keyword
https://read.qxmd.com/read/38492673/interactions-between-skin-resident-dendritic-and-langerhans-cells-and-pain-sensing-neurons
#21
REVIEW
Natalie C Wilcox, Golnar Taheri, Katherine Halievski, Sebastien Talbot, Jaqueline R Silva, Nader Ghasemlou
Various immune cells in the skin contribute to its function as a first line of defence against infection/disease, while its dense innervation by pain-sensing sensory neurons protects the host from injury/damage signals. Dendritic cells (DCs) are a heterogeneous population of cells that link the innate immune response to the adaptive response by capturing, processing, and presenting antigens to promote T-cell differentiation and activation. DCs are abundant across peripheral tissues, including the skin, where they are found in the dermis and epidermis...
March 14, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38492671/estro-siope-guideline-clinical-management-of-radiotherapy-in-atypical-teratoid-rhabdoid-tumors-at-rts
#22
JOURNAL ARTICLE
Beate Timmermann, Claire Alapetite, Karin Dieckmann, Rolf-Dieter Kortmann, Yasmin Lassen-Ramshad, John H Maduro, Monica Ramos Albiac, Umberto Ricardi, Damien C Weber
BACKGROUND AND PURPOSE: Treatment of patients with atypical teratoid/rhabdoid (AT/RT) is challenging, especially when very young (below the age of three years). Radiotherapy (RT) is part of a complex trimodality therapy. The purpose of this guideline is to provide appropriate recommendations for RT in the clinical management of patients not enrolled in clinical trials. MATERIALS AND METHODS: Nine European experts were nominated to form a European Society for Radiotherapy and Oncology (ESTRO) guideline committee...
March 14, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38492634/notoginsenoside-r1-targets-ppar-%C3%AE-to-inhibit-hepatic-stellate-cell-activation-and-ameliorates-liver-fibrosis
#23
JOURNAL ARTICLE
Cheng Guo, Linying Lai, Boyu Ma, Qian Huang, Zhirong Wang
BACKGROUND: Hepatic fibrosis, a common pathological process that occurs in end-stage liver diseases, is a serious public health problem and lacks effective therapy. Notoginsenoside R1 (NR1) is a small molecule derived from the traditional Chinese medicine Sanqi, exhibiting great potential in treating diverse metabolie disorders. Here we aimed to enquired the role of NR1 in liver fibrosis and its underlying mechanism in hepatoprotective effects. METHODS: We investigated the anti-fibrosis effects of NR1 using CCl4 -induced mouse mode of liver fibrosis as well as TGF-β1-activated JS-1, LX-2 cells and primary hepatic stellate cells...
March 14, 2024: Experimental Cell Research
https://read.qxmd.com/read/38492583/clinical-therapeutics-for-proliferative-vitreoretinopathy-in-retinal-detachment
#24
REVIEW
Francesco Sabatino, Philip Banerjee, Mahiul M K Muqit
Proliferative vitreoretinopathy (PVR) is an abnormal and prolonged healing response to retinal injury (retinal detachment, post-retinal detachment surgery) characterised by: pre/subretinal membrane formation; retinal gliosis and retinal shortening, retinal pigment epithelium cell proliferation; and increased glial (mainly Mu¨ller cells), fibroblast and inflammatory cell (macrophage, lymphocyte) activity, leading to tractional retinal holes/breaks and multiple costly eye operations suffered by patients...
March 14, 2024: Survey of Ophthalmology
https://read.qxmd.com/read/38492510/screening-and-characterization-of-potential-anti-gout-components-from-polygonum-cuspidatum-by-integration-off-line-two-dimensional-liquid-chromatography-mass-spectrometry-with-affinity-ultrafiltration-and-on-line-hplc-abts
#25
JOURNAL ARTICLE
Huanying Guo, Simeng Hu, Hongyu Ran, Hongjing Dong, Xiao Wang, Hengqiang Zhao
Polygonum cuspidatum (P. cuspidatum) is a traditional herbal medicine with a long history and proven efficacy in treating gout. However, due to the complexity of composition and extensive content distribution, the substance basis of its anti-gout effectiveness is still unclear. A strategy was proposed via integrating off-line two-dimensional liquid chromatography (2D-LC) and targeted rapid screening technology based on ultrafiltration-liquid chromatography-mass spectrometry (UF-LC/MS) and on-line high-performance liquid chromatography-2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (HPLC-ABTS) to accomplish high coverage and high throughput screening of anti-gout components from P...
