keyword
https://read.qxmd.com/read/38493481/loss-of-dnmt3a-increased-self-renewal-and-resistance-to-pegifn%C3%AE-in-jak2-v617f-positive-myeloproliferative-neoplasms
#1
JOURNAL ARTICLE
Marc Usart, Jan Stetka, Damien Luque Paz, Nils Hansen, Quentin Kimmerlin, Tiago Almeida Fonseca, Melissa Lock, Lucia Kubovcakova, Riikka Karjalainen, Hui Hao-Shen, Anastasiya Börsch, Athimed El Taher, Jessica Schulz, Jean-Christophe Leroux, Stefan Dirnhofer, Radek C Skoda
Pegylated interferon alpha (pegIFNα) can induce molecular remissions in JAK2-V617F-positive myeloproliferative neoplasms (MPN) patients by targeting long-term hematopoietic stem cells (LT-HSCs). Additional somatic mutations in genes regulating LT-HSC self-renewal, such as DNMT3A, have been reported to have poorer responses to pegIFNα. We investigated if DNMT3A loss leads to alterations in JAK2-V617F LT-HSCs functions conferring resistance to pegIFNα treatment in a mouse model of MPN and in hematopoietic progenitors from MPN patients...
March 17, 2024: Blood
https://read.qxmd.com/read/38493439/predicting-efficacy-assessment-of-combined-treatment-of-radiotherapy-and-nivolumab-for-nsclc-patients-through-virtual-clinical-trials-using-qsp-modeling
#2
JOURNAL ARTICLE
Miriam Schirru, Hamza Charef, Khalil-Elmehdi Ismaili, Frédérique Fenneteau, Didier Zugaj, Pierre-Olivier Tremblay, Fahima Nekka
Non-Small Cell Lung Cancer (NSCLC) remains one of the main causes of cancer death worldwide. In the urge of finding an effective approach to treat cancer, enormous therapeutic targets and treatment combinations are explored in clinical studies, which are not only costly, suffer from a shortage of participants, but also unable to explore all prospective therapeutic solutions. Within the evolving therapeutic landscape, the combined use of radiotherapy (RT) and checkpoint inhibitors (ICIs) emerged as a promising avenue...
March 17, 2024: Journal of Pharmacokinetics and Pharmacodynamics
https://read.qxmd.com/read/38493427/circrna-hlcs-regulates-lens-epithelial-cell-apoptosis-via-mir-338-3p-bpnt1-axis
#3
JOURNAL ARTICLE
Lianyi Sun, Fengzhi Li, Shuwei Bai, Chunchao Bi
PURPOSE: The purpose of this study was to investigate the effect of circ_HLCS on age-related cataract (ARC). METHODS: Circ_HLCS, microRNA (miR)-338-3p, and bisphosphate 3'-nucleotidase 1 (BPNT1) were quantified by quantitative real-time polymerase chain reaction or western blot. Cell proliferation and cell viability were assessed by the 5-Ethynyl-2'-deoxyuridinr and cell counting kit-8 assays. Cell apoptosis was detected by flow cytometry. Targeted correlations among circ_HLCS, miR-338-3p, and BPNT1 were verified by the dual-luciferase reporter and RNA pull-down assays...
March 17, 2024: International Ophthalmology
https://read.qxmd.com/read/38493349/safety-and-effectiveness-of-the-phoenix-atherectomy-device-for-endovascular-treatment-of-common-femoral-and-popliteal-arteries-results-of-the-en-mobile-trial
#4
JOURNAL ARTICLE
Christoph Schöfthaler, Nicola Troisi, Giovanni Torsello, Amila Jehn, Michael Lichtenberg, Jan C Karcher, Konstantinos Stavroulakis, Mario D'Oria, Athanasios Saratzis, Hany Zayed, Martin Andrassy, Grigorios Korosoglou
Background: This study aimed to assess the peri- and postprocedural outcomes of atherectomy-assisted endovascular treatment of the common femoral (CFA) and popliteal arteries. Methods: Phoenix atherectomy was used for the treatment of 73 and 53 de novo CFA and popliteal artery lesions, respectively, in 122 consecutive patients. Safety endpoints encompassed perforation and peripheral embolization. Postprocedural endpoints included freedom from clinically driven target lesion revascularization (CD-TLR) and clinical success (an improvement of ⩾ 2 Rutherford category [RC])...
