-cholesterol-mediates-statin-and-bisphosphonate-effects
#19
Wei Wei, Adam G Schwaid, Xueqian Wang, Xunde Wang, Shili Chen, Qian Chu, Alan Saghatelian, Yihong Wan
Nuclear receptors (NRs) are key regulators of gene expression and physiology. Nearly half of all human NRs lack endogenous ligands including estrogen-related receptor α (ERRα). ERRα has important roles in cancer, metabolism, and skeletal homeostasis. Affinity chromatography of tissue lipidomes with the ERRα ligand-binding domain (LBD) and subsequent transcriptional assays identified cholesterol as an endogenous ERRα agonist. Perturbation of cholesterol biosynthesis or inhibition of ERRα revealed the interdependence of cholesterol and ERRα...
March 8, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/26456333/a-liver-bone-endocrine-relay-by-igfbp1-promotes-osteoclastogenesis-and-mediates-fgf21-induced-bone-resorption
#20
Xunde Wang, Wei Wei, Jing Y Krzeszinski, Yubao Wang, Yihong Wan
Fibroblast growth factor 21 (FGF21) promotes insulin sensitivity but causes bone loss. It elevates bone resorption by an undefined non-osteoclast-autonomous mechanism. We have detected a pro-osteoclastogenic activity in the hepatic secretome that is increased by FGF21 and largely attributed to insulin-like growth factor binding protein 1 (IGFBP1). Ex vivo osteoclast differentiation and in vivo bone resorption are both enhanced by recombinant IGFBP1 but suppressed by an IGFBP1-blocking antibody. Anti-IGFBP1 treatment attenuates ovariectomy-induced osteoporosis and abolishes FGF21-induced bone loss while maintaining its insulin-sensitizing metabolic benefit...
November 3, 2015: Cell Metabolism
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