March 13, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38492493/discovery-of-novel-biphenyl-sulfonamide-analogues-as-nlrp3-inflammasome-inhibitors
#26
JOURNAL ARTICLE
Chao Huang, Jinyu Liu, Yuxin Chen, Simin Sun, Tongtong Kang, Yuqi Jiang, Xiaoyang Li
The aberrant activation of NLRP3 inflammasome has been observed in various human diseases. Targeting the NLRP3 protein with small molecule inhibitors shows immense potential as an effective strategy for disease intervention. Herein, a series of novel biphenyl-sulfonamide NLRP3 inflammasome inhibitors were designed and synthesized. The representative compound H28 was identified as potent and specific NLRP3 inflammasome inhibitor with IC50 values of 0.57 μM. Preliminary mechanistic studies have revealed that compound H28 exhibits direct binding to the NLRP3 protein (KD : 1...
March 9, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38492342/neuroprotective-potential-of-pyrazole-benzenesulfonamide-derivative-t1-in-targeted-intervention-against-ptz-induced-epilepsy-like-condition-in-in-vivo-zebrafish-model
#27
JOURNAL ARTICLE
Raghul Murugan, S P Ramya Ranjan Nayak, B Haridevamuthu, D Priya, Vellapandian Chitra, Bader O Almutairi, Selvaraj Arokiyaraj, Muthupandian Saravanan, M K Kathiravan, Jesu Arockiaraj
Epilepsy is a chronic neurological disease characterized by a persistent susceptibility to seizures. Pharmaco-resistant epilepsies, impacting around 30 % of patients, highlight the urgent need for improved treatments. Neuroinflammation, prevalent in epileptogenic brain regions, is a key player in epilepsy, prompting the search for new mechanistic therapies. Hence, in this study, we explored the anti-inflammatory potential of pyrazole benzenesulfonamide derivative (T1) against pentylenetetrazole (PTZ) induced epilepsy-like conditions in in-vivo zebrafish model...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492338/butyrate-alleviates-alcoholic-liver-disease-associated-inflammation-through-macrophage-regulation-and-polarization-via-the-hdac1-mir-155-axis
#28
JOURNAL ARTICLE
Lina Zhang, Zhiguo Ma, Xiaoxu Zhang, Jing Wang, Wenyan Tian, Yi Ren, Yajuan Liu, Ting Wang, Yiwei Li, Yuanyuan Liu, Wenke Shen, Ting Li, Jian Liu, Junbai Ma, Xiaoxia Zhang, Shaoqi Yang, Hao Wang
BACKGROUND: We recently found that butyrate could ameliorate inflammation of alcoholic liver disease (ALD) in mice. However, the exact mechanism remains incompletely comprehended. Here, we examined the role of butyrate on ALD-associated inflammation through macrophage (Mψ) regulation and polarization using in vivo and in vitro experiments. METHODS: For in vivo experiments, C57BL/6J mice were fed modified Lieber-DeCarli liquid diets supplemented with or without ethanol and sodium butyrate (NaB)...
March 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492157/modelling-the-effectiveness-of-tepotinib-in-comparison-to-standard-of-care-treatments-in-patients-with-advanced-non-small-cell-lung-cancer-nsclc-harbouring-metex14-skipping-in-the-uk
#29
JOURNAL ARTICLE
Rachael Batteson, Emma Hook, Hollie Wheat, Anthony J Hatswell, Helene Vioix, Thomas McLean, Stamatia Theodora Alexopoulos, Shobhit Baijal, Paul K Paik
BACKGROUND: Patients with non-small cell lung cancer harbouring mesenchymal-epithelial transition exon 14 (METex14) skipping typically demonstrate poorer prognosis than overall non-small cell lung cancer. Until recently, no targeted treatments were available for patients with non-small cell lung cancer harbouring METex14 skipping in the UK, with limited treatments available. OBJECTIVE: This study estimates the long-term survival and quality-adjusted life-year benefit of MET inhibitor tepotinib versus current standard of care from a UK perspective...