March 17, 2024: Vascular Medicine
https://read.qxmd.com/read/38493298/partial-trailside-japanese-barberry-ranunculales-berberidaceae-removal-did-not-reduce-the-abundance-of-questing-blacklegged-ticks-acari-ixodidae
#5
JOURNAL ARTICLE
Susan P Elias, Peter W Rand, Charles B Lubelczyk, Melanie R McVety, Robert P Smith
In a nature reserve in southern Maine, we removed invasive Japanese barberry (Berberis thunbergii de Candolle) along sections of forested recreational trails that ran through dense barberry infestations. Barberry thickets provide questing substrate and a protective microclimate for blacklegged ticks (Ixodes scapularis Say), and trail users could brush up against encroaching barberry and acquire ticks. Trailside barberry removal will reduce or eliminate encroaching tick questing substrate and could reduce trailside questing tick abundance by creating a microclimate more hostile to ticks...
March 16, 2024: Environmental Entomology
https://read.qxmd.com/read/38493273/effect-of-suboptimal-disease-control-on-patient-quality-of-life-real-world-data-from-the-observational-ibd-podcast-canada-trial
#6
JOURNAL ARTICLE
Jesse Siffledeen, Sunny Singh, Scott M Shulman, John Igoe, Tobias Heatta-Speicher, Claudia Leitner, Chia Hui Chung, Laura Targownik
BACKGROUND: The real-world application of STRIDE-II treatment targets to identify whether disease control is optimal in Crohn's disease (CD) and ulcerative colitis (UC) is not well known. AIMS: This study aimed to estimate proportions of patients with suboptimally controlled CD and UC in real-world Canadian healthcare settings and the impact on quality of life (QoL). METHODS: The noninterventional, multicenter, observational IBD-PODCAST Canada study comprised a single study visit involving routine assessments, patient- and clinician-completed questionnaires, and a retrospective chart review...
March 16, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38493137/investigation-of-the-impact-of-bromodomain-inhibition-on-cytoskeleton-stability-and-contraction
#7
JOURNAL ARTICLE
Alexander Bigger-Allen, Ali Hashemi Gheinani, Rosalyn M Adam
BACKGROUND: Injury to contractile organs such as the heart, vasculature, urinary bladder and gut can stimulate a pathological response that results in loss of normal contractility. PDGF and TGFβ are among the most well studied initiators of the injury response and have been shown to induce aberrant contraction in mechanically active cells of hollow organs including smooth muscle cells (SMC) and fibroblasts. However, the mechanisms driving contractile alterations downstream of PDGF and TGFβ in SMC and fibroblasts are incompletely understood, limiting therapeutic interventions...
March 16, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38492983/inhibition-of-keloid-fibroblast-proliferation-by-artesunate-is-mediated-by-targeting-the-ire1%C3%AE-xbp1-signaling-pathway-and-decreasing-tgf-%C3%AE-1
#8
JOURNAL ARTICLE
Xiaomei Han, Shaoqian Jiang, Caixia Hu, Ying Wang, Lu Zhao, Wenqing Wang
BACKGROUND: Keloid is a benign hyperplastic dermatosis with high recurrence rate and complex pathogenesis. There is no universally effective treatment yet. New therapies and elucidation of pathogenesis are urgently required. AIMS: To explore the function of IRE1α/XBP1 in keloid fibroblasts and to investigate the potential mechanism of artesunate in inhibiting keloid hyperplasia. METHODS: Human keloid fibroblasts (KFs) were cultured, and the expressions of XBP1 and TGF-β1 were detected by immunohistochemistry...
