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https://www.readbyqxmd.com/read/29764444/molecular-and-clinical-characterization-of-ptpn2-expression-from-rna-seq-data-of-996-brain-gliomas
#1
Peng-Fei Wang, Hong-Qing Cai, Chuan-Bao Zhang, Yan-Michael Li, Xiang Liu, Jing-Hai Wan, Tao Jiang, Shou-Wei Li, Chang-Xiang Yan
BACKGROUND: Immune checkpoint inhibitors have been shown to promote antitumor immunity and achieve durable tumor remissions. However, certain tumors are refractory to current immunotherapy. These negative results encouraged us to uncover other therapeutic targets and strategies. PTPN2 (protein tyrosine phosphatase, non-receptor type 2) has been newly identified as an immunotherapy target. Loss of PTPN2 sensitizes the tumor to immunotherapy via IFNγ signaling. METHODS: Here, we investigated the relationship between PTPN2 mRNA levels and clinical characteristics in gliomas...
May 15, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29749526/human-hla%C3%A2-f-adjacent-transcript-10-promotes-the-formation-of-cancer-initiating-cells-and-cisplatin-resistance-in-bladder-cancer
#2
Chen Li, Zhenfan Wang, Ninghan Feng, Jian Dong, Xiaoyan Deng, Yin Yue, Yuehong Guo, Jianquan Hou
Epithelial to mesenchymal transition (EMT) serves important roles in tumor invasion, metastasis, formation of cancer initiating cells (CICs) and drug resistance. HLA‑F adjacent transcript 10 (FAT10) has been proposed as an oncogene in bladder cancer. However, the functional contribution of FAT10 to EMT and the formation of CICs remains unclear in bladder cancer. The present study reports that FAT10 protein expression is upregulated in bladder cancer cell lines, and the overexpression of FAT10 promotes EMT and the formation of CICs in bladder cancer UMUC‑3 cells...
May 9, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749455/anti%C3%A2-metastatic-effects-of-aidi-on-human-esophageal-squamous-cell-carcinoma-by-inhibiting-epithelial%C3%A2-mesenchymal-transition-and-angiogenesis
#3
Qingtong Shi, Yali Diao, Feng Jin, Zhiyan Ding
Aidi injection, a proprietary Chinese medicine, has been widely used for the treatment of cancer. However, its effects and potential mechanism in esophageal squamous cell carcinoma (ESCC) have not yet been characterized. The aim of the present study was to identify the mechanism underlying the anti‑metastatic effects of treatment with Aidi. To test the effects and mechanism, EC9706 and KYSE70 cells were selected for in vitro experiments. In vivo, the anti‑metastatic effects of Aidi injection on a nude mouse peritoneal metastasis model were examined, and the mechanisms were assessed with immunohistochemical staining...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29732152/molecular-mechanisms-underlying-the-antimetastatic-activity-of-bufalin
#4
REVIEW
Jie Wang, Yue Xia, Qingshong Zuo, Teng Chen
Bufalin is a monomer compound extract from Chansu, which is a traditional Chinese medicine obtained from the skin and parotid venom glands of toads, such as Bufo bufo gargarizans Cantor and Bufo melanostictus Schneider. Chansu had been used in traditional Chinese medicine for >1,000 years due to its cardiac, anti-inflammatory and anticancer properties. Previous studies identified bufalin as the main anticancer compound of Chansu, and recent evidence has corroborated its anticancer properties. Bufalin inhibits cancer cell proliferation, induces cell cycle arrest, induces cancer cell apoptosis, inhibits neovascularization, induces cell differentiation, inhibits cancer metastasis and invasion, and enhances chemotherapeutic drug sensitivity...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29731224/farrerol-overcomes-the-invasiveness-of-lung-squamous-cell-carcinoma-cells-by-regulating-the-expression-of-inducers-of-epithelial-mesenchymal-transition
#5
Bin Li, Peng Chen, Jie-Hua Wang, Li Li, Jin-Lan Gong, Hui Yao
In recent years Epithelial Mesenchymal Transition (EMT) has been proposed as a mechanism indispensable to acquisition of metastatic properties by tumor cells. In this study we tested the ability of Farrerol, a Chinese herb-derived compound to ablate the EMT in human lung squamous cell carcinoma cells. Human lung squamous cell carcinoma cells, Calu-1 were treated with various concentrations of Farrerol for 24 h to examine its effect on their viability by the MTT assay. Only those concentrations which showed least effect on the viability of Calu-1 cells were further used to evaluate the expression of epithelial and mesenchymal markers by western blotting...