March 16, 2024: Targeted Oncology
https://read.qxmd.com/read/38492053/dexamethasone-relieves-the-inflammatory-response-caused-by-inguinal-hernia-meshes-through-mir-155
#30
JOURNAL ARTICLE
Y Li, Y Lv, J Li, P Ling, X Guo, L Zhang, J Ni, Y Long
BACKGROUND: Inguinal hernia is a relatively common condition. Most patients with inguinal hernia require surgery. At present, mesh repair is one of the most effective methods to treat inguinal hernia, but insertion of the mesh can cause inflammation. Dexamethasone (DEX) can treat inflammation, but the mechanism by which DEX alleviates inflammation caused by inguinal hernia mesh placement remains unclear. METHOD: We randomly divided rats into groups: negative control (NC), inguinal hernia (IH), polypropylene mesh (PM), DEX treatment, and miR-155 treatment groups...
March 16, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://read.qxmd.com/read/38491953/analysis-of-clinical-characteristics-and-histopathological-transcription-in-40-patients-afflicted-by-epilepsy-stemming-from-focal-cortical-dysplasia
#31
JOURNAL ARTICLE
Ke Zhang, He Yao, Jixue Yang, Tianming Jia, Qiao Shan, Dongming Li, Mengchun Li, Ling Gan, Xinjun Wang, Yan Dong
OBJECTIVE: This study aims to comprehensively analyze the clinical characteristics and identify the differentially expressed genes associated with drug-resistant epilepsy (DRE) in patients with focal cortical dysplasia (FCD). METHODS: A retrospective investigation was conducted from July 2019 to June 2022, involving 40 pediatric cases of DRE linked to FCD. Subsequent follow-ups were done to assess post-surgical outcomes. Transcriptomic sequencing and quantitative reverse transcription polymerase chain reaction (qRT-PCR) were used to examine differential gene expression between the FCD and control groups...
March 16, 2024: Epilepsia Open
https://read.qxmd.com/read/38491926/efficacy-and-safety-of-covered-stents-versus-bare-metal-stents-for-aortoiliac-occlusive-disease-a-systematic-review-and-meta-analysis
#32
REVIEW
Chenming Hu, Lang Chen, Min Wu, Qianling Ye, Jun Zou, Bin Zhao, Xiang Li, Huaping Wu
PURPOSE: This study aimed to assess the efficacy and safety outcome of covered stents (CSs), as compared with bare-metal stents (BMSs), for the treatment of patients with aortoiliac occlusive disease (AIOD). MATERIALS AND METHODS: A systematic literature search was conducted in PubMed, Embase, and Cochrane Library up to August 2023 to identify all studies comparing efficacy and safety outcomes of CSs versus BMSs for treating AIOD. Our outcome was primary patency, secondary patency, technical success, ankle-brachial index (ABI) variation, target lesion revascularization (TLR), limb salvage, complications, and long-term survival...
March 16, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38491825/the-outcome-in-patients-with-braf-mutated-metastatic-melanoma-treated-with-anti-programmed-death-receptor-1-monotherapy-or-targeted-therapy-in-the-real-world-setting
#33
JOURNAL ARTICLE
Jindřich Kopecký, Marek Pásek, Radek Lakomý, Bohuslav Melichar, Ivona Mrazová, Ondřej Kubeček, Monika Arenbergerová, Radmila Lemstrová, Alžběta Švancarová, Vojtěch Tretera, Alžběta Hlodáková, Kamila Žváčková
BACKGROUND: Immunotherapy and targeted therapy are currently two alternative backbones in the therapy of BRAF-mutated malignant melanoma. However, predictive biomarkers that would help with treatment selection are lacking. METHODS: This retrospective study investigated outcomes of anti-programmed death receptor-1 monotherapy and targeted therapy in the first-line setting in patients with metastatic BRAF-mutated melanoma, focusing on clinical and laboratory parameters associated with treatment outcome...