March 5, 2024: Burns
https://read.qxmd.com/read/38492976/clinical-outcomes-with-biodegradable-versus-durable-polymer-drug-eluting-stents-in-patients-with-st-elevation-myocardial-infarction
#9
JOURNAL ARTICLE
Gustavo Neves de Araujo, Guilherme Pinheiro Machado, Marcia Moura, Anderson Donelli Silveira, Luiz Carlos Bergoli, Felipe Costa Fuchs, Rodrigo Vugman Wainstein, Sandro Cadaval Goncalves, Pedro A Lemos, Alexandre Schaan de Quadros, Marco Vugman Wainstein
BACKGROUND: Coronary drug-eluting stents (DES) built with either durable (DP) or biodegradable (BP) polymeric coatings have been largely tested and are extensively available for routine use. However, their comparative performance remains an open question, particularly in more complex subsets of patients. AIMS: We evaluated the outcomes of patients with ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI) using DP-DES versus BP-DES in a large multicenter real-world registry...
March 8, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38492913/motivations-for-and-against-participation-in-neonatal-research-insights-from-interviews-of-diverse-parents-approached-for-neonatal-research-in-the-us
#10
JOURNAL ARTICLE
Elliott Mark Weiss, Pamela K Donohue, Susan H Wootton, Emily Stevens, Stephanie L Merhar, Mihai Puia-Dumitrescu, Amanda Mercer, Ellie Oslin, Kathryn M Porter, Benjamin S Wilfond
OBJECTIVE: To describe parents' motivations for and against participation in neonatal research, including the views of those who declined participation. STUDY DESIGN: We performed 44 semi-structured, qualitative interviews of parents approached for neonatal research. Here we describe their motivations for and against participation. RESULTS: Altruism was an important reason parents chose to participate. Some hoped participation in research would benefit their infant...
March 14, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38492894/targeting-ese3-ehf-with-nifurtimox-inhibits-cxcr2-neutrophil-infiltration-and-overcomes-pancreatic-cancer-resistance-to-chemotherapy-and-immunotherapy
#11
JOURNAL ARTICLE
Yongjie Xie, Tianxing Zhou, Xueyang Li, Kaili Zhao, Weiwei Bai, Xupeng Hou, Ziyun Liu, Bo Ni, Zhaoyu Zhang, Jingrui Yan, Yifei Wang, Wenna Jiang, Hongwei Wang, Antao Chang, Song Gao, Tiansuo Zhao, Shengyu Yang, Chongbiao Huang, Jing Liu, Jihui Hao
BACKGROUND & AIMS: Since pancreatic cancer responds poorly to chemotherapy and immunotherapy, it is necessary to identify novel targets and compounds to overcome resistance to treatment. METHODS: This study analyzed genomic SNP sequencing, single-cell RNA sequencing, and spatial transcriptomics. Ehf-knockout mice, KPC (LSL-KrasG12D/+ , LSL-Trp53R172H/+ and Pdx1-Cre) mice, CD45.1+BALB/C nude mice, and CD34+humanized mice were also used as subjects. Multiplexed immunohistochemistry and flow cytometry were performed to investigate the proportion of tumor-infiltrated CXCR2+neutrophils...
March 14, 2024: Gastroenterology
https://read.qxmd.com/read/38492877/inhibition-of-both-nox-and-tnf-%C3%AE-exerts-substantial-renoprotective-effects-in-renal-ischemia-reperfusion-injury-rat-model
#12
JOURNAL ARTICLE
Amina A Bayoumi, Enssaf Ahmad Ahmad, Islam A A E-H Ibrahim, Mona F Mahmoud, Mahmoud H Elbatreek
BACKGROUND AND AIMS: Acute kidney injury (AKI) due to renal ischemia-reperfusion injury (RIRI) is associated with high morbidity and mortality, with no renoprotective drug available. Previous research focused on single drug targets, yet this approach has not reached translational success. Given the complexity of this condition, we aimed to identify a disease module and apply a multitarget network pharmacology approach. METHODS: Identification of a disease module with potential drug targets was performed utilizing Disease Module Detection algorithm using NADPH oxidases (NOXs) as seeds...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38492846/monitoring-the-interaction-between-solid-lipid-nanoparticles-and-alveolar-macrophages-via-the-label-free-technique
#13
JOURNAL ARTICLE
Pijush Kumar Paul, Wei Wu, Teerapol Srichana
Macrophages are employed as targets for delivering genes, drugs, or lipid nanoparticles into tumors or other specific sites. Studying the interaction between solid lipid nanoparticles (SLNs) and macrophages is essential for assessing nanotoxicity and advancing the development of nanomedicines. However, limited data are currently available on the membrane microstructure and biochemical changes that occur when macrophages interact with SLNs. We conducted a label-free morphological and biochemical investigation of NR8383 macrophages using optical diffraction tomography (ODT), which validated the efficiency of the SLNs as a drug delivery system...