May 4, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29703011/desmoplastic-small-round-cell-tumor-of-the-middle-ear-a-case-report
#6
Jing Xu, Mengwei Yao, Xinxin Yang, Tao Liu, Shaohua Wang, Dengdian Ma, Xiaoyu Li
RATIONALE: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive and malignant tumor. This report describes a case involving DSRCT of the middle ear which no case has been reported in the literature till date. PATIENT CONCERN: A 59-year-old Chinese man with a 40-year history of repeated suppuration of his right ear and 1-year history of drooping of the angle of mouth. The CT of the middle ear and brain scan and enhanced MRI showed space occupying lesion in the right middle ear...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29693145/icariin-promotes-stable-chondrogenic-differentiation-of-bone-marrow-mesenchymal-stem-cells-in-self%C3%A2-assembling-peptide-nanofiber-hydrogel-scaffolds
#7
Zhicong Wang, Kaihua Li, Huijun Sun, Ji Wang, Zhuodong Fu, Mozhen Liu
Icariin, a traditional Chinese medicine, has previously been demonstrated to promote chondrogenesis of bone marrow mesenchymal stem cells (BMSCs) in traditional 2D cell culture. The present study investigated whether icariin has the potential to promote stable chondrogenic differentiation of BMSCs without hypertrophy in a 3D microenvironment. BMSCs were cultivated in a self‑assembling peptide nanofiber hydrogel scaffold in chondrogenic medium for 3 weeks. Icariin was added to the medium throughout the culture period at concentrations of 1x10‑6 M...
April 23, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29684087/ovostatin-2-knockdown-significantly-inhibits-the-growth-migration-and-tumorigenicity-of-cutaneous-malignant-melanoma-cells
#8
Ying-Xue Huang, Hao Song, Yue Tao, Xue-Bao Shao, Xue-Si Zeng, Xiu-Lian Xu, Jin-Liang Qi, Jian-Fang Sun
BACKGROUND: We previously identified ovostatin 2 (OVOS2) as a new candidate gene for cutaneous malignant melanoma (CMM) in a Chinese population. In this study, we aimed to investigate the exact role of OVOS2 in cell proliferation, invasion, and tumorigenesis of melanoma A375 cells. METHODS: The downregulation of OVOS2 expression was performed using lentiviral vectors with specific shRNA. The effects of OVOS2 expression on cell proliferation, cell cycle, cell migration, cell invasion, and potential of tumorigenesis were further investigated...
2018: PloS One
https://www.readbyqxmd.com/read/29679717/stat-3-regulation-of-cxcr4-is-necessary-for-the-prenylflavonoid-icaritin-to-enhance-mesenchymal-stem-cell-proliferation-migration-and-osteogenic-differentiation
#9
R Z L Lim, L Li, E L Yong, N Chew
Mesenchymal stem cell (MSC) dysfunction has been implicated in the pathogenesis of osteoporosis. MSCs derived from osteoporotic subjects demonstrate significant impairment in proliferation, adhesion and chemotaxis, and osteogenic differentiation, leading to reduced functional bone-forming osteoblasts and ultimately nett bone loss and osteoporosis. Epimedium herbs and its active compound Icaritin (ICT) have been used in Chinese ethnopharmacology for the treatment of metabolic bone diseases. Using an in-vitro cell culture model, we investigated the benefits of ICT treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provide novel data to describe its mechanism of action...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29614624/baicalein-suppresses-non-small-cell-lung-cancer-cell-proliferation-invasion-and-notch-signaling-pathway
#10
Guangfeng Su, Hao Chen, Xinhua Sun
BACKGROUND: Baicalein is an important Chinese herbal medicine and has multiple pharmacological activities. However, the biological mechanisms of the anti-tumor effects of Baicalein on non small cell lung cancer (NSCLC) still need to be understood. METHODS: Human NSCLC A549 and H1299 cells were pretreated with Baicalein or DMSO. Cells viability and transwell cell invasion assays were performed to assess cell proliferation and invasion. QRT-PCR assay was used to analyze mRNA expression levels of Twist1, E-cadhertin, Vimentin, Notch1 and hes-1...