March 2024: Cancer Medicine
https://read.qxmd.com/read/38491483/under-utilization-of-long-lasting-insecticidal-nets-llins-is-challenging-malaria-elimination-program-in-ethiopia-a-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Fekade Demeke Bayou, Natnael Kebede, Yawkal Tsega, Shambel Nigussie, Temesgen Dessalegn Legassu, Amare Muche, Ayana Alebachew Muluneh, Fanos Yeshanew Ayele
BACKGROUND: Malaria is one of the most common causes of morbidity and mortality in developing countries including Ethiopia. Mass distribution of insecticide-treated nets and indoor residual spray for high malaria risk groups are the major prevention measures in different countries. Achievement of the malaria elimination plan is highly determined by the level of effective utilization of intervention measures. However, there is scarce information showing the national level of insecticide-treated nets utilization...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38491170/targeting-pro-inflammatory-t%C3%A2-cells-as-a-novel-therapeutic-approach-to-potentially-resolve-atherosclerosis-in-humans
#35
JOURNAL ARTICLE
Lin Fan, Junwei Liu, Wei Hu, Zexin Chen, Jie Lan, Tongtong Zhang, Yang Zhang, Xianpeng Wu, Zhiwei Zhong, Danyang Zhang, Jinlong Zhang, Rui Qin, Hui Chen, Yunfeng Zong, Jianmin Zhang, Bing Chen, Jun Jiang, Jifang Cheng, Jingyi Zhou, Zhiwei Gao, Zhenjie Liu, Ying Chai, Junqiang Fan, Pin Wu, Yinxuan Chen, Yuefeng Zhu, Kai Wang, Ying Yuan, Pintong Huang, Ying Zhang, Huiqin Feng, Kaichen Song, Xun Zeng, Wei Zhu, Xinyang Hu, Weiwei Yin, Wei Chen, Jian'an Wang
Atherosclerosis (AS), a leading cause of cardio-cerebrovascular disease worldwide, is driven by the accumulation of lipid contents and chronic inflammation. Traditional strategies primarily focus on lipid reduction to control AS progression, leaving residual inflammatory risks for major adverse cardiovascular events (MACEs). While anti-inflammatory therapies targeting innate immunity have reduced MACEs, many patients continue to face significant risks. Another key component in AS progression is adaptive immunity, but its potential role in preventing AS remains unclear...
March 15, 2024: Cell Research
https://read.qxmd.com/read/38490779/inhaled-nitroglycerin-for-pulmonary-edema-in-air-medical-services-a-retrospective-pilot-study
#36
JOURNAL ARTICLE
Abigail Polzin, Eric D Curtis, Eric Rupe, Hilla I Sang
OBJECTIVE: The use of traditional inhaled pulmonary vasodilators, such as nitric oxide, to treat symptomatic pulmonary edema is not practical in the air medical or prehospital environment because of difficulty with administration. A hospital-based critical care air medical transport service initiated a pilot study to investigate the use of inhaled nitroglycerin (iNTG) as an alternative pulmonary vasodilator. METHODS: For this pilot study, iNTG was administered using a jet nebulizer setup and concentrated nitroglycerin, both of which are widely available in acute care settings...
2024: Air Medical Journal
https://read.qxmd.com/read/38490735/clinical-implementation-of-automated-o-2-titration-in-a-tertiary-care-hospital
#37
JOURNAL ARTICLE
Pierre-Alexandre Bouchard, Geneviève Parent-Racine, Cassiopée Paradis-Gagnon, Mathieu Simon, Yves Lacasse, François Lellouche, François Maltais
Background: When treating acute respiratory failure, both hypoxemia and hyperoxemia should be avoided. SpO2 should be monitored closely and O2 flows adjusted accordingly. Achieving this goal might be easier with automated O2 titration compared to manual titration of fixed-flow O2 We evaluated the feasibility of using an automated O2 titration device in subjects treated for acute hypoxemic respiratory failure in a tertiary care hospital. Methods: Healthcare workers received education and training about oxygen therapy and were familiarized with an automated O2 titration device (FreeO2, Oxynov, Quebec City, Canada)...