March 14, 2024: Journal of Pharmaceutical Sciences
https://read.qxmd.com/read/38492825/acanthopanax-senticosus-cultures-fermented-by-lactobacillus-rhamnosus-enhanced-immune-response-through-improvement-of-antioxidant-activity-and-inflammation-in-crucian-carp-carassius-auratus
#14
JOURNAL ARTICLE
Yi-Han Ma, Yu-Di Sheng, Di Zhang, Jun-Tong Liu, Ye Tian, Hui Li, Xiao-Fei Li, Na Li, Peng Sun, Shahrood Ahmed Siddiqui, Wu-Wen Sun, Lei Zhang, Xiao-Feng Shan, Chun-Feng Wang, Ai-Dong Qian, Dong-Xing Zhang
Lactic acid bacteria (LAB) have been recognized as safe microorganism that improve micro-flora disturbances and enhance immune response. A well-know traditional herbal medicine, Acanthopanax senticosus (As) was extensively utilized in aquaculture to improve growth performance and disease resistance. Particularly, the septicemia, skin wound and gastroenteritis caused by Aeromonas hydrophila threaten the health of aquatic animals and human. However, the effects of probiotic fermented with A. senticosus product on the immune regulation and pathogen prevention in fish remain unclear...
March 14, 2024: Microbial Pathogenesis
https://read.qxmd.com/read/38492812/radiation-therapy-quality-assurance-analysis-of-alliance-a021501-preoperative-mfolfirinox-or-mfolfirinox-plus-hypofractionated-radiation-therapy-for-borderline-resectable-adenocarcinoma-of-the-pancreas
#15
JOURNAL ARTICLE
Leila T Tchelebi, Diana Segovia, Koren Smith, Qian Shi, T J Fitzgerald, Michael D Chuong, Tyler J Zemla, Eileen M O'Reilly, Jeffrey Meyerhardt, Eugene J Koay, Jessica Leif, Ardaman Shergill, Matthew Hg Katz, Joseph M Herman
BACKGROUND: Alliance A021501 is the first randomized trial to evaluate stereotactic body radiation therapy (SBRT) for borderline resectable pancreatic ductal adenocarcinoma (PDAC) after neoadjuvant chemotherapy. In this post hoc study, we reviewed the quality of radiation therapy (RT) delivered. METHODS: SBRT (6.6 Gy x 5) was intended, although hypofractionated RT (5 Gy x 5) (HIGRT) was permitted if SBRT specifications could not be met. Institutional credentialing through the National Cancer Institute-funded Imaging and Radiation Oncology Core (IROC) was required...