March 23, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29577647/long-noncoding-rna-linc00152-is-a-potential-prognostic-biomarker-in-patients-with-high-grade-glioma
#11
Wen Wang, Fan Wu, Zheng Zhao, Kuan-Yu Wang, Ruo-Yu Huang, Hao-Yuan Wang, Qing Lan, Jiang-Fei Wang, Ji-Zong Zhao
AIMS: To investigate the role of LINC00152 in high-grade glioma (HGG). METHODS: We collected data from the Chinese Glioma Genome Atlas (CGGA) microarray, CGGA RNA sequencing, and GSE16011 datasets to evaluate the expression and prognostic relationship of LINC00152 in patients with HGGs. A knockdown assay was performed to determine the function of LINC00152 in glioma development and progression in vitro and in vivo. RESULTS: The expression of LINC00152 was increased with glioma grade, especially in the mesenchymal TCGA subtype...
March 25, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29554896/extract-of-stellerachamaejasme-l-esc-inhibits-growth-and-metastasis-of-human-hepatocellular-carcinoma-via-regulating-microrna-expression
#12
Xiaoni Liu, Shuang Wang, Jianji Xu, Buxin Kou, Dexi Chen, Yajie Wang, Xiaoxin Zhu
BACKGROUND: MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract of Stellerachamaejasme L, had been confirmed as a potential anti-tumor extract of Traditional Chinese Medicine. In light of the important role of miRNAs in hepatocellular carcinoma, we questioned whether the inhibitory effects of ESC on hepatocellular carcinoma (HCC) were associated with miRNAs. METHODS: The proliferation inhibition of ESC on HCC cells was measured with MTT assay...
March 20, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29549584/acetylshikonin-from-zicao-ameliorates-renal-dysfunction-and-fibrosis-in-diabetic-mice-by-inhibiting-tgf-%C3%AE-1-smad-pathway
#13
Zezhao Li, Zhen Hong, Zhiqing Peng, Yongcai Zhao, Rusheng Shao
Diabetic nephropathy (DN) is the major cause of end-stage renal disease in diabetic patients. Zicao, a well-known Chinese traditional medicine, has attracted much attention due to its beneficial effects in various medical fields. In this study, we attempted to investigate the effects and mechanisms of action of acetylshikonin, the main ingredient of Zicao, on renal dysfunction in DN. Our results showed that administration with acetylshikonin not only decreased blood urea nitrogen, urine creatinine and the mean kidney-to-body weight ratio in streptozotocin-induced diabetic mice, but also restored the loss of body weight, whereas the blood glucose was not changed...
March 17, 2018: Human Cell
https://www.readbyqxmd.com/read/29542684/exosomes-from-suxiao-jiuxin-pill-treated-cardiac-mesenchymal-stem-cells-decrease-h3k27-demethylase-utx-expression-in-mouse-cardiomyocytes-in-vitro
#14
Xiao-Fen Ruan, Yong-Jun Li, Cheng-Wei Ju, Yan Shen, Wei Lei, Can Chen, Yang Li, Hong Yu, Yu-Tao Liu, Il-Man Kim, Xiao-Long Wang, Neal L Weintraub, Yao-Liang Tang
Suxiao Jiuxin Pill (SJP) is a traditional Chinese medicine for the treatment of acute coronary syndrome in China, which contains two principal components, tetramethylpyrazine (TMP) and borneol (BOR). Thus far, however, the molecular mechanisms underlying the beneficial effects of SJP on the cardiac microenvironment are unknown. Cardiac mesenchymal stem cells (C-MSCs) communicate with cardiomyocytes (CMs) through the release of microvesicles (exosomes) to restore cardiac homeostasis and elicit repair, in part through epigenetic regulatory mechanisms...
March 15, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29542682/suxiao-jiuxin-pill-promotes-exosome-secretion-from-mouse-cardiac-mesenchymal-stem-cells-in-vitro
#15
Xiao-Fen Ruan, Cheng-Wei Ju, Yan Shen, Yu-Tao Liu, Il-Man Kim, Hong Yu, Neal Weintraub, Xiao-Long Wang, Yao-Liang Tang
Cardiac mesenchymal stem cells (C-MSCs) are endogenous cardiac stromal cells that play a role in heart repair after injury. C-MSC-derived exosomes (Exo) have shown protective effects against apoptosis induced by acute myocardial ischemia/reperfusion. Suxiao Jiuxin pill (SJP) is a traditional Chinese medicine (TCM) formula used in China for the treatment of acute myocardial ischemia, which contains tetramethylpyrazine (TMP) and borneol (BOR) as major components. In this study, we investigated whether SJP treatment affected exosome release from C-MSCs in vitro...