March 15, 2024: Respiratory Care
https://read.qxmd.com/read/38490715/efficacy-of-colchicine-in-addition-to-anakinra-in-patients-with-recurrent-pericarditis
#38
JOURNAL ARTICLE
Valentino Collini, Alessandro Andreis, Marzia De Biasio, Maria De Martino, Miriam Isola, Nicole Croatto, Veronica Lepre, Luca Cantarini, Marco Merlo, Gianfranco Sinagra, Antonio Abbate, George Lazaros, Antonio Brucato, Allan L Klein, Massimo Imazio
AIM: Anakinra, an anti IL-1 agent targeting IL-1 alfa and beta, is available for the treatment of recurrent pericarditis in cases with corticosteroid dependence and colchicine resistance after failure of conventional therapies. However, it is unclear if the combination with colchicine, a non-specific inhibitor of the inflammasome targeting the same inflammatory pathway of IL-1, could provide additional benefit to prevent further recurrences. The aim of the present observational study is to assess whether the addition of colchicine on top of anakinra could prolong the time to first recurrence and prevent recurrences better than anakinra alone...
March 15, 2024: Open Heart
https://read.qxmd.com/read/38490697/long-term-efficacy-of-a-2-year-mri-treat-to-target-strategy-on-disease-activity-and-radiographic-progression-in-patients-with-rheumatoid-arthritis-in-clinical-remission-5-year-follow-up-of-the-imagine-ra-randomised-trial
#39
JOURNAL ARTICLE
Signe Møller-Bisgaard, Kim Hørslev-Petersen, Lykke Midtbøll Ørnbjerg, Bo Ejbjerg, Merete Lund Hetland, Jakob Møllenbach Møller, Sabrina Mai Nielsen, Daniel Glinatsi, Mikael Boesen, Kristian Stengaard-Pedersen, Ole Rintek Madsen, Bente Jensen, Jan Alexander Villadsen, Ellen Margrethe Hauge, Oliver Hendricks, Hanne Lindegaard, Niels Steen Krogh, Anne Grethe Jurik, Henrik Thomsen, Robin Christensen, Mikkel Østergaard
OBJECTIVE: To investigate whether a 2-year MRI treat-to-target strategy targeting the absence of osteitis combined with clinical remission, compared with a conventional treat-to-target strategy targeting clinical remission only (IMAGINE-rheumatoid arthritis (RA) trial) improves clinical and radiographic outcomes over 5 years in patients with RA in clinical remission. METHODS: IMAGINE-more was an observational extension study of the original 2-year IMAGINE-RA randomised trial (NCT01656278)...
March 15, 2024: RMD Open
https://read.qxmd.com/read/38490687/neurophysiological-outcomes-that-sustained-clinically-significant-improvements-over-3-years-of-physiologic-ecap-controlled-closed-loop-spinal-cord-stimulation-for-the-treatment-of-chronic-pain
#40
JOURNAL ARTICLE
Nagy A Mekhail, Robert M Levy, Timothy R Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Corey W Hunter, Steven M Rosen, Shrif J Costandi, Steven M Falowski, Abram H Burgher, Jason E Pope, Christopher A Gilmore, Farooq A Qureshi, Peter S Staats, James Scowcroft, Tory McJunkin, Christopher K Kim, Michael I Yang, Thomas Stauss, Richard Rauck, Rui V Duarte, Nicole Soliday, Angela Leitner, Erin Hanson, Zhonghua Ouyang, Dave Mugan, Lawrence Poree
INTRODUCTION: A novel, spinal cord stimulation (SCS) system with a physiologic closed-loop (CL) feedback mechanism controlled by evoked compound action potentials (ECAPs) enables the optimization of physiologic neural dose and the accuracy of the stimulation, not possible with any other commercially available SCS systems. The report of objective spinal cord measurements is essential to increase the transparency and reproducibility of SCS therapy. Here, we report a cohort of the EVOKE double-blind randomized controlled trial treated with CL-SCS for 36 months to evaluate the ECAP dose and accuracy that sustained the durability of clinical improvements...
March 15, 2024: Regional Anesthesia and Pain Medicine
keyword
keyword
119042
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.