March 14, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38492794/mechanism-interpretation-of-guhan-yangshengjing-for-protection-against-alzheimer-s-disease-by-network-pharmacology-and-molecular-docking
#16
JOURNAL ARTICLE
Suet Cheung, Yuan Zhong, Lei Wu, Xiaomeng Jia, Meng-Qi He, Yongjian Ai, Qisen Jiao, Qionglin Liang
ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangshengjing (GHYSJ) is an effective prescription for delaying progression of Alzheimer's disease (AD) based on the ancient Chinese medical classics excavated from Mawangdui Han Tomb. Comprising a combination of eleven traditional Chinese herbs, the precise protective mechanism through which GHYSJ acts on AD progression remains unclear and has significant implications for the development of new drugs to treat AD. AIM OF THE STUDY: To investigate the mechanism of GHYSJ in the treatment of AD through network pharmacology and validate the results through in vitro experiments...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492793/a-study-on-the-anti-senescent-effects-of-flavones-derived-from-prinsepia-utilis-royle-seed-residue
#17
JOURNAL ARTICLE
Junxi Liu, Liping Qu, Feifei Wang, Zaoju Mei, Xinlang Wu, Bo Wang, Haiyang Liu, Li He
ETHNOPHARMACOLOGICAL RELEVANCE: Prinsepia utilis Royle, also known as the Anas fruit, is a unique perennial woody oil plant from Yunnan Province, China. In the ancient texts of Dongba sutras and Yunnan Southern Materia Medica, it has been documented that the local Naxi, Tibetan, and Mosuo communities extensively utilize the root and leaf fruits of green thorns for various purposes. These include treating mild-to-moderate specific dermatitis, moisturising the skin, providing protection against UV damage, aiding childbirth in pregnant women, safeguarding stomach health, reducing the risk of arteriosclerosis, and delaying aging...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492791/deciphering-the-antidepressant-effects-of-rosa-damascena-essential-oil-mediated-through-the-serotonergic-synapse-signaling-pathway
#18
JOURNAL ARTICLE
Ning Xia, Jie Wang, Qiuting Guo, Jiawei Duan, Xuan Wang, Peijie Zhou, Jinkai Li, Tiantian Tang, Taotao Li, Huiting Li, Zhenfeng Wu, Ming Yang, Jing Sun, Dongyan Guo, Xing Chang, Xiaofei Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Rosa damascena is an ancient plant with significance in both medicine and perfumery that have a variety of therapeutic properties, including antidepressant, anti-anxiety, and anti-stress effects. Rose damascena essential oil (REO) has been used to treat depression, anxiety and other neurological related disorders in Iranian traditional medicine. However, its precise mechanism of action remains elusive. AIM OF THE STUDY: The aim of this study was to investigate the impact and mechanism underlying the influence of REO on chronic unpredictable mild stress (CUMS) rats...
March 14, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38492675/empagliflozin-and-pirfenidone-confer-renoprotection-through-suppression-of-glycogen-synthase-kinase-3%C3%AE-and-promotion-of-tubular-regeneration-in-rats-with-induced-metabolic-syndrome
#19
JOURNAL ARTICLE
Hoda E Mohamed, Merna A Abdelhady, Asmaa M Elmaghraby, Rania A Elrashidy
Metabolic syndrome (MetS) is largely coupled with chronic kidney disease (CKD). Glycogen synthase kinase-3β (GSK-3β) pathway drives tubular injury in animal models of acute kidney injury; but its contribution in CKD is still elusive. This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3β signaling pathway. Adult male rats received 10%w/v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose...
March 14, 2024: Toxicology and Applied Pharmacology
https://read.qxmd.com/read/38492674/crosstalk-between-autophagy-and-inflammasomes-in-ricin-induced-inflammatory-injury
#20
JOURNAL ARTICLE
Shiji Zhang, Na Zhao, Suli Song, Yanchun Wang, Yan Wang, Chengbiao Sun, Mingxin Dong, Mengqi Huo, Na Xu, Wensen Liu, Guorui Li
Ricin (ricin toxin, RT) has the potential to cause damage to multiple organs and systems. Currently, there are no existing antidotes, vaccinations, or effective therapies to prevent or treat RT intoxication. Apart from halting protein synthesis, RT also induces oxidative stress, inflammation and autophagy. To explore the mechanisms of RT-induced inflammatory injury and specific targets of prevention and treatment for RT poisoning, we characterized the role of cross-talk between autophagy and NLRP3 inflammasome in RT-induced damage and elucidated the underlying mechanisms...
March 14, 2024: Toxicology and Applied Pharmacology
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