March 15, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29541209/relb-a-good-prognosis-predictor-links-cell-cycle-and-migration-to-glioma-tumorigenesis
#16
Feng Shen, Qing Guo, Qi Hu, Ailiang Zeng, Weining Wu, Wei Yan, Yongping You
Nuclear factor κB (NF-κB) exhibits an important role in inflammation and tumorigenesis. The key regulatory protein of the pathway, RELB Proto-Oncogene, NF-KB Subunit (relB), is overexpressed and associated with the pathogenesis of a variety of malignant tumors. However, the molecular features and clinical signature of relB expression in gliomas remains to be elucidated. The present study obtained the raw sequencing data of 325 glioma samples of all grades from the Chinese Glioma Genome Atlas (CGGA) database and human glioma cell line (LN229) from the Chinese Academy of Sciences cell bank...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29537081/exome-sequencing-reveals-the-genetic-landscape-and-frequent-inactivation-of-pcdhb3-in-chinese-rectal-cancers
#17
Wen Ye, Shaoping Ling, Ran-Yi Liu, Zhi-Zhong Pan, Gaoyuan Wang, Shijuan Gao, Jiangxue Wu, Lihua Cao, Lili Dong, Yingchang Li, Yi Zhou, Wuying Du, Xiangqi Meng, Jinna Chen, Xinyuan Guan, Yulong He, Changchuan Pan, Xf Steven Zheng, Xuemei Lu, Shuai Chen, Wenlin Huang
Colorectal cancer (CRC) is the third most common cancer worldwide, with more than 1.3 million new cases and 690 000 deaths each year. In China, the incidence of CRC has increased dramatically due to dietary and lifestyle changes, to become the fifth leading cause of cancer-related death. Here, we performed whole-exome sequencing in 50 rectal cancer cases among the Chinese population as part of the International Cancer Genome Consortium research project. Frequently mutated genes and enriched pathways were identified...
June 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29523182/cerebrospinal-fluid-stem-cell-interactions-may-pave-the-path-for-cell-based-therapy-in-neurological-diseases
#18
REVIEW
Chao Ren, Peiyuan Yin, Neng Ren, Zhe Wang, Jiahui Wang, Caiyi Zhang, Wei Ge, Deqin Geng, Xiaotong Wang
Recent studies have suggested that the regulation of endogenous neural stem cells (NSCs) or transplanting of exogenous nerve cells are the newest and most promising methods for the treatment of dementia and other neurological diseases. The special location and limited number of endogenous NSCs, however, restrict their clinical application. The success in directional differentiation of exogenous stem cells from other tissue sources into neural cells has provided a novel source for NSCs. Study on the relative mechanisms is still at the preliminary stage...
March 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29511614/the-combined-effect-of-pdx1-overexpression-and-shh-manipulation-on-the-function-of-insulin-producing-cells-derived-from-adipose-tissue-stem-cells
#19
Mahmoud Hashemi Tabar, Mohammad Reza Tabandeh, Eskandar Moghimipour, Dian Dayer, Ata A Ghadiri, Elham Allah Bakhshi, Mahmoud Orazizadeh, Mohammad Ali Ghafari
Pancreatic and duodenal homeobox 1 (Pdx1) and Sonic hedgehog (Shh) are the key regulators of beta-cell function. In vitro experiments have shown that there is significant cooperation between Pdx1 and Shh with regard to the production and maintenance of insulin-producing cells (IPCs). In this study, the combined effect of Pdx1 overexpression and Shh manipulation on the function of adipose tissue-derived IPCs was determined. A eukaryotic expression vector ( Pdx1- pCDNA3.1(+)) was constructed and transfected into a Chinese hamster ovary (CHO) cell line...
March 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29501580/the-systemic-bone-protective-effects-of-gushukang-granules-in-ovariectomized-mice-by-inhibiting-osteoclastogenesis-and-stimulating-osteoblastogenesis
#20
Qiang Wang, Yongjian Zhao, Nannan Sha, Yan Zhang, Chenguang Li, Hao Zhang, Dezhi Tang, Sheng Lu, Qi Shi, Yongjun Wang, Bing Shu, Dongfeng Zhao
Primary osteoporosis (POP), which is caused by unbalanced bone remodeling, leads to significant economic and societal burdens globally. Gushukang (GSK) granule serves as one commonly used prescription for POP in Traditional Chinese Medicine (TCM). The present study aimed to clarify the exact roles of GSK in bone remodeling with in vivo and in vitro assays. Here we showed that GSK prevented bone loss and the alternations of osteoporotic bone parameters as well as the decreased density of osteoclast in ovariectomized (OVX) mice...
March 2018: Journal of Pharmacological Sciences
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